Motif 307 (n=162)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L020 | MEX3A | S432 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A6NCL7 | ANKRD33B | S416 | ochoa | Ankyrin repeat domain-containing protein 33B | None |
| A6NEL2 | SOWAHB | S268 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A6NIX2 | WTIP | S171 | ochoa | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| E9PAV3 | NACA | S1429 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00515 | LAD1 | S298 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14976 | GAK | S778 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S804 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15027 | SEC16A | S1801 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15055 | PER2 | S627 | ochoa | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15061 | SYNM | S1211 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15503 | INSIG1 | S43 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43166 | SIPA1L1 | S381 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43248 | HOXC11 | S211 | ochoa | Homeobox protein Hox-C11 (Homeobox protein Hox-3H) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. |
| O43639 | NCK2 | S276 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O43918 | AIRE | S156 | psp | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity). {ECO:0000250|UniProtKB:Q9Z0E3, ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:18292755, ECO:0000269|PubMed:26084028, ECO:0000305|PubMed:19302042, ECO:0000305|PubMed:26972725}. |
| O60347 | TBC1D12 | S113 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O60347 | TBC1D12 | S115 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O60828 | PQBP1 | S247 | ochoa|psp | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| O75147 | OBSL1 | S232 | ochoa | Obscurin-like protein 1 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| O75533 | SF3B1 | S259 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75781 | PALM | S124 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O75781 | PALM | S138 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O94819 | KBTBD11 | S316 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O95049 | TJP3 | S565 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95319 | CELF2 | S203 | ochoa | CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3) | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250|UniProtKB:Q9Z0H4, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:11577082, ECO:0000269|PubMed:11931771, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15657417, ECO:0000269|PubMed:15894795, ECO:0000269|PubMed:28431233}. |
| O95696 | BRD1 | S128 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95758 | PTBP3 | S165 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O95785 | WIZ | S1309 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95793 | STAU1 | S465 | ochoa | Double-stranded RNA-binding protein Staufen homolog 1 | Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; FUNCTION: (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. {ECO:0000269|PubMed:10325410, ECO:0000269|PubMed:18498651, ECO:0000269|PubMed:23926355, ECO:0000269|PubMed:30301857}. |
| P00519 | ABL1 | S659 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P06576 | ATP5F1B | S51 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P09017 | HOXC4 | S243 | ochoa | Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P09211 | GSTP1 | S185 | psp | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P10746 | UROS | S245 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P11171 | EPB41 | S540 | ochoa|psp | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12755 | SKI | S432 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P16989 | YBX3 | S38 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17542 | TAL1 | S122 | ochoa|psp | T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5) | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}. |
| P17676 | CEBPB | S257 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P17677 | GAP43 | S203 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P18887 | XRCC1 | S219 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P25054 | APC | S747 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27694 | RPA1 | S149 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P28799 | GRN | S81 | psp | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:12526812, ECO:0000269|PubMed:18378771, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.; FUNCTION: [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000269|PubMed:12526812}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000269|PubMed:28453791}. |
| P30559 | OXTR | S261 | psp | Oxytocin receptor (OT-R) | Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
| P35713 | SOX18 | S61 | ochoa | Transcription factor SOX-18 | Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. {ECO:0000250|UniProtKB:P43680}. |
| P42704 | LRPPRC | S54 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P43403 | ZAP70 | S88 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46013 | MKI67 | S2793 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46109 | CRKL | S220 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P46459 | NSF | S569 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P48552 | NRIP1 | S256 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48634 | PRRC2A | S1314 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49757 | NUMB | S284 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P50219 | MNX1 | S79 | ochoa | Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) | Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250|UniProtKB:Q9QZW9}. |
| P50552 | VASP | S245 | ochoa | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P52701 | MSH6 | S41 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P55317 | FOXA1 | T341 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P78312 | FAM193A | S677 | ochoa | Protein FAM193A (Protein IT14) | None |
| Q02978 | SLC25A11 | S19 | ochoa | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) | Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity). {ECO:0000250|UniProtKB:P22292, ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:21448454}. |
| Q06945 | SOX4 | S348 | ochoa | Transcription factor SOX-4 | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}. |
| Q12906 | ILF3 | S506 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13148 | TARDBP | S333 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13310 | PABPC4 | S531 | ochoa | Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) | Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250|UniProtKB:P11940, ECO:0000269|PubMed:37009826, ECO:0000269|PubMed:8524242}. |
| Q13322 | GRB10 | S104 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13415 | ORC1 | S610 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13428 | TCOF1 | S583 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13459 | MYO9B | S2035 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q2QGD7 | ZXDC | T172 | ochoa | Zinc finger protein ZXDC (ZXD-like zinc finger protein) | Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:17696781}. |
| Q5T1J5 | CHCHD2P9 | S41 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q66K89 | E4F1 | S50 | ochoa | Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. |
| Q68DK7 | MSL1 | S205 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IBW4 | NCAPH2 | S282 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IBW4 | NCAPH2 | S288 | psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IBW4 | NCAPH2 | S319 | psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6P3S6 | FBXO42 | S393 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PGN9 | PSRC1 | S70 | ochoa|psp | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6PJG2 | MIDEAS | S346 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6W2J9 | BCOR | S177 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZN55 | ZNF574 | S728 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZRI6 | C15orf39 | S994 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRV2 | FAM83H | S411 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q7L3V2 | RTL10 | S34 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
