Motif 316 (n=51)

Position-wise Probabilities
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uniprot genes site source protein function
A6NKT7 RGPD3 S1232 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O14715 RGPD8 S1231 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O60264 SMARCA5 S755 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}.
O75112 LDB3 S505 ochoa LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.
O75962 TRIO S2506 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
P09972 ALDOC S45 ochoa Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) None
P0DJD0 RGPD1 S1216 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1224 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P20290 BTF3 S30 ochoa Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.
P25685 DNAJB1 S149 psp DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}.
P26045 PTPN3 S425 ochoa Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P26639 TARS1 S110 ochoa Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}.
P28370 SMARCA1 S770 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1) [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
P29274 ADORA2A S329 ochoa Adenosine receptor A2a Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}.
P31323 PRKAR2B T69 ochoa cAMP-dependent protein kinase type II-beta regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P49792 RANBP2 S2207 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51617 IRAK1 S601 ochoa Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P84022 SMAD3 S309 psp Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}.
Q15149 PLEC S1181 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15149 PLEC S2958 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q5FWE3 PRRT3 S769 ochoa Proline-rich transmembrane protein 3 None
Q5TCZ1 SH3PXD2A S1041 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5VST9 OBSCN S6961 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q6NYC8 PPP1R18 S468 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6ZRV2 FAM83H S1096 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q7Z3J3 RGPD4 S1232 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q8NDX1 PSD4 S905 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8NHQ8 RASSF8 S385 ochoa Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) None
Q96JQ0 DCHS1 S2983 ochoa Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}.
Q96PK6 RBM14 S560 ochoa RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}.
Q96S21 RAB40C S256 ochoa Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}.
Q99569 PKP4 S341 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99666 RGPD5 S1231 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99959 PKP2 S329 ochoa Plakophilin-2 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}.
Q9BW71 HIRIP3 S500 ochoa HIRA-interacting protein 3 Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}.
Q9C0C2 TNKS1BP1 S1533 ochoa 182 kDa tankyrase-1-binding protein None
Q9P244 LRFN1 S716 ochoa Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}.
Q9P2Y5 UVRAG S522 ochoa|psp UV radiation resistance-associated gene protein (p63) Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}.
Q9UBL3 ASH2L S316 ochoa Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
Q9UPS6 SETD1B S1283 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9UPT8 ZC3H4 S1065 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9UQ35 SRRM2 S150 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y3Q8 TSC22D4 S233 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y4A5 TRRAP S2075 ochoa Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}.
Q15118 PDK1 S25 EPSD [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}.
O60566 BUB1B S694 Sugiyama Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.
P68431 H3C1 Y42 EPSD Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6P0Q8 MAST2 S1019 Sugiyama Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
P84243 H3-3A Y42 Sugiyama Histone H3.3 Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}.
Q16695 H3-4 Y42 Sugiyama Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q71DI3 H3C15 Y42 Sugiyama Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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reactome_id name p -log10_p
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 1.291229e-07 6.889
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 7.320523e-06 5.135
R-HSA-2299718 Condensation of Prophase Chromosomes 4.040787e-05 4.394
R-HSA-3214841 PKMTs methylate histone lysines 2.561932e-05 4.591
R-HSA-193704 p75 NTR receptor-mediated signalling 4.251638e-05 4.371
R-HSA-912446 Meiotic recombination 5.684702e-05 4.245
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 6.462238e-05 4.190
R-HSA-201681 TCF dependent signaling in response to WNT 7.391551e-05 4.131
R-HSA-68875 Mitotic Prophase 1.070764e-04 3.970
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 1.353515e-04 3.869
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 1.735642e-04 3.761
R-HSA-427413 NoRC negatively regulates rRNA expression 1.735642e-04 3.761
R-HSA-5578749 Transcriptional regulation by small RNAs 1.820519e-04 3.740
R-HSA-73728 RNA Polymerase I Promoter Opening 2.199404e-04 3.658
R-HSA-5334118 DNA methylation 2.611149e-04 3.583
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 2.611170e-04 3.583
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 3.376237e-04 3.472
R-HSA-1500620 Meiosis 3.215561e-04 3.493
R-HSA-73887 Death Receptor Signaling 3.376237e-04 3.472
R-HSA-162582 Signal Transduction 3.217232e-04 3.493
R-HSA-68616 Assembly of the ORC complex at the origin of replication 3.577270e-04 3.446
