Motif 310 (n=213)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | Y539 | ochoa | Golgin A8 family member Q | None |
| A2A288 | ZC3H12D | S329 | ochoa | Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) | May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}. |
| A6NMD2 | GOLGA8J | Y539 | ochoa | Golgin subfamily A member 8J | None |
| A8CG34 | POM121C | S970 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| C9JTQ0 | ANKRD63 | S193 | ochoa | Ankyrin repeat domain-containing protein 63 | None |
| H3BQL2 | GOLGA8T | Y538 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | Y539 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | Y538 | ochoa | Golgin subfamily A member 8R | None |
| O00178 | GTPBP1 | S44 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00478 | BTN3A3 | S214 | ochoa | Butyrophilin subfamily 3 member A3 | Plays a role in T-cell responses in the adaptive immune response. {ECO:0000269|PubMed:22767497}. |
| O00512 | BCL9 | S913 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14514 | ADGRB1 | S1278 | ochoa | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}. |
| O14519 | CDK2AP1 | S24 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O14654 | IRS4 | S1107 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S2719 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O60346 | PHLPP1 | S143 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S144 | ochoa | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60346 | PHLPP1 | S450 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60784 | TOM1 | S462 | ochoa | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) | Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582). {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:15657082, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31371777}. |
| O75179 | ANKRD17 | T227 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75376 | NCOR1 | S1592 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75385 | ULK1 | S716 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75970 | MPDZ | S1585 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O75970 | MPDZ | S1587 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O95071 | UBR5 | S1775 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95359 | TACC2 | S161 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95503 | CBX6 | S275 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95758 | PTBP3 | S161 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O96005 | CLPTM1 | S27 | ochoa | Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}. |
| P00519 | ABL1 | S855 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P05386 | RPLP1 | S83 | ochoa | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | Plays an important role in the elongation step of protein synthesis. |
| P08253 | MMP2 | S205 | ochoa | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
| P08833 | IGFBP1 | S126 | psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
| P09874 | PARP1 | S375 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0C7U0 | ELFN1 | S674 | ochoa | Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| P0CJ92 | GOLGA8H | Y539 | ochoa | Golgin subfamily A member 8H | None |
| P10412 | H1-4 | S58 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10588 | NR2F6 | S149 | ochoa | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}. |
| P10746 | UROS | S240 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P13804 | ETFA | S185 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P14859 | POU2F1 | S147 | psp | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P16401 | H1-5 | S61 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S59 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S36 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S58 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16989 | YBX3 | S34 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P18031 | PTPN1 | S393 | psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18887 | XRCC1 | S223 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19338 | NCL | S67 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P19419 | ELK1 | S200 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P19532 | TFE3 | S149 | ochoa | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
| P23025 | XPA | S23 | ochoa | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P23769 | GATA2 | S119 | psp | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P24394 | IL4R | Y575 | psp | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] | Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:17030238, ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}. |
| P25054 | APC | S2129 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S2130 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25100 | ADRA1D | S543 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P25440 | BRD2 | S37 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27816 | MAP4 | S825 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28290 | ITPRID2 | S593 | ochoa|psp | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29372 | MPG | S48 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P29372 | MPG | S49 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P29966 | MARCKS | S118 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P35221 | CTNNA1 | S117 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35568 | IRS1 | S1043 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S1133 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P40222 | TXLNA | S48 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P40227 | CCT6A | S428 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P40424 | PBX1 | S141 | ochoa | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) | Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786, PubMed:8327485). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}. |
| P40425 | PBX2 | S151 | ochoa | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. {ECO:0000269|PubMed:12609849}. |
| P41180 | CASR | S895 | psp | Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040, PubMed:34467854, PubMed:7759551, PubMed:8636323, PubMed:8702647, PubMed:8878438). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of downstream effectors (PubMed:38632411). CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G-proteins depending on the context (PubMed:38632411). In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G-proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity (PubMed:38632411, PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040). Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:32843625). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity). {ECO:0000250|UniProtKB:P48442, ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:32817431, ECO:0000269|PubMed:32843625, ECO:0000269|PubMed:33603117, ECO:0000269|PubMed:34194040, ECO:0000269|PubMed:34467854, ECO:0000269|PubMed:38632411, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}. |
| P42704 | LRPPRC | S54 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P43243 | MATR3 | S41 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46379 | BAG6 | S1084 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P48634 | PRRC2A | S1314 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P50454 | SERPINH1 | S37 | ochoa | Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47) | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| P50552 | VASP | S239 | ochoa|psp | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P54198 | HIRA | S538 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P55884 | EIF3B | S85 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P80723 | BASP1 | S164 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P85037 | FOXK1 | S295 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P85299 | PRR5 | S282 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
| Q00839 | HNRNPU | S192 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q02952 | AKAP12 | S887 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03252 | LMNB2 | S175 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q08379 | GOLGA2 | S792 | ochoa | Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) | Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. |
| Q12948 | FOXC1 | S262 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13459 | MYO9B | S1331 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13619 | CUL4A | S40 | ochoa | Cullin-4A (CUL-4A) | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620, PubMed:30166453, PubMed:33854232, PubMed:33854239). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DET1-COP1) directs ubiquitination of JUN (PubMed:14739464). DCX(DDB2) directs ubiquitination of XPC (PubMed:15811626). DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition (PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:14578910, PubMed:15448697, PubMed:15548678). DCX(DTL) directs autoubiquitination of DTL (PubMed:23478445). In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip (PubMed:16537899). Is involved in ubiquitination of HOXA9 (PubMed:14609952). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). The DCX(ERCC8) complex (also named CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:15811626, ECO:0000269|PubMed:16537899, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:24209620, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}. |
| Q13620 | CUL4B | T42 | ochoa | Cullin-4B (CUL-4B) | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}. |
| Q13685 | AAMP | S20 | ochoa | Angio-associated migratory cell protein | Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}. |
| Q14258 | TRIM25 | S433 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14258 | TRIM25 | S435 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14896 | MYBPC3 | S133 | psp | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q2M2I8 | AAK1 | S670 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q4V328 | GRIPAP1 | S318 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q5FWE3 | PRRT3 | S906 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5FWE3 | PRRT3 | S908 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JSZ5 | PRRC2B | S1507 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JSZ5 | PRRC2B | S1508 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTC6 | AMER1 | S45 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5SY16 | NOL9 | S84 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T4S7 | UBR4 | S3348 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5TGY3 | AHDC1 | S1544 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VZL5 | ZMYM4 | S882 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q63ZY3 | KANK2 | S151 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q69YQ0 | SPECC1L | S870 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q69YQ0 | SPECC1L | S889 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6DKI7 | PVRIG | S284 | ochoa | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}. |
| Q6P597 | KLC3 | S466 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q717R9 | CYS1 | S59 | ochoa | Cystin-1 (Cilia-associated protein) | None |