| Q7Z2K8 | GPRIN1 | S914 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2T5 | TRMT1L | S66 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z2T5 | TRMT1L | S68 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q7Z2W4 | ZC3HAV1 | S280 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3B3 | KANSL1 | S27 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z624 | CAMKMT | S20 | ochoa | Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) | Catalyzes the trimethylation of 'Lys-116' in calmodulin. {ECO:0000269|PubMed:20975703}. |
| Q7Z6I6 | ARHGAP30 | S349 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6J0 | SH3RF1 | S666 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q86UU1 | PHLDB1 | S665 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86Y01 | DTX1 | S279 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Q8IV32 | CCDC71 | S144 | ochoa | Coiled-coil domain-containing protein 71 | None |
| Q8IX07 | ZFPM1 | S638 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8N3D4 | EHBP1L1 | S784 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3F8 | MICALL1 | S537 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N5H7 | SH2D3C | S446 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8ND56 | LSM14A | S216 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NEG4 | FAM83F | Y107 | ochoa | Protein FAM83F | None |
| Q8NFH8 | REPS2 | S241 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8NHG8 | ZNRF2 | S89 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TDD1 | DDX54 | S527 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8WVB6 | CHTF18 | S73 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
| Q8WVT3 | TRAPPC12 | S290 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WWM7 | ATXN2L | S111 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92585 | MAML1 | S932 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92667 | AKAP1 | S429 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92766 | RREB1 | S1225 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92879 | CELF1 | S179 | ochoa|psp | CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. |
| Q969V6 | MRTFA | S303 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AY4 | TTC28 | S2335 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96C12 | ARMC5 | S118 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96JM2 | ZNF462 | S1166 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96L91 | EP400 | S1547 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96L91 | EP400 | S2656 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96M11 | HYLS1 | S75 | ochoa | Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) | Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}. |
| Q96PK6 | RBM14 | S244 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q99611 | SEPHS2 | S31 | ochoa | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}. |
| Q99700 | ATXN2 | S744 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQI3 | EIF2AK1 | Y38 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000250|UniProtKB:Q9Z2R9, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:32197074, ECO:0000269|PubMed:37550454, ECO:0000269|PubMed:38340717}. |
| Q9BRG2 | SH2D3A | S179 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BSJ6 | PIMREG | S164 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BV73 | CEP250 | S2332 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BW04 | SARG | S429 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9H008 | LHPP | S191 | ochoa | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (hLHPP) (EC 3.1.3.-) (EC 3.6.1.1) | Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}. |
| Q9H0E3 | SAP130 | S300 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H116 | GZF1 | S180 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
| Q9H1I8 | ASCC2 | S707 | ochoa | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9H1K1 | ISCU | S20 | ochoa | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) | [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled (PubMed:34824239). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable) (PubMed:24971490, PubMed:29576242, PubMed:30031876, PubMed:34824239). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form (PubMed:23940031). May modulate NFS1 desulfurase activity in a zinc-dependent manner (PubMed:30031876). Modulates the interaction between FXN and the cysteine desulfurase complex (PubMed:29576242). {ECO:0000269|PubMed:23940031, ECO:0000269|PubMed:24971490, ECO:0000269|PubMed:29576242, ECO:0000269|PubMed:30031876, ECO:0000269|PubMed:34824239, ECO:0000305|PubMed:23940031}.; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. {ECO:0000269|PubMed:16517407, ECO:0000269|PubMed:16527810, ECO:0000269|PubMed:29309586}. |
| Q9H2W2 | MIXL1 | Y20 | psp | Homeobox protein MIXL1 (Homeodomain protein MIX) (hMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein) | Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}. |
| Q9H8N7 | ZNF395 | S449 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9H9J4 | USP42 | S863 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9H9J4 | USP42 | S1133 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HCM7 | FBRSL1 | S977 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQS7 | INCENP | S798 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NR12 | PDLIM7 | S247 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NZM4 | BICRA | S752 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P260 | RELCH | S93 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P275 | USP36 | S756 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UH62 | ARMCX3 | S110 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UKJ3 | GPATCH8 | S650 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKK3 | PARP4 | S1349 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULD9 | ZNF608 | S895 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9UMS4 | PRPF19 | S148 | ochoa | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250|UniProtKB:Q99KP6, ECO:0000250|UniProtKB:Q9JMJ4, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:15660529, ECO:0000269|PubMed:16223718, ECO:0000269|PubMed:16332694, ECO:0000269|PubMed:16388800, ECO:0000269|PubMed:17349974, ECO:0000269|PubMed:18263876, ECO:0000269|PubMed:21536736, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154, ECO:0000303|PubMed:17981804, ECO:0000303|PubMed:20595234}. |
| Q9UN79 | SOX13 | S77 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UQ35 | SRRM2 | S2310 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2376 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | Y2390 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB8 | BAIAP2 | S492 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y3L3 | SH3BP1 | T534 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3L3 | SH3BP1 | S536 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3S1 | WNK2 | S45 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4E6 | WDR7 | S1063 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y5V3 | MAGED1 | S129 | ochoa | Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. |
