Motif 314 (n=188)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | S75 | ochoa | Protein FAM234B | None |
| E9PAV3 | NACA | S949 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S972 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1018 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1042 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1066 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1112 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1135 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1296 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1411 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1474 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00303 | EIF3F | S46 | psp | Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. {ECO:0000269|PubMed:21124883}. |
| O00429 | DNM1L | S544 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O00512 | BCL9 | S907 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O15156 | ZBTB7B | S487 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15534 | PER1 | S1006 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43242 | PSMD3 | S47 | ochoa | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O60264 | SMARCA5 | S47 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60346 | PHLPP1 | S139 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S140 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60548 | FOXD2 | S96 | ochoa | Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead-related transcription factor 9) (FREAC-9) | Probable transcription factor involved in embryogenesis and somatogenesis. {ECO:0000250}. |
| O75175 | CNOT3 | S541 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| O95196 | CSPG5 | S28 | ochoa | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) | May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}. |
| O95359 | TACC2 | S161 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S1768 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95785 | WIZ | S1335 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P00519 | ABL1 | S915 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P05387 | RPLP2 | S86 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P09874 | PARP1 | S372 | ochoa|psp | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DPH7 | TUBA3C | S379 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S379 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P10412 | H1-4 | S41 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10412 | H1-4 | S55 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10412 | H1-4 | S172 | psp | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10415 | BCL2 | S87 | ochoa|psp | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| P11171 | EPB41 | S540 | ochoa|psp | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11766 | ADH5 | S21 | ochoa | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P16402 | H1-3 | S42 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S56 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S41 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S55 | ochoa|psp | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16989 | YBX3 | T65 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17600 | SYN1 | S568 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17676 | CEBPB | S65 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P17676 | CEBPB | S257 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P18887 | XRCC1 | S219 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19419 | ELK1 | S194 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P20810 | CAST | S411 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P25440 | BRD2 | S305 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P29372 | MPG | S33 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P29372 | MPG | S47 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P29966 | MARCKS | S118 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S131 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S132 | ochoa|psp | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P35611 | ADD1 | S707 | psp | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P40222 | TXLNA | S35 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P40222 | TXLNA | S48 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P40925 | MDH1 | S242 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P41250 | GARS1 | S54 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P46013 | MKI67 | S2783 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46379 | BAG6 | S985 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P49006 | MARCKSL1 | S151 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49674 | CSNK1E | S354 | ochoa | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P49841 | GSK3B | T392 | ochoa | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:11430833, PubMed:12554650, PubMed:14690523, PubMed:16484495, PubMed:1846781, PubMed:20937854, PubMed:9072970). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282, PubMed:25827072, PubMed:29059170). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (PubMed:21343617). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
| P52701 | MSH6 | S41 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P53396 | ACLY | S459 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P55317 | FOXA1 | S347 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P55884 | EIF3B | S81 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P55884 | EIF3B | S117 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P68363 | TUBA1B | S379 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S379 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78414 | IRX1 | S267 | ochoa | Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1) | None |
| P80723 | BASP1 | S132 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P80723 | BASP1 | S194 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| Q02040 | AKAP17A | S511 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q07157 | TJP1 | S1180 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | S220 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12834 | CDC20 | S41 | ochoa|psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12906 | ILF3 | S506 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13045 | FLII | S418 | ochoa | Protein flightless-1 homolog | Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling. {ECO:0000250|UniProtKB:Q9JJ28, ECO:0000269|PubMed:14966289}. |
| Q13233 | MAP3K1 | S35 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13263 | TRIM28 | S45 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13367 | AP3B2 | S282 | ochoa | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Q13428 | TCOF1 | S982 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13428 | TCOF1 | T983 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14244 | MAP7 | S268 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14258 | TRIM25 | S428 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14938 | NFIX | S466 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q14978 | NOLC1 | S397 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15772 | SPEG | S557 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16254 | E2F4 | S244 | psp | Transcription factor E2F4 (E2F-4) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Q2KJY2 | KIF26B | S1016 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q53H80 | AKIRIN2 | S42 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q5QJE6 | DNTTIP2 | S21 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SRE5 | NUP188 | S1530 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5T1J5 | CHCHD2P9 | S41 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q68DK7 | MSL1 | S126 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6NV74 | CRACDL | S315 | ochoa | CRACD-like protein | None |
| Q6NZI2 | CAVIN1 | S26 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P2E9 | EDC4 | S824 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PL18 | ATAD2 | S61 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UB99 | ANKRD11 | S2374 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6ZNB6 | NFXL1 | S65 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZU67 | BEND4 | S99 | ochoa | BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) | None |
| Q71U36 | TUBA1A | S379 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z3K3 | POGZ | S721 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z7K6 | CENPV | S30 | ochoa | Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6) | Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269|PubMed:18772885}. |
| Q7Z7L8 | C11orf96 | S297 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86UP3 | ZFHX4 | S2337 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S638 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86YV5 | PRAG1 | S416 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IX07 | ZFPM1 | S733 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXU6 | SLC35F2 | S25 | ochoa | Solute carrier family 35 member F2 | Putative solute transporter. {ECO:0000305}. |
| Q8IY33 | MICALL2 | S313 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IYB3 | SRRM1 | T846 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N4B5 | PRR18 | S101 | ochoa | Proline-rich protein 18 | None |
| Q8N5H7 | SH2D3C | S433 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8N5S9 | CAMKK1 | S97 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8NAF0 | ZNF579 | S194 | ochoa | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q8NC56 | LEMD2 | S175 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8WVT3 | TRAPPC12 | S276 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WVT3 | TRAPPC12 | S290 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q92686 | NRGN | S36 | ochoa|psp | Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)] | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}. |
| Q92908 | GATA6 | S266 | psp | Transcription factor GATA-6 (GATA-binding factor 6) | Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:33082341, ECO:0000269|PubMed:9315713}. |
