Motif 31 (n=155)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4FU49 | SH3D21 | S227 | ochoa | SH3 domain-containing protein 21 | None |
| A4UGR9 | XIRP2 | S2969 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| B2RTY4 | MYO9A | S1317 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S597 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| M0QZK8 | None | S51 | ochoa | gamma-glutamylcyclotransferase (EC 4.3.2.9) | None |
| O14686 | KMT2D | S1151 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14983 | ATP2A1 | S499 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15344 | MID1 | S524 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
| O15446 | POLR1G | S459 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O43166 | SIPA1L1 | S1528 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O60825 | PFKFB2 | S175 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O75152 | ZC3H11A | S295 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75223 | GGCT | S136 | ochoa | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
| O75417 | POLQ | S1414 | ochoa | DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] | Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}. |
| O95359 | TACC2 | S561 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95405 | ZFYVE9 | S306 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| O95425 | SVIL | S1120 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95613 | PCNT | S1632 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95810 | CAVIN2 | S169 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O96007 | MOCS2 | S20 | ochoa | Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit) | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}. |
| P04150 | NR3C1 | S211 | psp | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P06748 | NPM1 | S149 | ochoa | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P13639 | EEF2 | S595 | ochoa|psp | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P14923 | JUP | S671 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15260 | IFNGR1 | S327 | ochoa | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:28883123, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}. |
| P16949 | STMN1 | S38 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P17097 | ZNF7 | S397 | ochoa | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | May be involved in transcriptional regulation. |
| P22234 | PAICS | S107 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P24588 | AKAP5 | S92 | psp | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}. |
| P26640 | VARS1 | Y1227 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P29475 | NOS1 | S292 | ochoa | Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1) | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. {ECO:0000269|PubMed:35772285}. |
| P30622 | CLIP1 | S20 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P35251 | RFC1 | S1088 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35579 | MYH9 | S1243 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35611 | ADD1 | S366 | ochoa | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P40261 | NNMT | S108 | ochoa | Nicotinamide N-methyltransferase (EC 2.1.1.1) | Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23455543, PubMed:8182091). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (PubMed:23455543, PubMed:26571212, PubMed:31043742). In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (PubMed:26571212). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (PubMed:30044909). {ECO:0000250|UniProtKB:O55239, ECO:0000269|PubMed:21823666, ECO:0000269|PubMed:23455543, ECO:0000269|PubMed:26571212, ECO:0000269|PubMed:30044909, ECO:0000269|PubMed:31043742, ECO:0000269|PubMed:8182091}. |
| P46821 | MAP1B | S2098 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47736 | RAP1GAP | S74 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P47736 | RAP1GAP | S515 | ochoa | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P48634 | PRRC2A | S1306 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S1016 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49796 | RGS3 | S496 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P49796 | RGS3 | S674 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P51825 | AFF1 | S667 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P56524 | HDAC4 | S266 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P57679 | EVC | S81 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P82094 | TMF1 | S362 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q02880 | TOP2B | S1212 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02880 | TOP2B | S1424 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q05209 | PTPN12 | S332 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05682 | CALD1 | S628 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q06187 | BTK | S21 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q12888 | TP53BP1 | S727 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1678 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13002 | GRIK2 | S868 | psp | Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) | Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587, ECO:0000269|PubMed:7536611, ECO:0000269|PubMed:8730589}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}. |
| Q13009 | TIAM1 | S1466 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13330 | MTA1 | S522 | ochoa|psp | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13427 | PPIG | S690 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q14191 | WRN | S478 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14376 | GALE | S44 | ochoa | UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) | Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. {ECO:0000269|PubMed:22654673, ECO:0000303|PubMed:23732289}. |
| Q14596 | NBR1 | S590 | ochoa | Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) | Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352}. |
| Q14966 | ZNF638 | S1658 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14CW9 | ATXN7L3 | S180 | ochoa | Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) | Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). {ECO:0000255|HAMAP-Rule:MF_03047, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879, ECO:0000269|PubMed:27601583}. |
| Q15052 | ARHGEF6 | S622 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q16877 | PFKFB4 | S176 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. |
| Q1KMD3 | HNRNPUL2 | S597 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q1MSJ5 | CSPP1 | S401 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
| Q2TAZ0 | ATG2A | S775 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q3T8J9 | GON4L | S346 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q49A26 | GLYR1 | S223 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q58WW2 | DCAF6 | S478 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5BKX6 | SLC45A4 | S389 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5PSV4 | BRMS1L | S197 | ochoa | Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) | Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. {ECO:0000269|PubMed:15451426}. |
| Q5T5P2 | KIAA1217 | S1650 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5THK1 | PRR14L | S582 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5VUA4 | ZNF318 | S2101 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VYS8 | TUT7 | S939 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q5VYS8 | TUT7 | S960 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q5W0B1 | OBI1 | S210 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q5W0Z9 | ZDHHC20 | S328 | ochoa | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245). May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. {ECO:0000250|UniProtKB:Q5Y5T1, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245, ECO:0000269|PubMed:33219126}.; FUNCTION: (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q63HK5 | TSHZ3 | S463 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q6DT37 | CDC42BPG | S480 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IN85 | PPP4R3A | S698 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6P4F7 | ARHGAP11A | S484 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PJW8 | CNST | S348 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6R327 | RICTOR | S1353 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZV73 | FGD6 | S70 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z5J4 | RAI1 | S776 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5L2 | R3HCC1L | S338 | ochoa | Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) | None |