| Q7RTP6 | MICAL3 | S870 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Z1 | TICRR | T1265 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3C6 | ATG9A | S761 | ochoa|psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z434 | MAVS | S275 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5L9 | IRF2BP2 | S131 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86U86 | PBRM1 | S371 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86V48 | LUZP1 | S443 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86W50 | METTL16 | S453 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IV36 | HID1 | S616 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IWZ3 | ANKHD1 | S198 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IXS8 | HYCC2 | S491 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8IY63 | AMOTL1 | S809 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8N2M8 | CLASRP | T352 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N2M8 | CLASRP | T353 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N350 | CBARP | S282 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3K9 | CMYA5 | S1158 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3V7 | SYNPO | S698 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N5C8 | TAB3 | S672 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N5W9 | RFLNB | S74 | ochoa | Refilin-B (Regulator of filamin protein B) (RefilinB) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. {ECO:0000250|UniProtKB:Q5SVD0}. |
| Q8NBR6 | MINDY2 | S68 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8NC56 | LEMD2 | S175 | ochoa | LEM domain-containing protein 2 (hLEM2) | Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Q8ND56 | LSM14A | S219 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NE71 | ABCF1 | S287 | ochoa | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}. |
| Q8NEG4 | FAM83F | S104 | ochoa | Protein FAM83F | None |
| Q8NHG8 | ZNRF2 | S106 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8WWM7 | ATXN2L | T104 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WZ75 | ROBO4 | S896 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92539 | LPIN2 | S186 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92619 | ARHGAP45 | S880 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92766 | RREB1 | S848 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92793 | CREBBP | S976 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q96C57 | CUSTOS | S61 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96D71 | REPS1 | S740 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96G74 | OTUD5 | S450 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96HH4 | TMEM169 | S35 | ochoa | Transmembrane protein 169 | None |
| Q96JH8 | RADIL | S963 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96KQ7 | EHMT2 | S173 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96PK6 | RBM14 | S244 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S280 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PK6 | RBM14 | S523 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q99490 | AGAP2 | S638 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99700 | ATXN2 | S220 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQG0 | MYBBP1A | S1207 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BTC0 | DIDO1 | S1305 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTU6 | PI4K2A | S51 | ochoa|psp | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BXH1 | BBC3 | Y58 | psp | Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}. |
| Q9BYD3 | MRPL4 | S40 | ochoa | Large ribosomal subunit protein uL4m (39S ribosomal protein L4, mitochondrial) (L4mt) (MRP-L4) | None |
| Q9H0J9 | PARP12 | S70 | ochoa | Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}. |
| Q9H2P0 | ADNP | T440 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H2P0 | ADNP | S441 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H2P0 | ADNP | S442 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H3S7 | PTPN23 | S1126 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H6Z4 | RANBP3 | S359 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H7E9 | C8orf33 | S23 | ochoa | UPF0488 protein C8orf33 | None |
| Q9H7S9 | ZNF703 | S146 | ochoa | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. |
| Q9HCE7 | SMURF1 | S200 | ochoa | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}. |
| Q9NW82 | WDR70 | S621 | ochoa | WD repeat-containing protein 70 | None |
| Q9NWV8 | BABAM1 | S66 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NYV4 | CDK12 | S420 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZB2 | FAM120A | S925 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P244 | LRFN1 | S705 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P260 | RELCH | T88 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P2A4 | ABI3 | S216 | psp | ABI gene family member 3 (New molecule including SH3) (Nesh) | May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}. |
| Q9P2D3 | HEATR5B | S1564 | ochoa | HEAT repeat-containing protein 5B | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q9P2E9 | RRBP1 | S602 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2E9 | RRBP1 | S604 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UHD8 | SEPTIN9 | S111 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UJF2 | RASAL2 | S893 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKI8 | TLK1 | S41 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKX7 | NUP50 | S115 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULT8 | HECTD1 | S251 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9ULT8 | HECTD1 | S252 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UNF1 | MAGED2 | S247 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UPT6 | MAPK8IP3 | S273 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9UPU5 | USP24 | S1352 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQ35 | SRRM2 | T2275 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y210 | TRPC6 | Y31 | psp | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y2J4 | AMOTL2 | S727 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2U8 | LEMD3 | S95 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2W2 | WBP11 | S604 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y2X9 | ZNF281 | S117 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y490 | TLN1 | S1143 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B4 | RAD54L2 | S1197 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S1199 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F9 | RIPOR2 | S344 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y4H2 | IRS2 | S384 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S672 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5X4 | NR2E3 | S28 | ochoa | Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) | Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. {ECO:0000269|PubMed:15689355, ECO:0000269|PubMed:24069298}. |
| Q9Y5Y0 | FLVCR1 | Y22 | ochoa | Choline/ethanolamine transporter FLVCR1 (Feline leukemia virus subgroup C receptor-related protein 1) (Feline leukemia virus subgroup C receptor) (hFLVCR) (Heme transporter FLVCR1) | Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis (PubMed:37100056, PubMed:38693265, PubMed:38778100, PubMed:39306721). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265, PubMed:38778100). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265, PubMed:38778100). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265, ECO:0000269|PubMed:38778100, ECO:0000269|PubMed:39306721}.; FUNCTION: [Isoform 1]: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells (PubMed:37100056, PubMed:38693265). Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (PubMed:38693265). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (PubMed:38693265). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment (PubMed:15369674, PubMed:20610401, PubMed:22483575, PubMed:23187127, PubMed:27923065). Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity (PubMed:20610401). Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies (PubMed:20610401, PubMed:23187127). Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway (PubMed:20610401). Does not export bilirubin (PubMed:20610401). The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (PubMed:20610401, PubMed:23187127). {ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:22483575, ECO:0000269|PubMed:23187127, ECO:0000269|PubMed:27923065, ECO:0000269|PubMed:37100056, ECO:0000269|PubMed:38693265}.; FUNCTION: [Isoform 2]: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. {ECO:0000269|PubMed:23187127}.; FUNCTION: [Isoform 1]: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. {ECO:0000269|PubMed:10400745}. |
| Q9Y6I3 | EPN1 | S489 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| O43242 | PSMD3 | T69 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| P78316 | NOP14 | S29 | Sugiyama | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| O75676 | RPS6KA4 | S402 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| Q14257 | RCN2 | Y30 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| P07332 | FES | Y261 | Sugiyama | Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}. |
| P22102 | GART | S88 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| Q14957 | GRIN2C | S1081 | SIGNOR | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:36309015). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:36309015}. |
| O60563 | CCNT1 | S431 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| Q15751 | HERC1 | S3240 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| P58012 | FOXL2 | S263 | ELM|iPTMNet | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| Q9H4A3 | WNK1 | Y54 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9UM73 | ALK | S1449 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.000005 | 5.342 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.000036 | 4.447 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000312 | 3.506 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.000460 | 3.337 |
| R-HSA-68875 | Mitotic Prophase | 0.000597 | 3.224 |
| R-HSA-75153 | Apoptotic execution phase | 0.000978 | 3.010 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.001233 | 2.909 |
| R-HSA-74713 | IRS activation | 0.004312 | 2.365 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.002622 | 2.581 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.003185 | 2.497 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.004250 | 2.372 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.004101 | 2.387 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.002338 | 2.631 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.004101 | 2.387 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.003369 | 2.472 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.003369 | 2.472 |
| R-HSA-109581 | Apoptosis | 0.003724 | 2.429 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 0.013631 | 1.865 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.013631 | 1.865 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.013631 | 1.865 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 0.013631 | 1.865 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.008567 | 2.067 |
