Motif 301 (n=211)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NI28 | ARHGAP42 | S789 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| D6RIA3 | C4orf54 | S1345 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| O00116 | AGPS | S589 | ochoa | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| O00192 | ARVCF | S902 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00571 | DDX3X | S489 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14686 | KMT2D | S3463 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15067 | PFAS | S128 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15127 | SCAMP2 | S310 | ochoa | Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15503 | INSIG1 | S125 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O15523 | DDX3Y | S487 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43399 | TPD52L2 | S21 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43707 | ACTN4 | S262 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O43815 | STRN | S229 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60566 | BUB1B | S270 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60749 | SNX2 | S226 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75152 | ZC3H11A | S688 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75179 | ANKRD17 | S206 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75362 | ZNF217 | S820 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | S1912 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1697 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75569 | PRKRA | S287 | psp | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O75582 | RPS6KA5 | S376 | ochoa|psp | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O94811 | TPPP | S32 | ochoa|psp | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
| O94868 | FCHSD2 | S530 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O95235 | KIF20A | S670 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P02675 | FGB | S67 | ochoa | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P06733 | ENO1 | S27 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07741 | APRT | S30 | ochoa | Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. {ECO:0000269|PubMed:15196008}. |
| P08758 | ANXA5 | S44 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P12814 | ACTN1 | S243 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P19878 | NCF2 | S213 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P20810 | CAST | S526 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P22102 | GART | S434 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P23193 | TCEA1 | S139 | ochoa | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
| P25054 | APC | S873 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25100 | ADRA1D | S300 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P25100 | ADRA1D | S334 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P26599 | PTBP1 | T138 | psp | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}. |
| P27708 | CAD | S1407 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P32780 | GTF2H1 | S290 | ochoa | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}. |
| P33121 | ACSL1 | S423 | ochoa | Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| P35348 | ADRA1A | S258 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35408 | PTGER4 | S222 | ochoa | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P35523 | CLCN1 | S892 | psp | Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle) | Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (PubMed:12456816, PubMed:16027167, PubMed:22521272, PubMed:22641783, PubMed:26007199, PubMed:26502825, PubMed:26510092, PubMed:7951242, PubMed:8112288, PubMed:8130334, PubMed:9122265, PubMed:9565403, PubMed:9736777). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (PubMed:10051520, PubMed:10962018, PubMed:29809153, PubMed:31022181). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:9122265, PubMed:9565403). {ECO:0000269|PubMed:10051520, ECO:0000269|PubMed:10962018, ECO:0000269|PubMed:12456816, ECO:0000269|PubMed:16027167, ECO:0000269|PubMed:22521272, ECO:0000269|PubMed:22641783, ECO:0000269|PubMed:26007199, ECO:0000269|PubMed:26502825, ECO:0000269|PubMed:26510092, ECO:0000269|PubMed:29809153, ECO:0000269|PubMed:31022181, ECO:0000269|PubMed:7951242, ECO:0000269|PubMed:8112288, ECO:0000269|PubMed:8130334, ECO:0000269|PubMed:9122265, ECO:0000269|PubMed:9565403, ECO:0000269|PubMed:9736777}. |
| P40189 | IL6ST | S862 | ochoa | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:19915009, PubMed:2261637, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}. |
| P40227 | CCT6A | S428 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P41146 | OPRL1 | S346 | psp | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) | G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}. |
| P42345 | MTOR | S1418 | ochoa|psp | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P43243 | MATR3 | S41 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46087 | NOP2 | S40 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46459 | NSF | S106 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P48382 | RFX5 | S312 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49759 | CLK1 | S341 | ochoa | Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
| P52292 | KPNA2 | S87 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P52292 | KPNA2 | S88 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P54136 | RARS1 | S378 | ochoa | Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269|PubMed:17443684, ECO:0000269|PubMed:25288775}. |
| P54296 | MYOM2 | S462 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54578 | USP14 | S143 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55196 | AFDN | S551 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56545 | CTBP2 | S164 | ochoa|psp | C-terminal-binding protein 2 (CtBP2) | Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 probably acts as a scaffold for specialized synapses. |
| P61019 | RAB2A | S67 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P61764 | STXBP1 | S89 | ochoa | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P78348 | ASIC1 | S499 | psp | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). {ECO:0000250|UniProtKB:Q6NXK8, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232}.; FUNCTION: [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster (PubMed:21036899). Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present (PubMed:21036899). Also potentially permeable to lithium and potassium (PubMed:21036899). {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. {ECO:0000269|PubMed:21036899}. |
| P98175 | RBM10 | S492 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q03001 | DST | S7464 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03111 | MLLT1 | S414 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q07352 | ZFP36L1 | S203 | psp | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q12959 | DLG1 | S517 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13015 | MLLT11 | S43 | ochoa | Protein AF1q | Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. |
| Q13136 | PPFIA1 | S549 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13363 | CTBP1 | S158 | ochoa|psp | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Q13428 | TCOF1 | S846 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13459 | MYO9B | S1331 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13506 | NAB1 | S183 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q13671 | RIN1 | S356 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14160 | SCRIB | S1276 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14498 | RBM39 | Y475 | psp | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q14669 | TRIP12 | S1113 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q15111 | PLCL1 | S47 | ochoa | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}. |
| Q16555 | DPYSL2 | S288 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q29RF7 | PDS5A | S1232 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2M1V0 | ISX | S183 | psp | Intestine-specific homeobox (RAX-like homeobox) | Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). {ECO:0000250}. |
| Q3V6T2 | CCDC88A | S1837 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q460N5 | PARP14 | S823 | ochoa | Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:18851833, PubMed:25043379, PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). {ECO:0000269|PubMed:16061477, ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:27796300, ECO:0000305|PubMed:29858569}. |
| Q49A26 | GLYR1 | S186 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q49A26 | GLYR1 | S187 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q58EX7 | PLEKHG4 | S685 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5BKX6 | SLC45A4 | S411 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5H9R7 | PPP6R3 | S817 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JTH9 | RRP12 | S118 | ochoa | RRP12-like protein | None |
| Q5S007 | LRRK2 | S2032 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5T1M5 | FKBP15 | S1139 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T1V6 | DDX59 | S37 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q68CJ9 | CREB3L3 | S360 | psp | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}. |
| Q68DK2 | ZFYVE26 | S1742 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q6AWC2 | WWC2 | S515 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6FI81 | CIAPIN1 | S182 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6IA86 | ELP2 | S122 | ochoa | Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}. |
| Q6KC79 | NIPBL | S255 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6KC79 | NIPBL | S256 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PCB0 | VWA1 | S92 | ochoa | von Willebrand factor A domain-containing protein 1 | Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (Probable). {ECO:0000250|UniProtKB:Q8R2Z5, ECO:0000305|PubMed:33559681}. |
| Q6TDP4 | KLHL17 | S374 | ochoa | Kelch-like protein 17 (Actinfilin) | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). {ECO:0000250}. |