| Q969S3 | ZNF622 | S141 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q969T9 | WBP2 | S229 | ochoa | WW domain-binding protein 2 (WBP-2) | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). {ECO:0000250|UniProtKB:P97765, ECO:0000269|PubMed:16772533}. |
| Q969V6 | MRTFA | S794 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96B18 | DACT3 | S186 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96C12 | ARMC5 | S85 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96C12 | ARMC5 | S101 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96G74 | OTUD5 | S165 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96PK6 | RBM14 | S242 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96QE2 | SLC2A13 | S48 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96S55 | WRNIP1 | S151 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99536 | VAT1 | S44 | ochoa | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| Q9BR76 | CORO1B | S441 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BTC0 | DIDO1 | S501 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTC0 | DIDO1 | T1288 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVT8 | TMUB1 | S86 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}. |
| Q9BXA9 | SALL3 | S39 | ochoa | Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) | Probable transcription factor. |
| Q9BXI6 | TBC1D10A | S20 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BXK1 | KLF16 | S99 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BXK1 | KLF16 | S111 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BXK1 | KLF16 | S112 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9H1R3 | MYLK2 | S143 | ochoa | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9H211 | CDT1 | S31 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H3S7 | PTPN23 | S1121 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H6Z4 | RANBP3 | S355 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H7N4 | SCAF1 | S992 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8Y8 | GORASP2 | S409 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HBB8 | CDHR5 | S770 | ochoa | Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) | Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}. |
| Q9NR12 | PDLIM7 | S220 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRR5 | UBQLN4 | S98 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NY65 | TUBA8 | S379 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYB0 | TERF2IP | S111 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NZ56 | FMN2 | S319 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZ56 | FMN2 | S482 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9UBW8 | COPS7A | S232 | ochoa|psp | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9UL54 | TAOK2 | S449 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9UNF1 | MAGED2 | S85 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UQ35 | SRRM2 | S2244 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2259 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2310 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2314 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2325 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2326 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2365 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQN3 | CHMP2B | S190 | ochoa | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Q9Y261 | FOXA2 | S295 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2J2 | EPB41L3 | S55 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2U8 | LEMD3 | S327 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W2 | WBP11 | S600 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y2Y9 | KLF13 | S119 | psp | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y3L3 | SH3BP1 | S536 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y4B6 | DCAF1 | S898 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4B6 | DCAF1 | S915 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y5V3 | MAGED1 | S129 | ochoa | Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. |
| Q9Y6H1 | CHCHD2 | S41 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| Q96GM8 | TOE1 | S420 | Sugiyama | Target of EGR1 protein 1 | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}. |
| Q5T6F2 | UBAP2 | S856 | Sugiyama | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| P22102 | GART | S106 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| Q96EP5 | DAZAP1 | S208 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| P10636 | MAPT | S355 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Q9BTC0 | DIDO1 | S988 | Sugiyama | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q04637 | EIF4G1 | S1118 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| P26006 | ITGA3 | S898 | Sugiyama | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. {ECO:0000269|PubMed:32487760}. |
| Q9H1R3 | MYLK2 | S107 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| P42679 | MATK | S484 | Sugiyama | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.602759e-08 | 7.795 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.313355e-08 | 7.200 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.259831e-07 | 6.900 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.018860e-07 | 6.695 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.612279e-07 | 6.583 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.231155e-07 | 6.374 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.504072e-07 | 6.259 |
| R-HSA-9833482 | PKR-mediated signaling | 6.945276e-07 | 6.158 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.207737e-06 | 5.918 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.410890e-06 | 5.851 |
| R-HSA-1640170 | Cell Cycle | 1.630223e-06 | 5.788 |
| R-HSA-75153 | Apoptotic execution phase | 2.674808e-06 | 5.573 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.013757e-06 | 5.521 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.990941e-06 | 5.399 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.799802e-06 | 5.420 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.226150e-06 | 5.282 |
| R-HSA-109581 | Apoptosis | 5.750623e-06 | 5.240 |
| R-HSA-190861 | Gap junction assembly | 7.127468e-06 | 5.147 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.868650e-06 | 5.104 |
| R-HSA-5357801 | Programmed Cell Death | 8.403074e-06 | 5.076 |
| R-HSA-983189 | Kinesins | 1.181957e-05 | 4.927 |
| R-HSA-68882 | Mitotic Anaphase | 1.343902e-05 | 4.872 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.400649e-05 | 4.854 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.421689e-05 | 4.847 |
| R-HSA-9646399 | Aggrephagy | 1.532455e-05 | 4.815 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.932731e-05 | 4.714 |
| R-HSA-190828 | Gap junction trafficking | 2.687267e-05 | 4.571 |
| R-HSA-437239 | Recycling pathway of L1 | 3.662421e-05 | 4.436 |
| R-HSA-68886 | M Phase | 4.267265e-05 | 4.370 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.366662e-05 | 4.196 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 7.699562e-05 | 4.114 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.090840e-04 | 3.962 |
| R-HSA-9609690 | HCMV Early Events | 1.463602e-04 | 3.835 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.814060e-04 | 3.741 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.979664e-04 | 3.703 |
| R-HSA-9609646 | HCMV Infection | 2.144436e-04 | 3.669 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.112221e-04 | 3.675 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.468300e-04 | 3.608 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.593981e-04 | 3.586 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.960388e-04 | 3.529 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.175160e-04 | 3.498 |
| R-HSA-5620924 | Intraflagellar transport | 4.129928e-04 | 3.384 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.123341e-04 | 3.385 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 4.233628e-04 | 3.373 |
| R-HSA-913531 | Interferon Signaling | 5.549669e-04 | 3.256 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.176405e-04 | 3.144 |
| R-HSA-9663891 | Selective autophagy | 7.568992e-04 | 3.121 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.816888e-04 | 3.107 |
| R-HSA-9796292 | Formation of axial mesoderm | 9.169299e-04 | 3.038 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 8.674875e-04 | 3.062 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.675853e-04 | 3.014 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 9.169299e-04 | 3.038 |
| R-HSA-391251 | Protein folding | 9.787220e-04 | 3.009 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.115376e-03 | 2.953 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.127021e-03 | 2.948 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.247466e-03 | 2.904 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.322817e-03 | 2.879 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.674104e-03 | 2.776 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.716129e-03 | 2.765 |
| R-HSA-69275 | G2/M Transition | 2.032297e-03 | 2.692 |
| R-HSA-1632852 | Macroautophagy | 1.910187e-03 | 2.719 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.156765e-03 | 2.666 |
| R-HSA-2262752 | Cellular responses to stress | 2.316746e-03 | 2.635 |
| R-HSA-68877 | Mitotic Prometaphase | 2.494274e-03 | 2.603 |
| R-HSA-9612973 | Autophagy | 3.248863e-03 | 2.488 |
| R-HSA-373760 | L1CAM interactions | 3.271044e-03 | 2.485 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 3.588765e-03 | 2.445 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.136896e-03 | 2.383 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.211438e-03 | 2.376 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.747452e-03 | 2.324 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.419520e-03 | 2.355 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.776068e-03 | 2.321 |
| R-HSA-73884 | Base Excision Repair | 4.906262e-03 | 2.309 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.427428e-03 | 2.265 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 6.641126e-03 | 2.178 |