| Q9Y6H1 | CHCHD2 | S41 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| Q674X7 | KAZN | S318 | Sugiyama | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| P35408 | PTGER4 | S259 | ELM | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| O95071 | UBR5 | S1878 | Sugiyama | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O94776 | MTA2 | S496 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9H1R3 | MYLK2 | S107 | Sugiyama | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.000324 | 3.489 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.001144 | 2.942 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.010932 | 1.961 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.021745 | 1.663 |
| R-HSA-6791055 | TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | 0.032440 | 1.489 |
| R-HSA-6791462 | TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | 0.032440 | 1.489 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.043020 | 1.366 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.084199 | 1.075 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.094215 | 1.026 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.094215 | 1.026 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.104122 | 0.982 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.104122 | 0.982 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.113922 | 0.943 |
| R-HSA-8875656 | MET receptor recycling | 0.113922 | 0.943 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.133203 | 0.875 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.036092 | 1.443 |
| R-HSA-4839744 | Signaling by APC mutants | 0.142686 | 0.846 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.142686 | 0.846 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.142686 | 0.846 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.142686 | 0.846 |
| R-HSA-428540 | Activation of RAC1 | 0.152066 | 0.818 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.152066 | 0.818 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.152066 | 0.818 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.161345 | 0.792 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.161345 | 0.792 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.161345 | 0.792 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.161345 | 0.792 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.161345 | 0.792 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.161345 | 0.792 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.161345 | 0.792 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.170522 | 0.768 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.188577 | 0.725 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.188577 | 0.725 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.197458 | 0.705 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.206242 | 0.686 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.034249 | 1.465 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.223525 | 0.651 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.240433 | 0.619 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.119559 | 0.922 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.281119 | 0.551 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.145402 | 0.837 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.164501 | 0.784 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.319638 | 0.495 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.363160 | 0.440 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.087312 | 1.059 |
| R-HSA-72172 | mRNA Splicing | 0.102412 | 0.990 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.327091 | 0.485 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.248750 | 0.604 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.319638 | 0.495 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.069209 | 1.160 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.281119 | 0.551 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.288993 | 0.539 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.024827 | 1.605 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.188577 | 0.725 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.060223 | 1.220 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.022783 | 1.642 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.170522 | 0.768 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.179599 | 0.746 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.214931 | 0.668 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.232025 | 0.634 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.304483 | 0.516 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.161345 | 0.792 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.057306 | 1.242 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.064429 | 1.191 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.074072 | 1.130 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.069209 | 1.160 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.105374 | 0.977 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.244070 | 0.612 |
| R-HSA-3928664 | Ephrin signaling | 0.223525 | 0.651 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.235981 | 0.627 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.215839 | 0.666 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.066271 | 1.179 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.341756 | 0.466 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.123615 | 0.908 |
| R-HSA-5358508 | Mismatch Repair | 0.026943 | 1.570 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.048940 | 1.310 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.139086 | 0.857 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.032440 | 1.489 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.043020 | 1.366 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.084199 | 1.075 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.084199 | 1.075 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.152066 | 0.818 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.152066 | 0.818 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.170522 | 0.768 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.170522 | 0.768 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.265112 | 0.577 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.137900 | 0.860 |
| R-HSA-8949613 | Cristae formation | 0.304483 | 0.516 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.363160 | 0.440 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.403912 | 0.394 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.384205 | 0.415 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.161345 | 0.792 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.233732 | 0.631 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.348969 | 0.457 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.260277 | 0.585 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.101904 | 0.992 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.188577 | 0.725 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.304483 | 0.516 |
| R-HSA-1268020 | Mitochondrial protein import | 0.180081 | 0.745 |
| R-HSA-8875878 | MET promotes cell motility | 0.390625 | 0.408 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.363160 | 0.440 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.341756 | 0.466 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.397305 | 0.401 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.240433 | 0.619 |
| R-HSA-73942 | DNA Damage Reversal | 0.188577 | 0.725 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.360726 | 0.443 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.403912 | 0.394 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.403912 | 0.394 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.268387 | 0.571 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.098468 | 1.007 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.053484 | 1.272 |
| R-HSA-74713 | IRS activation | 0.074072 | 1.130 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 0.074072 | 1.130 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.104122 | 0.982 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.123615 | 0.908 |