| Q8IVF2 | AHNAK2 | S593 | ochoa | Protein AHNAK2 | None |
| Q8IYI6 | EXOC8 | S372 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8IZT6 | ASPM | S253 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8IZT6 | ASPM | S612 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8NAP3 | ZBTB38 | S130 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NEM0 | MCPH1 | S102 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NEY1 | NAV1 | S362 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHV4 | NEDD1 | S516 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TEQ6 | GEMIN5 | S1267 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WW12 | PCNP | S77 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q92523 | CPT1B | S330 | ochoa | Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. {ECO:0000250|UniProtKB:Q63704}. |
| Q92817 | EVPL | S1698 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q93045 | STMN2 | S73 | psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q969H0 | FBXW7 | S349 | psp | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17434132, PubMed:22748924, PubMed:26976582, PubMed:28727686, PubMed:34741373, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:17434132, PubMed:22748924, PubMed:26774286, PubMed:26976582, PubMed:28727686, PubMed:34741373). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 (PubMed:11565034, PubMed:11585921, PubMed:12354302, PubMed:14739463, PubMed:15103331, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:25775507, PubMed:25897075, PubMed:26976582, PubMed:28007894, PubMed:28727686, PubMed:29149593, PubMed:34102342). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (PubMed:26774286). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (PubMed:26774286). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:35395208, ECO:0000305|PubMed:12354302}. |
| Q96D09 | GPRASP2 | S512 | ochoa | G-protein coupled receptor-associated sorting protein 2 (GASP-2) | May play a role in regulation of a variety of G-protein coupled receptors. {ECO:0000269|PubMed:15086532}. |
| Q96G28 | CFAP36 | S85 | ochoa | Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) | May act as an effector for ARL3. |
| Q96JM3 | CHAMP1 | S615 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KR7 | PHACTR3 | S318 | psp | Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin) | None |
| Q96MY1 | NOL4L | S130 | ochoa | Nucleolar protein 4-like | None |
| Q96RT1 | ERBIN | S857 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RU2 | USP28 | S279 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96ST8 | CEP89 | S221 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q96T23 | RSF1 | S700 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T58 | SPEN | S1222 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T88 | UHRF1 | S709 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q9BRK3 | MXRA8 | S423 | ochoa | Matrix remodeling-associated protein 8 (Limitrin) | Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q9DBV4, ECO:0000269|PubMed:22492581, ECO:0000269|PubMed:23386276}.; FUNCTION: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. {ECO:0000269|PubMed:29769725, ECO:0000269|PubMed:31080063}. |
| Q9BS16 | CENPK | S194 | ochoa | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}. |
| Q9BTC8 | MTA3 | S519 | ochoa | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9BW91 | NUDT9 | S121 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q9BX63 | BRIP1 | S956 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BYW2 | SETD2 | S614 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C005 | DPY30 | S19 | ochoa | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:19651892, ECO:0000269|PubMed:21335234}. |
| Q9C0B0 | UNK | S85 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9H2Y7 | ZNF106 | S1249 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H792 | PEAK1 | S730 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9HB58 | SP110 | S244 | ochoa | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). |
| Q9HCK8 | CHD8 | S2046 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQW6 | ANLN | S295 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR45 | NANS | S275 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
| Q9NR48 | ASH1L | S2825 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRS6 | SNX15 | S201 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NS87 | KIF15 | S568 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NX40 | OCIAD1 | S191 | ochoa | OCIA domain-containing protein 1 (Ovarian cancer immunoreactive antigen domain containing 1) (Ovarian carcinoma immunoreactive antigen) | Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). {ECO:0000250|UniProtKB:Q9CRD0, ECO:0000269|PubMed:20515946}. |
| Q9NXG2 | THUMPD1 | S270 | ochoa | THUMP domain-containing protein 1 | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}. |
| Q9NZ72 | STMN3 | S73 | ochoa|psp | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9P0N8 | MARCHF2 | S223 | ochoa | E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) | E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329, ECO:0000269|PubMed:17980554, ECO:0000269|PubMed:23818989, ECO:0000269|PubMed:31142615, ECO:0000269|PubMed:32935379}.; FUNCTION: (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway (PubMed:29573664). Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission (PubMed:29573664). {ECO:0000269|PubMed:29573664}. |
| Q9UGU5 | HMGXB4 | S166 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UHF7 | TRPS1 | S69 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UK61 | TASOR | S1219 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKK3 | PARP4 | S1236 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKV0 | HDAC9 | S240 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9UKV3 | ACIN1 | S525 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UL54 | TAOK2 | S827 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9UL63 | MKLN1 | S195 | ochoa | Muskelin | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924). {ECO:0000250|UniProtKB:O89050, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972}. |
| Q9ULD4 | BRPF3 | S400 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UM11 | FZR1 | S163 | psp | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. |
| Q9UPN3 | MACF1 | S6032 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPQ0 | LIMCH1 | S681 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQL6 | HDAC5 | S279 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y3L3 | SH3BP1 | S175 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y4D8 | HECTD4 | S595 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| O14893 | GEMIN2 | S131 | Sugiyama | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
| P07858 | CTSB | S216 | Sugiyama | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}. |
| Q06323 | PSME1 | S31 | Sugiyama | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| O14929 | HAT1 | S361 | Sugiyama | Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) | Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}. |
| Q13873 | BMPR2 | S233 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.517996e-07 | 6.345 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.922671e-04 | 3.406 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 8.634686e-04 | 3.064 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 8.634686e-04 | 3.064 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 8.634686e-04 | 3.064 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 8.634686e-04 | 3.064 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 8.634686e-04 | 3.064 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 1.353256e-03 | 2.869 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 1.353256e-03 | 2.869 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 1.935164e-03 | 2.713 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 1.935164e-03 | 2.713 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.828450e-03 | 2.738 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.709924e-03 | 2.767 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.169526e-03 | 2.664 |
| R-HSA-4839726 | Chromatin organization | 2.506950e-03 | 2.601 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.462792e-03 | 2.461 |
| R-HSA-73886 | Chromosome Maintenance | 3.410432e-03 | 2.467 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 8.653675e-03 | 2.063 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 9.967028e-03 | 2.001 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.283952e-02 | 1.891 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.250006e-02 | 1.903 |
