Motif 311 (n=146)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S537 | ochoa | Golgin A8 family member Q | None |
| A0A0J9YX86 | GOLGA8Q | S553 | ochoa | Golgin A8 family member Q | None |
| A6NMD2 | GOLGA8J | S537 | ochoa | Golgin subfamily A member 8J | None |
| A6NMD2 | GOLGA8J | S553 | ochoa | Golgin subfamily A member 8J | None |
| C9JI98 | TMEM238 | S154 | ochoa | Transmembrane protein 238 | None |
| H3BQL2 | GOLGA8T | S536 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S537 | ochoa | Golgin subfamily A member 8M | None |
| H3BSY2 | GOLGA8M | S553 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S536 | ochoa | Golgin subfamily A member 8R | None |
| I6L899 | GOLGA8R | S552 | ochoa | Golgin subfamily A member 8R | None |
| O14640 | DVL1 | S604 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14654 | IRS4 | S1185 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15479 | MAGEB2 | S77 | ochoa | Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| O15479 | MAGEB2 | S78 | ochoa | Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| O15534 | PER1 | S1007 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43660 | PLRG1 | S119 | ochoa | Pleiotropic regulator 1 | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| O43707 | ACTN4 | S263 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60264 | SMARCA5 | S32 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60346 | PHLPP1 | S142 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S143 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S144 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O75069 | TMCC2 | S491 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75122 | CLASP2 | S368 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75676 | RPS6KA4 | S737 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O95180 | CACNA1H | S44 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95336 | PGLS | S46 | ochoa | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}. |
| O95396 | MOCS3 | S150 | ochoa | Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:19017811, PubMed:22453920, PubMed:30817134). Also essential during biosynthesis of the molybdenum cofactor (PubMed:15073332, PubMed:22453920, PubMed:30817134). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:15073332, PubMed:19017811, PubMed:22453920). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (PubMed:19017811, PubMed:22453920). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A (PubMed:15073332, PubMed:22453920). Subsequently, a transient disulfide bond is formed (PubMed:15073332, PubMed:22453920). Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions (PubMed:18650437, PubMed:22453920). {ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332, ECO:0000269|PubMed:18650437, ECO:0000269|PubMed:19017811, ECO:0000269|PubMed:22453920, ECO:0000269|PubMed:30817134}. |
| P05062 | ALDOB | S272 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P05387 | RPLP2 | S79 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P0CJ92 | GOLGA8H | S537 | ochoa | Golgin subfamily A member 8H | None |
| P0CJ92 | GOLGA8H | S553 | ochoa | Golgin subfamily A member 8H | None |
| P12814 | ACTN1 | S244 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P12931 | SRC | S43 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P14859 | POU2F1 | S141 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14859 | POU2F1 | S143 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P16989 | YBX3 | S34 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P19419 | ELK1 | S194 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P19419 | ELK1 | S196 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P19419 | ELK1 | S198 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P22736 | NR4A1 | S52 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P29966 | MARCKS | S63 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S77 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S83 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S101 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S118 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P35221 | CTNNA1 | S268 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35232 | PHB1 | S213 | ochoa | Prohibitin 1 | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:P67778, ECO:0000250|UniProtKB:P67779, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:P67778, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195). {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:31899195}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:P67778}. |
| P35568 | IRS1 | S1037 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S1041 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S1043 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P41250 | GARS1 | S53 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P46060 | RANGAP1 | S301 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P49716 | CEBPD | S57 | psp | CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) | Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16397300, PubMed:1741402). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). {ECO:0000269|PubMed:1741402}. |
| P52179 | MYOM1 | S69 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52701 | MSH6 | S43 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P53396 | ACLY | S444 | ochoa | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:39881208, ECO:0000269|PubMed:9116495}. |
| P54198 | HIRA | S533 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P58012 | FOXL2 | S323 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P61964 | WDR5 | S22 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| P80723 | BASP1 | S176 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| Q00839 | HNRNPU | S187 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q00839 | HNRNPU | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q01094 | E2F1 | S31 | psp | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:18625225, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:8170954}. |
| Q02447 | SP3 | S73 | ochoa|psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q02952 | AKAP12 | S885 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q06945 | SOX4 | S354 | ochoa | Transcription factor SOX-4 | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}. |
| Q08379 | GOLGA2 | S792 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
| Q12962 | TAF10 | T48 | ochoa | Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:12601814, PubMed:18206972, PubMed:9885574). May regulate cyclin E expression (By similarity). {ECO:0000250|UniProtKB:Q8K0H5, ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:12601814, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9885574}. |
| Q13263 | TRIM28 | S596 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13459 | MYO9B | S1329 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14761 | PTPRCAP | S172 | ochoa|psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q147X3 | NAA30 | S134 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q16643 | DBN1 | S416 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q16825 | PTPN21 | S492 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q3LXA3 | TKFC | S350 | ochoa | Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] | Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090). {ECO:0000250|UniProtKB:F1RKQ4, ECO:0000250|UniProtKB:Q4KLZ6, ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:17600090, ECO:0000269|PubMed:32004446, ECO:0000269|PubMed:4688871}. |
| Q5GH72 | XKR7 | S26 | ochoa | XK-related protein 7 | None |
| Q5JSZ5 | PRRC2B | S1508 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTC6 | AMER1 | S19 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T1J5 | CHCHD2P9 | S45 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q5T1J5 | CHCHD2P9 | S46 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q5T4S7 | UBR4 | S3342 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5VWG9 | TAF3 | S830 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q6DKI7 | PVRIG | S284 | ochoa | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}. |