| Q6ZNB6 | NFXL1 | S47 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q6ZU35 | CRACD | S874 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q71F56 | MED13L | S777 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q71RC2 | LARP4 | S594 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7KZ85 | SUPT6H | S1666 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7Z3K3 | POGZ | S704 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z4H3 | HDDC2 | S185 | ochoa | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}. |
| Q7Z4S6 | KIF21A | S855 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6Z7 | HUWE1 | S3317 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86VQ1 | GLCCI1 | S76 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86VR2 | RETREG3 | S26 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86XP1 | DGKH | S695 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q86YW5 | TREML1 | S211 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IWE2 | FAM114A1 | S25 | ochoa | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | May play a role in neuronal cell development. {ECO:0000250}. |
| Q8IWZ3 | ANKHD1 | S177 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IY26 | PLPP6 | S63 | ochoa | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}. |
| Q8IY63 | AMOTL1 | S787 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IZ07 | ANKRD13A | S510 | ochoa | Ankyrin repeat domain-containing protein 13A (Protein KE03) | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}. |
| Q8IZT6 | ASPM | S2806 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N122 | RPTOR | S606 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N137 | CNTROB | S41 | psp | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8N1S5 | SLC39A11 | S153 | ochoa | Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) | Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q8BWY7}. |
| Q8N350 | CBARP | S328 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N7J2 | AMER2 | S233 | ochoa | APC membrane recruitment protein 2 (Amer2) (Protein FAM123A) | Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}. |
| Q8TDD1 | DDX54 | S696 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TDM6 | DLG5 | S1236 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TE77 | SSH3 | S602 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8TEH3 | DENND1A | S554 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TEJ3 | SH3RF3 | S438 | ochoa | E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4) | Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}. |
| Q8WUD1 | RAB2B | S67 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q92835 | INPP5D | S1085 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92932 | PTPRN2 | S652 | ochoa | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}. |
| Q96AG4 | LRRC59 | S25 | ochoa | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}. |
| Q96HB5 | CCDC120 | S358 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96IF1 | AJUBA | S237 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96II8 | LRCH3 | S65 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96JM2 | ZNF462 | S2169 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96N67 | DOCK7 | S927 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NY7 | CLIC6 | S303 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q96PE2 | ARHGEF17 | S733 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96RG2 | PASK | S19 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RG2 | PASK | S579 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T37 | RBM15 | S344 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99698 | LYST | S2245 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99952 | PTPN18 | S390 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q99959 | PKP2 | S313 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q99988 | GDF15 | S97 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BT23 | LIMD2 | S29 | ochoa | LIM domain-containing protein 2 | Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809). {ECO:0000269|PubMed:24590809}. |
| Q9BTC0 | DIDO1 | S1456 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUH8 | BEGAIN | S483 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BUR4 | WRAP53 | S125 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BV36 | MLPH | S484 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BV73 | CEP250 | S2392 | ochoa|psp | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BXF6 | RAB11FIP5 | S564 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXI6 | TBC1D10A | S20 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BY77 | POLDIP3 | S44 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BYV9 | BACH2 | S315 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9BZ23 | PANK2 | S140 | ochoa | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}. |
| Q9BZE2 | PUS3 | S142 | ochoa | tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) | Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. {ECO:0000269|PubMed:27055666}. |
| Q9H2G2 | SLK | S543 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2K8 | TAOK3 | S424 | ochoa | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
| Q9H334 | FOXP1 | S37 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H5I5 | PIEZO2 | S1718 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H6R4 | NOL6 | S811 | ochoa | Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}. |
| Q9H9B1 | EHMT1 | S38 | ochoa | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. |
| Q9HAZ1 | CLK4 | S339 | ochoa | Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. |
| Q9NQT8 | KIF13B | S1795 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NRH2 | SNRK | S383 | ochoa | SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) | May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}. |
| Q9NV58 | RNF19A | S282 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NWV8 | BABAM1 | S44 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NZM3 | ITSN2 | S957 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P1A6 | DLGAP2 | S668 | ochoa | Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9P244 | LRFN1 | S731 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9UBC2 | EPS15L1 | S593 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UGN4 | CD300A | S269 | ochoa | CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}. |
| Q9UJA5 | TRMT6 | S475 | ochoa | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}. |
| Q9UJF2 | RASAL2 | S893 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKT8 | FBXW2 | S245 | ochoa | F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
| Q9ULG1 | INO80 | S468 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9ULV3 | CIZ1 | S821 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMZ2 | SYNRG | S648 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNF1 | MAGED2 | S85 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| Q9Y2U8 | LEMD3 | S327 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3I0 | RTCB | S300 | ochoa | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) | Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:21311021, ECO:0000269|PubMed:24870230}. |
| Q9Y467 | SALL2 | S806 | ochoa | Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2) | Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. {ECO:0000269|PubMed:24412933}. |
| Q9Y490 | TLN1 | S1583 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4J8 | DTNA | S609 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y6D9 | MAD1L1 | S77 | ochoa | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| P17301 | ITGA2 | S797 | Sugiyama | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}. |
| P34932 | HSPA4 | S40 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P60174 | TPI1 | S106 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q9Y230 | RUVBL2 | S43 | Sugiyama | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:10428817, ECO:0000269|PubMed:10882073, ECO:0000269|PubMed:11713276, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16014379, ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:17157868, ECO:0000269|PubMed:21303910, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:25652260, ECO:0000269|PubMed:28561026, ECO:0000269|PubMed:33205750}. |
| P41221 | WNT5A | S132 | Sugiyama | Protein Wnt-5a | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:Q27Q52, ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}. |
| Q9H1J7 | WNT5B | S111 | Sugiyama | Protein Wnt-5b | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}. |
| Q14697 | GANAB | S187 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| Q9Y639 | NPTN | S224 | Sugiyama | Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). {ECO:0000250|UniProtKB:P97546, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:30190470}. |
| P09769 | FGR | S418 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P29401 | TKT | S449 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| Q99575 | POP1 | Y101 | Sugiyama | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| P41279 | MAP3K8 | S368 | Sugiyama | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
| P42685 | FRK | S324 | Sugiyama | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P49768 | PSEN1 | S397 | GPS6 | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| O75128 | COBL | S1171 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| P11388 | TOP2A | S390 | Sugiyama | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P49917 | LIG4 | S199 | GPS6|ELM|iPTMNet|EPSD | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:12517771, PubMed:17290226, PubMed:23523427, PubMed:29980672, PubMed:33586762, PubMed:8798671, PubMed:9242410, PubMed:9809069). Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:12517771, PubMed:17290226, PubMed:9242410, PubMed:9809069). LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226). Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069). Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421). LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242). {ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:23523427, ECO:0000269|PubMed:24984242, ECO:0000269|PubMed:29980672, ECO:0000269|PubMed:33586762, ECO:0000269|PubMed:8798671, ECO:0000269|PubMed:9242410, ECO:0000269|PubMed:9809069}. |