| R-HSA-5693538 | Homology Directed Repair | 1.390028e-02 | 1.857 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.101563e-02 | 1.677 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.101563e-02 | 1.677 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.101563e-02 | 1.677 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.101563e-02 | 1.677 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.101563e-02 | 1.677 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.938758e-02 | 1.712 |
| R-HSA-774815 | Nucleosome assembly | 1.938758e-02 | 1.712 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.665477e-02 | 1.778 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.951634e-02 | 1.710 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.136933e-02 | 1.670 |
| R-HSA-1640170 | Cell Cycle | 2.415202e-02 | 1.617 |
| R-HSA-5609977 | Defective GALE causes EDG | 3.135819e-02 | 1.504 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.159212e-02 | 1.381 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.159212e-02 | 1.381 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.159212e-02 | 1.381 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.159212e-02 | 1.381 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.159212e-02 | 1.381 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.159212e-02 | 1.381 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.159212e-02 | 1.381 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.159212e-02 | 1.381 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.159212e-02 | 1.381 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.159212e-02 | 1.381 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.159212e-02 | 1.381 |
| R-HSA-451307 | Activation of Na-permeable kainate receptors | 5.171856e-02 | 1.286 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 6.173862e-02 | 1.209 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 7.165341e-02 | 1.145 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.146404e-02 | 1.089 |
| R-HSA-176417 | Phosphorylation of Emi1 | 8.146404e-02 | 1.089 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 9.117159e-02 | 1.040 |
| R-HSA-9842640 | Signaling by LTK in cancer | 9.117159e-02 | 1.040 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.007771e-01 | 0.997 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.102818e-01 | 0.957 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.734211e-02 | 1.563 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.196865e-01 | 0.922 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.946550e-02 | 1.531 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.946550e-02 | 1.531 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.946550e-02 | 1.531 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.946550e-02 | 1.531 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.473118e-01 | 0.832 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.348688e-02 | 1.362 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 5.394583e-02 | 1.268 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.828093e-01 | 0.738 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.914516e-01 | 0.718 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.914516e-01 | 0.718 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.000031e-01 | 0.699 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.000031e-01 | 0.699 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 2.000031e-01 | 0.699 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.168373e-01 | 0.664 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.414304e-01 | 0.617 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.494563e-01 | 0.603 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.494563e-01 | 0.603 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.633157e-01 | 0.787 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.106970e-01 | 0.508 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.745682e-01 | 0.758 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.745682e-01 | 0.758 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.859410e-01 | 0.731 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.128438e-01 | 0.672 |
| R-HSA-380287 | Centrosome maturation | 2.206021e-01 | 0.656 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.635756e-01 | 0.579 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.635756e-01 | 0.579 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.753290e-01 | 0.560 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.940784e-02 | 1.049 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.106970e-01 | 0.508 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.533434e-01 | 0.452 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.730309e-01 | 0.564 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.595950e-01 | 0.797 |
| R-HSA-191859 | snRNP Assembly | 1.595950e-01 | 0.797 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.828093e-01 | 0.738 |
| R-HSA-69091 | Polymerase switching | 1.563273e-01 | 0.806 |
| R-HSA-69109 | Leading Strand Synthesis | 1.563273e-01 | 0.806 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.251218e-01 | 0.648 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.958692e-01 | 0.529 |
| R-HSA-877300 | Interferon gamma signaling | 2.905892e-01 | 0.537 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.274473e-02 | 1.278 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.533434e-01 | 0.452 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.408835e-02 | 1.130 |
| R-HSA-8849473 | PTK6 Expression | 1.007771e-01 | 0.997 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 5.125413e-02 | 1.290 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 6.518991e-02 | 1.186 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.084647e-01 | 0.681 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.533434e-01 | 0.452 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.456784e-02 | 1.190 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.811382e-02 | 1.167 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 6.230990e-02 | 1.205 |
| R-HSA-397795 | G-protein beta:gamma signalling | 6.518991e-02 | 1.186 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.107408e-02 | 1.214 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.997743e-02 | 1.155 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.198917e-01 | 0.921 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 6.518991e-02 | 1.186 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.491422e-01 | 0.457 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.491422e-01 | 0.457 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.629882e-02 | 1.334 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.466505e-02 | 1.127 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.298931e-01 | 0.482 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.522032e-01 | 0.818 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 7.108037e-02 | 1.148 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.650915e-02 | 1.332 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 7.165341e-02 | 1.145 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 8.146404e-02 | 1.089 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.007771e-01 | 0.997 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.289924e-01 | 0.889 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.563273e-01 | 0.806 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 7.108037e-02 | 1.148 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 8.970868e-02 | 1.047 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.807243e-01 | 0.552 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.464224e-01 | 0.460 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.168373e-01 | 0.664 |
| R-HSA-201451 | Signaling by BMP | 2.958692e-01 | 0.529 |
| R-HSA-5334118 | DNA methylation | 3.106970e-01 | 0.508 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.464224e-01 | 0.460 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 5.668656e-02 | 1.247 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 8.334906e-02 | 1.079 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.448827e-01 | 0.839 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.652481e-01 | 0.782 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.670741e-02 | 1.435 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.935806e-01 | 0.713 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 8.970868e-02 | 1.047 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 8.970868e-02 | 1.047 |
