Motif 30 (n=182)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S519 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A4D1P6 | WDR91 | S256 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
| A6H8Y1 | BDP1 | S1781 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| B0I1T2 | MYO1G | S695 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| O00442 | RTCA | S173 | ochoa | RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1) | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed:9184239). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed:9184239). Likely functions in some aspects of cellular RNA processing (PubMed:25961792, PubMed:9184239). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792). {ECO:0000269|PubMed:25961792, ECO:0000269|PubMed:9184239}. |
| O14526 | FCHO1 | S616 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14920 | IKBKB | S550 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15403 | SLC16A6 | S247 | ochoa | Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) | Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations. {ECO:0000250|UniProtKB:Q7TMR7}. |
| O43491 | EPB41L2 | S499 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43896 | KIF1C | S494 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60216 | RAD21 | S46 | ochoa | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
| O60318 | MCM3AP | S1926 | ochoa | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) | [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}. |
| O60333 | KIF1B | S527 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60353 | FZD6 | S653 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
| O60568 | PLOD3 | S702 | ochoa | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] | Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812, PubMed:9582318, PubMed:9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity). {ECO:0000250|UniProtKB:Q9R0E1, ECO:0000269|PubMed:10934207, ECO:0000269|PubMed:11896059, ECO:0000269|PubMed:11956192, ECO:0000269|PubMed:12475640, ECO:0000269|PubMed:18298658, ECO:0000269|PubMed:18834968, ECO:0000269|PubMed:25419660, ECO:0000269|PubMed:30089812, ECO:0000269|PubMed:9582318, ECO:0000269|PubMed:9724729, ECO:0000305}. |
| O75467 | ZNF324 | S164 | ochoa | Zinc finger protein 324A (Zinc finger protein ZF5128) | May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. {ECO:0000305|PubMed:11779640}. |
| O75899 | GABBR2 | S884 | ochoa | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). {ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:15617512, ECO:0000269|PubMed:18165688, ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054, ECO:0000269|PubMed:9872316, ECO:0000269|PubMed:9872744, ECO:0000305}. |
| O94913 | PCF11 | S1493 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94979 | SEC31A | S188 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95155 | UBE4B | S1265 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95235 | KIF20A | S21 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95382 | MAP3K6 | S984 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95400 | CD2BP2 | S195 | ochoa | CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K) | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269|PubMed:15840814}. |
| O95402 | MED26 | S470 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| P04350 | TUBB4A | S172 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05162 | LGALS2 | S77 | ochoa | Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2) | This protein binds beta-galactoside. Its physiological function is not yet known. |
| P07437 | TUBB | S172 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08151 | GLI1 | S201 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P08697 | SERPINF2 | S450 | ochoa | Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) | Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}. |
| P15822 | HIVEP1 | S130 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P15822 | HIVEP1 | S1051 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17028 | ZNF24 | S63 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P27694 | RPA1 | S38 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P28749 | RBL1 | S650 | ochoa|psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P29374 | ARID4A | S932 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P30304 | CDC25A | S88 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P31689 | DNAJA1 | S188 | ochoa | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}. |
| P35612 | ADD2 | S60 | ochoa | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P48556 | PSMD8 | S106 | ochoa | 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| P51531 | SMARCA2 | S172 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P53816 | PLAAT3 | S85 | ochoa | Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65) | Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760, PubMed:19615464, PubMed:22605381, PubMed:22825852). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity). {ECO:0000250|UniProtKB:Q8R3U1, ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:22923616, ECO:0000303|PubMed:26503625}.; FUNCTION: (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878). {ECO:0000269|PubMed:28077878}. |
| P53992 | SEC24C | S888 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P57737 | CORO7 | S775 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P68371 | TUBB4B | S172 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78312 | FAM193A | S666 | ochoa | Protein FAM193A (Protein IT14) | None |
| P81274 | GPSM2 | S541 | ochoa | G-protein-signaling modulator 2 (Mosaic protein LGN) | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22327364}. |
| Q01082 | SPTBN1 | S817 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q03060 | CREM | S271 | psp | cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}. |
| Q06710 | PAX8 | S251 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q07866 | KLC1 | S460 | ochoa|psp | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q12756 | KIF1A | S487 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q13075 | NAIP | S982 | ochoa | Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein) | Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; FUNCTION: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila. |
