Motif 315 (n=89)

Position-wise Probabilities
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uniprot genes site source protein function
A2A288 ZC3H12D S329 ochoa Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}.
A6NEL2 SOWAHB S258 ochoa Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) None
H0YHG0 None S431 ochoa DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}.
O00429 DNM1L S529 ochoa Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.
O14526 FCHO1 S372 ochoa F-BAR domain only protein 1 Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}.
O15534 PER1 S1006 ochoa Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}.
O43147 SGSM2 S123 ochoa Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1) Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). {ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:26620560}.
O43248 HOXC11 S210 ochoa Homeobox protein Hox-C11 (Homeobox protein Hox-3H) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
O60292 SIPA1L3 S1667 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60336 MAPKBP1 S1198 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
P0C7X2 ZNF688 S131 ochoa Zinc finger protein 688 May be involved in transcriptional regulation.
P12882 MYH1 Y389 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P13535 MYH8 Y389 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P14550 AKR1A1 S211 ochoa Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318, PubMed:30538128). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:11306097, PubMed:18276838). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838, ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033}.
P14635 CCNB1 S35 ochoa G2/mitotic-specific cyclin-B1 Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}.
P17677 GAP43 S131 ochoa Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
P18031 PTPN1 S216 ochoa Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P23193 TCEA1 S135 ochoa Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
P31327 CPS1 S1193 ochoa Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
P41440 SLC19A1 S485 ochoa Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}.
P42684 ABL2 S618 ochoa Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.
P43686 PSMC4 S19 ochoa 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}.
P48634 PRRC2A S1328 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48730 CSNK1D S328 ochoa Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.
P53814 SMTN S790 ochoa Smoothelin Structural protein of the cytoskeleton.
P55884 EIF3B S85 ochoa Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P55884 EIF3B S125 ochoa Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P57075 UBASH3A S382 ochoa Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1) Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17382318, ECO:0000269|PubMed:18189269}.
P78367 NKX3-2 S73 ochoa Homeobox protein Nkx-3.2 (Bagpipe homeobox protein homolog 1) (Homeobox protein NK-3 homolog B) Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}.
P82979 SARNP S118 ochoa SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}.
P83369 LSM11 S21 ochoa U7 snRNA-associated Sm-like protein LSm11 Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750). {ECO:0000250|UniProtKB:Q8BUV6, ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:16914750, ECO:0000269|PubMed:33230297}.
Q01826 SATB1 S465 ochoa DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}.
Q04656 ATP7A S325 ochoa Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}.
Q13233 MAP3K1 S242 ochoa Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}.
Q13428 TCOF1 S801 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13439 GOLGA4 S27 ochoa Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.
Q13501 SQSTM1 S233 ochoa Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q14004 CDK13 S867 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q15149 PLEC S2749 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15569 TESK1 S603 ochoa Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}.
Q16825 PTPN21 S484 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q4KMQ1 TPRN S418 ochoa Taperin Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}.
Q5QJE6 DNTTIP2 S20 ochoa Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}.
Q5VST9 OBSCN S6942 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VV41 ARHGEF16 S107 ochoa Rho guanine nucleotide exchange factor 16 (Ephexin-4) Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.
Q6NZI2 CAVIN1 S40 ochoa Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
Q6P996 PDXDC1 S669 ochoa Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) None
Q6ZUT6 CCDC9B S209 ochoa Coiled-coil domain-containing protein 9B None
Q7Z434 MAVS S275 ochoa Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}.
Q7Z5L9 IRF2BP2 S131 ochoa Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.
Q7Z7C8 TAF8 S278 ochoa Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF8 is involved in forming the TFIID-B module, together with TAF5 (PubMed:33795473). Mediates both basal and activator-dependent transcription (PubMed:14580349). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (PubMed:14580349). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250|UniProtKB:Q9EQH4, ECO:0000269|PubMed:14580349, ECO:0000269|PubMed:33795473}.
Q86YP4 GATAD2A S326 ochoa Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q8N201 INTS1 S104 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8N6S5 ARL6IP6 S65 ochoa ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) None
Q8TD26 CHD6 S2674 ochoa Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}.
Q8TF72 SHROOM3 S1138 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WVB6 CHTF18 S70 ochoa Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}.
Q96HC4 PDLIM5 S319 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96I24 FUBP3 S539 ochoa Far upstream element-binding protein 3 (FUSE-binding protein 3) May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
Q96JH8 RADIL S962 ochoa Ras-associating and dilute domain-containing protein Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}.
Q96RK0 CIC S1294 ochoa Protein capicua homolog Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.
Q96T23 RSF1 S515 ochoa Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}.
Q9BV73 CEP250 S2322 ochoa Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}.
Q9BYB0 SHANK3 S686 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9C073 FAM117A S305 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9C0C2 TNKS1BP1 S369 ochoa 182 kDa tankyrase-1-binding protein None
Q9H211 CDT1 S380 ochoa DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9HCM7 FBRSL1 S141 ochoa Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) None
Q9NR33 POLE4 S32 ochoa DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}.
Q9NYV4 CDK12 S889 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9P2G1 ANKIB1 S898 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UBB6 NCDN S448 ochoa Neurochondrin Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). {ECO:0000269|PubMed:16945926, ECO:0000269|PubMed:33711248, ECO:0000305|PubMed:33711248}.
Q9UK61 TASOR S68 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9UKX2 MYH2 Y389 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9Y2J2 EPB41L3 S55 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y2U8 LEMD3 S351 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y3X0 CCDC9 S362 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y6A5 TACC3 S250 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
P36578 RPL4 S66 Sugiyama Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
Q14152 EIF3A S513 Sugiyama Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P78316 NOP14 S29 Sugiyama Nucleolar protein 14 (Nucleolar complex protein 14) Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.
P04075 ALDOA Y174 Sugiyama Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}.
P09972 ALDOC Y174 Sugiyama Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) None
P49419 ALDH7A1 T91 Sugiyama Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:21338592}.
O00273 DFFA S302 Sugiyama DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Inhibitor of the caspase-activated DNase (DFF40).
Q86TU7 SETD3 S505 Sugiyama Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.
Q14204 DYNC1H1 S3920 Sugiyama Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.
Q96J92 WNK4 S122 Sugiyama Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}.
Q9UM73 ALK S1427 Sugiyama ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.