| R-HSA-3214847 | HATs acetylate histones | 0.007732 | 2.112 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.223525 | 0.651 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.240433 | 0.619 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.081852 | 1.087 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.252170 | 0.598 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.268387 | 0.571 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.380317 | 0.420 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.319638 | 0.495 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.296780 | 0.528 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.211829 | 0.674 |
| R-HSA-9843745 | Adipogenesis | 0.220269 | 0.657 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.191907 | 0.717 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.316900 | 0.499 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.403487 | 0.394 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.252145 | 0.598 |
| R-HSA-5693538 | Homology Directed Repair | 0.178375 | 0.749 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.123615 | 0.908 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.013028 | 1.885 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.069209 | 1.160 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.232025 | 0.634 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.273159 | 0.564 |
| R-HSA-525793 | Myogenesis | 0.296780 | 0.528 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.304483 | 0.516 |
| R-HSA-180786 | Extension of Telomeres | 0.168373 | 0.774 |
| R-HSA-73894 | DNA Repair | 0.241471 | 0.617 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.248750 | 0.604 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.328936 | 0.483 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.249217 | 0.603 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.249217 | 0.603 |
| R-HSA-9664407 | Parasite infection | 0.249217 | 0.603 |
| R-HSA-69239 | Synthesis of DNA | 0.376418 | 0.424 |
| R-HSA-9909396 | Circadian clock | 0.223133 | 0.651 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.170522 | 0.768 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.197458 | 0.705 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.232025 | 0.634 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.334464 | 0.476 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.363160 | 0.440 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.397305 | 0.401 |
| R-HSA-202433 | Generation of second messenger molecules | 0.095065 | 1.022 |
| R-HSA-157579 | Telomere Maintenance | 0.332935 | 0.478 |
| R-HSA-170968 | Frs2-mediated activation | 0.170522 | 0.768 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.214931 | 0.668 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.327091 | 0.485 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.228887 | 0.640 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.141640 | 0.849 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.281119 | 0.551 |
| R-HSA-69190 | DNA strand elongation | 0.341756 | 0.466 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.403912 | 0.394 |
| R-HSA-186763 | Downstream signal transduction | 0.063171 | 1.199 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.029130 | 1.536 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.356340 | 0.448 |
| R-HSA-69206 | G1/S Transition | 0.200450 | 0.698 |
| R-HSA-169893 | Prolonged ERK activation events | 0.197458 | 0.705 |
| R-HSA-373753 | Nephrin family interactions | 0.240433 | 0.619 |
| R-HSA-202403 | TCR signaling | 0.388084 | 0.411 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.341756 | 0.466 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.290596 | 0.537 |
| R-HSA-2559583 | Cellular Senescence | 0.374205 | 0.427 |
| R-HSA-388479 | Vasopressin-like receptors | 0.063834 | 1.195 |
| R-HSA-74749 | Signal attenuation | 0.133203 | 0.875 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.179599 | 0.746 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.312102 | 0.506 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.319638 | 0.495 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.370139 | 0.432 |
| R-HSA-3371511 | HSF1 activation | 0.377043 | 0.424 |
| R-HSA-73884 | Base Excision Repair | 0.296740 | 0.528 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.085915 | 1.066 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.272442 | 0.565 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.286274 | 0.543 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.318745 | 0.497 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.123615 | 0.908 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.152066 | 0.818 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.223525 | 0.651 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.273159 | 0.564 |
| R-HSA-70635 | Urea cycle | 0.296780 | 0.528 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.348969 | 0.457 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.272442 | 0.565 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.142686 | 0.846 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.048940 | 1.310 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.170522 | 0.768 |
| R-HSA-8876725 | Protein methylation | 0.188577 | 0.725 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.348969 | 0.457 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.363160 | 0.440 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.108144 | 0.966 |
| R-HSA-9758941 | Gastrulation | 0.113497 | 0.945 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.188577 | 0.725 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.256975 | 0.590 |
| R-HSA-9865881 | Complex III assembly | 0.281119 | 0.551 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.288993 | 0.539 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.288993 | 0.539 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.390625 | 0.408 |
| R-HSA-71336 | Pentose phosphate pathway | 0.397305 | 0.401 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.403912 | 0.394 |
| R-HSA-186797 | Signaling by PDGF | 0.180081 | 0.745 |
| R-HSA-187687 | Signalling to ERKs | 0.370139 | 0.432 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.040044 | 1.397 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.040044 | 1.397 |
| R-HSA-381042 | PERK regulates gene expression | 0.370139 | 0.432 |
| R-HSA-9675135 | Diseases of DNA repair | 0.119559 | 0.922 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.370139 | 0.432 |
| R-HSA-4839726 | Chromatin organization | 0.030147 | 1.521 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.383103 | 0.417 |
| R-HSA-8853659 | RET signaling | 0.081817 | 1.087 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.062885 | 1.201 |
| R-HSA-422475 | Axon guidance | 0.284997 | 0.545 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.048940 | 1.310 |
| R-HSA-9675108 | Nervous system development | 0.344971 | 0.462 |
| R-HSA-1266738 | Developmental Biology | 0.185519 | 0.732 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.081817 | 1.087 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.232025 | 0.634 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.383871 | 0.416 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.166510 | 0.779 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.240433 | 0.619 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.003588 | 2.445 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.081817 | 1.087 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.256223 | 0.591 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.296780 | 0.528 |