| P11586 | MTHFD1 | S413 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| Q7KZF4 | SND1 | S52 | Sugiyama | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q8NEZ2 | VPS37A | S326 | Sugiyama | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
| Q9H6Y2 | WDR55 | S42 | Sugiyama | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.000443 | 3.354 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.000896 | 3.048 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.001399 | 2.854 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.001994 | 2.700 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.002814 | 2.551 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.004637 | 2.334 |
| R-HSA-447038 | NrCAM interactions | 0.004699 | 2.328 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014243 | 1.846 |
| R-HSA-9734195 | Defective APRT disrupts adenine salvage | 0.042126 | 1.375 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.009323 | 2.030 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.069224 | 1.160 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.069224 | 1.160 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.069224 | 1.160 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.015320 | 1.815 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.015320 | 1.815 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.108446 | 0.965 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.108446 | 0.965 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.007195 | 2.143 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.007195 | 2.143 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.033975 | 1.469 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.040356 | 1.394 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.158194 | 0.801 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.170193 | 0.769 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.170193 | 0.769 |
| R-HSA-4839744 | Signaling by APC mutants | 0.182022 | 0.740 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.182022 | 0.740 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.182022 | 0.740 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.182022 | 0.740 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.011427 | 1.942 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.069722 | 1.157 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.193682 | 0.713 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.205178 | 0.688 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.205178 | 0.688 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.205178 | 0.688 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.205178 | 0.688 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.205178 | 0.688 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.227681 | 0.643 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.238693 | 0.622 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.238693 | 0.622 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.249549 | 0.603 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.260251 | 0.585 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.088767 | 1.052 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.311524 | 0.507 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.311524 | 0.507 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.181986 | 0.740 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.321346 | 0.493 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.340573 | 0.468 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.340573 | 0.468 |
| R-HSA-72187 | mRNA 3'-end processing | 0.213081 | 0.671 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.213081 | 0.671 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.234083 | 0.631 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.244631 | 0.611 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.323730 | 0.490 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.334168 | 0.476 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.052616 | 1.279 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.052616 | 1.279 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.052616 | 1.279 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.170193 | 0.769 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.099506 | 1.002 |
| R-HSA-354192 | Integrin signaling | 0.108570 | 0.964 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.013358 | 1.874 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.050647 | 1.295 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.236771 | 0.626 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.249549 | 0.603 |
| R-HSA-9664420 | Killing mechanisms | 0.249549 | 0.603 |
| R-HSA-167172 | Transcription of the HIV genome | 0.297470 | 0.527 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.012075 | 1.918 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.082085 | 1.086 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.331029 | 0.480 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.176870 | 0.752 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.117843 | 0.929 |
| R-HSA-4086400 | PCP/CE pathway | 0.127442 | 0.895 |
| R-HSA-6798695 | Neutrophil degranulation | 0.250240 | 0.602 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.102985 | 0.987 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.121151 | 0.917 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.133676 | 0.874 |
| R-HSA-164843 | 2-LTR circle formation | 0.170193 | 0.769 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 0.061859 | 1.209 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.260251 | 0.585 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.132104 | 0.879 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.281202 | 0.551 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.156660 | 0.805 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.017893 | 1.747 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.306094 | 0.514 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.232995 | 0.633 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.232995 | 0.633 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.121151 | 0.917 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.227681 | 0.643 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.031361 | 1.504 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.156660 | 0.805 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.176870 | 0.752 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.181986 | 0.740 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.181986 | 0.740 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.181986 | 0.740 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.349736 | 0.456 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.009566 | 2.019 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.150357 | 0.823 |
| R-HSA-391251 | Protein folding | 0.060519 | 1.218 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.103424 | 0.985 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.011427 | 1.942 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.042126 | 1.375 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.017602 | 1.754 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.108446 | 0.965 |
| R-HSA-199920 | CREB phosphorylation | 0.121151 | 0.917 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.146023 | 0.836 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.043703 | 1.359 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.065751 | 1.182 |
| R-HSA-75896 | Plasmalogen biosynthesis | 0.193682 | 0.713 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.193682 | 0.713 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.193682 | 0.713 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.216510 | 0.665 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.099506 | 1.002 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.146732 | 0.833 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.146732 | 0.833 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.161671 | 0.791 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.331029 | 0.480 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.339370 | 0.469 |
| R-HSA-68877 | Mitotic Prometaphase | 0.362050 | 0.441 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.181986 | 0.740 |
| R-HSA-9620244 | Long-term potentiation | 0.010445 | 1.981 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.291454 | 0.535 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.170193 | 0.769 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.170193 | 0.769 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.061859 | 1.209 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.227681 | 0.643 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.255198 | 0.593 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.125872 | 0.900 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.205178 | 0.688 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.125872 | 0.900 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.133349 | 0.875 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.359258 | 0.445 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.133349 | 0.875 |
| R-HSA-450294 | MAP kinase activation | 0.260486 | 0.584 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.069468 | 1.158 |
| R-HSA-162587 | HIV Life Cycle | 0.244073 | 0.612 |
| R-HSA-165159 | MTOR signalling | 0.161671 | 0.791 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.122918 | 0.910 |
| R-HSA-195721 | Signaling by WNT | 0.175056 | 0.757 |
| R-HSA-448424 | Interleukin-17 signaling | 0.307998 | 0.511 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.037112 | 1.430 |
| R-HSA-9734207 | Nucleotide salvage defects | 0.146023 | 0.836 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.146023 | 0.836 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.158194 | 0.801 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.054326 | 1.265 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.170193 | 0.769 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.069722 | 1.157 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.193682 | 0.713 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.082085 | 1.086 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.086345 | 1.064 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.216510 | 0.665 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.281202 | 0.551 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.281202 | 0.551 |