| R-HSA-2424491 | DAP12 signaling | 3.179941e-01 | 0.498 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 3.390142e-02 | 1.470 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.473118e-01 | 0.832 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.168373e-01 | 0.664 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.179941e-01 | 0.498 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.179941e-01 | 0.498 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.557409e-01 | 0.592 |
| R-HSA-68877 | Mitotic Prometaphase | 1.898187e-01 | 0.722 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.883368e-01 | 0.540 |
| R-HSA-9664873 | Pexophagy | 1.289924e-01 | 0.889 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.730309e-01 | 0.564 |
| R-HSA-9663891 | Selective autophagy | 2.753290e-01 | 0.560 |
| R-HSA-9766229 | Degradation of CDH1 | 1.234147e-01 | 0.909 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.323587e-01 | 0.478 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 9.117159e-02 | 1.040 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 7.408835e-02 | 1.130 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.958692e-01 | 0.529 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.394277e-01 | 0.469 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 9.620659e-02 | 1.017 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.414304e-01 | 0.617 |
| R-HSA-73894 | DNA Repair | 2.185721e-01 | 0.660 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.168373e-01 | 0.664 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.456784e-02 | 1.190 |
| R-HSA-157579 | Telomere Maintenance | 1.085981e-01 | 0.964 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 7.165341e-02 | 1.145 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.563273e-01 | 0.806 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.563273e-01 | 0.806 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.084647e-01 | 0.681 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.767219e-02 | 1.239 |
| R-HSA-429947 | Deadenylation of mRNA | 2.730309e-01 | 0.564 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.807243e-01 | 0.552 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.958692e-01 | 0.529 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.252144e-01 | 0.488 |
| R-HSA-5578775 | Ion homeostasis | 1.485336e-01 | 0.828 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.106970e-01 | 0.508 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.196865e-01 | 0.922 |
| R-HSA-5635838 | Activation of SMO | 1.914516e-01 | 0.718 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.464224e-01 | 0.460 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.633157e-01 | 0.787 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.668656e-02 | 1.247 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.146404e-02 | 1.089 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.146404e-02 | 1.089 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.007771e-01 | 0.997 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.654287e-02 | 1.437 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.333192e-01 | 0.632 |
| R-HSA-3214847 | HATs acetylate histones | 1.130639e-01 | 0.947 |
| R-HSA-69190 | DNA strand elongation | 3.323587e-01 | 0.478 |
| R-HSA-5617833 | Cilium Assembly | 1.834595e-01 | 0.736 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.084647e-01 | 0.681 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.394277e-01 | 0.469 |
| R-HSA-9843745 | Adipogenesis | 2.060990e-01 | 0.686 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.792454e-01 | 0.554 |
| R-HSA-180786 | Extension of Telomeres | 1.595950e-01 | 0.797 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.106970e-01 | 0.508 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.601826e-01 | 0.585 |
| R-HSA-70370 | Galactose catabolism | 2.000031e-01 | 0.699 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 8.970868e-02 | 1.047 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.412512e-01 | 0.850 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 9.294089e-02 | 1.032 |
| R-HSA-69275 | G2/M Transition | 1.750947e-01 | 0.757 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.792605e-01 | 0.747 |
| R-HSA-9659379 | Sensory processing of sound | 2.361841e-01 | 0.627 |
| R-HSA-9675135 | Diseases of DNA repair | 1.130010e-01 | 0.947 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.563273e-01 | 0.806 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 8.022386e-02 | 1.096 |
| R-HSA-392517 | Rap1 signalling | 2.251218e-01 | 0.648 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.333192e-01 | 0.632 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.485336e-01 | 0.828 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.106970e-01 | 0.508 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.935806e-01 | 0.713 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.012602e-01 | 0.696 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.866719e-01 | 0.543 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 9.294089e-02 | 1.032 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.007771e-01 | 0.997 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.251218e-01 | 0.648 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.485336e-01 | 0.828 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.106970e-01 | 0.508 |
| R-HSA-69481 | G2/M Checkpoints | 1.925915e-01 | 0.715 |
| R-HSA-73884 | Base Excision Repair | 2.831604e-01 | 0.548 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.382005e-01 | 0.859 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.652481e-01 | 0.782 |
| R-HSA-8876725 | Protein methylation | 1.828093e-01 | 0.738 |
| R-HSA-174403 | Glutathione synthesis and recycling | 2.494563e-01 | 0.603 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.958692e-01 | 0.529 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.443991e-02 | 1.463 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.394277e-01 | 0.469 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.464224e-01 | 0.460 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.752381e-01 | 0.756 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.948932e-01 | 0.530 |
| R-HSA-74160 | Gene expression (Transcription) | 1.085667e-01 | 0.964 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.196865e-01 | 0.922 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.828093e-01 | 0.738 |
| R-HSA-200425 | Carnitine shuttle | 2.652557e-01 | 0.576 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.793224e-01 | 0.746 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.958692e-01 | 0.529 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.807243e-01 | 0.552 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.668656e-02 | 1.247 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.251218e-01 | 0.648 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.573977e-01 | 0.589 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.573977e-01 | 0.589 |
| R-HSA-196807 | Nicotinate metabolism | 1.897554e-01 | 0.722 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.128438e-01 | 0.672 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 3.394277e-01 | 0.469 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.225751e-01 | 0.912 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.165246e-02 | 1.500 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 8.970868e-02 | 1.047 |
| R-HSA-264876 | Insulin processing | 2.958692e-01 | 0.529 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.128438e-01 | 0.672 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 3.533434e-01 | 0.452 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.518991e-02 | 1.186 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.652557e-01 | 0.576 |
| R-HSA-6807070 | PTEN Regulation | 2.309215e-01 | 0.637 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.230990e-02 | 1.205 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.167197e-01 | 0.664 |
| R-HSA-182971 | EGFR downregulation | 3.252144e-01 | 0.488 |
| R-HSA-212436 | Generic Transcription Pathway | 1.633222e-01 | 0.787 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.283836e-01 | 0.641 |
| R-HSA-70171 | Glycolysis | 3.298931e-01 | 0.482 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.042311e-01 | 0.690 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.167197e-01 | 0.664 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.674937e-01 | 0.573 |