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 4.135952e-04 3.383
R-HSA-212300 PRC2 methylates histones and DNA 4.747837e-04 3.324
R-HSA-427359 SIRT1 negatively regulates rRNA expression 5.074367e-04 3.295
R-HSA-68886 M Phase 4.866985e-04 3.313
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 6.139295e-04 3.212
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 6.523529e-04 3.186
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 6.523529e-04 3.186
R-HSA-5619507 Activation of HOX genes during differentiation 7.336940e-04 3.134
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.336940e-04 3.134
R-HSA-9710421 Defective pyroptosis 7.767335e-04 3.110
R-HSA-8851680 Butyrophilin (BTN) family interactions 8.325973e-04 3.080
R-HSA-211000 Gene Silencing by RNA 8.063602e-04 3.093
R-HSA-195721 Signaling by WNT 8.266771e-04 3.083
R-HSA-212165 Epigenetic regulation of gene expression 1.218196e-03 2.914
R-HSA-73772 RNA Polymerase I Promoter Escape 1.237172e-03 2.908
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 1.463794e-03 2.835
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 1.463794e-03 2.835
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 1.463794e-03 2.835
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.352655e-03 2.869
R-HSA-209543 p75NTR recruits signalling complexes 1.467039e-03 2.834
R-HSA-193648 NRAGE signals death through JNK 1.486825e-03 2.828
R-HSA-8878171 Transcriptional regulation by RUNX1 1.663981e-03 2.779
R-HSA-1474165 Reproduction 1.704933e-03 2.768
R-HSA-3247509 Chromatin modifying enzymes 1.912226e-03 2.718
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 1.766006e-03 2.753
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 1.766006e-03 2.753
R-HSA-9616222 Transcriptional regulation of granulopoiesis 1.917048e-03 2.717
R-HSA-193639 p75NTR signals via NF-kB 2.054982e-03 2.687
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 2.054982e-03 2.687
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 2.600892e-03 2.585
R-HSA-4839726 Chromatin organization 2.449476e-03 2.611
R-HSA-388841 Regulation of T cell activation by CD28 family 2.734637e-03 2.563
R-HSA-9764560 Regulation of CDH1 Gene Transcription 2.600892e-03 2.585
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.891399e-03 2.539
R-HSA-73854 RNA Polymerase I Promoter Clearance 3.201154e-03 2.495
R-HSA-73864 RNA Polymerase I Transcription 3.418550e-03 2.466
R-HSA-416482 G alpha (12/13) signalling events 3.418550e-03 2.466
R-HSA-1640170 Cell Cycle 3.587076e-03 2.445
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 4.124267e-03 2.385
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 3.879996e-03 2.411
R-HSA-977225 Amyloid fiber formation 3.761268e-03 2.425
R-HSA-69278 Cell Cycle, Mitotic 4.142391e-03 2.383
R-HSA-9909648 Regulation of PD-L1(CD274) expression 4.451221e-03 2.352
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.701413e-03 2.328
R-HSA-9645723 Diseases of programmed cell death 4.775287e-03 2.321
R-HSA-3214842 HDMs demethylate histones 5.326498e-03 2.274
R-HSA-2559583 Cellular Senescence 5.139194e-03 2.289
R-HSA-68867 Assembly of the pre-replicative complex 5.634322e-03 2.249
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.194054e-03 2.284
R-HSA-1266695 Interleukin-7 signaling 5.326498e-03 2.274
R-HSA-3214847 HATs acetylate histones 6.746848e-03 2.171
R-HSA-389948 Co-inhibition by PD-1 7.163492e-03 2.145
R-HSA-9842860 Regulation of endogenous retroelements 7.260822e-03 2.139
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.260822e-03 2.139
R-HSA-2559580 Oxidative Stress Induced Senescence 7.260822e-03 2.139
R-HSA-69002 DNA Replication Pre-Initiation 8.742849e-03 2.058
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 1.037957e-02 1.984
R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 1.037957e-02 1.984
R-HSA-3304347 Loss of Function of SMAD4 in Cancer 1.037957e-02 1.984
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 9.541771e-03 2.020
R-HSA-9006931 Signaling by Nuclear Receptors 1.064148e-02 1.973
R-HSA-9705683 SARS-CoV-2-host interactions 1.094260e-02 1.961
R-HSA-1912422 Pre-NOTCH Expression and Processing 9.545605e-03 2.020
R-HSA-3371556 Cellular response to heat stress 1.173616e-02 1.930
R-HSA-73886 Chromosome Maintenance 1.173616e-02 1.930
R-HSA-9670095 Inhibition of DNA recombination at telomere 1.181742e-02 1.927
R-HSA-3371568 Attenuation phase 1.181742e-02 1.927
R-HSA-8939211 ESR-mediated signaling 1.233444e-02 1.909
R-HSA-157118 Signaling by NOTCH 1.282250e-02 1.892
R-HSA-3214858 RMTs methylate histone arginines 1.430659e-02 1.844
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 1.724042e-02 1.763
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 1.724042e-02 1.763
R-HSA-8941237 Invadopodia formation 1.724042e-02 1.763
R-HSA-417973 Adenosine P1 receptors 1.724042e-02 1.763
R-HSA-3371571 HSF1-dependent transactivation 1.813539e-02 1.741
R-HSA-9018519 Estrogen-dependent gene expression 1.635487e-02 1.786
R-HSA-74160 Gene expression (Transcription) 1.728021e-02 1.762
R-HSA-212436 Generic Transcription Pathway 1.831749e-02 1.737
R-HSA-446728 Cell junction organization 2.009654e-02 1.697
R-HSA-8953897 Cellular responses to stimuli 1.858200e-02 1.731
R-HSA-3214815 HDACs deacetylate histones 2.049636e-02 1.688
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 2.065330e-02 1.685
R-HSA-3656532 TGFBR1 KD Mutants in Cancer 2.065330e-02 1.685
R-HSA-69306 DNA Replication 2.186029e-02 1.660
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 2.297851e-02 1.639
R-HSA-9610379 HCMV Late Events 2.320529e-02 1.634
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 2.405455e-02 1.619
