Motif 319 (n=179)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0A0MRY4 None S579 ochoa Spermatogenesis-associated protein 13 None
A0A0C4DFX4 None S3033 ochoa Snf2 related CREBBP activator protein None
A8MVW0 FAM171A2 S422 ochoa Protein FAM171A2 None
H3BQZ7 HNRNPUL2-BSCL2 S655 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 None
O00471 EXOC5 S378 ochoa Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
O00515 LAD1 S38 ochoa|psp Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.
O14646 CHD1 S1096 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14646 CHD1 S1098 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14646 CHD1 S1100 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O15085 ARHGEF11 S633 ochoa Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
O15234 CASC3 Y263 ochoa Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.
O43166 SIPA1L1 S174 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O60307 MAST3 S153 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60307 MAST3 S155 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60825 PFKFB2 S471 ochoa 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}.
O75420 GIGYF1 S155 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75494 SRSF10 S106 ochoa Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
O75494 SRSF10 S108 ochoa Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
O75494 SRSF10 S156 ochoa Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
O75494 SRSF10 S158 ochoa Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
O75494 SRSF10 S160 ochoa Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
O94875 SORBS2 S841 ochoa Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
O94880 PHF14 S835 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O94913 PCF11 S487 ochoa Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}.
O94913 PCF11 S489 ochoa Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}.
P08621 SNRNP70 S217 ochoa U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.
P08621 SNRNP70 Y219 ochoa U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.
P09629 HOXB7 S132 psp Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P14416 DRD2 S228 psp D(2) dopamine receptor (Dopamine D2 receptor) Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}.
P18583 SON S2029 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P18583 SON S2031 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P18615 NELFE S113 ochoa Negative elongation factor E (NELF-E) (RNA-binding protein RD) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
P18825 ADRA2C S352 ochoa Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
P21127 CDK11B S113 ochoa Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}.
P23588 EIF4B S71 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P23588 EIF4B S263 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P23588 EIF4B S309 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P23588 EIF4B S312 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P25054 APC S2531 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P25054 APC S2533 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P30414 NKTR S406 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P36915 GNL1 S32 ochoa Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) Possible regulatory or functional link with the histocompatibility cluster.
P38159 RBMX S249 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P40818 USP8 S716 ochoa Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}.
P41587 VIPR2 S409 ochoa Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C. {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:7811244, ECO:0000269|PubMed:8933357}.
P48634 PRRC2A S456 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48634 PRRC2A S1384 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49815 TSC2 S937 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P51114 FXR1 S494 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
P52756 RBM5 Y51 ochoa RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}.
P53804 TTC3 S376 ochoa E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}.
P58340 MLF1 S32 ochoa Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.
P83369 LSM11 S278 ochoa U7 snRNA-associated Sm-like protein LSm11 Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750). {ECO:0000250|UniProtKB:Q8BUV6, ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:16914750, ECO:0000269|PubMed:33230297}.
Q02040 AKAP17A S638 ochoa A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}.
Q02241 KIF23 S812 psp Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}.
Q03113 GNA12 S40 ochoa Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:22609986, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:16705036, PubMed:16787920, PubMed:23762476, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:15980433, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:17565996, ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:23762476, ECO:0000269|PubMed:27084452}.
Q04637 EIF4G1 S1185 ochoa|psp Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.
Q08043 ACTN3 S319 ochoa Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Q12873 CHD3 S88 ochoa Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.
Q13243 SRSF5 S250 ochoa Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Q13415 ORC1 S476 ochoa Origin recognition complex subunit 1 (Replication control protein 1) Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Q13427 PPIG S356 ochoa Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}.
Q13523 PRP4K S292 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q13523 PRP4K S294 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q13523 PRP4K S368 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q13523 PRP4K S381 ochoa Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
Q14152 EIF3A S1263 ochoa Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
Q14153 FAM53B S266 ochoa Protein FAM53B (Protein simplet) Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.
Q14315 FLNC S2181 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14493 SLBP S59 ochoa Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}.
Q14498 RBM39 Y95 ochoa|psp RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}.
Q14669 TRIP12 S159 ochoa E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}.
Q14676 MDC1 S1797 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14678 KANK1 S323 ochoa KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}.
Q14687 GSE1 S826 ochoa Genetic suppressor element 1 None
Q14739 LBR S67 ochoa Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}.
Q14739 LBR S69 ochoa Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}.
Q14739 LBR S84 ochoa Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}.
Q14966 ZNF638 S558 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q15032 R3HDM1 S280 ochoa R3H domain-containing protein 1 None
Q15772 SPEG S417 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q16629 SRSF7 S123 ochoa Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}.
Q16629 SRSF7 S198 ochoa Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}.
Q1KMD3 HNRNPUL2 S655 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) None
Q32MZ4 LRRFIP1 S66 ochoa Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Q5T200 ZC3H13 S108 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5T200 ZC3H13 S316 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q6JBY9 RCSD1 S177 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6PJF5 RHBDF2 S113 ochoa Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}.
Q6PJF5 RHBDF2 S385 ochoa Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}.
Q6VMQ6 ATF7IP S557 ochoa Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.
Q6Y7W6 GIGYF2 S158 ochoa GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.
Q6Y7W6 GIGYF2 S273 ochoa GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.
Q6ZRS2 SRCAP S3210 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZSZ5 ARHGEF18 S83 ochoa Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}.
Q7L4I2 RSRC2 S30 ochoa Arginine/serine-rich coiled-coil protein 2 None
Q7L4I2 RSRC2 S32 ochoa Arginine/serine-rich coiled-coil protein 2 None
Q7Z3G6 PRICKLE2 S693 ochoa Prickle-like protein 2 None
Q7Z403 TMC6 S112 ochoa Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q7TN60, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}.
Q86SG6 NEK8 S280 ochoa Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (PubMed:37598857). Plays a role in organogenesis, and is involved in the regulation of the Hippo signaling pathway (PubMed:26967905). {ECO:0000269|PubMed:23418306, ECO:0000269|PubMed:26967905, ECO:0000269|PubMed:37598857}.
Q86SU0 ILDR1 S467 ochoa Immunoglobulin-like domain-containing receptor 1 (Angulin-2) Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:Q8CBR1, ECO:0000269|PubMed:23239027}.; FUNCTION: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity. {ECO:0000269|PubMed:35595813}.
Q86U06 RBM23 Y126 ochoa Probable RNA-binding protein 23 (CAPER beta) (CAPERbeta) (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2) RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}.
Q86X51 EZHIP S336 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q86YR5 GPSM1 S469 ochoa G-protein-signaling modulator 1 (Activator of G-protein signaling 3) Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.
Q8N3D4 EHBP1L1 S1273 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N4S9 MARVELD2 S387 ochoa MARVEL domain-containing protein 2 (Tricellulin) Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}.
Q8NCN4 RNF169 S290 ochoa E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}.
Q8NEV8 EXPH5 S1851 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NFC6 BOD1L1 S2954 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8TEA8 DTD1 S179 psp D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.
Q8WUQ7 CACTIN S71 ochoa Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851). Involved in the regulation of innate immune response (PubMed:20829348). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554). {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}.
Q8WX93 PALLD S1101 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WX93 PALLD S1118 ochoa|psp Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q92576 PHF3 S1952 ochoa PHD finger protein 3 None
Q92620 DHX38 S119 ochoa Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}.
Q92997 DVL3 S232 psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q93100 PHKB S25 ochoa Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.
Q96E39 RBMXL1 S249 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96F86 EDC3 S233 ochoa Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}.
Q96G01 BICD1 S546 ochoa Protein bicaudal D homolog 1 (Bic-D 1) Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Q96GE4 CEP95 S451 ochoa Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) None
Q96I25 RBM17 S169 ochoa Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.
Q96N96 SPATA13 S76 ochoa Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
Q96QT4 TRPM7 S552 ochoa Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96T23 RSF1 S1221 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q96T58 SPEN S188 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99590 SCAF11 S848 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q9BRD0 BUD13 S402 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BU76 MMTAG2 S233 ochoa Multiple myeloma tumor-associated protein 2 (hMMTAG2) None
Q9BUQ8 DDX23 S107 ochoa Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}.
