Motif 32 (n=166)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RTX5 | TARS3 | S453 | ochoa | Threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase protein 3) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. {ECO:0000250|UniProtKB:Q8BLY2}. |
| E7EWF7 | None | S93 | ochoa | Uncharacterized protein | None |
| O00139 | KIF2A | S604 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O14686 | KMT2D | S4849 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15156 | ZBTB7B | S150 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15164 | TRIM24 | S209 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O43296 | ZNF264 | S177 | ochoa | Zinc finger protein 264 | May be involved in transcriptional regulation. |
| O60353 | FZD6 | S620 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O60499 | STX10 | S108 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O60502 | OGA | S511 | ochoa | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714, ECO:0000269|PubMed:28939839, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}. |
| O94806 | PRKD3 | S364 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O95139 | NDUFB6 | S55 | psp | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95259 | KCNH1 | S899 | ochoa | Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25420144, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:25915598, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:30149017, ECO:0000269|PubMed:9738473}. |
| O95490 | ADGRL2 | S1365 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95835 | LATS1 | S635 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P08237 | PFKM | S74 | psp | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P10644 | PRKAR1A | S83 | ochoa|psp | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}. |
| P12882 | MYH1 | T684 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S680 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | T683 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15408 | FOSL2 | S200 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P17661 | DES | S432 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P23497 | SP100 | S274 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P23511 | NFYA | S326 | ochoa|psp | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}. |
| P25490 | YY1 | S247 | ochoa|psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P26358 | DNMT1 | Y969 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P28324 | ELK4 | S180 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P31321 | PRKAR1B | S83 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
| P36507 | MAP2K2 | S23 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P41161 | ETV5 | S94 | ochoa | ETS translocation variant 5 (Ets-related protein ERM) | Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}. |
| P42166 | TMPO | S424 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42330 | AKR1C3 | S129 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P42702 | LIFR | S927 | ochoa | Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. |
| P43364 | MAGEA11 | S181 | psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P46087 | NOP2 | S67 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46100 | ATRX | S1527 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46527 | CDKN1B | S178 | ochoa|psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
| P46939 | UTRN | S295 | ochoa|psp | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P47736 | RAP1GAP | S515 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49321 | NASP | S726 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49795 | RGS19 | S151 | psp | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| P49902 | NT5C2 | S502 | ochoa|psp | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P51398 | DAP3 | S220 | psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P51398 | DAP3 | S280 | ochoa|psp | Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) | As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}. |
| P55347 | PKNOX1 | S41 | ochoa | Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) | Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}. |
| P57679 | EVC | S81 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P78559 | MAP1A | S1797 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q02040 | AKAP17A | S537 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q02952 | AKAP12 | T608 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q08J23 | NSUN2 | S743 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q10587 | TEF | S170 | ochoa | Thyrotroph embryonic factor | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. |
| Q12888 | TP53BP1 | S1678 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12931 | TRAP1 | S568 | ochoa|psp | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13610 | PWP1 | S57 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q13615 | MTMR3 | S913 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q14151 | SAFB2 | S343 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14162 | SCARF1 | S611 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14203 | DCTN1 | S1180 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14324 | MYBPC2 | S44 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14566 | MCM6 | S413 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14699 | RFTN1 | S521 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14980 | NUMA1 | S169 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15149 | PLEC | S149 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15262 | PTPRK | S835 | ochoa | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}. |
| Q15424 | SAFB | S344 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15562 | TEAD2 | S260 | ochoa | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q15652 | JMJD1C | S601 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15652 | JMJD1C | S2007 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16799 | RTN1 | S487 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2M2Z5 | KIZ | S179 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q2NKX8 | ERCC6L | S399 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2V2M9 | FHOD3 | S763 | ochoa | FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) | Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}. |
| Q3KR37 | GRAMD1B | S581 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3L8U1 | CHD9 | S2079 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q3T8J9 | GON4L | S2107 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q3V6T2 | CCDC88A | S1837 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q495A1 | TIGIT | S190 | ochoa | T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) | Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells (PubMed:19011627). Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116). Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity (PubMed:32503945). {ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:23154388, ECO:0000269|PubMed:24817116, ECO:0000269|PubMed:32503945}. |
| Q4ADV7 | RIC1 | S1371 | ochoa | Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) | The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}. |
| Q5HYC2 | BRD10 | S594 | ochoa | Uncharacterized bromodomain-containing protein 10 | None |
| Q5JPB2 | ZNF831 | S306 | ochoa | Zinc finger protein 831 | None |
| Q5JVL4 | EFHC1 | S524 | ochoa | EF-hand domain-containing protein 1 (Myoclonin-1) | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Microtubule-associated protein which regulates cell division and neuronal migration during cortical development (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581, PubMed:19734894, PubMed:22926142, PubMed:28370826). {ECO:0000269|PubMed:15258581, ECO:0000269|PubMed:19734894, ECO:0000269|PubMed:22926142, ECO:0000269|PubMed:28370826, ECO:0000269|PubMed:36191189}. |
| Q5T481 | RBM20 | S1120 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5TAX3 | TUT4 | S49 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5VTB9 | RNF220 | S282 | ochoa | E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}. |