| R-HSA-112412 | SOS-mediated signalling | 0.008567 | 2.067 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.014094 | 1.851 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.016200 | 1.790 |
| R-HSA-4839744 | Signaling by APC mutants | 0.016200 | 1.790 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.016200 | 1.790 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.016200 | 1.790 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.016200 | 1.790 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.018432 | 1.734 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.020786 | 1.682 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.020786 | 1.682 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.020786 | 1.682 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.020786 | 1.682 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.020786 | 1.682 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.013817 | 1.860 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.014852 | 1.828 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.014852 | 1.828 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.017052 | 1.768 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.017052 | 1.768 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.018217 | 1.740 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.020676 | 1.685 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.023308 | 1.632 |
| R-HSA-198203 | PI3K/AKT activation | 0.014094 | 1.851 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.018217 | 1.740 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.009263 | 2.033 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.022771 | 1.643 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.022771 | 1.643 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.023290 | 1.633 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.023257 | 1.633 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.015931 | 1.798 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.014852 | 1.828 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.018432 | 1.734 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.023308 | 1.632 |
| R-HSA-74749 | Signal attenuation | 0.014094 | 1.851 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.014852 | 1.828 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.018217 | 1.740 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.019425 | 1.712 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.007064 | 2.151 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.021317 | 1.671 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.013817 | 1.860 |
| R-HSA-195721 | Signaling by WNT | 0.013241 | 1.878 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.007278 | 2.138 |
| R-HSA-5688426 | Deubiquitination | 0.014528 | 1.838 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.010964 | 1.960 |
| R-HSA-2559583 | Cellular Senescence | 0.006683 | 2.175 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.007743 | 2.111 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.018627 | 1.730 |
| R-HSA-2586552 | Signaling by Leptin | 0.014094 | 1.851 |
| R-HSA-5357801 | Programmed Cell Death | 0.013259 | 1.877 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.023515 | 1.629 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.026114 | 1.583 |
| R-HSA-201556 | Signaling by ALK | 0.026114 | 1.583 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.025241 | 1.598 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.024689 | 1.607 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.026114 | 1.583 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.028540 | 1.545 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.027581 | 1.559 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.028348 | 1.547 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.028348 | 1.547 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.029092 | 1.536 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.027581 | 1.559 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.027581 | 1.559 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.029092 | 1.536 |
| R-HSA-9609690 | HCMV Early Events | 0.030106 | 1.521 |
| R-HSA-189451 | Heme biosynthesis | 0.030646 | 1.514 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.031673 | 1.499 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.031343 | 1.504 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.034251 | 1.465 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.031257 | 1.505 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.035031 | 1.456 |
| R-HSA-162582 | Signal Transduction | 0.036496 | 1.438 |
| R-HSA-5693538 | Homology Directed Repair | 0.036591 | 1.437 |
| R-HSA-2028269 | Signaling by Hippo | 0.037260 | 1.429 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.037289 | 1.428 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.040340 | 1.394 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.040366 | 1.394 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.039055 | 1.408 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.038984 | 1.409 |
| R-HSA-73894 | DNA Repair | 0.038402 | 1.416 |
| R-HSA-3371556 | Cellular response to heat stress | 0.039650 | 1.402 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.039055 | 1.408 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.037594 | 1.425 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.042860 | 1.368 |
| R-HSA-73893 | DNA Damage Bypass | 0.044606 | 1.351 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.045084 | 1.346 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.045084 | 1.346 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.045084 | 1.346 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.046539 | 1.332 |
| R-HSA-73884 | Base Excision Repair | 0.048633 | 1.313 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.057246 | 1.242 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.057859 | 1.238 |
| R-HSA-2262752 | Cellular responses to stress | 0.049756 | 1.303 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.056665 | 1.247 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.053700 | 1.270 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.056808 | 1.246 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.056033 | 1.252 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.058980 | 1.229 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.058980 | 1.229 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.066329 | 1.178 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.066329 | 1.178 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.079060 | 1.102 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.091618 | 1.038 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.104005 | 0.983 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.104005 | 0.983 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.104005 | 0.983 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.116224 | 0.935 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.116224 | 0.935 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.128277 | 0.892 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.151895 | 0.818 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.151895 | 0.818 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.163464 | 0.787 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.064573 | 1.190 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.186133 | 0.730 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.197237 | 0.705 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.229652 | 0.639 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.105222 | 0.978 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.240165 | 0.619 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.063441 | 1.198 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.260764 | 0.584 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.319284 | 0.496 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.204515 | 0.689 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.335459 | 0.474 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.127752 | 0.894 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.208190 | 0.682 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.095975 | 1.018 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.262138 | 0.581 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.208190 | 0.682 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.092403 | 1.034 |
| R-HSA-354192 | Integrin signaling | 0.100896 | 0.996 |
| R-HSA-1221632 | Meiotic synapsis | 0.204515 | 0.689 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.309862 | 0.509 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.214504 | 0.669 |
| R-HSA-9843745 | Adipogenesis | 0.328067 | 0.484 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.355712 | 0.449 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.065729 | 1.182 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.197237 | 0.705 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.109596 | 0.960 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.250535 | 0.601 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.136766 | 0.864 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.101486 | 0.994 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.165218 | 0.782 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.109596 | 0.960 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.079060 | 1.102 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.197237 | 0.705 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.132138 | 0.879 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.119784 | 0.922 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.091618 | 1.038 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.091618 | 1.038 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.184713 | 0.734 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.194488 | 0.711 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.085341 | 1.069 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.280105 | 0.553 |
| R-HSA-3371568 | Attenuation phase | 0.136766 | 0.864 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.070416 | 1.152 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.186133 | 0.730 |
| R-HSA-525793 | Myogenesis | 0.072195 | 1.141 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.239649 | 0.620 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.239649 | 0.620 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.239649 | 0.620 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.239649 | 0.620 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.089910 | 1.046 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.151895 | 0.818 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.088240 | 1.054 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.122996 | 0.910 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.124321 | 0.905 |
| R-HSA-9609646 | HCMV Infection | 0.080580 | 1.094 |