| R-HSA-167169 | HIV Transcription Elongation | 0.146732 | 0.833 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.368402 | 0.434 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.192281 | 0.716 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.034255 | 1.465 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.058471 | 1.233 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007623 | 2.118 |
| R-HSA-4641265 | Repression of WNT target genes | 0.022567 | 1.647 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.019144 | 1.718 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.216510 | 0.665 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.095058 | 1.022 |
| R-HSA-180786 | Extension of Telomeres | 0.072908 | 1.137 |
| R-HSA-198753 | ERK/MAPK targets | 0.311524 | 0.507 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.265775 | 0.575 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.081052 | 1.091 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.127442 | 0.895 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.216706 | 0.664 |
| R-HSA-390696 | Adrenoceptors | 0.011176 | 1.952 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.020019 | 1.699 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.007195 | 2.143 |
| R-HSA-9683686 | Maturation of spike protein | 0.170193 | 0.769 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.170193 | 0.769 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.061859 | 1.209 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.077892 | 1.109 |
| R-HSA-8875878 | MET promotes cell motility | 0.136942 | 0.863 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.349982 | 0.456 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.218316 | 0.661 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.218316 | 0.661 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.260486 | 0.584 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.271063 | 0.567 |
| R-HSA-68886 | M Phase | 0.224412 | 0.649 |
| R-HSA-216083 | Integrin cell surface interactions | 0.349736 | 0.456 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.151680 | 0.819 |
| R-HSA-157579 | Telomere Maintenance | 0.203232 | 0.692 |
| R-HSA-112316 | Neuronal System | 0.051239 | 1.290 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.248163 | 0.605 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.151680 | 0.819 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.119039 | 0.924 |
| R-HSA-199991 | Membrane Trafficking | 0.167405 | 0.776 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.193682 | 0.713 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.108570 | 0.964 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.164965 | 0.783 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.122918 | 0.910 |
| R-HSA-8953854 | Metabolism of RNA | 0.346101 | 0.461 |
| R-HSA-983189 | Kinesins | 0.075456 | 1.122 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.032564 | 1.487 |
| R-HSA-73886 | Chromosome Maintenance | 0.306094 | 0.514 |
| R-HSA-3371556 | Cellular response to heat stress | 0.306094 | 0.514 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.146732 | 0.833 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.108446 | 0.965 |
| R-HSA-447041 | CHL1 interactions | 0.133676 | 0.874 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.146023 | 0.836 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.158194 | 0.801 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.158194 | 0.801 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 0.193682 | 0.713 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.205178 | 0.688 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.205178 | 0.688 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.205178 | 0.688 |
| R-HSA-9735804 | Diseases of nucleotide metabolism | 0.216510 | 0.665 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.141818 | 0.848 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 0.301561 | 0.521 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.368402 | 0.434 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.206903 | 0.684 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.229229 | 0.640 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.290537 | 0.537 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.206903 | 0.684 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.206903 | 0.684 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.132642 | 0.877 |
| R-HSA-75153 | Apoptotic execution phase | 0.181986 | 0.740 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.121151 | 0.917 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.307998 | 0.511 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.251979 | 0.599 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.255804 | 0.592 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.249549 | 0.603 |
| R-HSA-114608 | Platelet degranulation | 0.017439 | 1.758 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.050647 | 1.295 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.255804 | 0.592 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.236771 | 0.626 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.349736 | 0.456 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.244073 | 0.612 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.050691 | 1.295 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.249549 | 0.603 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.075456 | 1.122 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.281202 | 0.551 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.331029 | 0.480 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.340573 | 0.468 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.267326 | 0.573 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.278908 | 0.555 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.171315 | 0.766 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.192281 | 0.716 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.170193 | 0.769 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.311524 | 0.507 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.284668 | 0.546 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.292197 | 0.534 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.108446 | 0.965 |
| R-HSA-210990 | PECAM1 interactions | 0.182022 | 0.740 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.026110 | 1.583 |
| R-HSA-162592 | Integration of provirus | 0.193682 | 0.713 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.227681 | 0.643 |
| R-HSA-196783 | Coenzyme A biosynthesis | 0.260251 | 0.585 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.021469 | 1.668 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.321346 | 0.493 |
| R-HSA-437239 | Recycling pathway of L1 | 0.187123 | 0.728 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.368402 | 0.434 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.313251 | 0.504 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.355580 | 0.449 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.301561 | 0.521 |
| R-HSA-1640170 | Cell Cycle | 0.062008 | 1.208 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.224708 | 0.648 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.328954 | 0.483 |
| R-HSA-3000170 | Syndecan interactions | 0.065751 | 1.182 |
| R-HSA-2028269 | Signaling by Hippo | 0.270801 | 0.567 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.331029 | 0.480 |
| R-HSA-3000157 | Laminin interactions | 0.359258 | 0.445 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.255198 | 0.593 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.329719 | 0.482 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.216510 | 0.665 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.249549 | 0.603 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.102985 | 0.987 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.321346 | 0.493 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.207859 | 0.682 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.318495 | 0.497 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.334168 | 0.476 |
| R-HSA-1989781 | PPARA activates gene expression | 0.237922 | 0.624 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.228767 | 0.641 |
| R-HSA-70263 | Gluconeogenesis | 0.192281 | 0.716 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.323730 | 0.490 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.360452 | 0.443 |
| R-HSA-8939211 | ESR-mediated signaling | 0.309723 | 0.509 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.182022 | 0.740 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.216510 | 0.665 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.276139 | 0.559 |
| R-HSA-109582 | Hemostasis | 0.267947 | 0.572 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.339370 | 0.469 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.238693 | 0.622 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 0.368402 | 0.434 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.297576 | 0.526 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.297576 | 0.526 |
| R-HSA-373755 | Semaphorin interactions | 0.271063 | 0.567 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.255198 | 0.593 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.255198 | 0.593 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.255198 | 0.593 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.255198 | 0.593 |
| R-HSA-162582 | Signal Transduction | 0.053324 | 1.273 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.301381 | 0.521 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.303978 | 0.517 |
| R-HSA-446728 | Cell junction organization | 0.139321 | 0.856 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.043703 | 1.359 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.349982 | 0.456 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.349982 | 0.456 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.349982 | 0.456 |