| Q13362 | PPP2R5C | S298 | psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
| Q13416 | ORC2 | S280 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13495 | MAMLD1 | S190 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13509 | TUBB3 | S172 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13523 | PRP4K | S93 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13813 | SPTAN1 | S1413 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13823 | GNL2 | S234 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q13885 | TUBB2A | S172 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14207 | NPAT | S1100 | ochoa|psp | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14966 | ZNF638 | S420 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14CB8 | ARHGAP19 | S470 | ochoa | Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q15058 | KIF14 | S20 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15475 | SIX1 | S150 | ochoa | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as a transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:15141091, PubMed:19497856, PubMed:23435380, PubMed:27923061). Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q62231, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141091, ECO:0000269|PubMed:19497856, ECO:0000269|PubMed:23435380, ECO:0000269|PubMed:27923061}. |
| Q15697 | ZNF174 | S287 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
| Q15738 | NSDHL | S106 | ochoa | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3) | Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity). {ECO:0000250|UniProtKB:Q9R1J0}. |
| Q15911 | ZFHX3 | S533 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q2LD37 | BLTP1 | S2287 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2M1Z3 | ARHGAP31 | S629 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2M2I8 | AAK1 | S797 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q587J7 | TDRD12 | S211 | ochoa | Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) | Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. {ECO:0000250|UniProtKB:Q9CWU0}. |
| Q5I0X7 | TTC32 | S47 | ochoa | Tetratricopeptide repeat protein 32 (TPR repeat protein 32) | None |
| Q5JTH9 | RRP12 | S801 | ochoa | RRP12-like protein | None |
| Q5SVQ8 | ZBTB41 | S57 | ochoa | Zinc finger and BTB domain-containing protein 41 | May be involved in transcriptional regulation. |
| Q5T6F2 | UBAP2 | S473 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
| Q5T8P6 | RBM26 | S616 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5UIP0 | RIF1 | S2348 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VUA4 | ZNF318 | S237 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5W0B1 | OBI1 | S416 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6IQ26 | DENND5A | S455 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6P4E1 | GOLM2 | S366 | ochoa | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | None |
| Q6P995 | FAM171B | S794 | ochoa | Protein FAM171B | None |
| Q6UB98 | ANKRD12 | S526 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB98 | ANKRD12 | S630 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6ZS17 | RIPOR1 | S171 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZS81 | WDFY4 | S1688 | ochoa | WD repeat- and FYVE domain-containing protein 4 | Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. {ECO:0000250|UniProtKB:E9Q2M9}. |
| Q6ZUM4 | ARHGAP27 | S466 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71SY5 | MED25 | S184 | ochoa | Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}. |
| Q76FK4 | NOL8 | S268 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L590 | MCM10 | S644 | ochoa | Protein MCM10 homolog (HsMCM10) | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}. |
| Q7Z3K3 | POGZ | S554 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z4V5 | HDGFL2 | S490 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z628 | NET1 | S508 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6Z7 | HUWE1 | S2508 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7G8 | VPS13B | S414 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86TJ2 | TADA2B | S144 | ochoa | Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta) | Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}. |
| Q86VI3 | IQGAP3 | S539 | ochoa | Ras GTPase-activating-like protein IQGAP3 | None |
| Q86XK2 | FBXO11 | S97 | ochoa | F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:33156908, ECO:0000269|PubMed:36897010, ECO:0000269|PubMed:37279268}. |
| Q8IWZ8 | SUGP1 | S411 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IYD8 | FANCM | S997 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IYX8 | CEP57L1 | S49 | ochoa | Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein) | Centrosomal protein which may be required for microtubule attachment to centrosomes. {ECO:0000250}. |
| Q8N0Z3 | SPICE1 | S640 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N5I9 | NOPCHAP1 | S66 | ochoa | NOP protein chaperone 1 | Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. {ECO:0000269|PubMed:33367824}. |
| Q8ND04 | SMG8 | S469 | ochoa | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
| Q8NG08 | HELB | S1058 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8TD43 | TRPM4 | S1152 | psp | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}. |
| Q8TEH3 | DENND1A | S473 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TEV9 | SMCR8 | S790 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WWQ0 | PHIP | S1377 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WXH0 | SYNE2 | S4025 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q96AE7 | TTC17 | S56 | ochoa | Tetratricopeptide repeat protein 17 (TPR repeat protein 17) | Plays a role in primary ciliogenesis by modulating actin polymerization. {ECO:0000269|PubMed:24475127}. |
| Q96ES7 | SGF29 | S52 | ochoa | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}. |
| Q96H22 | CENPN | S299 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96L93 | KIF16B | S398 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96PZ2 | FAM111A | S62 | ochoa | Serine protease FAM111A (EC 3.4.21.-) | Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:32165630, ECO:0000269|PubMed:37607234}. |