| R-HSA-2559583 | Cellular Senescence | 6.642953e-03 | 2.178 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.635799e-03 | 2.117 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.847320e-03 | 2.105 |
| R-HSA-112316 | Neuronal System | 7.914034e-03 | 2.102 |
| R-HSA-5617833 | Cilium Assembly | 8.560943e-03 | 2.067 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 8.667050e-03 | 2.062 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.667050e-03 | 2.062 |
| R-HSA-73894 | DNA Repair | 9.462761e-03 | 2.024 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.053000e-02 | 1.978 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.003940e-02 | 1.998 |
| R-HSA-9758941 | Gastrulation | 1.060381e-02 | 1.975 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.085869e-02 | 1.964 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.149210e-02 | 1.940 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.207231e-02 | 1.918 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.283280e-02 | 1.892 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.354449e-02 | 1.868 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.355927e-02 | 1.868 |
| R-HSA-73927 | Depurination | 1.362014e-02 | 1.866 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.527580e-02 | 1.816 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.519884e-02 | 1.818 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.614433e-02 | 1.792 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.519884e-02 | 1.818 |
| R-HSA-68875 | Mitotic Prophase | 1.648993e-02 | 1.783 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.704102e-02 | 1.769 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.089693e-02 | 1.680 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.089693e-02 | 1.680 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.162343e-02 | 1.665 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.162343e-02 | 1.665 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.162343e-02 | 1.665 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.162343e-02 | 1.665 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.162343e-02 | 1.665 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.162343e-02 | 1.665 |
| R-HSA-422475 | Axon guidance | 2.241272e-02 | 1.650 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.443942e-02 | 1.612 |
| R-HSA-9909396 | Circadian clock | 2.404417e-02 | 1.619 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.666388e-02 | 1.574 |
| R-HSA-9831926 | Nephron development | 2.666388e-02 | 1.574 |
| R-HSA-1221632 | Meiotic synapsis | 2.992800e-02 | 1.524 |
| R-HSA-72649 | Translation initiation complex formation | 3.118000e-02 | 1.506 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.118000e-02 | 1.506 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.226015e-02 | 1.491 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.336026e-02 | 1.477 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.376545e-02 | 1.472 |
| R-HSA-9675108 | Nervous system development | 3.405216e-02 | 1.468 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.505602e-02 | 1.455 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.509873e-02 | 1.455 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.552071e-02 | 1.450 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.572351e-02 | 1.447 |
| R-HSA-429947 | Deadenylation of mRNA | 4.318347e-02 | 1.365 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.645892e-02 | 1.438 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.784592e-02 | 1.422 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.318347e-02 | 1.365 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.784592e-02 | 1.422 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.071301e-02 | 1.390 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.645892e-02 | 1.438 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.361759e-02 | 1.360 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.361759e-02 | 1.360 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.365960e-02 | 1.360 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.365960e-02 | 1.360 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.365960e-02 | 1.360 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.829512e-02 | 1.316 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.989193e-02 | 1.302 |
| R-HSA-171306 | Packaging Of Telomere Ends | 5.116544e-02 | 1.291 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.316203e-02 | 1.274 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.000318e-02 | 1.222 |
| R-HSA-380287 | Centrosome maturation | 6.357120e-02 | 1.197 |
| R-HSA-73886 | Chromosome Maintenance | 6.181868e-02 | 1.209 |
| R-HSA-191650 | Regulation of gap junction activity | 6.348530e-02 | 1.197 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 5.116544e-02 | 1.291 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.536530e-02 | 1.257 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.653294e-02 | 1.248 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.536530e-02 | 1.257 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.348530e-02 | 1.197 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 6.254944e-02 | 1.204 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.318986e-02 | 1.274 |
| R-HSA-844455 | The NLRP1 inflammasome | 5.318986e-02 | 1.274 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.441236e-02 | 1.264 |
| R-HSA-5693538 | Homology Directed Repair | 5.790067e-02 | 1.237 |
| R-HSA-1266738 | Developmental Biology | 5.819456e-02 | 1.235 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.919139e-02 | 1.228 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.962837e-02 | 1.225 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.181868e-02 | 1.209 |
| R-HSA-199991 | Membrane Trafficking | 6.455697e-02 | 1.190 |
| R-HSA-9733709 | Cardiogenesis | 6.853332e-02 | 1.164 |
| R-HSA-69206 | G1/S Transition | 6.865236e-02 | 1.163 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.910304e-02 | 1.161 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.099409e-02 | 1.149 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 7.159342e-02 | 1.145 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.290833e-02 | 1.137 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 7.366943e-02 | 1.133 |
| R-HSA-429593 | Inositol transporters | 7.366943e-02 | 1.133 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 7.469719e-02 | 1.127 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 7.469719e-02 | 1.127 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 7.469719e-02 | 1.127 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.680546e-02 | 1.115 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 7.784332e-02 | 1.109 |
| R-HSA-176417 | Phosphorylation of Emi1 | 8.374343e-02 | 1.077 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 9.370848e-02 | 1.028 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 9.370848e-02 | 1.028 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.035658e-01 | 0.985 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 1.035658e-01 | 0.985 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.542931e-02 | 1.020 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 8.103056e-02 | 1.091 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.079263e-02 | 1.093 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.754005e-02 | 1.011 |
| R-HSA-1500620 | Meiosis | 8.281939e-02 | 1.082 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.009483e-01 | 0.996 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 8.425763e-02 | 1.074 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.009483e-01 | 0.996 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.009483e-01 | 0.996 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.079263e-02 | 1.093 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.815024e-02 | 1.055 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.042457e-01 | 0.982 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.079263e-02 | 1.093 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 9.082640e-02 | 1.042 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.106130e-02 | 1.091 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.035658e-01 | 0.985 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.035658e-01 | 0.985 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 8.425763e-02 | 1.074 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 8.425763e-02 | 1.074 |
| R-HSA-8941326 | RUNX2 regulates bone development | 8.103056e-02 | 1.091 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.043893e-01 | 0.981 |
| R-HSA-73928 | Depyrimidination | 1.043893e-01 | 0.981 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.419402e-01 | 0.848 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.419402e-01 | 0.848 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.419402e-01 | 0.848 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.419402e-01 | 0.848 |
| R-HSA-2022923 | DS-GAG biosynthesis | 1.512758e-01 | 0.820 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.512758e-01 | 0.820 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.512758e-01 | 0.820 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.605104e-01 | 0.794 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.605104e-01 | 0.794 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.605104e-01 | 0.794 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.605104e-01 | 0.794 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.605104e-01 | 0.794 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.605104e-01 | 0.794 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.876190e-01 | 0.727 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.964603e-01 | 0.707 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.052059e-01 | 0.688 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.052059e-01 | 0.688 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.052059e-01 | 0.688 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.052059e-01 | 0.688 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.138569e-01 | 0.670 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.138569e-01 | 0.670 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.308791e-01 | 0.637 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.392522e-01 | 0.621 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.475346e-01 | 0.606 |