| R-HSA-201451 | Signaling by BMP | 0.304483 | 0.516 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.293575 | 0.532 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.138198 | 0.859 |
| R-HSA-9694301 | Maturation of replicase proteins | 0.104122 | 0.982 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.311491 | 0.507 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.312102 | 0.506 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.370139 | 0.432 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.043267 | 1.364 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.075428 | 1.122 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.265112 | 0.577 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.043267 | 1.364 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.341756 | 0.466 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.300780 | 0.522 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.141640 | 0.849 |
| R-HSA-1640170 | Cell Cycle | 0.409282 | 0.388 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.410447 | 0.387 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.410447 | 0.387 |
| R-HSA-9607240 | FLT3 Signaling | 0.410447 | 0.387 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.414920 | 0.382 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.416912 | 0.380 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.416912 | 0.380 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.416912 | 0.380 |
| R-HSA-189451 | Heme biosynthesis | 0.416912 | 0.380 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.416912 | 0.380 |
| R-HSA-373760 | L1CAM interactions | 0.418707 | 0.378 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.422481 | 0.374 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.423305 | 0.373 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.423305 | 0.373 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.429629 | 0.367 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.429629 | 0.367 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.429992 | 0.367 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.435884 | 0.361 |
| R-HSA-69236 | G1 Phase | 0.435884 | 0.361 |
| R-HSA-73886 | Chromosome Maintenance | 0.437452 | 0.359 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.442071 | 0.355 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.448190 | 0.349 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.448190 | 0.349 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.448190 | 0.349 |
| R-HSA-75153 | Apoptotic execution phase | 0.448190 | 0.349 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.454242 | 0.343 |
| R-HSA-437239 | Recycling pathway of L1 | 0.454242 | 0.343 |
| R-HSA-194138 | Signaling by VEGF | 0.455867 | 0.341 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.455867 | 0.341 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.455867 | 0.341 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.455867 | 0.341 |
| R-HSA-69481 | G2/M Checkpoints | 0.463137 | 0.334 |
| R-HSA-73893 | DNA Damage Bypass | 0.466150 | 0.331 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.466150 | 0.331 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.472007 | 0.326 |
| R-HSA-2262752 | Cellular responses to stress | 0.472436 | 0.326 |
| R-HSA-912446 | Meiotic recombination | 0.477799 | 0.321 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.477799 | 0.321 |
| R-HSA-2514856 | The phototransduction cascade | 0.477799 | 0.321 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.483529 | 0.316 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.483529 | 0.316 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.489196 | 0.311 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.500345 | 0.301 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.500345 | 0.301 |
| R-HSA-9753281 | Paracetamol ADME | 0.500345 | 0.301 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.502079 | 0.299 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.505829 | 0.296 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.505829 | 0.296 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.505829 | 0.296 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.508964 | 0.293 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.516617 | 0.287 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.520000 | 0.284 |
| R-HSA-186712 | Regulation of beta-cell development | 0.521923 | 0.282 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.521923 | 0.282 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.527171 | 0.278 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.527171 | 0.278 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.527171 | 0.278 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.527171 | 0.278 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.527171 | 0.278 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.527171 | 0.278 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.527171 | 0.278 |
| R-HSA-156590 | Glutathione conjugation | 0.527171 | 0.278 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.529244 | 0.276 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.532361 | 0.274 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.537496 | 0.270 |
| R-HSA-9707616 | Heme signaling | 0.537496 | 0.270 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.542448 | 0.266 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.542574 | 0.266 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.542574 | 0.266 |
| R-HSA-69242 | S Phase | 0.545708 | 0.263 |
| R-HSA-157118 | Signaling by NOTCH | 0.545859 | 0.263 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.547596 | 0.262 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.552564 | 0.258 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.552564 | 0.258 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.557477 | 0.254 |
| R-HSA-69306 | DNA Replication | 0.561769 | 0.250 |
| R-HSA-9609507 | Protein localization | 0.561769 | 0.250 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.562337 | 0.250 |
| R-HSA-9830369 | Kidney development | 0.562337 | 0.250 |
| R-HSA-196807 | Nicotinate metabolism | 0.562337 | 0.250 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.562337 | 0.250 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.567144 | 0.246 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.576600 | 0.239 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.576600 | 0.239 |
| R-HSA-9711097 | Cellular response to starvation | 0.577423 | 0.239 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.581251 | 0.236 |
| R-HSA-189445 | Metabolism of porphyrins | 0.581251 | 0.236 |
| R-HSA-5688426 | Deubiquitination | 0.583842 | 0.234 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.585852 | 0.232 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.585852 | 0.232 |
| R-HSA-109581 | Apoptosis | 0.589652 | 0.229 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.590401 | 0.229 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.590401 | 0.229 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.590401 | 0.229 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.590401 | 0.229 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.591195 | 0.228 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.594902 | 0.226 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.594902 | 0.226 |
| R-HSA-380287 | Centrosome maturation | 0.599353 | 0.222 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.599353 | 0.222 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.603265 | 0.219 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.603755 | 0.219 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.608109 | 0.216 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.608109 | 0.216 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.612416 | 0.213 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.616676 | 0.210 |