| Q6L8Q7 | PDE12 | S98 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6NV74 | CRACDL | S520 | ochoa | CRACD-like protein | None |
| Q6XQN6 | NAPRT | Y21 | ochoa | Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}. |
| Q6ZN55 | ZNF574 | S723 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZRV2 | FAM83H | S761 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q7L311 | ARMCX2 | S238 | ochoa | Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) | May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. |
| Q7L311 | ARMCX2 | S244 | ochoa | Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) | May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. |
| Q7RTV3 | ZNF367 | S119 | ochoa | Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) | Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}. |
| Q7Z2K8 | GPRIN1 | S970 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3C6 | ATG9A | S759 | ochoa | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z5J4 | RAI1 | S636 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86V48 | LUZP1 | S575 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86XP3 | DDX42 | S717 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8N3D4 | EHBP1L1 | S993 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N5A5 | ZGPAT | S99 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N884 | CGAS | S64 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NAF0 | ZNF579 | S196 | ochoa | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q8NDF8 | TENT4B | S54 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8WZ75 | ROBO4 | S894 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q8WZ75 | ROBO4 | S895 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q8WZ75 | ROBO4 | S896 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q8WZ75 | ROBO4 | S899 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92766 | RREB1 | S1103 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92945 | KHSRP | Y583 | psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q969V6 | MRTFA | S416 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96B18 | DACT3 | S186 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96B18 | DACT3 | S188 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96PK6 | RBM14 | S256 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S521 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S523 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S555 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96T58 | SPEN | S1797 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99490 | AGAP2 | S634 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q9H4A3 | WNK1 | S31 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9H6Z4 | RANBP3 | S219 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H6Z4 | RANBP3 | S358 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H6Z4 | RANBP3 | S359 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H8Y8 | GORASP2 | S409 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9NQC3 | RTN4 | S184 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQT8 | KIF13B | S1797 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NZ56 | FMN2 | S320 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9UBP0 | SPAST | S92 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UBU6 | FAM8A1 | S83 | ochoa | Protein FAM8A1 (Autosomal highly conserved protein) | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}. |
| Q9UKK3 | PARP4 | S1340 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKL0 | RCOR1 | S47 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKL0 | RCOR1 | S52 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKL0 | RCOR1 | S53 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKY7 | CDV3 | S37 | ochoa | Protein CDV3 homolog | None |
| Q9ULT8 | HECTD1 | S251 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UNF1 | MAGED2 | S157 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UQ35 | SRRM2 | S2244 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2280 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2343 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2355 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2368 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2J2 | EPB41L3 | S873 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2Y9 | KLF13 | S123 | psp | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y490 | TLN1 | S992 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G8 | RAPGEF2 | S1225 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y4H2 | IRS2 | T363 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6H1 | CHCHD2 | S45 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| Q9Y6H1 | CHCHD2 | S46 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| P22102 | GART | S88 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-74713 | IRS activation | 0.001413 | 2.850 |
| R-HSA-68911 | G2 Phase | 0.001413 | 2.850 |
| R-HSA-112412 | SOS-mediated signalling | 0.002841 | 2.547 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.002841 | 2.547 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.002081 | 2.682 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.007733 | 2.112 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.006232 | 2.205 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.007925 | 2.101 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.007925 | 2.101 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.008841 | 2.053 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.008841 | 2.053 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.008841 | 2.053 |
| R-HSA-354192 | Integrin signaling | 0.003622 | 2.441 |
| R-HSA-198203 | PI3K/AKT activation | 0.004729 | 2.325 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.008406 | 2.075 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.008841 | 2.053 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.007925 | 2.101 |
| R-HSA-74749 | Signal attenuation | 0.004729 | 2.325 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.005693 | 2.245 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.005456 | 2.263 |
| R-HSA-69236 | G1 Phase | 0.007983 | 2.098 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.007983 | 2.098 |
| R-HSA-2586552 | Signaling by Leptin | 0.004729 | 2.325 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.010804 | 1.966 |
| R-HSA-70350 | Fructose catabolism | 0.010804 | 1.966 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.010804 | 1.966 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.010804 | 1.966 |
| R-HSA-166520 | Signaling by NTRKs | 0.009856 | 2.006 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.011830 | 1.927 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.011852 | 1.926 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.012942 | 1.888 |
| R-HSA-422475 | Axon guidance | 0.013094 | 1.883 |
| R-HSA-5657560 | Hereditary fructose intolerance | 0.015406 | 1.812 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.015406 | 1.812 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.016969 | 1.770 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.016462 | 1.784 |
| R-HSA-373753 | Nephrin family interactions | 0.016462 | 1.784 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.018962 | 1.722 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.019654 | 1.707 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.019010 | 1.721 |
| R-HSA-9675108 | Nervous system development | 0.019453 | 1.711 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.020015 | 1.699 |