| R-HSA-1500931 | Cell-Cell communication | 0.113027 | 0.947 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.242953 | 0.614 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.281202 | 0.551 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.166711 | 0.778 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.171778 | 0.765 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.321346 | 0.493 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.360046 | 0.444 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.156660 | 0.805 |
| R-HSA-1474244 | Extracellular matrix organization | 0.134765 | 0.870 |
| R-HSA-418990 | Adherens junctions interactions | 0.257631 | 0.589 |
| R-HSA-373753 | Nephrin family interactions | 0.050691 | 1.295 |
| R-HSA-4839726 | Chromatin organization | 0.343372 | 0.464 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.178870 | 0.747 |
| R-HSA-421270 | Cell-cell junction organization | 0.349011 | 0.457 |
| R-HSA-1538133 | G0 and Early G1 | 0.104011 | 0.983 |
| R-HSA-373760 | L1CAM interactions | 0.040609 | 1.391 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.095058 | 1.022 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.291454 | 0.535 |
| R-HSA-72306 | tRNA processing | 0.288006 | 0.541 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.301561 | 0.521 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.344559 | 0.463 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.360046 | 0.444 |
| R-HSA-6806834 | Signaling by MET | 0.360046 | 0.444 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.340573 | 0.468 |
| R-HSA-9675108 | Nervous system development | 0.365702 | 0.437 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.286919 | 0.542 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.311524 | 0.507 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.255198 | 0.593 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.171778 | 0.765 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.307998 | 0.511 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.303098 | 0.518 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.303978 | 0.517 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.370297 | 0.431 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.371751 | 0.430 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.376142 | 0.425 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.377415 | 0.423 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.377415 | 0.423 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.377415 | 0.423 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.377415 | 0.423 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.380482 | 0.420 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.380482 | 0.420 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.384669 | 0.415 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.386301 | 0.413 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.386301 | 0.413 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.386301 | 0.413 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.386301 | 0.413 |
| R-HSA-6807070 | PTEN Regulation | 0.387724 | 0.411 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.387724 | 0.411 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.390598 | 0.408 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.390598 | 0.408 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.390598 | 0.408 |
| R-HSA-72086 | mRNA Capping | 0.395060 | 0.403 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.395060 | 0.403 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.395060 | 0.403 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.395060 | 0.403 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.395628 | 0.403 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.403084 | 0.395 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.403695 | 0.394 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.403695 | 0.394 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.403695 | 0.394 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.406908 | 0.391 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.411343 | 0.386 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.412208 | 0.385 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.412208 | 0.385 |
| R-HSA-182971 | EGFR downregulation | 0.412208 | 0.385 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.415555 | 0.381 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.420599 | 0.376 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.420599 | 0.376 |
| R-HSA-422475 | Axon guidance | 0.424394 | 0.372 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.425395 | 0.371 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.427995 | 0.369 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.428871 | 0.368 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.428871 | 0.368 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.429562 | 0.367 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.430283 | 0.366 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.433458 | 0.363 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.436389 | 0.360 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.437025 | 0.359 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.437025 | 0.359 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.437025 | 0.359 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.437025 | 0.359 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.437025 | 0.359 |
| R-HSA-68882 | Mitotic Anaphase | 0.439082 | 0.357 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.442246 | 0.354 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.444706 | 0.352 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.445063 | 0.352 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.445063 | 0.352 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.445063 | 0.352 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.445063 | 0.352 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.445063 | 0.352 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.445063 | 0.352 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.445063 | 0.352 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.448436 | 0.348 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.452987 | 0.344 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.454387 | 0.343 |
| R-HSA-9612973 | Autophagy | 0.455866 | 0.341 |
| R-HSA-111933 | Calmodulin induced events | 0.460799 | 0.336 |
| R-HSA-111997 | CaM pathway | 0.460799 | 0.336 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.460799 | 0.336 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.460799 | 0.336 |
| R-HSA-9711097 | Cellular response to starvation | 0.463255 | 0.334 |
| R-HSA-73894 | DNA Repair | 0.463617 | 0.334 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.468499 | 0.329 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.468499 | 0.329 |
| R-HSA-3214847 | HATs acetylate histones | 0.468567 | 0.329 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.468567 | 0.329 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.471104 | 0.327 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.473246 | 0.325 |
| R-HSA-70171 | Glycolysis | 0.473246 | 0.325 |
| R-HSA-162906 | HIV Infection | 0.473571 | 0.325 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.476090 | 0.322 |
| R-HSA-74217 | Purine salvage | 0.476090 | 0.322 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.476090 | 0.322 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.477899 | 0.321 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.483573 | 0.316 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.483573 | 0.316 |
| R-HSA-71336 | Pentose phosphate pathway | 0.483573 | 0.316 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.483573 | 0.316 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.483573 | 0.316 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.485152 | 0.314 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.490949 | 0.309 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.490949 | 0.309 |
| R-HSA-5260271 | Diseases of Immune System | 0.490949 | 0.309 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.490949 | 0.309 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.490949 | 0.309 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.491708 | 0.308 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.498221 | 0.303 |
| R-HSA-9694548 | Maturation of spike protein | 0.498221 | 0.303 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.498221 | 0.303 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.498221 | 0.303 |
| R-HSA-15869 | Metabolism of nucleotides | 0.501193 | 0.300 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.505286 | 0.296 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.505389 | 0.296 |
| R-HSA-167161 | HIV Transcription Initiation | 0.505389 | 0.296 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.505389 | 0.296 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.505389 | 0.296 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.512455 | 0.290 |
| R-HSA-111996 | Ca-dependent events | 0.512455 | 0.290 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.512455 | 0.290 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.514207 | 0.289 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.514207 | 0.289 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.518628 | 0.285 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.519421 | 0.284 |
| R-HSA-8854214 | TBC/RABGAPs | 0.519421 | 0.284 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.519421 | 0.284 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.533057 | 0.273 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.533057 | 0.273 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.533057 | 0.273 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.539729 | 0.268 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.539729 | 0.268 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.540328 | 0.267 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.546307 | 0.263 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.546307 | 0.263 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.546307 | 0.263 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.546307 | 0.263 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.548818 | 0.261 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.552791 | 0.257 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.552791 | 0.257 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.553022 | 0.257 |