| R-HSA-2022870 | CS-GAG biosynthesis | 2.557274e-01 | 0.592 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.220481e-01 | 0.913 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.403688e-01 | 0.853 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.403688e-01 | 0.853 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.441017e-01 | 0.841 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.516288e-01 | 0.819 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.030546e-01 | 0.518 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.030546e-01 | 0.518 |
| R-HSA-5334118 | DNA methylation | 3.181556e-01 | 0.497 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.110616e-01 | 0.954 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.100640e-01 | 0.678 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.220370e-01 | 0.654 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.171970e-01 | 0.931 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.582152e-01 | 0.588 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.025149e-01 | 0.519 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.554213e-01 | 0.808 |
| R-HSA-157579 | Telomere Maintenance | 1.156986e-01 | 0.937 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.106462e-01 | 0.508 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.605104e-01 | 0.794 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 1.876190e-01 | 0.727 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.138569e-01 | 0.670 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.140481e-01 | 0.669 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.140481e-01 | 0.669 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.441017e-01 | 0.841 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.876211e-01 | 0.541 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.785291e-01 | 0.748 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.324811e-01 | 0.878 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.749810e-01 | 0.757 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.021201e-01 | 0.694 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.340636e-01 | 0.631 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.992117e-01 | 0.701 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.229617e-01 | 0.910 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.052059e-01 | 0.688 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.087708e-01 | 0.963 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.100640e-01 | 0.678 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.229617e-01 | 0.910 |
| R-HSA-192814 | vRNA Synthesis | 1.419402e-01 | 0.848 |
| R-HSA-4839744 | Signaling by APC mutants | 1.419402e-01 | 0.848 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.512758e-01 | 0.820 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.512758e-01 | 0.820 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.512758e-01 | 0.820 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.224143e-01 | 0.653 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.224143e-01 | 0.653 |
| R-HSA-774815 | Nucleosome assembly | 1.148981e-01 | 0.940 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.148981e-01 | 0.940 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.557274e-01 | 0.592 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.403688e-01 | 0.853 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.030546e-01 | 0.518 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.181556e-01 | 0.497 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.374253e-01 | 0.862 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.392522e-01 | 0.621 |
| R-HSA-5358508 | Mismatch Repair | 2.224143e-01 | 0.653 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.638315e-01 | 0.579 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.718479e-01 | 0.566 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.180393e-01 | 0.661 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.220370e-01 | 0.654 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.936417e-01 | 0.532 |
| R-HSA-9711097 | Cellular response to starvation | 3.025425e-01 | 0.519 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.474989e-01 | 0.831 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.696451e-01 | 0.770 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.052059e-01 | 0.688 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.138569e-01 | 0.670 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.184594e-01 | 0.926 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.181556e-01 | 0.497 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.899493e-01 | 0.721 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.133165e-01 | 0.946 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.229617e-01 | 0.910 |
| R-HSA-9620244 | Long-term potentiation | 2.876211e-01 | 0.541 |
| R-HSA-525793 | Myogenesis | 2.953799e-01 | 0.530 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.021201e-01 | 0.694 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.953799e-01 | 0.530 |
| R-HSA-8939211 | ESR-mediated signaling | 1.522089e-01 | 0.818 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.229617e-01 | 0.910 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.325026e-01 | 0.878 |
| R-HSA-9659379 | Sensory processing of sound | 2.461280e-01 | 0.609 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.696451e-01 | 0.770 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.181556e-01 | 0.497 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.898016e-01 | 0.722 |
| R-HSA-1474165 | Reproduction | 2.150594e-01 | 0.667 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.786809e-01 | 0.748 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.876190e-01 | 0.727 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.953799e-01 | 0.530 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.953799e-01 | 0.530 |
| R-HSA-69306 | DNA Replication | 2.877179e-01 | 0.541 |
| R-HSA-195721 | Signaling by WNT | 1.371828e-01 | 0.863 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.052059e-01 | 0.688 |
| R-HSA-449836 | Other interleukin signaling | 2.308791e-01 | 0.637 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.113653e-01 | 0.953 |
| R-HSA-69236 | G1 Phase | 1.113653e-01 | 0.953 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.746399e-01 | 0.758 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.138569e-01 | 0.670 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.797775e-01 | 0.553 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.743432e-01 | 0.562 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.847596e-01 | 0.546 |
| R-HSA-69242 | S Phase | 1.100203e-01 | 0.959 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.325026e-01 | 0.878 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.786809e-01 | 0.748 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.052059e-01 | 0.688 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.308791e-01 | 0.637 |
| R-HSA-198753 | ERK/MAPK targets | 2.475346e-01 | 0.606 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.106462e-01 | 0.508 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.181556e-01 | 0.497 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.229617e-01 | 0.910 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.638315e-01 | 0.579 |
| R-HSA-71384 | Ethanol oxidation | 2.638315e-01 | 0.579 |
| R-HSA-9839394 | TGFBR3 expression | 2.876211e-01 | 0.541 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.300498e-01 | 0.638 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.259643e-01 | 0.646 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.180393e-01 | 0.661 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.605104e-01 | 0.794 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.403688e-01 | 0.853 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.180393e-01 | 0.661 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.251864e-01 | 0.902 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.133165e-01 | 0.946 |
| R-HSA-210991 | Basigin interactions | 2.475346e-01 | 0.606 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.100640e-01 | 0.678 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.554213e-01 | 0.808 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.797775e-01 | 0.553 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.797775e-01 | 0.553 |
| R-HSA-5688426 | Deubiquitination | 1.842351e-01 | 0.735 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.100640e-01 | 0.678 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.030546e-01 | 0.518 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.181556e-01 | 0.497 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.978076e-01 | 0.704 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.864311e-01 | 0.543 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.099594e-01 | 0.678 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.554213e-01 | 0.808 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.638315e-01 | 0.579 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.592320e-01 | 0.798 |
| R-HSA-418990 | Adherens junctions interactions | 2.636183e-01 | 0.579 |
| R-HSA-3000157 | Laminin interactions | 2.876211e-01 | 0.541 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.181556e-01 | 0.497 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.703114e-01 | 0.568 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.953799e-01 | 0.530 |
| R-HSA-9824446 | Viral Infection Pathways | 1.254596e-01 | 0.901 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.052059e-01 | 0.688 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.718479e-01 | 0.566 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.153839e-01 | 0.938 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.087795e-01 | 0.680 |
