Motif 304 (n=144)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | Y536 | ochoa | Golgin A8 family member Q | None |
| A6NF01 | POM121B | S281 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NFI3 | ZNF316 | S112 | ochoa | Zinc finger protein 316 | May be involved in transcriptional regulation. {ECO:0000250}. |
| A6NGB9 | WIPF3 | S383 | ochoa | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity). {ECO:0000250}. |
| A6NI28 | ARHGAP42 | S811 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NJG2 | SOWAHD | S22 | ochoa | Ankyrin repeat domain-containing protein SOWAHD (Ankyrin repeat domain-containing protein 58) (Protein sosondowah homolog D) | None |
| A6NMD2 | GOLGA8J | Y536 | ochoa | Golgin subfamily A member 8J | None |
| A8CG34 | POM121C | S674 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| A8CG34 | POM121C | S971 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| D6RIA3 | C4orf54 | S1707 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| H3BQL2 | GOLGA8T | Y535 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | Y536 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | Y535 | ochoa | Golgin subfamily A member 8R | None |
| O14519 | CDK2AP1 | S24 | ochoa | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O14737 | PDCD5 | S42 | ochoa | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O15156 | ZBTB7B | S487 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15417 | TNRC18 | S1857 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O75152 | ZC3H11A | S687 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75179 | ANKRD17 | S19 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75376 | NCOR1 | S1592 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75427 | LRCH4 | S457 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75626 | PRDM1 | S511 | ochoa | PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}. |
| O75962 | TRIO | S2440 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O95071 | UBR5 | S1772 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95359 | TACC2 | S1025 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S1562 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95817 | BAG3 | S136 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O96005 | CLPTM1 | S22 | ochoa | Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}. |
| P03372 | ESR1 | S294 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04921 | GYPC | S104 | ochoa | Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) | This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. |
| P06401 | PGR | S345 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P09661 | SNRPA1 | S197 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P0C7U0 | ELFN1 | S674 | ochoa | Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28) | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| P0CJ92 | GOLGA8H | Y536 | ochoa | Golgin subfamily A member 8H | None |
| P10412 | H1-4 | S55 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10415 | BCL2 | S87 | ochoa|psp | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| P10746 | UROS | S240 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P16402 | H1-3 | S56 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S55 | ochoa|psp | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P18825 | ADRA2C | S338 | ochoa | Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. |
| P22413 | ENPP1 | S34 | ochoa | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] | Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:25344812, PubMed:27467858, PubMed:28011303, PubMed:35147247, PubMed:8001561). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). {ECO:0000250|UniProtKB:P06802, ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:25344812, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:28011303, ECO:0000269|PubMed:28964717, ECO:0000269|PubMed:35147247, ECO:0000269|PubMed:8001561, ECO:0000305|PubMed:11004006}. |
| P24928 | POLR2A | S1532 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P25440 | BRD2 | S608 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P29966 | MARCKS | S46 | ochoa|psp | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P29966 | MARCKS | S81 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P35221 | CTNNA1 | S117 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P40926 | MDH2 | S47 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P46379 | BAG6 | S1081 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P47974 | ZFP36L2 | S73 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48444 | ARCN1 | S195 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49006 | MARCKSL1 | S151 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P52824 | DGKQ | S376 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P52952 | NKX2-5 | S78 | ochoa | Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) | Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (PubMed:29899023). {ECO:0000250|UniProtKB:P42582, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:22849347, ECO:0000269|PubMed:26926761, ECO:0000269|PubMed:29899023}. |
| P55196 | AFDN | S1772 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55317 | FOXA1 | S338 | ochoa | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}. |
| P78413 | IRX4 | S473 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
| P80723 | BASP1 | S132 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P80723 | BASP1 | S194 | ochoa | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | None |
| P85037 | FOXK1 | S101 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01581 | HMGCS1 | S495 | ochoa | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q12834 | CDC20 | S41 | ochoa|psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q12962 | TAF10 | S44 | ochoa | Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:12601814, PubMed:18206972, PubMed:9885574). May regulate cyclin E expression (By similarity). {ECO:0000250|UniProtKB:Q8K0H5, ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:12601814, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9885574}. |
| Q13428 | TCOF1 | S823 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14258 | TRIM25 | S428 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14677 | CLINT1 | S299 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14761 | PTPRCAP | S178 | ochoa | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q15149 | PLEC | S476 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15274 | QPRT | S42 | ochoa | Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase) | Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}. |
| Q15464 | SHB | S211 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15528 | MED22 | S173 | ochoa | Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q5JPB2 | ZNF831 | S918 | ochoa | Zinc finger protein 831 | None |
| Q5JSZ5 | PRRC2B | S1507 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | S847 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SV97 | PERM1 | S213 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5SYE7 | NHSL1 | S1276 | ochoa | NHS-like protein 1 | None |
| Q5VTT5 | MYOM3 | S684 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q63ZY3 | KANK2 | S356 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6DKI7 | PVRIG | Y233 | psp | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}. |
| Q6IBW4 | NCAPH2 | S376 | psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6NZI2 | CAVIN1 | S36 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6PCD5 | RFWD3 | S46 | psp | E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) | E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276, ECO:0000269|PubMed:26474068, ECO:0000269|PubMed:28575657, ECO:0000269|PubMed:28575658, ECO:0000269|PubMed:28691929, ECO:0000269|PubMed:33321094}. |
| Q6SPF0 | SAMD1 | S161 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q6WKZ4 | RAB11FIP1 | S754 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZNB6 | NFXL1 | S65 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZUM4 | ARHGAP27 | S84 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q6ZVF9 | GPRIN3 | S32 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7L2J0 | MEPCE | S60 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z6I8 | C5orf24 | S121 | ochoa | UPF0461 protein C5orf24 | None |