Download
reactome_id name p -log10_p
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.000281 3.552
R-HSA-75153 Apoptotic execution phase 0.000316 3.501
R-HSA-69275 G2/M Transition 0.001408 2.851
R-HSA-453274 Mitotic G2-G2/M phases 0.001479 2.830
R-HSA-1640170 Cell Cycle 0.001225 2.912
R-HSA-69206 G1/S Transition 0.001505 2.822
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.000948 3.023
R-HSA-9909396 Circadian clock 0.001916 2.718
R-HSA-9700649 Drug resistance of ALK mutants 0.005882 2.230
R-HSA-9717301 NVP-TAE684-resistant ALK mutants 0.005882 2.230
R-HSA-9717319 brigatinib-resistant ALK mutants 0.005882 2.230
R-HSA-9717316 alectinib-resistant ALK mutants 0.005882 2.230
R-HSA-9717323 ceritinib-resistant ALK mutants 0.005882 2.230
R-HSA-9717264 ASP-3026-resistant ALK mutants 0.005882 2.230
R-HSA-9717326 crizotinib-resistant ALK mutants 0.005882 2.230
R-HSA-9717329 lorlatinib-resistant ALK mutants 0.005882 2.230
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.004146 2.382
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.002244 2.649
R-HSA-6794361 Neurexins and neuroligins 0.005547 2.256
R-HSA-9700206 Signaling by ALK in cancer 0.005570 2.254
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.005570 2.254
R-HSA-69278 Cell Cycle, Mitotic 0.002484 2.605
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.002974 2.527
R-HSA-109581 Apoptosis 0.004402 2.356
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.008775 2.057
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.008775 2.057
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.008341 2.079
R-HSA-156711 Polo-like kinase mediated events 0.008341 2.079
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.008594 2.066
R-HSA-8854518 AURKA Activation by TPX2 0.009811 2.008
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.011320 1.946
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.011320 1.946
R-HSA-5357801 Programmed Cell Death 0.010939 1.961
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.012493 1.903
R-HSA-380287 Centrosome maturation 0.013330 1.875
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.012493 1.903
R-HSA-933542 TRAF6 mediated NF-kB activation 0.013817 1.860
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.014642 1.834
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.015602 1.807
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.020065 1.698
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.021154 1.675
R-HSA-68962 Activation of the pre-replicative complex 0.019449 1.711
R-HSA-6794362 Protein-protein interactions at synapses 0.017982 1.745
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.018164 1.741
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.021506 1.667
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.040464 1.393
R-HSA-69478 G2/M DNA replication checkpoint 0.051725 1.286
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.051725 1.286
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.057306 1.242
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.057306 1.242
R-HSA-446107 Type I hemidesmosome assembly 0.062855 1.202
R-HSA-9700645 ALK mutants bind TKIs 0.068371 1.165
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.079308 1.101
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.084728 1.072
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.126971 0.896
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.132113 0.879
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.147362 0.832
R-HSA-72649 Translation initiation complex formation 0.052306 1.281
R-HSA-72702 Ribosomal scanning and start codon recognition 0.055319 1.257
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.055319 1.257
R-HSA-6782135 Dual incision in TC-NER 0.058392 1.234
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.177070 0.752
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.177070 0.752
R-HSA-167287 HIV elongation arrest and recovery 0.181921 0.740
R-HSA-167290 Pausing and recovery of HIV elongation 0.181921 0.740
R-HSA-72689 Formation of a pool of free 40S subunits 0.025218 1.598
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.034518 1.462
R-HSA-390522 Striated Muscle Contraction 0.210436 0.677
R-HSA-9948299 Ribosome-associated quality control 0.232645 0.633
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.215092 0.667
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.101554 0.993
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.129900 0.886
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.167283 0.777
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.108641 0.964
R-HSA-73856 RNA Polymerase II Transcription Termination 0.063111 1.200
R-HSA-9851151 MDK and PTN in ALK signaling 0.034784 1.459
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.086687 1.062
R-HSA-8849472 PTK6 Down-Regulation 0.040464 1.393
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.062855 1.202
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.034518 1.462
R-HSA-5696400 Dual Incision in GG-NER 0.215092 0.667
R-HSA-201556 Signaling by ALK 0.030576 1.515
R-HSA-9842860 Regulation of endogenous retroelements 0.143893 0.842
R-HSA-140342 Apoptosis induced DNA fragmentation 0.073855 1.132
R-HSA-72613 Eukaryotic Translation Initiation 0.042103 1.376
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.246932 0.607
R-HSA-9932298 Degradation of CRY and PER proteins 0.034305 1.465
R-HSA-72737 Cap-dependent Translation Initiation 0.042103 1.376
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.127929 0.893
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.116594 0.933
R-HSA-933541 TRAF6 mediated IRF7 activation 0.228898 0.640
R-HSA-176417 Phosphorylation of Emi1 0.046111 1.336
R-HSA-68952 DNA replication initiation 0.073855 1.132
R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.073855 1.132
R-HSA-209560 NF-kB is activated and signals survival 0.084728 1.072
R-HSA-176412 Phosphorylation of the APC/C 0.111361 0.953
R-HSA-68949 Orc1 removal from chromatin 0.049354 1.307