| R-HSA-5620971 | Pyroptosis | 3.106462e-01 | 0.508 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.106462e-01 | 0.508 |
| R-HSA-163685 | Integration of energy metabolism | 2.350518e-01 | 0.629 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.084842e-01 | 0.511 |
| R-HSA-9830369 | Kidney development | 1.981614e-01 | 0.703 |
| R-HSA-622312 | Inflammasomes | 3.106462e-01 | 0.508 |
| R-HSA-2028269 | Signaling by Hippo | 2.138569e-01 | 0.670 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.224143e-01 | 0.653 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.256633e-01 | 0.901 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.638315e-01 | 0.579 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.403688e-01 | 0.853 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.847596e-01 | 0.546 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.783740e-01 | 0.555 |
| R-HSA-109582 | Hemostasis | 1.725950e-01 | 0.763 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.437209e-01 | 0.613 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.025149e-01 | 0.519 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.225291e-01 | 0.491 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.255836e-01 | 0.487 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.255836e-01 | 0.487 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.255836e-01 | 0.487 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.255836e-01 | 0.487 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.265162e-01 | 0.486 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.304971e-01 | 0.481 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.304971e-01 | 0.481 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.329311e-01 | 0.478 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.329311e-01 | 0.478 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.329311e-01 | 0.478 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.329311e-01 | 0.478 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.329311e-01 | 0.478 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.344715e-01 | 0.476 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.344715e-01 | 0.476 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.344715e-01 | 0.476 |
| R-HSA-74160 | Gene expression (Transcription) | 3.355074e-01 | 0.474 |
| R-HSA-3214847 | HATs acetylate histones | 3.384392e-01 | 0.471 |
| R-HSA-1538133 | G0 and Early G1 | 3.401991e-01 | 0.468 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.401991e-01 | 0.468 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.401991e-01 | 0.468 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.401991e-01 | 0.468 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.401991e-01 | 0.468 |
| R-HSA-421270 | Cell-cell junction organization | 3.441620e-01 | 0.463 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.471475e-01 | 0.459 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.473883e-01 | 0.459 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.473883e-01 | 0.459 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.473883e-01 | 0.459 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.473883e-01 | 0.459 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.473883e-01 | 0.459 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.501181e-01 | 0.456 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.501181e-01 | 0.456 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.501181e-01 | 0.456 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.502986e-01 | 0.456 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.502986e-01 | 0.456 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.544996e-01 | 0.450 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.544996e-01 | 0.450 |
| R-HSA-2024101 | CS/DS degradation | 3.544996e-01 | 0.450 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.544996e-01 | 0.450 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.544996e-01 | 0.450 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.559087e-01 | 0.449 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.560549e-01 | 0.448 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.615339e-01 | 0.442 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 3.615339e-01 | 0.442 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.615339e-01 | 0.442 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.615339e-01 | 0.442 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.615339e-01 | 0.442 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.615339e-01 | 0.442 |
| R-HSA-168255 | Influenza Infection | 3.679073e-01 | 0.434 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.684919e-01 | 0.434 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.684919e-01 | 0.434 |
| R-HSA-169911 | Regulation of Apoptosis | 3.684919e-01 | 0.434 |
| R-HSA-381042 | PERK regulates gene expression | 3.684919e-01 | 0.434 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.684919e-01 | 0.434 |
| R-HSA-72766 | Translation | 3.694973e-01 | 0.432 |
| R-HSA-69239 | Synthesis of DNA | 3.737934e-01 | 0.427 |
| R-HSA-211000 | Gene Silencing by RNA | 3.737934e-01 | 0.427 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.737934e-01 | 0.427 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.737934e-01 | 0.427 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.753746e-01 | 0.426 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.753746e-01 | 0.426 |
| R-HSA-111933 | Calmodulin induced events | 3.753746e-01 | 0.426 |
| R-HSA-111997 | CaM pathway | 3.753746e-01 | 0.426 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.753746e-01 | 0.426 |
| R-HSA-8853659 | RET signaling | 3.753746e-01 | 0.426 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.753746e-01 | 0.426 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.776770e-01 | 0.423 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.776837e-01 | 0.423 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.815506e-01 | 0.418 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.821826e-01 | 0.418 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.821826e-01 | 0.418 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.821826e-01 | 0.418 |
| R-HSA-4641258 | Degradation of DVL | 3.821826e-01 | 0.418 |
| R-HSA-4641257 | Degradation of AXIN | 3.821826e-01 | 0.418 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.821826e-01 | 0.418 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.889169e-01 | 0.410 |
| R-HSA-8875878 | MET promotes cell motility | 3.889169e-01 | 0.410 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.889169e-01 | 0.410 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.931098e-01 | 0.405 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.931098e-01 | 0.405 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.955782e-01 | 0.403 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.955782e-01 | 0.403 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.955782e-01 | 0.403 |
| R-HSA-69541 | Stabilization of p53 | 3.955782e-01 | 0.403 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.969415e-01 | 0.401 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.007621e-01 | 0.397 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.021672e-01 | 0.396 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.021672e-01 | 0.396 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.021672e-01 | 0.396 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.021672e-01 | 0.396 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.021672e-01 | 0.396 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.021672e-01 | 0.396 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.021672e-01 | 0.396 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.021672e-01 | 0.396 |
| R-HSA-162582 | Signal Transduction | 4.032379e-01 | 0.394 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.078896e-01 | 0.389 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.083693e-01 | 0.389 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.086849e-01 | 0.389 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.086849e-01 | 0.389 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.086849e-01 | 0.389 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.086849e-01 | 0.389 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.086849e-01 | 0.389 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.086849e-01 | 0.389 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.086849e-01 | 0.389 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.086849e-01 | 0.389 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.086849e-01 | 0.389 |
| R-HSA-446728 | Cell junction organization | 4.106808e-01 | 0.386 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.119513e-01 | 0.385 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.131272e-01 | 0.384 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.151319e-01 | 0.382 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.151319e-01 | 0.382 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.151319e-01 | 0.382 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.196921e-01 | 0.377 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.215089e-01 | 0.375 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.215089e-01 | 0.375 |
| R-HSA-111996 | Ca-dependent events | 4.215089e-01 | 0.375 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.215089e-01 | 0.375 |
| R-HSA-165159 | MTOR signalling | 4.215089e-01 | 0.375 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.271797e-01 | 0.369 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.271797e-01 | 0.369 |
| R-HSA-9710421 | Defective pyroptosis | 4.278169e-01 | 0.369 |
| R-HSA-8854214 | TBC/RABGAPs | 4.278169e-01 | 0.369 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.278169e-01 | 0.369 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.293195e-01 | 0.367 |
| R-HSA-9907900 | Proteasome assembly | 4.340564e-01 | 0.362 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.340564e-01 | 0.362 |
| R-HSA-5683826 | Surfactant metabolism | 4.340564e-01 | 0.362 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.340564e-01 | 0.362 |