Q9BXP5 SRRT S51 ochoa Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}.
Q9GZY8 MFF S155 ochoa|psp Mitochondrial fission factor Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
Q9H425 C1orf198 S35 ochoa Uncharacterized protein C1orf198 None
Q9H4L4 SENP3 S139 psp Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H4L4 SENP3 S141 psp Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H9J4 USP42 S1170 ochoa Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9HCB6 SPON1 S740 ochoa Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.
Q9HCG8 CWC22 S61 ochoa Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
Q9HCG8 CWC22 S91 ochoa Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
Q9HCS5 EPB41L4A S541 ochoa Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) None
Q9NVW2 RLIM S228 ochoa E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Q9NVW2 RLIM S230 ochoa|psp E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Q9NW75 GPATCH2 S54 ochoa G patch domain-containing protein 2 Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.
Q9NW75 GPATCH2 S56 ochoa G patch domain-containing protein 2 Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.
Q9NW75 GPATCH2 S146 ochoa G patch domain-containing protein 2 Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}.
Q9NWB6 ARGLU1 S56 ochoa Arginine and glutamate-rich protein 1 Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:27899669, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}.
Q9NWB6 ARGLU1 S58 ochoa Arginine and glutamate-rich protein 1 Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:27899669, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}.
Q9NWB6 ARGLU1 S60 ochoa Arginine and glutamate-rich protein 1 Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:27899669, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}.
Q9NYF3 FAM53C S271 ochoa Protein FAM53C None
Q9NYJ8 TAB2 S580 ochoa TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}.
Q9NZM1 MYOF S727 ochoa Myoferlin (Fer-1-like protein 3) Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.
Q9P1Y6 PHRF1 S1032 ochoa PHD and RING finger domain-containing protein 1 None
Q9P1Y6 PHRF1 S1091 ochoa PHD and RING finger domain-containing protein 1 None
Q9P1Y6 PHRF1 S1093 ochoa PHD and RING finger domain-containing protein 1 None
Q9P1Y6 PHRF1 S1127 ochoa PHD and RING finger domain-containing protein 1 None
Q9P1Y6 PHRF1 S1165 ochoa PHD and RING finger domain-containing protein 1 None
Q9UBK2 PPARGC1A S571 psp Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}.
Q9UBL0 ARPP21 S278 ochoa cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.
Q9UKJ3 GPATCH8 S1028 ochoa G patch domain-containing protein 8 None
Q9UKJ3 GPATCH8 S1033 ochoa G patch domain-containing protein 8 None
Q9UKV3 ACIN1 S1161 ochoa Apoptotic chromatin condensation inducer in the nucleus (Acinus) Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.
Q9UPA5 BSN S1090 ochoa Protein bassoon (Zinc finger protein 231) Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.
Q9UQ35 SRRM2 S142 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S248 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S484 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S486 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S534 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2H9 MAST1 S161 ochoa Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}.
Q9Y2L6 FRMD4B S675 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y383 LUC7L2 S370 ochoa Putative RNA-binding protein Luc7-like 2 May bind to RNA via its Arg/Ser-rich domain.
Q9Y3X0 CCDC9 S202 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y520 PRRC2C S1542 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y5Y4 PTGDR2 S350 ochoa Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
Q14152 EIF3A S1256 Sugiyama Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
Q14152 EIF3A S1258 Sugiyama Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
Q92785 DPF2 S68 Sugiyama Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.
P51957 NEK4 S531 Sugiyama Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
Q14C86 GAPVD1 S900 Sugiyama GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}.
Q00975 CACNA1B S2120 SIGNOR Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling (PubMed:25296916). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). {ECO:0000250|UniProtKB:Q02294, ECO:0000269|PubMed:25296916}.; FUNCTION: [Isoform Alpha-1B-1]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. {ECO:0000269|PubMed:1321501}.
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reactome_id name p -log10_p
R-HSA-72163 mRNA Splicing - Major Pathway 6.883383e-14 13.162
R-HSA-72172 mRNA Splicing 1.655343e-13 12.781
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.876588e-13 12.541
R-HSA-8953854 Metabolism of RNA 2.884913e-08 7.540
R-HSA-73856 RNA Polymerase II Transcription Termination 3.035937e-06 5.518
R-HSA-72187 mRNA 3'-end processing 2.039197e-04 3.691
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 1.256971e-03 2.901
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.441168e-03 2.612
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 4.324143e-03 2.364
R-HSA-111465 Apoptotic cleavage of cellular proteins 4.715749e-03 2.326
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.851853e-03 2.233
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 7.192494e-03 2.143
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 8.718179e-03 2.060
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 8.891463e-03 2.051
R-HSA-165159 MTOR signalling 9.958528e-03 2.002
R-HSA-75153 Apoptotic execution phase 1.223296e-02 1.912
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 4.284263e-02 1.368
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 4.284263e-02 1.368
R-HSA-165181 Inhibition of TSC complex formation by PKB 5.118988e-02 1.291
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 5.946485e-02 1.226
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 7.580041e-02 1.120
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 7.580041e-02 1.120
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 8.386223e-02 1.076
R-HSA-201688 WNT mediated activation of DVL 9.977699e-02 1.001