| Q8IU68 | TMC8 | S703 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q8IWB9 | TEX2 | S91 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IY92 | SLX4 | S601 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N0Y2 | ZNF444 | S161 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N3D4 | EHBP1L1 | S285 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3D4 | EHBP1L1 | S1017 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3K9 | CMYA5 | S1157 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N4B5 | PRR18 | S101 | ochoa | Proline-rich protein 18 | None |
| Q8N4C8 | MINK1 | S699 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N5H7 | SH2D3C | S433 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NC51 | SERBP1 | S63 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NHL6 | LILRB1 | S522 | ochoa | Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}. |
| Q8TDN4 | CABLES1 | S109 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TE49 | OTUD7A | S744 | ochoa | OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2) | Deubiquitinase, which cleaves 'Lys-11'-linked polyubiquitin chains. Might be required for PA28-20S proteasome assembly (Probable). {ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:23827681, ECO:0000305|PubMed:31997314}. |
| Q92610 | ZNF592 | S678 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92837 | FRAT1 | S88 | ochoa | Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1) | Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:12556519}. |
| Q92908 | GATA6 | S266 | psp | Transcription factor GATA-6 (GATA-binding factor 6) | Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:33082341, ECO:0000269|PubMed:9315713}. |
| Q96C12 | ARMC5 | S85 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96C12 | ARMC5 | S102 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96G74 | OTUD5 | S64 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96HA1 | POM121 | S697 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96RY5 | CRAMP1 | S616 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99623 | PHB2 | S243 | psp | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BZS1 | FOXP3 | S270 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9BZS1 | FOXP3 | S274 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9GZV5 | WWTR1 | S117 | ochoa|psp | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H0Z9 | RBM38 | S195 | psp | RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) | RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}.; FUNCTION: (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication. {ECO:0000269|PubMed:29437973}. |
| Q9H6K5 | PRR36 | S165 | ochoa | Proline-rich protein 36 | None |
| Q9H6Z4 | RANBP3 | S211 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H7Z6 | KAT8 | S37 | ochoa | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9NPB0 | SAYSD1 | S25 | ochoa | SAYSvFN domain-containing protein 1 | Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (PubMed:36848233). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (PubMed:36848233). {ECO:0000269|PubMed:36848233}. |
| Q9NRR6 | INPP5E | S38 | ochoa | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}. |
| Q9NX00 | TMEM160 | S48 | ochoa | Transmembrane protein 160 | None |
| Q9NZ56 | FMN2 | S319 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9P227 | ARHGAP23 | S1349 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2A4 | ABI3 | S213 | psp | ABI gene family member 3 (New molecule including SH3) (Nesh) | May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}. |
| Q9UKK3 | PARP4 | S1335 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKY4 | POMT2 | S41 | ochoa | Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). {ECO:0000269|PubMed:14699049, ECO:0000269|PubMed:28512129}. |
| Q9UL51 | HCN2 | S146 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULI4 | KIF26A | S1262 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9UMS6 | SYNPO2 | S226 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNF1 | MAGED2 | S265 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9UQ35 | SRRM2 | S2272 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB3 | CTNND2 | S490 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y261 | FOXA2 | S107 | psp | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2I1 | NISCH | S1038 | ochoa | Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) | Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Also inhibits LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. {ECO:0000250, ECO:0000269|PubMed:10882231, ECO:0000269|PubMed:12868002, ECO:0000269|PubMed:15028619, ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:15475348}. |
| Q9Y446 | PKP3 | S260 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4F5 | CEP170B | S1548 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| P07737 | PFN1 | S28 | Sugiyama | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| Q13164 | MAPK7 | S562 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q9BZI1 | IRX2 | S46 | SIGNOR | Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) | None |
| Q9H6Z4 | RANBP3 | S57 | SIGNOR | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| O60610 | DIAPH1 | T1230 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| Q15751 | HERC1 | S3238 | Sugiyama | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| O95817 | BAG3 | S165 | Sugiyama | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| Q14694 | USP10 | S253 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.000164 | 3.786 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.000172 | 3.764 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.000129 | 3.889 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.000065 | 4.186 |
| R-HSA-8939211 | ESR-mediated signaling | 0.000293 | 3.534 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.000326 | 3.486 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.000709 | 3.149 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.000623 | 3.206 |
| R-HSA-6804754 | Regulation of TP53 Expression | 0.000774 | 3.111 |
| R-HSA-9733709 | Cardiogenesis | 0.000686 | 3.164 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.000709 | 3.149 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.001069 | 2.971 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.001350 | 2.870 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.001360 | 2.867 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.001758 | 2.755 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.002339 | 2.631 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.002325 | 2.634 |
| R-HSA-5688426 | Deubiquitination | 0.001932 | 2.714 |
| R-HSA-75153 | Apoptotic execution phase | 0.002245 | 2.649 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.003793 | 2.421 |
| R-HSA-1266738 | Developmental Biology | 0.003726 | 2.429 |
| R-HSA-2559583 | Cellular Senescence | 0.004122 | 2.385 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.005592 | 2.252 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.005635 | 2.249 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.005608 | 2.251 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.007470 | 2.127 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.008865 | 2.052 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.009637 | 2.016 |
| R-HSA-109581 | Apoptosis | 0.009906 | 2.004 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.011311 | 1.947 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.012845 | 1.891 |
| R-HSA-8949664 | Processing of SMDT1 | 0.012845 | 1.891 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.012845 | 1.891 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.014307 | 1.844 |
| R-HSA-5578768 | Physiological factors | 0.014307 | 1.844 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.015838 | 1.800 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.019099 | 1.719 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.020826 | 1.681 |
| R-HSA-9831926 | Nephron development | 0.022615 | 1.646 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 0.029552 | 1.529 |