| R-HSA-5652084 | Fructose metabolism | 0.020342 | 1.692 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.023021 | 1.638 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.022558 | 1.647 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.021712 | 1.663 |
| R-HSA-114608 | Platelet degranulation | 0.025288 | 1.597 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.024322 | 1.614 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.025858 | 1.587 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.026043 | 1.584 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.023344 | 1.632 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.024563 | 1.610 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.027559 | 1.560 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.027717 | 1.557 |
| R-HSA-9909396 | Circadian clock | 0.028818 | 1.540 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.029434 | 1.531 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.038075 | 1.419 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.038075 | 1.419 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.038075 | 1.419 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.036393 | 1.439 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.035643 | 1.448 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.039603 | 1.402 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.038075 | 1.419 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.032310 | 1.491 |
| R-HSA-1538133 | G0 and Early G1 | 0.035643 | 1.448 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.035643 | 1.448 |
| R-HSA-5673000 | RAF activation | 0.040879 | 1.389 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.039875 | 1.399 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.034082 | 1.467 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.037352 | 1.428 |
| R-HSA-5205647 | Mitophagy | 0.040879 | 1.389 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.042685 | 1.370 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.044520 | 1.351 |
| R-HSA-8853659 | RET signaling | 0.044520 | 1.351 |
| R-HSA-191650 | Regulation of gap junction activity | 0.045515 | 1.342 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.045515 | 1.342 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.046385 | 1.334 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.060226 | 1.220 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.060226 | 1.220 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.067496 | 1.171 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.088975 | 1.051 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.096025 | 1.018 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.103021 | 0.987 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.103021 | 0.987 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.103021 | 0.987 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.109963 | 0.959 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.109963 | 0.959 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.116852 | 0.932 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.116852 | 0.932 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.116852 | 0.932 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.116852 | 0.932 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.116852 | 0.932 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.116852 | 0.932 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.123688 | 0.908 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.137202 | 0.863 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.137202 | 0.863 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.143882 | 0.842 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.052145 | 1.283 |
| R-HSA-167161 | HIV Transcription Initiation | 0.056120 | 1.251 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.056120 | 1.251 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.195505 | 0.709 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.238134 | 0.623 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.110733 | 0.956 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.165904 | 0.780 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.165904 | 0.780 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.085049 | 1.070 |
| R-HSA-72172 | mRNA Splicing | 0.097714 | 1.010 |
| R-HSA-3928664 | Ephrin signaling | 0.163615 | 0.786 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.064373 | 1.191 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.278521 | 0.555 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.272884 | 0.564 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.116852 | 0.932 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.226188 | 0.646 |
| R-HSA-9609690 | HCMV Early Events | 0.234011 | 0.631 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.056120 | 1.251 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.060197 | 1.220 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.157088 | 0.804 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.137202 | 0.863 |
| R-HSA-9664420 | Killing mechanisms | 0.143882 | 0.842 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.143882 | 0.842 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.056120 | 1.251 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.056120 | 1.251 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.195505 | 0.709 |
| R-HSA-8949664 | Processing of SMDT1 | 0.123688 | 0.908 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.220146 | 0.657 |
| R-HSA-525793 | Myogenesis | 0.220146 | 0.657 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.261479 | 0.583 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.213340 | 0.671 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.123390 | 0.909 |
| R-HSA-9843745 | Adipogenesis | 0.107173 | 0.970 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.081871 | 1.087 |
| R-HSA-4839744 | Signaling by APC mutants | 0.103021 | 0.987 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.109963 | 0.959 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.207920 | 0.682 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.047916 | 1.320 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.203620 | 0.691 |
| R-HSA-9609646 | HCMV Infection | 0.159126 | 0.798 |
| R-HSA-112399 | IRS-mediated signalling | 0.091285 | 1.040 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.091285 | 1.040 |
| R-HSA-5358508 | Mismatch Repair | 0.163615 | 0.786 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.074711 | 1.127 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.096025 | 1.018 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.103021 | 0.987 |
| R-HSA-171007 | p38MAPK events | 0.137202 | 0.863 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.176518 | 0.753 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.108246 | 0.966 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.088975 | 1.051 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.130471 | 0.884 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.109963 | 0.959 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 0.189225 | 0.723 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.081985 | 1.086 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.244038 | 0.613 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.244038 | 0.613 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.264744 | 0.577 |
| R-HSA-9842663 | Signaling by LTK | 0.116852 | 0.932 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.189225 | 0.723 |
| R-HSA-373752 | Netrin-1 signaling | 0.062273 | 1.206 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.188016 | 0.726 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.207709 | 0.683 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.195505 | 0.709 |