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.162346 0.790
R-HSA-73863 RNA Polymerase I Transcription Termination 0.177070 0.752
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.196303 0.707
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.219721 0.658
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.242463 0.615
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.242463 0.615
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.242463 0.615
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.124027 0.906
R-HSA-193639 p75NTR signals via NF-kB 0.106096 0.974
R-HSA-2980766 Nuclear Envelope Breakdown 0.056848 1.245
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.196303 0.707
R-HSA-209543 p75NTR recruits signalling complexes 0.090117 1.045
R-HSA-5696398 Nucleotide Excision Repair 0.152027 0.818
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.162346 0.790
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.055319 1.257
R-HSA-69052 Switching of origins to a post-replicative state 0.083174 1.080
R-HSA-68877 Mitotic Prometaphase 0.037252 1.429
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.053805 1.269
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.189616 0.722
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.242463 0.615
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.242463 0.615
R-HSA-69002 DNA Replication Pre-Initiation 0.035241 1.453
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.031800 1.498
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.040887 1.388
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.058392 1.234
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.201042 0.697
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.219721 0.658
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.219721 0.658
R-HSA-9646399 Aggrephagy 0.242463 0.615
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.251375 0.600
R-HSA-68875 Mitotic Prophase 0.187493 0.727
R-HSA-72312 rRNA processing 0.186795 0.729
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.172191 0.764
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.205753 0.687
R-HSA-9664873 Pexophagy 0.073855 1.132
R-HSA-453276 Regulation of mitotic cell cycle 0.079707 1.099
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.079707 1.099
R-HSA-205043 NRIF signals cell death from the nucleus 0.100801 0.997
R-HSA-9830674 Formation of the ureteric bud 0.157381 0.803
R-HSA-4641258 Degradation of DVL 0.228898 0.640
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.251375 0.600
R-HSA-68886 M Phase 0.032396 1.490
R-HSA-167169 HIV Transcription Elongation 0.242463 0.615
R-HSA-68867 Assembly of the pre-replicative complex 0.124008 0.907
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.051725 1.286
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.068371 1.165
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.084728 1.072
R-HSA-877312 Regulation of IFNG signaling 0.090117 1.045
R-HSA-113510 E2F mediated regulation of DNA replication 0.132113 0.879
R-HSA-429947 Deadenylation of mRNA 0.162346 0.790
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.224323 0.649
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.224323 0.649
R-HSA-4641257 Degradation of AXIN 0.228898 0.640
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.228898 0.640
R-HSA-774815 Nucleosome assembly 0.268889 0.570
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.268889 0.570
R-HSA-5656169 Termination of translesion DNA synthesis 0.186743 0.729
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.064711 1.189
R-HSA-73864 RNA Polymerase I Transcription 0.092039 1.036
R-HSA-9663891 Selective autophagy 0.112433 0.949
R-HSA-69306 DNA Replication 0.080944 1.092
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.046111 1.336
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.095475 1.020
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.152386 0.817
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.064711 1.189
R-HSA-180534 Vpu mediated degradation of CD4 0.210436 0.677
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.215092 0.667
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.215092 0.667
R-HSA-169911 Regulation of Apoptosis 0.219721 0.658
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.237968 0.623
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.251375 0.600
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.251375 0.600
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 0.181921 0.740
R-HSA-69239 Synthesis of DNA 0.033802 1.471
R-HSA-193704 p75 NTR receptor-mediated signalling 0.027716 1.557
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.063111 1.200
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.095475 1.020
R-HSA-5661270 Formation of xylulose-5-phosphate 0.116594 0.933
R-HSA-77387 Insulin receptor recycling 0.181921 0.740
R-HSA-9833109 Evasion by RSV of host interferon responses 0.196303 0.707
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.246932 0.607
R-HSA-5362768 Hh mutants are degraded by ERAD 0.246932 0.607
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.255792 0.592
R-HSA-5617833 Cilium Assembly 0.126629 0.897
R-HSA-73886 Chromosome Maintenance 0.189616 0.722
R-HSA-68882 Mitotic Anaphase 0.051531 1.288
R-HSA-9659379 Sensory processing of sound 0.093844 1.028
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.052182 1.282
R-HSA-9907900 Proteasome assembly 0.264549 0.577
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.265317 0.576
R-HSA-193648 NRAGE signals death through JNK 0.055319 1.257
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.074595 1.127
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.237968 0.623
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.237968 0.623
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.260183 0.585
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.264549 0.577
R-HSA-4608870 Asymmetric localization of PCP proteins 0.268889 0.570
R-HSA-69620 Cell Cycle Checkpoints 0.226217 0.645