| R-HSA-198765 | Signalling to ERK5 | 0.039208 | 1.407 |
| R-HSA-5083633 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 0.039208 | 1.407 |
| R-HSA-5083629 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 0.039208 | 1.407 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.048769 | 1.312 |
| R-HSA-1296061 | HCN channels | 0.058235 | 1.235 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.076888 | 1.114 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.076888 | 1.114 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.076888 | 1.114 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.095174 | 1.021 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.104181 | 0.982 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.130672 | 0.884 |
| R-HSA-202670 | ERKs are inactivated | 0.139328 | 0.856 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.050963 | 1.293 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.053491 | 1.272 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.053491 | 1.272 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.058676 | 1.232 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.058676 | 1.232 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.061331 | 1.212 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.066762 | 1.175 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.189495 | 0.722 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.189495 | 0.722 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.078076 | 1.107 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.080993 | 1.092 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.080993 | 1.092 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.213478 | 0.671 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.213478 | 0.671 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.086925 | 1.061 |
| R-HSA-167161 | HIV Transcription Initiation | 0.086925 | 1.061 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.086925 | 1.061 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.092984 | 1.032 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.042782 | 1.369 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.229073 | 0.640 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.099161 | 1.004 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.048411 | 1.315 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.102292 | 0.990 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.244361 | 0.612 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.057497 | 1.240 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.251892 | 0.599 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.251892 | 0.599 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.062321 | 1.205 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.281275 | 0.551 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.281275 | 0.551 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.281275 | 0.551 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.288440 | 0.540 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.288440 | 0.540 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.288440 | 0.540 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.288440 | 0.540 |
| R-HSA-5334118 | DNA methylation | 0.295534 | 0.529 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.092107 | 1.036 |
| R-HSA-167172 | Transcription of the HIV genome | 0.176654 | 0.753 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.080967 | 1.092 |
| R-HSA-72086 | mRNA Capping | 0.295534 | 0.529 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.131592 | 0.881 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.147899 | 0.830 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.173104 | 0.762 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.080993 | 1.092 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.111268 | 0.954 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.111268 | 0.954 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.289983 | 0.538 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.198192 | 0.703 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.051355 | 1.289 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.077807 | 1.109 |
| R-HSA-198753 | ERK/MAPK targets | 0.229073 | 0.640 |
| R-HSA-525793 | Myogenesis | 0.274039 | 0.562 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.189495 | 0.722 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.289983 | 0.538 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.282614 | 0.549 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.247578 | 0.606 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 0.095174 | 1.021 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.173104 | 0.762 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.072347 | 1.141 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.032585 | 1.487 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.213478 | 0.671 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.099161 | 1.004 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.244361 | 0.612 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.259348 | 0.586 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.281275 | 0.551 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.281275 | 0.551 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.087171 | 1.060 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.053491 | 1.272 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.048480 | 1.314 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.302558 | 0.519 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.169561 | 0.771 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.221314 | 0.655 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.173104 | 0.762 |
| R-HSA-162587 | HIV Life Cycle | 0.099696 | 1.001 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.121929 | 0.914 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.061331 | 1.212 |
| R-HSA-3214847 | HATs acetylate histones | 0.098919 | 1.005 |
| R-HSA-68875 | Mitotic Prophase | 0.046437 | 1.333 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.232921 | 0.633 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.086076 | 1.065 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 0.104181 | 0.982 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.139328 | 0.856 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.197569 | 0.704 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.274039 | 0.562 |
| R-HSA-191859 | snRNP Assembly | 0.145167 | 0.838 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.145167 | 0.838 |
| R-HSA-9609690 | HCMV Early Events | 0.169720 | 0.770 |
| R-HSA-162906 | HIV Infection | 0.235054 | 0.629 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.030371 | 1.518 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.274039 | 0.562 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.064027 | 1.194 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.212722 | 0.672 |
| R-HSA-1474165 | Reproduction | 0.180501 | 0.744 |
| R-HSA-2028269 | Signaling by Hippo | 0.197569 | 0.704 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.048769 | 1.312 |
| R-HSA-8932505 | DAG1 core M3 glycosylations | 0.130672 | 0.884 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.080993 | 1.092 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.080993 | 1.092 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.083943 | 1.076 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.295534 | 0.529 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.250239 | 0.602 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.076888 | 1.114 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.028345 | 1.548 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.147899 | 0.830 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.147899 | 0.830 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.147899 | 0.830 |
| R-HSA-196843 | Vitamin B2 (riboflavin) metabolism | 0.164786 | 0.783 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.173104 | 0.762 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.075194 | 1.124 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.102292 | 0.990 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.316397 | 0.500 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.278927 | 0.555 |