| R-HSA-73927 | Depurination | 0.127547 | 0.894 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.091618 | 1.038 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.163464 | 0.787 |
| R-HSA-192814 | vRNA Synthesis | 0.174876 | 0.757 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.060871 | 1.216 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.064573 | 1.190 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.064573 | 1.190 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.186133 | 0.730 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.186133 | 0.730 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.096623 | 1.015 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.229652 | 0.639 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.229652 | 0.639 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.229652 | 0.639 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.309862 | 0.509 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.194581 | 0.711 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.224537 | 0.649 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.316941 | 0.499 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.121718 | 0.915 |
| R-HSA-9909396 | Circadian clock | 0.331798 | 0.479 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.197237 | 0.705 |
| R-HSA-112399 | IRS-mediated signalling | 0.224537 | 0.649 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.269988 | 0.569 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.140167 | 0.853 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.290625 | 0.537 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.165218 | 0.782 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.077720 | 1.109 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.072477 | 1.140 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.128277 | 0.892 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.140167 | 0.853 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.151895 | 0.818 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.163464 | 0.787 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.163464 | 0.787 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.218994 | 0.660 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.100896 | 0.996 |
| R-HSA-9707616 | Heme signaling | 0.249752 | 0.602 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.259867 | 0.585 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.080226 | 1.096 |
| R-HSA-5689603 | UCH proteinases | 0.320406 | 0.494 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.088250 | 1.054 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.091586 | 1.038 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.064573 | 1.190 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.186133 | 0.730 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.065729 | 1.182 |
| R-HSA-191859 | snRNP Assembly | 0.065729 | 1.182 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.070416 | 1.152 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.300309 | 0.522 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.355712 | 0.449 |
| R-HSA-68886 | M Phase | 0.105578 | 0.976 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.224893 | 0.648 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.166007 | 0.780 |
| R-HSA-9610379 | HCMV Late Events | 0.220950 | 0.656 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.179807 | 0.745 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.239649 | 0.620 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.320406 | 0.494 |
| R-HSA-9842663 | Signaling by LTK | 0.197237 | 0.705 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.355712 | 0.449 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.320406 | 0.494 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.116224 | 0.935 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.163464 | 0.787 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.076110 | 1.119 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.179043 | 0.747 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.109596 | 0.960 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.062799 | 1.202 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.160503 | 0.795 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.350283 | 0.456 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.088240 | 1.054 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.355712 | 0.449 |
| R-HSA-390696 | Adrenoceptors | 0.140167 | 0.853 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.151895 | 0.818 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.197237 | 0.705 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.197237 | 0.705 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.240165 | 0.619 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.309862 | 0.509 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.328579 | 0.483 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.264927 | 0.577 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.070416 | 1.152 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.290799 | 0.536 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.224893 | 0.648 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.330407 | 0.481 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.141430 | 0.849 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.136766 | 0.864 |
| R-HSA-9833110 | RSV-host interactions | 0.214194 | 0.669 |
| R-HSA-373755 | Semaphorin interactions | 0.254808 | 0.594 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.071510 | 1.146 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.330407 | 0.481 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.218935 | 0.660 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.091618 | 1.038 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.104005 | 0.983 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.174876 | 0.757 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.197237 | 0.705 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.197237 | 0.705 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.197237 | 0.705 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.218994 | 0.660 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.260764 | 0.584 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.309862 | 0.509 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.319284 | 0.496 |
| R-HSA-9766229 | Degradation of CDH1 | 0.184713 | 0.734 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.337748 | 0.471 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.210653 | 0.676 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.320603 | 0.494 |
| R-HSA-8939211 | ESR-mediated signaling | 0.144398 | 0.840 |
| R-HSA-162587 | HIV Life Cycle | 0.220950 | 0.656 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.209503 | 0.679 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.252318 | 0.598 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.096623 | 1.015 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.191519 | 0.718 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.089910 | 1.046 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.337748 | 0.471 |
| R-HSA-114608 | Platelet degranulation | 0.309413 | 0.509 |
| R-HSA-74160 | Gene expression (Transcription) | 0.144877 | 0.839 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.319284 | 0.496 |
| R-HSA-449836 | Other interleukin signaling | 0.280807 | 0.552 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.138945 | 0.857 |
| R-HSA-162906 | HIV Infection | 0.253054 | 0.597 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.268368 | 0.571 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.218994 | 0.660 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.260764 | 0.584 |
| R-HSA-109704 | PI3K Cascade | 0.189638 | 0.722 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.310369 | 0.508 |
| R-HSA-177929 | Signaling by EGFR | 0.219515 | 0.659 |
| R-HSA-157118 | Signaling by NOTCH | 0.149949 | 0.824 |
| R-HSA-4839726 | Chromatin organization | 0.167163 | 0.777 |
| R-HSA-913531 | Interferon Signaling | 0.320051 | 0.495 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.080091 | 1.096 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.250535 | 0.601 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.072814 | 1.138 |
| R-HSA-198753 | ERK/MAPK targets | 0.300309 | 0.522 |
| R-HSA-9620244 | Long-term potentiation | 0.346791 | 0.460 |
| R-HSA-3295583 | TRP channels | 0.355712 | 0.449 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.335529 | 0.474 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.062799 | 1.202 |
| R-HSA-1640170 | Cell Cycle | 0.204470 | 0.689 |
| R-HSA-168255 | Influenza Infection | 0.138494 | 0.859 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.295260 | 0.530 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.295260 | 0.530 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.320051 | 0.495 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.141430 | 0.849 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.199541 | 0.700 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.274795 | 0.561 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.241560 | 0.617 |
| R-HSA-5205647 | Mitophagy | 0.109596 | 0.960 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.114018 | 0.943 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.242944 | 0.614 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.140285 | 0.853 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.186052 | 0.730 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.128277 | 0.892 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.151895 | 0.818 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.328579 | 0.483 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.337748 | 0.471 |
| R-HSA-4086400 | PCP/CE pathway | 0.330407 | 0.481 |
| R-HSA-69481 | G2/M Checkpoints | 0.309413 | 0.509 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.300309 | 0.522 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.345332 | 0.462 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.300309 | 0.522 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.219515 | 0.659 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.249752 | 0.602 |
| R-HSA-212436 | Generic Transcription Pathway | 0.093494 | 1.029 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.259867 | 0.585 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.229632 | 0.639 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.309862 | 0.509 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.244698 | 0.611 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.229652 | 0.639 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.310369 | 0.508 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.163107 | 0.788 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.075158 | 1.124 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.272274 | 0.565 |
| R-HSA-450294 | MAP kinase activation | 0.244698 | 0.611 |
| R-HSA-381042 | PERK regulates gene expression | 0.114018 | 0.943 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.355712 | 0.449 |