| R-HSA-167172 | Transcription of the HIV genome | 0.118285 | 0.927 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.074711 | 1.127 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.074711 | 1.127 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.088975 | 1.051 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.170091 | 0.769 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.201736 | 0.695 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.149652 | 0.825 |
| R-HSA-68882 | Mitotic Anaphase | 0.277611 | 0.557 |
| R-HSA-195721 | Signaling by WNT | 0.234569 | 0.630 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.050197 | 1.299 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.088975 | 1.051 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.244038 | 0.613 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.202037 | 0.695 |
| R-HSA-68886 | M Phase | 0.204783 | 0.689 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.060226 | 1.220 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.060226 | 1.220 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.081871 | 1.087 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.088975 | 1.051 |
| R-HSA-167044 | Signalling to RAS | 0.182896 | 0.738 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.220146 | 0.657 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.241826 | 0.616 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.216175 | 0.665 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.133756 | 0.874 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.150510 | 0.822 |
| R-HSA-109704 | PI3K Cascade | 0.075219 | 1.124 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.128899 | 0.890 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.189225 | 0.723 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.261479 | 0.583 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.219014 | 0.660 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.081871 | 1.087 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.096025 | 1.018 |
| R-HSA-210990 | PECAM1 interactions | 0.103021 | 0.987 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.150510 | 0.822 |
| R-HSA-198753 | ERK/MAPK targets | 0.182896 | 0.738 |
| R-HSA-437239 | Recycling pathway of L1 | 0.068644 | 1.163 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.207920 | 0.682 |
| R-HSA-9620244 | Long-term potentiation | 0.214056 | 0.669 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.232184 | 0.634 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.238134 | 0.623 |
| R-HSA-8983711 | OAS antiviral response | 0.116852 | 0.932 |
| R-HSA-9930044 | Nuclear RNA decay | 0.261479 | 0.583 |
| R-HSA-3214847 | HATs acetylate histones | 0.210508 | 0.677 |
| R-HSA-1640170 | Cell Cycle | 0.058039 | 1.236 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.143882 | 0.842 |
| R-HSA-186763 | Downstream signal transduction | 0.249896 | 0.602 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.223257 | 0.651 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.123688 | 0.908 |
| R-HSA-162587 | HIV Life Cycle | 0.155714 | 0.808 |
| R-HSA-2559583 | Cellular Senescence | 0.201739 | 0.695 |
| R-HSA-1266738 | Developmental Biology | 0.264741 | 0.577 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.170091 | 0.769 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.220146 | 0.657 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.130471 | 0.884 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.137202 | 0.863 |
| R-HSA-9766229 | Degradation of CDH1 | 0.073005 | 1.137 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.095348 | 1.021 |
| R-HSA-201556 | Signaling by ALK | 0.050197 | 1.299 |
| R-HSA-162582 | Signal Transduction | 0.062882 | 1.201 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.137202 | 0.863 |
| R-HSA-180292 | GAB1 signalosome | 0.163615 | 0.786 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.170091 | 0.769 |
| R-HSA-381042 | PERK regulates gene expression | 0.278521 | 0.555 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.067205 | 1.173 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.103317 | 0.986 |
| R-HSA-1500931 | Cell-Cell communication | 0.121643 | 0.915 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.214056 | 0.669 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.232184 | 0.634 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.214056 | 0.669 |
| R-HSA-9733709 | Cardiogenesis | 0.261479 | 0.583 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.170091 | 0.769 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.232184 | 0.634 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.238134 | 0.623 |
| R-HSA-196807 | Nicotinate metabolism | 0.115754 | 0.936 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.272884 | 0.564 |
| R-HSA-3000170 | Syndecan interactions | 0.201736 | 0.695 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.261479 | 0.583 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.232184 | 0.634 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.238134 | 0.623 |
| R-HSA-187687 | Signalling to ERKs | 0.278521 | 0.555 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.150510 | 0.822 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.201736 | 0.695 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.182447 | 0.739 |
| R-HSA-392518 | Signal amplification | 0.272884 | 0.564 |
| R-HSA-1643685 | Disease | 0.107426 | 0.969 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.091285 | 1.040 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.207920 | 0.682 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.207920 | 0.682 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.253278 | 0.596 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.226188 | 0.646 |
| R-HSA-163685 | Integration of energy metabolism | 0.117011 | 0.932 |
| R-HSA-177929 | Signaling by EGFR | 0.088932 | 1.051 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.168643 | 0.773 |
| R-HSA-373760 | L1CAM interactions | 0.267611 | 0.572 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.276212 | 0.559 |
| R-HSA-9663891 | Selective autophagy | 0.174143 | 0.759 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.256144 | 0.592 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.226188 | 0.646 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.182447 | 0.739 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.168643 | 0.773 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.082839 | 1.082 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.122054 | 0.913 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.185229 | 0.732 |
| R-HSA-449147 | Signaling by Interleukins | 0.236944 | 0.625 |
| R-HSA-9824446 | Viral Infection Pathways | 0.278692 | 0.555 |
| R-HSA-68875 | Mitotic Prophase | 0.279078 | 0.554 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.279711 | 0.553 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.281943 | 0.550 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.284115 | 0.547 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.284115 | 0.547 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.284115 | 0.547 |
| R-HSA-109582 | Hemostasis | 0.288113 | 0.540 |
| R-HSA-4641258 | Degradation of DVL | 0.289665 | 0.538 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.289665 | 0.538 |
| R-HSA-419037 | NCAM1 interactions | 0.289665 | 0.538 |
| R-HSA-8875878 | MET promotes cell motility | 0.295173 | 0.530 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.295173 | 0.530 |
| R-HSA-194138 | Signaling by VEGF | 0.296255 | 0.528 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.300638 | 0.522 |
| R-HSA-71336 | Pentose phosphate pathway | 0.300638 | 0.522 |