| R-HSA-9609646 | HCMV Infection | 0.285229 | 0.545 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.281275 | 0.551 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.056062 | 1.251 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.323214 | 0.491 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.134957 | 0.870 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.105021 | 0.979 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.099696 | 1.001 |
| R-HSA-390696 | Adrenoceptors | 0.104181 | 0.982 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.113099 | 0.947 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.189495 | 0.722 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.197569 | 0.704 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.078076 | 1.107 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.259348 | 0.586 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.309512 | 0.509 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.323214 | 0.491 |
| R-HSA-446728 | Cell junction organization | 0.079980 | 1.097 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.247578 | 0.606 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.138342 | 0.859 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.329963 | 0.482 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.323214 | 0.491 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.127550 | 0.894 |
| R-HSA-418990 | Adherens junctions interactions | 0.091826 | 1.037 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.293665 | 0.532 |
| R-HSA-9833110 | RSV-host interactions | 0.323000 | 0.491 |
| R-HSA-157579 | Telomere Maintenance | 0.293665 | 0.532 |
| R-HSA-1500931 | Cell-Cell communication | 0.122219 | 0.913 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.169720 | 0.770 |
| R-HSA-421270 | Cell-cell junction organization | 0.136862 | 0.864 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.095174 | 1.021 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.121929 | 0.914 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.164786 | 0.783 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.189495 | 0.722 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.083943 | 1.076 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.134957 | 0.870 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.281275 | 0.551 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.155531 | 0.808 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.295534 | 0.529 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.105021 | 0.979 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.158594 | 0.800 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.127550 | 0.894 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.127550 | 0.894 |
| R-HSA-5683826 | Surfactant metabolism | 0.096058 | 1.017 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.227352 | 0.643 |
| R-HSA-9758941 | Gastrulation | 0.026989 | 1.569 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.216044 | 0.665 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.266730 | 0.574 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.288440 | 0.540 |
| R-HSA-1989781 | PPARA activates gene expression | 0.096626 | 1.015 |
| R-HSA-73893 | DNA Damage Bypass | 0.111844 | 0.951 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.250109 | 0.602 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.306888 | 0.513 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.078076 | 1.107 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.156384 | 0.806 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.213478 | 0.671 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.329963 | 0.482 |
| R-HSA-168255 | Influenza Infection | 0.317773 | 0.498 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.113099 | 0.947 |
| R-HSA-211000 | Gene Silencing by RNA | 0.032316 | 1.491 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.178027 | 0.750 |
| R-HSA-4839726 | Chromatin organization | 0.283010 | 0.548 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.274039 | 0.562 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.293665 | 0.532 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.183793 | 0.736 |
| R-HSA-70171 | Glycolysis | 0.304693 | 0.516 |
| R-HSA-416476 | G alpha (q) signalling events | 0.316530 | 0.500 |
| R-HSA-162582 | Signal Transduction | 0.267738 | 0.572 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.034589 | 1.461 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.295534 | 0.529 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.134957 | 0.870 |
| R-HSA-422356 | Regulation of insulin secretion | 0.297344 | 0.527 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.329963 | 0.482 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.213478 | 0.671 |
| R-HSA-196807 | Nicotinate metabolism | 0.173101 | 0.762 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.323214 | 0.491 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.329963 | 0.482 |
| R-HSA-2262752 | Cellular responses to stress | 0.057219 | 1.242 |
| R-HSA-3371556 | Cellular response to heat stress | 0.153844 | 0.813 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.096058 | 1.017 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.266730 | 0.574 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.212722 | 0.672 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.060692 | 1.217 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.329963 | 0.482 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.054513 | 1.264 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.123540 | 0.908 |
| R-HSA-8931838 | DAG1 glycosylations | 0.316397 | 0.500 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.194579 | 0.711 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.144484 | 0.840 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.302558 | 0.519 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.263610 | 0.579 |
| R-HSA-201556 | Signaling by ALK | 0.078076 | 1.107 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.159017 | 0.799 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.146806 | 0.833 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.089152 | 1.050 |
| R-HSA-5357801 | Programmed Cell Death | 0.026369 | 1.579 |
| R-HSA-9830369 | Kidney development | 0.173101 | 0.762 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.216372 | 0.665 |
| R-HSA-622312 | Inflammasomes | 0.288440 | 0.540 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.205681 | 0.687 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.166033 | 0.780 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.316397 | 0.500 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.301020 | 0.521 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.205443 | 0.687 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.249419 | 0.603 |
| R-HSA-73894 | DNA Repair | 0.331540 | 0.479 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.336646 | 0.473 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.336646 | 0.473 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.339074 | 0.470 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.343262 | 0.464 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.343262 | 0.464 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.349813 | 0.456 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.349813 | 0.456 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.349813 | 0.456 |
| R-HSA-8853659 | RET signaling | 0.349813 | 0.456 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.352028 | 0.453 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.356298 | 0.448 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.356298 | 0.448 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.356298 | 0.448 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.356298 | 0.448 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.358585 | 0.445 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.359222 | 0.445 |