| R-HSA-70171 | Glycolysis | 0.196626 | 0.706 |
| R-HSA-448424 | Interleukin-17 signaling | 0.290212 | 0.537 |
| R-HSA-422475 | Axon guidance | 0.092089 | 1.036 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.270854 | 0.567 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.290625 | 0.537 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.096847 | 1.014 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.266059 | 0.575 |
| R-HSA-9675108 | Nervous system development | 0.128687 | 0.890 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.072195 | 1.141 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.346791 | 0.460 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.206686 | 0.685 |
| R-HSA-9833482 | PKR-mediated signaling | 0.340368 | 0.468 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.076809 | 1.115 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.088240 | 1.054 |
| R-HSA-189445 | Metabolism of porphyrins | 0.095975 | 1.018 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.328579 | 0.483 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.313142 | 0.504 |
| R-HSA-449147 | Signaling by Interleukins | 0.063304 | 1.199 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.340368 | 0.468 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.250231 | 0.602 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.118485 | 0.926 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.345332 | 0.462 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.146127 | 0.835 |
| R-HSA-373752 | Netrin-1 signaling | 0.160403 | 0.795 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.107120 | 0.970 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.245643 | 0.610 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.250535 | 0.601 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.328579 | 0.483 |
| R-HSA-211000 | Gene Silencing by RNA | 0.082732 | 1.082 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.346791 | 0.460 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.346791 | 0.460 |
| R-HSA-70326 | Glucose metabolism | 0.268584 | 0.571 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.337748 | 0.471 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.337748 | 0.471 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.355222 | 0.450 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.159408 | 0.797 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.068349 | 1.165 |
| R-HSA-194138 | Signaling by VEGF | 0.128158 | 0.892 |
| R-HSA-75893 | TNF signaling | 0.219515 | 0.659 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.168360 | 0.774 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.364512 | 0.438 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.364512 | 0.438 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.364512 | 0.438 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.364512 | 0.438 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.364512 | 0.438 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.364512 | 0.438 |
| R-HSA-201451 | Signaling by BMP | 0.364512 | 0.438 |
| R-HSA-1483213 | Synthesis of PE | 0.364512 | 0.438 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.364512 | 0.438 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.364512 | 0.438 |
| R-HSA-1500620 | Meiosis | 0.365059 | 0.438 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.365059 | 0.438 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.365059 | 0.438 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.365059 | 0.438 |
| R-HSA-72172 | mRNA Splicing | 0.369502 | 0.432 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.373192 | 0.428 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.373192 | 0.428 |
| R-HSA-77387 | Insulin receptor recycling | 0.373192 | 0.428 |
| R-HSA-9638334 | Iron assimilation using enterobactin | 0.373192 | 0.428 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.373192 | 0.428 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.373192 | 0.428 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.374838 | 0.426 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.374838 | 0.426 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.378378 | 0.422 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.379705 | 0.421 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.380137 | 0.420 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.381754 | 0.418 |
| R-HSA-5334118 | DNA methylation | 0.381754 | 0.418 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 0.381754 | 0.418 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.381754 | 0.418 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.381754 | 0.418 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.381754 | 0.418 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.381754 | 0.418 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.384557 | 0.415 |
| R-HSA-9663891 | Selective autophagy | 0.384557 | 0.415 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.390199 | 0.409 |
| R-HSA-8953854 | Metabolism of RNA | 0.394400 | 0.404 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.398530 | 0.400 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.398530 | 0.400 |
| R-HSA-182971 | EGFR downregulation | 0.398530 | 0.400 |
| R-HSA-166520 | Signaling by NTRKs | 0.398557 | 0.400 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.399010 | 0.399 |
| R-HSA-9758941 | Gastrulation | 0.402224 | 0.396 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.403793 | 0.394 |
| R-HSA-68882 | Mitotic Anaphase | 0.406518 | 0.391 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.406747 | 0.391 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.406747 | 0.391 |
| R-HSA-391251 | Protein folding | 0.408558 | 0.389 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.409539 | 0.388 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.409587 | 0.388 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.413305 | 0.384 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.414852 | 0.382 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.414852 | 0.382 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.414852 | 0.382 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.414852 | 0.382 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.414852 | 0.382 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.414852 | 0.382 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.418033 | 0.379 |
| R-HSA-8951664 | Neddylation | 0.421832 | 0.375 |
| R-HSA-390522 | Striated Muscle Contraction | 0.422848 | 0.374 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.422848 | 0.374 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.422848 | 0.374 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.422848 | 0.374 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.427430 | 0.369 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.427430 | 0.369 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.430734 | 0.366 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.430734 | 0.366 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.430734 | 0.366 |
| R-HSA-392518 | Signal amplification | 0.430734 | 0.366 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.430734 | 0.366 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.430734 | 0.366 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.432099 | 0.364 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.432099 | 0.364 |
| R-HSA-877300 | Interferon gamma signaling | 0.438511 | 0.358 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.438513 | 0.358 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.438513 | 0.358 |
| R-HSA-169911 | Regulation of Apoptosis | 0.438513 | 0.358 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.438513 | 0.358 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.441377 | 0.355 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.441377 | 0.355 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.441377 | 0.355 |
| R-HSA-3214847 | HATs acetylate histones | 0.445984 | 0.351 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.446187 | 0.350 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.446187 | 0.350 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.446187 | 0.350 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.446187 | 0.350 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.446187 | 0.350 |
| R-HSA-3371511 | HSF1 activation | 0.446187 | 0.350 |
| R-HSA-8853659 | RET signaling | 0.446187 | 0.350 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.446187 | 0.350 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.450570 | 0.346 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.453756 | 0.343 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.453756 | 0.343 |
| R-HSA-4641258 | Degradation of DVL | 0.453756 | 0.343 |
| R-HSA-4641257 | Degradation of AXIN | 0.453756 | 0.343 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.453756 | 0.343 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.453756 | 0.343 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.455135 | 0.342 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.455135 | 0.342 |
| R-HSA-72312 | rRNA processing | 0.455167 | 0.342 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.459678 | 0.338 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.459678 | 0.338 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.461222 | 0.336 |
| R-HSA-5619102 | SLC transporter disorders | 0.466935 | 0.331 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.468586 | 0.329 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.468586 | 0.329 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.468586 | 0.329 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.468586 | 0.329 |
| R-HSA-69541 | Stabilization of p53 | 0.468586 | 0.329 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.468586 | 0.329 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.475850 | 0.323 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.475850 | 0.323 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.475850 | 0.323 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.475850 | 0.323 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.475850 | 0.323 |
| R-HSA-167169 | HIV Transcription Elongation | 0.475850 | 0.323 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.475850 | 0.323 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.475850 | 0.323 |
| R-HSA-202433 | Generation of second messenger molecules | 0.475850 | 0.323 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.477628 | 0.321 |
| R-HSA-168256 | Immune System | 0.480342 | 0.318 |