| R-HSA-162906 | HIV Infection | 0.300785 | 0.522 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.306062 | 0.514 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.306062 | 0.514 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.306062 | 0.514 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.306062 | 0.514 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.306062 | 0.514 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.306062 | 0.514 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.307127 | 0.513 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.311443 | 0.507 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.311443 | 0.507 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.311443 | 0.507 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.315592 | 0.501 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.316784 | 0.499 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.316784 | 0.499 |
| R-HSA-8939211 | ESR-mediated signaling | 0.321945 | 0.492 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.322083 | 0.492 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.327341 | 0.485 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.327341 | 0.485 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.332559 | 0.478 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.332559 | 0.478 |
| R-HSA-774815 | Nucleosome assembly | 0.337737 | 0.471 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.337737 | 0.471 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.337737 | 0.471 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.342875 | 0.465 |
| R-HSA-9675135 | Diseases of DNA repair | 0.342875 | 0.465 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.344511 | 0.463 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.344511 | 0.463 |
| R-HSA-9664407 | Parasite infection | 0.344511 | 0.463 |
| R-HSA-1632852 | Macroautophagy | 0.347322 | 0.459 |
| R-HSA-4839726 | Chromatin organization | 0.347355 | 0.459 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.347973 | 0.458 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.347973 | 0.458 |
| R-HSA-5663205 | Infectious disease | 0.350328 | 0.456 |
| R-HSA-9634597 | GPER1 signaling | 0.353033 | 0.452 |
| R-HSA-70263 | Gluconeogenesis | 0.353033 | 0.452 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.353033 | 0.452 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.353033 | 0.452 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.358053 | 0.446 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.372883 | 0.428 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.372883 | 0.428 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.377750 | 0.423 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.377750 | 0.423 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.387373 | 0.412 |
| R-HSA-9612973 | Autophagy | 0.391689 | 0.407 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.392128 | 0.407 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.392128 | 0.407 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.392128 | 0.407 |
| R-HSA-9610379 | HCMV Late Events | 0.394420 | 0.404 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.402579 | 0.395 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.406177 | 0.391 |
| R-HSA-446728 | Cell junction organization | 0.408239 | 0.389 |
| R-HSA-983189 | Kinesins | 0.410788 | 0.386 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.410788 | 0.386 |
| R-HSA-379724 | tRNA Aminoacylation | 0.410788 | 0.386 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.410788 | 0.386 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.413377 | 0.384 |
| R-HSA-9658195 | Leishmania infection | 0.414457 | 0.383 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.414457 | 0.383 |
| R-HSA-450294 | MAP kinase activation | 0.415364 | 0.382 |
| R-HSA-2262752 | Cellular responses to stress | 0.416820 | 0.380 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.419521 | 0.377 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.419904 | 0.377 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.419904 | 0.377 |
| R-HSA-1268020 | Mitochondrial protein import | 0.419904 | 0.377 |
| R-HSA-186797 | Signaling by PDGF | 0.419904 | 0.377 |
| R-HSA-9707616 | Heme signaling | 0.419904 | 0.377 |
| R-HSA-373755 | Semaphorin interactions | 0.424409 | 0.372 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.437718 | 0.359 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.439945 | 0.357 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.439945 | 0.357 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.442086 | 0.354 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.442567 | 0.354 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.445181 | 0.351 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.445181 | 0.351 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.446420 | 0.350 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.446420 | 0.350 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.454989 | 0.342 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.454989 | 0.342 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.454989 | 0.342 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.454989 | 0.342 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.454989 | 0.342 |
| R-HSA-448424 | Interleukin-17 signaling | 0.454989 | 0.342 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.459223 | 0.338 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.459223 | 0.338 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.463426 | 0.334 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.463426 | 0.334 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.463426 | 0.334 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.467595 | 0.330 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.471733 | 0.326 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.475839 | 0.323 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.478542 | 0.320 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.479299 | 0.319 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.483956 | 0.315 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.487967 | 0.312 |
| R-HSA-4086400 | PCP/CE pathway | 0.487967 | 0.312 |
| R-HSA-68877 | Mitotic Prometaphase | 0.491048 | 0.309 |
| R-HSA-9659379 | Sensory processing of sound | 0.491948 | 0.308 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.495898 | 0.305 |
| R-HSA-6806834 | Signaling by MET | 0.495898 | 0.305 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.495898 | 0.305 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.495898 | 0.305 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.498462 | 0.302 |
| R-HSA-8953854 | Metabolism of RNA | 0.498868 | 0.302 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.498921 | 0.302 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.508241 | 0.294 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.515195 | 0.288 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.522707 | 0.282 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.523329 | 0.281 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.526419 | 0.279 |
| R-HSA-156902 | Peptide chain elongation | 0.530103 | 0.276 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.530103 | 0.276 |
| R-HSA-397014 | Muscle contraction | 0.539161 | 0.268 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.540985 | 0.267 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.544557 | 0.264 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.548101 | 0.261 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.548101 | 0.261 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.548101 | 0.261 |
| R-HSA-2029481 | FCGR activation | 0.551617 | 0.258 |
| R-HSA-418990 | Adherens junctions interactions | 0.552979 | 0.257 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.555107 | 0.256 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.558569 | 0.253 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.558569 | 0.253 |