| R-HSA-5688426 | Deubiquitination | 0.557308 | 0.254 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.559182 | 0.252 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.559182 | 0.252 |
| R-HSA-70326 | Glucose metabolism | 0.561346 | 0.251 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.565466 | 0.248 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.565483 | 0.248 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.571350 | 0.243 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.571694 | 0.243 |
| R-HSA-68875 | Mitotic Prophase | 0.573624 | 0.241 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.577662 | 0.238 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.577817 | 0.238 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.577817 | 0.238 |
| R-HSA-449147 | Signaling by Interleukins | 0.582283 | 0.235 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.583853 | 0.234 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.583853 | 0.234 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.583853 | 0.234 |
| R-HSA-1221632 | Meiotic synapsis | 0.583853 | 0.234 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.583853 | 0.234 |
| R-HSA-72649 | Translation initiation complex formation | 0.589802 | 0.229 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.589802 | 0.229 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.590678 | 0.229 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.593700 | 0.226 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.594971 | 0.226 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.595667 | 0.225 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.595667 | 0.225 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.595667 | 0.225 |
| R-HSA-194138 | Signaling by VEGF | 0.597428 | 0.224 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.601449 | 0.221 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.601449 | 0.221 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.601449 | 0.221 |
| R-HSA-177929 | Signaling by EGFR | 0.601449 | 0.221 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.601449 | 0.221 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.601449 | 0.221 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.607148 | 0.217 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.608953 | 0.215 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.612766 | 0.213 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.612766 | 0.213 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.612766 | 0.213 |
| R-HSA-9033241 | Peroxisomal protein import | 0.618304 | 0.209 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.618304 | 0.209 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.618304 | 0.209 |
| R-HSA-379724 | tRNA Aminoacylation | 0.623763 | 0.205 |
| R-HSA-977443 | GABA receptor activation | 0.623763 | 0.205 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.623763 | 0.205 |
| R-HSA-9843745 | Adipogenesis | 0.623928 | 0.205 |
| R-HSA-72172 | mRNA Splicing | 0.624633 | 0.204 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.627602 | 0.202 |
| R-HSA-112043 | PLC beta mediated events | 0.629144 | 0.201 |
| R-HSA-8956321 | Nucleotide salvage | 0.629144 | 0.201 |
| R-HSA-9707616 | Heme signaling | 0.634449 | 0.198 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.634449 | 0.198 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.634449 | 0.198 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.634449 | 0.198 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.639678 | 0.194 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.639678 | 0.194 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.639678 | 0.194 |
| R-HSA-8848021 | Signaling by PTK6 | 0.639678 | 0.194 |
| R-HSA-163685 | Integration of energy metabolism | 0.645556 | 0.190 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.649914 | 0.187 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.654923 | 0.184 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.659424 | 0.181 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.659424 | 0.181 |
| R-HSA-9664407 | Parasite infection | 0.659424 | 0.181 |
| R-HSA-112040 | G-protein mediated events | 0.659861 | 0.181 |
| R-HSA-196807 | Nicotinate metabolism | 0.659861 | 0.181 |
| R-HSA-1632852 | Macroautophagy | 0.662822 | 0.179 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.663369 | 0.178 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.664728 | 0.177 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.664728 | 0.177 |
| R-HSA-1280218 | Adaptive Immune System | 0.672730 | 0.172 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.678917 | 0.168 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.678917 | 0.168 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.678917 | 0.168 |
| R-HSA-3000178 | ECM proteoglycans | 0.678917 | 0.168 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.678917 | 0.168 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.682645 | 0.166 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.683513 | 0.165 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.683513 | 0.165 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.685855 | 0.164 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.688043 | 0.162 |
| R-HSA-4086398 | Ca2+ pathway | 0.688043 | 0.162 |
| R-HSA-166520 | Signaling by NTRKs | 0.689039 | 0.162 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.692508 | 0.160 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.692508 | 0.160 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.692508 | 0.160 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.694450 | 0.158 |
| R-HSA-380287 | Centrosome maturation | 0.696910 | 0.157 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.697028 | 0.157 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.698431 | 0.156 |
| R-HSA-5689603 | UCH proteinases | 0.701250 | 0.154 |
| R-HSA-72312 | rRNA processing | 0.702136 | 0.154 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.705527 | 0.151 |
| R-HSA-73887 | Death Receptor Signaling | 0.707587 | 0.150 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.709743 | 0.149 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.709743 | 0.149 |
| R-HSA-9659379 | Sensory processing of sound | 0.713899 | 0.146 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.713899 | 0.146 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.717996 | 0.144 |
| R-HSA-9833482 | PKR-mediated signaling | 0.717996 | 0.144 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.717996 | 0.144 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.722035 | 0.141 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.722035 | 0.141 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.725208 | 0.140 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.725208 | 0.140 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.726016 | 0.139 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.729940 | 0.137 |
| R-HSA-109581 | Apoptosis | 0.730879 | 0.136 |
| R-HSA-2262752 | Cellular responses to stress | 0.732613 | 0.135 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.736452 | 0.133 |
| R-HSA-1500620 | Meiosis | 0.737621 | 0.132 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.748737 | 0.126 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.752337 | 0.124 |
| R-HSA-156902 | Peptide chain elongation | 0.752337 | 0.124 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.752337 | 0.124 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.755189 | 0.122 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.755886 | 0.122 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.759384 | 0.120 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.759384 | 0.120 |
| R-HSA-202424 | Downstream TCR signaling | 0.759384 | 0.120 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.762674 | 0.118 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.762832 | 0.118 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.762832 | 0.118 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.765373 | 0.116 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.766231 | 0.116 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.769582 | 0.114 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.769582 | 0.114 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.769582 | 0.114 |
| R-HSA-2029481 | FCGR activation | 0.772884 | 0.112 |
| R-HSA-416476 | G alpha (q) signalling events | 0.775144 | 0.111 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.776140 | 0.110 |
| R-HSA-1474290 | Collagen formation | 0.776140 | 0.110 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.777063 | 0.110 |
| R-HSA-168255 | Influenza Infection | 0.777587 | 0.109 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.779349 | 0.108 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.782512 | 0.107 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.782512 | 0.107 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.785630 | 0.105 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.788704 | 0.103 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.791734 | 0.101 |
| R-HSA-422356 | Regulation of insulin secretion | 0.791734 | 0.101 |
| R-HSA-190236 | Signaling by FGFR | 0.791734 | 0.101 |
| R-HSA-69275 | G2/M Transition | 0.793754 | 0.100 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.798179 | 0.098 |
| R-HSA-983712 | Ion channel transport | 0.800361 | 0.097 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.800566 | 0.097 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.800566 | 0.097 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.803426 | 0.095 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.803426 | 0.095 |
| R-HSA-1483255 | PI Metabolism | 0.803426 | 0.095 |
| R-HSA-192823 | Viral mRNA Translation | 0.806246 | 0.094 |