| Q5VV42 | CDKAL1 | S53 | ochoa | Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}. |
| Q5VZK9 | CARMIL1 | S1101 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63HK3 | ZKSCAN2 | S600 | ochoa | Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) | May be involved in transcriptional regulation. |
| Q6UXF1 | TMEM108 | S543 | ochoa | Transmembrane protein 108 (Retrolinkin) | Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. {ECO:0000250|UniProtKB:Q8BHE4}. |
| Q765P7 | MTSS2 | S441 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q765P7 | MTSS2 | S624 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q76FK4 | NOL8 | S617 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7Z2K8 | GPRIN1 | S436 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z6E9 | RBBP6 | S861 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6Z7 | HUWE1 | S2918 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86T82 | USP37 | S462 | ochoa | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:26299517, ECO:0000269|PubMed:27296872, ECO:0000269|PubMed:31911859, ECO:0000269|PubMed:34509474, ECO:0000269|PubMed:34606619}. |
| Q86X29 | LSR | Y616 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YC2 | PALB2 | S387 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IXT5 | RBM12B | S254 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IY92 | SLX4 | S884 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IY92 | SLX4 | S1185 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8ND24 | RNF214 | S154 | ochoa | RING finger protein 214 | None |
| Q8NDI1 | EHBP1 | S295 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFW9 | MYRIP | S543 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TBA6 | GOLGA5 | S203 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8WVV4 | POF1B | S98 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WYL5 | SSH1 | S778 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92585 | MAML1 | S45 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92797 | SYMPK | S1243 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92844 | TANK | S117 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92934 | BAD | S91 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q96CS3 | FAF2 | S355 | ochoa | FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8) | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly (PubMed:34739333). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:34739333}. |
| Q96EV2 | RBM33 | S765 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96G42 | KLHDC7B | S164 | ochoa | Kelch domain-containing protein 7B | None |
| Q96HI0 | SENP5 | S176 | ochoa | Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5) | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. |
| Q96N64 | PWWP2A | S525 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96NJ6 | ZFP3 | S63 | ochoa | Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752) | May be involved in transcriptional regulation. |
| Q96RT1 | ERBIN | S857 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96SB4 | SRPK1 | S311 | ochoa | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q96T23 | RSF1 | S473 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T23 | RSF1 | S629 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99698 | LYST | S2217 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BW72 | HIGD2A | S25 | ochoa | HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b) | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269|PubMed:22342701}. |
| Q9BXK5 | BCL2L13 | S426 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BXL5 | HEMGN | S381 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BY89 | KIAA1671 | S366 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYW2 | SETD2 | S1084 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0C4 | SEMA4C | S717 | ochoa | Semaphorin-4C | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}. |
| Q9C0C9 | UBE2O | S431 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0C9 | UBE2O | S896 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9GZR7 | DDX24 | S287 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H0B6 | KLC2 | S151 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H0X9 | OSBPL5 | S88 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H2J7 | SLC6A15 | S687 | ochoa | Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3) | Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}. |
| Q9H3Q1 | CDC42EP4 | S322 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H694 | BICC1 | S612 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H6X5 | C19orf44 | S185 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9H7M9 | VSIR | S248 | ochoa | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}. |
| Q9HCE3 | ZNF532 | S1256 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCE9 | ANO8 | S641 | ochoa | Anoctamin-8 (Transmembrane protein 16H) | Does not exhibit calcium-activated chloride channel (CaCC) activity. |
| Q9HCM1 | RESF1 | S1208 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NQC3 | RTN4 | S991 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NS91 | RAD18 | S164 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NTI5 | PDS5B | S1283 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NUA8 | ZBTB40 | S621 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NUL3 | STAU2 | S188 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NVI1 | FANCI | S1120 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NVV0 | TMEM38B | S262 | ochoa | Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B) | Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Activated by increased cytosolic Ca(2+) levels (By similarity). {ECO:0000250|UniProtKB:Q6GN30}. |
| Q9NX40 | OCIAD1 | S191 | ochoa | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}. |
| Q9NX57 | RAB20 | S132 | ochoa | Ras-related protein Rab-20 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB20 plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:21255211}. |
| Q9NZT2 | OGFR | S378 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9UJU6 | DBNL | S232 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q9UK97 | FBXO9 | S33 | ochoa | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:23263282, PubMed:34480022). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:34480022}. |
| Q9UKL3 | CASP8AP2 | S928 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX2 | MYH2 | T686 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULI3 | HEG1 | S1293 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9UPN6 | SCAF8 | S617 | ochoa | SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| Q9UPZ3 | HPS5 | S602 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9UQB8 | BAIAP2 | S311 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2K6 | USP20 | S112 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y3M8 | STARD13 | S416 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y3R0 | GRIP1 | S996 | ochoa | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| Q9Y4B5 | MTCL1 | S1278 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y520 | PRRC2C | S2143 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y623 | MYH4 | T684 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6K1 | DNMT3A | S243 | ochoa | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