| R-HSA-6806834 | Signaling by MET | 0.620889 | 0.207 |
| R-HSA-9833482 | PKR-mediated signaling | 0.620889 | 0.207 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.624759 | 0.204 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.625056 | 0.204 |
| R-HSA-611105 | Respiratory electron transport | 0.638690 | 0.195 |
| R-HSA-1500620 | Meiosis | 0.641274 | 0.193 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.644752 | 0.191 |
| R-HSA-9658195 | Leishmania infection | 0.644752 | 0.191 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.645218 | 0.190 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.645218 | 0.190 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.645218 | 0.190 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.649119 | 0.188 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.652977 | 0.185 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.656794 | 0.183 |
| R-HSA-69275 | G2/M Transition | 0.660136 | 0.180 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.664301 | 0.178 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.665336 | 0.177 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.667994 | 0.175 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.675258 | 0.171 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.675258 | 0.171 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.675258 | 0.171 |
| R-HSA-68877 | Mitotic Prometaphase | 0.678059 | 0.169 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.678830 | 0.168 |
| R-HSA-195721 | Signaling by WNT | 0.681059 | 0.167 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.685859 | 0.164 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.692734 | 0.159 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.692734 | 0.159 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.696115 | 0.157 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.696115 | 0.157 |
| R-HSA-74160 | Gene expression (Transcription) | 0.698944 | 0.156 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.699969 | 0.155 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.702767 | 0.153 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.706039 | 0.151 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.706039 | 0.151 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.709275 | 0.149 |
| R-HSA-5357801 | Programmed Cell Death | 0.709306 | 0.149 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.712475 | 0.147 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.712475 | 0.147 |
| R-HSA-1500931 | Cell-Cell communication | 0.716447 | 0.145 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.718771 | 0.143 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.718771 | 0.143 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.723888 | 0.140 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.733917 | 0.134 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.736848 | 0.133 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.748252 | 0.126 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.751026 | 0.124 |
| R-HSA-212436 | Generic Transcription Pathway | 0.754621 | 0.122 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.760489 | 0.119 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.764444 | 0.117 |
| R-HSA-68875 | Mitotic Prophase | 0.772147 | 0.112 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.774659 | 0.111 |
| R-HSA-3371556 | Cellular response to heat stress | 0.774659 | 0.111 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.774659 | 0.111 |
| R-HSA-8939211 | ESR-mediated signaling | 0.775578 | 0.110 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.782030 | 0.107 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.793786 | 0.100 |
| R-HSA-1474165 | Reproduction | 0.800534 | 0.097 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.804911 | 0.094 |
| R-HSA-163685 | Integration of energy metabolism | 0.815439 | 0.089 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.819491 | 0.086 |
| R-HSA-6807070 | PTEN Regulation | 0.821483 | 0.085 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.821483 | 0.085 |
| R-HSA-68886 | M Phase | 0.821941 | 0.085 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.826861 | 0.083 |
| R-HSA-2187338 | Visual phototransduction | 0.838458 | 0.077 |
| R-HSA-166520 | Signaling by NTRKs | 0.840243 | 0.076 |
| R-HSA-446728 | Cell junction organization | 0.841020 | 0.075 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.843752 | 0.074 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.845478 | 0.073 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.846385 | 0.072 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.847185 | 0.072 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.850543 | 0.070 |
| R-HSA-73887 | Death Receptor Signaling | 0.850543 | 0.070 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.856827 | 0.067 |
| R-HSA-877300 | Interferon gamma signaling | 0.858621 | 0.066 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.860183 | 0.065 |
| R-HSA-199991 | Membrane Trafficking | 0.862387 | 0.064 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.866264 | 0.062 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.866264 | 0.062 |
| R-HSA-162582 | Signal Transduction | 0.877312 | 0.057 |
| R-HSA-418555 | G alpha (s) signalling events | 0.877648 | 0.057 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.882973 | 0.054 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.896457 | 0.047 |
| R-HSA-983712 | Ion channel transport | 0.899859 | 0.046 |
| R-HSA-5617833 | Cilium Assembly | 0.900968 | 0.045 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.904812 | 0.043 |
| R-HSA-112316 | Neuronal System | 0.907024 | 0.042 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.907370 | 0.042 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.911408 | 0.040 |
| R-HSA-8953854 | Metabolism of RNA | 0.912938 | 0.040 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.914901 | 0.039 |
| R-HSA-6805567 | Keratinization | 0.918057 | 0.037 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.920757 | 0.036 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.923360 | 0.035 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.925030 | 0.034 |
| R-HSA-68882 | Mitotic Anaphase | 0.926704 | 0.033 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.927517 | 0.033 |
| R-HSA-418990 | Adherens junctions interactions | 0.928321 | 0.032 |
| R-HSA-9748784 | Drug ADME | 0.928321 | 0.032 |
| R-HSA-8951664 | Neddylation | 0.930681 | 0.031 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.937306 | 0.028 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.938124 | 0.028 |
| R-HSA-913531 | Interferon Signaling | 0.938124 | 0.028 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.943301 | 0.025 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.944091 | 0.025 |
| R-HSA-421270 | Cell-cell junction organization | 0.950417 | 0.022 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.952866 | 0.021 |
| R-HSA-9679506 | SARS-CoV Infections | 0.954037 | 0.020 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.956917 | 0.019 |
| R-HSA-416476 | G alpha (q) signalling events | 0.957127 | 0.019 |
| R-HSA-597592 | Post-translational protein modification | 0.963430 | 0.016 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.967596 | 0.014 |
| R-HSA-6798695 | Neutrophil degranulation | 0.969038 | 0.014 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.969703 | 0.013 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.970041 | 0.013 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.977872 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 0.978119 | 0.010 |