R-HSA-165158 Activation of AKT2 2.405455e-02 1.619
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 2.405455e-02 1.619
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 2.744419e-02 1.562
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 2.744419e-02 1.562
R-HSA-187024 NGF-independant TRKA activation 2.744419e-02 1.562
R-HSA-5693606 DNA Double Strand Break Response 2.829173e-02 1.548
R-HSA-446107 Type I hemidesmosome assembly 3.754389e-02 1.425
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 3.082227e-02 1.511
R-HSA-68877 Mitotic Prometaphase 3.773918e-02 1.423
R-HSA-187015 Activation of TRKA receptors 3.418882e-02 1.466
R-HSA-444257 RSK activation 3.754389e-02 1.425
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 3.785538e-02 1.422
R-HSA-73857 RNA Polymerase II Transcription 3.233999e-02 1.490
R-HSA-1500931 Cell-Cell communication 2.950694e-02 1.530
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 2.941545e-02 1.531
R-HSA-9764265 Regulation of CDH1 Expression and Function 2.941545e-02 1.531
R-HSA-9678108 SARS-CoV-1 Infection 3.019851e-02 1.520
R-HSA-9609690 HCMV Early Events 3.908161e-02 1.408
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 3.908161e-02 1.408
R-HSA-9694516 SARS-CoV-2 Infection 3.949867e-02 1.403
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 4.088751e-02 1.388
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 4.088751e-02 1.388
R-HSA-5687128 MAPK6/MAPK4 signaling 4.181957e-02 1.379
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 4.263049e-02 1.370
R-HSA-141424 Amplification of signal from the kinetochores 4.263049e-02 1.370
R-HSA-438064 Post NMDA receptor activation events 4.427003e-02 1.354
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 5.414828e-02 1.266
R-HSA-937039 IRAK1 recruits IKK complex 5.414828e-02 1.266
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 7.047124e-02 1.152
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 8.651745e-02 1.063
R-HSA-171306 Packaging Of Telomere Ends 1.085260e-01 0.964
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.177980e-01 0.929
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.208676e-01 0.918
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.208676e-01 0.918
R-HSA-1855170 IPs transport between nucleus and cytosol 1.269753e-01 0.896
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.269753e-01 0.896
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.300135e-01 0.886
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 1.360588e-01 0.866
R-HSA-9823730 Formation of definitive endoderm 8.333013e-02 1.079
R-HSA-69618 Mitotic Spindle Checkpoint 5.728155e-02 1.242
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 1.239266e-01 0.907
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 7.047124e-02 1.152
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 7.047124e-02 1.152
R-HSA-9754189 Germ layer formation at gastrulation 8.013188e-02 1.096
R-HSA-209560 NF-kB is activated and signals survival 5.085007e-02 1.294
R-HSA-9796292 Formation of axial mesoderm 5.743524e-02 1.241
R-HSA-8849932 Synaptic adhesion-like molecules 7.692267e-02 1.114
R-HSA-163615 PKA activation 7.692267e-02 1.114
R-HSA-164378 PKA activation in glucagon signalling 7.692267e-02 1.114
R-HSA-418885 DCC mediated attractive signaling 6.397553e-02 1.194
R-HSA-1181150 Signaling by NODAL 8.333013e-02 1.079
R-HSA-1502540 Signaling by Activin 6.397553e-02 1.194
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 6.397553e-02 1.194
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 1.300135e-01 0.886
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 5.743524e-02 1.241
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 8.651745e-02 1.063
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 9.915826e-02 1.004
R-HSA-389357 CD28 dependent PI3K/Akt signaling 1.085260e-01 0.964
R-HSA-6809371 Formation of the cornified envelope 8.350435e-02 1.078
R-HSA-9609646 HCMV Infection 6.786625e-02 1.168
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 8.043290e-02 1.095
R-HSA-5693532 DNA Double-Strand Break Repair 1.194331e-01 0.923
R-HSA-111931 PKA-mediated phosphorylation of CREB 8.651745e-02 1.063
R-HSA-9008059 Interleukin-37 signaling 1.177980e-01 0.929
R-HSA-180746 Nuclear import of Rev protein 1.330413e-01 0.876
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 8.969389e-02 1.047
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 9.285948e-02 1.032
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 9.601426e-02 1.018
R-HSA-429947 Deadenylation of mRNA 9.915826e-02 1.004
R-HSA-446652 Interleukin-1 family signaling 1.182933e-01 0.927
R-HSA-2467813 Separation of Sister Chromatids 1.321489e-01 0.879
R-HSA-9754560 SARS-CoV-2 modulates autophagy 4.754056e-02 1.323
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 8.969389e-02 1.047
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 1.239266e-01 0.907
R-HSA-9930044 Nuclear RNA decay 1.269753e-01 0.896
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 6.660464e-02 1.176
R-HSA-9675151 Disorders of Developmental Biology 7.047124e-02 1.152
R-HSA-180024 DARPP-32 events 1.147179e-01 0.940
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 1.147179e-01 0.940
R-HSA-163359 Glucagon signaling in metabolic regulation 1.300135e-01 0.886
R-HSA-157579 Telomere Maintenance 5.458228e-02 1.263
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1.269753e-01 0.896
R-HSA-3371511 HSF1 activation 1.390659e-01 0.857
R-HSA-70171 Glycolysis 5.728155e-02 1.242
R-HSA-69620 Cell Cycle Checkpoints 7.268292e-02 1.139
R-HSA-9839394 TGFBR3 expression 1.022915e-01 0.990