| R-HSA-9658195 | Leishmania infection | 0.807589 | 0.093 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.807589 | 0.093 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.809025 | 0.092 |
| R-HSA-111885 | Opioid Signalling | 0.809025 | 0.092 |
| R-HSA-9833110 | RSV-host interactions | 0.811764 | 0.091 |
| R-HSA-418346 | Platelet homeostasis | 0.817126 | 0.088 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.819750 | 0.086 |
| R-HSA-211000 | Gene Silencing by RNA | 0.819750 | 0.086 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.819750 | 0.086 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.819750 | 0.086 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.822337 | 0.085 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.822337 | 0.085 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.826873 | 0.083 |
| R-HSA-202403 | TCR signaling | 0.827399 | 0.082 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.828602 | 0.082 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.828776 | 0.082 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.832318 | 0.080 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.832318 | 0.080 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.832318 | 0.080 |
| R-HSA-5357801 | Programmed Cell Death | 0.834372 | 0.079 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.837097 | 0.077 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.839435 | 0.076 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.846252 | 0.073 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.846252 | 0.073 |
| R-HSA-397014 | Muscle contraction | 0.846796 | 0.072 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.848078 | 0.072 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.848459 | 0.071 |
| R-HSA-5693538 | Homology Directed Repair | 0.850635 | 0.070 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.856978 | 0.067 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.860217 | 0.065 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.861057 | 0.065 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.861057 | 0.065 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.861057 | 0.065 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.863053 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.866741 | 0.062 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.868871 | 0.061 |
| R-HSA-69481 | G2/M Checkpoints | 0.870755 | 0.060 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.872079 | 0.059 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.876247 | 0.057 |
| R-HSA-1474165 | Reproduction | 0.878026 | 0.056 |
| R-HSA-168249 | Innate Immune System | 0.878912 | 0.056 |
| R-HSA-9909396 | Circadian clock | 0.881507 | 0.055 |
| R-HSA-157118 | Signaling by NOTCH | 0.888469 | 0.051 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.891368 | 0.050 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.892930 | 0.049 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.897483 | 0.047 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.900411 | 0.046 |
| R-HSA-9609646 | HCMV Infection | 0.900621 | 0.045 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.907311 | 0.042 |
| R-HSA-69242 | S Phase | 0.908705 | 0.042 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.913848 | 0.039 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.914729 | 0.039 |
| R-HSA-9609507 | Protein localization | 0.915088 | 0.039 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.917515 | 0.037 |
| R-HSA-9610379 | HCMV Late Events | 0.919873 | 0.036 |
| R-HSA-913531 | Interferon Signaling | 0.930692 | 0.031 |
| R-HSA-168256 | Immune System | 0.935108 | 0.029 |
| R-HSA-418555 | G alpha (s) signalling events | 0.935545 | 0.029 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.935545 | 0.029 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.937389 | 0.028 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.937389 | 0.028 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.937389 | 0.028 |
| R-HSA-372790 | Signaling by GPCR | 0.938632 | 0.028 |
| R-HSA-500792 | GPCR ligand binding | 0.939501 | 0.027 |
| R-HSA-388396 | GPCR downstream signalling | 0.941101 | 0.026 |
| R-HSA-2559583 | Cellular Senescence | 0.943441 | 0.025 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.948162 | 0.023 |
| R-HSA-5617833 | Cilium Assembly | 0.951090 | 0.022 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.954216 | 0.020 |
| R-HSA-9609690 | HCMV Early Events | 0.955175 | 0.020 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.956749 | 0.019 |
| R-HSA-8957322 | Metabolism of steroids | 0.958803 | 0.018 |
| R-HSA-6805567 | Keratinization | 0.961802 | 0.017 |
| R-HSA-1266738 | Developmental Biology | 0.965399 | 0.015 |
| R-HSA-9679506 | SARS-CoV Infections | 0.966824 | 0.015 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.968075 | 0.014 |
| R-HSA-8951664 | Neddylation | 0.969294 | 0.014 |
| R-HSA-9824446 | Viral Infection Pathways | 0.970265 | 0.013 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.971451 | 0.013 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.975680 | 0.011 |
| R-HSA-418594 | G alpha (i) signalling events | 0.985504 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.985504 | 0.006 |
| R-HSA-72766 | Translation | 0.989042 | 0.005 |
| R-HSA-1483257 | Phospholipid metabolism | 0.989575 | 0.005 |
| R-HSA-74160 | Gene expression (Transcription) | 0.990090 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.994237 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.996456 | 0.002 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.997376 | 0.001 |
| R-HSA-1643685 | Disease | 0.997445 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.997452 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998523 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999086 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999536 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999722 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999762 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999952 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.879 | 0.070 | 2 | 0.827 |
PRKD1 |
0.875 | 0.302 | -3 | 0.878 |
NUAK2 |
0.874 | 0.251 | -3 | 0.890 |
PRKD2 |
0.874 | 0.294 | -3 | 0.832 |
PIM3 |
0.874 | 0.179 | -3 | 0.888 |
CDC7 |
0.873 | 0.067 | 1 | 0.822 |
WNK1 |
0.873 | 0.219 | -2 | 0.879 |
RSK2 |
0.873 | 0.235 | -3 | 0.846 |
CDKL1 |
0.872 | 0.227 | -3 | 0.876 |
CDKL5 |
0.872 | 0.239 | -3 | 0.872 |
CAMK1B |
0.872 | 0.200 | -3 | 0.910 |
CLK3 |
0.871 | 0.185 | 1 | 0.797 |
NDR2 |
0.870 | 0.123 | -3 | 0.876 |
PKN3 |
0.870 | 0.191 | -3 | 0.885 |
MOS |
0.869 | 0.087 | 1 | 0.851 |
HIPK4 |
0.869 | 0.198 | 1 | 0.773 |
NLK |
0.869 | 0.117 | 1 | 0.804 |
MST4 |
0.868 | 0.176 | 2 | 0.859 |
RAF1 |
0.868 | 0.020 | 1 | 0.833 |
PKN2 |
0.868 | 0.209 | -3 | 0.884 |
RSK3 |
0.867 | 0.205 | -3 | 0.840 |
PRPK |
0.867 | -0.105 | -1 | 0.840 |
NDR1 |
0.866 | 0.133 | -3 | 0.882 |
SRPK1 |
0.866 | 0.202 | -3 | 0.832 |
AMPKA1 |
0.866 | 0.202 | -3 | 0.893 |
P90RSK |
0.865 | 0.188 | -3 | 0.849 |
PIM1 |
0.865 | 0.223 | -3 | 0.847 |
AURC |
0.865 | 0.221 | -2 | 0.704 |
CAMLCK |
0.865 | 0.186 | -2 | 0.875 |
SKMLCK |
0.865 | 0.167 | -2 | 0.869 |
TSSK1 |
0.864 | 0.258 | -3 | 0.908 |
MAPKAPK3 |
0.864 | 0.181 | -3 | 0.841 |
TSSK2 |
0.864 | 0.241 | -5 | 0.907 |
MTOR |
0.863 | -0.067 | 1 | 0.762 |
NIK |
0.863 | 0.171 | -3 | 0.910 |
ERK5 |
0.863 | 0.086 | 1 | 0.785 |
IKKB |
0.863 | -0.078 | -2 | 0.781 |
PRKD3 |
0.863 | 0.276 | -3 | 0.813 |
GCN2 |
0.862 | -0.139 | 2 | 0.766 |
DSTYK |
0.862 | -0.011 | 2 | 0.857 |
AMPKA2 |
0.862 | 0.207 | -3 | 0.870 |
TBK1 |
0.862 | -0.052 | 1 | 0.744 |
MARK4 |
0.861 | 0.108 | 4 | 0.896 |
RIPK3 |
0.861 | 0.032 | 3 | 0.780 |
ATR |
0.861 | 0.002 | 1 | 0.804 |
DAPK2 |
0.861 | 0.172 | -3 | 0.911 |
ICK |
0.860 | 0.182 | -3 | 0.900 |
TGFBR2 |
0.860 | 0.021 | -2 | 0.792 |
PDHK4 |
0.860 | -0.215 | 1 | 0.837 |
PKCD |
0.860 | 0.170 | 2 | 0.766 |
BMPR2 |
0.860 | -0.138 | -2 | 0.883 |
PKACG |
0.860 | 0.154 | -2 | 0.773 |
CAMK2D |
0.859 | 0.105 | -3 | 0.889 |
ULK2 |
0.859 | -0.120 | 2 | 0.739 |
MAPKAPK2 |
0.859 | 0.177 | -3 | 0.804 |
P70S6KB |
0.859 | 0.146 | -3 | 0.860 |
CAMK2G |
0.858 | -0.084 | 2 | 0.770 |
SRPK2 |
0.858 | 0.188 | -3 | 0.766 |
LATS2 |
0.858 | 0.083 | -5 | 0.756 |
IKKE |
0.858 | -0.084 | 1 | 0.743 |
PDHK1 |
0.857 | -0.138 | 1 | 0.825 |
MNK2 |
0.857 | 0.169 | -2 | 0.820 |
WNK3 |
0.856 | -0.053 | 1 | 0.809 |
NUAK1 |
0.856 | 0.171 | -3 | 0.849 |
MLK1 |
0.855 | -0.032 | 2 | 0.798 |
NEK6 |
0.855 | -0.036 | -2 | 0.845 |
HUNK |
0.855 | -0.050 | 2 | 0.769 |
MELK |
0.855 | 0.168 | -3 | 0.860 |
AURB |
0.854 | 0.185 | -2 | 0.706 |
NIM1 |
0.854 | 0.059 | 3 | 0.820 |
IRE1 |
0.854 | 0.055 | 1 | 0.786 |
KIS |
0.854 | 0.048 | 1 | 0.658 |
NEK7 |
0.853 | -0.117 | -3 | 0.849 |
CAMK4 |
0.853 | 0.093 | -3 | 0.865 |
SRPK3 |
0.852 | 0.160 | -3 | 0.806 |
PKCB |
0.852 | 0.156 | 2 | 0.730 |
QIK |
0.852 | 0.101 | -3 | 0.875 |
MYLK4 |
0.852 | 0.180 | -2 | 0.803 |
CLK4 |
0.851 | 0.193 | -3 | 0.835 |
PKG2 |
0.851 | 0.179 | -2 | 0.714 |
DYRK2 |
0.851 | 0.116 | 1 | 0.673 |
AKT2 |
0.851 | 0.225 | -3 | 0.771 |
PKCA |
0.851 | 0.161 | 2 | 0.725 |
PHKG1 |
0.851 | 0.125 | -3 | 0.870 |
QSK |
0.851 | 0.141 | 4 | 0.884 |
CHAK2 |
0.851 | -0.039 | -1 | 0.840 |
RSK4 |
0.851 | 0.181 | -3 | 0.814 |
GRK5 |
0.851 | -0.164 | -3 | 0.860 |
PKACB |
0.851 | 0.203 | -2 | 0.715 |
CLK1 |
0.850 | 0.198 | -3 | 0.815 |
PKCG |
0.850 | 0.128 | 2 | 0.728 |
PAK6 |
0.850 | 0.149 | -2 | 0.762 |
PIM2 |
0.850 | 0.213 | -3 | 0.822 |
RIPK1 |
0.850 | -0.049 | 1 | 0.802 |
SGK3 |
0.850 | 0.206 | -3 | 0.833 |
BCKDK |
0.850 | -0.125 | -1 | 0.788 |
PAK1 |
0.850 | 0.098 | -2 | 0.824 |
MSK2 |
0.850 | 0.130 | -3 | 0.820 |
PKR |
0.850 | 0.128 | 1 | 0.830 |
PAK3 |
0.849 | 0.073 | -2 | 0.820 |
NEK9 |
0.849 | -0.062 | 2 | 0.810 |
MASTL |
0.849 | -0.184 | -2 | 0.825 |
MSK1 |
0.849 | 0.176 | -3 | 0.826 |
SIK |
0.849 | 0.151 | -3 | 0.817 |
CAMK2A |
0.848 | 0.108 | 2 | 0.761 |
ANKRD3 |
0.848 | -0.059 | 1 | 0.850 |
LATS1 |
0.848 | 0.108 | -3 | 0.888 |
CHK1 |
0.847 | 0.169 | -3 | 0.866 |
CAMK2B |
0.847 | 0.086 | 2 | 0.736 |
MLK2 |
0.847 | -0.054 | 2 | 0.777 |
FAM20C |
0.847 | 0.077 | 2 | 0.613 |
HIPK1 |
0.847 | 0.175 | 1 | 0.691 |
MNK1 |
0.847 | 0.129 | -2 | 0.826 |
GRK1 |
0.847 | -0.008 | -2 | 0.816 |
PKCZ |
0.846 | 0.115 | 2 | 0.760 |