| R-HSA-109582 | Hemostasis | 0.978770 | 0.009 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.982126 | 0.008 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.983103 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.986046 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.990488 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.991432 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 0.993222 | 0.003 |
| R-HSA-72766 | Translation | 0.993374 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.993584 | 0.003 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.993940 | 0.003 |
| R-HSA-449147 | Signaling by Interleukins | 0.994019 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.995063 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.996941 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.997718 | 0.001 |
| R-HSA-1280218 | Adaptive Immune System | 0.997763 | 0.001 |
| R-HSA-1643685 | Disease | 0.998176 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998693 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999063 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999328 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999451 | 0.000 |
| R-HSA-9824446 | Viral Infection Pathways | 0.999780 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999903 | 0.000 |
| R-HSA-168256 | Immune System | 0.999907 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.849 | 0.574 | 1 | 0.876 |
CLK3 |
0.847 | 0.456 | 1 | 0.829 |
HIPK4 |
0.846 | 0.490 | 1 | 0.834 |
KIS |
0.844 | 0.523 | 1 | 0.897 |
DYRK2 |
0.844 | 0.554 | 1 | 0.892 |
CDK18 |
0.842 | 0.573 | 1 | 0.873 |
CDK19 |
0.842 | 0.551 | 1 | 0.874 |
CDK7 |
0.838 | 0.537 | 1 | 0.892 |
CDK8 |
0.837 | 0.529 | 1 | 0.883 |
HIPK1 |
0.837 | 0.527 | 1 | 0.898 |
DYRK4 |
0.835 | 0.540 | 1 | 0.885 |
JNK2 |
0.832 | 0.551 | 1 | 0.871 |
P38B |
0.832 | 0.564 | 1 | 0.884 |
SRPK1 |
0.832 | 0.289 | -3 | 0.671 |
ERK1 |
0.830 | 0.537 | 1 | 0.887 |
P38A |
0.829 | 0.547 | 1 | 0.901 |
CDK17 |
0.829 | 0.538 | 1 | 0.838 |
CDK13 |
0.829 | 0.507 | 1 | 0.886 |
P38G |
0.829 | 0.539 | 1 | 0.841 |
CDK3 |
0.829 | 0.490 | 1 | 0.853 |
CLK2 |
0.828 | 0.369 | -3 | 0.662 |
HIPK3 |
0.828 | 0.509 | 1 | 0.883 |
ERK5 |
0.828 | 0.366 | 1 | 0.834 |
P38D |
0.828 | 0.555 | 1 | 0.870 |
NLK |
0.827 | 0.462 | 1 | 0.855 |
CDK5 |
0.826 | 0.504 | 1 | 0.891 |
CDK1 |
0.826 | 0.501 | 1 | 0.867 |
CDK12 |
0.826 | 0.510 | 1 | 0.874 |
MAK |
0.825 | 0.467 | -2 | 0.823 |
DYRK1A |
0.824 | 0.438 | 1 | 0.888 |
PRKD1 |
0.824 | 0.231 | -3 | 0.760 |
CDKL5 |
0.824 | 0.219 | -3 | 0.700 |
DYRK1B |
0.824 | 0.497 | 1 | 0.876 |
JNK3 |
0.824 | 0.521 | 1 | 0.886 |
CLK1 |
0.823 | 0.348 | -3 | 0.636 |
CLK4 |
0.823 | 0.338 | -3 | 0.660 |
ICK |
0.822 | 0.335 | -3 | 0.744 |
CDK9 |
0.821 | 0.491 | 1 | 0.891 |
CDK16 |
0.820 | 0.510 | 1 | 0.850 |
CDK14 |
0.819 | 0.510 | 1 | 0.878 |
DYRK3 |
0.818 | 0.420 | 1 | 0.881 |
CDK10 |
0.817 | 0.476 | 1 | 0.877 |
COT |
0.817 | 0.020 | 2 | 0.795 |
CDKL1 |
0.817 | 0.162 | -3 | 0.700 |
NDR2 |
0.816 | 0.130 | -3 | 0.778 |
AURC |
0.814 | 0.204 | -2 | 0.717 |
PIM3 |
0.814 | 0.093 | -3 | 0.757 |
MTOR |
0.813 | 0.129 | 1 | 0.716 |
SRPK2 |
0.813 | 0.206 | -3 | 0.592 |
MOS |
0.813 | 0.108 | 1 | 0.694 |
PRKD2 |
0.813 | 0.147 | -3 | 0.694 |
CDC7 |
0.811 | 0.014 | 1 | 0.647 |
SKMLCK |
0.811 | 0.146 | -2 | 0.863 |
RSK2 |
0.810 | 0.107 | -3 | 0.684 |
ERK2 |
0.809 | 0.468 | 1 | 0.888 |
PRPK |
0.808 | -0.023 | -1 | 0.832 |
SRPK3 |
0.806 | 0.170 | -3 | 0.628 |
P90RSK |
0.806 | 0.085 | -3 | 0.691 |
RSK3 |
0.805 | 0.091 | -3 | 0.674 |
WNK1 |
0.805 | 0.046 | -2 | 0.850 |
CAMK1B |
0.804 | 0.030 | -3 | 0.727 |
ATR |
0.804 | 0.037 | 1 | 0.675 |
PRP4 |
0.804 | 0.345 | -3 | 0.707 |
MAPKAPK3 |
0.804 | 0.071 | -3 | 0.695 |
MOK |
0.804 | 0.381 | 1 | 0.876 |
JNK1 |
0.804 | 0.452 | 1 | 0.858 |
PIM1 |
0.804 | 0.089 | -3 | 0.689 |
NDR1 |
0.803 | 0.049 | -3 | 0.742 |
CAMLCK |
0.803 | 0.116 | -2 | 0.828 |
NUAK2 |
0.803 | 0.040 | -3 | 0.732 |
MAPKAPK2 |
0.802 | 0.071 | -3 | 0.662 |
PKN3 |
0.802 | 0.037 | -3 | 0.722 |
CDK2 |
0.802 | 0.344 | 1 | 0.855 |
CHAK2 |
0.800 | 0.048 | -1 | 0.799 |
PKACB |
0.799 | 0.151 | -2 | 0.706 |
DAPK2 |
0.799 | 0.088 | -3 | 0.745 |
CAMK2D |
0.799 | 0.027 | -3 | 0.726 |
CDK6 |
0.799 | 0.457 | 1 | 0.880 |
PKACG |
0.799 | 0.083 | -2 | 0.733 |
LATS2 |
0.799 | 0.043 | -5 | 0.745 |
MST4 |
0.798 | 0.008 | 2 | 0.799 |
CDK4 |
0.798 | 0.468 | 1 | 0.868 |
PDHK4 |
0.797 | -0.169 | 1 | 0.683 |
GCN2 |
0.797 | -0.124 | 2 | 0.730 |
TBK1 |
0.797 | -0.091 | 1 | 0.547 |
NIK |
0.797 | 0.012 | -3 | 0.746 |
BMPR2 |
0.797 | -0.112 | -2 | 0.780 |
MNK2 |
0.797 | 0.116 | -2 | 0.796 |
PKCD |
0.797 | 0.061 | 2 | 0.711 |
NEK6 |
0.796 | 0.007 | -2 | 0.740 |
PKG2 |
0.796 | 0.135 | -2 | 0.699 |
ERK7 |
0.795 | 0.225 | 2 | 0.549 |
IKKB |
0.795 | -0.123 | -2 | 0.638 |
PRKD3 |
0.795 | 0.075 | -3 | 0.647 |
LATS1 |
0.795 | 0.135 | -3 | 0.803 |
PAK6 |
0.795 | 0.168 | -2 | 0.731 |
GRK1 |
0.795 | 0.054 | -2 | 0.704 |
PKN2 |
0.795 | 0.006 | -3 | 0.718 |
RAF1 |
0.795 | -0.171 | 1 | 0.631 |
MPSK1 |
0.795 | 0.257 | 1 | 0.686 |
RIPK3 |
0.794 | -0.075 | 3 | 0.655 |
P70S6KB |
0.794 | 0.045 | -3 | 0.681 |
MLK2 |
0.794 | 0.046 | 2 | 0.749 |
AMPKA1 |
0.794 | -0.003 | -3 | 0.749 |
PAK1 |
0.794 | 0.090 | -2 | 0.809 |
RSK4 |
0.794 | 0.096 | -3 | 0.679 |
IKKE |
0.793 | -0.106 | 1 | 0.536 |
TSSK1 |
0.793 | 0.046 | -3 | 0.775 |
MARK4 |
0.793 | -0.019 | 4 | 0.812 |
AKT2 |
0.792 | 0.104 | -3 | 0.599 |
AURB |
0.792 | 0.128 | -2 | 0.706 |
DSTYK |
0.792 | -0.132 | 2 | 0.826 |
PAK3 |
0.792 | 0.076 | -2 | 0.792 |
CAMK2G |
0.792 | -0.104 | 2 | 0.734 |
TGFBR2 |
0.792 | -0.058 | -2 | 0.693 |
CAMK2A |
0.791 | 0.047 | 2 | 0.735 |
SGK3 |
0.791 | 0.101 | -3 | 0.679 |
AMPKA2 |
0.791 | 0.011 | -3 | 0.724 |
HUNK |
0.791 | -0.087 | 2 | 0.735 |
ULK2 |
0.791 | -0.161 | 2 | 0.693 |
PRKX |
0.790 | 0.123 | -3 | 0.622 |
PDHK1 |
0.790 | -0.175 | 1 | 0.657 |
MSK1 |
0.790 | 0.091 | -3 | 0.662 |
MSK2 |
0.790 | 0.047 | -3 | 0.660 |
PKCA |
0.790 | 0.075 | 2 | 0.664 |
TSSK2 |
0.790 | 0.012 | -5 | 0.843 |
MNK1 |
0.789 | 0.088 | -2 | 0.792 |
GRK5 |
0.788 | -0.134 | -3 | 0.718 |
PKCB |
0.788 | 0.039 | 2 | 0.679 |
MLK1 |
0.788 | -0.119 | 2 | 0.746 |
IKKA |
0.786 | -0.043 | -2 | 0.627 |
CAMK2B |
0.786 | 0.003 | 2 | 0.717 |
NEK7 |
0.786 | -0.152 | -3 | 0.739 |
PHKG1 |
0.786 | -0.001 | -3 | 0.721 |
BMPR1B |
0.785 | 0.011 | 1 | 0.592 |
MASTL |
0.785 | -0.149 | -2 | 0.715 |
PKCG |
0.785 | 0.026 | 2 | 0.668 |
PKACA |
0.785 | 0.120 | -2 | 0.675 |
NEK9 |
0.784 | -0.103 | 2 | 0.771 |
BUB1 |
0.784 | 0.276 | -5 | 0.797 |
PIM2 |
0.784 | 0.073 | -3 | 0.643 |
PKCZ |
0.784 | 0.033 | 2 | 0.713 |
MLK3 |
0.784 | -0.012 | 2 | 0.681 |
IRE1 |
0.784 | -0.063 | 1 | 0.624 |
GSK3A |
0.783 | 0.168 | 4 | 0.483 |
MELK |
0.783 | -0.026 | -3 | 0.699 |
MYLK4 |
0.783 | 0.048 | -2 | 0.787 |
VRK2 |
0.783 | 0.063 | 1 | 0.731 |
DNAPK |
0.782 | 0.019 | 1 | 0.570 |
AURA |
0.782 | 0.105 | -2 | 0.697 |
NIM1 |
0.782 | -0.062 | 3 | 0.677 |
RIPK1 |
0.782 | -0.159 | 1 | 0.632 |
NUAK1 |
0.782 | -0.039 | -3 | 0.680 |
QSK |
0.782 | -0.006 | 4 | 0.786 |
GRK7 |
0.782 | 0.012 | 1 | 0.609 |
TGFBR1 |
0.781 | -0.014 | -2 | 0.714 |
WNK3 |
0.781 | -0.207 | 1 | 0.623 |
PKR |
0.781 | -0.011 | 1 | 0.654 |
CAMK4 |
0.781 | -0.062 | -3 | 0.693 |
SMG1 |
0.781 | -0.015 | 1 | 0.640 |
NEK2 |
0.780 | -0.022 | 2 | 0.752 |
ATM |
0.780 | -0.061 | 1 | 0.617 |
PAK2 |
0.780 | 0.035 | -2 | 0.784 |
ALK4 |
0.779 | -0.048 | -2 | 0.739 |
AKT1 |
0.779 | 0.089 | -3 | 0.624 |
BCKDK |
0.779 | -0.172 | -1 | 0.729 |
FAM20C |
0.778 | -0.002 | 2 | 0.574 |
DLK |
0.778 | -0.190 | 1 | 0.633 |
CHK1 |
0.778 | 0.011 | -3 | 0.734 |
ULK1 |
0.777 | -0.200 | -3 | 0.686 |
DCAMKL1 |
0.777 | 0.007 | -3 | 0.698 |
MAPKAPK5 |
0.777 | -0.041 | -3 | 0.619 |
GRK6 |
0.777 | -0.154 | 1 | 0.619 |
PKCH |
0.777 | -0.010 | 2 | 0.651 |
ANKRD3 |
0.776 | -0.180 | 1 | 0.665 |
PAK4 |
0.775 | 0.132 | -2 | 0.702 |
AKT3 |
0.775 | 0.108 | -3 | 0.566 |
YSK4 |
0.775 | -0.100 | 1 | 0.584 |
IRE2 |
0.775 | -0.082 | 2 | 0.661 |
TTBK2 |
0.775 | -0.185 | 2 | 0.638 |
QIK |
0.774 | -0.106 | -3 | 0.710 |
SIK |
0.773 | -0.044 | -3 | 0.649 |
PAK5 |