| R-HSA-72306 | tRNA processing | 0.480910 | 0.318 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.482059 | 0.317 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.483016 | 0.316 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.483016 | 0.316 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.483016 | 0.316 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.483016 | 0.316 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.483016 | 0.316 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.483016 | 0.316 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.483016 | 0.316 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.483016 | 0.316 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.484377 | 0.315 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.487833 | 0.312 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.490084 | 0.310 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.490084 | 0.310 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.490084 | 0.310 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.490084 | 0.310 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.490084 | 0.310 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.490084 | 0.310 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.490084 | 0.310 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.490852 | 0.309 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.490852 | 0.309 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.490852 | 0.309 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.490852 | 0.309 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.491278 | 0.309 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.491278 | 0.309 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.491278 | 0.309 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.495213 | 0.305 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.495213 | 0.305 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.497055 | 0.304 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.497055 | 0.304 |
| R-HSA-73928 | Depyrimidination | 0.497055 | 0.304 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.498134 | 0.303 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.499548 | 0.301 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.499550 | 0.301 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.499550 | 0.301 |
| R-HSA-202403 | TCR signaling | 0.499550 | 0.301 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.501639 | 0.300 |
| R-HSA-9710421 | Defective pyroptosis | 0.503932 | 0.298 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.503932 | 0.298 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.503932 | 0.298 |
| R-HSA-8854214 | TBC/RABGAPs | 0.503932 | 0.298 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.503932 | 0.298 |
| R-HSA-9907900 | Proteasome assembly | 0.510715 | 0.292 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.510715 | 0.292 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.510715 | 0.292 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.510715 | 0.292 |
| R-HSA-69236 | G1 Phase | 0.510715 | 0.292 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.510715 | 0.292 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.510715 | 0.292 |
| R-HSA-9824446 | Viral Infection Pathways | 0.511622 | 0.291 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.512419 | 0.290 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.512419 | 0.290 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.517406 | 0.286 |
| R-HSA-774815 | Nucleosome assembly | 0.517406 | 0.286 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.517406 | 0.286 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.517406 | 0.286 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.517406 | 0.286 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.517406 | 0.286 |
| R-HSA-9824272 | Somitogenesis | 0.517406 | 0.286 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.520877 | 0.283 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.524006 | 0.281 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.524006 | 0.281 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.524006 | 0.281 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.524006 | 0.281 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.524006 | 0.281 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.524006 | 0.281 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.524006 | 0.281 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.524006 | 0.281 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.525069 | 0.280 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.525427 | 0.279 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.529237 | 0.276 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.530516 | 0.275 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.530516 | 0.275 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.530516 | 0.275 |
| R-HSA-437239 | Recycling pathway of L1 | 0.530516 | 0.275 |
| R-HSA-1483191 | Synthesis of PC | 0.530516 | 0.275 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.533380 | 0.273 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.533380 | 0.273 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.536937 | 0.270 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.536937 | 0.270 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.537498 | 0.270 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.543271 | 0.265 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.543271 | 0.265 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.545659 | 0.263 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.545659 | 0.263 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.553719 | 0.257 |
| R-HSA-912446 | Meiotic recombination | 0.555681 | 0.255 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.555681 | 0.255 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.555681 | 0.255 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.555681 | 0.255 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.557712 | 0.254 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.557712 | 0.254 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.558906 | 0.253 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.561679 | 0.251 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.561759 | 0.250 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.561759 | 0.250 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.561759 | 0.250 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.561759 | 0.250 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.561759 | 0.250 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.561759 | 0.250 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.561759 | 0.250 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.561759 | 0.250 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.567128 | 0.246 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.567755 | 0.246 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.567755 | 0.246 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.567755 | 0.246 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.567755 | 0.246 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.567755 | 0.246 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.567755 | 0.246 |
| R-HSA-72649 | Translation initiation complex formation | 0.573669 | 0.241 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.573669 | 0.241 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.579503 | 0.237 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.579601 | 0.237 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.585257 | 0.233 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.585257 | 0.233 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.585257 | 0.233 |
| R-HSA-446728 | Cell junction organization | 0.585818 | 0.232 |
| R-HSA-1474165 | Reproduction | 0.596237 | 0.225 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.596531 | 0.224 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.596531 | 0.224 |
| R-HSA-8979227 | Triglyceride metabolism | 0.602053 | 0.220 |
| R-HSA-186712 | Regulation of beta-cell development | 0.602053 | 0.220 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.607500 | 0.216 |
| R-HSA-983189 | Kinesins | 0.607500 | 0.216 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.607500 | 0.216 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.607500 | 0.216 |
| R-HSA-351202 | Metabolism of polyamines | 0.607500 | 0.216 |
| R-HSA-1442490 | Collagen degradation | 0.612872 | 0.213 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.618172 | 0.209 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.618172 | 0.209 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.618172 | 0.209 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.621682 | 0.206 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.623399 | 0.205 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.623399 | 0.205 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.623399 | 0.205 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.623399 | 0.205 |
| R-HSA-8848021 | Signaling by PTK6 | 0.623399 | 0.205 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.628723 | 0.202 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.628723 | 0.202 |
| R-HSA-6807070 | PTEN Regulation | 0.632205 | 0.199 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.633641 | 0.198 |
| R-HSA-9664407 | Parasite infection | 0.635661 | 0.197 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.635661 | 0.197 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.635661 | 0.197 |
| R-HSA-418990 | Adherens junctions interactions | 0.635689 | 0.197 |
| R-HSA-1632852 | Macroautophagy | 0.639092 | 0.194 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.639092 | 0.194 |
| R-HSA-9830369 | Kidney development | 0.643605 | 0.191 |
| R-HSA-167172 | Transcription of the HIV genome | 0.648486 | 0.188 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.648486 | 0.188 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.648486 | 0.188 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.652565 | 0.185 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.658048 | 0.182 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.658048 | 0.182 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.658048 | 0.182 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.658048 | 0.182 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.658048 | 0.182 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.658048 | 0.182 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.659150 | 0.181 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.662732 | 0.179 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.662732 | 0.179 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.662732 | 0.179 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.662732 | 0.179 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.662732 | 0.179 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.665635 | 0.177 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.667351 | 0.176 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.667351 | 0.176 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.667351 | 0.176 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.671908 | 0.173 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.676403 | 0.170 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.676403 | 0.170 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.678309 | 0.169 |
| R-HSA-1500931 | Cell-Cell communication | 0.678895 | 0.168 |
| R-HSA-9679506 | SARS-CoV Infections | 0.679245 | 0.168 |
| R-HSA-8852135 | Protein ubiquitination | 0.680836 | 0.167 |