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.076311e-01 0.968
R-HSA-4839744 Signaling by APC mutants 1.154172e-01 0.938
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.154172e-01 0.938
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.154172e-01 0.938
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.154172e-01 0.938
R-HSA-112308 Presynaptic depolarization and calcium channel opening 1.154172e-01 0.938
R-HSA-429947 Deadenylation of mRNA 2.887604e-02 1.539
R-HSA-5339716 Signaling by GSK3beta mutants 1.231358e-01 0.910
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.307876e-01 0.883
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.307876e-01 0.883
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.307876e-01 0.883
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.307876e-01 0.883
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.307876e-01 0.883
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 1.533473e-01 0.814
R-HSA-196299 Beta-catenin phosphorylation cascade 1.533473e-01 0.814
R-HSA-390522 Striated Muscle Contraction 4.853180e-02 1.314
R-HSA-72649 Translation initiation complex formation 1.760809e-02 1.754
R-HSA-72702 Ribosomal scanning and start codon recognition 1.912650e-02 1.718
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.896621e-01 0.722
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.967373e-01 0.706
R-HSA-72165 mRNA Splicing - Minor Pathway 8.181797e-02 1.087
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.511742e-01 0.600
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.511742e-01 0.600
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.201125e-01 0.920
R-HSA-167287 HIV elongation arrest and recovery 2.577159e-01 0.589
R-HSA-167290 Pausing and recovery of HIV elongation 2.577159e-01 0.589
R-HSA-5083635 Defective B3GALTL causes PpS 2.895831e-01 0.538
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.957917e-01 0.529
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.587683e-01 0.799
R-HSA-380287 Centrosome maturation 1.649085e-01 0.783
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 3.200916e-01 0.495
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 3.377684e-01 0.471
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.958736e-01 0.529
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.958736e-01 0.529
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 3.377684e-01 0.471
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 2.071527e-02 1.684
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 3.319274e-01 0.479
R-HSA-68962 Activation of the pre-replicative complex 2.706296e-01 0.568
R-HSA-416482 G alpha (12/13) signalling events 4.046232e-02 1.393
R-HSA-167169 HIV Transcription Elongation 3.377684e-01 0.471
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.435483e-02 1.464
R-HSA-9664420 Killing mechanisms 1.607373e-01 0.794
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.607373e-01 0.794
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 3.019463e-01 0.520
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5.946485e-02 1.226
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.680632e-01 0.775
R-HSA-9930044 Nuclear RNA decay 2.895831e-01 0.538
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.861954e-01 0.543
R-HSA-9842860 Regulation of endogenous retroelements 7.772041e-02 1.109
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 2.409673e-01 0.618
R-HSA-9843745 Adipogenesis 1.391876e-01 0.856
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 6.443705e-02 1.191
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 6.443705e-02 1.191
R-HSA-4791275 Signaling by WNT in cancer 2.833203e-01 0.548
R-HSA-72737 Cap-dependent Translation Initiation 1.066875e-01 0.972
R-HSA-72613 Eukaryotic Translation Initiation 1.066875e-01 0.972
R-HSA-390651 Dopamine receptors 5.118988e-02 1.291
R-HSA-68689 CDC6 association with the ORC:origin complex 6.766815e-02 1.170
R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 1.076311e-01 0.968
R-HSA-4839748 Signaling by AMER1 mutants 1.231358e-01 0.910
R-HSA-4839735 Signaling by AXIN mutants 1.231358e-01 0.910
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 1.533473e-01 0.814
R-HSA-429914 Deadenylation-dependent mRNA decay 2.153608e-02 1.667
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.080475e-01 0.511
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.140958e-01 0.503
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 3.319274e-01 0.479
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.377684e-01 0.471
R-HSA-68616 Assembly of the ORC complex at the origin of replication 2.895831e-01 0.538
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.825250e-01 0.739
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 1.496434e-01 0.825
R-HSA-4641258 Degradation of DVL 3.200916e-01 0.495
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 9.977699e-02 1.001
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 1.458928e-01 0.836
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.458928e-01 0.836
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.533473e-01 0.814
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 2.577159e-01 0.589
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 1.307876e-01 0.883
R-HSA-212165 Epigenetic regulation of gene expression 1.834795e-01 0.736
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 1.680632e-01 0.775
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.037511e-01 0.691
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 2.445752e-01 0.612
R-HSA-113418 Formation of the Early Elongation Complex 2.577159e-01 0.589
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.917885e-02 1.050
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 8.917885e-02 1.050
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 3.377684e-01 0.471
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.772597e-01 0.423
R-HSA-9932444 ATP-dependent chromatin remodelers 2.379185e-01 0.624
R-HSA-9932451 SWI/SNF chromatin remodelers 2.379185e-01 0.624
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 6.683528e-02 1.175
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.967373e-01 0.706