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.246932 0.607
R-HSA-5205647 Mitophagy 0.215092 0.667
R-HSA-69242 S Phase 0.075581 1.122
R-HSA-6798163 Choline catabolism 0.121798 0.914
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.055319 1.257
R-HSA-70635 Urea cycle 0.172191 0.764
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.268889 0.570
R-HSA-69481 G2/M Checkpoints 0.204566 0.689
R-HSA-1632852 Macroautophagy 0.239165 0.621
R-HSA-936837 Ion transport by P-type ATPases 0.067954 1.168
R-HSA-376176 Signaling by ROBO receptors 0.144008 0.842
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.242463 0.615
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.246932 0.607
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.268889 0.570
R-HSA-9711123 Cellular response to chemical stress 0.028243 1.549
R-HSA-982772 Growth hormone receptor signaling 0.157381 0.803
R-HSA-8953854 Metabolism of RNA 0.241241 0.618
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.068371 1.165
R-HSA-446353 Cell-extracellular matrix interactions 0.106096 0.974
R-HSA-9013694 Signaling by NOTCH4 0.084925 1.071
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.116594 0.933
R-HSA-3214841 PKMTs methylate histone lysines 0.246932 0.607
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.268889 0.570
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.268889 0.570
R-HSA-9706369 Negative regulation of FLT3 0.111361 0.953
R-HSA-6807004 Negative regulation of MET activity 0.137226 0.863
R-HSA-9671555 Signaling by PDGFR in disease 0.147362 0.832
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.095660 1.019
R-HSA-199977 ER to Golgi Anterograde Transport 0.254411 0.594
R-HSA-73887 Death Receptor Signaling 0.082037 1.086
R-HSA-8878166 Transcriptional regulation by RUNX2 0.044530 1.351
R-HSA-69205 G1/S-Specific Transcription 0.027023 1.568
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.152386 0.817
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.205753 0.687
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.210436 0.677
R-HSA-5689896 Ovarian tumor domain proteases 0.228898 0.640
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.246932 0.607
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.152386 0.817
R-HSA-416482 G alpha (12/13) signalling events 0.092039 1.036
R-HSA-69541 Stabilization of p53 0.237968 0.623
R-HSA-71064 Lysine catabolism 0.228898 0.640
R-HSA-983712 Ion channel transport 0.125326 0.902
R-HSA-70263 Gluconeogenesis 0.043642 1.360
R-HSA-6807070 PTEN Regulation 0.234817 0.629
R-HSA-9824272 Somitogenesis 0.268889 0.570
R-HSA-70326 Glucose metabolism 0.181145 0.742
R-HSA-446728 Cell junction organization 0.257562 0.589
R-HSA-74160 Gene expression (Transcription) 0.073990 1.131
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.097650 1.010
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.056848 1.245
R-HSA-73857 RNA Polymerase II Transcription 0.077876 1.109
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.219721 0.658
R-HSA-70171 Glycolysis 0.139862 0.854
R-HSA-354192 Integrin signaling 0.205753 0.687
R-HSA-8853659 RET signaling 0.224323 0.649
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.268889 0.570
R-HSA-9020702 Interleukin-1 signaling 0.141875 0.848
R-HSA-196757 Metabolism of folate and pterines 0.228898 0.640
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.043642 1.360
R-HSA-3700989 Transcriptional Regulation by TP53 0.068118 1.167
R-HSA-422475 Axon guidance 0.242356 0.616
R-HSA-8986944 Transcriptional Regulation by MECP2 0.118184 0.927
R-HSA-9607240 FLT3 Signaling 0.246932 0.607
R-HSA-446652 Interleukin-1 family signaling 0.265317 0.576
R-HSA-9856651 MITF-M-dependent gene expression 0.260954 0.583
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.273204 0.564
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.273204 0.564
R-HSA-2299718 Condensation of Prophase Chromosomes 0.273204 0.564
R-HSA-9612973 Autophagy 0.274045 0.562
R-HSA-72766 Translation 0.274869 0.561
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.277494 0.557
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.277494 0.557
R-HSA-9675108 Nervous system development 0.283790 0.547
R-HSA-73893 DNA Damage Bypass 0.285998 0.544
R-HSA-9766229 Degradation of CDH1 0.285998 0.544
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.285998 0.544
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.285998 0.544
R-HSA-5658442 Regulation of RAS by GAPs 0.290213 0.537
R-HSA-2467813 Separation of Sister Chromatids 0.291485 0.535
R-HSA-1169091 Activation of NF-kappaB in B cells 0.294403 0.531
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.294403 0.531
R-HSA-5358346 Hedgehog ligand biogenesis 0.294403 0.531
R-HSA-72187 mRNA 3'-end processing 0.298569 0.525
R-HSA-112382 Formation of RNA Pol II elongation complex 0.298569 0.525
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.298569 0.525
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.298569 0.525
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.298569 0.525
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.302710 0.519
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.302710 0.519
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.302710 0.519
R-HSA-8948751 Regulation of PTEN stability and activity 0.302710 0.519
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.306827 0.513
R-HSA-3214815 HDACs deacetylate histones 0.310921 0.507
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.310921 0.507
R-HSA-9012852 Signaling by NOTCH3 0.310921 0.507
R-HSA-6798695 Neutrophil degranulation 0.311882 0.506
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.314990 0.502
R-HSA-1500931 Cell-Cell communication 0.318455 0.497
R-HSA-9764561 Regulation of CDH1 Function 0.319035 0.496
R-HSA-212436 Generic Transcription Pathway 0.322940 0.491
R-HSA-1852241 Organelle biogenesis and maintenance 0.324910 0.488
R-HSA-180786 Extension of Telomeres 0.327056 0.485
R-HSA-429914 Deadenylation-dependent mRNA decay 0.327056 0.485
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.327056 0.485