PKCH |
0.846 | 0.124 | 2 | 0.711 |
CAMK1G |
0.846 | 0.161 | -3 | 0.833 |
CDK7 |
0.846 | 0.028 | 1 | 0.651 |
GRK6 |
0.845 | -0.089 | 1 | 0.811 |
IRE2 |
0.845 | 0.014 | 2 | 0.724 |
BMPR1B |
0.845 | 0.074 | 1 | 0.782 |
IKKA |
0.845 | -0.102 | -2 | 0.764 |
CDK8 |
0.844 | 0.003 | 1 | 0.647 |
MARK3 |
0.844 | 0.115 | 4 | 0.842 |
MLK3 |
0.844 | 0.009 | 2 | 0.734 |
DLK |
0.844 | -0.154 | 1 | 0.811 |
ULK1 |
0.844 | -0.220 | -3 | 0.830 |
HIPK2 |
0.843 | 0.143 | 1 | 0.588 |
NEK2 |
0.843 | 0.027 | 2 | 0.796 |
CDK5 |
0.843 | 0.073 | 1 | 0.670 |
CLK2 |
0.843 | 0.209 | -3 | 0.822 |
PRKX |
0.843 | 0.201 | -3 | 0.746 |
P38A |
0.842 | 0.074 | 1 | 0.681 |
CDK18 |
0.842 | 0.074 | 1 | 0.578 |
WNK4 |
0.841 | 0.083 | -2 | 0.864 |
MARK2 |
0.841 | 0.092 | 4 | 0.813 |
CDK19 |
0.841 | 0.017 | 1 | 0.608 |
AURA |
0.841 | 0.131 | -2 | 0.685 |
DYRK1A |
0.841 | 0.141 | 1 | 0.705 |
AKT1 |
0.841 | 0.219 | -3 | 0.785 |
HIPK3 |
0.841 | 0.145 | 1 | 0.687 |
ATM |
0.841 | -0.055 | 1 | 0.740 |
BRSK2 |
0.840 | 0.026 | -3 | 0.863 |
ALK4 |
0.840 | -0.048 | -2 | 0.820 |
TGFBR1 |
0.840 | -0.004 | -2 | 0.789 |
PAK2 |
0.840 | 0.049 | -2 | 0.814 |
BRSK1 |
0.840 | 0.048 | -3 | 0.848 |
JNK2 |
0.839 | 0.063 | 1 | 0.589 |
PLK1 |
0.839 | -0.089 | -2 | 0.813 |
DCAMKL1 |
0.839 | 0.116 | -3 | 0.836 |
MEK1 |
0.839 | -0.135 | 2 | 0.779 |
SSTK |
0.839 | 0.130 | 4 | 0.873 |
VRK2 |
0.839 | -0.124 | 1 | 0.845 |
PKCI |
0.838 | 0.171 | 2 | 0.745 |
YSK4 |
0.838 | -0.072 | 1 | 0.768 |
PKACA |
0.838 | 0.190 | -2 | 0.667 |
PHKG2 |
0.838 | 0.109 | -3 | 0.847 |
DNAPK |
0.838 | 0.015 | 1 | 0.692 |
TTBK2 |
0.837 | -0.200 | 2 | 0.661 |
MARK1 |
0.837 | 0.070 | 4 | 0.858 |
P38B |
0.837 | 0.068 | 1 | 0.602 |
CDK13 |
0.837 | 0.002 | 1 | 0.619 |
MST3 |
0.837 | 0.129 | 2 | 0.834 |
PKCT |
0.837 | 0.137 | 2 | 0.711 |
SMMLCK |
0.837 | 0.142 | -3 | 0.881 |
CDK14 |
0.836 | 0.097 | 1 | 0.624 |
GRK4 |
0.836 | -0.204 | -2 | 0.829 |
ERK1 |
0.836 | 0.043 | 1 | 0.598 |
P70S6K |
0.836 | 0.131 | -3 | 0.792 |
SMG1 |
0.836 | -0.059 | 1 | 0.756 |
MAPKAPK5 |
0.836 | 0.036 | -3 | 0.807 |
DYRK3 |
0.836 | 0.164 | 1 | 0.695 |
PKCE |
0.836 | 0.198 | 2 | 0.725 |
MPSK1 |
0.836 | 0.166 | 1 | 0.819 |
CDK1 |
0.835 | 0.025 | 1 | 0.603 |
MLK4 |
0.835 | -0.062 | 2 | 0.705 |
CDK10 |
0.835 | 0.123 | 1 | 0.612 |
PKN1 |
0.834 | 0.205 | -3 | 0.804 |
CDK9 |
0.834 | 0.010 | 1 | 0.625 |
SNRK |
0.834 | -0.093 | 2 | 0.621 |
CAMK1D |
0.834 | 0.182 | -3 | 0.757 |
JNK3 |
0.834 | 0.017 | 1 | 0.624 |
DRAK1 |
0.833 | -0.015 | 1 | 0.768 |
IRAK4 |
0.833 | 0.007 | 1 | 0.791 |
DYRK4 |
0.833 | 0.093 | 1 | 0.596 |
ACVR2A |
0.833 | -0.033 | -2 | 0.788 |
CHAK1 |
0.832 | -0.123 | 2 | 0.730 |
PERK |
0.832 | -0.067 | -2 | 0.835 |
ACVR2B |
0.832 | -0.041 | -2 | 0.797 |
BUB1 |
0.832 | 0.300 | -5 | 0.866 |
HRI |
0.832 | -0.102 | -2 | 0.845 |
CDK12 |
0.831 | 0.012 | 1 | 0.591 |
DYRK1B |
0.831 | 0.090 | 1 | 0.630 |
AKT3 |
0.831 | 0.223 | -3 | 0.717 |
ALK2 |
0.831 | -0.039 | -2 | 0.798 |
P38G |
0.831 | 0.031 | 1 | 0.514 |
DCAMKL2 |
0.831 | 0.054 | -3 | 0.857 |
ERK2 |
0.831 | -0.004 | 1 | 0.636 |
CHK2 |
0.831 | 0.211 | -3 | 0.721 |
GRK7 |
0.831 | -0.031 | 1 | 0.733 |
CDK17 |
0.831 | 0.023 | 1 | 0.520 |
CDK2 |
0.830 | -0.016 | 1 | 0.681 |
TLK2 |
0.830 | -0.115 | 1 | 0.805 |
MAK |
0.829 | 0.231 | -2 | 0.777 |
PLK4 |
0.829 | -0.102 | 2 | 0.568 |
NEK5 |
0.829 | -0.028 | 1 | 0.827 |
MEK5 |
0.828 | -0.178 | 2 | 0.774 |
MRCKB |
0.828 | 0.210 | -3 | 0.807 |
DAPK3 |
0.828 | 0.163 | -3 | 0.855 |
CDK16 |
0.828 | 0.070 | 1 | 0.539 |
ERK7 |
0.828 | 0.137 | 2 | 0.608 |
GAK |
0.827 | 0.144 | 1 | 0.858 |
PASK |
0.827 | 0.061 | -3 | 0.895 |
PAK5 |
0.827 | 0.093 | -2 | 0.703 |
PRP4 |
0.827 | 0.013 | -3 | 0.778 |
PLK3 |
0.827 | -0.140 | 2 | 0.716 |
CAMK1A |
0.827 | 0.216 | -3 | 0.733 |
SGK1 |
0.826 | 0.200 | -3 | 0.704 |
BRAF |
0.826 | -0.118 | -4 | 0.822 |
ROCK2 |
0.826 | 0.216 | -3 | 0.846 |
P38D |
0.826 | 0.056 | 1 | 0.540 |
CDK3 |
0.826 | 0.044 | 1 | 0.542 |
MEKK1 |
0.826 | -0.141 | 1 | 0.800 |
PINK1 |
0.825 | -0.145 | 1 | 0.835 |
MEKK3 |
0.825 | -0.168 | 1 | 0.789 |
MEKK2 |
0.825 | -0.100 | 2 | 0.757 |
MOK |
0.825 | 0.209 | 1 | 0.712 |
BMPR1A |
0.824 | 0.010 | 1 | 0.758 |
GRK2 |
0.824 | -0.087 | -2 | 0.727 |
PAK4 |
0.824 | 0.092 | -2 | 0.710 |
ZAK |
0.824 | -0.144 | 1 | 0.765 |
TLK1 |
0.823 | -0.134 | -2 | 0.812 |
TAO3 |
0.823 | -0.033 | 1 | 0.780 |
MRCKA |
0.823 | 0.170 | -3 | 0.820 |
MEKK6 |
0.822 | 0.044 | 1 | 0.784 |
NEK8 |
0.821 | -0.066 | 2 | 0.795 |
DAPK1 |
0.821 | 0.145 | -3 | 0.844 |
PDK1 |
0.821 | 0.010 | 1 | 0.798 |
LKB1 |
0.821 | -0.018 | -3 | 0.847 |
SBK |
0.821 | 0.198 | -3 | 0.666 |
CK1E |
0.821 | -0.050 | -3 | 0.527 |
NEK4 |
0.820 | 0.005 | 1 | 0.789 |
TAO2 |
0.820 | -0.023 | 2 | 0.822 |
DMPK1 |
0.820 | 0.234 | -3 | 0.823 |
NEK11 |
0.820 | -0.106 | 1 | 0.789 |
CAMKK1 |
0.820 | -0.119 | -2 | 0.785 |
IRAK1 |
0.820 | -0.176 | -1 | 0.742 |
MINK |
0.820 | 0.065 | 1 | 0.800 |
GCK |
0.820 | 0.052 | 1 | 0.810 |
HGK |
0.819 | 0.054 | 3 | 0.887 |
HPK1 |
0.819 | 0.096 | 1 | 0.791 |
TNIK |
0.819 | 0.084 | 3 | 0.892 |
CAMKK2 |
0.819 | -0.069 | -2 | 0.786 |
LOK |
0.818 | 0.057 | -2 | 0.798 |
LRRK2 |
0.817 | -0.005 | 2 | 0.823 |
NEK1 |
0.816 | 0.052 | 1 | 0.792 |
TAK1 |
0.816 | 0.005 | 1 | 0.840 |
GSK3B |
0.816 | -0.038 | 4 | 0.412 |
PBK |
0.815 | 0.137 | 1 | 0.797 |
TTBK1 |
0.815 | -0.183 | 2 | 0.584 |
CDK6 |
0.815 | 0.038 | 1 | 0.606 |
KHS2 |
0.815 | 0.133 | 1 | 0.800 |
MAP3K15 |
0.815 | -0.040 | 1 | 0.751 |
KHS1 |
0.814 | 0.100 | 1 | 0.786 |
EEF2K |
0.814 | 0.000 | 3 | 0.851 |
CDK4 |
0.814 | 0.036 | 1 | 0.578 |
MST2 |
0.813 | -0.068 | 1 | 0.802 |
PKG1 |
0.813 | 0.133 | -2 | 0.640 |
ROCK1 |
0.813 | 0.195 | -3 | 0.819 |
CK1D |
0.812 | -0.047 | -3 | 0.475 |
CRIK |
0.812 | 0.197 | -3 | 0.788 |
CK1A2 |
0.811 | -0.044 | -3 | 0.478 |
GSK3A |
0.810 | -0.030 | 4 | 0.421 |
JNK1 |
0.810 | -0.012 | 1 | 0.575 |
CK1G1 |
0.810 | -0.086 | -3 | 0.517 |
YSK1 |
0.810 | 0.034 | 2 | 0.799 |
VRK1 |
0.809 | -0.112 | 2 | 0.793 |
CK2A2 |
0.808 | -0.002 | 1 | 0.713 |
GRK3 |
0.808 | -0.093 | -2 | 0.683 |
SLK |
0.808 | -0.031 | -2 | 0.749 |
MST1 |
0.808 | -0.060 | 1 | 0.787 |
STK33 |
0.804 | -0.155 | 2 | 0.567 |
NEK3 |
0.804 | -0.039 | 1 | 0.752 |
PDHK3_TYR |
0.804 | 0.145 | 4 | 0.909 |
BIKE |
0.803 | 0.149 | 1 | 0.757 |
RIPK2 |
0.802 | -0.223 | 1 | 0.729 |
MEK2 |
0.801 | -0.223 | 2 | 0.745 |
MYO3B |
0.799 | 0.058 | 2 | 0.810 |
PLK2 |
0.797 | -0.110 | -3 | 0.776 |
CK2A1 |
0.797 | -0.023 | 1 | 0.691 |
HASPIN |
0.797 | 0.011 | -1 | 0.705 |
LIMK2_TYR |
0.796 | 0.115 | -3 | 0.912 |
TESK1_TYR |
0.796 | -0.023 | 3 | 0.908 |
TTK |
0.795 | -0.036 | -2 | 0.820 |
PKMYT1_TYR |
0.795 | 0.028 | 3 | 0.878 |
MAP2K4_TYR |
0.794 | -0.040 | -1 | 0.852 |
MYO3A |
0.791 | -0.022 | 1 | 0.775 |
AAK1 |
0.791 | 0.191 | 1 | 0.662 |
MAP2K7_TYR |
0.790 | -0.199 | 2 | 0.810 |
PDHK4_TYR |
0.790 | -0.070 | 2 | 0.825 |
MAP2K6_TYR |
0.790 | -0.101 | -1 | 0.851 |
OSR1 |
0.789 | -0.124 | 2 | 0.758 |
BMPR2_TYR |
0.789 | -0.041 | -1 | 0.850 |
TAO1 |
0.789 | -0.051 | 1 | 0.715 |
EPHA6 |
0.789 | 0.026 | -1 | 0.842 |
ASK1 |
0.788 | -0.148 | 1 | 0.734 |
PINK1_TYR |
0.788 | -0.143 | 1 | 0.815 |
LIMK1_TYR |
0.786 | -0.084 | 2 | 0.811 |
PDHK1_TYR |
0.785 | -0.156 | -1 | 0.861 |
YANK3 |
0.784 | -0.092 | 2 | 0.372 |
MST1R |
0.782 | -0.097 | 3 | 0.838 |
RET |
0.782 | -0.120 | 1 | 0.778 |
EPHB4 |
0.781 | -0.050 | -1 | 0.814 |
ROS1 |
0.781 | -0.081 | 3 | 0.810 |
TYK2 |
0.780 | -0.142 | 1 | 0.781 |
TYRO3 |
0.780 | -0.117 | 3 | 0.829 |
ABL2 |
0.780 | -0.020 | -1 | 0.786 |
DDR1 |
0.779 | -0.124 | 4 | 0.842 |
JAK2 |
0.779 | -0.119 | 1 | 0.774 |
TNNI3K_TYR |
0.779 | 0.080 | 1 | 0.789 |
TNK2 |
0.778 | -0.008 | 3 | 0.784 |
TXK |
0.778 | 0.037 | 1 | 0.815 |
ABL1 |
0.777 | -0.024 | -1 | 0.782 |
ALPHAK3 |
0.776 | -0.175 | -1 | 0.745 |
LCK |
0.776 | 0.031 | -1 | 0.817 |
FGR |
0.775 | -0.096 | 1 | 0.838 |
HCK |
0.775 | -0.048 | -1 | 0.812 |
CSF1R |
0.774 | -0.146 | 3 | 0.811 |
YES1 |
0.774 | -0.075 | -1 | 0.823 |
TNK1 |
0.773 | -0.035 | 3 | 0.813 |
ITK |
0.773 | -0.059 | -1 | 0.782 |
BLK |
0.773 | 0.034 | -1 | 0.819 |
JAK1 |
0.773 | -0.007 | 1 | 0.728 |
FER |
0.772 | -0.173 | 1 | 0.834 |
NEK10_TYR |
0.772 | -0.074 | 1 | 0.683 |
EPHA4 |
0.772 | -0.091 | 2 | 0.728 |
JAK3 |
0.771 | -0.164 | 1 | 0.761 |
INSRR |
0.770 | -0.150 | 3 | 0.785 |
CK1A |
0.770 | -0.096 | -3 | 0.380 |
SRMS |
0.770 | -0.119 | 1 | 0.814 |
EPHB1 |
0.769 | -0.120 | 1 | 0.804 |
EPHB3 |
0.768 | -0.114 | -1 | 0.800 |
STLK3 |
0.768 | -0.273 | 1 | 0.729 |
EPHB2 |
0.768 | -0.097 | -1 | 0.795 |
PDGFRB |
0.767 | -0.195 | 3 | 0.822 |
FLT3 |
0.766 | -0.171 | 3 | 0.817 |
WEE1_TYR |
0.766 | -0.077 | -1 | 0.732 |
AXL |
0.766 | -0.136 | 3 | 0.801 |
MERTK |
0.766 | -0.109 | 3 | 0.801 |
KDR |
0.766 | -0.140 | 3 | 0.773 |
BMX |
0.766 | -0.067 | -1 | 0.707 |
FGFR2 |
0.765 | -0.222 | 3 | 0.823 |
TEC |
0.765 | -0.079 | -1 | 0.733 |
TEK |
0.763 | -0.199 | 3 | 0.768 |
BTK |
0.763 | -0.180 | -1 | 0.748 |
KIT |
0.763 | -0.217 | 3 | 0.806 |
PDGFRA |
0.762 | -0.224 | 3 | 0.821 |
FYN |
0.761 | -0.031 | -1 | 0.797 |
ALK |
0.761 | -0.167 | 3 | 0.745 |
DDR2 |
0.760 | -0.047 | 3 | 0.764 |
FGFR1 |
0.760 | -0.242 | 3 | 0.789 |
EPHA7 |
0.759 | -0.123 | 2 | 0.727 |
PTK2B |
0.759 | -0.055 | -1 | 0.775 |
LTK |
0.759 | -0.167 | 3 | 0.759 |
EPHA1 |
0.759 | -0.121 | 3 | 0.787 |
MET |
0.758 | -0.191 | 3 | 0.811 |
LYN |
0.758 | -0.106 | 3 | 0.734 |
EPHA3 |
0.757 | -0.175 | 2 | 0.697 |
FRK |
0.756 | -0.145 | -1 | 0.822 |
PTK6 |
0.756 | -0.259 | -1 | 0.708 |
INSR |
0.754 | -0.203 | 3 | 0.770 |
FLT1 |
0.753 | -0.210 | -1 | 0.795 |
NTRK1 |
0.753 | -0.291 | -1 | 0.781 |
ERBB2 |
0.753 | -0.242 | 1 | 0.732 |
NTRK2 |
0.751 | -0.272 | 3 | 0.774 |
FLT4 |
0.750 | -0.262 | 3 | 0.768 |
SRC |
0.750 | -0.114 | -1 | 0.791 |
FGFR3 |
0.750 | -0.263 | 3 | 0.793 |
EPHA5 |
0.750 | -0.155 | 2 | 0.704 |
PTK2 |
0.749 | -0.042 | -1 | 0.768 |
YANK2 |
0.748 | -0.133 | 2 | 0.383 |
NTRK3 |
0.747 | -0.234 | -1 | 0.733 |
MATK |
0.746 | -0.205 | -1 | 0.706 |
EPHA8 |
0.746 | -0.172 | -1 | 0.780 |
CK1G3 |
0.745 | -0.113 | -3 | 0.331 |
CSK |
0.743 | -0.232 | 2 | 0.726 |
EGFR |
0.742 | -0.184 | 1 | 0.633 |
MUSK |
0.741 | -0.176 | 1 | 0.631 |
SYK |
0.738 | -0.105 | -1 | 0.743 |
FGFR4 |
0.738 | -0.216 | -1 | 0.734 |
EPHA2 |
0.737 | -0.170 | -1 | 0.742 |
IGF1R |
0.736 | -0.224 | 3 | 0.709 |
ERBB4 |
0.731 | -0.151 | 1 | 0.655 |
FES |
0.725 | -0.204 | -1 | 0.687 |
CK1G2 |
0.725 | -0.124 | -3 | 0.429 |
ZAP70 |
0.715 | -0.140 | -1 | 0.674 |