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.107041e-01 0.676
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.706296e-01 0.568
R-HSA-8856688 Golgi-to-ER retrograde transport 3.722098e-01 0.429
R-HSA-5655302 Signaling by FGFR1 in disease 3.492987e-01 0.457
R-HSA-201681 TCF dependent signaling in response to WNT 2.606284e-01 0.584
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 4.284263e-02 1.368
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 8.386223e-02 1.076
R-HSA-166208 mTORC1-mediated signalling 2.543958e-02 1.594
R-HSA-68884 Mitotic Telophase/Cytokinesis 1.231358e-01 0.910
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 1.607373e-01 0.794
R-HSA-113510 E2F mediated regulation of DNA replication 1.896621e-01 0.722
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.717646e-01 0.430
R-HSA-774815 Nucleosome assembly 3.717646e-01 0.430
R-HSA-1839124 FGFR1 mutant receptor activation 2.895831e-01 0.538
R-HSA-9662834 CD163 mediating an anti-inflammatory response 1.154172e-01 0.938
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2.706296e-01 0.568
R-HSA-176187 Activation of ATR in response to replication stress 2.895831e-01 0.538
R-HSA-168638 NOD1/2 Signaling Pathway 3.019463e-01 0.520
R-HSA-8863795 Downregulation of ERBB2 signaling 2.706296e-01 0.568
R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 1.154172e-01 0.938
R-HSA-5620916 VxPx cargo-targeting to cilium 1.967373e-01 0.706
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 2.107041e-01 0.676
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.511742e-01 0.600
R-HSA-70221 Glycogen breakdown (glycogenolysis) 2.379185e-01 0.624
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 2.706296e-01 0.568
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.025115e-01 0.694
R-HSA-1251985 Nuclear signaling by ERBB4 3.377684e-01 0.471
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.717646e-01 0.430
R-HSA-390696 Adrenoceptors 9.185423e-02 1.037
R-HSA-4641263 Regulation of FZD by ubiquitination 1.753256e-01 0.756
R-HSA-73762 RNA Polymerase I Transcription Initiation 3.549889e-01 0.450
R-HSA-69481 G2/M Checkpoints 3.533739e-01 0.452
R-HSA-69206 G1/S Transition 3.470517e-01 0.460
R-HSA-6794361 Neurexins and neuroligins 9.771623e-02 1.010
R-HSA-400685 Sema4D in semaphorin signaling 2.379185e-01 0.624
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 3.492987e-01 0.457
R-HSA-193648 NRAGE signals death through JNK 1.087583e-01 0.964
R-HSA-3295583 TRP channels 2.445752e-01 0.612
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.200916e-01 0.495
R-HSA-9816359 Maternal to zygotic transition (MZT) 3.375316e-01 0.472
R-HSA-69278 Cell Cycle, Mitotic 2.561019e-01 0.592
R-HSA-70635 Urea cycle 2.445752e-01 0.612
R-HSA-420092 Glucagon-type ligand receptors 2.642009e-01 0.578
R-HSA-5689880 Ub-specific processing proteases 2.373082e-01 0.625
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 3.827071e-01 0.417
R-HSA-1640170 Cell Cycle 1.903576e-01 0.720
R-HSA-391908 Prostanoid ligand receptors 1.154172e-01 0.938
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.307876e-01 0.883
R-HSA-375280 Amine ligand-binding receptors 7.671519e-02 1.115
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 9.977699e-02 1.001
R-HSA-446353 Cell-extracellular matrix interactions 1.533473e-01 0.814
R-HSA-6807062 Cholesterol biosynthesis via lathosterol 2.175968e-01 0.662
R-HSA-6794362 Protein-protein interactions at synapses 1.961690e-01 0.707
R-HSA-3214841 PKMTs methylate histone lysines 3.435587e-01 0.464
R-HSA-9007101 Rab regulation of trafficking 3.183752e-01 0.497
R-HSA-6807004 Negative regulation of MET activity 1.967373e-01 0.706
R-HSA-9671555 Signaling by PDGFR in disease 2.107041e-01 0.676
R-HSA-8982491 Glycogen metabolism 3.377684e-01 0.471
R-HSA-5688426 Deubiquitination 2.218589e-01 0.654
R-HSA-373753 Nephrin family interactions 1.967373e-01 0.706
R-HSA-69205 G1/S-Specific Transcription 5.515200e-02 1.258
R-HSA-9022692 Regulation of MECP2 expression and activity 2.895831e-01 0.538
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.895831e-01 0.538
R-HSA-5689896 Ovarian tumor domain proteases 3.200916e-01 0.495
R-HSA-8854214 TBC/RABGAPs 3.606296e-01 0.443
R-HSA-74160 Gene expression (Transcription) 3.803011e-01 0.420
R-HSA-391903 Eicosanoid ligand-binding receptors 1.967373e-01 0.706
R-HSA-191273 Cholesterol biosynthesis 1.741956e-01 0.759
R-HSA-1169408 ISG15 antiviral mechanism 1.649085e-01 0.783
R-HSA-9018519 Estrogen-dependent gene expression 4.632636e-02 1.334
R-HSA-264876 Insulin processing 2.511742e-01 0.600
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.587683e-01 0.799
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 2.244298e-01 0.649
R-HSA-376176 Signaling by ROBO receptors 3.080223e-01 0.511
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.717646e-01 0.430
R-HSA-8939211 ESR-mediated signaling 1.894154e-01 0.723
R-HSA-3700989 Transcriptional Regulation by TP53 2.540539e-01 0.595
R-HSA-5683826 Surfactant metabolism 3.662214e-01 0.436
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.080475e-01 0.511
R-HSA-109581 Apoptosis 2.098679e-01 0.678
R-HSA-193704 p75 NTR receptor-mediated signalling 2.506489e-01 0.601
R-HSA-73887 Death Receptor Signaling 1.920026e-01 0.717
R-HSA-5357801 Programmed Cell Death 3.151776e-01 0.501
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.881071e-01 0.411
R-HSA-68949 Orc1 removal from chromatin 4.092422e-01 0.388
R-HSA-112382 Formation of RNA Pol II elongation complex 4.092422e-01 0.388
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 4.092422e-01 0.388
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.144117e-01 0.383
R-HSA-4839726 Chromatin organization 4.193819e-01 0.377
R-HSA-453279 Mitotic G1 phase and G1/S transition 4.212944e-01 0.375
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 4.246164e-01 0.372
R-HSA-3214815 HDACs deacetylate histones 4.246164e-01 0.372
R-HSA-418597 G alpha (z) signalling events 4.246164e-01 0.372
R-HSA-75893 TNF signaling 4.296523e-01 0.367
R-HSA-9006931 Signaling by Nuclear Receptors 4.324030e-01 0.364
R-HSA-9856651 MITF-M-dependent gene expression 4.332663e-01 0.363
R-HSA-73857 RNA Polymerase II Transcription 4.336193e-01 0.363