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.331031 0.480
R-HSA-8943724 Regulation of PTEN gene transcription 0.331031 0.480
R-HSA-156590 Glutathione conjugation 0.331031 0.480
R-HSA-351202 Metabolism of polyamines 0.331031 0.480
R-HSA-9793380 Formation of paraxial mesoderm 0.334982 0.475
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.342817 0.465
R-HSA-69615 G1/S DNA Damage Checkpoints 0.342817 0.465
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.342817 0.465
R-HSA-8848021 Signaling by PTK6 0.342817 0.465
R-HSA-1234174 Cellular response to hypoxia 0.350560 0.455
R-HSA-9830369 Kidney development 0.358212 0.446
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.358212 0.446
R-HSA-167172 Transcription of the HIV genome 0.362005 0.441
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.362005 0.441
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.369524 0.432
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.369524 0.432
R-HSA-204005 COPII-mediated vesicle transport 0.369524 0.432
R-HSA-69202 Cyclin E associated events during G1/S transition 0.369524 0.432
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.369524 0.432
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.371046 0.431
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.373251 0.428
R-HSA-5632684 Hedgehog 'on' state 0.373251 0.428
R-HSA-948021 Transport to the Golgi and subsequent modification 0.375261 0.426
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.376956 0.424
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.376956 0.424
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.377365 0.423
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.380639 0.419
R-HSA-8953897 Cellular responses to stimuli 0.382478 0.417
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.384301 0.415
R-HSA-69473 G2/M DNA damage checkpoint 0.384301 0.415
R-HSA-5689603 UCH proteinases 0.391560 0.407
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.391560 0.407
R-HSA-5619084 ABC transporter disorders 0.398734 0.399
R-HSA-4086400 PCP/CE pathway 0.398734 0.399
R-HSA-9730414 MITF-M-regulated melanocyte development 0.400310 0.398
R-HSA-168249 Innate Immune System 0.402165 0.396
R-HSA-9833482 PKR-mediated signaling 0.405825 0.392
R-HSA-6806834 Signaling by MET 0.405825 0.392
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.412833 0.384
R-HSA-2262752 Cellular responses to stress 0.415152 0.382
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.416306 0.381
R-HSA-8951664 Neddylation 0.416754 0.380
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.419759 0.377
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.419759 0.377
R-HSA-5687128 MAPK6/MAPK4 signaling 0.423192 0.373
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.426605 0.370
R-HSA-141424 Amplification of signal from the kinetochores 0.426605 0.370
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.426605 0.370
R-HSA-162906 HIV Infection 0.428941 0.368
R-HSA-156902 Peptide chain elongation 0.436723 0.360
R-HSA-1236974 ER-Phagosome pathway 0.440057 0.356
R-HSA-3247509 Chromatin modifying enzymes 0.442991 0.354
R-HSA-73884 Base Excision Repair 0.443370 0.353
R-HSA-202424 Downstream TCR signaling 0.443370 0.353
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.446665 0.350
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.449940 0.347
R-HSA-156842 Eukaryotic Translation Elongation 0.453196 0.344
R-HSA-74752 Signaling by Insulin receptor 0.453196 0.344
R-HSA-157118 Signaling by NOTCH 0.454885 0.342
R-HSA-1474290 Collagen formation 0.459651 0.338
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.462850 0.335
R-HSA-72764 Eukaryotic Translation Termination 0.466031 0.332
R-HSA-6807878 COPI-mediated anterograde transport 0.469192 0.329
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.469192 0.329
R-HSA-157579 Telomere Maintenance 0.472335 0.326
R-HSA-8878159 Transcriptional regulation by RUNX3 0.472335 0.326
R-HSA-4839726 Chromatin organization 0.472455 0.326
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.475460 0.323
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.475460 0.323
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.475460 0.323
R-HSA-69618 Mitotic Spindle Checkpoint 0.481655 0.317
R-HSA-5610787 Hedgehog 'off' state 0.481655 0.317
R-HSA-382556 ABC-family proteins mediated transport 0.481655 0.317
R-HSA-5688426 Deubiquitination 0.483981 0.315
R-HSA-2408557 Selenocysteine synthesis 0.484725 0.315
R-HSA-192823 Viral mRNA Translation 0.490812 0.309
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.493828 0.306
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.493828 0.306
R-HSA-9860931 Response of endothelial cells to shear stress 0.493828 0.306
R-HSA-9833110 RSV-host interactions 0.496827 0.304
R-HSA-9692914 SARS-CoV-1-host interactions 0.502772 0.299
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.505718 0.296
R-HSA-1236975 Antigen processing-Cross presentation 0.508648 0.294
R-HSA-2672351 Stimuli-sensing channels 0.508648 0.294
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.508648 0.294
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.511559 0.291
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.511559 0.291
R-HSA-202403 TCR signaling 0.514454 0.289
R-HSA-6803157 Antimicrobial peptides 0.517332 0.286
R-HSA-76002 Platelet activation, signaling and aggregation 0.519452 0.284
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.520193 0.284
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.520193 0.284
R-HSA-2871796 FCERI mediated MAPK activation 0.520193 0.284
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.523037 0.281
R-HSA-71291 Metabolism of amino acids and derivatives 0.523527 0.281
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.525865 0.279
R-HSA-9855142 Cellular responses to mechanical stimuli 0.525865 0.279
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.531470 0.275
R-HSA-909733 Interferon alpha/beta signaling 0.534248 0.272