R-HSA-114604 GPVI-mediated activation cascade 1.390659e-01 0.857
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 8.651745e-02 1.063
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 9.601426e-02 1.018
R-HSA-70326 Glucose metabolism 7.639518e-02 1.117
R-HSA-111933 Calmodulin induced events 1.390659e-01 0.857
R-HSA-5218921 VEGFR2 mediated cell proliferation 1.022915e-01 0.990
R-HSA-111997 CaM pathway 1.390659e-01 0.857
R-HSA-9860931 Response of endothelial cells to shear stress 6.095194e-02 1.215
R-HSA-1280218 Adaptive Immune System 7.576156e-02 1.121
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 9.285948e-02 1.032
R-HSA-9006925 Intracellular signaling by second messengers 1.316093e-01 0.881
R-HSA-418038 Nucleotide-like (purinergic) receptors 7.692267e-02 1.114
R-HSA-397795 G-protein beta:gamma signalling 1.269753e-01 0.896
R-HSA-9855142 Cellular responses to mechanical stimuli 7.144413e-02 1.146
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.070569e-01 0.970
R-HSA-9692914 SARS-CoV-1-host interactions 6.375668e-02 1.195
R-HSA-5683057 MAPK family signaling cascades 1.355408e-01 0.868
R-HSA-168638 NOD1/2 Signaling Pathway 1.330413e-01 0.876
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 1.330413e-01 0.876
R-HSA-388396 GPCR downstream signalling 5.727899e-02 1.242
R-HSA-182971 EGFR downregulation 1.208676e-01 0.918
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 5.910670e-02 1.228
R-HSA-354192 Integrin signaling 1.269753e-01 0.896
R-HSA-9824446 Viral Infection Pathways 1.020780e-01 0.991
R-HSA-2262752 Cellular responses to stress 6.773236e-02 1.169
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 7.692267e-02 1.114
R-HSA-6804757 Regulation of TP53 Degradation 1.390659e-01 0.857
R-HSA-8941326 RUNX2 regulates bone development 1.390659e-01 0.857
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 9.285948e-02 1.032
R-HSA-9679506 SARS-CoV Infections 4.964296e-02 1.304
R-HSA-111465 Apoptotic cleavage of cellular proteins 1.239266e-01 0.907
R-HSA-8986944 Transcriptional Regulation by MECP2 4.761850e-02 1.322
R-HSA-372790 Signaling by GPCR 8.365487e-02 1.078
R-HSA-418990 Adherens junctions interactions 5.017117e-02 1.300
R-HSA-421270 Cell-cell junction organization 6.845999e-02 1.165
R-HSA-1266738 Developmental Biology 1.400864e-01 0.854
R-HSA-418555 G alpha (s) signalling events 1.415863e-01 0.849
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.420628e-01 0.848
R-HSA-180910 Vpr-mediated nuclear import of PICs 1.420628e-01 0.848
R-HSA-110331 Cleavage of the damaged purine 1.420628e-01 0.848
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 1.420628e-01 0.848
R-HSA-5689880 Ub-specific processing proteases 1.439684e-01 0.842
R-HSA-73927 Depurination 1.450494e-01 0.838
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.450494e-01 0.838
R-HSA-109582 Hemostasis 1.473625e-01 0.832
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 1.480259e-01 0.830
R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.480259e-01 0.830
R-HSA-6806003 Regulation of TP53 Expression and Degradation 1.480259e-01 0.830
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 1.509921e-01 0.821
R-HSA-177243 Interactions of Rev with host cellular proteins 1.509921e-01 0.821
R-HSA-176033 Interactions of Vpr with host cellular proteins 1.509921e-01 0.821
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 1.539482e-01 0.813
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.539482e-01 0.813
R-HSA-5218920 VEGFR2 mediated vascular permeability 1.539482e-01 0.813
R-HSA-5675221 Negative regulation of MAPK pathway 1.568942e-01 0.804
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 1.568942e-01 0.804
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 1.598301e-01 0.796
R-HSA-111996 Ca-dependent events 1.598301e-01 0.796
R-HSA-110329 Cleavage of the damaged pyrimidine 1.598301e-01 0.796
R-HSA-73928 Depyrimidination 1.598301e-01 0.796
R-HSA-379716 Cytosolic tRNA aminoacylation 1.598301e-01 0.796
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 1.627560e-01 0.788
R-HSA-373752 Netrin-1 signaling 1.656718e-01 0.781
R-HSA-3928662 EPHB-mediated forward signaling 1.656718e-01 0.781
R-HSA-5683826 Surfactant metabolism 1.656718e-01 0.781
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.685777e-01 0.773
R-HSA-774815 Nucleosome assembly 1.685777e-01 0.773
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 1.685777e-01 0.773
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 1.685777e-01 0.773
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.685777e-01 0.773
R-HSA-1489509 DAG and IP3 signaling 1.685777e-01 0.773
R-HSA-76009 Platelet Aggregation (Plug Formation) 1.685777e-01 0.773
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.714737e-01 0.766
R-HSA-9861718 Regulation of pyruvate metabolism 1.714737e-01 0.766
R-HSA-9839373 Signaling by TGFBR3 1.714737e-01 0.766
R-HSA-75153 Apoptotic execution phase 1.714737e-01 0.766
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 1.743597e-01 0.759
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 1.772359e-01 0.751
R-HSA-9634597 GPER1 signaling 1.772359e-01 0.751
R-HSA-389356 Co-stimulation by CD28 1.772359e-01 0.751
R-HSA-70263 Gluconeogenesis 1.772359e-01 0.751
R-HSA-109704 PI3K Cascade 1.829587e-01 0.738
R-HSA-6805567 Keratinization 1.856118e-01 0.731
R-HSA-449147 Signaling by Interleukins 1.867271e-01 0.729
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.886425e-01 0.724
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.914698e-01 0.718
R-HSA-1221632 Meiotic synapsis 1.914698e-01 0.718
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 1.931420e-01 0.714