R-HSA-2980766 Nuclear Envelope Breakdown 4.346444e-01 0.362
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.392031e-01 0.357
R-HSA-69620 Cell Cycle Checkpoints 4.401821e-01 0.356
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 4.444989e-01 0.352
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.451063e-01 0.352
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.451063e-01 0.352
R-HSA-983189 Kinesins 4.493620e-01 0.347
R-HSA-8943724 Regulation of PTEN gene transcription 4.493620e-01 0.347
R-HSA-1227986 Signaling by ERBB2 4.493620e-01 0.347
R-HSA-8939902 Regulation of RUNX2 expression and activity 4.541829e-01 0.343
R-HSA-450294 MAP kinase activation 4.541829e-01 0.343
R-HSA-9707616 Heme signaling 4.589618e-01 0.338
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.636991e-01 0.334
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.636991e-01 0.334
R-HSA-373755 Semaphorin interactions 4.636991e-01 0.334
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 4.636991e-01 0.334
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 4.683953e-01 0.329
R-HSA-68886 M Phase 4.709900e-01 0.327
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 4.730507e-01 0.325
R-HSA-76002 Platelet activation, signaling and aggregation 4.764358e-01 0.322
R-HSA-8854518 AURKA Activation by TPX2 4.776655e-01 0.321
R-HSA-5693606 DNA Double Strand Break Response 4.822403e-01 0.317
R-HSA-167172 Transcription of the HIV genome 4.867752e-01 0.313
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 4.867752e-01 0.313
R-HSA-195253 Degradation of beta-catenin by the destruction complex 4.957272e-01 0.305
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.957272e-01 0.305
R-HSA-448424 Interleukin-17 signaling 4.957272e-01 0.305
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.001448e-01 0.301
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 5.001448e-01 0.301
R-HSA-5620920 Cargo trafficking to the periciliary membrane 5.001448e-01 0.301
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.045240e-01 0.297
R-HSA-372790 Signaling by GPCR 5.054771e-01 0.296
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.063220e-01 0.296
R-HSA-69052 Switching of origins to a post-replicative state 5.088651e-01 0.293
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.088651e-01 0.293
R-HSA-674695 RNA Polymerase II Pre-transcription Events 5.131685e-01 0.290
R-HSA-69473 G2/M DNA damage checkpoint 5.131685e-01 0.290
R-HSA-1236394 Signaling by ERBB4 5.131685e-01 0.290
R-HSA-1226099 Signaling by FGFR in disease 5.131685e-01 0.290
R-HSA-73854 RNA Polymerase I Promoter Clearance 5.216632e-01 0.283
R-HSA-195721 Signaling by WNT 5.287052e-01 0.277
R-HSA-4086400 PCP/CE pathway 5.300107e-01 0.276
R-HSA-73864 RNA Polymerase I Transcription 5.300107e-01 0.276
R-HSA-9659379 Sensory processing of sound 5.341301e-01 0.272
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 5.341301e-01 0.272
R-HSA-69275 G2/M Transition 5.371948e-01 0.270
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.382136e-01 0.269
R-HSA-6806834 Signaling by MET 5.382136e-01 0.269
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 5.422615e-01 0.266
R-HSA-5693607 Processing of DNA double-strand break ends 5.422615e-01 0.266
R-HSA-453274 Mitotic G2-G2/M phases 5.424331e-01 0.266
R-HSA-5617833 Cilium Assembly 5.476306e-01 0.262
R-HSA-388396 GPCR downstream signalling 5.481364e-01 0.261
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 5.541952e-01 0.256
R-HSA-68877 Mitotic Prometaphase 5.553500e-01 0.255
R-HSA-6802957 Oncogenic MAPK signaling 5.581041e-01 0.253
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 5.619789e-01 0.250
R-HSA-141424 Amplification of signal from the kinetochores 5.619789e-01 0.250
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 5.619789e-01 0.250
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 5.730003e-01 0.242
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.734020e-01 0.242
R-HSA-1852241 Organelle biogenesis and maintenance 5.740114e-01 0.241
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.808527e-01 0.236
R-HSA-202424 Downstream TCR signaling 5.808527e-01 0.236
R-HSA-373080 Class B/2 (Secretin family receptors) 5.808527e-01 0.236
R-HSA-8986944 Transcriptional Regulation by MECP2 5.845294e-01 0.233
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 5.881740e-01 0.230
R-HSA-68867 Assembly of the pre-replicative complex 5.953684e-01 0.225
R-HSA-397014 Muscle contraction 6.044263e-01 0.219
R-HSA-72689 Formation of a pool of free 40S subunits 6.059267e-01 0.218
R-HSA-9730414 MITF-M-regulated melanocyte development 6.067706e-01 0.217
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 6.093850e-01 0.215
R-HSA-5607764 CLEC7A (Dectin-1) signaling 6.093850e-01 0.215
R-HSA-170834 Signaling by TGF-beta Receptor Complex 6.128131e-01 0.213
R-HSA-68882 Mitotic Anaphase 6.137407e-01 0.212
R-HSA-2555396 Mitotic Metaphase and Anaphase 6.160432e-01 0.210
R-HSA-975871 MyD88 cascade initiated on plasma membrane 6.162114e-01 0.210
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 6.162114e-01 0.210
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 6.162114e-01 0.210
R-HSA-422356 Regulation of insulin secretion 6.162114e-01 0.210
R-HSA-9614085 FOXO-mediated transcription 6.195800e-01 0.208
R-HSA-69618 Mitotic Spindle Checkpoint 6.229193e-01 0.206
R-HSA-70171 Glycolysis 6.229193e-01 0.206
R-HSA-9020702 Interleukin-1 signaling 6.262295e-01 0.203
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.423525e-01 0.192
R-HSA-9692914 SARS-CoV-1-host interactions 6.454932e-01 0.190
R-HSA-69239 Synthesis of DNA 6.486066e-01 0.188
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.516928e-01 0.186
R-HSA-2672351 Stimuli-sensing channels 6.516928e-01 0.186
R-HSA-3247509 Chromatin modifying enzymes 6.535959e-01 0.185
R-HSA-69002 DNA Replication Pre-Initiation 6.547521e-01 0.184
R-HSA-975155 MyD88 dependent cascade initiated on endosome 6.547521e-01 0.184
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 6.577848e-01 0.182
R-HSA-166166 MyD88-independent TLR4 cascade 6.577848e-01 0.182
R-HSA-202403 TCR signaling 6.577848e-01 0.182
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 6.667248e-01 0.176
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 6.696530e-01 0.174