| R-HSA-75153 | Apoptotic execution phase | 1.130010e-01 | 0.947 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 1.288984e-01 | 0.890 |
| R-HSA-157118 | Signaling by NOTCH | 6.021866e-02 | 1.220 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.948932e-01 | 0.530 |
| R-HSA-9679506 | SARS-CoV Infections | 4.450431e-02 | 1.352 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.674937e-01 | 0.573 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.260240e-01 | 0.487 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.909847e-01 | 0.536 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.396852e-01 | 0.469 |
| R-HSA-418346 | Platelet homeostasis | 3.567915e-01 | 0.448 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.567915e-01 | 0.448 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.601916e-01 | 0.443 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.601916e-01 | 0.443 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.601916e-01 | 0.443 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.606043e-01 | 0.443 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.606043e-01 | 0.443 |
| R-HSA-69239 | Synthesis of DNA | 3.606043e-01 | 0.443 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.644088e-01 | 0.438 |
| R-HSA-8853659 | RET signaling | 3.669676e-01 | 0.435 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.669676e-01 | 0.435 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.669676e-01 | 0.435 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.682048e-01 | 0.434 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.736724e-01 | 0.428 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.736724e-01 | 0.428 |
| R-HSA-73927 | Depurination | 3.803065e-01 | 0.420 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 3.865239e-01 | 0.413 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.868707e-01 | 0.412 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.868707e-01 | 0.412 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.868707e-01 | 0.412 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.933658e-01 | 0.405 |
| R-HSA-9646399 | Aggrephagy | 3.933658e-01 | 0.405 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.933658e-01 | 0.405 |
| R-HSA-5260271 | Diseases of Immune System | 3.933658e-01 | 0.405 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.933658e-01 | 0.405 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.982382e-01 | 0.400 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.994656e-01 | 0.399 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.997925e-01 | 0.398 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.997925e-01 | 0.398 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.997925e-01 | 0.398 |
| R-HSA-9694548 | Maturation of spike protein | 3.997925e-01 | 0.398 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.997925e-01 | 0.398 |
| R-HSA-70326 | Glucose metabolism | 4.056457e-01 | 0.392 |
| R-HSA-162582 | Signal Transduction | 4.058633e-01 | 0.392 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.061515e-01 | 0.391 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.061515e-01 | 0.391 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.124436e-01 | 0.385 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.124436e-01 | 0.385 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.130096e-01 | 0.384 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.186693e-01 | 0.378 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.203286e-01 | 0.376 |
| R-HSA-2172127 | DAP12 interactions | 4.248295e-01 | 0.372 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.248295e-01 | 0.372 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.248295e-01 | 0.372 |
| R-HSA-156581 | Methylation | 4.248295e-01 | 0.372 |
| R-HSA-9907900 | Proteasome assembly | 4.248295e-01 | 0.372 |
| R-HSA-68886 | M Phase | 4.262794e-01 | 0.370 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.276012e-01 | 0.369 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.303346e-01 | 0.366 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.312197e-01 | 0.365 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.369558e-01 | 0.360 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.369558e-01 | 0.360 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.369558e-01 | 0.360 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.384205e-01 | 0.358 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.384205e-01 | 0.358 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.384205e-01 | 0.358 |
| R-HSA-194138 | Signaling by VEGF | 4.384205e-01 | 0.358 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.429233e-01 | 0.354 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.429233e-01 | 0.354 |
| R-HSA-397014 | Muscle contraction | 4.476948e-01 | 0.349 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.476948e-01 | 0.349 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.488279e-01 | 0.348 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.488279e-01 | 0.348 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.488279e-01 | 0.348 |
| R-HSA-73893 | DNA Damage Bypass | 4.546703e-01 | 0.342 |
| R-HSA-5576891 | Cardiac conduction | 4.632266e-01 | 0.334 |
| R-HSA-72187 | mRNA 3'-end processing | 4.718307e-01 | 0.326 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.718307e-01 | 0.326 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.718307e-01 | 0.326 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.718307e-01 | 0.326 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.718307e-01 | 0.326 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.718307e-01 | 0.326 |
| R-HSA-1643685 | Disease | 4.759903e-01 | 0.322 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.774306e-01 | 0.321 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.774306e-01 | 0.321 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.774306e-01 | 0.321 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.774306e-01 | 0.321 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.829715e-01 | 0.316 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.829715e-01 | 0.316 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.883956e-01 | 0.311 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.938788e-01 | 0.306 |
| R-HSA-177929 | Signaling by EGFR | 4.938788e-01 | 0.306 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.941620e-01 | 0.306 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.975298e-01 | 0.303 |
| R-HSA-9664407 | Parasite infection | 4.975298e-01 | 0.303 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.975298e-01 | 0.303 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.992463e-01 | 0.302 |
| R-HSA-1632852 | Macroautophagy | 5.008834e-01 | 0.300 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.008834e-01 | 0.300 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.045572e-01 | 0.297 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.045572e-01 | 0.297 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.098121e-01 | 0.293 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.098121e-01 | 0.293 |
| R-HSA-4085001 | Sialic acid metabolism | 5.098121e-01 | 0.293 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.098121e-01 | 0.293 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.119947e-01 | 0.291 |
| R-HSA-983189 | Kinesins | 5.150117e-01 | 0.288 |
| R-HSA-156590 | Glutathione conjugation | 5.150117e-01 | 0.288 |
| R-HSA-379724 | tRNA Aminoacylation | 5.150117e-01 | 0.288 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.201563e-01 | 0.284 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.201563e-01 | 0.284 |
| R-HSA-1442490 | Collagen degradation | 5.201563e-01 | 0.284 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.252468e-01 | 0.280 |
| R-HSA-9707616 | Heme signaling | 5.252468e-01 | 0.280 |
| R-HSA-186797 | Signaling by PDGF | 5.252468e-01 | 0.280 |
| R-HSA-69242 | S Phase | 5.271919e-01 | 0.278 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.302835e-01 | 0.275 |
| R-HSA-8848021 | Signaling by PTK6 | 5.302835e-01 | 0.275 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.302835e-01 | 0.275 |
| R-HSA-373755 | Semaphorin interactions | 5.302835e-01 | 0.275 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.352671e-01 | 0.271 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.374471e-01 | 0.270 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.399930e-01 | 0.268 |
| R-HSA-69306 | DNA Replication | 5.431560e-01 | 0.265 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.450772e-01 | 0.264 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.463039e-01 | 0.263 |