R-HSA-73929 Base-Excision Repair, AP Site Formation 1.942874e-01 0.712
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.970953e-01 0.705
R-HSA-68882 Mitotic Anaphase 1.981853e-01 0.703
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.994489e-01 0.700
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1.998937e-01 0.699
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.998937e-01 0.699
R-HSA-177929 Signaling by EGFR 1.998937e-01 0.699
R-HSA-112399 IRS-mediated signalling 2.026825e-01 0.693
R-HSA-2980766 Nuclear Envelope Breakdown 2.026825e-01 0.693
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 2.026825e-01 0.693
R-HSA-9772572 Early SARS-CoV-2 Infection Events 2.054617e-01 0.687
R-HSA-194441 Metabolism of non-coding RNA 2.082314e-01 0.681
R-HSA-191859 snRNP Assembly 2.082314e-01 0.681
R-HSA-429914 Deadenylation-dependent mRNA decay 2.082314e-01 0.681
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 2.082314e-01 0.681
R-HSA-8873719 RAB geranylgeranylation 2.109917e-01 0.676
R-HSA-5362517 Signaling by Retinoic Acid 2.109917e-01 0.676
R-HSA-379724 tRNA Aminoacylation 2.109917e-01 0.676
R-HSA-168325 Viral Messenger RNA Synthesis 2.137424e-01 0.670
R-HSA-2428928 IRS-related events triggered by IGF1R 2.137424e-01 0.670
R-HSA-445717 Aquaporin-mediated transport 2.137424e-01 0.670
R-HSA-450294 MAP kinase activation 2.137424e-01 0.670
R-HSA-112043 PLC beta mediated events 2.137424e-01 0.670
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.164838e-01 0.665
R-HSA-6784531 tRNA processing in the nucleus 2.164838e-01 0.665
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 2.164838e-01 0.665
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.192158e-01 0.659
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.192158e-01 0.659
R-HSA-2428924 IGF1R signaling cascade 2.219384e-01 0.654
R-HSA-74751 Insulin receptor signalling cascade 2.219384e-01 0.654
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 2.219384e-01 0.654
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2.246517e-01 0.648
R-HSA-8854518 AURKA Activation by TPX2 2.273557e-01 0.643
R-HSA-112040 G-protein mediated events 2.300504e-01 0.638
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.327359e-01 0.633
R-HSA-448424 Interleukin-17 signaling 2.380794e-01 0.623
R-HSA-453276 Regulation of mitotic cell cycle 2.407374e-01 0.618
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 2.407374e-01 0.618
R-HSA-5663205 Infectious disease 2.412659e-01 0.618
R-HSA-112316 Neuronal System 2.416696e-01 0.617
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 2.460261e-01 0.609
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.460261e-01 0.609
R-HSA-5688426 Deubiquitination 2.480377e-01 0.605
R-HSA-69473 G2/M DNA damage checkpoint 2.486568e-01 0.604
R-HSA-9013694 Signaling by NOTCH4 2.486568e-01 0.604
R-HSA-380287 Centrosome maturation 2.512786e-01 0.600
R-HSA-1169408 ISG15 antiviral mechanism 2.512786e-01 0.600
R-HSA-416476 G alpha (q) signalling events 2.596445e-01 0.586
R-HSA-5693607 Processing of DNA double-strand break ends 2.668215e-01 0.574
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.693809e-01 0.570
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.744736e-01 0.561
R-HSA-6794362 Protein-protein interactions at synapses 2.770068e-01 0.558
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.790086e-01 0.554
R-HSA-70268 Pyruvate metabolism 2.845546e-01 0.546
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 2.859181e-01 0.544
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.870532e-01 0.542
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.920249e-01 0.535
R-HSA-202424 Downstream TCR signaling 2.920249e-01 0.535
R-HSA-73884 Base Excision Repair 2.920249e-01 0.535
R-HSA-74752 Signaling by Insulin receptor 2.994186e-01 0.524
R-HSA-2682334 EPH-Ephrin signaling 2.994186e-01 0.524
R-HSA-1257604 PIP3 activates AKT signaling 2.996398e-01 0.523
R-HSA-9837999 Mitochondrial protein degradation 3.043055e-01 0.517
R-HSA-1474290 Collagen formation 3.043055e-01 0.517
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 3.115732e-01 0.506
R-HSA-5607764 CLEC7A (Dectin-1) signaling 3.115732e-01 0.506
R-HSA-170834 Signaling by TGF-beta Receptor Complex 3.139792e-01 0.503
R-HSA-8878159 Transcriptional regulation by RUNX3 3.139792e-01 0.503
R-HSA-975871 MyD88 cascade initiated on plasma membrane 3.163769e-01 0.500
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 3.163769e-01 0.500
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 3.163769e-01 0.500
R-HSA-422356 Regulation of insulin secretion 3.163769e-01 0.500
R-HSA-9614085 FOXO-mediated transcription 3.187664e-01 0.497
R-HSA-5610787 Hedgehog 'off' state 3.211476e-01 0.493
R-HSA-9020702 Interleukin-1 signaling 3.235207e-01 0.490
R-HSA-9009391 Extra-nuclear estrogen signaling 3.235207e-01 0.490
R-HSA-111885 Opioid Signalling 3.305912e-01 0.481
R-HSA-1280215 Cytokine Signaling in Immune system 3.322861e-01 0.478
R-HSA-392499 Metabolism of proteins 3.342528e-01 0.476
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 3.352645e-01 0.475
R-HSA-112315 Transmission across Chemical Synapses 3.355197e-01 0.474
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 3.399057e-01 0.469
R-HSA-9700206 Signaling by ALK in cancer 3.399057e-01 0.469
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 3.422144e-01 0.466
R-HSA-975155 MyD88 dependent cascade initiated on endosome 3.445151e-01 0.463
R-HSA-1474244 Extracellular matrix organization 3.456883e-01 0.461
R-HSA-202403 TCR signaling 3.468080e-01 0.460
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3.468080e-01 0.460
R-HSA-166166 MyD88-independent TLR4 cascade 3.468080e-01 0.460