| R-HSA-8951664 | Neddylation | 0.559779 | 0.252 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.562005 | 0.250 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.562005 | 0.250 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.562005 | 0.250 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.565414 | 0.248 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.565414 | 0.248 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.565414 | 0.248 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.568797 | 0.245 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.570949 | 0.243 |
| R-HSA-422356 | Regulation of insulin secretion | 0.572154 | 0.242 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.572154 | 0.242 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.572154 | 0.242 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.572154 | 0.242 |
| R-HSA-190236 | Signaling by FGFR | 0.572154 | 0.242 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.573394 | 0.242 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.575168 | 0.240 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.575485 | 0.240 |
| R-HSA-70171 | Glycolysis | 0.578790 | 0.237 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.582070 | 0.235 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.585324 | 0.233 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.585324 | 0.233 |
| R-HSA-1483255 | PI Metabolism | 0.585324 | 0.233 |
| R-HSA-192823 | Viral mRNA Translation | 0.588553 | 0.230 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.591757 | 0.228 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.591757 | 0.228 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.594937 | 0.226 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.594937 | 0.226 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.598092 | 0.223 |
| R-HSA-157118 | Signaling by NOTCH | 0.601136 | 0.221 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.601222 | 0.221 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.604329 | 0.219 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.604329 | 0.219 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.604329 | 0.219 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.607411 | 0.217 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.607411 | 0.217 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.607411 | 0.217 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.607411 | 0.217 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.610469 | 0.214 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.613504 | 0.212 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.613504 | 0.212 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.619504 | 0.208 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.619504 | 0.208 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.622469 | 0.206 |
| R-HSA-421270 | Cell-cell junction organization | 0.623725 | 0.205 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.631227 | 0.200 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.633665 | 0.198 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.636953 | 0.196 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.636953 | 0.196 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.637584 | 0.195 |
| R-HSA-70326 | Glucose metabolism | 0.639784 | 0.194 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.645378 | 0.190 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.645378 | 0.190 |
| R-HSA-73886 | Chromosome Maintenance | 0.650887 | 0.186 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.653609 | 0.185 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.653609 | 0.185 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.656310 | 0.183 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.658991 | 0.181 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.664289 | 0.178 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.664289 | 0.178 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.664289 | 0.178 |
| R-HSA-69206 | G1/S Transition | 0.664289 | 0.178 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.666908 | 0.176 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.682089 | 0.166 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.684680 | 0.165 |
| R-HSA-212436 | Generic Transcription Pathway | 0.686008 | 0.164 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.690449 | 0.161 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.696795 | 0.157 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.696795 | 0.157 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.701510 | 0.154 |
| R-HSA-6807070 | PTEN Regulation | 0.703841 | 0.153 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.708448 | 0.150 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.712984 | 0.147 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.718022 | 0.144 |
| R-HSA-6798695 | Neutrophil degranulation | 0.720673 | 0.142 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.724019 | 0.140 |
| R-HSA-69242 | S Phase | 0.726175 | 0.139 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.726175 | 0.139 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.730438 | 0.136 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.732544 | 0.135 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.734634 | 0.134 |
| R-HSA-9609507 | Protein localization | 0.736708 | 0.133 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.736708 | 0.133 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.738765 | 0.131 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.738765 | 0.131 |
| R-HSA-73887 | Death Receptor Signaling | 0.738765 | 0.131 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.740807 | 0.130 |
| R-HSA-9711097 | Cellular response to starvation | 0.746838 | 0.127 |
| R-HSA-109581 | Apoptosis | 0.754663 | 0.122 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.758485 | 0.120 |
| R-HSA-199991 | Membrane Trafficking | 0.767062 | 0.115 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.771403 | 0.113 |
| R-HSA-418555 | G alpha (s) signalling events | 0.773192 | 0.112 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.773192 | 0.112 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.774967 | 0.111 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.776727 | 0.110 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.776727 | 0.110 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.776727 | 0.110 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.783176 | 0.106 |
| R-HSA-74160 | Gene expression (Transcription) | 0.784918 | 0.105 |
| R-HSA-168255 | Influenza Infection | 0.787010 | 0.104 |
| R-HSA-73894 | DNA Repair | 0.796803 | 0.099 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.801558 | 0.096 |
| R-HSA-983712 | Ion channel transport | 0.803113 | 0.095 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.806185 | 0.094 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.819434 | 0.086 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.822254 | 0.085 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.823953 | 0.084 |
| R-HSA-5357801 | Programmed Cell Death | 0.827763 | 0.082 |
| R-HSA-9679506 | SARS-CoV Infections | 0.828270 | 0.082 |
| R-HSA-168249 | Innate Immune System | 0.831585 | 0.080 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.837000 | 0.077 |
| R-HSA-168256 | Immune System | 0.838381 | 0.077 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.856308 | 0.067 |
| R-HSA-72312 | rRNA processing | 0.860770 | 0.065 |
| R-HSA-15869 | Metabolism of nucleotides | 0.865093 | 0.063 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.866153 | 0.062 |
| R-HSA-72766 | Translation | 0.867108 | 0.062 |
| R-HSA-5688426 | Deubiquitination | 0.883880 | 0.054 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.889981 | 0.051 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.895215 | 0.048 |
| R-HSA-112316 | Neuronal System | 0.895906 | 0.048 |