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.535378 0.271
R-HSA-373760 L1CAM interactions 0.537010 0.270
R-HSA-5693538 Homology Directed Repair 0.542485 0.266
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.545199 0.263
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.545199 0.263
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.553244 0.257
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.553244 0.257
R-HSA-112316 Neuronal System 0.553701 0.257
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.555894 0.255
R-HSA-2132295 MHC class II antigen presentation 0.555894 0.255
R-HSA-1257604 PIP3 activates AKT signaling 0.556755 0.254
R-HSA-162909 Host Interactions of HIV factors 0.558529 0.253
R-HSA-199991 Membrane Trafficking 0.560047 0.252
R-HSA-114608 Platelet degranulation 0.568914 0.245
R-HSA-9843745 Adipogenesis 0.581556 0.235
R-HSA-8856688 Golgi-to-ER retrograde transport 0.584040 0.234
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.586510 0.232
R-HSA-3858494 Beta-catenin independent WNT signaling 0.596243 0.225
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.598641 0.223
R-HSA-5358351 Signaling by Hedgehog 0.601024 0.221
R-HSA-212165 Epigenetic regulation of gene expression 0.603274 0.219
R-HSA-9664417 Leishmania phagocytosis 0.605750 0.218
R-HSA-9664407 Parasite infection 0.605750 0.218
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.605750 0.218
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.608092 0.216
R-HSA-162599 Late Phase of HIV Life Cycle 0.612734 0.213
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.612734 0.213
R-HSA-8856828 Clathrin-mediated endocytosis 0.615035 0.211
R-HSA-2871837 FCERI mediated NF-kB activation 0.617322 0.209
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.626338 0.203
R-HSA-9758941 Gastrulation 0.628559 0.202
R-HSA-9679191 Potential therapeutics for SARS 0.630766 0.200
R-HSA-9006925 Intracellular signaling by second messengers 0.632719 0.199
R-HSA-5693532 DNA Double-Strand Break Repair 0.637312 0.196
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.639468 0.194
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.641612 0.193
R-HSA-162587 HIV Life Cycle 0.645862 0.190
R-HSA-9711097 Cellular response to starvation 0.647967 0.188
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.647967 0.188
R-HSA-877300 Interferon gamma signaling 0.650061 0.187
R-HSA-5633007 Regulation of TP53 Activity 0.652142 0.186
R-HSA-73894 DNA Repair 0.659038 0.181
R-HSA-2408522 Selenoamino acid metabolism 0.660346 0.180
R-HSA-5621481 C-type lectin receptors (CLRs) 0.676182 0.170
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.678110 0.169
R-HSA-9824446 Viral Infection Pathways 0.678257 0.169
R-HSA-5689880 Ub-specific processing proteases 0.680026 0.167
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.680026 0.167
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.680026 0.167
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.681931 0.166
R-HSA-9678108 SARS-CoV-1 Infection 0.683824 0.165
R-HSA-168255 Influenza Infection 0.691288 0.160
R-HSA-913531 Interferon Signaling 0.691787 0.160
R-HSA-201681 TCF dependent signaling in response to WNT 0.698577 0.156
R-HSA-168898 Toll-like Receptor Cascades 0.712648 0.147
R-HSA-9609690 HCMV Early Events 0.721111 0.142
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.721111 0.142
R-HSA-5653656 Vesicle-mediated transport 0.726609 0.139
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.727119 0.138
R-HSA-389948 Co-inhibition by PD-1 0.727703 0.138
R-HSA-1266738 Developmental Biology 0.738274 0.132
R-HSA-446203 Asparagine N-linked glycosylation 0.739508 0.131
R-HSA-397014 Muscle contraction 0.748080 0.126
R-HSA-418990 Adherens junctions interactions 0.756969 0.121
R-HSA-8878171 Transcriptional regulation by RUNX1 0.768339 0.114
R-HSA-9705683 SARS-CoV-2-host interactions 0.771099 0.113
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.773826 0.111
R-HSA-1280215 Cytokine Signaling in Immune system 0.781611 0.107
R-HSA-156580 Phase II - Conjugation of compounds 0.785704 0.105
R-HSA-5619115 Disorders of transmembrane transporters 0.795743 0.099
R-HSA-9609646 HCMV Infection 0.799387 0.097
R-HSA-421270 Cell-cell junction organization 0.800587 0.097
R-HSA-388841 Regulation of T cell activation by CD28 family 0.806482 0.093
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.831453 0.080
R-HSA-9658195 Leishmania infection 0.833467 0.079
R-HSA-9824443 Parasitic Infection Pathways 0.833467 0.079
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.834465 0.079
R-HSA-5673001 RAF/MAP kinase cascade 0.841289 0.075
R-HSA-5684996 MAPK1/MAPK3 signaling 0.847834 0.072
R-HSA-382551 Transport of small molecules 0.849324 0.071
R-HSA-195721 Signaling by WNT 0.849655 0.071
R-HSA-9679506 SARS-CoV Infections 0.857861 0.067
R-HSA-1474244 Extracellular matrix organization 0.876761 0.057
R-HSA-5683057 MAPK family signaling cascades 0.888103 0.052
R-HSA-9694516 SARS-CoV-2 Infection 0.889446 0.051
R-HSA-5663205 Infectious disease 0.889631 0.051
R-HSA-449147 Signaling by Interleukins 0.898343 0.047
R-HSA-196854 Metabolism of vitamins and cofactors 0.899023 0.046
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.910527 0.041
R-HSA-168256 Immune System 0.916023 0.038
R-HSA-1643685 Disease 0.929482 0.032
R-HSA-162582 Signal Transduction 0.929584 0.032
R-HSA-597592 Post-translational protein modification 0.939684 0.027
R-HSA-388396 GPCR downstream signalling 0.951646 0.022
R-HSA-109582 Hemostasis 0.954056 0.020
R-HSA-392499 Metabolism of proteins 0.959970 0.018
R-HSA-211859 Biological oxidations 0.961796 0.017
R-HSA-372790 Signaling by GPCR 0.968503 0.014
R-HSA-1280218 Adaptive Immune System 0.988512 0.005
R-HSA-9709957 Sensory Perception 0.996013 0.002
R-HSA-1430728 Metabolism 0.999963 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK4HIPK4 0.788 0.315 1 0.807
CLK3CLK3 0.785 0.240 1 0.823
PRKD1PRKD1 0.777 0.266 -3 0.844
SRPK1SRPK1 0.774 0.209 -3 0.803
HIPK2HIPK2 0.771 0.269 1 0.719
COTCOT 0.770 0.040 2 0.729
CDC7CDC7 0.769 0.097 1 0.776