| R-HSA-73927 | Depurination | 0.362720 | 0.440 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.362720 | 0.440 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.369078 | 0.433 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.369078 | 0.433 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.369958 | 0.432 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.375372 | 0.426 |
| R-HSA-167169 | HIV Transcription Elongation | 0.375372 | 0.426 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.375372 | 0.426 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.375372 | 0.426 |
| R-HSA-68886 | M Phase | 0.376940 | 0.424 |
| R-HSA-70326 | Glucose metabolism | 0.377076 | 0.424 |
| R-HSA-5693538 | Homology Directed Repair | 0.380623 | 0.420 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.381605 | 0.418 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.381605 | 0.418 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.381605 | 0.418 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.381605 | 0.418 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.384161 | 0.415 |
| R-HSA-189451 | Heme biosynthesis | 0.387775 | 0.411 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.387775 | 0.411 |
| R-HSA-72172 | mRNA Splicing | 0.388326 | 0.411 |
| R-HSA-73886 | Chromosome Maintenance | 0.391212 | 0.408 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.391212 | 0.408 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.393884 | 0.405 |
| R-HSA-73928 | Depyrimidination | 0.393884 | 0.405 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.398227 | 0.400 |
| R-HSA-9710421 | Defective pyroptosis | 0.399933 | 0.398 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.401721 | 0.396 |
| R-HSA-373752 | Netrin-1 signaling | 0.405922 | 0.392 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.405922 | 0.392 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.405922 | 0.392 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.408679 | 0.389 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.408679 | 0.389 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.408679 | 0.389 |
| R-HSA-194138 | Signaling by VEGF | 0.408679 | 0.389 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.411851 | 0.385 |
| R-HSA-774815 | Nucleosome assembly | 0.411851 | 0.385 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.411851 | 0.385 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.411851 | 0.385 |
| R-HSA-114608 | Platelet degranulation | 0.415599 | 0.381 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.417722 | 0.379 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.417722 | 0.379 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.423534 | 0.373 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.429289 | 0.367 |
| R-HSA-9843745 | Adipogenesis | 0.432719 | 0.364 |
| R-HSA-5576891 | Cardiac conduction | 0.432719 | 0.364 |
| R-HSA-9766229 | Degradation of CDH1 | 0.434986 | 0.362 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.434986 | 0.362 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.436112 | 0.360 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.439493 | 0.357 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.440627 | 0.356 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.442433 | 0.354 |
| R-HSA-912446 | Meiotic recombination | 0.446212 | 0.350 |
| R-HSA-72187 | mRNA 3'-end processing | 0.451742 | 0.345 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.451742 | 0.345 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.451742 | 0.345 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.451742 | 0.345 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.451742 | 0.345 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.451742 | 0.345 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.451885 | 0.345 |
| R-HSA-163685 | Integration of energy metabolism | 0.452908 | 0.344 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.456233 | 0.341 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.457069 | 0.340 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.457216 | 0.340 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.457216 | 0.340 |
| R-HSA-1221632 | Meiotic synapsis | 0.457216 | 0.340 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.457216 | 0.340 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.457216 | 0.340 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.457216 | 0.340 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.462637 | 0.335 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.468003 | 0.330 |
| R-HSA-418597 | G alpha (z) signalling events | 0.468003 | 0.330 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.473317 | 0.325 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.473317 | 0.325 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.478577 | 0.320 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.483786 | 0.315 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.483786 | 0.315 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.483786 | 0.315 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.488942 | 0.311 |
| R-HSA-186712 | Regulation of beta-cell development | 0.488942 | 0.311 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.488942 | 0.311 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.494048 | 0.306 |
| R-HSA-983189 | Kinesins | 0.494048 | 0.306 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.494048 | 0.306 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.494048 | 0.306 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.494048 | 0.306 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.494048 | 0.306 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.494048 | 0.306 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.494048 | 0.306 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.494048 | 0.306 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.499102 | 0.302 |
| R-HSA-450294 | MAP kinase activation | 0.499102 | 0.302 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.499102 | 0.302 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.504107 | 0.297 |
| R-HSA-9707616 | Heme signaling | 0.504107 | 0.297 |
| R-HSA-1268020 | Mitochondrial protein import | 0.504107 | 0.297 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.504107 | 0.297 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.504679 | 0.297 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.505285 | 0.296 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.510927 | 0.292 |
| R-HSA-9609507 | Protein localization | 0.510927 | 0.292 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.513968 | 0.289 |
| R-HSA-73887 | Death Receptor Signaling | 0.514032 | 0.289 |
| R-HSA-9610379 | HCMV Late Events | 0.523268 | 0.281 |
| R-HSA-74160 | Gene expression (Transcription) | 0.525829 | 0.279 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.528394 | 0.277 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.528394 | 0.277 |
| R-HSA-877300 | Interferon gamma signaling | 0.529361 | 0.276 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.532387 | 0.274 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.533108 | 0.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.533108 | 0.273 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.535690 | 0.271 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.542395 | 0.266 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.542395 | 0.266 |
| R-HSA-448424 | Interleukin-17 signaling | 0.542395 | 0.266 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.542395 | 0.266 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.546970 | 0.262 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.546970 | 0.262 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.546970 | 0.262 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.546970 | 0.262 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.546970 | 0.262 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.546970 | 0.262 |
| R-HSA-189445 | Metabolism of porphyrins | 0.546970 | 0.262 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.551119 | 0.259 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.551499 | 0.258 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.551499 | 0.258 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.551499 | 0.258 |