| R-HSA-597592 | Post-translational protein modification | 0.914197 | 0.039 |
| R-HSA-1483257 | Phospholipid metabolism | 0.915367 | 0.038 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.932208 | 0.030 |
| R-HSA-1474244 | Extracellular matrix organization | 0.936377 | 0.029 |
| R-HSA-913531 | Interferon Signaling | 0.958251 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.960514 | 0.017 |
| R-HSA-418594 | G alpha (i) signalling events | 0.965518 | 0.015 |
| R-HSA-8978868 | Fatty acid metabolism | 0.965518 | 0.015 |
| R-HSA-1280218 | Adaptive Immune System | 0.969175 | 0.014 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.969407 | 0.013 |
| R-HSA-5668914 | Diseases of metabolism | 0.970604 | 0.013 |
| R-HSA-392499 | Metabolism of proteins | 0.973054 | 0.012 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.993663 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.996976 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998216 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999096 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999937 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999962 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999980 | 0.000 |
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| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.791 | 0.153 | 2 | 0.826 |
CLK3 |
0.787 | 0.139 | 1 | 0.747 |
PRKD1 |
0.783 | 0.169 | -3 | 0.697 |
HIPK4 |
0.782 | 0.157 | 1 | 0.732 |
ERK5 |
0.780 | 0.255 | 1 | 0.851 |
CDC7 |
0.779 | 0.069 | 1 | 0.712 |
MOS |
0.779 | 0.154 | 1 | 0.736 |
PIM3 |
0.777 | 0.062 | -3 | 0.678 |
NDR2 |
0.777 | 0.056 | -3 | 0.673 |
GRK1 |
0.776 | 0.147 | -2 | 0.689 |
SRPK1 |
0.775 | 0.090 | -3 | 0.639 |
MTOR |
0.775 | 0.071 | 1 | 0.669 |
KIS |
0.775 | 0.131 | 1 | 0.651 |
CDKL5 |
0.774 | 0.147 | -3 | 0.655 |
SKMLCK |
0.773 | 0.120 | -2 | 0.767 |
DYRK2 |
0.771 | 0.127 | 1 | 0.683 |
PRPK |
0.771 | 0.065 | -1 | 0.777 |
RSK2 |
0.770 | 0.056 | -3 | 0.630 |
CLK2 |
0.768 | 0.122 | -3 | 0.614 |
PRKD2 |
0.768 | 0.057 | -3 | 0.631 |
IKKB |
0.768 | -0.018 | -2 | 0.617 |
JNK2 |
0.767 | 0.157 | 1 | 0.596 |
HIPK2 |
0.767 | 0.136 | 1 | 0.611 |
CAMK1B |
0.767 | 0.022 | -3 | 0.695 |
CAMK2D |
0.767 | 0.059 | -3 | 0.673 |
ATR |
0.766 | 0.037 | 1 | 0.713 |
CDKL1 |
0.766 | 0.059 | -3 | 0.659 |
PIM1 |
0.766 | 0.042 | -3 | 0.633 |
AURC |
0.765 | 0.073 | -2 | 0.554 |
CAMK2G |
0.765 | 0.011 | 2 | 0.792 |
CDK8 |
0.765 | 0.094 | 1 | 0.623 |
CDK19 |
0.765 | 0.106 | 1 | 0.595 |
JNK3 |
0.765 | 0.144 | 1 | 0.629 |
P90RSK |
0.764 | 0.034 | -3 | 0.635 |
BMPR1B |
0.764 | 0.122 | 1 | 0.702 |
CAMK2A |
0.763 | 0.062 | 2 | 0.803 |
P38B |
0.763 | 0.158 | 1 | 0.664 |
MAPKAPK2 |
0.763 | 0.040 | -3 | 0.585 |
GRK7 |
0.763 | 0.116 | 1 | 0.650 |
NLK |
0.763 | 0.047 | 1 | 0.729 |
ICK |
0.763 | 0.092 | -3 | 0.690 |
MARK4 |
0.762 | 0.066 | 4 | 0.746 |
GRK5 |
0.762 | -0.002 | -3 | 0.699 |
CHAK2 |
0.762 | 0.059 | -1 | 0.741 |
HUNK |
0.761 | 0.044 | 2 | 0.776 |
NUAK2 |
0.761 | 0.012 | -3 | 0.678 |
RSK3 |
0.761 | 0.031 | -3 | 0.629 |
IKKA |
0.761 | 0.001 | -2 | 0.613 |
CAMK2B |
0.760 | 0.042 | 2 | 0.781 |
CDK18 |
0.760 | 0.120 | 1 | 0.596 |
DYRK4 |
0.760 | 0.123 | 1 | 0.619 |
DSTYK |
0.760 | -0.007 | 2 | 0.831 |
P38A |
0.760 | 0.148 | 1 | 0.710 |
CDK7 |
0.760 | 0.085 | 1 | 0.643 |
PDHK4 |
0.759 | -0.141 | 1 | 0.689 |
RAF1 |
0.759 | -0.091 | 1 | 0.660 |
NEK6 |
0.758 | 0.005 | -2 | 0.727 |
PKACB |
0.758 | 0.054 | -2 | 0.570 |
FAM20C |
0.758 | 0.048 | 2 | 0.580 |
P38G |
0.758 | 0.116 | 1 | 0.547 |
HIPK1 |
0.758 | 0.118 | 1 | 0.684 |
WNK1 |
0.757 | -0.001 | -2 | 0.792 |
NDR1 |
0.757 | -0.022 | -3 | 0.663 |
GRK6 |
0.757 | 0.019 | 1 | 0.684 |
BMPR2 |
0.757 | -0.089 | -2 | 0.744 |
MAPKAPK3 |
0.756 | 0.005 | -3 | 0.627 |
GCN2 |
0.756 | -0.112 | 2 | 0.738 |
MST4 |
0.756 | 0.017 | 2 | 0.797 |
CDK1 |
0.756 | 0.081 | 1 | 0.623 |
CK1E |
0.756 | 0.073 | -3 | 0.510 |
AMPKA1 |
0.755 | 0.010 | -3 | 0.688 |
PKN3 |
0.755 | -0.021 | -3 | 0.661 |
P38D |
0.755 | 0.127 | 1 | 0.566 |
CAMLCK |
0.755 | 0.002 | -2 | 0.730 |
DAPK2 |
0.755 | 0.009 | -3 | 0.700 |
ERK1 |
0.754 | 0.116 | 1 | 0.644 |
LATS2 |
0.754 | -0.017 | -5 | 0.607 |
MAK |
0.754 | 0.176 | -2 | 0.700 |
TBK1 |
0.754 | -0.101 | 1 | 0.545 |
PAK1 |
0.754 | 0.031 | -2 | 0.684 |
PRKX |
0.753 | 0.042 | -3 | 0.547 |
TSSK2 |
0.753 | 0.029 | -5 | 0.747 |
PKN2 |
0.753 | -0.012 | -3 | 0.681 |
IKKE |
0.753 | -0.089 | 1 | 0.531 |
ULK2 |
0.753 | -0.084 | 2 | 0.696 |
PKACG |
0.753 | -0.004 | -2 | 0.629 |
RSK4 |
0.753 | 0.025 | -3 | 0.596 |
NIK |
0.752 | -0.051 | -3 | 0.704 |
GSK3A |
0.752 | 0.132 | 4 | 0.537 |
CDK5 |
0.752 | 0.093 | 1 | 0.663 |
AMPKA2 |
0.752 | 0.009 | -3 | 0.657 |
TSSK1 |
0.752 | 0.029 | -3 | 0.706 |
CDK13 |
0.752 | 0.063 | 1 | 0.620 |
MLK2 |
0.751 | 0.040 | 2 | 0.739 |
TGFBR1 |
0.751 | 0.046 | -2 | 0.657 |
SRPK2 |
0.751 | 0.017 | -3 | 0.557 |
P70S6KB |
0.751 | -0.018 | -3 | 0.633 |
MSK1 |
0.751 | 0.021 | -3 | 0.614 |
ATM |
0.750 | -0.006 | 1 | 0.659 |
MASTL |
0.750 | -0.069 | -2 | 0.702 |
QSK |
0.750 | 0.035 | 4 | 0.718 |
RIPK3 |
0.750 | -0.062 | 3 | 0.608 |
GRK4 |
0.749 | -0.039 | -2 | 0.709 |
PDHK1 |
0.749 | -0.175 | 1 | 0.651 |
CLK4 |
0.749 | 0.038 | -3 | 0.624 |
DNAPK |
0.748 | 0.043 | 1 | 0.587 |
CDK12 |
0.748 | 0.071 | 1 | 0.596 |
BCKDK |
0.747 | -0.091 | -1 | 0.710 |
SRPK3 |
0.747 | 0.006 | -3 | 0.604 |
MSK2 |
0.747 | -0.016 | -3 | 0.617 |
MLK1 |
0.747 | -0.076 | 2 | 0.730 |
SMG1 |
0.747 | 0.016 | 1 | 0.671 |
MNK2 |
0.747 | 0.006 | -2 | 0.683 |
PAK3 |
0.746 | -0.001 | -2 | 0.679 |
NIM1 |
0.746 | 0.012 | 3 | 0.691 |
CDK3 |
0.746 | 0.086 | 1 | 0.573 |
AKT2 |
0.746 | 0.028 | -3 | 0.566 |
SGK3 |
0.746 | 0.041 | -3 | 0.627 |
PKCD |
0.746 | -0.022 | 2 | 0.702 |
NEK7 |
0.746 | -0.125 | -3 | 0.680 |
TTBK2 |
0.746 | -0.033 | 2 | 0.707 |
PRKD3 |
0.745 | 0.007 | -3 | 0.625 |
MPSK1 |
0.745 | 0.166 | 1 | 0.696 |
JNK1 |
0.745 | 0.105 | 1 | 0.588 |
PKCB |
0.745 | 0.018 | 2 | 0.654 |
DYRK1A |
0.745 | 0.067 | 1 | 0.676 |
CDK9 |
0.745 | 0.061 | 1 | 0.625 |
CLK1 |
0.745 | 0.040 | -3 | 0.608 |
HIPK3 |
0.744 | 0.099 | 1 | 0.666 |
CDK17 |
0.744 | 0.073 | 1 | 0.552 |
CK1D |
0.744 | 0.059 | -3 | 0.469 |
TLK2 |
0.744 | 0.017 | 1 | 0.650 |
PAK6 |
0.744 | 0.052 | -2 | 0.596 |
LATS1 |
0.744 | 0.003 | -3 | 0.673 |
TGFBR2 |
0.744 | -0.088 | -2 | 0.639 |
PRP4 |
0.744 | 0.082 | -3 | 0.700 |
GSK3B |
0.744 | 0.101 | 4 | 0.533 |
NEK9 |
0.744 | -0.071 | 2 | 0.759 |
ALK4 |
0.743 | -0.012 | -2 | 0.683 |
DCAMKL1 |
0.742 | 0.025 | -3 | 0.639 |
BRSK1 |
0.742 | -0.021 | -3 | 0.637 |
DYRK1B |
0.742 | 0.066 | 1 | 0.626 |
DLK |
0.742 | -0.145 | 1 | 0.668 |
MLK3 |
0.742 | -0.037 | 2 | 0.671 |
MARK3 |
0.742 | 0.012 | 4 | 0.668 |
PASK |
0.741 | 0.049 | -3 | 0.699 |
RIPK1 |
0.741 | -0.119 | 1 | 0.670 |
PKG2 |
0.740 | 0.006 | -2 | 0.570 |
MYLK4 |
0.740 | -0.022 | -2 | 0.661 |
CK2A2 |
0.740 | 0.090 | 1 | 0.616 |
CK1A2 |
0.740 | 0.044 | -3 | 0.470 |
PKCG |
0.739 | -0.023 | 2 | 0.670 |
CK1G1 |
0.739 | 0.030 | -3 | 0.497 |
DYRK3 |
0.739 | 0.052 | 1 | 0.680 |
ULK1 |
0.739 | -0.146 | -3 | 0.648 |
ALK2 |
0.739 | -0.002 | -2 | 0.665 |
ACVR2B |
0.739 | -0.005 | -2 | 0.644 |
PKCA |
0.739 | -0.013 | 2 | 0.639 |
VRK2 |
0.738 | -0.017 | 1 | 0.722 |
GRK2 |
0.738 | -0.012 | -2 | 0.598 |
PKR |
0.738 | -0.021 | 1 | 0.689 |
IRE1 |
0.738 | -0.075 | 1 | 0.669 |
MNK1 |
0.738 | -0.030 | -2 | 0.684 |
AURB |
0.738 | -0.009 | -2 | 0.549 |
PLK1 |
0.738 | -0.057 | -2 | 0.645 |
SIK |
0.738 | -0.021 | -3 | 0.602 |
PLK3 |
0.737 | -0.035 | 2 | 0.755 |
PIM2 |
0.737 | -0.003 | -3 | 0.601 |
PKCZ |
0.737 | -0.025 | 2 | 0.694 |
PKACA |
0.737 | 0.016 | -2 | 0.525 |
MELK |
0.737 | -0.054 | -3 | 0.642 |
QIK |
0.737 | -0.064 | -3 | 0.664 |
CDK16 |
0.736 | 0.074 | 1 | 0.565 |
CDK14 |
0.736 | 0.060 | 1 | 0.616 |
NUAK1 |
0.736 | -0.068 | -3 | 0.615 |
ACVR2A |
0.736 | -0.030 | -2 | 0.627 |
MEK1 |
0.736 | -0.089 | 2 | 0.783 |
MOK |
0.735 | 0.119 | 1 | 0.758 |
AURA |
0.735 | -0.017 | -2 | 0.520 |
GRK3 |
0.735 | 0.014 | -2 | 0.564 |
ANKRD3 |
0.735 | -0.151 | 1 | 0.697 |
CDK10 |