R-HSA-8953854 Metabolism of RNA 3.473789e-01 0.459
R-HSA-1483249 Inositol phosphate metabolism 3.513700e-01 0.454
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 3.536393e-01 0.451
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 3.559008e-01 0.449
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 3.604005e-01 0.443
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.626387e-01 0.441
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.693074e-01 0.433
R-HSA-5693538 Homology Directed Repair 3.693074e-01 0.433
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 3.715150e-01 0.430
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 3.715150e-01 0.430
R-HSA-8878166 Transcriptional regulation by RUNX2 3.715150e-01 0.430
R-HSA-168256 Immune System 3.771375e-01 0.424
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 3.780925e-01 0.422
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 3.780925e-01 0.422
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.796552e-01 0.421
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.802699e-01 0.420
R-HSA-73894 DNA Repair 3.821197e-01 0.418
R-HSA-162909 Host Interactions of HIV factors 3.824398e-01 0.417
R-HSA-194138 Signaling by VEGF 3.867573e-01 0.413
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 3.889050e-01 0.410
R-HSA-69481 G2/M Checkpoints 3.910452e-01 0.408
R-HSA-187037 Signaling by NTRK1 (TRKA) 3.931781e-01 0.405
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.974218e-01 0.401
R-HSA-163685 Integration of energy metabolism 4.141073e-01 0.383
R-HSA-5358351 Signaling by Hedgehog 4.182072e-01 0.379
R-HSA-1632852 Macroautophagy 4.243044e-01 0.372
R-HSA-162599 Late Phase of HIV Life Cycle 4.283342e-01 0.368
R-HSA-2871837 FCERI mediated NF-kB activation 4.323364e-01 0.364
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 4.402583e-01 0.356
R-HSA-166520 Signaling by NTRKs 4.402583e-01 0.356
R-HSA-9758941 Gastrulation 4.422217e-01 0.354
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.519380e-01 0.345
R-HSA-168273 Influenza Viral RNA Transcription and Replication 4.538612e-01 0.343
R-HSA-9612973 Autophagy 4.557778e-01 0.341
R-HSA-162587 HIV Life Cycle 4.576877e-01 0.339
R-HSA-9006936 Signaling by TGFB family members 4.633782e-01 0.334
R-HSA-5633007 Regulation of TP53 Activity 4.633782e-01 0.334
R-HSA-109581 Apoptosis 4.671393e-01 0.331
R-HSA-5619102 SLC transporter disorders 4.764290e-01 0.322
R-HSA-72306 tRNA processing 4.837460e-01 0.315
R-HSA-5621481 C-type lectin receptors (CLRs) 4.855595e-01 0.314
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 4.891678e-01 0.311
R-HSA-9664433 Leishmania parasite growth and survival 4.891678e-01 0.311
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 4.958682e-01 0.305
R-HSA-168255 Influenza Infection 4.998442e-01 0.301
R-HSA-3700989 Transcriptional Regulation by TP53 5.069776e-01 0.295
R-HSA-69275 G2/M Transition 5.120232e-01 0.291
R-HSA-453274 Mitotic G2-G2/M phases 5.154491e-01 0.288
R-HSA-5617833 Cilium Assembly 5.188513e-01 0.285
R-HSA-168898 Toll-like Receptor Cascades 5.205437e-01 0.284
R-HSA-72163 mRNA Splicing - Major Pathway 5.255856e-01 0.279
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 5.404011e-01 0.267
R-HSA-72172 mRNA Splicing 5.436312e-01 0.265
R-HSA-1643685 Disease 5.441800e-01 0.264
R-HSA-5357801 Programmed Cell Death 5.452379e-01 0.263
R-HSA-162906 HIV Infection 5.792121e-01 0.237
R-HSA-422475 Axon guidance 5.901176e-01 0.229
R-HSA-5619115 Disorders of transmembrane transporters 6.079268e-01 0.216
R-HSA-9675108 Nervous system development 6.250029e-01 0.204
R-HSA-76002 Platelet activation, signaling and aggregation 6.436589e-01 0.191
R-HSA-9658195 Leishmania infection 6.523880e-01 0.185
R-HSA-9824443 Parasitic Infection Pathways 6.523880e-01 0.185
R-HSA-5673001 RAF/MAP kinase cascade 6.621071e-01 0.179
R-HSA-5684996 MAPK1/MAPK3 signaling 6.703920e-01 0.174
R-HSA-1852241 Organelle biogenesis and maintenance 6.973110e-01 0.157
R-HSA-1428517 Aerobic respiration and respiratory electron transport 7.190853e-01 0.143
R-HSA-913531 Interferon Signaling 7.589812e-01 0.120
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 7.682583e-01 0.114
R-HSA-418594 G alpha (i) signalling events 7.787708e-01 0.109
R-HSA-72766 Translation 7.955042e-01 0.099
R-HSA-6798695 Neutrophil degranulation 8.150131e-01 0.089
R-HSA-597592 Post-translational protein modification 8.489841e-01 0.071
R-HSA-168249 Innate Immune System 8.588375e-01 0.066
R-HSA-500792 GPCR ligand binding 8.849706e-01 0.053
R-HSA-382551 Transport of small molecules 9.726133e-01 0.012
R-HSA-1430728 Metabolism 9.996824e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
AURCAURC 0.687 0.147 -2 0.595
WNK1WNK1 0.684 0.161 -2 0.785
CDC7CDC7 0.678 0.087 1 0.684
SKMLCKSKMLCK 0.677 0.166 -2 0.731
PRKD2PRKD2 0.677 0.061 -3 0.532
CLK3CLK3 0.676 0.095 1 0.584
HIPK4HIPK4 0.676 0.081 1 0.607
MOSMOS 0.676 0.147 1 0.731
PRKD1PRKD1 0.675 0.110 -3 0.595
MNK2MNK2 0.675 0.122 -2 0.706
PIM3PIM3 0.675 0.057 -3 0.551
COTCOT 0.674 0.051 2 0.704
SRPK1SRPK1 0.673 0.055 -3 0.476
MST4MST4 0.673 0.069 2 0.721
CHAK2CHAK2 0.672 0.094 -1 0.694
MARK4MARK4 0.672 0.112 4 0.723
NEK6NEK6 0.671 0.087 -2 0.614
NLKNLK 0.671 0.044 1 0.587
CDK18CDK18 0.671 0.085 1 0.449
RSK2RSK2 0.671 0.036 -3 0.499
RIPK3RIPK3 0.671 0.068 3 0.644
CDKL5CDKL5 0.670 0.029 -3 0.506
NUAK2NUAK2 0.670 0.047 -3 0.563
RSK3RSK3 0.669 0.048 -3 0.485
AMPKA1AMPKA1 0.669 0.080 -3 0.578
ERK5ERK5 0.669 0.044 1 0.565
MTORMTOR 0.669 -0.007 1 0.540
TSSK1TSSK1 0.668 0.103 -3 0.602
PIM1PIM1 0.668 0.037 -3 0.493
NDR1NDR1 0.668 0.038 -3 0.556
ATRATR 0.668 0.031 1 0.643
PRPKPRPK 0.667 0.039 -1 0.672
NDR2NDR2 0.667 0.044 -3 0.590