KISKIS 0.766 0.150 1 0.752
DYRK2DYRK2 0.766 0.241 1 0.781
CLK2CLK2 0.766 0.224 -3 0.811
SRPK2SRPK2 0.765 0.177 -3 0.743
PRKD2PRKD2 0.765 0.154 -3 0.826
CDKL5CDKL5 0.763 0.129 -3 0.821
PIM3PIM3 0.763 0.073 -3 0.868
MTORMTOR 0.762 0.112 1 0.761
NLKNLK 0.762 0.147 1 0.828
MOSMOS 0.762 0.075 1 0.788
SKMLCKSKMLCK 0.762 0.157 -2 0.479
NDR2NDR2 0.761 0.062 -3 0.866
CDK8CDK8 0.761 0.186 1 0.747
CDK19CDK19 0.760 0.193 1 0.721
ERK5ERK5 0.760 0.103 1 0.776
CDK7CDK7 0.760 0.183 1 0.750
HIPK1HIPK1 0.760 0.243 1 0.781
JNK2JNK2 0.760 0.247 1 0.718
CDKL1CDKL1 0.759 0.113 -3 0.828
CLK1CLK1 0.759 0.225 -3 0.790
CDK18CDK18 0.758 0.200 1 0.692
PRPKPRPK 0.758 0.055 -1 0.838
ICKICK 0.758 0.142 -3 0.849
CLK4CLK4 0.756 0.167 -3 0.804
MAPKAPK2MAPKAPK2 0.756 0.122 -3 0.800
IKKBIKKB 0.755 -0.029 -2 0.400
NUAK2NUAK2 0.754 0.127 -3 0.859
MARK4MARK4 0.754 0.151 4 0.784
MAPKAPK3MAPKAPK3 0.754 0.125 -3 0.817
AURCAURC 0.754 0.031 -2 0.293
RSK2RSK2 0.753 0.067 -3 0.818
P38BP38B 0.753 0.193 1 0.717
CAMK1BCAMK1B 0.753 0.052 -3 0.855
DYRK4DYRK4 0.753 0.227 1 0.733
BMPR1BBMPR1B 0.753 0.092 1 0.758
RAF1RAF1 0.753 -0.026 1 0.759
JNK3JNK3 0.752 0.227 1 0.739
RSK3RSK3 0.752 0.076 -3 0.810
PIM1PIM1 0.752 0.084 -3 0.834
IKKAIKKA 0.751 0.015 -2 0.421
DYRK1ADYRK1A 0.751 0.205 1 0.786
SRPK3SRPK3 0.751 0.130 -3 0.775
P38AP38A 0.751 0.189 1 0.759
TBK1TBK1 0.751 -0.013 1 0.659
HIPK3HIPK3 0.750 0.238 1 0.764
CAMK2DCAMK2D 0.750 0.081 -3 0.837
CDK5CDK5 0.750 0.168 1 0.754
P90RSKP90RSK 0.750 0.076 -3 0.810
CHAK2CHAK2 0.750 0.050 -1 0.771
IKKEIKKE 0.749 -0.015 1 0.662
CDK1CDK1 0.749 0.154 1 0.732
TGFBR2TGFBR2 0.749 -0.036 -2 0.417
P38GP38G 0.749 0.194 1 0.665
TSSK2TSSK2 0.749 0.151 -5 0.791
TSSK1TSSK1 0.748 0.152 -3 0.878
BMPR2BMPR2 0.748 -0.075 -2 0.472
GRK1GRK1 0.748 0.007 -2 0.383
PKN3PKN3 0.748 0.042 -3 0.839
MST4MST4 0.748 0.032 2 0.757
PDHK4PDHK4 0.748 -0.129 1 0.776
ERK1ERK1 0.748 0.169 1 0.711
CDK17CDK17 0.747 0.170 1 0.664
DAPK2DAPK2 0.747 0.081 -3 0.852
PRKD3PRKD3 0.747 0.110 -3 0.791
NDR1NDR1 0.747 0.001 -3 0.856
CAMLCKCAMLCK 0.747 0.032 -2 0.438
ATRATR 0.747 -0.024 1 0.713
NEK6NEK6 0.746 0.000 -2 0.474
DYRK1BDYRK1B 0.746 0.202 1 0.738
CDK13CDK13 0.746 0.149 1 0.730
CAMK2ACAMK2A 0.746 0.090 2 0.683
AMPKA1AMPKA1 0.746 0.090 -3 0.864
GCN2GCN2 0.745 -0.122 2 0.663
NIKNIK 0.745 0.028 -3 0.858
DSTYKDSTYK 0.745 -0.057 2 0.765
PKN2PKN2 0.745 0.033 -3 0.849
QSKQSK 0.745 0.144 4 0.768
P38DP38D 0.744 0.195 1 0.663
AMPKA2AMPKA2 0.744 0.103 -3 0.851
PKACBPKACB 0.744 0.047 -2 0.310
WNK1WNK1 0.744 0.033 -2 0.485
LATS2LATS2 0.744 0.011 -5 0.649
ULK2ULK2 0.744 -0.061 2 0.647
MLK2MLK2 0.744 0.028 2 0.717
MAKMAK 0.743 0.202 -2 0.456
PDHK1PDHK1 0.743 -0.104 1 0.759
RSK4RSK4 0.743 0.062 -3 0.804
SIKSIK 0.742 0.136 -3 0.799
CDK3CDK3 0.742 0.159 1 0.676
P70S6KBP70S6KB 0.742 0.026 -3 0.826
LATS1LATS1 0.742 0.079 -3 0.859
PKACGPKACG 0.742 -0.008 -2 0.345
PKCDPKCD 0.742 0.032 2 0.665
BRSK1BRSK1 0.742 0.130 -3 0.827
CAMK2BCAMK2B 0.742 0.044 2 0.671
TGFBR1TGFBR1 0.741 0.030 -2 0.460
CAMK2GCAMK2G 0.741 -0.084 2 0.677
CDK9CDK9 0.741 0.155 1 0.736
CDK12CDK12 0.741 0.151 1 0.714
CDK16CDK16 0.740 0.166 1 0.668
MARK3MARK3 0.740 0.158 4 0.733
PRKXPRKX 0.739 0.051 -3 0.764
PKCBPKCB 0.739 0.054 2 0.625
MNK2MNK2 0.739 0.024 -2 0.398
FAM20CFAM20C 0.738 0.050 2 0.582
NUAK1NUAK1 0.738 0.068 -3 0.822
GRK5GRK5 0.738 -0.124 -3 0.803
MLK1MLK1 0.738 -0.090 2 0.696
AKT2AKT2 0.738 0.088 -3 0.756
PKG2PKG2 0.738 0.014 -2 0.310
NEK7NEK7 0.738 -0.093 -3 0.772
PAK1PAK1 0.738 -0.001 -2 0.399
PHKG1PHKG1 0.737 0.033 -3 0.847
DYRK3DYRK3 0.737 0.145 1 0.783
RIPK3RIPK3 0.737 -0.096 3 0.710
MARK2MARK2 0.736 0.132 4 0.709
NEK9NEK9 0.736 -0.025 2 0.702
BCKDKBCKDK 0.736 -0.085 -1 0.773
ALK4ALK4 0.736 -0.008 -2 0.469
MLK3MLK3 0.736 -0.018 2 0.639
PAK3PAK3 0.735 -0.012 -2 0.401
BRSK2BRSK2 0.735 0.083 -3 0.828
MSK2MSK2 0.735 0.027 -3 0.789
NIM1NIM1 0.735 0.019 3 0.708
MSK1MSK1 0.735 0.034 -3 0.796
DLKDLK 0.735 -0.094 1 0.752
MASTLMASTL 0.734 -0.118 -2 0.421
SGK3SGK3 0.734 0.077 -3 0.812
CHK1CHK1 0.734 0.062 -3 0.834
PRP4PRP4 0.734 0.106 -3 0.711
AURBAURB 0.734 -0.026 -2 0.285
QIKQIK 0.733 0.036 -3 0.825
CDK10CDK10 0.733 0.143 1 0.711
PKCAPKCA 0.733 0.018 2 0.620
ACVR2BACVR2B 0.733 -0.004 -2 0.446
ERK2ERK2 0.733 0.112 1 0.742
MELKMELK 0.733 0.043 -3 0.831
GRK7GRK7 0.732 -0.021 1 0.694
BMPR1ABMPR1A 0.732 0.039 1 0.743
MOKMOK 0.732 0.177 1 0.761
PKCGPKCG 0.731 -0.003 2 0.619
CDK14CDK14 0.731 0.130 1 0.720
PKACAPKACA 0.731 0.031 -2 0.286
ULK1ULK1 0.731 -0.109 -3 0.725
GRK6GRK6 0.731 -0.085 1 0.757
PIM2PIM2 0.731 0.049 -3 0.793
JNK1JNK1 0.731 0.174 1 0.708
MNK1MNK1 0.730 0.002 -2 0.402
AURAAURA 0.730 -0.035 -2 0.262
TLK2TLK2 0.730 -0.010 1 0.701
CDK2CDK2 0.730 0.071 1 0.771
MYLK4MYLK4 0.730 0.005 -2 0.387
HUNKHUNK 0.730 -0.087 2 0.642
YSK4YSK4 0.730 -0.028 1 0.699
SSTKSSTK 0.729 0.122 4 0.730
PKRPKR 0.729 -0.008 1 0.735
ALK2ALK2 0.729 -0.021 -2 0.443
DCAMKL1DCAMKL1 0.729 0.078 -3 0.834
ACVR2AACVR2A 0.729 -0.039 -2 0.424
ANKRD3ANKRD3 0.728 -0.121 1 0.740
MPSK1MPSK1 0.728 0.105 1 0.666
PAK6PAK6 0.728 -0.010 -2 0.335
MEK1MEK1 0.728 -0.061 2 0.726
IRE1IRE1 0.728 -0.067 1 0.684
PKCZPKCZ 0.727 -0.018 2 0.657
CAMK4CAMK4 0.727 -0.068 -3 0.831
ATMATM 0.727 -0.048 1 0.654
VRK2VRK2 0.727 -0.028 1 0.782
MAPKAPK5MAPKAPK5 0.727 0.042 -3 0.756
DNAPKDNAPK 0.727 0.010 1 0.624
WNK3WNK3 0.726 -0.162 1 0.710
MARK1MARK1 0.726 0.084 4 0.739
GSK3AGSK3A 0.726 0.069 4 0.445
PKCHPKCH 0.726 -0.018 2 0.597
CHAK1CHAK1 0.725 -0.039 2 0.697
GRK4GRK4 0.725 -0.151 -2 0.414
RIPK1RIPK1 0.724 -0.145 1 0.702
IRE2IRE2 0.724 -0.067 2 0.597
NEK2NEK2 0.724 -0.002 2 0.696
MLK4MLK4 0.723 -0.077 2 0.614
TTBK2TTBK2 0.723 -0.138 2 0.559
AKT1AKT1 0.723 0.053 -3 0.775
PLK1PLK1 0.722 -0.127 -2 0.406
GRK2GRK2 0.722 -0.070 -2 0.367
MST3MST3 0.721 0.022 2 0.727
PAK2PAK2 0.721 -0.075 -2 0.372
ERK7ERK7 0.721 0.056 2 0.468
PASKPASK 0.721 0.051 -3 0.867
AKT3AKT3 0.721 0.076 -3 0.716
SMG1SMG1 0.721 -0.042 1 0.661
CK1ECK1E 0.721 0.008 -3 0.524
SNRKSNRK 0.719 -0.055 2 0.556
BRAFBRAF 0.719 -0.037 -4 0.673
SGK1SGK1 0.718 0.093 -3 0.698
TAO3TAO3 0.718 0.013 1 0.718
TLK1TLK1 0.718 -0.054 -2 0.477
GSK3BGSK3B 0.718 0.016 4 0.437