| R-HSA-73887 | Death Receptor Signaling | 5.463039e-01 | 0.263 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.499047e-01 | 0.260 |
| R-HSA-9612973 | Autophagy | 5.525545e-01 | 0.258 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.525633e-01 | 0.258 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.546813e-01 | 0.256 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.648741e-01 | 0.248 |
| R-HSA-9824446 | Viral Infection Pathways | 5.650208e-01 | 0.248 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.687109e-01 | 0.245 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.687109e-01 | 0.245 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.687109e-01 | 0.245 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.687109e-01 | 0.245 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.687109e-01 | 0.245 |
| R-HSA-109581 | Apoptosis | 5.709426e-01 | 0.243 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.732890e-01 | 0.242 |
| R-HSA-74259 | Purine catabolism | 5.732890e-01 | 0.242 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.769501e-01 | 0.239 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.778189e-01 | 0.238 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.778189e-01 | 0.238 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.823009e-01 | 0.235 |
| R-HSA-1280218 | Adaptive Immune System | 5.842297e-01 | 0.233 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.867357e-01 | 0.232 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.902929e-01 | 0.229 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.060677e-01 | 0.217 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.060677e-01 | 0.217 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.082169e-01 | 0.216 |
| R-HSA-9833482 | PKR-mediated signaling | 6.082169e-01 | 0.216 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.082169e-01 | 0.216 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.088951e-01 | 0.215 |
| R-HSA-446728 | Cell junction organization | 6.149398e-01 | 0.211 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.164953e-01 | 0.210 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.164953e-01 | 0.210 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.172007e-01 | 0.210 |
| R-HSA-913531 | Interferon Signaling | 6.240278e-01 | 0.205 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.245997e-01 | 0.204 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.285878e-01 | 0.202 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.336521e-01 | 0.198 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.364381e-01 | 0.196 |
| R-HSA-70268 | Pyruvate metabolism | 6.403012e-01 | 0.194 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.403012e-01 | 0.194 |
| R-HSA-156902 | Peptide chain elongation | 6.441235e-01 | 0.191 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.546229e-01 | 0.184 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.622382e-01 | 0.179 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.626375e-01 | 0.179 |
| R-HSA-391251 | Protein folding | 6.626375e-01 | 0.179 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.662237e-01 | 0.176 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.662237e-01 | 0.176 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.672402e-01 | 0.176 |
| R-HSA-1474290 | Collagen formation | 6.697721e-01 | 0.174 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.770660e-01 | 0.169 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.801937e-01 | 0.167 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.801937e-01 | 0.167 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.801937e-01 | 0.167 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.835944e-01 | 0.165 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.835944e-01 | 0.165 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.869591e-01 | 0.163 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.869591e-01 | 0.163 |
| R-HSA-422356 | Regulation of insulin secretion | 6.869591e-01 | 0.163 |
| R-HSA-72172 | mRNA Splicing | 6.890169e-01 | 0.162 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.902883e-01 | 0.161 |
| R-HSA-5357801 | Programmed Cell Death | 6.913633e-01 | 0.160 |
| R-HSA-6805567 | Keratinization | 6.936952e-01 | 0.159 |
| R-HSA-1500931 | Cell-Cell communication | 6.945201e-01 | 0.158 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.032566e-01 | 0.153 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.064134e-01 | 0.151 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.077534e-01 | 0.150 |
| R-HSA-9833110 | RSV-host interactions | 7.095368e-01 | 0.149 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.126272e-01 | 0.147 |
| R-HSA-68882 | Mitotic Anaphase | 7.162263e-01 | 0.145 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.184017e-01 | 0.144 |
| R-HSA-418990 | Adherens junctions interactions | 7.205630e-01 | 0.142 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.246653e-01 | 0.140 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.246653e-01 | 0.140 |
| R-HSA-8951664 | Neddylation | 7.269640e-01 | 0.138 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.362019e-01 | 0.133 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.373582e-01 | 0.132 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.390101e-01 | 0.131 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.414211e-01 | 0.130 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.417887e-01 | 0.130 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.472578e-01 | 0.127 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.526118e-01 | 0.123 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.552464e-01 | 0.122 |
| R-HSA-15869 | Metabolism of nucleotides | 7.571422e-01 | 0.121 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.578530e-01 | 0.120 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.578530e-01 | 0.120 |
| R-HSA-68875 | Mitotic Prophase | 7.604321e-01 | 0.119 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 7.628228e-01 | 0.118 |
| R-HSA-112316 | Neuronal System | 7.653729e-01 | 0.116 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.655085e-01 | 0.116 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.655085e-01 | 0.116 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.704781e-01 | 0.113 |
| R-HSA-114608 | Platelet degranulation | 7.801051e-01 | 0.108 |
| R-HSA-421270 | Cell-cell junction organization | 7.844128e-01 | 0.105 |
| R-HSA-8956319 | Nucleotide catabolism | 7.847670e-01 | 0.105 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 7.915763e-01 | 0.102 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.928906e-01 | 0.101 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.937981e-01 | 0.100 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.937981e-01 | 0.100 |
| R-HSA-9909396 | Circadian clock | 7.937981e-01 | 0.100 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.959964e-01 | 0.099 |
| R-HSA-163685 | Integration of energy metabolism | 8.045589e-01 | 0.094 |
| R-HSA-416476 | G alpha (q) signalling events | 8.058470e-01 | 0.094 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.066431e-01 | 0.093 |
| R-HSA-5368287 | Mitochondrial translation | 8.087052e-01 | 0.092 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.087052e-01 | 0.092 |
| R-HSA-8953854 | Metabolism of RNA | 8.087187e-01 | 0.092 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.299948e-01 | 0.081 |
| R-HSA-166520 | Signaling by NTRKs | 8.299948e-01 | 0.081 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.310225e-01 | 0.080 |
| R-HSA-9658195 | Leishmania infection | 8.310225e-01 | 0.080 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.405965e-01 | 0.075 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.456482e-01 | 0.073 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.472965e-01 | 0.072 |
| R-HSA-195721 | Signaling by WNT | 8.532337e-01 | 0.069 |
| R-HSA-422475 | Axon guidance | 8.544718e-01 | 0.068 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.568251e-01 | 0.067 |
| R-HSA-72766 | Translation | 8.591759e-01 | 0.066 |
| R-HSA-597592 | Post-translational protein modification | 8.630588e-01 | 0.064 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.700207e-01 | 0.060 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.714101e-01 | 0.060 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.714101e-01 | 0.060 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.714101e-01 | 0.060 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.741448e-01 | 0.058 |
| R-HSA-5663205 | Infectious disease | 8.801583e-01 | 0.055 |