0.734 | 0.055 | 1 | 0.612 |
CHK1 |
0.734 | -0.058 | -3 | 0.629 |
YSK4 |
0.734 | -0.085 | 1 | 0.589 |
ERK2 |
0.734 | 0.039 | 1 | 0.660 |
MARK2 |
0.734 | -0.020 | 4 | 0.642 |
MST3 |
0.734 | 0.045 | 2 | 0.781 |
DRAK1 |
0.733 | -0.038 | 1 | 0.684 |
CAMK4 |
0.733 | -0.134 | -3 | 0.642 |
CK2A1 |
0.733 | 0.089 | 1 | 0.594 |
NEK2 |
0.733 | -0.056 | 2 | 0.731 |
BMPR1A |
0.733 | 0.011 | 1 | 0.661 |
BRSK2 |
0.732 | -0.068 | -3 | 0.647 |
WNK3 |
0.731 | -0.250 | 1 | 0.645 |
PAK2 |
0.731 | -0.068 | -2 | 0.661 |
ERK7 |
0.731 | 0.055 | 2 | 0.494 |
CDK2 |
0.730 | -0.007 | 1 | 0.669 |
SSTK |
0.729 | 0.014 | 4 | 0.701 |
MLK4 |
0.729 | -0.093 | 2 | 0.641 |
PHKG1 |
0.728 | -0.085 | -3 | 0.660 |
CAMK1G |
0.728 | -0.063 | -3 | 0.602 |
LKB1 |
0.728 | 0.055 | -3 | 0.676 |
PLK4 |
0.727 | -0.051 | 2 | 0.550 |
PKCH |
0.727 | -0.068 | 2 | 0.623 |
GAK |
0.727 | 0.050 | 1 | 0.726 |
MARK1 |
0.726 | -0.058 | 4 | 0.683 |
NEK5 |
0.726 | -0.027 | 1 | 0.692 |
MAPKAPK5 |
0.726 | -0.096 | -3 | 0.575 |
DCAMKL2 |
0.725 | -0.032 | -3 | 0.647 |
AKT1 |
0.725 | -0.012 | -3 | 0.577 |
CHAK1 |
0.725 | -0.136 | 2 | 0.704 |
SGK1 |
0.725 | 0.020 | -3 | 0.502 |
AKT3 |
0.725 | 0.022 | -3 | 0.527 |
TAO3 |
0.724 | -0.042 | 1 | 0.624 |
CK1A |
0.724 | 0.060 | -3 | 0.399 |
TLK1 |
0.724 | -0.078 | -2 | 0.696 |
MEKK3 |
0.723 | -0.110 | 1 | 0.637 |
WNK4 |
0.723 | -0.084 | -2 | 0.792 |
BRAF |
0.723 | -0.089 | -4 | 0.680 |
MEKK2 |
0.722 | -0.061 | 2 | 0.719 |
CAMK1D |
0.722 | -0.045 | -3 | 0.538 |
PINK1 |
0.722 | -0.137 | 1 | 0.732 |
PLK2 |
0.721 | -0.009 | -3 | 0.612 |
PDK1 |
0.721 | -0.002 | 1 | 0.664 |
MEK5 |
0.720 | -0.172 | 2 | 0.742 |
SBK |
0.720 | 0.013 | -3 | 0.464 |
DAPK3 |
0.719 | -0.022 | -3 | 0.644 |
PERK |
0.719 | -0.124 | -2 | 0.685 |
MEKK1 |
0.719 | -0.130 | 1 | 0.623 |
DAPK1 |
0.718 | -0.013 | -3 | 0.638 |
CAMKK1 |
0.718 | -0.062 | -2 | 0.630 |
PAK4 |
0.718 | 0.002 | -2 | 0.542 |
CAMKK2 |
0.718 | -0.038 | -2 | 0.629 |
ZAK |
0.718 | -0.137 | 1 | 0.595 |
PKCT |
0.717 | -0.053 | 2 | 0.629 |
SMMLCK |
0.717 | -0.083 | -3 | 0.659 |
P70S6K |
0.717 | -0.068 | -3 | 0.563 |
NEK11 |
0.717 | -0.087 | 1 | 0.630 |
PAK5 |
0.716 | -0.028 | -2 | 0.537 |
GCK |
0.716 | -0.039 | 1 | 0.636 |
TNIK |
0.716 | 0.018 | 3 | 0.744 |
SNRK |
0.715 | -0.173 | 2 | 0.561 |
PKCE |
0.715 | -0.033 | 2 | 0.647 |
IRE2 |
0.715 | -0.169 | 2 | 0.620 |
MEKK6 |
0.714 | 0.015 | 1 | 0.650 |
PBK |
0.714 | 0.048 | 1 | 0.670 |
BUB1 |
0.714 | 0.045 | -5 | 0.676 |
IRAK4 |
0.714 | -0.108 | 1 | 0.656 |
HPK1 |
0.714 | -0.020 | 1 | 0.613 |
CDK6 |
0.713 | 0.028 | 1 | 0.598 |
HRI |
0.713 | -0.200 | -2 | 0.702 |
PKCI |
0.713 | -0.064 | 2 | 0.661 |
ROCK2 |
0.713 | 0.001 | -3 | 0.634 |
CDK4 |
0.712 | 0.028 | 1 | 0.583 |
TAK1 |
0.711 | -0.046 | 1 | 0.672 |
MAP3K15 |
0.711 | -0.023 | 1 | 0.590 |
TTBK1 |
0.710 | -0.111 | 2 | 0.638 |
MRCKB |
0.710 | -0.021 | -3 | 0.590 |
CAMK1A |
0.709 | -0.045 | -3 | 0.538 |
HGK |
0.709 | -0.046 | 3 | 0.732 |
MINK |
0.709 | -0.044 | 1 | 0.614 |
KHS1 |
0.708 | -0.004 | 1 | 0.599 |
VRK1 |
0.708 | -0.051 | 2 | 0.750 |
EEF2K |
0.708 | -0.054 | 3 | 0.704 |
PDHK3_TYR |
0.708 | 0.210 | 4 | 0.830 |
LRRK2 |
0.708 | -0.097 | 2 | 0.765 |
PKN1 |
0.708 | -0.049 | -3 | 0.584 |
TAO2 |
0.706 | -0.133 | 2 | 0.761 |
NEK4 |
0.706 | -0.103 | 1 | 0.615 |
NEK1 |
0.706 | -0.057 | 1 | 0.641 |
MST2 |
0.705 | -0.108 | 1 | 0.629 |
KHS2 |
0.705 | -0.021 | 1 | 0.616 |
NEK8 |
0.705 | -0.190 | 2 | 0.721 |
YANK3 |
0.704 | 0.002 | 2 | 0.471 |
CHK2 |
0.704 | -0.056 | -3 | 0.523 |
DMPK1 |
0.704 | -0.008 | -3 | 0.612 |
PHKG2 |
0.703 | -0.147 | -3 | 0.638 |
STK33 |
0.701 | -0.095 | 2 | 0.618 |
MRCKA |
0.701 | -0.064 | -3 | 0.588 |
MAP2K4_TYR |
0.700 | 0.135 | -1 | 0.787 |
HASPIN |
0.699 | 0.006 | -1 | 0.677 |
LOK |
0.699 | -0.105 | -2 | 0.644 |
MAP2K6_TYR |
0.699 | 0.107 | -1 | 0.785 |
CRIK |
0.699 | -0.016 | -3 | 0.574 |
YSK1 |
0.699 | -0.060 | 2 | 0.729 |
IRAK1 |
0.698 | -0.237 | -1 | 0.641 |
PDHK4_TYR |
0.697 | 0.039 | 2 | 0.813 |
BMPR2_TYR |
0.695 | 0.064 | -1 | 0.790 |
PKMYT1_TYR |
0.695 | 0.098 | 3 | 0.753 |
SLK |
0.694 | -0.136 | -2 | 0.585 |
MEK2 |
0.694 | -0.163 | 2 | 0.730 |
OSR1 |
0.693 | -0.070 | 2 | 0.731 |
BIKE |
0.693 | 0.012 | 1 | 0.634 |
PKG1 |
0.693 | -0.054 | -2 | 0.500 |
MST1 |
0.693 | -0.168 | 1 | 0.605 |
LIMK2_TYR |
0.692 | 0.071 | -3 | 0.714 |
ROCK1 |
0.692 | -0.042 | -3 | 0.599 |
TESK1_TYR |
0.692 | -0.039 | 3 | 0.793 |
PDHK1_TYR |
0.690 | -0.005 | -1 | 0.775 |
MAP2K7_TYR |
0.690 | -0.076 | 2 | 0.784 |
EPHA6 |
0.689 | 0.102 | -1 | 0.739 |
MYO3B |
0.689 | -0.040 | 2 | 0.737 |
NEK3 |
0.689 | -0.096 | 1 | 0.593 |
AAK1 |
0.688 | 0.064 | 1 | 0.563 |
ASK1 |
0.688 | -0.061 | 1 | 0.573 |
EPHB4 |
0.687 | 0.069 | -1 | 0.710 |
ABL2 |
0.684 | 0.080 | -1 | 0.687 |
TXK |
0.682 | 0.070 | 1 | 0.713 |
ABL1 |
0.681 | 0.071 | -1 | 0.675 |
CK1G3 |
0.681 | -0.008 | -3 | 0.361 |
ALPHAK3 |
0.679 | -0.100 | -1 | 0.697 |
TTK |
0.679 | -0.133 | -2 | 0.670 |
RIPK2 |
0.679 | -0.285 | 1 | 0.555 |
PINK1_TYR |
0.679 | -0.190 | 1 | 0.704 |
TNK2 |
0.678 | 0.053 | 3 | 0.630 |
LIMK1_TYR |
0.677 | -0.123 | 2 | 0.761 |
FGR |
0.676 | -0.005 | 1 | 0.746 |
EPHA4 |
0.675 | -0.005 | 2 | 0.767 |
RET |
0.675 | -0.135 | 1 | 0.637 |
MYO3A |
0.675 | -0.122 | 1 | 0.594 |
DDR1 |
0.675 | -0.075 | 4 | 0.736 |
TAO1 |
0.673 | -0.149 | 1 | 0.539 |
SRMS |
0.672 | -0.023 | 1 | 0.710 |
FER |
0.671 | -0.083 | 1 | 0.739 |
EPHB3 |
0.671 | -0.013 | -1 | 0.687 |
MST1R |
0.670 | -0.150 | 3 | 0.684 |
JAK2 |
0.670 | -0.118 | 1 | 0.629 |
TYRO3 |
0.670 | -0.114 | 3 | 0.673 |
YANK2 |
0.670 | -0.023 | 2 | 0.483 |
ITK |
0.669 | -0.015 | -1 | 0.663 |
EPHB1 |
0.669 | -0.044 | 1 | 0.702 |
ROS1 |
0.669 | -0.105 | 3 | 0.647 |
CSF1R |
0.669 | -0.104 | 3 | 0.663 |
BLK |
0.669 | 0.033 | -1 | 0.687 |
YES1 |
0.669 | -0.076 | -1 | 0.696 |
EPHB2 |
0.669 | -0.023 | -1 | 0.680 |
CK1G2 |
0.669 | 0.000 | -3 | 0.432 |
TYK2 |
0.668 | -0.180 | 1 | 0.631 |
BMX |
0.668 | 0.010 | -1 | 0.632 |
LCK |
0.668 | -0.002 | -1 | 0.691 |
HCK |
0.667 | -0.042 | -1 | 0.684 |
MERTK |
0.667 | -0.028 | 3 | 0.665 |
STLK3 |
0.667 | -0.173 | 1 | 0.550 |
JAK3 |
0.666 | -0.107 | 1 | 0.636 |
FYN |
0.666 | 0.013 | -1 | 0.677 |
INSRR |
0.665 | -0.110 | 3 | 0.625 |
MET |
0.665 | -0.049 | 3 | 0.661 |
TNNI3K_TYR |
0.664 | -0.026 | 1 | 0.668 |
PTK2 |
0.663 | 0.054 | -1 | 0.686 |
TNK1 |
0.663 | -0.060 | 3 | 0.670 |
KIT |
0.662 | -0.115 | 3 | 0.664 |
NEK10_TYR |
0.662 | -0.107 | 1 | 0.526 |
EPHA7 |
0.661 | -0.036 | 2 | 0.750 |
FGFR2 |
0.660 | -0.156 | 3 | 0.678 |
EPHA3 |
0.660 | -0.065 | 2 | 0.726 |
KDR |
0.659 | -0.130 | 3 | 0.625 |
JAK1 |
0.659 | -0.078 | 1 | 0.566 |
SYK |
0.659 | 0.026 | -1 | 0.684 |
PTK2B |
0.658 | -0.016 | -1 | 0.630 |
AXL |
0.657 | -0.128 | 3 | 0.652 |
DDR2 |
0.657 | -0.036 | 3 | 0.603 |
FLT1 |
0.657 | -0.106 | -1 | 0.716 |
WEE1_TYR |
0.656 | -0.117 | -1 | 0.681 |
LTK |
0.654 | -0.091 | 3 | 0.627 |
NTRK3 |
0.653 | -0.077 | -1 | 0.682 |
TEC |
0.653 | -0.104 | -1 | 0.600 |
PTK6 |
0.653 | -0.164 | -1 | 0.622 |
SRC |
0.652 | -0.050 | -1 | 0.667 |
EPHA5 |
0.652 | -0.068 | 2 | 0.730 |
FGFR1 |
0.652 | -0.182 | 3 | 0.647 |
MATK |
0.652 | -0.077 | -1 | 0.645 |
CSK |
0.651 | -0.081 | 2 | 0.754 |
EPHA8 |
0.651 | -0.059 | -1 | 0.687 |
EGFR |
0.651 | -0.068 | 1 | 0.517 |
NTRK1 |
0.650 | -0.184 | -1 | 0.706 |
PDGFRB |
0.650 | -0.238 | 3 | 0.673 |
BTK |
0.650 | -0.185 | -1 | 0.631 |
FGFR3 |
0.650 | -0.150 | 3 | 0.645 |
LYN |
0.650 | -0.088 | 3 | 0.586 |
ERBB2 |
0.650 | -0.156 | 1 | 0.595 |
ZAP70 |
0.649 | 0.030 | -1 | 0.654 |
EPHA1 |
0.649 | -0.108 | 3 | 0.634 |
TEK |
0.649 | -0.216 | 3 | 0.608 |
INSR |
0.648 | -0.131 | 3 | 0.601 |
ALK |
0.648 | -0.158 | 3 | 0.594 |
FLT3 |
0.648 | -0.239 | 3 | 0.661 |
FGFR4 |
0.646 | -0.081 | -1 | 0.665 |
FRK |
0.646 | -0.122 | -1 | 0.687 |
EPHA2 |
0.643 | -0.058 | -1 | 0.669 |
PDGFRA |
0.642 | -0.288 | 3 | 0.665 |
ERBB4 |
0.641 | -0.046 | 1 | 0.551 |
FLT4 |
0.640 | -0.222 | 3 | 0.631 |
NTRK2 |
0.639 | -0.239 | 3 | 0.610 |
IGF1R |
0.634 | -0.130 | 3 | 0.546 |
MUSK |
0.628 | -0.151 | 1 | 0.522 |
FES |
0.624 | -0.116 | -1 | 0.609 |