| Q15154 | PCM1 | S861 | Sugiyama | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:34782749}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.021988 | 1.658 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.021988 | 1.658 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.021988 | 1.658 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.021988 | 1.658 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.021988 | 1.658 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.043495 | 1.362 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.043495 | 1.362 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.043495 | 1.362 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.043495 | 1.362 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.043495 | 1.362 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.043495 | 1.362 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.043495 | 1.362 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.043495 | 1.362 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.043495 | 1.362 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.043495 | 1.362 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.043495 | 1.362 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.054072 | 1.267 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.054072 | 1.267 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 0.064532 | 1.190 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.085108 | 1.070 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.085108 | 1.070 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.095227 | 1.021 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.105235 | 0.978 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.115132 | 0.939 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.115132 | 0.939 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.124921 | 0.903 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.124921 | 0.903 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.134602 | 0.871 |
| R-HSA-390522 | Striated Muscle Contraction | 0.010414 | 1.982 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.153645 | 0.813 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.163010 | 0.788 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.163010 | 0.788 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.172272 | 0.764 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.190491 | 0.720 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.208311 | 0.681 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.225741 | 0.646 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.234313 | 0.630 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.242790 | 0.615 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.242790 | 0.615 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.242790 | 0.615 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.242790 | 0.615 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.291727 | 0.535 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.094690 | 1.024 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.187175 | 0.728 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.187175 | 0.728 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.195179 | 0.710 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.199198 | 0.701 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.227568 | 0.643 |
| R-HSA-380287 | Centrosome maturation | 0.235731 | 0.628 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.387233 | 0.412 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.280800 | 0.552 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.280800 | 0.552 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.407387 | 0.390 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.330097 | 0.481 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.251174 | 0.600 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.330097 | 0.481 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.301258 | 0.521 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.172272 | 0.764 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.337519 | 0.472 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.153645 | 0.813 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.208311 | 0.681 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.163010 | 0.788 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.187175 | 0.728 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.073708 | 1.132 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.070566 | 1.151 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.118118 | 0.928 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.387233 | 0.412 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.276702 | 0.558 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.190786 | 0.719 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.153645 | 0.813 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.067469 | 1.171 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.139874 | 0.854 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.139874 | 0.854 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.252102 | 0.598 |
| R-HSA-5334118 | DNA methylation | 0.058467 | 1.233 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.349868 | 0.456 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.053096 | 1.275 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.357870 | 0.446 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.115132 | 0.939 |
| R-HSA-163615 | PKA activation | 0.027506 | 1.561 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.027506 | 1.561 |
| R-HSA-176974 | Unwinding of DNA | 0.124921 | 0.903 |
| R-HSA-429947 | Deadenylation of mRNA | 0.044511 | 1.352 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.153645 | 0.813 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.163010 | 0.788 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.172272 | 0.764 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.083396 | 1.079 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.217075 | 0.663 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.267665 | 0.572 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.283795 | 0.547 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.203226 | 0.692 |
| R-HSA-68877 | Mitotic Prometaphase | 0.032118 | 1.493 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.387233 | 0.412 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.366398 | 0.436 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.172272 | 0.764 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.225741 | 0.646 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.366398 | 0.436 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.330097 | 0.481 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.002860 | 2.544 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.115132 | 0.939 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.125440 | 0.902 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.124921 | 0.903 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.329609 | 0.482 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.337519 | 0.472 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.085108 | 1.070 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.015690 | 1.804 |
| R-HSA-8964046 | VLDL clearance | 0.105235 | 0.978 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.181432 | 0.741 |
| R-HSA-9710421 | Defective pyroptosis | 0.110910 | 0.955 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.283795 | 0.547 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.283795 | 0.547 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.330097 | 0.481 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.352119 | 0.453 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.272602 | 0.564 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.400743 | 0.397 |
| R-HSA-69242 | S Phase | 0.281304 | 0.551 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.011832 | 1.927 |
| R-HSA-170968 | Frs2-mediated activation | 0.172272 | 0.764 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.283795 | 0.547 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.172272 | 0.764 |
| R-HSA-2028269 | Signaling by Hippo | 0.217075 | 0.663 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.103824 | 0.984 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.166078 | 0.780 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.004660 | 2.332 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.034402 | 1.463 |
| R-HSA-983189 | Kinesins | 0.040937 | 1.388 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.225741 | 0.646 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.330097 | 0.481 |