| R-HSA-2559583 | Cellular Senescence | 8.807311e-01 | 0.055 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.835839e-01 | 0.054 |
| R-HSA-6798695 | Neutrophil degranulation | 8.852968e-01 | 0.053 |
| R-HSA-3781865 | Diseases of glycosylation | 8.857525e-01 | 0.053 |
| R-HSA-9675108 | Nervous system development | 8.859811e-01 | 0.053 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.905637e-01 | 0.050 |
| R-HSA-983712 | Ion channel transport | 8.917347e-01 | 0.050 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.038216e-01 | 0.044 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.068785e-01 | 0.042 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.068785e-01 | 0.042 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.068785e-01 | 0.042 |
| R-HSA-199991 | Membrane Trafficking | 9.277088e-01 | 0.033 |
| R-HSA-162906 | HIV Infection | 9.288704e-01 | 0.032 |
| R-HSA-72312 | rRNA processing | 9.326049e-01 | 0.030 |
| R-HSA-5688426 | Deubiquitination | 9.474235e-01 | 0.023 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.571855e-01 | 0.019 |
| R-HSA-1266738 | Developmental Biology | 9.640505e-01 | 0.016 |
| R-HSA-1483257 | Phospholipid metabolism | 9.658905e-01 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 9.715399e-01 | 0.013 |
| R-HSA-168256 | Immune System | 9.721841e-01 | 0.012 |
| R-HSA-109582 | Hemostasis | 9.736508e-01 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 9.769143e-01 | 0.010 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.778627e-01 | 0.010 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.781369e-01 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.792899e-01 | 0.009 |
| R-HSA-211859 | Biological oxidations | 9.804302e-01 | 0.009 |
| R-HSA-392499 | Metabolism of proteins | 9.811645e-01 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 9.851694e-01 | 0.006 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.866516e-01 | 0.006 |
| R-HSA-2262752 | Cellular responses to stress | 9.874288e-01 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.879794e-01 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 9.900131e-01 | 0.004 |
| R-HSA-8978868 | Fatty acid metabolism | 9.900131e-01 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.915213e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.919719e-01 | 0.004 |
| R-HSA-449147 | Signaling by Interleukins | 9.925813e-01 | 0.003 |
| R-HSA-168249 | Innate Immune System | 9.966842e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.990160e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.997909e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999859e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999991e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999994e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.867 | 0.798 | 1 | 0.896 |
CDK1 |
0.853 | 0.775 | 1 | 0.885 |
CDK5 |
0.850 | 0.743 | 1 | 0.865 |
CDK18 |
0.848 | 0.706 | 1 | 0.888 |
CDK17 |
0.847 | 0.719 | 1 | 0.894 |
CDK19 |
0.844 | 0.678 | 1 | 0.883 |
CDK16 |
0.844 | 0.712 | 1 | 0.893 |
CDK7 |
0.844 | 0.673 | 1 | 0.884 |
KIS |
0.843 | 0.608 | 1 | 0.867 |
CDK8 |
0.842 | 0.677 | 1 | 0.871 |
CDK2 |
0.840 | 0.718 | 1 | 0.815 |
P38G |
0.840 | 0.719 | 1 | 0.896 |
CLK3 |
0.840 | 0.516 | 1 | 0.717 |
HIPK2 |
0.839 | 0.637 | 1 | 0.864 |
ERK1 |
0.838 | 0.700 | 1 | 0.878 |
CDK13 |
0.836 | 0.673 | 1 | 0.893 |
CDK14 |
0.834 | 0.689 | 1 | 0.872 |
P38B |
0.834 | 0.695 | 1 | 0.871 |
NLK |
0.833 | 0.655 | 1 | 0.727 |
CDK12 |
0.833 | 0.670 | 1 | 0.899 |
CDK10 |
0.832 | 0.658 | 1 | 0.877 |
JNK2 |
0.832 | 0.706 | 1 | 0.899 |
P38D |
0.830 | 0.696 | 1 | 0.909 |
P38A |
0.830 | 0.680 | 1 | 0.835 |
CDK6 |
0.830 | 0.705 | 1 | 0.879 |
ERK2 |
0.828 | 0.696 | 1 | 0.860 |
CDK4 |
0.827 | 0.692 | 1 | 0.902 |
DYRK2 |
0.827 | 0.599 | 1 | 0.830 |
JNK3 |
0.826 | 0.693 | 1 | 0.895 |
HIPK1 |
0.826 | 0.579 | 1 | 0.819 |
CDK9 |
0.826 | 0.643 | 1 | 0.889 |
HIPK4 |
0.825 | 0.394 | 1 | 0.697 |
SRPK1 |
0.820 | 0.292 | -3 | 0.726 |
ERK5 |
0.818 | 0.347 | 1 | 0.633 |
DYRK1A |
0.818 | 0.508 | 1 | 0.830 |
HIPK3 |
0.818 | 0.555 | 1 | 0.798 |
CLK1 |
0.817 | 0.399 | -3 | 0.734 |
DYRK1B |
0.817 | 0.586 | 1 | 0.859 |
DYRK4 |
0.816 | 0.600 | 1 | 0.884 |
MTOR |
0.815 | 0.258 | 1 | 0.556 |
CDKL5 |
0.814 | 0.193 | -3 | 0.765 |
SRPK2 |
0.813 | 0.239 | -3 | 0.649 |
ICK |
0.812 | 0.346 | -3 | 0.811 |
CDKL1 |
0.811 | 0.182 | -3 | 0.772 |
CLK4 |
0.809 | 0.345 | -3 | 0.746 |
COT |
0.808 | 0.008 | 2 | 0.865 |
MAK |
0.806 | 0.466 | -2 | 0.817 |
MST4 |
0.806 | 0.120 | 2 | 0.867 |
JNK1 |
0.804 | 0.615 | 1 | 0.901 |
DYRK3 |
0.803 | 0.442 | 1 | 0.787 |
CLK2 |
0.803 | 0.347 | -3 | 0.730 |
MOS |
0.801 | 0.024 | 1 | 0.493 |
CDC7 |
0.801 | -0.076 | 1 | 0.461 |
PKCD |
0.800 | 0.105 | 2 | 0.835 |
PRPK |
0.799 | -0.060 | -1 | 0.877 |
SRPK3 |
0.798 | 0.194 | -3 | 0.692 |
PKN3 |
0.797 | 0.012 | -3 | 0.800 |
MOK |
0.797 | 0.420 | 1 | 0.720 |
PRP4 |
0.796 | 0.375 | -3 | 0.720 |
NEK6 |
0.796 | 0.010 | -2 | 0.825 |
NUAK2 |
0.796 | 0.045 | -3 | 0.822 |
ULK2 |
0.796 | -0.088 | 2 | 0.826 |
RAF1 |
0.795 | -0.110 | 1 | 0.436 |
TBK1 |
0.795 | -0.124 | 1 | 0.384 |
PIM3 |
0.794 | -0.016 | -3 | 0.805 |
PKN2 |
0.794 | 0.029 | -3 | 0.808 |
GCN2 |
0.794 | -0.143 | 2 | 0.815 |
PRKD2 |
0.794 | 0.030 | -3 | 0.759 |
NDR2 |
0.794 | -0.029 | -3 | 0.811 |
WNK1 |
0.794 | -0.013 | -2 | 0.880 |
CHAK2 |
0.793 | 0.027 | -1 | 0.843 |
ATR |
0.792 | -0.039 | 1 | 0.457 |
CAMK1B |
0.792 | -0.037 | -3 | 0.835 |
NIK |
0.792 | 0.017 | -3 | 0.850 |
NDR1 |
0.791 | -0.028 | -3 | 0.805 |
MLK3 |
0.791 | 0.095 | 2 | 0.791 |
PRKD1 |
0.791 | -0.023 | -3 | 0.803 |
BMPR2 |
0.790 | -0.118 | -2 | 0.843 |
DSTYK |
0.790 | -0.073 | 2 | 0.868 |
PKCA |
0.790 | 0.085 | 2 | 0.785 |
IKKE |
0.790 | -0.142 | 1 | 0.386 |
AMPKA1 |
0.789 | -0.027 | -3 | 0.826 |
NEK7 |
0.789 | -0.080 | -3 | 0.841 |
IRE1 |
0.789 | -0.008 | 1 | 0.373 |
PDHK4 |
0.788 | -0.215 | 1 | 0.487 |
MLK1 |
0.788 | -0.028 | 2 | 0.844 |
PKCG |
0.788 | 0.071 | 2 | 0.788 |
RSK3 |
0.788 | -0.010 | -3 | 0.748 |
CAMLCK |
0.788 | -0.013 | -2 | 0.839 |
PDHK1 |
0.787 | -0.175 | 1 | 0.468 |
PKCB |
0.787 | 0.074 | 2 | 0.789 |
IRE2 |
0.787 | 0.011 | 2 | 0.808 |
TGFBR2 |
0.787 | -0.074 | -2 | 0.733 |
ERK7 |
0.787 | 0.234 | 2 | 0.549 |
RSK2 |
0.786 | -0.007 | -3 | 0.752 |
WNK3 |
0.786 | -0.137 | 1 | 0.411 |
PIM1 |
0.785 | 0.035 | -3 | 0.749 |
MARK4 |
0.785 | -0.053 | 4 | 0.797 |
P90RSK |
0.785 | -0.016 | -3 | 0.756 |
MNK2 |
0.785 | 0.016 | -2 | 0.792 |
PRKD3 |
0.784 | 0.014 | -3 | 0.737 |
NIM1 |
0.784 | -0.034 | 3 | 0.692 |
DAPK2 |
0.784 | -0.043 | -3 | 0.843 |
AMPKA2 |
0.784 | -0.025 | -3 | 0.797 |
RIPK3 |
0.783 | -0.135 | 3 | 0.681 |
PHKG1 |
0.783 | -0.011 | -3 | 0.799 |
NUAK1 |
0.783 | -0.005 | -3 | 0.776 |
CHAK1 |
0.783 | 0.020 | 2 | 0.842 |
IKKB |
0.783 | -0.175 | -2 | 0.725 |
P70S6KB |
0.782 | -0.007 | -3 | 0.773 |
PKCH |
0.782 | 0.049 | 2 | 0.779 |
AURC |
0.782 | 0.015 | -2 | 0.662 |
ULK1 |
0.782 | -0.125 | -3 | 0.807 |
NEK9 |
0.782 | -0.101 | 2 | 0.865 |
TSSK1 |
0.782 | -0.030 | -3 | 0.846 |
SKMLCK |
0.782 | -0.064 | -2 | 0.852 |
PKACG |
0.781 | -0.024 | -2 | 0.754 |
PKCZ |
0.781 | 0.034 | 2 | 0.821 |
TSSK2 |
0.781 | -0.056 | -5 | 0.829 |
MNK1 |
0.781 | 0.034 | -2 | 0.800 |
MLK2 |
0.780 | -0.076 | 2 | 0.857 |
MAPKAPK3 |
0.779 | -0.063 | -3 | 0.760 |
BCKDK |
0.779 | -0.148 | -1 | 0.854 |
AKT2 |
0.778 | 0.054 | -3 | 0.675 |
PAK6 |
0.778 | 0.009 | -2 | 0.707 |
PINK1 |
0.778 | 0.192 | 1 | 0.562 |
CAMK2G |
0.778 | -0.148 | 2 | 0.784 |
QIK |
0.777 | -0.062 | -3 | 0.817 |
QSK |
0.777 | -0.022 | 4 | 0.790 |
NEK2 |
0.777 | -0.057 | 2 | 0.849 |
HUNK |
0.776 | -0.172 | 2 | 0.819 |
PKCT |
0.776 | 0.047 | 2 | 0.790 |
PKR |
0.776 | -0.006 | 1 | 0.423 |
PAK3 |
0.775 | -0.066 | -2 | 0.780 |
PKG2 |
0.775 | 0.006 | -2 | 0.693 |
MELK |
0.775 | -0.061 | -3 | 0.786 |
PHKG2 |
0.775 | 0.007 | -3 | 0.781 |
LATS2 |
0.774 | -0.077 | -5 | 0.737 |
MPSK1 |
0.774 | 0.098 | 1 | 0.412 |
SIK |
0.774 | -0.023 | -3 | 0.744 |
SGK3 |
0.774 | 0.008 | -3 | 0.739 |
MASTL |
0.774 | -0.220 | -2 | 0.797 |
PAK1 |
0.774 | -0.048 | -2 | 0.786 |
AKT1 |
0.773 | 0.046 | -3 | 0.694 |
MST3 |
0.773 | 0.090 | 2 | 0.861 |
ANKRD3 |
0.773 | -0.157 | 1 | 0.424 |
MAPKAPK2 |
0.773 | -0.043 | -3 | 0.709 |
GRK5 |
0.772 | -0.203 | -3 | 0.797 |
AURB |
0.772 | -0.011 | -2 | 0.658 |
DNAPK |
0.772 | -0.036 | 1 | 0.428 |
IRAK4 |
0.772 | -0.019 | 1 | 0.368 |
IKKA |
0.772 | -0.111 | -2 | 0.716 |
RSK4 |
0.772 | -0.001 | -3 | 0.721 |
MLK4 |
0.772 | -0.011 | 2 | 0.763 |
ATM |
0.772 | -0.079 | 1 | 0.419 |
CAMK4 |
0.772 | -0.110 | -3 | 0.794 |
PIM2 |
0.771 | 0.024 | -3 | 0.727 |
PKCE |
0.771 | 0.106 | 2 | 0.779 |
VRK2 |
0.771 | -0.010 | 1 | 0.500 |
LATS1 |
0.771 | -0.015 | -3 | 0.833 |
GRK7 |
0.771 | 0.009 | 1 | 0.427 |
PKACB |
0.771 | 0.012 | -2 | 0.682 |
RIPK1 |