| R-HSA-3371556 | Cellular response to heat stress | 4.346169e-01 | 0.362 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.383162e-01 | 0.358 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.383162e-01 | 0.358 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.402283e-01 | 0.356 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.402283e-01 | 0.356 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.402283e-01 | 0.356 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.402283e-01 | 0.356 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.402283e-01 | 0.356 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.402283e-01 | 0.356 |
| R-HSA-9824272 | Somitogenesis | 4.402283e-01 | 0.356 |
| R-HSA-72172 | mRNA Splicing | 4.436548e-01 | 0.353 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.456753e-01 | 0.351 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.463333e-01 | 0.350 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.463333e-01 | 0.350 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.463333e-01 | 0.350 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 4.463333e-01 | 0.350 |
| R-HSA-9675135 | Diseases of DNA repair | 4.463333e-01 | 0.350 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.463333e-01 | 0.350 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.529809e-01 | 0.344 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.529809e-01 | 0.344 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.529809e-01 | 0.344 |
| R-HSA-212436 | Generic Transcription Pathway | 4.553800e-01 | 0.342 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.583453e-01 | 0.339 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.583453e-01 | 0.339 |
| R-HSA-114608 | Platelet degranulation | 4.602319e-01 | 0.337 |
| R-HSA-69481 | G2/M Checkpoints | 4.602319e-01 | 0.337 |
| R-HSA-8953854 | Metabolism of RNA | 4.606165e-01 | 0.337 |
| R-HSA-9766229 | Degradation of CDH1 | 4.642538e-01 | 0.333 |
| R-HSA-73893 | DNA Damage Bypass | 4.642538e-01 | 0.333 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.642538e-01 | 0.333 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.642538e-01 | 0.333 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.690966e-01 | 0.329 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.700982e-01 | 0.328 |
| R-HSA-912446 | Meiotic recombination | 4.758792e-01 | 0.323 |
| R-HSA-9864848 | Complex IV assembly | 4.758792e-01 | 0.323 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.758792e-01 | 0.323 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.758792e-01 | 0.323 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.758792e-01 | 0.323 |
| R-HSA-9843745 | Adipogenesis | 4.781131e-01 | 0.320 |
| R-HSA-72187 | mRNA 3'-end processing | 4.815974e-01 | 0.317 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.815974e-01 | 0.317 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.815974e-01 | 0.317 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.815974e-01 | 0.317 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.851647e-01 | 0.314 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.872537e-01 | 0.312 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.872537e-01 | 0.312 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.928485e-01 | 0.307 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.983827e-01 | 0.302 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 4.983827e-01 | 0.302 |
| R-HSA-1500931 | Cell-Cell communication | 5.015499e-01 | 0.300 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.038568e-01 | 0.298 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.038568e-01 | 0.298 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.038568e-01 | 0.298 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.059632e-01 | 0.296 |
| R-HSA-162906 | HIV Infection | 5.076076e-01 | 0.294 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.092715e-01 | 0.293 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.103038e-01 | 0.292 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.109509e-01 | 0.292 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.146275e-01 | 0.289 |
| R-HSA-180786 | Extension of Telomeres | 5.199253e-01 | 0.284 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.199253e-01 | 0.284 |
| R-HSA-191859 | snRNP Assembly | 5.199253e-01 | 0.284 |
| R-HSA-186712 | Regulation of beta-cell development | 5.199253e-01 | 0.284 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.228767e-01 | 0.282 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.228767e-01 | 0.282 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.251656e-01 | 0.280 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.251656e-01 | 0.280 |
| R-HSA-351202 | Metabolism of polyamines | 5.251656e-01 | 0.280 |
| R-HSA-379724 | tRNA Aminoacylation | 5.251656e-01 | 0.280 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.251656e-01 | 0.280 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.303491e-01 | 0.275 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.303491e-01 | 0.275 |
| R-HSA-112043 | PLC beta mediated events | 5.303491e-01 | 0.275 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.303491e-01 | 0.275 |
| R-HSA-450294 | MAP kinase activation | 5.303491e-01 | 0.275 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.354762e-01 | 0.271 |
| R-HSA-1268020 | Mitochondrial protein import | 5.354762e-01 | 0.271 |
| R-HSA-373755 | Semaphorin interactions | 5.405478e-01 | 0.267 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.426578e-01 | 0.265 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.455642e-01 | 0.263 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.491248e-01 | 0.260 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.505262e-01 | 0.259 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.554343e-01 | 0.255 |
| R-HSA-9609507 | Protein localization | 5.587054e-01 | 0.253 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.601407e-01 | 0.252 |
| R-HSA-112040 | G-protein mediated events | 5.602891e-01 | 0.252 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.618668e-01 | 0.250 |
| R-HSA-449147 | Signaling by Interleukins | 5.624862e-01 | 0.250 |
| R-HSA-5218859 | Regulated Necrosis | 5.650913e-01 | 0.248 |
| R-HSA-9610379 | HCMV Late Events | 5.712542e-01 | 0.243 |
| R-HSA-162587 | HIV Life Cycle | 5.712542e-01 | 0.243 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.745396e-01 | 0.241 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.745396e-01 | 0.241 |
| R-HSA-448424 | Interleukin-17 signaling | 5.745396e-01 | 0.241 |
| R-HSA-877300 | Interferon gamma signaling | 5.774317e-01 | 0.238 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.791869e-01 | 0.237 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.791869e-01 | 0.237 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.824732e-01 | 0.235 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.837838e-01 | 0.234 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.837838e-01 | 0.234 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.883307e-01 | 0.230 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.928283e-01 | 0.227 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.928283e-01 | 0.227 |
| R-HSA-8852135 | Protein ubiquitination | 5.972769e-01 | 0.224 |
| R-HSA-5689603 | UCH proteinases | 6.016773e-01 | 0.221 |
| R-HSA-5663205 | Infectious disease | 6.050276e-01 | 0.218 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.060298e-01 | 0.218 |
| R-HSA-216083 | Integrin cell surface interactions | 6.103350e-01 | 0.214 |
| R-HSA-5619084 | ABC transporter disorders | 6.103350e-01 | 0.214 |
| R-HSA-4086400 | PCP/CE pathway | 6.103350e-01 | 0.214 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.131325e-01 | 0.212 |
| R-HSA-6806834 | Signaling by MET | 6.188057e-01 | 0.208 |
| R-HSA-1280218 | Adaptive Immune System | 6.226935e-01 | 0.206 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.229721e-01 | 0.206 |
| R-HSA-977225 | Amyloid fiber formation | 6.229721e-01 | 0.206 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.311695e-01 | 0.200 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.311695e-01 | 0.200 |
| R-HSA-611105 | Respiratory electron transport | 6.356345e-01 | 0.197 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.391898e-01 | 0.194 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.431346e-01 | 0.192 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.431346e-01 | 0.192 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.431346e-01 | 0.192 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.431970e-01 | 0.192 |
| R-HSA-168256 | Immune System | 6.498448e-01 | 0.187 |
| R-HSA-156902 | Peptide chain elongation | 6.547136e-01 | 0.184 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.584897e-01 | 0.181 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.622246e-01 | 0.179 |
| R-HSA-202424 | Downstream TCR signaling | 6.622246e-01 | 0.179 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.623140e-01 | 0.179 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.659190e-01 | 0.177 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.659190e-01 | 0.177 |
| R-HSA-597592 | Post-translational protein modification | 6.674010e-01 | 0.176 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.700078e-01 | 0.174 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.711508e-01 | 0.173 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.725409e-01 | 0.172 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.731876e-01 | 0.172 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.731876e-01 | 0.172 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.802990e-01 | 0.167 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.837968e-01 | 0.165 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.872565e-01 | 0.163 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.906785e-01 | 0.161 |
| R-HSA-422356 | Regulation of insulin secretion | 6.974114e-01 | 0.157 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.993793e-01 | 0.155 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.007230e-01 | 0.154 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.039985e-01 | 0.152 |