| R-HSA-5619102 | SLC transporter disorders | 0.553202 | 0.257 |
| R-HSA-109582 | Hemostasis | 0.557531 | 0.254 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.560423 | 0.251 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.560423 | 0.251 |
| R-HSA-72306 | tRNA processing | 0.564802 | 0.248 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.564818 | 0.248 |
| R-HSA-8852135 | Protein ubiquitination | 0.564818 | 0.248 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.564818 | 0.248 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.569170 | 0.245 |
| R-HSA-5689603 | UCH proteinases | 0.569170 | 0.245 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.569170 | 0.245 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.570521 | 0.244 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.573479 | 0.241 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.573479 | 0.241 |
| R-HSA-913531 | Interferon Signaling | 0.576716 | 0.239 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.577744 | 0.238 |
| R-HSA-4086400 | PCP/CE pathway | 0.577744 | 0.238 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.577744 | 0.238 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.578998 | 0.237 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.586149 | 0.232 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.586149 | 0.232 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.586149 | 0.232 |
| R-HSA-9833482 | PKR-mediated signaling | 0.586149 | 0.232 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.590289 | 0.229 |
| R-HSA-977225 | Amyloid fiber formation | 0.590289 | 0.229 |
| R-HSA-1640170 | Cell Cycle | 0.596615 | 0.224 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.598445 | 0.223 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.601004 | 0.221 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.602463 | 0.220 |
| R-HSA-1500620 | Meiosis | 0.606440 | 0.217 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.606440 | 0.217 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.610378 | 0.214 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.610378 | 0.214 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.611854 | 0.213 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.614277 | 0.212 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.614277 | 0.212 |
| R-HSA-212436 | Generic Transcription Pathway | 0.615287 | 0.211 |
| R-HSA-195721 | Signaling by WNT | 0.618257 | 0.209 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.621959 | 0.206 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.623820 | 0.205 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.624721 | 0.204 |
| R-HSA-73884 | Base Excision Repair | 0.629488 | 0.201 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.633197 | 0.198 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.633197 | 0.198 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.640504 | 0.193 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.640504 | 0.193 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.644104 | 0.191 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.644882 | 0.191 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.644882 | 0.191 |
| R-HSA-1474290 | Collagen formation | 0.647667 | 0.189 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.652621 | 0.185 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.658146 | 0.182 |
| R-HSA-1296071 | Potassium Channels | 0.658146 | 0.182 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.664959 | 0.177 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.664959 | 0.177 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.664959 | 0.177 |
| R-HSA-190236 | Signaling by FGFR | 0.664959 | 0.177 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.668822 | 0.175 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.671637 | 0.173 |
| R-HSA-397014 | Muscle contraction | 0.675815 | 0.170 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.678183 | 0.169 |
| R-HSA-1483255 | PI Metabolism | 0.678183 | 0.169 |
| R-HSA-68882 | Mitotic Anaphase | 0.684886 | 0.164 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.687121 | 0.163 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.690888 | 0.161 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.690888 | 0.161 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.693986 | 0.159 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.700089 | 0.155 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.703095 | 0.153 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.703095 | 0.153 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.703095 | 0.153 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.703890 | 0.152 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.706071 | 0.151 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.706071 | 0.151 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.714822 | 0.146 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.714822 | 0.146 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.718858 | 0.143 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.723315 | 0.141 |
| R-HSA-9675108 | Nervous system development | 0.723922 | 0.140 |
| R-HSA-157118 | Signaling by NOTCH | 0.735033 | 0.134 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.736914 | 0.133 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.736914 | 0.133 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.740903 | 0.130 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.742166 | 0.129 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.744752 | 0.128 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.744752 | 0.128 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.747313 | 0.126 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.748329 | 0.126 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.749849 | 0.125 |
| R-HSA-69206 | G1/S Transition | 0.754844 | 0.122 |
| R-HSA-69481 | G2/M Checkpoints | 0.759740 | 0.119 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.762151 | 0.118 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.764585 | 0.117 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.768073 | 0.115 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.772699 | 0.112 |
| R-HSA-9909396 | Circadian clock | 0.773852 | 0.111 |
| R-HSA-449147 | Signaling by Interleukins | 0.777388 | 0.109 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.784981 | 0.105 |
| R-HSA-5173105 | O-linked glycosylation | 0.787140 | 0.104 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.793491 | 0.100 |
| R-HSA-9664407 | Parasite infection | 0.793491 | 0.100 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.793491 | 0.100 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.795565 | 0.099 |
| R-HSA-597592 | Post-translational protein modification | 0.799828 | 0.097 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.806545 | 0.093 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.807585 | 0.093 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.809519 | 0.092 |
| R-HSA-166520 | Signaling by NTRKs | 0.811434 | 0.091 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.811434 | 0.091 |
| R-HSA-69242 | S Phase | 0.811434 | 0.091 |
| R-HSA-9824446 | Viral Infection Pathways | 0.817597 | 0.087 |
| R-HSA-422475 | Axon guidance | 0.820655 | 0.086 |
| R-HSA-69306 | DNA Replication | 0.820723 | 0.086 |
| R-HSA-9679506 | SARS-CoV Infections | 0.830970 | 0.080 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.839590 | 0.076 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.856482 | 0.067 |
| R-HSA-8957322 | Metabolism of steroids | 0.860452 | 0.065 |
| R-HSA-8953854 | Metabolism of RNA | 0.861809 | 0.065 |
| R-HSA-611105 | Respiratory electron transport | 0.862176 | 0.064 |
| R-HSA-3781865 | Diseases of glycosylation | 0.870299 | 0.060 |
| R-HSA-5617833 | Cilium Assembly | 0.877946 | 0.057 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.879176 | 0.056 |
| R-HSA-68877 | Mitotic Prometaphase | 0.881599 | 0.055 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.891921 | 0.050 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.893011 | 0.049 |