| R-HSA-5693538 | Homology Directed Repair | 0.182445 | 0.739 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.163010 | 0.788 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.199451 | 0.700 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.267665 | 0.572 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.366398 | 0.436 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.352119 | 0.453 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.322592 | 0.491 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.296357 | 0.528 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.013999 | 1.854 |
| R-HSA-5635838 | Activation of SMO | 0.199451 | 0.700 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.084262 | 1.074 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.352119 | 0.453 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.025146 | 1.600 |
| R-HSA-68886 | M Phase | 0.163891 | 0.785 |
| R-HSA-169893 | Prolonged ERK activation events | 0.199451 | 0.700 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.144190 | 0.841 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.008106 | 2.091 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.199451 | 0.700 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.225741 | 0.646 |
| R-HSA-9634597 | GPER1 signaling | 0.129142 | 0.889 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.171318 | 0.766 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.359298 | 0.445 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.394026 | 0.404 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.389500 | 0.409 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.011084 | 1.955 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.208101 | 0.682 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.011084 | 1.955 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.190491 | 0.720 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.100330 | 0.999 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.183190 | 0.737 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.117640 | 0.929 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.071892 | 1.143 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.283795 | 0.547 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.017353 | 1.761 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.067736 | 1.169 |
| R-HSA-1640170 | Cell Cycle | 0.114489 | 0.941 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.337804 | 0.471 |
| R-HSA-611105 | Respiratory electron transport | 0.374872 | 0.426 |
| R-HSA-180024 | DARPP-32 events | 0.058467 | 1.233 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.073708 | 1.132 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.208311 | 0.681 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.225741 | 0.646 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.118118 | 0.928 |
| R-HSA-9755088 | Ribavirin ADME | 0.259465 | 0.586 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.275775 | 0.559 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.307331 | 0.512 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.006359 | 2.197 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.198740 | 0.702 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.217075 | 0.663 |
| R-HSA-392517 | Rap1 signalling | 0.234313 | 0.630 |
| R-HSA-2161541 | Abacavir metabolism | 0.251174 | 0.600 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.259465 | 0.586 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.299572 | 0.523 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.315004 | 0.502 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.330097 | 0.481 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.118118 | 0.928 |
| R-HSA-69190 | DNA strand elongation | 0.344859 | 0.462 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.291727 | 0.535 |
| R-HSA-187687 | Signalling to ERKs | 0.373420 | 0.428 |
| R-HSA-68882 | Mitotic Anaphase | 0.268476 | 0.571 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.276702 | 0.558 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.270920 | 0.567 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.199451 | 0.700 |
| R-HSA-73894 | DNA Repair | 0.249257 | 0.603 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.041891 | 1.378 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.208311 | 0.681 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.330097 | 0.481 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.407387 | 0.390 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.199198 | 0.701 |
| R-HSA-2161522 | Abacavir ADME | 0.299572 | 0.523 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.400743 | 0.397 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.165310 | 0.782 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.020785 | 1.682 |
| R-HSA-445144 | Signal transduction by L1 | 0.242790 | 0.615 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.366398 | 0.436 |
| R-HSA-381042 | PERK regulates gene expression | 0.373420 | 0.428 |
| R-HSA-111933 | Calmodulin induced events | 0.083396 | 1.079 |
| R-HSA-111997 | CaM pathway | 0.083396 | 1.079 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.107351 | 0.969 |
| R-HSA-5673000 | RAF activation | 0.366398 | 0.436 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.179219 | 0.747 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.345855 | 0.461 |
| R-HSA-1483255 | PI Metabolism | 0.357870 | 0.446 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.049927 | 1.302 |
| R-HSA-111996 | Ca-dependent events | 0.107351 | 0.969 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.234313 | 0.630 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.118118 | 0.928 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.267665 | 0.572 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.163478 | 0.787 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.373420 | 0.428 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.387233 | 0.412 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.373420 | 0.428 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.256200 | 0.591 |
| R-HSA-109581 | Apoptosis | 0.323557 | 0.490 |
| R-HSA-112043 | PLC beta mediated events | 0.179219 | 0.747 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.344859 | 0.462 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.034402 | 1.463 |
| R-HSA-264876 | Insulin processing | 0.307331 | 0.512 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.366398 | 0.436 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.400743 | 0.397 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.067469 | 1.171 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.288992 | 0.539 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.217075 | 0.663 |
| R-HSA-8964038 | LDL clearance | 0.267665 | 0.572 |
| R-HSA-112040 | G-protein mediated events | 0.203226 | 0.692 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.248494 | 0.605 |
| R-HSA-201556 | Signaling by ALK | 0.400743 | 0.397 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.124896 | 0.903 |
| R-HSA-9607240 | FLT3 Signaling | 0.100330 | 0.999 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.036835 | 1.434 |
| R-HSA-182971 | EGFR downregulation | 0.337519 | 0.472 |
| R-HSA-8853659 | RET signaling | 0.380365 | 0.420 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.251454 | 0.600 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.365836 | 0.437 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.067736 | 1.169 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.359298 | 0.445 |
| R-HSA-75153 | Apoptotic execution phase | 0.121765 | 0.914 |
| R-HSA-111885 | Opioid Signalling | 0.365836 | 0.437 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.349868 | 0.456 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.313490 | 0.504 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.357870 | 0.446 |
| R-HSA-1280218 | Adaptive Immune System | 0.407508 | 0.390 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.293084 | 0.533 |
| R-HSA-422356 | Regulation of insulin secretion | 0.341833 | 0.466 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.305340 | 0.515 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.284897 | 0.545 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.309417 | 0.509 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.408920 | 0.388 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.413957 | 0.383 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.420455 | 0.376 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.420455 | 0.376 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.420455 | 0.376 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.420455 | 0.376 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.420455 | 0.376 |