AURBAURB 0.667 0.092 -2 0.596
RAF1RAF1 0.666 -0.026 1 0.569
TSSK2TSSK2 0.666 0.095 -5 0.729
PAK6PAK6 0.665 0.073 -2 0.677
MNK1MNK1 0.665 0.081 -2 0.676
PAK1PAK1 0.665 0.076 -2 0.704
CDK7CDK7 0.665 0.048 1 0.487
CAMK1BCAMK1B 0.665 0.007 -3 0.563
P90RSKP90RSK 0.665 0.025 -3 0.502
PKACBPKACB 0.665 0.077 -2 0.607
PAK3PAK3 0.665 0.071 -2 0.705
CAMLCKCAMLCK 0.665 0.069 -2 0.701
PKN2PKN2 0.665 0.036 -3 0.547
AMPKA2AMPKA2 0.664 0.053 -3 0.549
PKACGPKACG 0.664 0.039 -2 0.640
SMG1SMG1 0.664 0.081 1 0.625
IRE1IRE1 0.664 0.060 1 0.601
MAPKAPK3MAPKAPK3 0.664 0.015 -3 0.519
PDHK4PDHK4 0.664 -0.088 1 0.609
CDKL1CDKL1 0.663 0.002 -3 0.506
KISKIS 0.663 0.013 1 0.487
DAPK2DAPK2 0.663 0.075 -3 0.579
DYRK2DYRK2 0.663 0.047 1 0.530
PRKD3PRKD3 0.662 0.029 -3 0.498
NIKNIK 0.662 0.042 -3 0.584
MLK2MLK2 0.662 0.070 2 0.682
ULK2ULK2 0.662 -0.013 2 0.631
PKCZPKCZ 0.662 0.085 2 0.654
PKCDPKCD 0.661 0.053 2 0.659
PKG2PKG2 0.661 0.071 -2 0.602
QIKQIK 0.661 0.031 -3 0.560
PKCBPKCB 0.661 0.072 2 0.633
ICKICK 0.661 0.026 -3 0.565
IKKBIKKB 0.661 -0.072 -2 0.566
PKCAPKCA 0.660 0.069 2 0.622
CLK2CLK2 0.660 0.091 -3 0.464
RIPK1RIPK1 0.660 0.022 1 0.588
NEK2NEK2 0.659 0.066 2 0.681
CLK4CLK4 0.659 0.051 -3 0.483
PDHK1PDHK1 0.659 -0.064 1 0.572
WNK3WNK3 0.659 -0.021 1 0.572
NIM1NIM1 0.659 0.027 3 0.619
NEK7NEK7 0.659 -0.026 -3 0.628
QSKQSK 0.659 0.051 4 0.698
MYLK4MYLK4 0.658 0.049 -2 0.664
HIPK1HIPK1 0.658 0.053 1 0.542
GCN2GCN2 0.658 -0.098 2 0.640
HIPK2HIPK2 0.658 0.045 1 0.474
CLK1CLK1 0.658 0.049 -3 0.480
PRKXPRKX 0.658 0.059 -3 0.440
MELKMELK 0.658 0.020 -3 0.530
NEK9NEK9 0.657 0.010 2 0.686
PKN3PKN3 0.657 -0.009 -3 0.538
SSTKSSTK 0.657 0.103 4 0.701
BMPR2BMPR2 0.657 -0.055 -2 0.624
BUB1BUB1 0.657 0.196 -5 0.656
MLK1MLK1 0.657 -0.034 2 0.676
DSTYKDSTYK 0.656 -0.053 2 0.728
TBK1TBK1 0.656 -0.062 1 0.466
CDK13CDK13 0.656 0.027 1 0.471
WNK4WNK4 0.656 0.114 -2 0.801
CDK19CDK19 0.656 0.018 1 0.426
P70S6KBP70S6KB 0.656 -0.006 -3 0.498
PIM2PIM2 0.656 0.029 -3 0.464
MLK3MLK3 0.656 0.021 2 0.629
PKCGPKCG 0.655 0.049 2 0.618
CDK14CDK14 0.655 0.050 1 0.474
AKT2AKT2 0.655 0.025 -3 0.424
HIPK3HIPK3 0.655 0.040 1 0.525
SGK3SGK3 0.655 0.045 -3 0.489
CAMK2DCAMK2D 0.654 -0.012 -3 0.565
CDK5CDK5 0.654 0.044 1 0.508
P38AP38A 0.654 0.043 1 0.494
PKCIPKCI 0.654 0.064 2 0.631
MARK3MARK3 0.654 0.058 4 0.671
CDK8CDK8 0.654 -0.001 1 0.456
HUNKHUNK 0.654 0.015 2 0.624
MAPKAPK2MAPKAPK2 0.654 -0.004 -3 0.471
PKRPKR 0.653 0.088 1 0.625
MPSK1MPSK1 0.653 0.126 1 0.635
MASTLMASTL 0.653 -0.045 -2 0.655
IKKEIKKE 0.652 -0.076 1 0.458
ERK1ERK1 0.652 0.030 1 0.431
CDK17CDK17 0.652 0.032 1 0.399
CDK9CDK9 0.652 0.019 1 0.469
CDK12CDK12 0.652 0.031 1 0.442
MSK2MSK2 0.652 0.001 -3 0.470
CAMK2GCAMK2G 0.651 -0.079 2 0.617
GRK5GRK5 0.651 -0.100 -3 0.552
PAK2PAK2 0.651 0.020 -2 0.696
P38BP38B 0.651 0.039 1 0.440
CDK10CDK10 0.651 0.033 1 0.466
CDK3CDK3 0.651 0.058 1 0.421
CAMK4CAMK4 0.651 -0.043 -3 0.534
CDK1CDK1 0.651 0.028 1 0.452
DCAMKL1DCAMKL1 0.650 0.049 -3 0.528
PHKG1PHKG1 0.650 -0.020 -3 0.547
NUAK1NUAK1 0.650 -0.016 -3 0.511
CHAK1CHAK1 0.650 0.014 2 0.653
DYRK3DYRK3 0.650 0.040 1 0.553
BCKDKBCKDK 0.650 -0.081 -1 0.643
MSK1MSK1 0.650 0.028 -3 0.462
JNK2JNK2 0.649 0.040 1 0.423
MARK2MARK2 0.649 0.051 4 0.664
PKCHPKCH 0.649 0.022 2 0.604
SIKSIK 0.649 -0.009 -3 0.482
SRPK2SRPK2 0.649 -0.013 -3 0.393
PKACAPKACA 0.649 0.045 -2 0.571
LATS2LATS2 0.649 -0.006 -5 0.596
ANKRD3ANKRD3 0.649 -0.024 1 0.591
BRSK2BRSK2 0.648 0.012 -3 0.541
MAKMAK 0.648 0.078 -2 0.633
ULK1ULK1 0.648 -0.083 -3 0.586
DYRK4DYRK4 0.648 0.052 1 0.464
CDK16CDK16 0.648 0.044 1 0.429
RSK4RSK4 0.648 0.010 -3 0.486
IRAK4IRAK4 0.648 0.067 1 0.586
CHK1CHK1 0.648 0.027 -3 0.553
IRE2IRE2 0.646 -0.002 2 0.594
MEK1MEK1 0.646 -0.003 2 0.688
P38DP38D 0.646 0.039 1 0.426
DYRK1ADYRK1A 0.645 0.006 1 0.531
VRK2VRK2 0.645 0.080 1 0.633
PKCTPKCT 0.645 0.037 2 0.611
MST3MST3 0.645 0.057 2 0.712
DNAPKDNAPK 0.645 0.030 1 0.522
BRSK1BRSK1 0.645 -0.001 -3 0.515
PAK5PAK5 0.645 0.036 -2 0.639
TGFBR2TGFBR2 0.644 -0.083 -2 0.477
PKCEPKCE 0.644 0.045 2 0.607
MOKMOK 0.644 0.049 1 0.592
DYRK1BDYRK1B 0.644 0.020 1 0.496
P38GP38G 0.644 0.025 1 0.385
AKT1AKT1 0.644 0.014 -3 0.447
CAMK1GCAMK1G 0.644 -0.018 -3 0.467
JNK3JNK3 0.643 0.018 1 0.467
NEK5NEK5 0.643 0.093 1 0.597
LKB1LKB1 0.643 0.090 -3 0.607
FAM20CFAM20C 0.642 -0.002 2 0.459
ATMATM 0.642 -0.013 1 0.606
IKKAIKKA 0.642 -0.067 -2 0.530
SRPK3SRPK3 0.642 -0.035 -3 0.429
GRK1GRK1 0.642 -0.034 -2 0.537
AURAAURA 0.642 0.040 -2 0.558
GSK3BGSK3B 0.641 0.045 4 0.453
ERK7ERK7 0.641 0.031 2 0.483
ERK2ERK2 0.641 -0.010 1 0.478
YSK4YSK4 0.641 -0.048 1 0.508
LATS1LATS1 0.641 0.030 -3 0.611
GSK3AGSK3A 0.640 0.056 4 0.457
PRP4PRP4 0.640 0.002 -3 0.518
PAK4PAK4 0.640 0.043 -2 0.626
TLK2TLK2 0.640 -0.010 1 0.570
AKT3AKT3 0.640 0.023 -3 0.386
CDK2CDK2 0.640 -0.004 1 0.511
SNRKSNRK 0.640 -0.064 2 0.516
CAMK2ACAMK2A 0.639 -0.024 2 0.632
DAPK3DAPK3 0.639 0.063 -3 0.518
MARK1MARK1 0.639 -0.007 4 0.675
PINK1PINK1 0.638 -0.073 1 0.642
PHKG2PHKG2 0.638 -0.041 -3 0.518
BMPR1BBMPR1B 0.638 -0.013 1 0.556
TTBK2TTBK2 0.638 -0.129 2 0.544
DLKDLK 0.638 -0.159 1 0.545
DRAK1DRAK1 0.638 -0.023 1 0.526
GRK6GRK6 0.637 -0.109 1 0.580
PBKPBK 0.637 0.099 1 0.630
MLK4MLK4 0.637 -0.056 2 0.603
CDK6CDK6 0.636 0.019 1 0.461
ROCK2ROCK2 0.636 0.068 -3 0.513
MEK5MEK5 0.636 -0.064 2 0.681
CAMK1DCAMK1D 0.635 -0.015 -3 0.432
PERKPERK 0.635 -0.063 -2 0.542
MAPKAPK5MAPKAPK5 0.635 -0.088 -3 0.422
CAMK2BCAMK2B 0.635 -0.043 2 0.593
MRCKBMRCKB 0.635 0.034 -3 0.456
PKN1PKN1 0.635 -0.015 -3 0.451
CK1ECK1E 0.635 -0.051 -3 0.372
SMMLCKSMMLCK 0.634 -0.006 -3 0.521
P70S6KP70S6K 0.634 -0.046 -3 0.419
GRK7GRK7 0.633 -0.051 1 0.555
NEK4NEK4 0.633 0.034 1 0.533
MEKK1MEKK1 0.633 -0.026 1 0.540