CDK4CDK4 0.718 0.130 1 0.703
DRAK1DRAK1 0.718 -0.046 1 0.693
SBKSBK 0.717 0.122 -3 0.667
CDK6CDK6 0.717 0.121 1 0.699
PKCTPKCT 0.717 -0.004 2 0.608
DCAMKL2DCAMKL2 0.717 0.021 -3 0.835
P70S6KP70S6K 0.717 0.011 -3 0.755
SMMLCKSMMLCK 0.716 -0.007 -3 0.830
CAMK1DCAMK1D 0.716 0.042 -3 0.752
BUB1BUB1 0.716 0.094 -5 0.744
NEK5NEK5 0.716 -0.017 1 0.700
DAPK3DAPK3 0.715 0.038 -3 0.836
ZAKZAK 0.715 -0.087 1 0.705
MEK5MEK5 0.714 -0.138 2 0.707
CAMK1GCAMK1G 0.714 -0.014 -3 0.798
MEKK2MEKK2 0.714 -0.063 2 0.677
LKB1LKB1 0.713 0.045 -3 0.777
PINK1PINK1 0.713 -0.085 1 0.756
PERKPERK 0.713 -0.141 -2 0.436
PKCEPKCE 0.713 0.015 2 0.605
MEKK1MEKK1 0.712 -0.094 1 0.705
PLK3PLK3 0.712 -0.123 2 0.628
WNK4WNK4 0.712 -0.049 -2 0.482
PHKG2PHKG2 0.712 -0.025 -3 0.819
MAP3K15MAP3K15 0.712 0.083 1 0.686
HRIHRI 0.711 -0.143 -2 0.460
CK1G1CK1G1 0.711 -0.003 -3 0.516
PLK4PLK4 0.711 -0.101 2 0.478
CHK2CHK2 0.711 0.075 -3 0.712
PKCIPKCI 0.711 -0.033 2 0.625
CK1DCK1D 0.710 -0.015 -3 0.476
IRAK4IRAK4 0.710 -0.064 1 0.676
KHS1KHS1 0.710 0.109 1 0.713
GCKGCK 0.710 0.029 1 0.738
PKN1PKN1 0.710 0.037 -3 0.768
PDK1PDK1 0.709 0.029 1 0.698
DAPK1DAPK1 0.709 0.031 -3 0.819
TNIKTNIK 0.709 0.065 3 0.796
PAK5PAK5 0.708 -0.053 -2 0.282
MEKK6MEKK6 0.708 0.032 1 0.705
PDHK3_TYRPDHK3_TYR 0.708 0.193 4 0.820
MEKK3MEKK3 0.708 -0.170 1 0.722
GRK3GRK3 0.708 -0.077 -2 0.337
CAMKK2CAMKK2 0.708 -0.068 -2 0.395
HGKHGK 0.708 0.028 3 0.802
CAMK1ACAMK1A 0.707 0.055 -3 0.736
HPK1HPK1 0.707 0.034 1 0.727
MST2MST2 0.706 -0.042 1 0.726
NEK11NEK11 0.706 -0.063 1 0.713
CAMKK1CAMKK1 0.706 -0.112 -2 0.393
MINKMINK 0.706 0.026 1 0.713
TAO2TAO2 0.706 -0.054 2 0.719
PAK4PAK4 0.706 -0.049 -2 0.282
CK1A2CK1A2 0.705 -0.015 -3 0.482
ROCK2ROCK2 0.705 0.030 -3 0.824
MRCKBMRCKB 0.704 0.013 -3 0.787
NEK4NEK4 0.704 -0.041 1 0.689
KHS2KHS2 0.702 0.054 1 0.730
EEF2KEEF2K 0.702 -0.035 3 0.744
GAKGAK 0.701 -0.073 1 0.705
LOKLOK 0.701 -0.035 -2 0.375
CK2A2CK2A2 0.700 -0.032 1 0.673
MRCKAMRCKA 0.700 -0.010 -3 0.797
NEK8NEK8 0.699 -0.157 2 0.685
LRRK2LRRK2 0.699 -0.057 2 0.711
TAK1TAK1 0.699 -0.066 1 0.732
MAP2K4_TYRMAP2K4_TYR 0.699 0.069 -1 0.860
NEK1NEK1 0.698 -0.022 1 0.680
PKG1PKG1 0.698 -0.020 -2 0.249
LIMK2_TYRLIMK2_TYR 0.698 0.097 -3 0.854
DMPK1DMPK1 0.698 0.028 -3 0.815
TESK1_TYRTESK1_TYR 0.697 0.028 3 0.805
SLKSLK 0.697 -0.072 -2 0.340
PKMYT1_TYRPKMYT1_TYR 0.696 0.064 3 0.805
MST1MST1 0.696 -0.069 1 0.709
PBKPBK 0.695 -0.014 1 0.619
IRAK1IRAK1 0.695 -0.164 -1 0.714
MAP2K6_TYRMAP2K6_TYR 0.695 0.007 -1 0.863
YSK1YSK1 0.694 -0.030 2 0.692
CRIKCRIK 0.694 0.046 -3 0.776
VRK1VRK1 0.694 -0.083 2 0.666
HASPINHASPIN 0.694 0.051 -1 0.647
PDHK4_TYRPDHK4_TYR 0.693 -0.026 2 0.771
PDHK1_TYRPDHK1_TYR 0.693 0.045 -1 0.871
TTBK1TTBK1 0.691 -0.173 2 0.479
PLK2PLK2 0.691 -0.084 -3 0.694
MEK2MEK2 0.690 -0.129 2 0.692
ROCK1ROCK1 0.690 0.005 -3 0.798
CK2A1CK2A1 0.690 -0.044 1 0.658
OSR1OSR1 0.690 -0.050 2 0.699
EPHA6EPHA6 0.689 0.077 -1 0.819
BMPR2_TYRBMPR2_TYR 0.689 -0.028 -1 0.835
MAP2K7_TYRMAP2K7_TYR 0.689 -0.126 2 0.732
ABL2ABL2 0.686 0.045 -1 0.802
ROS1ROS1 0.686 0.014 3 0.743
STK33STK33 0.685 -0.128 2 0.494
NEK3NEK3 0.685 -0.073 1 0.662
TXKTXK 0.685 0.048 1 0.746
ASK1ASK1 0.685 0.016 1 0.676
TTKTTK 0.685 -0.086 -2 0.415
LIMK1_TYRLIMK1_TYR 0.684 -0.062 2 0.724
CSF1RCSF1R 0.684 0.006 3 0.762
EPHB4EPHB4 0.684 0.028 -1 0.799
MYO3BMYO3B 0.684 -0.013 2 0.719
RETRET 0.683 -0.045 1 0.705
ABL1ABL1 0.683 0.029 -1 0.797
JAK2JAK2 0.683 -0.010 1 0.704
PINK1_TYRPINK1_TYR 0.683 -0.158 1 0.743
CK1ACK1A 0.683 -0.018 -3 0.396
RIPK2RIPK2 0.682 -0.209 1 0.656
JAK1JAK1 0.681 0.054 1 0.668
MYO3AMYO3A 0.680 -0.043 1 0.706
TYK2TYK2 0.680 -0.068 1 0.697
FGRFGR 0.680 -0.049 1 0.708
TYRO3TYRO3 0.679 -0.067 3 0.760
TNNI3K_TYRTNNI3K_TYR 0.679 0.047 1 0.725
TNK2TNK2 0.679 0.024 3 0.733
MST1RMST1R 0.678 -0.078 3 0.778
TAO1TAO1 0.678 -0.051 1 0.654
JAK3JAK3 0.677 -0.056 1 0.695
DDR1DDR1 0.676 -0.069 4 0.714
NEK10_TYRNEK10_TYR 0.676 -0.007 1 0.598
LCKLCK 0.675 -0.009 -1 0.808
SRMSSRMS 0.675 -0.025 1 0.746
INSRRINSRR 0.675 -0.063 3 0.691
EPHA4EPHA4 0.675 -0.029 2 0.638
ITKITK 0.675 -0.030 -1 0.770
YES1YES1 0.674 -0.060 -1 0.832
YANK3YANK3 0.674 -0.066 2 0.306
BIKEBIKE 0.674 -0.054 1 0.574
FERFER 0.673 -0.084 1 0.748
BLKBLK 0.673 0.003 -1 0.819
HCKHCK 0.672 -0.046 -1 0.806
KITKIT 0.672 -0.063 3 0.758
EPHB1EPHB1 0.670 -0.047 1 0.747
TNK1TNK1 0.670 -0.029 3 0.748
PDGFRBPDGFRB 0.669 -0.104 3 0.768
EPHB2EPHB2 0.669 -0.030 -1 0.781
KDRKDR 0.669 -0.086 3 0.721
EPHB3EPHB3 0.669 -0.040 -1 0.785
FGFR2FGFR2 0.668 -0.110 3 0.730
BMXBMX 0.667 -0.030 -1 0.692
MERTKMERTK 0.667 -0.055 3 0.723
AAK1AAK1 0.667 -0.009 1 0.480
DDR2DDR2 0.667 -0.001 3 0.691
ALPHAK3ALPHAK3 0.666 -0.093 -1 0.751
METMET 0.666 -0.073 3 0.749
FGFR1FGFR1 0.666 -0.090 3 0.719
ALKALK 0.665 -0.054 3 0.693
TEKTEK 0.665 -0.108 3 0.693
TECTEC 0.665 -0.059 -1 0.714
AXLAXL 0.665 -0.081 3 0.730
STLK3STLK3 0.664 -0.125 1 0.669
EPHA7EPHA7 0.664 -0.032 2 0.632
FLT3FLT3 0.663 -0.142 3 0.763
PDGFRAPDGFRA 0.663 -0.122 3 0.768
FYNFYN 0.663 -0.041 -1 0.793
PTK2BPTK2B 0.663 -0.021 -1 0.762
LTKLTK 0.662 -0.072 3 0.719
BTKBTK 0.660 -0.123 -1 0.732
FRKFRK 0.660 -0.063 -1 0.818
EPHA1EPHA1 0.659 -0.054 3 0.731
PTK6PTK6 0.659 -0.118 -1 0.720
EPHA3EPHA3 0.658 -0.093 2 0.606
NTRK1NTRK1 0.658 -0.141 -1 0.800
LYNLYN 0.658 -0.074 3 0.705
NTRK3NTRK3 0.657 -0.080 -1 0.764
FGFR3FGFR3 0.657 -0.124 3 0.699
FLT1FLT1 0.657 -0.129 -1 0.807
INSRINSR 0.657 -0.102 3 0.686
ERBB2ERBB2 0.655 -0.139 1 0.678
CSKCSK 0.654 -0.070 2 0.635
EPHA8EPHA8 0.654 -0.061 -1 0.777
MATKMATK 0.654 -0.091 -1 0.731
NTRK2NTRK2 0.653 -0.156 3 0.710
FLT4FLT4 0.653 -0.153 3 0.711
SRCSRC 0.653 -0.072 -1 0.801
EPHA5EPHA5 0.653 -0.078 2 0.620
WEE1_TYRWEE1_TYR 0.653 -0.123 -1 0.703
EGFREGFR 0.651 -0.077 1 0.592
SYKSYK 0.651 -0.055 -1 0.754
PTK2PTK2 0.650 -0.039 -1 0.738
FGFR4FGFR4 0.647 -0.089 -1 0.758
ERBB4ERBB4 0.647 -0.044 1 0.617
YANK2YANK2 0.644 -0.089 2 0.326
CK1G3CK1G3 0.642 -0.072 -3 0.357
EPHA2EPHA2 0.642 -0.078 -1 0.735
IGF1RIGF1R 0.641 -0.116 3 0.624
MUSKMUSK 0.639 -0.117 1 0.559
CK1G2CK1G2 0.636 -0.080 -3 0.442
ZAP70ZAP70 0.634 -0.059 -1 0.674
FESFES 0.629 -0.101 -1 0.679