| R-HSA-9658195 | Leishmania infection | 0.430494 | 0.366 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.430494 | 0.366 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.431823 | 0.365 |
| R-HSA-68875 | Mitotic Prophase | 0.439353 | 0.357 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.439521 | 0.357 |
| R-HSA-69236 | G1 Phase | 0.439521 | 0.357 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.439521 | 0.357 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.439521 | 0.357 |
| R-HSA-73886 | Chromosome Maintenance | 0.443098 | 0.354 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.445737 | 0.351 |
| R-HSA-774815 | Nucleosome assembly | 0.445737 | 0.351 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.445737 | 0.351 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.451885 | 0.345 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.451885 | 0.345 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.451885 | 0.345 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.451885 | 0.345 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.451885 | 0.345 |
| R-HSA-9675135 | Diseases of DNA repair | 0.451885 | 0.345 |
| R-HSA-5357801 | Programmed Cell Death | 0.457369 | 0.340 |
| R-HSA-112316 | Neuronal System | 0.461182 | 0.336 |
| R-HSA-69206 | G1/S Transition | 0.461613 | 0.336 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.463977 | 0.334 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.465273 | 0.332 |
| R-HSA-69481 | G2/M Checkpoints | 0.468918 | 0.329 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.469923 | 0.328 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.469923 | 0.328 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.469923 | 0.328 |
| R-HSA-73893 | DNA Damage Bypass | 0.469923 | 0.328 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.475803 | 0.323 |
| R-HSA-397014 | Muscle contraction | 0.477319 | 0.321 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.477319 | 0.321 |
| R-HSA-9864848 | Complex IV assembly | 0.481619 | 0.317 |
| R-HSA-212436 | Generic Transcription Pathway | 0.484970 | 0.314 |
| R-HSA-72187 | mRNA 3'-end processing | 0.487371 | 0.312 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.487371 | 0.312 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.487371 | 0.312 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.487371 | 0.312 |
| R-HSA-72649 | Translation initiation complex formation | 0.498684 | 0.302 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.504247 | 0.297 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.504247 | 0.297 |
| R-HSA-418597 | G alpha (z) signalling events | 0.504247 | 0.297 |
| R-HSA-163685 | Integration of energy metabolism | 0.508022 | 0.294 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.509749 | 0.293 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.509749 | 0.293 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.509749 | 0.293 |
| R-HSA-177929 | Signaling by EGFR | 0.509749 | 0.293 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.515190 | 0.288 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.516167 | 0.287 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.520571 | 0.284 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.520571 | 0.284 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.521774 | 0.283 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.521774 | 0.283 |
| R-HSA-9664407 | Parasite infection | 0.521774 | 0.283 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.525172 | 0.280 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.525893 | 0.279 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.525893 | 0.279 |
| R-HSA-186712 | Regulation of beta-cell development | 0.525893 | 0.279 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.525893 | 0.279 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.530910 | 0.275 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.531156 | 0.275 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.531156 | 0.275 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.531156 | 0.275 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.531156 | 0.275 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.531156 | 0.275 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.531156 | 0.275 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.531156 | 0.275 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.531156 | 0.275 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.531156 | 0.275 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.531156 | 0.275 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.536360 | 0.271 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.536360 | 0.271 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.537668 | 0.269 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.541508 | 0.266 |
| R-HSA-9707616 | Heme signaling | 0.541508 | 0.266 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.541815 | 0.266 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.545216 | 0.263 |
| R-HSA-6799198 | Complex I biogenesis | 0.546598 | 0.262 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.546598 | 0.262 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.546598 | 0.262 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.546598 | 0.262 |
| R-HSA-8848021 | Signaling by PTK6 | 0.546598 | 0.262 |
| R-HSA-9758941 | Gastrulation | 0.555017 | 0.256 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.561535 | 0.251 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.566404 | 0.247 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.566404 | 0.247 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.566404 | 0.247 |
| R-HSA-73887 | Death Receptor Signaling | 0.571019 | 0.243 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.571220 | 0.243 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.571220 | 0.243 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.573462 | 0.241 |
| R-HSA-1989781 | PPARA activates gene expression | 0.574169 | 0.241 |
| R-HSA-4839726 | Chromatin organization | 0.576484 | 0.239 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.580419 | 0.236 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.580692 | 0.236 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.580692 | 0.236 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.585350 | 0.233 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.585350 | 0.233 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.585350 | 0.233 |
| R-HSA-877300 | Interferon gamma signaling | 0.586603 | 0.232 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.589956 | 0.229 |
| R-HSA-74259 | Purine catabolism | 0.589956 | 0.229 |
| R-HSA-5688426 | Deubiquitination | 0.591434 | 0.228 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.594512 | 0.226 |
| R-HSA-4086398 | Ca2+ pathway | 0.594512 | 0.226 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.594512 | 0.226 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.599017 | 0.223 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.599017 | 0.223 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.599017 | 0.223 |
| R-HSA-597592 | Post-translational protein modification | 0.601429 | 0.221 |
| R-HSA-8852135 | Protein ubiquitination | 0.603472 | 0.219 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.603472 | 0.219 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.603472 | 0.219 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.607878 | 0.216 |
| R-HSA-5689603 | UCH proteinases | 0.607878 | 0.216 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.612236 | 0.213 |
| R-HSA-4086400 | PCP/CE pathway | 0.616545 | 0.210 |
| R-HSA-199991 | Membrane Trafficking | 0.617350 | 0.209 |