| R-HSA-6805567 | Keratinization | 0.897263 | 0.047 |
| R-HSA-388396 | GPCR downstream signalling | 0.903163 | 0.044 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.913974 | 0.039 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.918649 | 0.037 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.924998 | 0.034 |
| R-HSA-392499 | Metabolism of proteins | 0.937518 | 0.028 |
| R-HSA-372790 | Signaling by GPCR | 0.942056 | 0.026 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.952066 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 0.952066 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.952888 | 0.021 |
| R-HSA-1483257 | Phospholipid metabolism | 0.958440 | 0.018 |
| R-HSA-1280218 | Adaptive Immune System | 0.959337 | 0.018 |
| R-HSA-199991 | Membrane Trafficking | 0.965278 | 0.015 |
| R-HSA-1474244 | Extracellular matrix organization | 0.971222 | 0.013 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.974019 | 0.011 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.975566 | 0.011 |
| R-HSA-5663205 | Infectious disease | 0.980765 | 0.008 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.985059 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.986926 | 0.006 |
| R-HSA-168256 | Immune System | 0.988530 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.988793 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.989355 | 0.005 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.990390 | 0.004 |
| R-HSA-6798695 | Neutrophil degranulation | 0.992183 | 0.003 |
| R-HSA-112316 | Neuronal System | 0.993021 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.993986 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.998006 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999474 | 0.000 |
| R-HSA-1643685 | Disease | 0.999618 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999624 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.820 | 0.542 | 1 | 0.884 |
CLK3 |
0.819 | 0.424 | 1 | 0.811 |
CDK18 |
0.817 | 0.534 | 1 | 0.906 |
HIPK4 |
0.816 | 0.458 | 1 | 0.809 |
CDK19 |
0.811 | 0.512 | 1 | 0.888 |
DYRK2 |
0.808 | 0.519 | 1 | 0.876 |
CDK7 |
0.807 | 0.500 | 1 | 0.912 |
KIS |
0.806 | 0.459 | 1 | 0.897 |
SRPK1 |
0.805 | 0.325 | -3 | 0.809 |
CDK17 |
0.805 | 0.512 | 1 | 0.888 |
CDK3 |
0.804 | 0.459 | 1 | 0.896 |
CDK8 |
0.804 | 0.495 | 1 | 0.889 |
JNK2 |
0.803 | 0.544 | 1 | 0.896 |
CDK5 |
0.803 | 0.496 | 1 | 0.913 |
CLK2 |
0.802 | 0.362 | -3 | 0.807 |
P38G |
0.801 | 0.527 | 1 | 0.885 |
HIPK1 |
0.801 | 0.492 | 1 | 0.876 |
CDK13 |
0.801 | 0.493 | 1 | 0.906 |
CDK1 |
0.799 | 0.475 | 1 | 0.905 |
DYRK4 |
0.799 | 0.504 | 1 | 0.892 |
P38D |
0.799 | 0.531 | 1 | 0.900 |
CDK12 |
0.798 | 0.496 | 1 | 0.899 |
P38B |
0.798 | 0.514 | 1 | 0.897 |
ERK1 |
0.797 | 0.498 | 1 | 0.900 |
CDK16 |
0.795 | 0.483 | 1 | 0.893 |
P38A |
0.794 | 0.499 | 1 | 0.902 |
CDK9 |
0.794 | 0.488 | 1 | 0.903 |
JNK3 |
0.794 | 0.522 | 1 | 0.898 |
CLK1 |
0.791 | 0.344 | -3 | 0.802 |
DYRK1B |
0.791 | 0.471 | 1 | 0.886 |
PRKD1 |
0.790 | 0.238 | -3 | 0.871 |
SRPK2 |
0.790 | 0.247 | -3 | 0.742 |
HIPK3 |
0.789 | 0.477 | 1 | 0.850 |
DYRK1A |
0.789 | 0.426 | 1 | 0.880 |
CLK4 |
0.789 | 0.315 | -3 | 0.823 |
CDK14 |
0.789 | 0.473 | 1 | 0.902 |
CDK10 |
0.788 | 0.449 | 1 | 0.906 |
MAK |
0.786 | 0.391 | -2 | 0.694 |
NLK |
0.786 | 0.417 | 1 | 0.821 |
ERK5 |
0.783 | 0.274 | 1 | 0.778 |
NDR2 |
0.783 | 0.116 | -3 | 0.888 |
ICK |
0.782 | 0.285 | -3 | 0.882 |
CDKL5 |
0.782 | 0.190 | -3 | 0.848 |
COT |
0.780 | 0.036 | 2 | 0.797 |
DYRK3 |
0.779 | 0.375 | 1 | 0.847 |
PRKD2 |
0.779 | 0.152 | -3 | 0.830 |
AURC |
0.779 | 0.125 | -2 | 0.598 |
MTOR |
0.777 | 0.141 | 1 | 0.654 |
PIM3 |
0.777 | 0.098 | -3 | 0.882 |
ERK2 |
0.775 | 0.442 | 1 | 0.900 |
JNK1 |
0.775 | 0.461 | 1 | 0.891 |
CDKL1 |
0.775 | 0.153 | -3 | 0.850 |
SRPK3 |
0.774 | 0.204 | -3 | 0.776 |
RSK2 |
0.774 | 0.103 | -3 | 0.835 |
SKMLCK |
0.773 | 0.131 | -2 | 0.781 |
CDK4 |
0.772 | 0.457 | 1 | 0.900 |
CDK2 |
0.772 | 0.337 | 1 | 0.872 |
CDC7 |
0.771 | 0.020 | 1 | 0.563 |
P90RSK |
0.770 | 0.098 | -3 | 0.835 |
CDK6 |
0.770 | 0.436 | 1 | 0.899 |
RSK3 |
0.770 | 0.093 | -3 | 0.823 |
NDR1 |
0.770 | 0.047 | -3 | 0.879 |
PIM1 |
0.768 | 0.100 | -3 | 0.838 |
MOK |
0.768 | 0.343 | 1 | 0.832 |
NEK6 |
0.766 | 0.038 | -2 | 0.726 |
LATS2 |
0.766 | 0.038 | -5 | 0.546 |
ATR |
0.766 | 0.035 | 1 | 0.617 |
MOS |
0.765 | 0.025 | 1 | 0.612 |
PRPK |
0.765 | 0.007 | -1 | 0.773 |
PKACB |
0.764 | 0.105 | -2 | 0.615 |
CHAK2 |
0.764 | 0.071 | -1 | 0.775 |
WNK1 |
0.763 | 0.036 | -2 | 0.787 |
PRP4 |
0.763 | 0.310 | -3 | 0.766 |
NUAK2 |
0.763 | 0.072 | -3 | 0.884 |
CAMK1B |
0.762 | 0.030 | -3 | 0.890 |
PKACG |
0.761 | 0.050 | -2 | 0.651 |
TSSK1 |
0.760 | 0.098 | -3 | 0.908 |
PAK6 |
0.760 | 0.116 | -2 | 0.616 |
MNK2 |
0.760 | 0.074 | -2 | 0.713 |
PKN3 |
0.760 | 0.023 | -3 | 0.865 |
MAPKAPK3 |
0.759 | 0.047 | -3 | 0.834 |
MARK4 |
0.759 | 0.061 | 4 | 0.783 |
PKCD |
0.759 | 0.046 | 2 | 0.689 |
MST4 |
0.759 | 0.017 | 2 | 0.789 |
RSK4 |
0.759 | 0.083 | -3 | 0.814 |
DAPK2 |
0.759 | 0.073 | -3 | 0.898 |
MAPKAPK2 |
0.759 | 0.057 | -3 | 0.797 |
GCN2 |
0.759 | -0.102 | 2 | 0.731 |
AKT2 |
0.759 | 0.112 | -3 | 0.759 |
PRKD3 |
0.758 | 0.088 | -3 | 0.799 |
PKCB |
0.758 | 0.071 | 2 | 0.657 |
CAMLCK |
0.758 | 0.052 | -2 | 0.738 |
DSTYK |
0.758 | -0.045 | 2 | 0.818 |
PDHK4 |
0.758 | -0.101 | 1 | 0.602 |
P70S6KB |
0.757 | 0.044 | -3 | 0.847 |
PAK1 |
0.757 | 0.057 | -2 | 0.700 |
NIK |
0.756 | 0.019 | -3 | 0.895 |
TBK1 |
0.756 | -0.074 | 1 | 0.463 |
BMPR2 |
0.756 | -0.083 | -2 | 0.725 |
PKN2 |
0.756 | 0.010 | -3 | 0.868 |
CAMK2D |
0.756 | 0.021 | -3 | 0.879 |
PRKX |
0.756 | 0.093 | -3 | 0.760 |
ULK2 |
0.756 | -0.060 | 2 | 0.697 |
RAF1 |
0.755 | -0.122 | 1 | 0.552 |
LATS1 |
0.755 | 0.082 | -3 | 0.903 |
TGFBR2 |
0.754 | -0.037 | -2 | 0.647 |
MLK2 |
0.754 | 0.042 | 2 | 0.740 |
AMPKA1 |
0.754 | 0.024 | -3 | 0.891 |
PAK3 |
0.754 | 0.041 | -2 | 0.692 |
SGK3 |
0.753 | 0.096 | -3 | 0.823 |
IKKE |
0.753 | -0.069 | 1 | 0.457 |
AMPKA2 |
0.753 | 0.045 | -3 | 0.869 |
IKKB |
0.753 | -0.106 | -2 | 0.572 |
MNK1 |
0.753 | 0.066 | -2 | 0.710 |
AURB |
0.753 | 0.048 | -2 | 0.590 |
PKG2 |
0.752 | 0.069 | -2 | 0.612 |
MPSK1 |
0.752 | 0.158 | 1 | 0.620 |
PKCZ |
0.752 | 0.048 | 2 | 0.695 |
TSSK2 |
0.752 | 0.051 | -5 | 0.611 |
NEK7 |
0.752 | -0.085 | -3 | 0.846 |
MSK1 |
0.752 | 0.064 | -3 | 0.808 |
PKCA |
0.751 | 0.040 | 2 | 0.638 |
QSK |
0.751 | 0.067 | 4 | 0.764 |
PKCG |
0.751 | 0.030 | 2 | 0.643 |
PDHK1 |
0.750 | -0.123 | 1 | 0.571 |
NIM1 |
0.750 | 0.023 | 3 | 0.670 |
IKKA |
0.750 | -0.014 | -2 | 0.568 |
MSK2 |
0.749 | 0.039 | -3 | 0.805 |
HUNK |
0.749 | -0.035 | 2 | 0.759 |
IRE1 |
0.749 | -0.034 | 1 | 0.558 |
CAMK2A |
0.748 | 0.035 | 2 | 0.735 |
NEK9 |
0.748 | -0.033 | 2 | 0.768 |
MASTL |
0.748 | -0.068 | -2 | 0.665 |
ERK7 |
0.748 | 0.159 | 2 | 0.470 |
BMPR1B |
0.748 | 0.039 | 1 | 0.528 |
DNAPK |
0.747 | 0.029 | 1 | 0.538 |
NUAK1 |
0.747 | 0.018 | -3 | 0.841 |
PHKG1 |
0.747 | 0.006 | -3 | 0.870 |
PIM2 |
0.746 | 0.063 | -3 | 0.807 |
CAMK2G |
0.746 | -0.111 | 2 | 0.735 |
DCAMKL1 |
0.746 | 0.070 | -3 | 0.837 |
RIPK3 |
0.746 | -0.108 | 3 | 0.653 |
PKACA |
0.746 | 0.077 | -2 | 0.580 |
MELK |
0.745 | 0.014 | -3 | 0.854 |
MLK3 |
0.744 | -0.029 | 2 | 0.655 |
MLK1 |
0.744 | -0.123 | 2 | 0.729 |
GRK5 |
0.743 | -0.126 | -3 | 0.839 |
NEK2 |
0.743 | 0.011 | 2 | 0.741 |
PKR |
0.743 | 0.009 | 1 | 0.586 |
CHK1 |
0.743 | 0.020 | -3 | 0.870 |
GRK1 |
0.742 | -0.034 | -2 | 0.587 |
SIK |
0.742 | 0.034 | -3 | 0.813 |
PKCH |
0.742 | 0.005 | 2 | 0.634 |
SMG1 |
0.742 | -0.007 | 1 | 0.587 |
ULK1 |
0.742 | -0.112 | -3 | 0.796 |
BCKDK |
0.742 | -0.122 | -1 | 0.705 |
CAMK2B |
0.741 | -0.015 | 2 | 0.720 |
AURA |
0.741 | 0.021 | -2 | 0.560 |
WNK3 |
0.741 | -0.177 | 1 | 0.552 |
TLK2 |
0.741 | 0.005 | 1 | 0.547 |
MARK3 |
0.741 | 0.036 | 4 | 0.714 |
VRK2 |
0.740 | 0.073 | 1 | 0.636 |
ALK4 |
0.740 | -0.020 | -2 | 0.692 |
GSK3A |
0.740 | 0.128 | 4 | 0.403 |
IRE2 |
0.739 | -0.066 | 2 | 0.647 |
TGFBR1 |
0.739 | -0.004 | -2 | 0.665 |
AKT3 |
0.739 | 0.094 | -3 | 0.705 |
AKT1 |
0.739 | 0.066 | -3 | 0.779 |
BRSK1 |
0.739 | 0.021 | -3 | 0.840 |
QIK |
0.739 | -0.039 | -3 | 0.873 |
ATM |
0.738 | -0.047 | 1 | 0.556 |
MYLK4 |
0.738 | 0.006 | -2 | 0.681 |
PAK5 |
0.738 | 0.050 | -2 | 0.558 |