0.770 | -0.221 | 1 | 0.379 |
DLK |
0.770 | -0.189 | 1 | 0.419 |
GRK1 |
0.770 | -0.067 | -2 | 0.761 |
TAO3 |
0.770 | 0.099 | 1 | 0.426 |
YSK4 |
0.770 | -0.098 | 1 | 0.390 |
BMPR1B |
0.769 | -0.049 | 1 | 0.400 |
PKCI |
0.769 | 0.043 | 2 | 0.787 |
SMG1 |
0.768 | -0.077 | 1 | 0.428 |
MSK2 |
0.768 | -0.061 | -3 | 0.714 |
BRSK2 |
0.767 | -0.093 | -3 | 0.798 |
MEK1 |
0.767 | -0.126 | 2 | 0.844 |
WNK4 |
0.767 | -0.067 | -2 | 0.878 |
ALK4 |
0.767 | -0.101 | -2 | 0.768 |
MARK3 |
0.767 | -0.044 | 4 | 0.756 |
ZAK |
0.766 | -0.046 | 1 | 0.382 |
TTBK2 |
0.766 | -0.198 | 2 | 0.732 |
PRKX |
0.766 | 0.034 | -3 | 0.667 |
CAMK2D |
0.766 | -0.160 | -3 | 0.818 |
SNRK |
0.766 | -0.133 | 2 | 0.731 |
BRSK1 |
0.766 | -0.078 | -3 | 0.775 |
GRK6 |
0.766 | -0.174 | 1 | 0.427 |
TNIK |
0.766 | 0.163 | 3 | 0.856 |
TAO2 |
0.766 | 0.076 | 2 | 0.882 |
PAK2 |
0.765 | -0.080 | -2 | 0.768 |
MEKK1 |
0.765 | -0.081 | 1 | 0.404 |
DCAMKL1 |
0.765 | -0.020 | -3 | 0.772 |
HRI |
0.765 | -0.094 | -2 | 0.800 |
MYLK4 |
0.764 | -0.058 | -2 | 0.760 |
NEK5 |
0.764 | -0.061 | 1 | 0.396 |
MARK2 |
0.763 | -0.063 | 4 | 0.709 |
PLK4 |
0.763 | -0.103 | 2 | 0.671 |
PKN1 |
0.763 | 0.007 | -3 | 0.711 |
CHK1 |
0.763 | -0.083 | -3 | 0.803 |
TGFBR1 |
0.763 | -0.104 | -2 | 0.732 |
MEK5 |
0.762 | -0.094 | 2 | 0.850 |
SSTK |
0.762 | -0.046 | 4 | 0.789 |
MEKK2 |
0.762 | -0.029 | 2 | 0.837 |
HGK |
0.762 | 0.088 | 3 | 0.830 |
AKT3 |
0.760 | 0.041 | -3 | 0.611 |
CAMK1G |
0.760 | -0.063 | -3 | 0.742 |
DRAK1 |
0.760 | -0.125 | 1 | 0.361 |
PLK1 |
0.760 | -0.163 | -2 | 0.769 |
DCAMKL2 |
0.760 | -0.034 | -3 | 0.801 |
PERK |
0.759 | -0.134 | -2 | 0.785 |
BRAF |
0.759 | -0.099 | -4 | 0.714 |
GSK3A |
0.759 | 0.113 | 4 | 0.319 |
BUB1 |
0.759 | 0.070 | -5 | 0.770 |
MARK1 |
0.759 | -0.085 | 4 | 0.775 |
GRK4 |
0.759 | -0.208 | -2 | 0.782 |
AURA |
0.759 | -0.036 | -2 | 0.619 |
NEK11 |
0.759 | -0.047 | 1 | 0.418 |
MSK1 |
0.758 | -0.058 | -3 | 0.721 |
ACVR2B |
0.758 | -0.117 | -2 | 0.734 |
SMMLCK |
0.758 | -0.036 | -3 | 0.791 |
ACVR2A |
0.758 | -0.117 | -2 | 0.717 |
NEK4 |
0.758 | -0.036 | 1 | 0.384 |
MAP3K15 |
0.757 | -0.001 | 1 | 0.389 |
MEKK6 |
0.757 | -0.006 | 1 | 0.395 |
P70S6K |
0.757 | -0.034 | -3 | 0.687 |
MINK |
0.757 | 0.055 | 1 | 0.393 |
PKACA |
0.757 | -0.002 | -2 | 0.632 |
EEF2K |
0.757 | 0.069 | 3 | 0.822 |
KHS1 |
0.757 | 0.077 | 1 | 0.412 |
CAMK2A |
0.757 | -0.086 | 2 | 0.750 |
NEK8 |
0.756 | -0.056 | 2 | 0.858 |
TLK2 |
0.756 | -0.153 | 1 | 0.392 |
GCK |
0.756 | 0.043 | 1 | 0.417 |
FAM20C |
0.756 | -0.068 | 2 | 0.522 |
KHS2 |
0.755 | 0.101 | 1 | 0.424 |
LKB1 |
0.755 | -0.030 | -3 | 0.822 |
LOK |
0.754 | 0.018 | -2 | 0.762 |
PDK1 |
0.754 | -0.050 | 1 | 0.436 |
CAMK2B |
0.754 | -0.126 | 2 | 0.722 |
MEKK3 |
0.754 | -0.140 | 1 | 0.397 |
ALK2 |
0.754 | -0.118 | -2 | 0.744 |
MAPKAPK5 |
0.754 | -0.124 | -3 | 0.697 |
PAK5 |
0.753 | -0.041 | -2 | 0.635 |
HPK1 |
0.752 | 0.019 | 1 | 0.415 |
SGK1 |
0.752 | 0.034 | -3 | 0.590 |
LRRK2 |
0.752 | 0.035 | 2 | 0.867 |
NEK1 |
0.751 | -0.035 | 1 | 0.376 |
YSK1 |
0.750 | 0.014 | 2 | 0.846 |
MRCKB |
0.750 | 0.008 | -3 | 0.718 |
CK1E |
0.749 | -0.066 | -3 | 0.476 |
GRK2 |
0.749 | -0.117 | -2 | 0.672 |
PAK4 |
0.749 | -0.039 | -2 | 0.637 |
BMPR1A |
0.749 | -0.080 | 1 | 0.394 |
CHK2 |
0.749 | -0.009 | -3 | 0.625 |
GAK |
0.749 | -0.029 | 1 | 0.441 |
CAMKK1 |
0.748 | -0.119 | -2 | 0.748 |
MST2 |
0.748 | -0.040 | 1 | 0.409 |
HASPIN |
0.748 | 0.055 | -1 | 0.704 |
TLK1 |
0.748 | -0.173 | -2 | 0.763 |
PLK3 |
0.748 | -0.168 | 2 | 0.742 |
IRAK1 |
0.748 | -0.188 | -1 | 0.787 |
SBK |
0.748 | 0.069 | -3 | 0.563 |
CAMK1D |
0.748 | -0.053 | -3 | 0.680 |
ROCK2 |
0.747 | 0.007 | -3 | 0.763 |
DAPK3 |
0.747 | -0.042 | -3 | 0.778 |
MRCKA |
0.747 | 0.001 | -3 | 0.734 |
GSK3B |
0.746 | -0.021 | 4 | 0.312 |
PBK |
0.746 | -0.021 | 1 | 0.397 |
MST1 |
0.746 | -0.015 | 1 | 0.394 |
PASK |
0.745 | -0.082 | -3 | 0.821 |
SLK |
0.744 | -0.015 | -2 | 0.701 |
CAMKK2 |
0.744 | -0.119 | -2 | 0.747 |
TTBK1 |
0.743 | -0.177 | 2 | 0.658 |
TAO1 |
0.742 | 0.050 | 1 | 0.376 |
NEK3 |
0.742 | -0.065 | 1 | 0.382 |
MYO3B |
0.742 | 0.076 | 2 | 0.866 |
CAMK1A |
0.742 | -0.033 | -3 | 0.642 |
MYO3A |
0.742 | 0.105 | 1 | 0.397 |
CK1D |
0.740 | -0.053 | -3 | 0.425 |
DMPK1 |
0.740 | 0.030 | -3 | 0.740 |
TAK1 |
0.740 | -0.100 | 1 | 0.412 |
RIPK2 |
0.739 | -0.178 | 1 | 0.359 |
MEK2 |
0.738 | -0.144 | 2 | 0.835 |
VRK1 |
0.737 | -0.148 | 2 | 0.863 |
CK1G1 |
0.737 | -0.111 | -3 | 0.477 |
ROCK1 |
0.736 | 0.001 | -3 | 0.728 |
STK33 |
0.736 | -0.110 | 2 | 0.642 |
LIMK2_TYR |
0.736 | 0.163 | -3 | 0.861 |
DAPK1 |
0.735 | -0.067 | -3 | 0.756 |
PDHK3_TYR |
0.735 | 0.090 | 4 | 0.817 |
PKG1 |
0.734 | -0.041 | -2 | 0.609 |
ASK1 |
0.734 | -0.037 | 1 | 0.389 |
CK1A2 |
0.733 | -0.080 | -3 | 0.424 |
BIKE |
0.733 | -0.015 | 1 | 0.381 |
TTK |
0.733 | -0.020 | -2 | 0.771 |
TESK1_TYR |
0.733 | 0.082 | 3 | 0.796 |
CK2A2 |
0.733 | -0.090 | 1 | 0.372 |
OSR1 |
0.732 | 0.016 | 2 | 0.819 |
CRIK |
0.731 | 0.002 | -3 | 0.688 |
PKMYT1_TYR |
0.731 | 0.116 | 3 | 0.773 |
GRK3 |
0.728 | -0.134 | -2 | 0.625 |
AAK1 |
0.726 | 0.019 | 1 | 0.345 |
LIMK1_TYR |
0.726 | 0.066 | 2 | 0.886 |
PINK1_TYR |
0.725 | 0.010 | 1 | 0.458 |
MAP2K4_TYR |
0.725 | -0.018 | -1 | 0.909 |
PDHK4_TYR |
0.724 | -0.001 | 2 | 0.870 |
MAP2K7_TYR |
0.723 | -0.088 | 2 | 0.873 |
ROS1 |
0.723 | -0.027 | 3 | 0.717 |
CK2A1 |
0.721 | -0.106 | 1 | 0.358 |
TYK2 |
0.721 | -0.082 | 1 | 0.416 |
CSF1R |
0.720 | -0.029 | 3 | 0.744 |
MAP2K6_TYR |
0.720 | -0.038 | -1 | 0.907 |
JAK2 |
0.720 | -0.061 | 1 | 0.433 |
MST1R |
0.719 | -0.077 | 3 | 0.744 |
TYRO3 |
0.719 | -0.067 | 3 | 0.747 |
PLK2 |
0.719 | -0.114 | -3 | 0.753 |
TNNI3K_TYR |
0.719 | 0.032 | 1 | 0.419 |
RET |
0.718 | -0.115 | 1 | 0.422 |
BMPR2_TYR |
0.718 | -0.026 | -1 | 0.892 |
JAK1 |
0.717 | -0.010 | 1 | 0.391 |
NEK10_TYR |
0.717 | -0.030 | 1 | 0.376 |
EPHA6 |
0.717 | -0.063 | -1 | 0.858 |
ALPHAK3 |
0.716 | -0.070 | -1 | 0.788 |
PDHK1_TYR |
0.715 | -0.099 | -1 | 0.898 |
TNK1 |
0.715 | -0.026 | 3 | 0.723 |
ABL2 |
0.713 | -0.061 | -1 | 0.804 |
JAK3 |
0.712 | -0.074 | 1 | 0.408 |
EPHB4 |
0.711 | -0.113 | -1 | 0.848 |
KDR |
0.711 | -0.042 | 3 | 0.707 |
ABL1 |
0.710 | -0.078 | -1 | 0.796 |
LCK |
0.709 | -0.030 | -1 | 0.811 |
WEE1_TYR |
0.709 | 0.015 | -1 | 0.775 |
YES1 |
0.708 | -0.078 | -1 | 0.827 |
DDR1 |
0.708 | -0.149 | 4 | 0.760 |
TXK |
0.708 | -0.061 | 1 | 0.402 |
FLT3 |
0.707 | -0.095 | 3 | 0.749 |
PDGFRB |
0.707 | -0.138 | 3 | 0.746 |
TEK |
0.707 | -0.042 | 3 | 0.682 |
HCK |
0.707 | -0.092 | -1 | 0.818 |
TNK2 |
0.706 | -0.120 | 3 | 0.691 |
BLK |
0.706 | -0.036 | -1 | 0.814 |
FGFR1 |
0.706 | -0.071 | 3 | 0.682 |
PDGFRA |
0.705 | -0.135 | 3 | 0.760 |
YANK3 |
0.704 | -0.087 | 2 | 0.396 |
STLK3 |
0.704 | -0.171 | 1 | 0.364 |
FGFR2 |
0.704 | -0.093 | 3 | 0.693 |
KIT |
0.704 | -0.107 | 3 | 0.740 |
INSRR |
0.703 | -0.135 | 3 | 0.668 |
ITK |
0.702 | -0.107 | -1 | 0.812 |
FGR |
0.702 | -0.158 | 1 | 0.394 |
FER |
0.700 | -0.188 | 1 | 0.439 |
AXL |
0.699 | -0.161 | 3 | 0.696 |
MERTK |
0.699 | -0.136 | 3 | 0.698 |
TEC |
0.698 | -0.095 | -1 | 0.741 |
ALK |
0.698 | -0.136 | 3 | 0.651 |
FRK |
0.698 | -0.088 | -1 | 0.826 |
MET |
0.698 | -0.107 | 3 | 0.716 |
BTK |
0.697 | -0.143 | -1 | 0.783 |
EPHA4 |
0.697 | -0.122 | 2 | 0.735 |
EPHB1 |
0.696 | -0.184 | 1 | 0.409 |
EPHB3 |
0.695 | -0.169 | -1 | 0.831 |
DDR2 |
0.695 | -0.065 | 3 | 0.654 |
EPHA1 |
0.694 | -0.143 | 3 | 0.695 |
CK1A |
0.694 | -0.108 | -3 | 0.336 |
EPHB2 |
0.694 | -0.163 | -1 | 0.821 |
LTK |
0.693 | -0.155 | 3 | 0.675 |
FGFR3 |
0.692 | -0.099 | 3 | 0.673 |
FLT4 |
0.692 | -0.140 | 3 | 0.691 |
SRMS |
0.692 | -0.220 | 1 | 0.412 |
FLT1 |
0.691 | -0.122 | -1 | 0.845 |
LYN |
0.691 | -0.110 | 3 | 0.679 |
ERBB2 |
0.691 | -0.157 | 1 | 0.397 |
FYN |
0.690 | -0.079 | -1 | 0.783 |
INSR |
0.690 | -0.150 | 3 | 0.655 |
BMX |
0.690 | -0.122 | -1 | 0.716 |
NTRK2 |
0.690 | -0.183 | 3 | 0.694 |
EPHA7 |
0.689 | -0.145 | 2 | 0.751 |
MUSK |
0.689 | -0.094 | 1 | 0.316 |
PTK6 |
0.687 | -0.190 | -1 | 0.743 |
MATK |
0.687 | -0.086 | -1 | 0.726 |
NTRK1 |
0.685 | -0.235 | -1 | 0.834 |
EPHA3 |
0.683 | -0.179 | 2 | 0.727 |
NTRK3 |
0.683 | -0.163 | -1 | 0.782 |
PTK2B |
0.682 | -0.152 | -1 | 0.761 |
SRC |
0.680 | -0.126 | -1 | 0.779 |
EPHA8 |
0.679 | -0.130 | -1 | 0.804 |
EGFR |
0.678 | -0.128 | 1 | 0.345 |
CSK |
0.677 | -0.151 | 2 | 0.766 |
EPHA5 |
0.677 | -0.163 | 2 | 0.721 |
YANK2 |
0.674 | -0.098 | 2 | 0.409 |
FGFR4 |
0.673 | -0.133 | -1 | 0.771 |
CK1G3 |
0.672 | -0.113 | -3 | 0.292 |
PTK2 |
0.672 | -0.083 | -1 | 0.794 |
IGF1R |
0.671 | -0.149 | 3 | 0.598 |
SYK |
0.669 | -0.103 | -1 | 0.774 |
ERBB4 |
0.668 | -0.114 | 1 | 0.358 |
EPHA2 |
0.667 | -0.159 | -1 | 0.778 |
ZAP70 |
0.659 | -0.070 | -1 | 0.700 |
FES |
0.655 | -0.173 | -1 | 0.694 |
CK1G2 |
0.648 | -0.120 | -3 | 0.389 |