| R-HSA-72306 | tRNA processing | 0.622290 | 0.206 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.625021 | 0.204 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.625021 | 0.204 |
| R-HSA-418555 | G alpha (s) signalling events | 0.625155 | 0.204 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.629189 | 0.201 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.629189 | 0.201 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.629189 | 0.201 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.630506 | 0.200 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.630834 | 0.200 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.630834 | 0.200 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.630834 | 0.200 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.633311 | 0.198 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.633311 | 0.198 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.633649 | 0.198 |
| R-HSA-74160 | Gene expression (Transcription) | 0.634167 | 0.198 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.637387 | 0.196 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.641418 | 0.193 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.649348 | 0.188 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.658233 | 0.182 |
| R-HSA-69275 | G2/M Transition | 0.666131 | 0.176 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.668416 | 0.175 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.671315 | 0.173 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.672104 | 0.173 |
| R-HSA-5617833 | Cilium Assembly | 0.676434 | 0.170 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.679359 | 0.168 |
| R-HSA-1483257 | Phospholipid metabolism | 0.682175 | 0.166 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.682926 | 0.166 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.686453 | 0.163 |
| R-HSA-1474290 | Collagen formation | 0.686453 | 0.163 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.689942 | 0.161 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.693392 | 0.159 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.696804 | 0.157 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.696804 | 0.157 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.696804 | 0.157 |
| R-HSA-1296071 | Potassium Channels | 0.696804 | 0.157 |
| R-HSA-157579 | Telomere Maintenance | 0.700178 | 0.155 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.703514 | 0.153 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.703514 | 0.153 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.706814 | 0.151 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.707224 | 0.150 |
| R-HSA-70171 | Glycolysis | 0.710078 | 0.149 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.713305 | 0.147 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.719652 | 0.143 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.728912 | 0.137 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.728912 | 0.137 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.730856 | 0.136 |
| R-HSA-69239 | Synthesis of DNA | 0.734916 | 0.134 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.736289 | 0.133 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.737868 | 0.132 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.737868 | 0.132 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.737868 | 0.132 |
| R-HSA-8957322 | Metabolism of steroids | 0.738080 | 0.132 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.740788 | 0.130 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.740788 | 0.130 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.743675 | 0.129 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.743675 | 0.129 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.743675 | 0.129 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.749353 | 0.125 |
| R-HSA-8951664 | Neddylation | 0.749817 | 0.125 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.752146 | 0.124 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.757638 | 0.121 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.763008 | 0.117 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.765649 | 0.116 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.765649 | 0.116 |
| R-HSA-373760 | L1CAM interactions | 0.765649 | 0.116 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.767090 | 0.115 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.768261 | 0.114 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.768261 | 0.114 |
| R-HSA-70326 | Glucose metabolism | 0.768261 | 0.114 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.768261 | 0.114 |
| R-HSA-8939211 | ESR-mediated signaling | 0.780863 | 0.107 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.790501 | 0.102 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.790501 | 0.102 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.790501 | 0.102 |
| R-HSA-194138 | Signaling by VEGF | 0.790501 | 0.102 |
| R-HSA-109582 | Hemostasis | 0.795456 | 0.099 |
| R-HSA-162582 | Signal Transduction | 0.797344 | 0.098 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.797432 | 0.098 |
| R-HSA-8956319 | Nucleotide catabolism | 0.799691 | 0.097 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.800717 | 0.097 |
| R-HSA-9843745 | Adipogenesis | 0.806320 | 0.093 |
| R-HSA-9909396 | Circadian clock | 0.808481 | 0.092 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.818930 | 0.087 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.818930 | 0.087 |
| R-HSA-5368287 | Mitochondrial translation | 0.822949 | 0.085 |
| R-HSA-1632852 | Macroautophagy | 0.828812 | 0.082 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.831559 | 0.080 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.836736 | 0.077 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.841752 | 0.075 |
| R-HSA-2187338 | Visual phototransduction | 0.841752 | 0.075 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.843519 | 0.074 |
| R-HSA-166520 | Signaling by NTRKs | 0.843519 | 0.074 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.846996 | 0.072 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.846996 | 0.072 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.848705 | 0.071 |
| R-HSA-2142753 | Arachidonate metabolism | 0.850395 | 0.070 |
| R-HSA-69306 | DNA Replication | 0.852066 | 0.070 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.853719 | 0.069 |
| R-HSA-9612973 | Autophagy | 0.856970 | 0.067 |
| R-HSA-418594 | G alpha (i) signalling events | 0.856981 | 0.067 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.866867 | 0.062 |
| R-HSA-195721 | Signaling by WNT | 0.870343 | 0.060 |
| R-HSA-392499 | Metabolism of proteins | 0.877103 | 0.057 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.881854 | 0.055 |
| R-HSA-2559583 | Cellular Senescence | 0.892025 | 0.050 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.901324 | 0.045 |
| R-HSA-983712 | Ion channel transport | 0.902429 | 0.045 |
| R-HSA-6798695 | Neutrophil degranulation | 0.902818 | 0.044 |
| R-HSA-1474244 | Extracellular matrix organization | 0.903449 | 0.044 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.904602 | 0.044 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.913801 | 0.039 |
| R-HSA-428157 | Sphingolipid metabolism | 0.914767 | 0.039 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.915722 | 0.038 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.916667 | 0.038 |
| R-HSA-8953854 | Metabolism of RNA | 0.918002 | 0.037 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.918017 | 0.037 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.926387 | 0.033 |
| R-HSA-9748784 | Drug ADME | 0.930424 | 0.031 |
| R-HSA-72312 | rRNA processing | 0.940594 | 0.027 |
| R-HSA-913531 | Interferon Signaling | 0.940645 | 0.027 |
| R-HSA-15869 | Metabolism of nucleotides | 0.943218 | 0.025 |
| R-HSA-157118 | Signaling by NOTCH | 0.945727 | 0.024 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.951052 | 0.022 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.954707 | 0.020 |
| R-HSA-168256 | Immune System | 0.958554 | 0.018 |
| R-HSA-416476 | G alpha (q) signalling events | 0.958626 | 0.018 |
| R-HSA-72766 | Translation | 0.961519 | 0.017 |