| R-HSA-917937 | Iron uptake and transport | 0.680836 | 0.167 |
| R-HSA-69306 | DNA Replication | 0.681416 | 0.167 |
| R-HSA-73887 | Death Receptor Signaling | 0.684498 | 0.165 |
| R-HSA-1989781 | PPARA activates gene expression | 0.687556 | 0.163 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.689522 | 0.161 |
| R-HSA-1266738 | Developmental Biology | 0.690022 | 0.161 |
| R-HSA-9612973 | Autophagy | 0.690590 | 0.161 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.693599 | 0.159 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.693776 | 0.159 |
| R-HSA-5619084 | ABC transporter disorders | 0.693776 | 0.159 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.697973 | 0.156 |
| R-HSA-9659379 | Sensory processing of sound | 0.697973 | 0.156 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.697973 | 0.156 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.702112 | 0.154 |
| R-HSA-6806834 | Signaling by MET | 0.702112 | 0.154 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.702484 | 0.153 |
| R-HSA-977225 | Amyloid fiber formation | 0.706195 | 0.151 |
| R-HSA-1280218 | Adaptive Immune System | 0.709892 | 0.149 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.714193 | 0.146 |
| R-HSA-421270 | Cell-cell junction organization | 0.720255 | 0.143 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.725787 | 0.139 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.725787 | 0.139 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.733255 | 0.135 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.736100 | 0.133 |
| R-HSA-156902 | Peptide chain elongation | 0.736912 | 0.133 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.736912 | 0.133 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.740520 | 0.130 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.743751 | 0.129 |
| R-HSA-202424 | Downstream TCR signaling | 0.744079 | 0.128 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.746321 | 0.127 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.747588 | 0.126 |
| R-HSA-416476 | G alpha (q) signalling events | 0.749113 | 0.125 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.751050 | 0.124 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.754465 | 0.122 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.754465 | 0.122 |
| R-HSA-1474290 | Collagen formation | 0.761155 | 0.119 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.764432 | 0.117 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.767664 | 0.115 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.770851 | 0.113 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.770851 | 0.113 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.770851 | 0.113 |
| R-HSA-69275 | G2/M Transition | 0.773160 | 0.112 |
| R-HSA-157579 | Telomere Maintenance | 0.773996 | 0.111 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.777097 | 0.110 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.777097 | 0.110 |
| R-HSA-422356 | Regulation of insulin secretion | 0.777097 | 0.110 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.777766 | 0.109 |
| R-HSA-109582 | Hemostasis | 0.779084 | 0.108 |
| R-HSA-597592 | Post-translational protein modification | 0.779786 | 0.108 |
| R-HSA-983712 | Ion channel transport | 0.780038 | 0.108 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.783173 | 0.106 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.784522 | 0.105 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.786149 | 0.104 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.789084 | 0.103 |
| R-HSA-1483255 | PI Metabolism | 0.789084 | 0.103 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.791979 | 0.101 |
| R-HSA-192823 | Viral mRNA Translation | 0.791979 | 0.101 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.794835 | 0.100 |
| R-HSA-418346 | Platelet homeostasis | 0.803170 | 0.095 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.805872 | 0.094 |
| R-HSA-69239 | Synthesis of DNA | 0.805872 | 0.094 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.808538 | 0.092 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.809780 | 0.092 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.811167 | 0.091 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.818841 | 0.087 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.818841 | 0.087 |
| R-HSA-397014 | Muscle contraction | 0.828784 | 0.082 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.830588 | 0.081 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.830947 | 0.080 |
| R-HSA-373760 | L1CAM interactions | 0.833270 | 0.079 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.835561 | 0.078 |
| R-HSA-73886 | Chromosome Maintenance | 0.844416 | 0.073 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.847173 | 0.072 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.848664 | 0.071 |
| R-HSA-69206 | G1/S Transition | 0.854820 | 0.068 |
| R-HSA-5663205 | Infectious disease | 0.863798 | 0.064 |
| R-HSA-72766 | Translation | 0.867463 | 0.062 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.870045 | 0.060 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.870045 | 0.060 |
| R-HSA-163685 | Integration of energy metabolism | 0.878742 | 0.056 |
| R-HSA-5368287 | Mitochondrial translation | 0.882056 | 0.055 |
| R-HSA-6798695 | Neutrophil degranulation | 0.895763 | 0.048 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.897323 | 0.047 |
| R-HSA-69242 | S Phase | 0.898737 | 0.046 |
| R-HSA-199991 | Membrane Trafficking | 0.899797 | 0.046 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.904202 | 0.044 |
| R-HSA-9609507 | Protein localization | 0.905521 | 0.043 |
| R-HSA-9711097 | Cellular response to starvation | 0.911853 | 0.040 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.911853 | 0.040 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.918896 | 0.037 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.918896 | 0.037 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.919504 | 0.036 |
| R-HSA-9658195 | Leishmania infection | 0.919504 | 0.036 |
| R-HSA-1483257 | Phospholipid metabolism | 0.931287 | 0.031 |
| R-HSA-392499 | Metabolism of proteins | 0.933855 | 0.030 |
| R-HSA-611105 | Respiratory electron transport | 0.934147 | 0.030 |
| R-HSA-168249 | Innate Immune System | 0.934581 | 0.029 |
| R-HSA-1643685 | Disease | 0.940160 | 0.027 |
| R-HSA-5617833 | Cilium Assembly | 0.944264 | 0.025 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.951501 | 0.022 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.952832 | 0.021 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.953484 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.953484 | 0.021 |
| R-HSA-1474244 | Extracellular matrix organization | 0.954560 | 0.020 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.959529 | 0.018 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.960064 | 0.018 |
| R-HSA-15869 | Metabolism of nucleotides | 0.971033 | 0.013 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.973071 | 0.012 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.980128 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 0.981732 | 0.008 |
| R-HSA-112316 | Neuronal System | 0.991310 | 0.004 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.991419 | 0.004 |
| R-HSA-8957322 | Metabolism of steroids | 0.991539 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.993334 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.995485 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.996700 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.996881 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.997898 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998093 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998192 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998284 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998683 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.859 | 0.237 | 2 | 0.846 |
CLK3 |
0.857 | 0.289 | 1 | 0.854 |
KIS |
0.852 | 0.311 | 1 | 0.789 |
HIPK4 |
0.851 | 0.316 | 1 | 0.838 |
MOS |
0.847 | 0.236 | 1 | 0.823 |
SRPK1 |
0.843 | 0.218 | -3 | 0.783 |
CDKL5 |
0.841 | 0.230 | -3 | 0.802 |
PIM3 |
0.841 | 0.129 | -3 | 0.852 |
NDR2 |
0.840 | 0.135 | -3 | 0.842 |
HIPK2 |
0.840 | 0.314 | 1 | 0.733 |
CDKL1 |
0.839 | 0.187 | -3 | 0.816 |
NLK |
0.839 | 0.203 | 1 | 0.873 |
GRK1 |
0.839 | 0.235 | -2 | 0.786 |
CDC7 |
0.838 | 0.079 | 1 | 0.787 |
MTOR |
0.838 | 0.103 | 1 | 0.795 |
ERK5 |
0.837 | 0.168 | 1 | 0.848 |
DYRK2 |
0.837 | 0.273 | 1 | 0.794 |
ICK |
0.836 | 0.246 | -3 | 0.836 |
PRKD1 |
0.836 | 0.167 | -3 | 0.807 |
CDK1 |
0.835 | 0.254 | 1 | 0.751 |
PRPK |
0.835 | 0.009 | -1 | 0.797 |
SKMLCK |
0.834 | 0.119 | -2 | 0.795 |
CDK18 |
0.833 | 0.265 | 1 | 0.729 |
CHAK2 |
0.832 | 0.128 | -1 | 0.757 |
JNK2 |
0.832 | 0.281 | 1 | 0.744 |
CDK5 |
0.832 | 0.254 | 1 | 0.795 |
HIPK1 |
0.832 | 0.278 | 1 | 0.805 |
IKKB |
0.831 | 0.015 | -2 | 0.667 |
CDK8 |
0.831 | 0.229 | 1 | 0.775 |
CDK19 |
0.831 | 0.245 | 1 | 0.747 |
MST4 |
0.830 | 0.097 | 2 | 0.857 |
PIM1 |
0.829 | 0.118 | -3 | 0.805 |
RAF1 |
0.829 | -0.005 | 1 | 0.804 |
P38A |
0.829 | 0.276 | 1 | 0.808 |
SRPK2 |
0.829 | 0.173 | -3 | 0.712 |
TBK1 |
0.829 | 0.031 | 1 | 0.719 |
P38B |
0.828 | 0.286 | 1 | 0.754 |
CLK2 |
0.828 | 0.223 | -3 | 0.774 |
ATR |
0.828 | 0.015 | 1 | 0.787 |
PRKD2 |
0.828 | 0.122 | -3 | 0.762 |
JNK3 |
0.828 | 0.253 | 1 | 0.765 |
ERK1 |
0.828 | 0.262 | 1 | 0.750 |
CAMK1B |
0.828 | 0.020 | -3 | 0.838 |
DSTYK |
0.828 | -0.003 | 2 | 0.865 |
NDR1 |
0.827 | 0.046 | -3 | 0.824 |
RSK2 |
0.827 | 0.103 | -3 | 0.771 |
P38G |
0.827 | 0.258 | 1 | 0.682 |
CDK7 |
0.827 | 0.219 | 1 | 0.786 |
BMPR2 |
0.826 | -0.076 | -2 | 0.803 |
SRPK3 |
0.826 | 0.151 | -3 | 0.769 |
IKKE |
0.826 | 0.018 | 1 | 0.721 |
BMPR1B |
0.826 | 0.140 | 1 | 0.741 |
GRK7 |
0.826 | 0.153 | 1 | 0.715 |
AURC |
0.825 | 0.080 | -2 | 0.569 |
PKN3 |
0.825 | 0.025 | -3 | 0.824 |
PDHK4 |
0.825 | -0.151 | 1 | 0.824 |
NEK6 |
0.825 | 0.005 | -2 | 0.771 |
GRK5 |
0.825 | -0.004 | -3 | 0.858 |
NUAK2 |
0.824 | 0.046 | -3 | 0.830 |
IKKA |
0.824 | 0.043 | -2 | 0.675 |
CDK3 |
0.824 | 0.228 | 1 | 0.701 |
MAK |
0.824 | 0.345 | -2 | 0.778 |
MLK1 |
0.823 | -0.005 | 2 | 0.792 |
P90RSK |
0.823 | 0.084 | -3 | 0.782 |
NIK |
0.823 | -0.008 | -3 | 0.850 |
PKN2 |
0.822 | 0.034 | -3 | 0.824 |
CAMLCK |
0.821 | 0.006 | -2 | 0.753 |
GCN2 |
0.821 | -0.135 | 2 | 0.769 |
CDK17 |
0.821 | 0.223 | 1 | 0.684 |
MLK2 |
0.821 | 0.047 | 2 | 0.811 |
WNK1 |
0.821 | -0.000 | -2 | 0.824 |
CK1E |
0.820 | 0.201 | -3 | 0.670 |
PKCD |
0.820 | 0.052 | 2 | 0.763 |
DAPK2 |
0.820 | 0.013 | -3 | 0.839 |
CDK13 |
0.820 | 0.187 | 1 | 0.763 |
DYRK1A |
0.820 | 0.234 | 1 | 0.818 |
TGFBR2 |
0.820 | -0.029 | -2 | 0.711 |
AMPKA1 |
0.820 | 0.034 | -3 | 0.833 |
ULK2 |
0.819 | -0.127 | 2 | 0.752 |
RIPK3 |
0.819 | -0.049 | 3 | 0.704 |
CAMK2G |
0.819 | -0.101 | 2 | 0.760 |
RSK3 |
0.819 | 0.064 | -3 | 0.774 |
MARK4 |
0.819 | 0.008 | 4 | 0.810 |
PKACG |
0.819 | 0.039 | -2 | 0.666 |
DYRK4 |
0.819 | 0.239 | 1 | 0.744 |
CLK4 |
0.818 | 0.135 | -3 | 0.773 |
NEK7 |
0.818 | -0.106 | -3 | 0.802 |
P70S6KB |
0.818 | 0.048 | -3 | 0.787 |
PKCB |
0.818 | 0.072 | 2 | 0.729 |
P38D |
0.818 | 0.258 | 1 | 0.699 |
CAMK2D |