R-HSA-162582 Signal Transduction 6.753008e-01 0.171
R-HSA-5628897 TP53 Regulates Metabolic Genes 6.754330e-01 0.170
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.754330e-01 0.170
R-HSA-1592230 Mitochondrial biogenesis 6.839151e-01 0.165
R-HSA-70326 Glucose metabolism 6.839151e-01 0.165
R-HSA-2980736 Peptide hormone metabolism 6.839151e-01 0.165
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.866933e-01 0.163
R-HSA-5693538 Homology Directed Repair 6.866933e-01 0.163
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.894473e-01 0.161
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.894473e-01 0.161
R-HSA-8878166 Transcriptional regulation by RUNX2 6.894473e-01 0.161
R-HSA-68875 Mitotic Prophase 6.921772e-01 0.160
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.948832e-01 0.158
R-HSA-73886 Chromosome Maintenance 6.948832e-01 0.158
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.975657e-01 0.156
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.975657e-01 0.156
R-HSA-2132295 MHC class II antigen presentation 7.002247e-01 0.155
R-HSA-199991 Membrane Trafficking 7.009952e-01 0.154
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 7.069090e-01 0.151
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.080633e-01 0.150
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.080633e-01 0.150
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.080633e-01 0.150
R-HSA-114608 Platelet degranulation 7.131757e-01 0.147
R-HSA-418594 G alpha (i) signalling events 7.264306e-01 0.139
R-HSA-9909396 Circadian clock 7.279854e-01 0.138
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.303788e-01 0.136
R-HSA-422475 Axon guidance 7.337328e-01 0.134
R-HSA-3858494 Beta-catenin independent WNT signaling 7.397450e-01 0.131
R-HSA-163685 Integration of energy metabolism 7.397450e-01 0.131
R-HSA-5173105 O-linked glycosylation 7.420356e-01 0.130
R-HSA-9658195 Leishmania infection 7.423240e-01 0.129
R-HSA-9824443 Parasitic Infection Pathways 7.423240e-01 0.129
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 7.439830e-01 0.128
R-HSA-6807070 PTEN Regulation 7.465570e-01 0.127
R-HSA-1632852 Macroautophagy 7.509996e-01 0.124
R-HSA-162599 Late Phase of HIV Life Cycle 7.553649e-01 0.122
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 7.553649e-01 0.122
R-HSA-72766 Translation 7.571532e-01 0.121
R-HSA-8856828 Clathrin-mediated endocytosis 7.575190e-01 0.121
R-HSA-2871837 FCERI mediated NF-kB activation 7.596543e-01 0.119
R-HSA-1257604 PIP3 activates AKT signaling 7.647353e-01 0.116
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 7.680102e-01 0.115
R-HSA-69242 S Phase 7.680102e-01 0.115
R-HSA-9679191 Potential therapeutics for SARS 7.720793e-01 0.112
R-HSA-446652 Interleukin-1 family signaling 7.760776e-01 0.110
R-HSA-9675108 Nervous system development 7.775161e-01 0.109
R-HSA-69306 DNA Replication 7.780505e-01 0.109
R-HSA-5693532 DNA Double-Strand Break Repair 7.780505e-01 0.109
R-HSA-1989781 PPARA activates gene expression 7.819447e-01 0.107
R-HSA-9612973 Autophagy 7.838663e-01 0.106
R-HSA-500792 GPCR ligand binding 7.851339e-01 0.105
R-HSA-162587 HIV Life Cycle 7.857711e-01 0.105
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.857711e-01 0.105
R-HSA-9006936 Signaling by TGFB family members 7.913860e-01 0.102
R-HSA-5633007 Regulation of TP53 Activity 7.913860e-01 0.102
R-HSA-6798695 Neutrophil degranulation 7.922007e-01 0.101
R-HSA-1500931 Cell-Cell communication 7.951967e-01 0.100
R-HSA-2467813 Separation of Sister Chromatids 7.986459e-01 0.098
R-HSA-112316 Neuronal System 8.047827e-01 0.094
R-HSA-8957322 Metabolism of steroids 8.058600e-01 0.094
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 8.107521e-01 0.091
R-HSA-418555 G alpha (s) signalling events 8.124215e-01 0.090
R-HSA-5621481 C-type lectin receptors (CLRs) 8.124215e-01 0.090
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.157166e-01 0.088
R-HSA-9664433 Leishmania parasite growth and survival 8.157166e-01 0.088
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 8.189542e-01 0.087
R-HSA-9678108 SARS-CoV-1 Infection 8.189542e-01 0.087
R-HSA-9006925 Intracellular signaling by second messengers 8.280775e-01 0.082
R-HSA-3781865 Diseases of glycosylation 8.328383e-01 0.079
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.386646e-01 0.076
R-HSA-983712 Ion channel transport 8.400894e-01 0.076
R-HSA-168898 Toll-like Receptor Cascades 8.429016e-01 0.074
R-HSA-5653656 Vesicle-mediated transport 8.562832e-01 0.067
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8.587728e-01 0.066
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.713132e-01 0.060
R-HSA-913531 Interferon Signaling 8.713132e-01 0.060
R-HSA-9679506 SARS-CoV Infections 8.834680e-01 0.054
R-HSA-162906 HIV Infection 8.869046e-01 0.052
R-HSA-9705683 SARS-CoV-2-host interactions 8.879059e-01 0.052
R-HSA-72312 rRNA processing 8.918237e-01 0.050
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.230056e-01 0.035
R-HSA-109582 Hemostasis 9.258932e-01 0.033
R-HSA-446728 Cell junction organization 9.281930e-01 0.032
R-HSA-112315 Transmission across Chemical Synapses 9.519638e-01 0.021
R-HSA-9694516 SARS-CoV-2 Infection 9.619406e-01 0.017
R-HSA-73894 DNA Repair 9.655146e-01 0.015
R-HSA-212436 Generic Transcription Pathway 9.705463e-01 0.013
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 9.764778e-01 0.010
R-HSA-5668914 Diseases of metabolism 9.812835e-01 0.008
R-HSA-597592 Post-translational protein modification 9.834380e-01 0.007
R-HSA-392499 Metabolism of proteins 9.853400e-01 0.006
R-HSA-1280218 Adaptive Immune System 9.857997e-01 0.006
R-HSA-9824446 Viral Infection Pathways 9.918104e-01 0.004
R-HSA-1266738 Developmental Biology 9.922899e-01 0.003
R-HSA-168249 Innate Immune System 9.932471e-01 0.003
R-HSA-71291 Metabolism of amino acids and derivatives 9.966847e-01 0.001
R-HSA-449147 Signaling by Interleukins 9.968897e-01 0.001
R-HSA-1280215 Cytokine Signaling in Immune system 9.968906e-01 0.001
R-HSA-5663205 Infectious disease 9.981165e-01 0.001
R-HSA-1643685 Disease 9.993882e-01 0.000
R-HSA-382551 Transport of small molecules 9.998836e-01 0.000
R-HSA-168256 Immune System 9.998848e-01 0.000
R-HSA-556833 Metabolism of lipids 9.998857e-01 0.000