| R-HSA-446728 | Cell junction organization | 0.964690 | 0.016 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.965088 | 0.015 |
| R-HSA-9675108 | Nervous system development | 0.965389 | 0.015 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.968827 | 0.014 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.971205 | 0.013 |
| R-HSA-2262752 | Cellular responses to stress | 0.976534 | 0.010 |
| R-HSA-1500931 | Cell-Cell communication | 0.977051 | 0.010 |
| R-HSA-1266738 | Developmental Biology | 0.977630 | 0.010 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.983865 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.986703 | 0.006 |
| R-HSA-422475 | Axon guidance | 0.987564 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 0.988254 | 0.005 |
| R-HSA-9679506 | SARS-CoV Infections | 0.988742 | 0.005 |
| R-HSA-1643685 | Disease | 0.989164 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.989289 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.990225 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.990976 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 0.991949 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993217 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.993827 | 0.003 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.994514 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995350 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.997962 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998332 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999005 | 0.000 |
| R-HSA-449147 | Signaling by Interleukins | 0.999344 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999701 | 0.000 |
| R-HSA-9824446 | Viral Infection Pathways | 0.999974 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.820 | 0.650 | 1 | 0.741 |
P38G |
0.815 | 0.710 | 1 | 0.866 |
CDK1 |
0.811 | 0.667 | 1 | 0.802 |
CDK3 |
0.811 | 0.603 | 1 | 0.848 |
JNK2 |
0.809 | 0.710 | 1 | 0.820 |
CDK19 |
0.807 | 0.645 | 1 | 0.804 |
CDK17 |
0.806 | 0.671 | 1 | 0.855 |
CDK18 |
0.805 | 0.650 | 1 | 0.820 |
CDK8 |
0.804 | 0.650 | 1 | 0.766 |
HIPK2 |
0.801 | 0.582 | 1 | 0.799 |
P38D |
0.800 | 0.676 | 1 | 0.856 |
ERK1 |
0.799 | 0.663 | 1 | 0.805 |
CDK16 |
0.799 | 0.641 | 1 | 0.839 |
CDK5 |
0.798 | 0.638 | 1 | 0.741 |
JNK3 |
0.798 | 0.696 | 1 | 0.789 |
CLK3 |
0.797 | 0.434 | 1 | 0.457 |
P38B |
0.796 | 0.657 | 1 | 0.790 |
CDK13 |
0.795 | 0.646 | 1 | 0.793 |
CDK12 |
0.793 | 0.643 | 1 | 0.816 |
CDK7 |
0.792 | 0.625 | 1 | 0.770 |
P38A |
0.787 | 0.643 | 1 | 0.714 |
DYRK2 |
0.784 | 0.554 | 1 | 0.710 |
ERK2 |
0.783 | 0.654 | 1 | 0.751 |
CDK10 |
0.783 | 0.580 | 1 | 0.795 |
DYRK4 |
0.783 | 0.574 | 1 | 0.811 |
JNK1 |
0.782 | 0.632 | 1 | 0.821 |
CDK9 |
0.781 | 0.613 | 1 | 0.785 |
SRPK1 |
0.780 | 0.254 | -3 | 0.344 |
CDK14 |
0.779 | 0.607 | 1 | 0.777 |
HIPK1 |
0.778 | 0.512 | 1 | 0.687 |
CLK2 |
0.778 | 0.318 | -3 | 0.365 |
CDK6 |
0.777 | 0.611 | 1 | 0.795 |
CDK4 |
0.776 | 0.625 | 1 | 0.822 |
DYRK1B |
0.776 | 0.542 | 1 | 0.769 |
CDK2 |
0.775 | 0.503 | 1 | 0.672 |
SRPK2 |
0.773 | 0.205 | -3 | 0.310 |
NLK |
0.772 | 0.542 | 1 | 0.492 |
CLK1 |
0.772 | 0.307 | -3 | 0.346 |
HIPK4 |
0.770 | 0.333 | 1 | 0.483 |
DYRK1A |
0.766 | 0.435 | 1 | 0.668 |
CLK4 |
0.765 | 0.275 | -3 | 0.359 |
HIPK3 |
0.764 | 0.487 | 1 | 0.660 |
ERK5 |
0.762 | 0.296 | 1 | 0.414 |
COT |
0.762 | 0.049 | 2 | 0.862 |
SRPK3 |
0.761 | 0.182 | -3 | 0.337 |
MTOR |
0.760 | 0.185 | 1 | 0.284 |
DYRK3 |
0.757 | 0.385 | 1 | 0.649 |
MAK |
0.754 | 0.353 | -2 | 0.654 |
BMPR1B |
0.752 | 0.126 | 1 | 0.097 |
PRP4 |
0.751 | 0.327 | -3 | 0.376 |
ICK |
0.751 | 0.231 | -3 | 0.385 |
CDKL5 |
0.749 | 0.088 | -3 | 0.360 |
CDKL1 |
0.748 | 0.071 | -3 | 0.374 |
MOS |
0.746 | 0.017 | 1 | 0.154 |
CDC7 |
0.746 | -0.058 | 1 | 0.118 |
TGFBR2 |
0.745 | 0.060 | -2 | 0.909 |
GCN2 |
0.745 | -0.035 | 2 | 0.786 |
DSTYK |
0.745 | -0.055 | 2 | 0.888 |
MOK |
0.743 | 0.325 | 1 | 0.576 |
TGFBR1 |
0.743 | 0.129 | -2 | 0.931 |
PRPK |
0.742 | -0.033 | -1 | 0.879 |
CHAK2 |
0.742 | 0.035 | -1 | 0.917 |
TBK1 |
0.742 | -0.091 | 1 | 0.081 |
BMPR2 |
0.741 | 0.019 | -2 | 0.882 |
NEK6 |
0.740 | -0.047 | -2 | 0.871 |
BMPR1A |
0.740 | 0.142 | 1 | 0.087 |
PIM3 |
0.740 | -0.062 | -3 | 0.408 |
ERK7 |
0.739 | 0.220 | 2 | 0.556 |
GRK7 |
0.738 | 0.056 | 1 | 0.134 |
ALK4 |
0.738 | 0.117 | -2 | 0.929 |
PIM1 |
0.737 | -0.017 | -3 | 0.372 |
IKKE |
0.737 | -0.114 | 1 | 0.082 |
NUAK2 |
0.736 | -0.031 | -3 | 0.399 |
ATR |
0.736 | -0.057 | 1 | 0.147 |
PRKD2 |
0.735 | -0.042 | -3 | 0.347 |
IKKB |
0.734 | -0.122 | -2 | 0.691 |
PRKD1 |
0.734 | -0.056 | -3 | 0.370 |
ALK2 |
0.734 | 0.111 | -2 | 0.923 |
CAMK1B |
0.733 | -0.077 | -3 | 0.410 |
ACVR2A |
0.733 | 0.084 | -2 | 0.902 |
RSK2 |
0.733 | -0.052 | -3 | 0.359 |
PDHK4 |
0.733 | -0.160 | 1 | 0.161 |
ACVR2B |
0.733 | 0.079 | -2 | 0.904 |
NEK7 |
0.733 | -0.133 | -3 | 0.399 |
MAPKAPK2 |
0.733 | -0.053 | -3 | 0.340 |
NDR2 |
0.733 | -0.071 | -3 | 0.399 |
PLK3 |
0.732 | 0.114 | 2 | 0.746 |
MST4 |
0.732 | -0.058 | 2 | 0.860 |
PKN3 |
0.732 | -0.084 | -3 | 0.384 |
ULK2 |
0.732 | -0.176 | 2 | 0.770 |
CAMK2G |
0.731 | -0.076 | 2 | 0.790 |
RAF1 |
0.731 | -0.180 | 1 | 0.097 |
IKKA |
0.731 | -0.032 | -2 | 0.704 |
NIK |
0.730 | -0.098 | -3 | 0.424 |
MLK1 |
0.730 | -0.085 | 2 | 0.806 |
GRK1 |
0.729 | -0.026 | -2 | 0.747 |
P90RSK |
0.729 | -0.057 | -3 | 0.362 |
ATM |
0.728 | -0.023 | 1 | 0.117 |
PKCD |
0.728 | -0.057 | 2 | 0.783 |
LATS2 |
0.727 | -0.065 | -5 | 0.723 |
MAPKAPK3 |
0.727 | -0.097 | -3 | 0.347 |
MLK3 |
0.727 | -0.025 | 2 | 0.741 |
PLK2 |
0.727 | 0.258 | -3 | 0.759 |
GRK5 |
0.726 | -0.116 | -3 | 0.430 |
RSK3 |
0.726 | -0.063 | -3 | 0.375 |
NDR1 |
0.726 | -0.099 | -3 | 0.392 |
WNK1 |
0.726 | -0.134 | -2 | 0.771 |
ULK1 |
0.725 | -0.153 | -3 | 0.385 |
PINK1 |
0.725 | 0.129 | 1 | 0.306 |
GRK6 |
0.725 | -0.070 | 1 | 0.100 |
PLK1 |
0.724 | -0.033 | -2 | 0.858 |
DNAPK |
0.724 | -0.040 | 1 | 0.142 |
PDHK1 |
0.724 | -0.205 | 1 | 0.137 |
FAM20C |
0.724 | 0.034 | 2 | 0.659 |
PKN2 |
0.724 | -0.116 | -3 | 0.378 |
HUNK |
0.724 | -0.147 | 2 | 0.780 |
MLK4 |
0.723 | -0.006 | 2 | 0.727 |
CAMLCK |
0.723 | -0.084 | -2 | 0.752 |
TLK2 |
0.722 | -0.003 | 1 | 0.087 |
NEK9 |
0.722 | -0.172 | 2 | 0.826 |
LATS1 |
0.722 | -0.024 | -3 | 0.406 |
P70S6KB |
0.722 | -0.068 | -3 | 0.366 |
SKMLCK |
0.722 | -0.114 | -2 | 0.756 |
CAMK2B |
0.722 | -0.052 | 2 | 0.777 |
PKR |
0.722 | -0.035 | 1 | 0.110 |
GRK4 |
0.721 | -0.072 | -2 | 0.820 |
AMPKA1 |
0.721 | -0.114 | -3 | 0.396 |
PRKD3 |
0.721 | -0.062 | -3 | 0.339 |
CAMK2D |
0.721 | -0.126 | -3 | 0.372 |
PHKG1 |
0.720 | -0.083 | -3 | 0.381 |
GSK3A |
0.720 | 0.155 | 4 | 0.453 |
MLK2 |
0.720 | -0.124 | 2 | 0.824 |
IRE1 |
0.720 | -0.098 | 1 | 0.090 |
DLK |
0.719 | -0.182 | 1 | 0.110 |
NUAK1 |
0.719 | -0.077 | -3 | 0.370 |
TTBK2 |
0.718 | -0.125 | 2 | 0.674 |
BCKDK |
0.718 | -0.156 | -1 | 0.808 |
DAPK2 |
0.718 | -0.126 | -3 | 0.404 |
MARK4 |
0.718 | -0.116 | 4 | 0.805 |
AURC |
0.718 | -0.042 | -2 | 0.532 |
CAMK2A |
0.718 | -0.055 | 2 | 0.783 |
AMPKA2 |
0.718 | -0.099 | -3 | 0.377 |
PKCB |
0.718 | -0.064 | 2 | 0.738 |
RIPK3 |
0.717 | -0.194 | 3 | 0.603 |
RSK4 |
0.717 | -0.054 | -3 | 0.351 |
GRK2 |
0.717 | -0.021 | -2 | 0.708 |
SMG1 |
0.717 | -0.064 | 1 | 0.132 |
IRE2 |
0.716 | -0.071 | 2 | 0.734 |
YSK4 |
0.716 | -0.122 | 1 | 0.084 |
TSSK1 |
0.716 | -0.092 | -3 | 0.409 |
ANKRD3 |
0.716 | -0.161 | 1 | 0.110 |
PERK |
0.716 | -0.029 | -2 | 0.879 |
CK1E |
0.715 | -0.046 | -3 | 0.300 |
VRK2 |
0.714 | -0.030 | 1 | 0.195 |
MNK2 |
0.714 | -0.077 | -2 | 0.673 |
TLK1 |
0.714 | -0.016 | -2 | 0.896 |
PKACB |
0.714 | -0.052 | -2 | 0.550 |
AKT2 |
0.714 | -0.044 | -3 | 0.314 |
PKACG |
0.714 | -0.099 | -2 | 0.617 |
PIM2 |
0.714 | -0.039 | -3 | 0.339 |
PKCA |
0.713 | -0.070 | 2 | 0.729 |
CHAK1 |
0.713 | -0.099 | 2 | 0.776 |
MASTL |
0.713 | -0.213 | -2 | 0.760 |
TSSK2 |
0.712 | -0.119 | -5 | 0.806 |
WNK3 |
0.712 | -0.248 | 1 | 0.093 |
DCAMKL1 |
0.712 | -0.073 | -3 | 0.375 |
PRKX |
0.712 | -0.036 | -3 | 0.318 |
CHK1 |
0.712 | -0.060 | -3 | 0.432 |
PKCG |
0.711 | -0.087 | 2 | 0.726 |
HRI |
0.711 | -0.086 | -2 | 0.877 |
CK1D |
0.710 | -0.035 | -3 | 0.251 |
MSK2 |
0.710 | -0.104 | -3 | 0.341 |
MEK1 |
0.710 | -0.129 | 2 | 0.814 |
MNK1 |
0.710 | -0.079 | -2 | 0.685 |
PKCZ |
0.710 | -0.091 | 2 | 0.775 |