| R-HSA-70171 | Glycolysis | 7.039985e-01 | 0.152 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.039985e-01 | 0.152 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.072384e-01 | 0.150 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.072384e-01 | 0.150 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.104430e-01 | 0.148 |
| R-HSA-192823 | Viral mRNA Translation | 7.136127e-01 | 0.147 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.167480e-01 | 0.145 |
| R-HSA-111885 | Opioid Signalling | 7.167480e-01 | 0.145 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.167480e-01 | 0.145 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.198491e-01 | 0.143 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.198491e-01 | 0.143 |
| R-HSA-9833110 | RSV-host interactions | 7.198491e-01 | 0.143 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.229164e-01 | 0.141 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.259504e-01 | 0.139 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.289513e-01 | 0.137 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.319195e-01 | 0.136 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.319195e-01 | 0.136 |
| R-HSA-392499 | Metabolism of proteins | 7.354963e-01 | 0.133 |
| R-HSA-202403 | TCR signaling | 7.377594e-01 | 0.132 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.377594e-01 | 0.132 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.377594e-01 | 0.132 |
| R-HSA-8951664 | Neddylation | 7.414470e-01 | 0.130 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.434728e-01 | 0.129 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.434728e-01 | 0.129 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.462829e-01 | 0.127 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.490623e-01 | 0.125 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.545308e-01 | 0.122 |
| R-HSA-9679506 | SARS-CoV Infections | 7.575906e-01 | 0.121 |
| R-HSA-70326 | Glucose metabolism | 7.625121e-01 | 0.118 |
| R-HSA-72312 | rRNA processing | 7.634412e-01 | 0.117 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.651147e-01 | 0.116 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.672624e-01 | 0.115 |
| R-HSA-157118 | Signaling by NOTCH | 7.784074e-01 | 0.109 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.908206e-01 | 0.102 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.919381e-01 | 0.101 |
| R-HSA-4839726 | Chromatin organization | 7.942535e-01 | 0.100 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.964770e-01 | 0.099 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.031013e-01 | 0.095 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.136689e-01 | 0.090 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.157137e-01 | 0.088 |
| R-HSA-6807070 | PTEN Regulation | 8.197367e-01 | 0.086 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.203025e-01 | 0.086 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.217153e-01 | 0.085 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.217153e-01 | 0.085 |
| R-HSA-9664407 | Parasite infection | 8.217153e-01 | 0.085 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.236723e-01 | 0.084 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.294161e-01 | 0.081 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.312890e-01 | 0.080 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.331528e-01 | 0.079 |
| R-HSA-166520 | Signaling by NTRKs | 8.385786e-01 | 0.076 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.402988e-01 | 0.076 |
| R-HSA-73887 | Death Receptor Signaling | 8.489297e-01 | 0.071 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.554610e-01 | 0.068 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.647352e-01 | 0.063 |
| R-HSA-5619102 | SLC transporter disorders | 8.691480e-01 | 0.061 |
| R-HSA-72306 | tRNA processing | 8.748097e-01 | 0.058 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.761866e-01 | 0.057 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.802278e-01 | 0.055 |
| R-HSA-3781865 | Diseases of glycosylation | 8.927744e-01 | 0.049 |
| R-HSA-6798695 | Neutrophil degranulation | 8.965522e-01 | 0.047 |
| R-HSA-1474244 | Extracellular matrix organization | 8.982320e-01 | 0.047 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.027656e-01 | 0.044 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.029444e-01 | 0.044 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.068804e-01 | 0.042 |
| R-HSA-1643685 | Disease | 9.395644e-01 | 0.027 |
| R-HSA-15869 | Metabolism of nucleotides | 9.404219e-01 | 0.027 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.410799e-01 | 0.026 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.626547e-01 | 0.017 |
| R-HSA-168249 | Innate Immune System | 9.636267e-01 | 0.016 |
| R-HSA-9658195 | Leishmania infection | 9.638818e-01 | 0.016 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.638818e-01 | 0.016 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.669615e-01 | 0.015 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.676379e-01 | 0.014 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.694412e-01 | 0.013 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.710075e-01 | 0.013 |
| R-HSA-5683057 | MAPK family signaling cascades | 9.827094e-01 | 0.008 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.902348e-01 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 9.912716e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.912716e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.930282e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.933520e-01 | 0.003 |
| R-HSA-211859 | Biological oxidations | 9.976385e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.990112e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.998651e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999482e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999904e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.773 | 0.258 | 1 | 0.846 |
HIPK4 |
0.757 | 0.258 | 1 | 0.820 |
CLK2 |
0.755 | 0.203 | -3 | 0.731 |
SRPK1 |
0.753 | 0.183 | -3 | 0.742 |
KIS |
0.753 | 0.190 | 1 | 0.794 |
COT |
0.749 | 0.123 | 2 | 0.799 |
HIPK2 |
0.749 | 0.240 | 1 | 0.759 |
DYRK2 |
0.749 | 0.237 | 1 | 0.815 |
CDK18 |
0.748 | 0.236 | 1 | 0.747 |
CDK19 |
0.747 | 0.231 | 1 | 0.760 |
CDKL5 |
0.744 | 0.185 | -3 | 0.760 |
CDC7 |
0.743 | 0.128 | 1 | 0.781 |
P38B |
0.743 | 0.260 | 1 | 0.785 |
PRKD1 |
0.743 | 0.200 | -3 | 0.805 |
CDK1 |
0.743 | 0.204 | 1 | 0.776 |
JNK2 |
0.742 | 0.239 | 1 | 0.756 |
ERK5 |
0.742 | 0.196 | 1 | 0.856 |
MOS |
0.742 | 0.149 | 1 | 0.791 |
CDK8 |
0.742 | 0.211 | 1 | 0.780 |
DYRK4 |
0.741 | 0.227 | 1 | 0.772 |
NDR2 |
0.741 | 0.094 | -3 | 0.818 |
PIM3 |
0.739 | 0.094 | -3 | 0.813 |
P38D |
0.738 | 0.243 | 1 | 0.725 |
P38A |
0.738 | 0.244 | 1 | 0.821 |
CDK7 |
0.738 | 0.202 | 1 | 0.794 |
MAK |
0.738 | 0.272 | -2 | 0.798 |
ERK1 |
0.737 | 0.224 | 1 | 0.773 |
NLK |
0.737 | 0.160 | 1 | 0.835 |
JNK3 |
0.736 | 0.222 | 1 | 0.776 |
ICK |
0.736 | 0.193 | -3 | 0.810 |
CDK5 |
0.736 | 0.214 | 1 | 0.808 |
CDK3 |
0.736 | 0.199 | 1 | 0.731 |
HIPK1 |
0.736 | 0.202 | 1 | 0.813 |
P38G |
0.735 | 0.212 | 1 | 0.710 |
CDKL1 |
0.735 | 0.124 | -3 | 0.769 |
SKMLCK |
0.735 | 0.138 | -2 | 0.718 |
MTOR |
0.733 | 0.072 | 1 | 0.716 |
CLK1 |
0.733 | 0.137 | -3 | 0.719 |
CDK17 |
0.732 | 0.201 | 1 | 0.711 |
SRPK2 |
0.732 | 0.106 | -3 | 0.658 |
CLK4 |
0.732 | 0.122 | -3 | 0.738 |
GRK1 |
0.731 | 0.075 | -2 | 0.629 |
RSK2 |
0.730 | 0.063 | -3 | 0.747 |
CDK13 |
0.729 | 0.177 | 1 | 0.772 |
BMPR1B |
0.729 | 0.117 | 1 | 0.767 |
PRPK |
0.727 | 0.050 | -1 | 0.729 |
CDK16 |
0.727 | 0.202 | 1 | 0.722 |
SRPK3 |
0.726 | 0.092 | -3 | 0.708 |
PRKD2 |
0.726 | 0.083 | -3 | 0.745 |
ATR |
0.726 | 0.044 | 1 | 0.737 |
AURC |
0.726 | 0.074 | -2 | 0.510 |
P90RSK |
0.725 | 0.054 | -3 | 0.749 |
CDK10 |
0.725 | 0.174 | 1 | 0.765 |
DYRK1A |
0.724 | 0.187 | 1 | 0.805 |
CHAK2 |
0.724 | 0.084 | -1 | 0.706 |
CDK12 |
0.724 | 0.175 | 1 | 0.753 |
PIM1 |
0.723 | 0.054 | -3 | 0.759 |
HIPK3 |
0.722 | 0.187 | 1 | 0.796 |
DYRK1B |
0.722 | 0.170 | 1 | 0.785 |
MAPKAPK2 |
0.722 | 0.039 | -3 | 0.708 |
CDK14 |
0.722 | 0.177 | 1 | 0.769 |
NDR1 |
0.722 | 0.008 | -3 | 0.797 |
RSK3 |
0.722 | 0.048 | -3 | 0.736 |
LATS2 |
0.721 | 0.010 | -5 | 0.211 |
IKKB |
0.721 | -0.039 | -2 | 0.557 |
NUAK2 |
0.720 | 0.024 | -3 | 0.799 |
CDK9 |
0.720 | 0.165 | 1 | 0.774 |
JNK1 |
0.719 | 0.186 | 1 | 0.746 |
LATS1 |
0.719 | 0.081 | -3 | 0.827 |
WNK1 |
0.719 | 0.020 | -2 | 0.721 |
GRK5 |
0.719 | -0.017 | -3 | 0.808 |
CAMK1B |
0.719 | -0.011 | -3 | 0.811 |
RSK4 |
0.718 | 0.052 | -3 | 0.729 |
RAF1 |
0.718 | -0.050 | 1 | 0.716 |
CAMK2A |
0.718 | 0.051 | 2 | 0.741 |
CAMK2D |
0.717 | 0.029 | -3 | 0.782 |
DSTYK |
0.717 | -0.017 | 2 | 0.825 |
BMPR2 |
0.717 | -0.023 | -2 | 0.686 |
MST4 |
0.717 | 0.032 | 2 | 0.791 |
GRK7 |
0.717 | 0.037 | 1 | 0.689 |
MAPKAPK3 |
0.716 | 0.011 | -3 | 0.736 |
TBK1 |
0.716 | -0.019 | 1 | 0.599 |
DYRK3 |
0.716 | 0.137 | 1 | 0.805 |
MLK2 |
0.716 | 0.120 | 2 | 0.726 |
GSK3A |
0.716 | 0.124 | 4 | 0.517 |
RIPK3 |
0.716 | 0.002 | 3 | 0.678 |
GCN2 |
0.715 | -0.068 | 2 | 0.702 |
CAMLCK |
0.715 | 0.024 | -2 | 0.670 |
IKKE |
0.715 | -0.008 | 1 | 0.596 |
MARK4 |
0.715 | 0.057 | 4 | 0.724 |
PDHK4 |
0.715 | -0.097 | 1 | 0.737 |
DAPK2 |
0.715 | 0.040 | -3 | 0.815 |
MPSK1 |
0.715 | 0.202 | 1 | 0.708 |
MLK1 |
0.714 | -0.012 | 2 | 0.739 |
PKN2 |
0.714 | 0.008 | -3 | 0.790 |
IKKA |
0.714 | 0.007 | -2 | 0.570 |
TGFBR2 |
0.714 | -0.023 | -2 | 0.621 |
NIK |
0.713 | -0.005 | -3 | 0.823 |
PKN3 |
0.713 | -0.002 | -3 | 0.777 |
PKACB |
0.713 | 0.051 | -2 | 0.506 |
MLK3 |
0.713 | 0.051 | 2 | 0.683 |
PKCB |
0.712 | 0.067 | 2 | 0.677 |
NEK6 |
0.712 | -0.011 | -2 | 0.669 |
PKCD |
0.712 | 0.034 | 2 | 0.705 |
ERK2 |
0.712 | 0.149 | 1 | 0.785 |
MOK |
0.712 | 0.195 | 1 | 0.830 |
CAMK2G |
0.711 | -0.061 | 2 | 0.724 |
PKACG |
0.711 | 0.006 | -2 | 0.554 |
GRK6 |
0.710 | -0.024 | 1 | 0.742 |
CK1E |
0.710 | 0.057 | -3 | 0.616 |
TGFBR1 |
0.709 | 0.041 | -2 | 0.649 |
MASTL |
0.709 | -0.013 | -2 | 0.637 |
TSSK2 |
0.709 | 0.041 | -5 | 0.297 |
CDK2 |
0.708 | 0.106 | 1 | 0.804 |
PKCG |
0.708 | 0.040 | 2 | 0.679 |
PRP4 |
0.708 | 0.104 | -3 | 0.739 |
ULK2 |
0.708 | -0.044 | 2 | 0.667 |
PASK |
0.707 | 0.090 | -3 | 0.839 |
HUNK |
0.707 | -0.017 | 2 | 0.756 |