PAK2 |
0.737 | -0.024 | -2 | 0.670 |
PAK4 |
0.737 | 0.069 | -2 | 0.565 |
BUB1 |
0.737 | 0.101 | -5 | 0.550 |
PKCT |
0.737 | 0.023 | 2 | 0.641 |
FAM20C |
0.737 | -0.009 | 2 | 0.562 |
PINK1 |
0.736 | 0.055 | 1 | 0.731 |
GRK7 |
0.736 | -0.028 | 1 | 0.543 |
CAMK4 |
0.736 | -0.089 | -3 | 0.861 |
BRSK2 |
0.736 | -0.015 | -3 | 0.859 |
WNK4 |
0.736 | -0.009 | -2 | 0.786 |
DLK |
0.735 | -0.186 | 1 | 0.552 |
CHAK1 |
0.735 | -0.067 | 2 | 0.683 |
MST3 |
0.735 | 0.027 | 2 | 0.772 |
YSK4 |
0.735 | -0.071 | 1 | 0.504 |
PASK |
0.734 | 0.040 | -3 | 0.898 |
RIPK1 |
0.734 | -0.175 | 1 | 0.539 |
NEK5 |
0.734 | 0.007 | 1 | 0.570 |
SGK1 |
0.734 | 0.097 | -3 | 0.690 |
ANKRD3 |
0.734 | -0.164 | 1 | 0.573 |
SSTK |
0.733 | 0.077 | 4 | 0.754 |
MARK2 |
0.733 | 0.003 | 4 | 0.683 |
PKCE |
0.732 | 0.045 | 2 | 0.634 |
MEK1 |
0.732 | -0.107 | 2 | 0.761 |
MAPKAPK5 |
0.732 | -0.016 | -3 | 0.780 |
PKCI |
0.731 | 0.007 | 2 | 0.656 |
TTBK2 |
0.731 | -0.144 | 2 | 0.648 |
LKB1 |
0.731 | 0.056 | -3 | 0.851 |
GRK6 |
0.731 | -0.145 | 1 | 0.545 |
TAO3 |
0.730 | 0.002 | 1 | 0.555 |
DCAMKL2 |
0.729 | -0.005 | -3 | 0.855 |
DRAK1 |
0.729 | -0.069 | 1 | 0.520 |
SBK |
0.728 | 0.124 | -3 | 0.650 |
IRAK4 |
0.728 | -0.056 | 1 | 0.535 |
MLK4 |
0.728 | -0.099 | 2 | 0.629 |
ACVR2B |
0.728 | -0.063 | -2 | 0.646 |
PBK |
0.728 | 0.083 | 1 | 0.588 |
DAPK3 |
0.728 | 0.041 | -3 | 0.850 |
ACVR2A |
0.728 | -0.067 | -2 | 0.634 |
ROCK2 |
0.727 | 0.075 | -3 | 0.844 |
P70S6K |
0.727 | -0.000 | -3 | 0.772 |
GRK4 |
0.727 | -0.173 | -2 | 0.643 |
TNIK |
0.726 | 0.069 | 3 | 0.806 |
PERK |
0.726 | -0.097 | -2 | 0.659 |
PLK4 |
0.726 | -0.082 | 2 | 0.549 |
PLK1 |
0.726 | -0.139 | -2 | 0.635 |
ALK2 |
0.726 | -0.055 | -2 | 0.654 |
SMMLCK |
0.726 | -0.010 | -3 | 0.858 |
MEKK1 |
0.726 | -0.093 | 1 | 0.536 |
CAMK1G |
0.725 | -0.040 | -3 | 0.812 |
PKN1 |
0.725 | 0.024 | -3 | 0.789 |
GSK3B |
0.725 | 0.026 | 4 | 0.397 |
MARK1 |
0.725 | -0.035 | 4 | 0.733 |
MEKK6 |
0.724 | 0.027 | 1 | 0.551 |
MRCKB |
0.724 | 0.051 | -3 | 0.795 |
MEK5 |
0.724 | -0.144 | 2 | 0.742 |
PHKG2 |
0.723 | -0.039 | -3 | 0.836 |
GCK |
0.723 | -0.005 | 1 | 0.557 |
MEKK2 |
0.723 | -0.081 | 2 | 0.725 |
KHS1 |
0.722 | 0.065 | 1 | 0.527 |
CK1E |
0.722 | -0.021 | -3 | 0.539 |
GAK |
0.722 | 0.004 | 1 | 0.632 |
PDK1 |
0.722 | 0.006 | 1 | 0.544 |
SNRK |
0.721 | -0.119 | 2 | 0.582 |
ZAK |
0.721 | -0.126 | 1 | 0.498 |
CAMK1D |
0.721 | -0.001 | -3 | 0.759 |
HRI |
0.721 | -0.151 | -2 | 0.698 |
HGK |
0.721 | 0.012 | 3 | 0.796 |
DAPK1 |
0.720 | 0.030 | -3 | 0.836 |
BMPR1A |
0.720 | -0.033 | 1 | 0.497 |
BRAF |
0.720 | -0.111 | -4 | 0.739 |
GRK2 |
0.720 | -0.087 | -2 | 0.552 |
MAP3K15 |
0.719 | 0.005 | 1 | 0.505 |
TLK1 |
0.719 | -0.117 | -2 | 0.687 |
KHS2 |
0.719 | 0.034 | 1 | 0.552 |
LOK |
0.718 | -0.001 | -2 | 0.627 |
HPK1 |
0.718 | -0.006 | 1 | 0.541 |
MRCKA |
0.718 | 0.017 | -3 | 0.813 |
HASPIN |
0.717 | 0.081 | -1 | 0.726 |
DMPK1 |
0.717 | 0.068 | -3 | 0.811 |
TAO2 |
0.717 | -0.055 | 2 | 0.763 |
PDHK3_TYR |
0.717 | 0.222 | 4 | 0.845 |
NEK11 |
0.717 | -0.100 | 1 | 0.541 |
NEK4 |
0.716 | -0.067 | 1 | 0.531 |
MINK |
0.716 | -0.020 | 1 | 0.526 |
LIMK2_TYR |
0.716 | 0.203 | -3 | 0.902 |
NEK1 |
0.716 | -0.024 | 1 | 0.534 |
LRRK2 |
0.716 | -0.005 | 2 | 0.766 |
CAMKK2 |
0.715 | -0.061 | -2 | 0.582 |
CK1G1 |
0.715 | -0.030 | -3 | 0.519 |
PLK3 |
0.715 | -0.145 | 2 | 0.700 |
CRIK |
0.714 | 0.055 | -3 | 0.778 |
CHK2 |
0.714 | 0.011 | -3 | 0.707 |
PKG1 |
0.713 | 0.025 | -2 | 0.551 |
NEK8 |
0.712 | -0.152 | 2 | 0.729 |
CAMKK1 |
0.712 | -0.117 | -2 | 0.573 |
MEKK3 |
0.711 | -0.223 | 1 | 0.535 |
CK1D |
0.710 | -0.032 | -3 | 0.486 |
ROCK1 |
0.710 | 0.040 | -3 | 0.809 |
EEF2K |
0.709 | -0.053 | 3 | 0.741 |
SLK |
0.709 | -0.057 | -2 | 0.561 |
CAMK1A |
0.708 | -0.002 | -3 | 0.715 |
PKMYT1_TYR |
0.707 | 0.160 | 3 | 0.771 |
CK1A2 |
0.707 | -0.037 | -3 | 0.488 |
YSK1 |
0.707 | -0.034 | 2 | 0.740 |
MST2 |
0.707 | -0.118 | 1 | 0.533 |
TESK1_TYR |
0.707 | 0.055 | 3 | 0.794 |
VRK1 |
0.706 | -0.076 | 2 | 0.753 |
NEK3 |
0.706 | -0.030 | 1 | 0.509 |
MAP2K4_TYR |
0.705 | 0.066 | -1 | 0.779 |
TAK1 |
0.705 | -0.127 | 1 | 0.556 |
MYO3B |
0.704 | 0.010 | 2 | 0.744 |
GRK3 |
0.704 | -0.090 | -2 | 0.512 |
MAP2K6_TYR |
0.702 | 0.019 | -1 | 0.785 |
CK2A2 |
0.702 | -0.076 | 1 | 0.476 |
PDHK4_TYR |
0.701 | -0.016 | 2 | 0.791 |
IRAK1 |
0.701 | -0.218 | -1 | 0.687 |
STK33 |
0.700 | -0.110 | 2 | 0.534 |
OSR1 |
0.700 | -0.037 | 2 | 0.722 |
MEK2 |
0.700 | -0.130 | 2 | 0.735 |
AAK1 |
0.699 | 0.051 | 1 | 0.527 |
BIKE |
0.699 | 0.002 | 1 | 0.567 |
MST1 |
0.698 | -0.140 | 1 | 0.520 |
MAP2K7_TYR |
0.697 | -0.087 | 2 | 0.775 |
LIMK1_TYR |
0.696 | 0.003 | 2 | 0.763 |
TTBK1 |
0.695 | -0.195 | 2 | 0.560 |
PDHK1_TYR |
0.693 | -0.083 | -1 | 0.767 |
TTK |
0.693 | -0.087 | -2 | 0.660 |
CK2A1 |
0.692 | -0.077 | 1 | 0.461 |
BMPR2_TYR |
0.692 | -0.061 | -1 | 0.738 |
PINK1_TYR |
0.692 | -0.151 | 1 | 0.600 |
RET |
0.692 | -0.067 | 1 | 0.545 |
TNK2 |
0.692 | 0.009 | 3 | 0.718 |
TNK1 |
0.692 | 0.031 | 3 | 0.712 |
TAO1 |
0.692 | -0.058 | 1 | 0.480 |
EPHA6 |
0.691 | 0.003 | -1 | 0.691 |
ABL2 |
0.691 | 0.005 | -1 | 0.671 |
ROS1 |
0.690 | -0.040 | 3 | 0.698 |
ASK1 |
0.690 | -0.069 | 1 | 0.489 |
MYO3A |
0.689 | -0.066 | 1 | 0.532 |
MST1R |
0.689 | -0.078 | 3 | 0.755 |
TNNI3K_TYR |
0.689 | 0.037 | 1 | 0.548 |
PLK2 |
0.688 | -0.106 | -3 | 0.755 |
JAK2 |
0.688 | -0.050 | 1 | 0.536 |
ABL1 |
0.688 | 0.000 | -1 | 0.664 |
EPHB4 |
0.687 | -0.047 | -1 | 0.672 |
TYRO3 |
0.687 | -0.095 | 3 | 0.726 |
FGR |
0.687 | -0.063 | 1 | 0.583 |
CSF1R |
0.686 | -0.051 | 3 | 0.727 |
DDR1 |
0.686 | -0.074 | 4 | 0.757 |
YANK3 |
0.685 | -0.055 | 2 | 0.352 |
TYK2 |
0.684 | -0.142 | 1 | 0.529 |
NEK10_TYR |
0.684 | -0.054 | 1 | 0.479 |
TXK |
0.682 | -0.030 | 1 | 0.543 |
RIPK2 |
0.682 | -0.254 | 1 | 0.458 |
YES1 |
0.681 | -0.086 | -1 | 0.721 |
JAK1 |
0.681 | -0.035 | 1 | 0.478 |
JAK3 |
0.679 | -0.119 | 1 | 0.523 |
LCK |
0.678 | -0.061 | -1 | 0.678 |
BLK |
0.677 | -0.048 | -1 | 0.680 |
FER |
0.677 | -0.139 | 1 | 0.573 |
DDR2 |
0.677 | -0.008 | 3 | 0.663 |
ITK |
0.675 | -0.097 | -1 | 0.661 |
HCK |
0.675 | -0.108 | -1 | 0.680 |
CK1A |
0.674 | -0.054 | -3 | 0.391 |
FGFR2 |
0.674 | -0.117 | 3 | 0.711 |
KDR |
0.674 | -0.110 | 3 | 0.683 |
MERTK |
0.674 | -0.081 | 3 | 0.710 |
INSRR |
0.673 | -0.143 | 3 | 0.665 |
EPHA4 |
0.673 | -0.094 | 2 | 0.701 |
SRMS |
0.672 | -0.136 | 1 | 0.535 |
MET |
0.671 | -0.100 | 3 | 0.738 |
AXL |
0.671 | -0.123 | 3 | 0.700 |
KIT |
0.671 | -0.131 | 3 | 0.723 |
TEK |
0.670 | -0.115 | 3 | 0.663 |
FGFR1 |
0.670 | -0.099 | 3 | 0.684 |
EPHB3 |
0.670 | -0.114 | -1 | 0.650 |
EPHB1 |
0.669 | -0.144 | 1 | 0.525 |
PDGFRB |
0.669 | -0.191 | 3 | 0.727 |
EPHB2 |
0.668 | -0.113 | -1 | 0.637 |
WEE1_TYR |
0.668 | -0.101 | -1 | 0.648 |
EPHA1 |
0.668 | -0.087 | 3 | 0.725 |
STLK3 |
0.667 | -0.168 | 1 | 0.472 |
BMX |
0.667 | -0.092 | -1 | 0.576 |
FLT3 |
0.666 | -0.186 | 3 | 0.729 |
FYN |
0.665 | -0.086 | -1 | 0.656 |
PTK2B |
0.665 | -0.060 | -1 | 0.640 |
ALPHAK3 |
0.664 | -0.183 | -1 | 0.654 |
ALK |
0.663 | -0.139 | 3 | 0.651 |
PDGFRA |
0.662 | -0.208 | 3 | 0.728 |
LTK |
0.662 | -0.141 | 3 | 0.675 |
TEC |
0.662 | -0.151 | -1 | 0.592 |
EPHA7 |
0.662 | -0.115 | 2 | 0.696 |
BTK |
0.661 | -0.199 | -1 | 0.639 |
FGFR3 |
0.660 | -0.140 | 3 | 0.683 |
PTK6 |
0.660 | -0.182 | -1 | 0.613 |
FRK |
0.660 | -0.131 | -1 | 0.678 |
INSR |
0.658 | -0.149 | 3 | 0.659 |
MATK |
0.658 | -0.112 | -1 | 0.603 |
EPHA3 |
0.658 | -0.154 | 2 | 0.668 |
NTRK3 |
0.657 | -0.131 | -1 | 0.645 |
LYN |
0.656 | -0.143 | 3 | 0.638 |
NTRK1 |
0.656 | -0.221 | -1 | 0.686 |
FLT1 |
0.655 | -0.190 | -1 | 0.668 |
CSK |
0.654 | -0.128 | 2 | 0.699 |
SRC |
0.653 | -0.127 | -1 | 0.657 |
ERBB2 |
0.652 | -0.203 | 1 | 0.492 |
EPHA8 |
0.652 | -0.125 | -1 | 0.622 |
NTRK2 |
0.651 | -0.236 | 3 | 0.667 |
PTK2 |
0.651 | -0.075 | -1 | 0.612 |
EPHA5 |
0.650 | -0.151 | 2 | 0.680 |
FLT4 |
0.650 | -0.222 | 3 | 0.666 |
YANK2 |
0.648 | -0.086 | 2 | 0.360 |
FGFR4 |
0.646 | -0.138 | -1 | 0.616 |
EGFR |
0.645 | -0.136 | 1 | 0.413 |
MUSK |
0.644 | -0.139 | 1 | 0.418 |
CK1G3 |
0.642 | -0.085 | -3 | 0.342 |
SYK |
0.641 | -0.118 | -1 | 0.605 |
EPHA2 |
0.640 | -0.137 | -1 | 0.583 |
IGF1R |
0.638 | -0.179 | 3 | 0.592 |
ZAP70 |
0.637 | -0.065 | -1 | 0.558 |
ERBB4 |
0.637 | -0.113 | 1 | 0.422 |
FES |
0.628 | -0.152 | -1 | 0.554 |
CK1G2 |
0.628 | -0.093 | -3 | 0.436 |