R-HSA-2262752 Cellular responses to stress 9.999176e-01 0.000
R-HSA-8953897 Cellular responses to stimuli 9.999750e-01 0.000
R-HSA-9709957 Sensory Perception 9.999896e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK2CLK2 0.830 0.444 -3 0.943
CLK3CLK3 0.826 0.390 1 0.804
RSK2RSK2 0.825 0.376 -3 0.962
SRPK1SRPK1 0.824 0.368 -3 0.952
RSK4RSK4 0.819 0.375 -3 0.936
PRKXPRKX 0.819 0.352 -3 0.888
RSK3RSK3 0.818 0.354 -3 0.962
SRPK2SRPK2 0.817 0.337 -3 0.923
AURCAURC 0.816 0.312 -2 0.736
P90RSKP90RSK 0.814 0.337 -3 0.965
PKACBPKACB 0.814 0.328 -2 0.753
CLK4CLK4 0.813 0.380 -3 0.958
PKACGPKACG 0.812 0.322 -2 0.812
NDR1NDR1 0.811 0.315 -3 0.947
P70S6KBP70S6KB 0.811 0.355 -3 0.968
CLK1CLK1 0.811 0.382 -3 0.948
PIM1PIM1 0.810 0.340 -3 0.947
PIM3PIM3 0.810 0.294 -3 0.949
NDR2NDR2 0.810 0.214 -3 0.925
HIPK4HIPK4 0.809 0.315 1 0.877
PRKD2PRKD2 0.808 0.318 -3 0.941
MSK1MSK1 0.808 0.325 -3 0.951
SRPK3SRPK3 0.803 0.307 -3 0.936
MSK2MSK2 0.803 0.295 -3 0.950
CDKL1CDKL1 0.803 0.313 -3 0.968
PAK1PAK1 0.802 0.275 -2 0.810
AURBAURB 0.802 0.275 -2 0.733
AKT2AKT2 0.801 0.336 -3 0.930
DYRK3DYRK3 0.801 0.357 1 0.808
DYRK2DYRK2 0.801 0.279 1 0.768
PIM2PIM2 0.801 0.362 -3 0.956
LATS2LATS2 0.800 0.184 -5 0.677
CAMK1BCAMK1B 0.800 0.321 -3 0.965
COTCOT 0.800 0.150 2 0.591
DYRK4DYRK4 0.798 0.285 1 0.670
SGK3SGK3 0.798 0.343 -3 0.946
WNK1WNK1 0.798 0.317 -2 0.849
PKACAPKACA 0.798 0.290 -2 0.714
CDKL5CDKL5 0.797 0.252 -3 0.970
PKN2PKN2 0.796 0.277 -3 0.944
MNK1MNK1 0.796 0.296 -2 0.830
CAMK1GCAMK1G 0.796 0.341 -3 0.963
HIPK1HIPK1 0.796 0.316 1 0.783
PKCDPKCD 0.795 0.238 2 0.489
HIPK2HIPK2 0.795 0.257 1 0.691
PKCGPKCG 0.795 0.274 2 0.474
PKN3PKN3 0.795 0.204 -3 0.955
SKMLCKSKMLCK 0.795 0.252 -2 0.859
PAK3PAK3 0.794 0.248 -2 0.802
MAPKAPK2MAPKAPK2 0.794 0.239 -3 0.924
CAMK2ACAMK2A 0.794 0.218 2 0.584
MAPKAPK3MAPKAPK3 0.794 0.258 -3 0.946
PRKD3PRKD3 0.794 0.298 -3 0.951
MYLK4MYLK4 0.793 0.298 -2 0.804
P70S6KP70S6K 0.793 0.330 -3 0.947
ICKICK 0.793 0.259 -3 0.967
PKG2PKG2 0.792 0.251 -2 0.761
PAK6PAK6 0.792 0.209 -2 0.737
NUAK2NUAK2 0.792 0.271 -3 0.958
CAMLCKCAMLCK 0.792 0.278 -2 0.860
PKCBPKCB 0.791 0.229 2 0.462
SGK1SGK1 0.790 0.344 -3 0.882
MNK2MNK2 0.789 0.244 -2 0.819
CDC7CDC7 0.789 0.050 1 0.801
PKCAPKCA 0.788 0.207 2 0.451
MTORMTOR 0.788 0.085 1 0.796
AKT1AKT1 0.787 0.303 -3 0.933
AKT3AKT3 0.787 0.318 -3 0.889
PRKD1PRKD1 0.787 0.147 -3 0.947
PAK2PAK2 0.787 0.224 -2 0.797
NIKNIK 0.787 0.312 -3 0.933
MST4MST4 0.787 0.163 2 0.540
CAMK4CAMK4 0.786 0.214 -3 0.944
DCAMKL1DCAMKL1 0.786 0.304 -3 0.937
DAPK2DAPK2 0.786 0.268 -3 0.960
CAMK2BCAMK2B 0.786 0.150 2 0.550
DYRK1BDYRK1B 0.785 0.249 1 0.701
AMPKA1AMPKA1 0.785 0.223 -3 0.948
PKCHPKCH 0.785 0.227 2 0.449
RAF1RAF1 0.785 0.145 1 0.812
PKCZPKCZ 0.785 0.233 2 0.481
AMPKA2AMPKA2 0.784 0.233 -3 0.948
GCN2GCN2 0.784 -0.007 2 0.529
HUNKHUNK 0.784 0.201 2 0.579
MELKMELK 0.784 0.241 -3 0.955
AURAAURA 0.783 0.163 -2 0.703
MOSMOS 0.783 0.074 1 0.853
CAMK2DCAMK2D 0.782 0.120 -3 0.954
NLKNLK 0.782 0.102 1 0.840
CAMK2GCAMK2G 0.782 0.021 2 0.553
CAMK1DCAMK1D 0.782 0.298 -3 0.922
DYRK1ADYRK1A 0.782 0.238 1 0.768
RIPK1RIPK1 0.782 0.241 1 0.866
PKCEPKCE 0.782 0.278 2 0.460
CDK10CDK10 0.782 0.213 1 0.665
LATS1LATS1 0.781 0.175 -3 0.920
RIPK3RIPK3 0.781 0.144 3 0.701
PAK4PAK4 0.781 0.210 -2 0.695
HIPK3HIPK3 0.780 0.261 1 0.772
MRCKBMRCKB 0.780 0.347 -3 0.946
BRSK1BRSK1 0.779 0.183 -3 0.956
PRPKPRPK 0.779 -0.059 -1 0.577
PKCTPKCT 0.779 0.246 2 0.440
PAK5PAK5 0.779 0.211 -2 0.686
TSSK1TSSK1 0.779 0.197 -3 0.948
CHAK2CHAK2 0.779 0.108 -1 0.710
CRIKCRIK 0.778 0.399 -3 0.927
MOKMOK 0.777 0.345 1 0.815
MRCKAMRCKA 0.777 0.324 -3 0.946
ROCK2ROCK2 0.777 0.373 -3 0.946
PKCIPKCI 0.777 0.253 2 0.463
PDHK4PDHK4 0.777 -0.072 1 0.844
WNK3WNK3 0.777 0.091 1 0.815
DCAMKL2DCAMKL2 0.777 0.230 -3 0.950
PHKG1PHKG1 0.777 0.163 -3 0.949
SMMLCKSMMLCK 0.776 0.303 -3 0.970
IKKBIKKB 0.776 -0.005 -2 0.693
DRAK1DRAK1 0.776 0.210 1 0.758
ATRATR 0.775 0.017 1 0.812
DSTYKDSTYK 0.775 0.008 2 0.609
ULK2ULK2 0.775 -0.039 2 0.482
IRE1IRE1 0.775 0.138 1 0.854
PASKPASK 0.774 0.280 -3 0.936
TGFBR2TGFBR2 0.774 0.029 -2 0.809
NIM1NIM1 0.774 0.086 3 0.747
SIKSIK 0.774 0.176 -3 0.944
MARK4MARK4 0.774 0.078 4 0.811
NUAK1NUAK1 0.773 0.167 -3 0.953
MAPKAPK5MAPKAPK5 0.772 0.191 -3 0.949
NEK6NEK6 0.772 -0.022 -2 0.825
BMPR2BMPR2 0.772 -0.052 -2 0.852
QIKQIK 0.772 0.164 -3 0.946
QSKQSK 0.772 0.146 4 0.782
DMPK1DMPK1 0.772 0.374 -3 0.939
TBK1TBK1 0.772 -0.051 1 0.712
TSSK2TSSK2 0.771 0.137 -5 0.660
HASPINHASPIN 0.771 0.478 -1 0.931
DAPK3DAPK3 0.771 0.296 -3 0.958
GRK5GRK5 0.771 -0.022 -3 0.814
PKRPKR 0.770 0.233 1 0.869
ROCK1ROCK1 0.770 0.366 -3 0.946
WNK4WNK4 0.770 0.265 -2 0.837
DAPK1DAPK1 0.769 0.288 -3 0.959
BRSK2BRSK2 0.769 0.121 -3 0.952
GRK6GRK6 0.768 0.029 1 0.806
MLK1MLK1 0.768 -0.014 2 0.529
CHK2CHK2 0.768 0.294 -3 0.898
GRK1GRK1 0.768 0.013 -2 0.770
CAMK1ACAMK1A 0.768 0.276 -3 0.898
CDK7CDK7 0.768 0.071 1 0.686
NEK7NEK7 0.767 -0.069 -3 0.817
DLKDLK 0.767 0.111 1 0.805
SNRKSNRK 0.767 0.103 2 0.435
IKKEIKKE 0.767 -0.065 1 0.701
MAKMAK 0.767 0.258 -2 0.741
IRE2IRE2 0.767 0.065 2 0.438
MARK3MARK3 0.767 0.135 4 0.735
MLK3MLK3 0.766 0.030 2 0.472
ULK1ULK1 0.766 -0.054 -3 0.785
PDHK1PDHK1 0.766 -0.158 1 0.815
ERK5ERK5 0.766 -0.017 1 0.753
PKN1PKN1 0.765 0.223 -3 0.952
PLK1PLK1 0.765 0.038 -2 0.787
TTBK2TTBK2 0.765 -0.011 2 0.444
KISKIS 0.765 0.047 1 0.703
PHKG2PHKG2 0.764 0.171 -3 0.944
CDK14CDK14 0.764 0.129 1 0.676
BCKDKBCKDK 0.764 -0.108 -1 0.530
CDK12CDK12 0.764 0.090 1 0.647
CDK9CDK9 0.763 0.077 1 0.676
MASTLMASTL 0.763 -0.077 -2 0.779
NEK2NEK2 0.763 0.068 2 0.501
FAM20CFAM20C 0.763 -0.026 2 0.413
ANKRD3ANKRD3 0.763 0.019 1 0.841
CDK13CDK13 0.762 0.054 1 0.671
ATMATM 0.762 -0.004 1 0.751
CHAK1CHAK1 0.762 0.076 2 0.462
CDK18CDK18 0.762 0.082 1 0.627
NEK9NEK9 0.762 -0.050 2 0.518
PKG1PKG1 0.762 0.228 -2 0.694
BUB1BUB1 0.761 0.275 -5 0.669
SBKSBK 0.761 0.263 -3 0.857
DNAPKDNAPK 0.761 0.045 1 0.690
BMPR1BBMPR1B 0.761 0.089 1 0.741
ALK4ALK4 0.760 0.036 -2 0.834
JNK2JNK2 0.760 0.097 1 0.637
PLK3PLK3 0.760 0.022 2 0.566
CDK8CDK8 0.760 0.021 1 0.670
CHK1CHK1 0.760 0.091 -3 0.910
CDK19CDK19 0.760 0.043 1 0.633
MARK1MARK1 0.760 0.113 4 0.758
MLK2MLK2 0.759 -0.039 2 0.507
GRK7GRK7 0.759 0.042 1 0.753
SSTKSSTK 0.759 0.179 4 0.769
CDK1CDK1 0.759 0.065 1 0.655