NIM1 |
0.709 | -0.135 | 3 | 0.660 |
MPSK1 |
0.709 | -0.024 | 1 | 0.159 |
PAK1 |
0.709 | -0.103 | -2 | 0.659 |
MELK |
0.709 | -0.138 | -3 | 0.359 |
NEK2 |
0.709 | -0.173 | 2 | 0.805 |
RIPK1 |
0.709 | -0.245 | 1 | 0.083 |
CK2A2 |
0.709 | -0.012 | 1 | 0.087 |
TAO3 |
0.708 | -0.048 | 1 | 0.130 |
SGK3 |
0.708 | -0.083 | -3 | 0.341 |
PKCH |
0.708 | -0.100 | 2 | 0.711 |
CAMK4 |
0.708 | -0.171 | -3 | 0.380 |
PAK6 |
0.707 | -0.074 | -2 | 0.564 |
MEKK2 |
0.706 | -0.062 | 2 | 0.791 |
PAK3 |
0.706 | -0.131 | -2 | 0.658 |
CK1G1 |
0.706 | -0.074 | -3 | 0.290 |
GRK3 |
0.705 | -0.023 | -2 | 0.675 |
MAPKAPK5 |
0.705 | -0.129 | -3 | 0.312 |
MSK1 |
0.705 | -0.089 | -3 | 0.342 |
PLK4 |
0.705 | -0.109 | 2 | 0.588 |
MEKK1 |
0.705 | -0.119 | 1 | 0.104 |
SIK |
0.705 | -0.111 | -3 | 0.348 |
QSK |
0.704 | -0.109 | 4 | 0.777 |
MST3 |
0.704 | -0.087 | 2 | 0.837 |
ZAK |
0.704 | -0.123 | 1 | 0.091 |
BRSK1 |
0.704 | -0.114 | -3 | 0.370 |
NEK5 |
0.704 | -0.148 | 1 | 0.090 |
DCAMKL2 |
0.704 | -0.077 | -3 | 0.385 |
MEKK3 |
0.703 | -0.127 | 1 | 0.106 |
DRAK1 |
0.703 | -0.146 | 1 | 0.086 |
CAMK1G |
0.702 | -0.108 | -3 | 0.337 |
AURB |
0.702 | -0.076 | -2 | 0.529 |
QIK |
0.702 | -0.168 | -3 | 0.374 |
PKG2 |
0.702 | -0.088 | -2 | 0.542 |
PASK |
0.701 | -0.076 | -3 | 0.412 |
MEK5 |
0.701 | -0.172 | 2 | 0.813 |
CK1A2 |
0.701 | -0.061 | -3 | 0.254 |
MYLK4 |
0.700 | -0.111 | -2 | 0.652 |
BRAF |
0.700 | -0.116 | -4 | 0.835 |
GAK |
0.700 | -0.045 | 1 | 0.151 |
SBK |
0.700 | 0.028 | -3 | 0.252 |
PHKG2 |
0.699 | -0.114 | -3 | 0.360 |
BRSK2 |
0.699 | -0.146 | -3 | 0.365 |
AKT1 |
0.699 | -0.072 | -3 | 0.315 |
MARK3 |
0.699 | -0.101 | 4 | 0.727 |
PKCT |
0.698 | -0.103 | 2 | 0.725 |
TAO2 |
0.698 | -0.075 | 2 | 0.842 |
TNIK |
0.698 | -0.041 | 3 | 0.780 |
GCK |
0.698 | -0.088 | 1 | 0.115 |
CAMK1D |
0.697 | -0.089 | -3 | 0.321 |
GSK3B |
0.697 | 0.017 | 4 | 0.442 |
CHK2 |
0.697 | -0.071 | -3 | 0.285 |
CK2A1 |
0.696 | -0.035 | 1 | 0.081 |
IRAK4 |
0.696 | -0.160 | 1 | 0.070 |
MST2 |
0.696 | -0.064 | 1 | 0.097 |
EEF2K |
0.696 | -0.032 | 3 | 0.765 |
MARK2 |
0.696 | -0.112 | 4 | 0.695 |
PAK2 |
0.696 | -0.142 | -2 | 0.643 |
AURA |
0.696 | -0.076 | -2 | 0.512 |
PKACA |
0.695 | -0.072 | -2 | 0.495 |
WNK4 |
0.695 | -0.172 | -2 | 0.766 |
SGK1 |
0.695 | -0.040 | -3 | 0.277 |
HGK |
0.695 | -0.081 | 3 | 0.771 |
PKCI |
0.694 | -0.085 | 2 | 0.737 |
LKB1 |
0.694 | -0.113 | -3 | 0.379 |
PKCE |
0.694 | -0.058 | 2 | 0.714 |
NEK11 |
0.694 | -0.168 | 1 | 0.126 |
P70S6K |
0.693 | -0.101 | -3 | 0.309 |
NEK8 |
0.692 | -0.157 | 2 | 0.806 |
PKN1 |
0.692 | -0.091 | -3 | 0.313 |
AKT3 |
0.692 | -0.056 | -3 | 0.282 |
BUB1 |
0.691 | -0.026 | -5 | 0.792 |
MARK1 |
0.691 | -0.138 | 4 | 0.754 |
MINK |
0.690 | -0.113 | 1 | 0.085 |
HASPIN |
0.690 | 0.008 | -1 | 0.791 |
PDK1 |
0.690 | -0.115 | 1 | 0.135 |
SMMLCK |
0.690 | -0.121 | -3 | 0.370 |
KHS2 |
0.690 | -0.051 | 1 | 0.118 |
MAP3K15 |
0.689 | -0.130 | 1 | 0.104 |
LOK |
0.689 | -0.092 | -2 | 0.678 |
HPK1 |
0.689 | -0.110 | 1 | 0.117 |
SLK |
0.689 | -0.073 | -2 | 0.636 |
TTBK1 |
0.689 | -0.149 | 2 | 0.587 |
KHS1 |
0.688 | -0.084 | 1 | 0.105 |
MEKK6 |
0.688 | -0.141 | 1 | 0.108 |
MST1 |
0.688 | -0.103 | 1 | 0.086 |
PAK5 |
0.688 | -0.099 | -2 | 0.508 |
BIKE |
0.687 | -0.020 | 1 | 0.146 |
AAK1 |
0.687 | 0.011 | 1 | 0.159 |
LRRK2 |
0.687 | -0.076 | 2 | 0.831 |
NEK4 |
0.687 | -0.193 | 1 | 0.079 |
CAMKK1 |
0.687 | -0.215 | -2 | 0.688 |
CAMK1A |
0.687 | -0.082 | -3 | 0.295 |
TTK |
0.687 | 0.042 | -2 | 0.886 |
SNRK |
0.687 | -0.225 | 2 | 0.654 |
MRCKB |
0.686 | -0.070 | -3 | 0.327 |
SSTK |
0.685 | -0.122 | 4 | 0.775 |
PBK |
0.685 | -0.073 | 1 | 0.136 |
OSR1 |
0.684 | -0.023 | 2 | 0.792 |
NEK1 |
0.684 | -0.185 | 1 | 0.072 |
DAPK3 |
0.684 | -0.110 | -3 | 0.373 |
TAK1 |
0.683 | -0.187 | 1 | 0.084 |
ROCK2 |
0.682 | -0.077 | -3 | 0.360 |
CAMKK2 |
0.682 | -0.203 | -2 | 0.672 |
PAK4 |
0.681 | -0.093 | -2 | 0.520 |
VRK1 |
0.681 | -0.160 | 2 | 0.809 |
MRCKA |
0.681 | -0.085 | -3 | 0.340 |
YSK1 |
0.680 | -0.129 | 2 | 0.808 |
DMPK1 |
0.679 | -0.050 | -3 | 0.347 |
IRAK1 |
0.678 | -0.241 | -1 | 0.806 |
DAPK1 |
0.676 | -0.114 | -3 | 0.361 |
CRIK |
0.676 | -0.058 | -3 | 0.310 |
NEK3 |
0.675 | -0.146 | 1 | 0.103 |
MEK2 |
0.675 | -0.175 | 2 | 0.787 |
STK33 |
0.675 | -0.146 | 2 | 0.583 |
PDHK3_TYR |
0.674 | 0.048 | 4 | 0.904 |
ALPHAK3 |
0.671 | -0.042 | -1 | 0.776 |
TAO1 |
0.671 | -0.099 | 1 | 0.100 |
CK1A |
0.671 | -0.068 | -3 | 0.210 |
ROCK1 |
0.670 | -0.084 | -3 | 0.340 |
MYO3B |
0.669 | -0.096 | 2 | 0.825 |
ASK1 |
0.668 | -0.140 | 1 | 0.103 |
TESK1_TYR |
0.667 | -0.021 | 3 | 0.762 |
RIPK2 |
0.667 | -0.247 | 1 | 0.077 |
MYO3A |
0.666 | -0.099 | 1 | 0.101 |
PDHK4_TYR |
0.666 | -0.002 | 2 | 0.880 |
MAP2K6_TYR |
0.666 | 0.025 | -1 | 0.874 |
LIMK2_TYR |
0.665 | 0.025 | -3 | 0.412 |
TXK |
0.665 | 0.062 | 1 | 0.091 |
MAP2K4_TYR |
0.665 | -0.017 | -1 | 0.880 |
PKG1 |
0.664 | -0.108 | -2 | 0.461 |
PKMYT1_TYR |
0.663 | 0.026 | 3 | 0.723 |
MAP2K7_TYR |
0.661 | -0.104 | 2 | 0.848 |
PDHK1_TYR |
0.661 | -0.043 | -1 | 0.887 |
BMPR2_TYR |
0.660 | 0.011 | -1 | 0.849 |
RET |
0.660 | -0.053 | 1 | 0.118 |
YES1 |
0.660 | 0.043 | -1 | 0.875 |
PINK1_TYR |
0.659 | -0.109 | 1 | 0.151 |
CSF1R |
0.658 | 0.002 | 3 | 0.657 |
CK1G3 |
0.656 | -0.075 | -3 | 0.181 |
STLK3 |
0.655 | -0.154 | 1 | 0.077 |
YANK3 |
0.655 | -0.078 | 2 | 0.381 |
LIMK1_TYR |
0.654 | -0.065 | 2 | 0.843 |
ABL2 |
0.654 | -0.013 | -1 | 0.834 |
LCK |
0.654 | 0.019 | -1 | 0.838 |
BLK |
0.653 | 0.028 | -1 | 0.840 |
NEK10_TYR |
0.653 | -0.095 | 1 | 0.103 |
TYRO3 |
0.652 | -0.092 | 3 | 0.669 |
JAK2 |
0.652 | -0.107 | 1 | 0.128 |
MST1R |
0.651 | -0.104 | 3 | 0.669 |
EPHB4 |
0.651 | -0.054 | -1 | 0.834 |
EPHA6 |
0.651 | -0.056 | -1 | 0.848 |
FGR |
0.651 | -0.076 | 1 | 0.091 |
TYK2 |
0.651 | -0.169 | 1 | 0.105 |
FYN |
0.650 | 0.054 | -1 | 0.808 |
FGFR2 |
0.650 | 0.008 | 3 | 0.642 |
ABL1 |
0.650 | -0.029 | -1 | 0.834 |
ROS1 |
0.649 | -0.113 | 3 | 0.643 |
KIT |
0.649 | -0.041 | 3 | 0.653 |
FER |
0.649 | -0.058 | 1 | 0.102 |
HCK |
0.648 | -0.043 | -1 | 0.838 |
SRMS |
0.647 | -0.039 | 1 | 0.081 |
ITK |
0.647 | -0.052 | -1 | 0.819 |
INSRR |
0.647 | -0.061 | 3 | 0.611 |
JAK3 |
0.647 | -0.103 | 1 | 0.114 |
FLT3 |
0.647 | -0.065 | 3 | 0.667 |
JAK1 |
0.646 | -0.092 | 1 | 0.103 |
TEK |
0.645 | -0.017 | 3 | 0.597 |
FGFR1 |
0.644 | -0.030 | 3 | 0.614 |
TEC |
0.643 | -0.042 | -1 | 0.781 |
EPHA4 |
0.643 | -0.054 | 2 | 0.754 |
BMX |
0.642 | -0.043 | -1 | 0.740 |
EGFR |
0.642 | -0.008 | 1 | 0.078 |
KDR |
0.642 | -0.074 | 3 | 0.615 |
DDR1 |
0.642 | -0.162 | 4 | 0.823 |
EPHB2 |
0.642 | -0.049 | -1 | 0.812 |
TNK1 |
0.641 | -0.106 | 3 | 0.655 |
TNNI3K_TYR |
0.641 | -0.080 | 1 | 0.131 |
FGFR3 |
0.641 | -0.002 | 3 | 0.617 |
BTK |
0.641 | -0.062 | -1 | 0.805 |
TNK2 |
0.641 | -0.132 | 3 | 0.603 |
MET |
0.640 | -0.050 | 3 | 0.634 |
MERTK |
0.640 | -0.079 | 3 | 0.619 |
EPHB1 |
0.640 | -0.110 | 1 | 0.088 |
PDGFRB |
0.640 | -0.139 | 3 | 0.664 |
FRK |
0.639 | -0.027 | -1 | 0.850 |
SRC |
0.639 | 0.015 | -1 | 0.821 |
ERBB2 |
0.638 | -0.071 | 1 | 0.095 |
LYN |
0.637 | -0.006 | 3 | 0.581 |
EPHB3 |
0.636 | -0.119 | -1 | 0.819 |
MATK |
0.636 | -0.018 | -1 | 0.769 |
WEE1_TYR |
0.636 | -0.083 | -1 | 0.789 |
FLT1 |
0.635 | -0.080 | -1 | 0.804 |
PTK6 |
0.635 | -0.071 | -1 | 0.768 |
AXL |
0.635 | -0.138 | 3 | 0.615 |
FGFR4 |
0.635 | -0.004 | -1 | 0.771 |
ALK |
0.633 | -0.101 | 3 | 0.583 |
PTK2B |
0.633 | -0.049 | -1 | 0.823 |
CK1G2 |
0.633 | -0.069 | -3 | 0.240 |
PDGFRA |
0.632 | -0.172 | 3 | 0.658 |
CSK |
0.632 | -0.005 | 2 | 0.753 |
NTRK1 |
0.632 | -0.120 | -1 | 0.814 |
EPHA8 |
0.632 | -0.024 | -1 | 0.791 |
SYK |
0.631 | -0.008 | -1 | 0.726 |
EPHA7 |
0.631 | -0.090 | 2 | 0.756 |
LTK |
0.631 | -0.102 | 3 | 0.602 |
INSR |
0.631 | -0.098 | 3 | 0.599 |
NTRK3 |
0.630 | -0.087 | -1 | 0.765 |
DDR2 |
0.630 | -0.088 | 3 | 0.592 |
FLT4 |
0.629 | -0.111 | 3 | 0.605 |
YANK2 |
0.627 | -0.086 | 2 | 0.394 |
EPHA1 |
0.627 | -0.127 | 3 | 0.615 |
ERBB4 |
0.626 | -0.031 | 1 | 0.082 |
PTK2 |
0.626 | -0.014 | -1 | 0.733 |
EPHA5 |
0.626 | -0.072 | 2 | 0.743 |
NTRK2 |
0.626 | -0.158 | 3 | 0.583 |
EPHA3 |
0.624 | -0.127 | 2 | 0.729 |
MUSK |
0.621 | -0.108 | 1 | 0.064 |
ZAP70 |
0.619 | -0.027 | -1 | 0.661 |
IGF1R |
0.618 | -0.077 | 3 | 0.533 |
EPHA2 |
0.617 | -0.069 | -1 | 0.745 |
FES |
0.606 | -0.084 | -1 | 0.729 |