PKCA |
0.707 | 0.045 | 2 | 0.658 |
CAMK2B |
0.707 | 0.003 | 2 | 0.699 |
PAK1 |
0.707 | 0.036 | -2 | 0.633 |
MSK1 |
0.706 | 0.034 | -3 | 0.715 |
TSSK1 |
0.706 | 0.036 | -3 | 0.822 |
AKT2 |
0.706 | 0.045 | -3 | 0.667 |
PRKX |
0.706 | 0.039 | -3 | 0.670 |
AMPKA1 |
0.706 | -0.011 | -3 | 0.805 |
FAM20C |
0.705 | 0.010 | 2 | 0.541 |
PDHK1 |
0.705 | -0.134 | 1 | 0.705 |
PRKD3 |
0.705 | 0.022 | -3 | 0.724 |
P70S6KB |
0.705 | -0.024 | -3 | 0.746 |
MNK2 |
0.705 | 0.024 | -2 | 0.612 |
ALK4 |
0.705 | 0.007 | -2 | 0.665 |
MNK1 |
0.704 | 0.035 | -2 | 0.607 |
SMG1 |
0.704 | 0.016 | 1 | 0.688 |
IRE1 |
0.704 | -0.010 | 1 | 0.677 |
GRK4 |
0.704 | -0.067 | -2 | 0.643 |
GSK3B |
0.703 | 0.078 | 4 | 0.514 |
NEK7 |
0.703 | -0.110 | -3 | 0.789 |
ACVR2B |
0.703 | 0.009 | -2 | 0.615 |
PKCZ |
0.703 | 0.032 | 2 | 0.688 |
MSK2 |
0.703 | 0.004 | -3 | 0.726 |
QSK |
0.703 | 0.040 | 4 | 0.699 |
PKG2 |
0.702 | 0.030 | -2 | 0.499 |
ATM |
0.702 | -0.020 | 1 | 0.688 |
NIM1 |
0.702 | 0.019 | 3 | 0.703 |
AMPKA2 |
0.702 | -0.002 | -3 | 0.776 |
MYLK4 |
0.701 | -0.002 | -2 | 0.602 |
ERK7 |
0.701 | 0.082 | 2 | 0.495 |
YSK4 |
0.701 | 0.007 | 1 | 0.636 |
TLK2 |
0.701 | 0.015 | 1 | 0.692 |
NEK9 |
0.701 | -0.042 | 2 | 0.739 |
CDK6 |
0.701 | 0.161 | 1 | 0.753 |
PAK3 |
0.701 | 0.015 | -2 | 0.617 |
PAK6 |
0.700 | 0.050 | -2 | 0.546 |
SGK3 |
0.700 | 0.031 | -3 | 0.727 |
DLK |
0.700 | -0.105 | 1 | 0.707 |
DNAPK |
0.700 | 0.021 | 1 | 0.616 |
BMPR1A |
0.700 | 0.035 | 1 | 0.739 |
ALK2 |
0.699 | 0.010 | -2 | 0.650 |
MST3 |
0.699 | 0.068 | 2 | 0.796 |
ACVR2A |
0.699 | -0.009 | -2 | 0.604 |
VRK2 |
0.699 | 0.034 | 1 | 0.770 |
BCKDK |
0.699 | -0.100 | -1 | 0.648 |
PKR |
0.699 | 0.004 | 1 | 0.721 |
AURB |
0.698 | 0.004 | -2 | 0.500 |
PIM2 |
0.698 | 0.010 | -3 | 0.707 |
DCAMKL1 |
0.698 | 0.028 | -3 | 0.758 |
GRK2 |
0.698 | -0.023 | -2 | 0.564 |
CHK1 |
0.697 | -0.011 | -3 | 0.757 |
MLK4 |
0.697 | -0.021 | 2 | 0.641 |
CK1D |
0.697 | 0.032 | -3 | 0.569 |
ANKRD3 |
0.697 | -0.110 | 1 | 0.726 |
MEK1 |
0.696 | -0.051 | 2 | 0.757 |
CDK4 |
0.696 | 0.158 | 1 | 0.743 |
TTBK2 |
0.696 | -0.086 | 2 | 0.624 |
PKCH |
0.696 | 0.007 | 2 | 0.645 |
PHKG1 |
0.696 | -0.024 | -3 | 0.786 |
MARK3 |
0.696 | 0.022 | 4 | 0.650 |
AURA |
0.695 | -0.002 | -2 | 0.488 |
ULK1 |
0.694 | -0.107 | -3 | 0.737 |
CK1G1 |
0.694 | 0.028 | -3 | 0.611 |
RIPK1 |
0.694 | -0.133 | 1 | 0.680 |
PKACA |
0.693 | 0.025 | -2 | 0.468 |
CK1A2 |
0.693 | 0.025 | -3 | 0.569 |
IRE2 |
0.692 | -0.032 | 2 | 0.638 |
NUAK1 |
0.691 | -0.039 | -3 | 0.739 |
QIK |
0.691 | -0.057 | -3 | 0.775 |
DRAK1 |
0.691 | -0.019 | 1 | 0.681 |
GRK3 |
0.691 | -0.014 | -2 | 0.535 |
BRSK1 |
0.691 | -0.008 | -3 | 0.751 |
TAO3 |
0.690 | 0.017 | 1 | 0.669 |
SIK |
0.690 | -0.011 | -3 | 0.716 |
WNK3 |
0.690 | -0.183 | 1 | 0.678 |
NEK2 |
0.689 | -0.023 | 2 | 0.720 |
MELK |
0.689 | -0.042 | -3 | 0.752 |
PKCE |
0.689 | 0.034 | 2 | 0.669 |
CHAK1 |
0.689 | -0.055 | 2 | 0.665 |
CAMK4 |
0.688 | -0.117 | -3 | 0.767 |
GAK |
0.688 | 0.037 | 1 | 0.759 |
AKT3 |
0.687 | 0.045 | -3 | 0.624 |
PAK2 |
0.687 | -0.042 | -2 | 0.609 |
SSTK |
0.687 | 0.076 | 4 | 0.679 |
BRSK2 |
0.687 | -0.034 | -3 | 0.759 |
PLK1 |
0.686 | -0.092 | -2 | 0.579 |
GCK |
0.686 | 0.029 | 1 | 0.697 |
MEKK2 |
0.686 | -0.038 | 2 | 0.703 |
AKT1 |
0.685 | 0.010 | -3 | 0.682 |
TLK1 |
0.685 | -0.074 | -2 | 0.660 |
MARK2 |
0.685 | -0.017 | 4 | 0.616 |
MEK5 |
0.685 | -0.109 | 2 | 0.725 |
NEK5 |
0.685 | -0.019 | 1 | 0.707 |
BUB1 |
0.684 | 0.041 | -5 | 0.203 |
PERK |
0.684 | -0.073 | -2 | 0.641 |
WNK4 |
0.683 | -0.054 | -2 | 0.723 |
MEKK3 |
0.683 | -0.121 | 1 | 0.679 |
MAPKAPK5 |
0.682 | -0.066 | -3 | 0.664 |
PKCT |
0.682 | -0.005 | 2 | 0.643 |
HPK1 |
0.682 | 0.028 | 1 | 0.677 |
SBK |
0.682 | 0.039 | -3 | 0.556 |
PKCI |
0.682 | -0.014 | 2 | 0.666 |
SMMLCK |
0.681 | -0.046 | -3 | 0.769 |
TNIK |
0.681 | 0.077 | 3 | 0.833 |
CK2A2 |
0.681 | 0.002 | 1 | 0.660 |
PINK1 |
0.681 | -0.072 | 1 | 0.783 |
DCAMKL2 |
0.681 | -0.039 | -3 | 0.769 |
EEF2K |
0.681 | 0.036 | 3 | 0.786 |
DAPK3 |
0.681 | 0.002 | -3 | 0.769 |
PLK3 |
0.681 | -0.084 | 2 | 0.690 |
MEKK1 |
0.681 | -0.090 | 1 | 0.673 |
SGK1 |
0.681 | 0.025 | -3 | 0.597 |
PAK4 |
0.680 | 0.023 | -2 | 0.521 |
ZAK |
0.680 | -0.085 | 1 | 0.632 |
CAMK1G |
0.680 | -0.067 | -3 | 0.713 |
NEK11 |
0.679 | -0.056 | 1 | 0.667 |
PLK4 |
0.679 | -0.059 | 2 | 0.516 |
KHS1 |
0.679 | 0.080 | 1 | 0.659 |
PDK1 |
0.679 | -0.011 | 1 | 0.670 |
DAPK1 |
0.679 | 0.004 | -3 | 0.755 |
HGK |
0.678 | 0.043 | 3 | 0.829 |
LKB1 |
0.678 | 0.011 | -3 | 0.771 |
MARK1 |
0.677 | -0.047 | 4 | 0.660 |
HRI |
0.677 | -0.121 | -2 | 0.654 |
IRAK4 |
0.677 | -0.052 | 1 | 0.668 |
BRAF |
0.677 | -0.096 | -4 | 0.691 |
ROCK2 |
0.677 | 0.024 | -3 | 0.751 |
PAK5 |
0.677 | -0.006 | -2 | 0.506 |
KHS2 |
0.676 | 0.043 | 1 | 0.678 |
PBK |
0.676 | 0.065 | 1 | 0.698 |
MEKK6 |
0.676 | 0.024 | 1 | 0.684 |
MINK |
0.676 | 0.021 | 1 | 0.663 |
MST2 |
0.676 | -0.041 | 1 | 0.692 |
CK2A1 |
0.675 | 0.007 | 1 | 0.636 |
MAP3K15 |
0.675 | 0.014 | 1 | 0.621 |
TAO2 |
0.675 | -0.041 | 2 | 0.758 |
CAMKK2 |
0.674 | -0.029 | -2 | 0.576 |
SNRK |
0.673 | -0.114 | 2 | 0.548 |
TAK1 |
0.673 | -0.037 | 1 | 0.706 |
P70S6K |
0.673 | -0.062 | -3 | 0.657 |
LRRK2 |
0.672 | -0.030 | 2 | 0.747 |
PKN1 |
0.672 | -0.017 | -3 | 0.680 |
MRCKB |
0.672 | -0.001 | -3 | 0.695 |
CAMKK1 |
0.671 | -0.070 | -2 | 0.566 |
CAMK1D |
0.671 | -0.052 | -3 | 0.656 |
DMPK1 |
0.669 | 0.012 | -3 | 0.731 |
CK1A |
0.669 | 0.018 | -3 | 0.494 |
MRCKA |
0.669 | -0.023 | -3 | 0.710 |
PHKG2 |
0.669 | -0.066 | -3 | 0.747 |
PLK2 |
0.668 | -0.041 | -3 | 0.749 |
NEK4 |
0.668 | -0.073 | 1 | 0.657 |
SLK |
0.667 | -0.041 | -2 | 0.529 |
CHK2 |
0.667 | -0.048 | -3 | 0.618 |
LOK |
0.667 | -0.025 | -2 | 0.565 |
NEK8 |
0.666 | -0.145 | 2 | 0.721 |
NEK1 |
0.666 | -0.043 | 1 | 0.662 |
VRK1 |
0.666 | -0.039 | 2 | 0.751 |
HASPIN |
0.664 | 0.005 | -1 | 0.584 |
TTBK1 |
0.664 | -0.133 | 2 | 0.546 |
MST1 |
0.663 | -0.069 | 1 | 0.660 |
YSK1 |
0.661 | -0.014 | 2 | 0.722 |
PDHK3_TYR |
0.660 | 0.246 | 4 | 0.806 |
CAMK1A |
0.660 | -0.056 | -3 | 0.642 |
YANK3 |
0.659 | -0.021 | 2 | 0.363 |
CRIK |
0.658 | -0.020 | -3 | 0.684 |
OSR1 |
0.658 | -0.029 | 2 | 0.702 |
IRAK1 |
0.657 | -0.185 | -1 | 0.594 |
ROCK1 |
0.657 | -0.012 | -3 | 0.708 |
STK33 |
0.656 | -0.091 | 2 | 0.531 |
MYO3B |
0.654 | 0.004 | 2 | 0.736 |
BIKE |
0.652 | -0.006 | 1 | 0.663 |
MEK2 |
0.652 | -0.130 | 2 | 0.703 |
AAK1 |
0.651 | 0.036 | 1 | 0.589 |
MAP2K6_TYR |
0.650 | 0.094 | -1 | 0.742 |
TTK |
0.650 | -0.079 | -2 | 0.624 |
PKMYT1_TYR |
0.649 | 0.144 | 3 | 0.801 |
MAP2K4_TYR |
0.649 | 0.102 | -1 | 0.740 |
PKG1 |
0.648 | -0.033 | -2 | 0.411 |
ASK1 |
0.647 | -0.045 | 1 | 0.603 |
PDHK4_TYR |
0.647 | 0.029 | 2 | 0.786 |
MYO3A |
0.647 | -0.033 | 1 | 0.653 |
LIMK2_TYR |
0.646 | 0.115 | -3 | 0.828 |
NEK3 |
0.645 | -0.090 | 1 | 0.623 |
TESK1_TYR |
0.644 | 0.026 | 3 | 0.822 |
EPHA6 |
0.643 | 0.129 | -1 | 0.688 |
BMPR2_TYR |
0.643 | 0.009 | -1 | 0.732 |
PDHK1_TYR |
0.643 | 0.006 | -1 | 0.736 |
TAO1 |
0.642 | -0.061 | 1 | 0.585 |
RIPK2 |
0.641 | -0.197 | 1 | 0.586 |
ALPHAK3 |
0.641 | -0.101 | -1 | 0.622 |
TXK |
0.638 | 0.080 | 1 | 0.760 |
MAP2K7_TYR |
0.638 | -0.060 | 2 | 0.759 |
EPHB4 |
0.635 | 0.050 | -1 | 0.655 |
FGR |
0.632 | 0.007 | 1 | 0.758 |
ABL2 |
0.631 | 0.043 | -1 | 0.637 |
TNK2 |
0.631 | 0.054 | 3 | 0.697 |
LCK |
0.630 | 0.029 | -1 | 0.690 |
PINK1_TYR |
0.629 | -0.142 | 1 | 0.724 |
LIMK1_TYR |
0.629 | -0.053 | 2 | 0.739 |
ABL1 |
0.629 | 0.043 | -1 | 0.630 |
BLK |
0.628 | 0.035 | -1 | 0.688 |
YANK2 |
0.627 | -0.041 | 2 | 0.373 |
CK1G3 |
0.627 | -0.034 | -3 | 0.453 |
EPHA4 |
0.627 | 0.009 | 2 | 0.715 |
YES1 |
0.627 | -0.025 | -1 | 0.710 |
CK1G2 |
0.627 | -0.029 | -3 | 0.536 |
ITK |
0.627 | 0.008 | -1 | 0.636 |
CSF1R |
0.626 | -0.011 | 3 | 0.731 |
TYRO3 |
0.625 | -0.051 | 3 | 0.735 |
ROS1 |
0.624 | -0.012 | 3 | 0.697 |
RET |
0.624 | -0.069 | 1 | 0.669 |
HCK |
0.624 | -0.013 | -1 | 0.685 |
FYN |
0.624 | 0.021 | -1 | 0.683 |
SRMS |
0.623 | -0.008 | 1 | 0.764 |
STLK3 |
0.623 | -0.139 | 1 | 0.600 |
DDR1 |
0.623 | -0.043 | 4 | 0.704 |
MST1R |
0.621 | -0.084 | 3 | 0.750 |
BMX |
0.621 | 0.002 | -1 | 0.571 |
JAK2 |
0.621 | -0.056 | 1 | 0.665 |
FER |
0.620 | -0.064 | 1 | 0.785 |
TNNI3K_TYR |
0.619 | 0.024 | 1 | 0.695 |
EPHB1 |
0.619 | -0.038 | 1 | 0.755 |
EPHB3 |
0.619 | -0.016 | -1 | 0.636 |
EPHB2 |
0.618 | -0.015 | -1 | 0.624 |
INSRR |
0.617 | -0.071 | 3 | 0.664 |
JAK3 |
0.617 | -0.071 | 1 | 0.650 |
MERTK |
0.616 | -0.016 | 3 | 0.703 |
TYK2 |
0.616 | -0.141 | 1 | 0.666 |
KIT |
0.615 | -0.067 | 3 | 0.733 |
MET |
0.615 | -0.040 | 3 | 0.723 |
TNK1 |
0.615 | -0.014 | 3 | 0.730 |
PTK2 |
0.614 | 0.015 | -1 | 0.656 |
EPHA7 |
0.613 | -0.016 | 2 | 0.694 |
JAK1 |
0.613 | -0.025 | 1 | 0.603 |
KDR |
0.612 | -0.084 | 3 | 0.685 |
PTK2B |
0.611 | -0.002 | -1 | 0.604 |
TEC |
0.611 | -0.062 | -1 | 0.565 |
LYN |
0.610 | -0.036 | 3 | 0.668 |
SYK |
0.610 | -0.006 | -1 | 0.631 |
FGFR2 |
0.609 | -0.109 | 3 | 0.716 |
SRC |
0.609 | -0.033 | -1 | 0.672 |
DDR2 |
0.609 | -0.005 | 3 | 0.648 |
NEK10_TYR |
0.607 | -0.075 | 1 | 0.548 |
FRK |
0.607 | -0.044 | -1 | 0.668 |
WEE1_TYR |
0.607 | -0.075 | -1 | 0.595 |
EPHA3 |
0.607 | -0.072 | 2 | 0.668 |
FLT1 |
0.606 | -0.094 | -1 | 0.655 |
BTK |
0.606 | -0.107 | -1 | 0.608 |
EPHA1 |
0.606 | -0.036 | 3 | 0.700 |
AXL |
0.606 | -0.090 | 3 | 0.694 |
TEK |
0.606 | -0.121 | 3 | 0.666 |
EPHA8 |
0.604 | -0.041 | -1 | 0.628 |
EPHA5 |
0.602 | -0.055 | 2 | 0.684 |
LTK |
0.602 | -0.087 | 3 | 0.666 |
PTK6 |
0.602 | -0.122 | -1 | 0.572 |
MATK |
0.602 | -0.074 | -1 | 0.557 |
ALK |
0.601 | -0.095 | 3 | 0.637 |
FGFR1 |
0.601 | -0.112 | 3 | 0.680 |
PDGFRB |
0.601 | -0.170 | 3 | 0.733 |
FLT3 |
0.601 | -0.152 | 3 | 0.743 |
FGFR3 |
0.601 | -0.109 | 3 | 0.685 |
CSK |
0.599 | -0.060 | 2 | 0.695 |
INSR |
0.598 | -0.097 | 3 | 0.657 |
NTRK3 |
0.597 | -0.082 | -1 | 0.611 |
ERBB2 |
0.597 | -0.138 | 1 | 0.629 |
PDGFRA |
0.597 | -0.168 | 3 | 0.737 |
NTRK1 |
0.597 | -0.161 | -1 | 0.646 |
ZAP70 |
0.596 | -0.008 | -1 | 0.574 |
EPHA2 |
0.595 | -0.043 | -1 | 0.599 |
ERBB4 |
0.595 | -0.032 | 1 | 0.599 |
EGFR |
0.594 | -0.079 | 1 | 0.544 |
FGFR4 |
0.591 | -0.086 | -1 | 0.593 |
FLT4 |
0.591 | -0.167 | 3 | 0.683 |
NTRK2 |
0.588 | -0.188 | 3 | 0.672 |
IGF1R |
0.582 | -0.122 | 3 | 0.596 |
MUSK |
0.580 | -0.102 | 1 | 0.543 |
FES |
0.579 | -0.082 | -1 | 0.544 |