STK33STK33 0.759 0.153 2 0.423
GRK4GRK4 0.758 -0.084 -2 0.802
MLK4MLK4 0.758 0.001 2 0.460
IRAK4IRAK4 0.758 0.169 1 0.839
TGFBR1TGFBR1 0.758 0.027 -2 0.808
IKKAIKKA 0.756 -0.091 -2 0.676
JNK3JNK3 0.756 0.067 1 0.674
PERKPERK 0.755 0.037 -2 0.814
MST3MST3 0.755 0.139 2 0.564
ALK2ALK2 0.753 0.041 -2 0.818
MEK1MEK1 0.753 -0.026 2 0.561
MARK2MARK2 0.753 0.050 4 0.700
P38AP38A 0.753 0.068 1 0.703
VRK2VRK2 0.753 -0.024 1 0.876
PLK4PLK4 0.752 -0.004 2 0.402
CDK5CDK5 0.752 0.039 1 0.702
TLK2TLK2 0.752 -0.028 1 0.795
ERK2ERK2 0.752 0.057 1 0.697
YSK4YSK4 0.751 -0.035 1 0.749
CDK17CDK17 0.750 0.051 1 0.577
P38GP38G 0.750 0.061 1 0.568
PRP4PRP4 0.749 0.064 -3 0.741
LOKLOK 0.749 0.177 -2 0.763
ERK1ERK1 0.749 0.054 1 0.627
NEK5NEK5 0.748 0.068 1 0.826
ACVR2BACVR2B 0.747 -0.010 -2 0.792
HRIHRI 0.747 -0.034 -2 0.826
SMG1SMG1 0.747 -0.061 1 0.771
ERK7ERK7 0.747 0.025 2 0.375
MEK5MEK5 0.746 0.028 2 0.530
LKB1LKB1 0.746 0.129 -3 0.847
SLKSLK 0.746 0.116 -2 0.702
PINK1PINK1 0.746 -0.000 1 0.867
ACVR2AACVR2A 0.745 -0.026 -2 0.784
TLK1TLK1 0.745 0.022 -2 0.803
CDK4CDK4 0.745 0.098 1 0.638
TAO3TAO3 0.745 0.039 1 0.779
BRAFBRAF 0.745 -0.019 -4 0.762
CDK2CDK2 0.745 0.004 1 0.729
MPSK1MPSK1 0.744 0.061 1 0.815
P38BP38B 0.744 0.042 1 0.628
CDK3CDK3 0.744 0.045 1 0.592
PDK1PDK1 0.744 0.129 1 0.811
GAKGAK 0.744 0.139 1 0.816
LRRK2LRRK2 0.744 0.204 2 0.545
MEKK3MEKK3 0.744 0.018 1 0.784
GRK2GRK2 0.744 -0.018 -2 0.701
GSK3AGSK3A 0.743 0.066 4 0.538
NEK8NEK8 0.743 0.060 2 0.519
BMPR1ABMPR1A 0.743 0.049 1 0.715
GSK3BGSK3B 0.743 0.049 4 0.530
CDK16CDK16 0.742 0.055 1 0.599
MEKK1MEKK1 0.741 -0.061 1 0.790
HPK1HPK1 0.741 0.146 1 0.763
GCKGCK 0.740 0.121 1 0.770
ZAKZAK 0.739 -0.073 1 0.757
TTBK1TTBK1 0.738 -0.077 2 0.399
PBKPBK 0.738 0.127 1 0.718
CAMKK2CAMKK2 0.738 0.064 -2 0.699
TAO2TAO2 0.738 0.024 2 0.526
NEK11NEK11 0.738 0.033 1 0.779
CAMKK1CAMKK1 0.738 0.033 -2 0.695
CDK6CDK6 0.737 0.063 1 0.653
TNIKTNIK 0.736 0.083 3 0.813
KHS2KHS2 0.736 0.137 1 0.769
IRAK1IRAK1 0.736 -0.047 -1 0.609
MEKK2MEKK2 0.735 -0.058 2 0.499
P38DP38D 0.735 0.043 1 0.578
NEK4NEK4 0.734 0.039 1 0.787
YANK3YANK3 0.733 0.027 2 0.312
JNK1JNK1 0.732 0.043 1 0.630
KHS1KHS1 0.732 0.093 1 0.758
NEK1NEK1 0.732 0.063 1 0.813
MEKK6MEKK6 0.732 0.055 1 0.757
CK1ECK1E 0.731 -0.035 -3 0.463
CK2A2CK2A2 0.730 0.001 1 0.665
PLK2PLK2 0.730 -0.024 -3 0.699
TAK1TAK1 0.729 0.035 1 0.790
HGKHGK 0.729 0.009 3 0.808
PDHK3_TYRPDHK3_TYR 0.728 0.184 4 0.913
LIMK2_TYRLIMK2_TYR 0.728 0.263 -3 0.903
GRK3GRK3 0.728 -0.036 -2 0.668
VRK1VRK1 0.727 0.022 2 0.528
MAP3K15MAP3K15 0.725 -0.003 1 0.747
YSK1YSK1 0.725 0.036 2 0.497
EEF2KEEF2K 0.725 -0.024 3 0.762
MINKMINK 0.724 -0.010 1 0.763
CK1A2CK1A2 0.724 -0.027 -3 0.422
MST1MST1 0.724 0.003 1 0.758
CK2A1CK2A1 0.724 0.010 1 0.648
TESK1_TYRTESK1_TYR 0.723 0.166 3 0.845
PDHK4_TYRPDHK4_TYR 0.722 0.161 2 0.617
CK1DCK1D 0.721 -0.041 -3 0.413
NEK3NEK3 0.721 0.030 1 0.750
CK1G1CK1G1 0.720 -0.069 -3 0.451
MEK2MEK2 0.719 -0.085 2 0.500
MST2MST2 0.719 -0.094 1 0.765
MAP2K6_TYRMAP2K6_TYR 0.718 0.096 -1 0.580
RIPK2RIPK2 0.718 -0.101 1 0.719
PINK1_TYRPINK1_TYR 0.718 0.129 1 0.847
MAP2K4_TYRMAP2K4_TYR 0.717 0.041 -1 0.577
MYO3BMYO3B 0.717 0.073 2 0.500
MAP2K7_TYRMAP2K7_TYR 0.717 0.065 2 0.569
PKMYT1_TYRPKMYT1_TYR 0.716 0.058 3 0.821
BMPR2_TYRBMPR2_TYR 0.714 0.044 -1 0.571
OSR1OSR1 0.713 -0.013 2 0.506
LIMK1_TYRLIMK1_TYR 0.713 0.097 2 0.522
TNK2TNK2 0.712 0.144 3 0.734
TNK1TNK1 0.711 0.196 3 0.744
BIKEBIKE 0.710 0.032 1 0.697
PDHK1_TYRPDHK1_TYR 0.710 -0.016 -1 0.578
TAO1TAO1 0.710 0.002 1 0.719
TTKTTK 0.709 -0.010 -2 0.809
RETRET 0.709 0.021 1 0.799
EPHA6EPHA6 0.709 0.029 -1 0.532
DDR1DDR1 0.708 0.045 4 0.822
ALPHAK3ALPHAK3 0.705 -0.019 -1 0.514
ASK1ASK1 0.705 -0.039 1 0.740
MYO3AMYO3A 0.703 -0.023 1 0.814
MST1RMST1R 0.703 -0.038 3 0.785
EPHA4EPHA4 0.701 0.018 2 0.593
EPHB4EPHB4 0.701 -0.025 -1 0.503
NEK10_TYRNEK10_TYR 0.701 0.009 1 0.705
WEE1_TYRWEE1_TYR 0.700 0.046 -1 0.529
DDR2DDR2 0.700 0.104 3 0.698
FGFR2FGFR2 0.698 -0.037 3 0.768
TYRO3TYRO3 0.696 -0.099 3 0.754
ABL2ABL2 0.696 -0.023 -1 0.506
JAK3JAK3 0.695 -0.072 1 0.778
KDRKDR 0.694 -0.013 3 0.710
AAK1AAK1 0.694 0.043 1 0.591
TXKTXK 0.693 -0.001 1 0.755
SRMSSRMS 0.693 -0.026 1 0.776
ITKITK 0.693 -0.000 -1 0.492
YANK2YANK2 0.691 -0.016 2 0.316
AXLAXL 0.691 -0.066 3 0.747
CSF1RCSF1R 0.691 -0.115 3 0.751
ABL1ABL1 0.690 -0.056 -1 0.501
TYK2TYK2 0.690 -0.236 1 0.786
TEKTEK 0.690 -0.050 3 0.694
YES1YES1 0.689 -0.092 -1 0.518
FLT1FLT1 0.689 -0.025 -1 0.519
INSRRINSRR 0.689 -0.111 3 0.706
KITKIT 0.688 -0.067 3 0.758
ROS1ROS1 0.688 -0.197 3 0.715
EPHB1EPHB1 0.688 -0.081 1 0.760
EPHB3EPHB3 0.687 -0.077 -1 0.478
FGRFGR 0.687 -0.132 1 0.786
PDGFRBPDGFRB 0.687 -0.138 3 0.756
JAK2JAK2 0.687 -0.217 1 0.773
FLT3FLT3 0.687 -0.084 3 0.753
MERTKMERTK 0.686 -0.081 3 0.752
PTK2BPTK2B 0.686 0.000 -1 0.477
EPHA7EPHA7 0.686 -0.041 2 0.566
FGFR3FGFR3 0.686 -0.058 3 0.739
TNNI3K_TYRTNNI3K_TYR 0.686 -0.076 1 0.780
EPHB2EPHB2 0.685 -0.075 -1 0.469
METMET 0.685 -0.054 3 0.767
EPHA3EPHA3 0.685 -0.065 2 0.551
STLK3STLK3 0.685 -0.141 1 0.725
BMXBMX 0.685 -0.023 -1 0.433
FGFR1FGFR1 0.685 -0.130 3 0.730
FERFER 0.684 -0.179 1 0.790
TECTEC 0.684 -0.067 -1 0.446
EPHA1EPHA1 0.683 -0.059 3 0.742
CK1ACK1A 0.681 -0.076 -3 0.314
PTK2PTK2 0.681 0.013 -1 0.478
EPHA5EPHA5 0.681 -0.031 2 0.577
FLT4FLT4 0.681 -0.092 3 0.704
BLKBLK 0.680 -0.066 -1 0.490
MATKMATK 0.680 -0.051 -1 0.483
LCKLCK 0.680 -0.105 -1 0.487
PTK6PTK6 0.680 -0.189 -1 0.468
PDGFRAPDGFRA 0.677 -0.189 3 0.752
LTKLTK 0.677 -0.133 3 0.699
BTKBTK 0.676 -0.161 -1 0.476
HCKHCK 0.676 -0.192 -1 0.487
NTRK1NTRK1 0.675 -0.181 -1 0.498
FYNFYN 0.675 -0.069 -1 0.466
EPHA8EPHA8 0.674 -0.069 -1 0.470
ERBB2ERBB2 0.674 -0.128 1 0.736
JAK1JAK1 0.674 -0.183 1 0.726
ALKALK 0.673 -0.176 3 0.676
CSKCSK 0.671 -0.106 2 0.561
EPHA2EPHA2 0.670 -0.045 -1 0.445
FRKFRK 0.669 -0.126 -1 0.493
FGFR4FGFR4 0.668 -0.092 -1 0.465
CK1G3CK1G3 0.668 -0.059 -3 0.268
NTRK2NTRK2 0.667 -0.227 3 0.721
EGFREGFR 0.667 -0.101 1 0.648
INSRINSR 0.667 -0.193 3 0.694
NTRK3NTRK3 0.666 -0.178 -1 0.458
SYKSYK 0.665 -0.043 -1 0.447
SRCSRC 0.663 -0.122 -1 0.467
LYNLYN 0.663 -0.156 3 0.685
IGF1RIGF1R 0.655 -0.156 3 0.645
MUSKMUSK 0.655 -0.148 1 0.647
ERBB4ERBB4 0.654 -0.072 1 0.654
CK1G2CK1G2 0.653 -0.053 -3 0.367
ZAP70ZAP70 0.652 -0.021 -1 0.427
FESFES 0.641 -0.150 -1 0.422