CDK4CDK4 0.633 0.012 1 0.442
CAMKK1CAMKK1 0.633 0.007 -2 0.594
TAO3TAO3 0.633 -0.004 1 0.535
DCAMKL2DCAMKL2 0.632 -0.018 -3 0.547
MEKK2MEKK2 0.632 -0.039 2 0.658
LOKLOK 0.632 0.020 -2 0.644
HRIHRI 0.632 -0.094 -2 0.577
TGFBR1TGFBR1 0.632 -0.045 -2 0.485
PLK4PLK4 0.632 -0.008 2 0.437
SGK1SGK1 0.632 0.007 -3 0.353
NEK1NEK1 0.631 0.081 1 0.563
ALK4ALK4 0.631 -0.085 -2 0.526
DAPK1DAPK1 0.631 0.033 -3 0.498
CAMKK2CAMKK2 0.631 0.022 -2 0.609
MEKK6MEKK6 0.630 0.027 1 0.516
CK1G1CK1G1 0.630 -0.063 -3 0.354
GAKGAK 0.629 0.045 1 0.668
TNIKTNIK 0.628 0.050 3 0.727
PDK1PDK1 0.628 -0.009 1 0.548
HPK1HPK1 0.628 0.010 1 0.491
CK1DCK1D 0.628 -0.056 -3 0.339
GRK4GRK4 0.628 -0.168 -2 0.528
HGKHGK 0.627 0.010 3 0.715
HASPINHASPIN 0.627 0.105 -1 0.731
CAMK1ACAMK1A 0.627 -0.013 -3 0.405
NEK3NEK3 0.627 0.044 1 0.502
PASKPASK 0.627 -0.010 -3 0.594
CHK2CHK2 0.627 -0.026 -3 0.384
ZAKZAK 0.627 -0.084 1 0.478
TAO2TAO2 0.627 -0.025 2 0.697
STK33STK33 0.626 -0.014 2 0.476
LRRK2LRRK2 0.626 0.017 2 0.688
MRCKAMRCKA 0.625 0.002 -3 0.469
ACVR2BACVR2B 0.625 -0.079 -2 0.470
MEKK3MEKK3 0.625 -0.130 1 0.527
CK1A2CK1A2 0.625 -0.060 -3 0.330
DMPK1DMPK1 0.625 0.051 -3 0.481
SBKSBK 0.625 -0.021 -3 0.330
PLK1PLK1 0.625 -0.122 -2 0.508
PKG1PKG1 0.624 0.008 -2 0.560
TLK1TLK1 0.624 -0.095 -2 0.505
NEK11NEK11 0.624 -0.068 1 0.498
NEK8NEK8 0.624 -0.069 2 0.669
KHS2KHS2 0.624 0.035 1 0.498
BRAFBRAF 0.624 -0.109 -4 0.399
ACVR2AACVR2A 0.623 -0.102 -2 0.464
ALK2ALK2 0.623 -0.078 -2 0.486
KHS1KHS1 0.623 0.033 1 0.494
LIMK2_TYRLIMK2_TYR 0.622 0.163 -3 0.623
ROCK1ROCK1 0.622 0.037 -3 0.463
MAP3K15MAP3K15 0.622 0.001 1 0.483
MEK2MEK2 0.622 -0.007 2 0.653
MINKMINK 0.622 -0.006 1 0.496
IRAK1IRAK1 0.622 -0.128 -1 0.659
YSK1YSK1 0.622 0.013 2 0.681
PDHK3_TYRPDHK3_TYR 0.621 0.216 4 0.711
CK2A2CK2A2 0.621 0.056 1 0.686
JNK1JNK1 0.620 -0.007 1 0.442
GCKGCK 0.620 -0.020 1 0.504
SLKSLK 0.620 -0.029 -2 0.582
CRIKCRIK 0.619 0.011 -3 0.454
MYO3BMYO3B 0.619 0.063 2 0.695
VRK1VRK1 0.619 0.067 2 0.640
PLK3PLK3 0.618 -0.125 2 0.597
CK2A1CK2A1 0.617 0.062 1 0.671
EEF2KEEF2K 0.616 -0.037 3 0.658
TAK1TAK1 0.615 -0.069 1 0.536
TTBK1TTBK1 0.615 -0.144 2 0.466
TNK2TNK2 0.615 0.148 3 0.657
BMPR1ABMPR1A 0.614 -0.063 1 0.541
GRK2GRK2 0.614 -0.122 -2 0.439
PKMYT1_TYRPKMYT1_TYR 0.614 0.104 3 0.691
TESK1_TYRTESK1_TYR 0.614 0.062 3 0.703
BIKEBIKE 0.613 0.071 1 0.614
MST2MST2 0.611 -0.091 1 0.524
PDHK4_TYRPDHK4_TYR 0.611 0.065 2 0.726
MAP2K4_TYRMAP2K4_TYR 0.610 0.044 -1 0.682
RIPK2RIPK2 0.609 -0.145 1 0.460
MAP2K7_TYRMAP2K7_TYR 0.606 -0.039 2 0.683
LIMK1_TYRLIMK1_TYR 0.606 0.005 2 0.682
AAK1AAK1 0.606 0.096 1 0.549
TAO1TAO1 0.604 -0.026 1 0.464
ABL1ABL1 0.603 0.047 -1 0.641
MAP2K6_TYRMAP2K6_TYR 0.603 -0.030 -1 0.669
TNK1TNK1 0.603 0.072 3 0.652
ABL2ABL2 0.602 0.044 -1 0.633
PINK1_TYRPINK1_TYR 0.602 -0.105 1 0.629
MYO3AMYO3A 0.602 -0.027 1 0.529
OSR1OSR1 0.602 -0.033 2 0.682
GRK3GRK3 0.602 -0.117 -2 0.391
MST1MST1 0.600 -0.122 1 0.509
CK1ACK1A 0.599 -0.076 -3 0.276
NEK10_TYRNEK10_TYR 0.598 0.005 1 0.497
RETRET 0.598 -0.040 1 0.558
PDHK1_TYRPDHK1_TYR 0.598 -0.089 -1 0.659
TYRO3TYRO3 0.597 -0.008 3 0.659
EPHA6EPHA6 0.597 0.028 -1 0.640
ASK1ASK1 0.597 -0.043 1 0.480
TNNI3K_TYRTNNI3K_TYR 0.596 0.029 1 0.521
MST1RMST1R 0.596 -0.048 3 0.668
TXKTXK 0.595 0.072 1 0.618
BMPR2_TYRBMPR2_TYR 0.595 -0.088 -1 0.650
DDR1DDR1 0.595 -0.025 4 0.663
BLKBLK 0.595 0.063 -1 0.630
TYK2TYK2 0.595 -0.081 1 0.551
ROS1ROS1 0.595 -0.031 3 0.646
JAK2JAK2 0.594 -0.060 1 0.526
LCKLCK 0.594 0.026 -1 0.629
EPHB4EPHB4 0.593 0.003 -1 0.628
YANK3YANK3 0.593 -0.057 2 0.292
TTKTTK 0.593 -0.066 -2 0.514
HCKHCK 0.593 0.000 -1 0.636
JAK1JAK1 0.592 0.009 1 0.475
CSF1RCSF1R 0.592 -0.043 3 0.671
YES1YES1 0.592 -0.030 -1 0.669
PLK2PLK2 0.591 -0.117 -3 0.502
AXLAXL 0.590 0.015 3 0.646
FGRFGR 0.589 -0.057 1 0.613
MERTKMERTK 0.588 0.024 3 0.652
SRMSSRMS 0.588 -0.016 1 0.596
WEE1_TYRWEE1_TYR 0.586 -0.034 -1 0.598
JAK3JAK3 0.585 -0.073 1 0.548
KDRKDR 0.584 -0.054 3 0.638
EPHB3EPHB3 0.584 -0.017 -1 0.614
FERFER 0.584 -0.091 1 0.631
ITKITK 0.584 -0.022 -1 0.634
EPHA4EPHA4 0.581 -0.054 2 0.604
EPHA1EPHA1 0.581 -0.008 3 0.640
ALPHAK3ALPHAK3 0.581 -0.127 -1 0.561
BTKBTK 0.580 -0.088 -1 0.636
EPHB1EPHB1 0.580 -0.065 1 0.563
KITKIT 0.580 -0.087 3 0.655
TECTEC 0.579 -0.038 -1 0.614
FLT3FLT3 0.578 -0.134 3 0.657
TEKTEK 0.578 -0.088 3 0.610
LYNLYN 0.578 -0.036 3 0.603
FGFR2FGFR2 0.578 -0.104 3 0.637
PTK2BPTK2B 0.578 -0.004 -1 0.651
FYNFYN 0.577 -0.027 -1 0.598
PDGFRAPDGFRA 0.577 -0.137 3 0.666
CK1G3CK1G3 0.576 -0.087 -3 0.242
DDR2DDR2 0.576 -0.014 3 0.599
STLK3STLK3 0.576 -0.127 1 0.471
PDGFRBPDGFRB 0.576 -0.147 3 0.653
BMXBMX 0.575 -0.042 -1 0.559
METMET 0.575 -0.085 3 0.655
PTK6PTK6 0.575 -0.120 -1 0.597
EPHB2EPHB2 0.575 -0.066 -1 0.605
LTKLTK 0.575 -0.083 3 0.594
INSRRINSRR 0.574 -0.132 3 0.605
FGFR1FGFR1 0.574 -0.112 3 0.617
ALKALK 0.574 -0.100 3 0.569
EPHA7EPHA7 0.574 -0.047 2 0.609
FRKFRK 0.573 -0.067 -1 0.644
EPHA3EPHA3 0.571 -0.085 2 0.569
SRCSRC 0.569 -0.058 -1 0.617
MATKMATK 0.568 -0.088 -1 0.559
FLT1FLT1 0.568 -0.136 -1 0.582
NTRK1NTRK1 0.566 -0.166 -1 0.607
NTRK3NTRK3 0.565 -0.108 -1 0.559
FGFR3FGFR3 0.565 -0.129 3 0.614
ERBB2ERBB2 0.564 -0.155 1 0.517
YANK2YANK2 0.563 -0.078 2 0.311
NTRK2NTRK2 0.563 -0.178 3 0.614
INSRINSR 0.563 -0.137 3 0.604
CSKCSK 0.562 -0.114 2 0.597
EPHA5EPHA5 0.562 -0.075 2 0.584
EPHA8EPHA8 0.562 -0.083 -1 0.580
FLT4FLT4 0.562 -0.161 3 0.631
MUSKMUSK 0.561 -0.088 1 0.478
PTK2PTK2 0.559 -0.062 -1 0.551
FGFR4FGFR4 0.557 -0.110 -1 0.559
EGFREGFR 0.554 -0.107 1 0.445
EPHA2EPHA2 0.554 -0.081 -1 0.543
SYKSYK 0.548 -0.108 -1 0.509
ERBB4ERBB4 0.548 -0.077 1 0.468
CK1G2CK1G2 0.547 -0.104 -3 0.301
FESFES 0.546 -0.096 -1 0.552
ZAP70ZAP70 0.543 -0.049 -1 0.468
IGF1RIGF1R 0.542 -0.161 3 0.538