0.817 | 0.015 | -3 | 0.806 |
PDHK1 |
0.817 | -0.154 | 1 | 0.810 |
MLK3 |
0.817 | 0.041 | 2 | 0.726 |
LATS2 |
0.817 | 0.015 | -5 | 0.709 |
HIPK3 |
0.817 | 0.227 | 1 | 0.799 |
MAPKAPK2 |
0.817 | 0.074 | -3 | 0.742 |
LATS1 |
0.817 | 0.075 | -3 | 0.833 |
MASTL |
0.816 | -0.121 | -2 | 0.757 |
GRK6 |
0.816 | -0.015 | 1 | 0.771 |
MAPKAPK3 |
0.816 | 0.033 | -3 | 0.765 |
CDK16 |
0.816 | 0.229 | 1 | 0.697 |
PKACB |
0.815 | 0.084 | -2 | 0.583 |
BCKDK |
0.815 | -0.056 | -1 | 0.763 |
GRK4 |
0.815 | 0.004 | -2 | 0.790 |
CLK1 |
0.815 | 0.144 | -3 | 0.738 |
RSK4 |
0.815 | 0.094 | -3 | 0.763 |
CDK12 |
0.814 | 0.191 | 1 | 0.742 |
AMPKA2 |
0.814 | 0.040 | -3 | 0.807 |
TGFBR1 |
0.814 | 0.041 | -2 | 0.741 |
PKCA |
0.814 | 0.061 | 2 | 0.716 |
PKR |
0.813 | 0.041 | 1 | 0.793 |
CDK14 |
0.813 | 0.209 | 1 | 0.763 |
MPSK1 |
0.813 | 0.224 | 1 | 0.771 |
DLK |
0.813 | -0.093 | 1 | 0.777 |
CAMK2B |
0.813 | 0.034 | 2 | 0.737 |
PRP4 |
0.813 | 0.172 | -3 | 0.787 |
CAMK2A |
0.812 | 0.046 | 2 | 0.753 |
NEK9 |
0.812 | -0.090 | 2 | 0.825 |
HUNK |
0.812 | -0.110 | 2 | 0.780 |
DYRK1B |
0.812 | 0.205 | 1 | 0.763 |
ALK4 |
0.812 | 0.004 | -2 | 0.760 |
PKCG |
0.812 | 0.036 | 2 | 0.717 |
ERK2 |
0.812 | 0.178 | 1 | 0.780 |
CK1D |
0.812 | 0.193 | -3 | 0.625 |
AKT2 |
0.811 | 0.102 | -3 | 0.707 |
CDK10 |
0.811 | 0.212 | 1 | 0.752 |
TSSK1 |
0.811 | 0.025 | -3 | 0.843 |
MST3 |
0.811 | 0.123 | 2 | 0.837 |
PAK1 |
0.811 | -0.003 | -2 | 0.694 |
TSSK2 |
0.810 | -0.021 | -5 | 0.832 |
IRE1 |
0.810 | -0.044 | 1 | 0.744 |
ANKRD3 |
0.810 | -0.123 | 1 | 0.800 |
PRKX |
0.810 | 0.095 | -3 | 0.704 |
YSK4 |
0.809 | -0.023 | 1 | 0.746 |
PRKD3 |
0.809 | 0.059 | -3 | 0.741 |
MNK2 |
0.809 | 0.008 | -2 | 0.696 |
PKCZ |
0.809 | 0.009 | 2 | 0.765 |
CDK9 |
0.809 | 0.154 | 1 | 0.767 |
QSK |
0.808 | 0.033 | 4 | 0.790 |
SGK3 |
0.808 | 0.075 | -3 | 0.767 |
VRK2 |
0.808 | -0.020 | 1 | 0.827 |
DYRK3 |
0.808 | 0.179 | 1 | 0.800 |
TTBK2 |
0.808 | -0.063 | 2 | 0.681 |
NIM1 |
0.808 | -0.039 | 3 | 0.709 |
TLK2 |
0.808 | 0.014 | 1 | 0.762 |
CDK2 |
0.808 | 0.104 | 1 | 0.798 |
FAM20C |
0.807 | 0.006 | 2 | 0.539 |
GSK3A |
0.807 | 0.126 | 4 | 0.494 |
PKG2 |
0.807 | 0.042 | -2 | 0.592 |
JNK1 |
0.807 | 0.208 | 1 | 0.729 |
ATM |
0.807 | -0.043 | 1 | 0.716 |
MSK2 |
0.806 | 0.007 | -3 | 0.770 |
MLK4 |
0.806 | -0.026 | 2 | 0.690 |
MSK1 |
0.806 | 0.038 | -3 | 0.769 |
AURB |
0.806 | 0.004 | -2 | 0.562 |
RIPK1 |
0.806 | -0.157 | 1 | 0.750 |
MOK |
0.806 | 0.273 | 1 | 0.805 |
ULK1 |
0.805 | -0.193 | -3 | 0.765 |
PASK |
0.805 | 0.082 | -3 | 0.867 |
ACVR2B |
0.805 | -0.001 | -2 | 0.713 |
PHKG1 |
0.805 | -0.016 | -3 | 0.811 |
DNAPK |
0.805 | 0.022 | 1 | 0.700 |
CK1A2 |
0.805 | 0.162 | -3 | 0.627 |
CK1G1 |
0.804 | 0.151 | -3 | 0.665 |
GRK2 |
0.804 | 0.006 | -2 | 0.677 |
PAK3 |
0.804 | -0.050 | -2 | 0.681 |
MEK1 |
0.804 | -0.119 | 2 | 0.807 |
ALK2 |
0.803 | -0.003 | -2 | 0.748 |
PKCH |
0.803 | -0.013 | 2 | 0.702 |
WNK3 |
0.803 | -0.231 | 1 | 0.773 |
ACVR2A |
0.803 | -0.019 | -2 | 0.696 |
TAO3 |
0.803 | 0.061 | 1 | 0.768 |
CHAK1 |
0.803 | -0.077 | 2 | 0.768 |
MNK1 |
0.803 | -0.015 | -2 | 0.707 |
PIM2 |
0.802 | 0.060 | -3 | 0.747 |
AURA |
0.802 | -0.003 | -2 | 0.533 |
PLK1 |
0.801 | -0.114 | -2 | 0.700 |
MEKK2 |
0.801 | 0.007 | 2 | 0.784 |
NUAK1 |
0.801 | -0.032 | -3 | 0.775 |
DCAMKL1 |
0.801 | 0.019 | -3 | 0.779 |
BMPR1A |
0.800 | 0.044 | 1 | 0.713 |
SIK |
0.800 | 0.008 | -3 | 0.755 |
IRE2 |
0.800 | -0.085 | 2 | 0.708 |
MELK |
0.800 | -0.042 | -3 | 0.778 |
NEK2 |
0.800 | -0.093 | 2 | 0.804 |
QIK |
0.800 | -0.084 | -3 | 0.798 |
NEK5 |
0.800 | -0.037 | 1 | 0.779 |
MEKK3 |
0.799 | -0.046 | 1 | 0.765 |
MEKK1 |
0.799 | -0.067 | 1 | 0.760 |
MYLK4 |
0.799 | -0.026 | -2 | 0.675 |
CAMK4 |
0.798 | -0.127 | -3 | 0.796 |
GCK |
0.798 | 0.112 | 1 | 0.798 |
PAK6 |
0.798 | 0.030 | -2 | 0.583 |
MARK3 |
0.798 | -0.012 | 4 | 0.743 |
ZAK |
0.797 | -0.074 | 1 | 0.725 |
GSK3B |
0.797 | 0.053 | 4 | 0.487 |
SMG1 |
0.797 | -0.083 | 1 | 0.744 |
BRSK1 |
0.797 | -0.031 | -3 | 0.787 |
GAK |
0.797 | 0.074 | 1 | 0.809 |
GRK3 |
0.797 | 0.040 | -2 | 0.648 |
MEK5 |
0.796 | -0.147 | 2 | 0.800 |
CHK1 |
0.796 | -0.053 | -3 | 0.790 |
PAK2 |
0.796 | -0.081 | -2 | 0.671 |
PKACA |
0.795 | 0.048 | -2 | 0.536 |
DRAK1 |
0.794 | -0.081 | 1 | 0.716 |
TNIK |
0.794 | 0.108 | 3 | 0.819 |
TLK1 |
0.794 | -0.059 | -2 | 0.762 |
AKT1 |
0.794 | 0.053 | -3 | 0.718 |
CDK6 |
0.794 | 0.168 | 1 | 0.745 |
PERK |
0.794 | -0.112 | -2 | 0.755 |
MARK2 |
0.793 | -0.044 | 4 | 0.707 |
NEK11 |
0.793 | -0.045 | 1 | 0.761 |
BRAF |
0.793 | -0.114 | -4 | 0.759 |
BRSK2 |
0.793 | -0.069 | -3 | 0.783 |
ERK7 |
0.792 | 0.058 | 2 | 0.516 |
LKB1 |
0.792 | 0.014 | -3 | 0.795 |
PKCT |
0.792 | -0.011 | 2 | 0.716 |
CDK4 |
0.791 | 0.175 | 1 | 0.733 |
WNK4 |
0.791 | -0.084 | -2 | 0.815 |
CAMK1G |
0.791 | -0.038 | -3 | 0.755 |
HPK1 |
0.791 | 0.083 | 1 | 0.787 |
MST2 |
0.790 | 0.002 | 1 | 0.781 |
AKT3 |
0.790 | 0.093 | -3 | 0.661 |
IRAK4 |
0.790 | -0.101 | 1 | 0.739 |
MINK |
0.790 | 0.061 | 1 | 0.778 |
PLK4 |
0.790 | -0.106 | 2 | 0.584 |
PKCE |
0.790 | 0.035 | 2 | 0.705 |
KHS1 |
0.790 | 0.122 | 1 | 0.778 |
KHS2 |
0.790 | 0.124 | 1 | 0.797 |
PLK3 |
0.789 | -0.147 | 2 | 0.716 |
PDK1 |
0.789 | -0.017 | 1 | 0.747 |
SGK1 |
0.789 | 0.092 | -3 | 0.646 |
SMMLCK |
0.789 | -0.054 | -3 | 0.803 |
PINK1 |
0.789 | -0.147 | 1 | 0.834 |
DAPK3 |
0.789 | 0.007 | -3 | 0.801 |
HGK |
0.788 | 0.030 | 3 | 0.810 |
MAP3K15 |
0.787 | 0.007 | 1 | 0.721 |
MEKK6 |
0.787 | -0.008 | 1 | 0.762 |
HRI |
0.787 | -0.208 | -2 | 0.751 |
CK2A2 |
0.787 | 0.036 | 1 | 0.687 |
TAO2 |
0.787 | -0.061 | 2 | 0.831 |
MAPKAPK5 |
0.787 | -0.069 | -3 | 0.724 |
ROCK2 |
0.786 | 0.075 | -3 | 0.785 |
EEF2K |
0.786 | -0.006 | 3 | 0.779 |
P70S6K |
0.785 | -0.003 | -3 | 0.708 |
SSTK |
0.785 | -0.044 | 4 | 0.768 |
MARK1 |
0.785 | -0.088 | 4 | 0.760 |
PKCI |
0.784 | -0.046 | 2 | 0.724 |
DCAMKL2 |
0.783 | -0.076 | -3 | 0.780 |
NEK8 |
0.783 | -0.157 | 2 | 0.793 |
DAPK1 |
0.782 | 0.002 | -3 | 0.795 |
CAMKK2 |
0.782 | -0.112 | -2 | 0.671 |
NEK4 |
0.782 | -0.084 | 1 | 0.762 |
CAMK1D |
0.782 | -0.005 | -3 | 0.690 |
MRCKB |
0.782 | 0.045 | -3 | 0.737 |
TAK1 |
0.782 | -0.025 | 1 | 0.791 |
SNRK |
0.782 | -0.206 | 2 | 0.639 |
CAMKK1 |
0.781 | -0.164 | -2 | 0.669 |
LRRK2 |
0.781 | -0.088 | 2 | 0.822 |
PDHK3_TYR |
0.780 | 0.235 | 4 | 0.885 |
PBK |
0.779 | 0.038 | 1 | 0.746 |
VRK1 |
0.779 | -0.045 | 2 | 0.810 |
LOK |
0.779 | -0.041 | -2 | 0.684 |
PAK5 |
0.779 | -0.030 | -2 | 0.532 |
PAK4 |
0.778 | -0.006 | -2 | 0.543 |
NEK1 |
0.778 | -0.073 | 1 | 0.749 |
PHKG2 |
0.778 | -0.081 | -3 | 0.764 |
CK2A1 |
0.778 | 0.031 | 1 | 0.670 |
BUB1 |
0.778 | 0.050 | -5 | 0.788 |
CK1A |
0.778 | 0.152 | -3 | 0.550 |
MST1 |
0.777 | -0.066 | 1 | 0.769 |
MRCKA |
0.776 | 0.009 | -3 | 0.745 |
OSR1 |
0.776 | 0.016 | 2 | 0.788 |
PKN1 |
0.776 | -0.008 | -3 | 0.712 |
SLK |
0.776 | -0.070 | -2 | 0.647 |
DMPK1 |
0.775 | 0.051 | -3 | 0.755 |
CHK2 |
0.775 | 0.022 | -3 | 0.647 |
YSK1 |
0.775 | -0.036 | 2 | 0.807 |
SBK |
0.775 | 0.077 | -3 | 0.593 |
MAP2K4_TYR |
0.772 | 0.110 | -1 | 0.819 |
PLK2 |
0.772 | -0.058 | -3 | 0.784 |
MAP2K6_TYR |
0.772 | 0.094 | -1 | 0.831 |
PDHK4_TYR |
0.771 | 0.080 | 2 | 0.844 |
TTBK1 |
0.771 | -0.174 | 2 | 0.589 |
HASPIN |
0.770 | 0.002 | -1 | 0.610 |
TESK1_TYR |
0.770 | 0.023 | 3 | 0.816 |
TTK |
0.770 | -0.038 | -2 | 0.738 |
CAMK1A |
0.769 | 0.001 | -3 | 0.672 |
ROCK1 |
0.769 | 0.030 | -3 | 0.749 |
BMPR2_TYR |
0.768 | 0.056 | -1 | 0.837 |
PDHK1_TYR |
0.768 | 0.055 | -1 | 0.845 |
PKMYT1_TYR |
0.768 | 0.044 | 3 | 0.797 |
IRAK1 |
0.767 | -0.309 | -1 | 0.658 |
CRIK |
0.767 | 0.049 | -3 | 0.718 |
LIMK2_TYR |
0.766 | 0.071 | -3 | 0.835 |
MYO3B |
0.766 | -0.012 | 2 | 0.815 |
MAP2K7_TYR |
0.764 | -0.102 | 2 | 0.826 |
STK33 |
0.764 | -0.175 | 2 | 0.575 |
MEK2 |
0.762 | -0.249 | 2 | 0.789 |
NEK3 |
0.760 | -0.137 | 1 | 0.719 |
MYO3A |
0.760 | -0.049 | 1 | 0.759 |
ABL2 |
0.759 | 0.051 | -1 | 0.732 |
ASK1 |
0.759 | -0.108 | 1 | 0.704 |
EPHA6 |
0.759 | 0.020 | -1 | 0.818 |
PKG1 |
0.758 | -0.023 | -2 | 0.504 |
YANK3 |
0.758 | -0.041 | 2 | 0.362 |
FGR |
0.758 | 0.025 | 1 | 0.796 |
TXK |
0.758 | 0.092 | 1 | 0.777 |
EPHB4 |
0.758 | 0.017 | -1 | 0.780 |
RET |
0.758 | -0.046 | 1 | 0.754 |
PINK1_TYR |
0.758 | -0.177 | 1 | 0.792 |
BIKE |
0.756 | -0.016 | 1 | 0.701 |
TAO1 |
0.756 | -0.077 | 1 | 0.699 |
ABL1 |
0.755 | 0.030 | -1 | 0.721 |
LCK |
0.755 | 0.069 | -1 | 0.783 |
ROS1 |
0.755 | -0.042 | 3 | 0.723 |
LIMK1_TYR |
0.754 | -0.127 | 2 | 0.824 |
BLK |
0.753 | 0.069 | -1 | 0.787 |
MST1R |
0.752 | -0.095 | 3 | 0.761 |
CSF1R |
0.752 | -0.045 | 3 | 0.735 |
JAK2 |
0.752 | -0.067 | 1 | 0.748 |
RIPK2 |
0.752 | -0.316 | 1 | 0.689 |
JAK3 |
0.752 | -0.056 | 1 | 0.728 |
TYK2 |
0.751 | -0.132 | 1 | 0.749 |
YES1 |
0.751 | -0.046 | -1 | 0.779 |
TYRO3 |
0.749 | -0.136 | 3 | 0.740 |
INSRR |
0.749 | -0.068 | 3 | 0.677 |
ALPHAK3 |
0.749 | -0.122 | -1 | 0.709 |
HCK |
0.749 | -0.035 | -1 | 0.768 |
TNNI3K_TYR |
0.748 | 0.007 | 1 | 0.761 |
CK1G3 |
0.747 | 0.097 | -3 | 0.514 |
KDR |
0.747 | -0.060 | 3 | 0.699 |
FYN |
0.746 | 0.050 | -1 | 0.771 |
FER |
0.746 | -0.124 | 1 | 0.795 |
JAK1 |
0.746 | -0.005 | 1 | 0.703 |
AAK1 |
0.746 | 0.034 | 1 | 0.616 |
TNK2 |
0.745 | -0.052 | 3 | 0.701 |
DDR1 |
0.745 | -0.181 | 4 | 0.783 |
ITK |
0.744 | -0.059 | -1 | 0.714 |
MET |
0.744 | -0.035 | 3 | 0.725 |
STLK3 |
0.744 | -0.176 | 1 | 0.703 |
SRMS |
0.743 | -0.085 | 1 | 0.772 |
EPHA4 |
0.743 | -0.080 | 2 | 0.718 |
KIT |
0.743 | -0.099 | 3 | 0.728 |
NEK10_TYR |
0.741 | -0.087 | 1 | 0.668 |
EPHB1 |
0.741 | -0.104 | 1 | 0.765 |
EPHB2 |
0.741 | -0.066 | -1 | 0.768 |
TNK1 |
0.740 | -0.088 | 3 | 0.731 |
EPHB3 |
0.740 | -0.089 | -1 | 0.765 |
BMX |
0.740 | -0.048 | -1 | 0.633 |
FLT1 |
0.739 | -0.062 | -1 | 0.798 |
FGFR2 |
0.739 | -0.156 | 3 | 0.718 |
CK1G2 |
0.738 | 0.096 | -3 | 0.596 |
MERTK |
0.737 | -0.108 | 3 | 0.710 |
PDGFRB |
0.737 | -0.200 | 3 | 0.742 |
SYK |
0.735 | 0.068 | -1 | 0.762 |
PTK2 |
0.735 | 0.043 | -1 | 0.780 |
FLT3 |
0.735 | -0.179 | 3 | 0.737 |
DDR2 |
0.735 | -0.037 | 3 | 0.664 |
WEE1_TYR |
0.733 | -0.119 | -1 | 0.655 |
FGFR1 |
0.733 | -0.180 | 3 | 0.696 |
LYN |
0.732 | -0.085 | 3 | 0.670 |
INSR |
0.732 | -0.134 | 3 | 0.674 |
ERBB2 |
0.732 | -0.138 | 1 | 0.703 |
FRK |
0.731 | -0.095 | -1 | 0.772 |
FGFR3 |
0.731 | -0.144 | 3 | 0.689 |
EPHA7 |
0.731 | -0.107 | 2 | 0.718 |
MATK |
0.731 | -0.094 | -1 | 0.668 |
TEK |
0.730 | -0.213 | 3 | 0.667 |
TEC |
0.730 | -0.141 | -1 | 0.627 |
ALK |
0.730 | -0.163 | 3 | 0.656 |
SRC |
0.730 | -0.051 | -1 | 0.756 |
AXL |
0.730 | -0.188 | 3 | 0.707 |
LTK |
0.728 | -0.166 | 3 | 0.687 |
EPHA3 |
0.728 | -0.155 | 2 | 0.691 |
BTK |
0.728 | -0.211 | -1 | 0.660 |
PDGFRA |
0.728 | -0.251 | 3 | 0.742 |
NTRK1 |
0.728 | -0.212 | -1 | 0.759 |
NTRK3 |
0.728 | -0.135 | -1 | 0.719 |
YANK2 |
0.726 | -0.064 | 2 | 0.371 |
PTK2B |
0.726 | -0.091 | -1 | 0.692 |
PTK6 |
0.726 | -0.226 | -1 | 0.632 |
EPHA1 |
0.726 | -0.156 | 3 | 0.711 |
EPHA8 |
0.725 | -0.100 | -1 | 0.757 |
EPHA5 |
0.724 | -0.118 | 2 | 0.698 |
ZAP70 |
0.724 | 0.042 | -1 | 0.674 |
FLT4 |
0.724 | -0.211 | 3 | 0.694 |
EGFR |
0.724 | -0.096 | 1 | 0.601 |
FGFR4 |
0.721 | -0.107 | -1 | 0.713 |
NTRK2 |
0.720 | -0.272 | 3 | 0.678 |
CSK |
0.720 | -0.143 | 2 | 0.722 |
ERBB4 |
0.718 | -0.047 | 1 | 0.622 |
IGF1R |
0.713 | -0.161 | 3 | 0.605 |
EPHA2 |
0.713 | -0.119 | -1 | 0.727 |
MUSK |
0.707 | -0.189 | 1 | 0.599 |
FES |
0.696 | -0.180 | -1 | 0.614 |