0.773 | 0.104 | -2 | 0.681 |
GRK4 |
0.773 | -0.173 | -2 | 0.725 |
PASK |
0.773 | 0.049 | -3 | 0.780 |
GSK3B |
0.773 | 0.064 | 4 | 0.477 |
TLK2 |
0.772 | -0.056 | 1 | 0.589 |
MST3 |
0.772 | 0.005 | 2 | 0.786 |
SSTK |
0.771 | 0.023 | 4 | 0.775 |
MEK1 |
0.771 | -0.179 | 2 | 0.757 |
CHAK1 |
0.771 | -0.120 | 2 | 0.693 |
WNK4 |
0.771 | -0.059 | -2 | 0.829 |
ALK2 |
0.771 | -0.057 | -2 | 0.712 |
PKCT |
0.771 | 0.009 | 2 | 0.656 |
SMMLCK |
0.770 | 0.023 | -3 | 0.691 |
CK1E |
0.770 | -0.037 | -3 | 0.460 |
NEK5 |
0.769 | -0.031 | 1 | 0.648 |
SGK1 |
0.769 | 0.088 | -3 | 0.543 |
BRSK1 |
0.769 | -0.069 | -3 | 0.690 |
MARK3 |
0.769 | -0.047 | 4 | 0.737 |
PKCI |
0.768 | 0.024 | 2 | 0.687 |
ACVR2A |
0.768 | -0.095 | -2 | 0.677 |
MLK4 |
0.768 | -0.117 | 2 | 0.658 |
PINK1 |
0.768 | -0.009 | 1 | 0.760 |
ACVR2B |
0.768 | -0.089 | -2 | 0.683 |
PKCE |
0.768 | 0.050 | 2 | 0.660 |
CAMK1G |
0.768 | -0.052 | -3 | 0.636 |
SBK |
0.768 | 0.103 | -3 | 0.495 |
P70S6K |
0.767 | 0.005 | -3 | 0.601 |
BRSK2 |
0.767 | -0.100 | -3 | 0.699 |
LKB1 |
0.767 | 0.056 | -3 | 0.737 |
DAPK3 |
0.766 | 0.061 | -3 | 0.695 |
PERK |
0.766 | -0.123 | -2 | 0.715 |
IRAK4 |
0.765 | -0.090 | 1 | 0.629 |
MEK5 |
0.765 | -0.183 | 2 | 0.737 |
MARK2 |
0.765 | -0.074 | 4 | 0.710 |
MEKK1 |
0.764 | -0.130 | 1 | 0.623 |
DCAMKL2 |
0.764 | -0.051 | -3 | 0.697 |
GAK |
0.763 | 0.023 | 1 | 0.713 |
PLK1 |
0.763 | -0.197 | -2 | 0.657 |
ROCK2 |
0.763 | 0.095 | -3 | 0.697 |
TAO3 |
0.763 | -0.039 | 1 | 0.625 |
CAMK1D |
0.763 | -0.012 | -3 | 0.594 |
MEKK2 |
0.762 | -0.136 | 2 | 0.727 |
DRAK1 |
0.762 | -0.132 | 1 | 0.566 |
PKN1 |
0.762 | 0.010 | -3 | 0.617 |
CK1D |
0.762 | -0.031 | -3 | 0.414 |
PLK4 |
0.762 | -0.110 | 2 | 0.514 |
PBK |
0.761 | 0.098 | 1 | 0.666 |
PDK1 |
0.761 | -0.016 | 1 | 0.644 |
HRI |
0.761 | -0.190 | -2 | 0.736 |
GRK2 |
0.761 | -0.121 | -2 | 0.639 |
SNRK |
0.760 | -0.177 | 2 | 0.559 |
BMPR1A |
0.760 | -0.056 | 1 | 0.568 |
PHKG2 |
0.760 | -0.074 | -3 | 0.663 |
DAPK1 |
0.760 | 0.047 | -3 | 0.673 |
MRCKB |
0.759 | 0.066 | -3 | 0.627 |
CK1A2 |
0.759 | -0.041 | -3 | 0.412 |
MEKK6 |
0.759 | -0.021 | 1 | 0.620 |
ZAK |
0.759 | -0.169 | 1 | 0.590 |
TLK1 |
0.759 | -0.146 | -2 | 0.727 |
BRAF |
0.758 | -0.170 | -4 | 0.828 |
MAP3K15 |
0.758 | -0.005 | 1 | 0.596 |
TNIK |
0.758 | 0.032 | 3 | 0.800 |
DMPK1 |
0.757 | 0.102 | -3 | 0.647 |
CAMKK2 |
0.757 | -0.044 | -2 | 0.658 |
CK1G1 |
0.757 | -0.079 | -3 | 0.455 |
MARK1 |
0.757 | -0.117 | 4 | 0.755 |
HGK |
0.756 | -0.022 | 3 | 0.791 |
CAMK1A |
0.756 | 0.011 | -3 | 0.563 |
PLK3 |
0.756 | -0.190 | 2 | 0.673 |
GCK |
0.755 | -0.033 | 1 | 0.592 |
CHK2 |
0.755 | -0.006 | -3 | 0.545 |
MEKK3 |
0.755 | -0.255 | 1 | 0.618 |
NEK4 |
0.755 | -0.089 | 1 | 0.601 |
TAO2 |
0.755 | -0.091 | 2 | 0.770 |
NEK11 |
0.754 | -0.152 | 1 | 0.606 |
NEK1 |
0.754 | -0.024 | 1 | 0.619 |
KHS1 |
0.754 | 0.023 | 1 | 0.586 |
PKG1 |
0.754 | 0.058 | -2 | 0.637 |
HPK1 |
0.753 | -0.038 | 1 | 0.584 |
EEF2K |
0.753 | -0.055 | 3 | 0.738 |
HASPIN |
0.753 | 0.064 | -1 | 0.714 |
CRIK |
0.753 | 0.081 | -3 | 0.636 |
MRCKA |
0.752 | 0.034 | -3 | 0.645 |
LRRK2 |
0.752 | -0.051 | 2 | 0.766 |
MINK |
0.752 | -0.069 | 1 | 0.590 |
CAMKK1 |
0.752 | -0.148 | -2 | 0.640 |
LOK |
0.751 | -0.021 | -2 | 0.684 |
PDHK3_TYR |
0.750 | 0.295 | 4 | 0.879 |
NEK8 |
0.750 | -0.179 | 2 | 0.735 |
KHS2 |
0.750 | 0.009 | 1 | 0.591 |
GRK3 |
0.749 | -0.113 | -2 | 0.603 |
VRK1 |
0.748 | -0.098 | 2 | 0.757 |
MST2 |
0.746 | -0.143 | 1 | 0.603 |
TTBK1 |
0.746 | -0.208 | 2 | 0.544 |
ROCK1 |
0.745 | 0.058 | -3 | 0.644 |
CK2A2 |
0.745 | -0.066 | 1 | 0.511 |
TAK1 |
0.745 | -0.155 | 1 | 0.607 |
LIMK2_TYR |
0.745 | 0.232 | -3 | 0.777 |
YSK1 |
0.744 | -0.063 | 2 | 0.752 |
BIKE |
0.744 | 0.068 | 1 | 0.653 |
SLK |
0.743 | -0.067 | -2 | 0.623 |
IRAK1 |
0.743 | -0.280 | -1 | 0.711 |
PKMYT1_TYR |
0.742 | 0.174 | 3 | 0.778 |
AAK1 |
0.742 | 0.132 | 1 | 0.601 |
NEK3 |
0.741 | -0.078 | 1 | 0.609 |
TESK1_TYR |
0.740 | 0.106 | 3 | 0.797 |
MAP2K4_TYR |
0.737 | 0.057 | -1 | 0.839 |
MST1 |
0.736 | -0.165 | 1 | 0.585 |
PDHK4_TYR |
0.736 | 0.078 | 2 | 0.780 |
MYO3B |
0.736 | -0.008 | 2 | 0.759 |
CK2A1 |
0.736 | -0.072 | 1 | 0.489 |
OSR1 |
0.734 | -0.058 | 2 | 0.727 |
MEK2 |
0.734 | -0.219 | 2 | 0.727 |
STK33 |
0.734 | -0.161 | 2 | 0.513 |
ASK1 |
0.733 | -0.069 | 1 | 0.588 |
MAP2K6_TYR |
0.732 | -0.013 | -1 | 0.843 |
PLK2 |
0.732 | -0.143 | -3 | 0.625 |
MAP2K7_TYR |
0.731 | -0.095 | 2 | 0.762 |
RIPK2 |
0.729 | -0.281 | 1 | 0.562 |
BMPR2_TYR |
0.729 | -0.021 | -1 | 0.842 |
EPHA6 |
0.728 | 0.027 | -1 | 0.807 |
PDHK1_TYR |
0.728 | -0.062 | -1 | 0.847 |
ABL2 |
0.727 | 0.064 | -1 | 0.758 |
TTK |
0.727 | -0.141 | -2 | 0.703 |
TAO1 |
0.727 | -0.088 | 1 | 0.562 |
LIMK1_TYR |
0.726 | -0.029 | 2 | 0.762 |
PINK1_TYR |
0.725 | -0.159 | 1 | 0.686 |
TNK2 |
0.725 | 0.040 | 3 | 0.695 |
RET |
0.725 | -0.062 | 1 | 0.640 |
MST1R |
0.725 | -0.052 | 3 | 0.757 |
YANK3 |
0.725 | -0.085 | 2 | 0.329 |
EPHB4 |
0.724 | 0.001 | -1 | 0.779 |
ABL1 |
0.724 | 0.049 | -1 | 0.747 |
JAK2 |
0.723 | -0.029 | 1 | 0.639 |
MYO3A |
0.723 | -0.104 | 1 | 0.585 |
CSF1R |
0.721 | -0.052 | 3 | 0.740 |
ROS1 |
0.721 | -0.084 | 3 | 0.698 |
TYRO3 |
0.720 | -0.098 | 3 | 0.733 |
CK1A |
0.720 | -0.079 | -3 | 0.338 |
TNK1 |
0.719 | 0.019 | 3 | 0.724 |
TNNI3K_TYR |
0.719 | 0.032 | 1 | 0.657 |
LCK |
0.719 | -0.006 | -1 | 0.809 |
TXK |
0.718 | -0.010 | 1 | 0.623 |
FGR |
0.718 | -0.082 | 1 | 0.669 |
TYK2 |
0.718 | -0.170 | 1 | 0.630 |
DDR1 |
0.717 | -0.117 | 4 | 0.782 |
JAK1 |
0.716 | -0.020 | 1 | 0.580 |
BLK |
0.715 | -0.013 | -1 | 0.810 |
ALPHAK3 |
0.715 | -0.155 | -1 | 0.732 |
YES1 |
0.715 | -0.087 | -1 | 0.812 |
HCK |
0.715 | -0.073 | -1 | 0.802 |
JAK3 |
0.715 | -0.112 | 1 | 0.631 |
EPHA4 |
0.713 | -0.059 | 2 | 0.678 |
NEK10_TYR |
0.712 | -0.073 | 1 | 0.561 |
EPHB3 |
0.710 | -0.069 | -1 | 0.758 |
ITK |
0.710 | -0.083 | -1 | 0.762 |
KDR |
0.709 | -0.100 | 3 | 0.698 |
SRMS |
0.708 | -0.129 | 1 | 0.634 |
MERTK |
0.708 | -0.072 | 3 | 0.711 |
FER |
0.708 | -0.177 | 1 | 0.667 |
EPHB1 |
0.708 | -0.114 | 1 | 0.634 |
KIT |
0.708 | -0.131 | 3 | 0.736 |
MET |
0.708 | -0.079 | 3 | 0.737 |
INSRR |
0.707 | -0.178 | 3 | 0.665 |
FGFR2 |
0.707 | -0.138 | 3 | 0.708 |
FYN |
0.707 | -0.041 | -1 | 0.803 |
EPHB2 |
0.707 | -0.091 | -1 | 0.755 |
STLK3 |
0.706 | -0.214 | 1 | 0.561 |
AXL |
0.705 | -0.122 | 3 | 0.700 |
BMX |
0.705 | -0.083 | -1 | 0.702 |
TEK |
0.704 | -0.123 | 3 | 0.661 |
FGFR1 |
0.704 | -0.132 | 3 | 0.686 |
DDR2 |
0.704 | -0.033 | 3 | 0.652 |
PDGFRB |
0.703 | -0.209 | 3 | 0.737 |
EPHA1 |
0.702 | -0.082 | 3 | 0.720 |
EPHA7 |
0.701 | -0.087 | 2 | 0.671 |
FLT3 |
0.701 | -0.214 | 3 | 0.737 |
PTK2B |
0.701 | -0.048 | -1 | 0.731 |
WEE1_TYR |
0.700 | -0.114 | -1 | 0.711 |
LYN |
0.699 | -0.104 | 3 | 0.656 |
TEC |
0.699 | -0.141 | -1 | 0.695 |
PDGFRA |
0.699 | -0.209 | 3 | 0.739 |
ALK |
0.698 | -0.163 | 3 | 0.656 |
LTK |
0.698 | -0.151 | 3 | 0.683 |
EPHA3 |
0.698 | -0.127 | 2 | 0.642 |
FRK |
0.697 | -0.129 | -1 | 0.797 |
BTK |
0.696 | -0.215 | -1 | 0.721 |
FGFR3 |
0.695 | -0.164 | 3 | 0.683 |
FLT1 |
0.695 | -0.168 | -1 | 0.771 |
SRC |
0.693 | -0.114 | -1 | 0.784 |
NTRK3 |
0.693 | -0.143 | -1 | 0.715 |
NTRK1 |
0.692 | -0.245 | -1 | 0.756 |
PTK6 |
0.691 | -0.228 | -1 | 0.681 |
INSR |
0.691 | -0.206 | 3 | 0.650 |
EPHA8 |
0.691 | -0.110 | -1 | 0.754 |
CK1G3 |
0.690 | -0.112 | -3 | 0.300 |
EPHA5 |
0.690 | -0.125 | 2 | 0.652 |
ERBB2 |
0.689 | -0.224 | 1 | 0.578 |
MATK |
0.689 | -0.138 | -1 | 0.678 |
PTK2 |
0.689 | -0.050 | -1 | 0.758 |
CSK |
0.689 | -0.152 | 2 | 0.674 |
FLT4 |
0.688 | -0.231 | 3 | 0.675 |
NTRK2 |
0.687 | -0.261 | 3 | 0.676 |
YANK2 |
0.685 | -0.127 | 2 | 0.345 |
EGFR |
0.685 | -0.143 | 1 | 0.508 |
SYK |
0.684 | -0.074 | -1 | 0.745 |
FGFR4 |
0.683 | -0.148 | -1 | 0.709 |
EPHA2 |
0.682 | -0.104 | -1 | 0.718 |
MUSK |
0.679 | -0.147 | 1 | 0.508 |
ERBB4 |
0.678 | -0.110 | 1 | 0.511 |
ZAP70 |
0.677 | -0.029 | -1 | 0.684 |
CK1G2 |
0.675 | -0.110 | -3 | 0.379 |
IGF1R |
0.673 | -0.208 | 3 | 0.590 |
FES |
0.663 | -0.184 | -1 | 0.666 |