| Q96Q11 | TRNT1 | S289 | ochoa | CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase) | Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:11504732, PubMed:25193871, PubMed:25640237, PubMed:25652405, PubMed:29454993, PubMed:30959222, PubMed:31011209, PubMed:34023389). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (PubMed:22076379, PubMed:25640237). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1 (PubMed:31011209). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (PubMed:22076379, PubMed:25640237). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (PubMed:22076379, PubMed:25640237). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (PubMed:25640237). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (PubMed:25640237). {ECO:0000269|PubMed:11504732, ECO:0000269|PubMed:22076379, ECO:0000269|PubMed:25193871, ECO:0000269|PubMed:25640237, ECO:0000269|PubMed:25652405, ECO:0000269|PubMed:29454993, ECO:0000269|PubMed:30959222, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:34023389}.; FUNCTION: [Isoform 2]: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro). {ECO:0000269|PubMed:17204286}. |
| Q96QD9 | FYTTD1 | S118 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q96QT4 | TRPM7 | S1543 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96ST2 | IWS1 | S621 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96T58 | SPEN | S1918 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99708 | RBBP8 | S568 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99933 | BAG1 | S223 | ochoa | BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:24318877, PubMed:27474739, PubMed:9873016). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). {ECO:0000250|UniProtKB:B0K019, ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}. |
| Q9BQA1 | WDR77 | S264 | psp | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. |
| Q9BRX2 | PELO | S58 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BUF5 | TUBB6 | S172 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S172 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWF2 | TRAIP | S295 | ochoa | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:31545170}. |
| Q9C0D5 | TANC1 | S132 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZR7 | DDX24 | S60 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H078 | CLPB | S668 | ochoa | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). {ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:32573439, ECO:0000269|PubMed:34115842, ECO:0000269|PubMed:35247700, ECO:0000269|PubMed:36170828, ECO:0000269|PubMed:36745679}. |
| Q9H0B6 | KLC2 | S445 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H0G5 | NSRP1 | S457 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H211 | CDT1 | S372 | psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H400 | LIME1 | S61 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H4A4 | RNPEP | S528 | ochoa | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| Q9H4L5 | OSBPL3 | S410 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9HCE0 | EPG5 | S1393 | ochoa | Ectopic P granules protein 5 homolog | Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391). {ECO:0000269|PubMed:20550938, ECO:0000269|PubMed:23222957, ECO:0000269|PubMed:29130391}. |
| Q9HCH5 | SYTL2 | S437 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NPC8 | SIX2 | S150 | ochoa | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}. |
| Q9NPI1 | BRD7 | S621 | ochoa | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q9NPI6 | DCP1A | S353 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NR09 | BIRC6 | S620 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR48 | ASH1L | S1170 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRY4 | ARHGAP35 | S975 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NSI6 | BRWD1 | S1374 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NSK0 | KLC4 | S460 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NVG8 | TBC1D13 | S184 | ochoa | TBC1 domain family member 13 | Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. {ECO:0000250|UniProtKB:Q8R3D1}. |
| Q9NWA0 | MED9 | S80 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9NYQ8 | FAT2 | S4258 | ochoa | Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) | Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). {ECO:0000250|UniProtKB:O88277, ECO:0000269|PubMed:18534823}. |
| Q9NZB2 | FAM120A | S652 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P0Z9 | PIPOX | S299 | ochoa | Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) | Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}. |
| Q9P219 | CCDC88C | S1825 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P227 | ARHGAP23 | S843 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2K3 | RCOR3 | S33 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9UEY8 | ADD3 | S64 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UH62 | ARMCX3 | S119 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UH62 | ARMCX3 | S218 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHD1 | CHORDC1 | S110 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| Q9UHF7 | TRPS1 | S978 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UHI6 | DDX20 | S48 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UHI6 | DDX20 | S187 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UIA9 | XPO7 | S40 | ochoa | Exportin-7 (Exp7) (Ran-binding protein 16) | Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:11024021, ECO:0000269|PubMed:15282546}. |
| Q9UKA4 | AKAP11 | S1013 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKD1 | GMEB2 | S126 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UKL0 | RCOR1 | S139 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKZ1 | CNOT11 | S340 | ochoa | CCR4-NOT transcription complex subunit 11 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. |
| Q9ULU4 | ZMYND8 | S406 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULV3 | CIZ1 | S783 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UM63 | PLAGL1 | S341 | ochoa | Zinc finger protein PLAGL1 (Lost on transformation 1) (LOT-1) (Pleiomorphic adenoma-like protein 1) (Tumor suppressor ZAC) | Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. {ECO:0000269|PubMed:18299245, ECO:0000269|PubMed:9722527}. |
| Q9UQ80 | PA2G4 | S90 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y573 | IPP | S265 | ochoa | Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Kelch-like protein 27) | May play a role in organizing the actin cytoskeleton. |
| Q9Y5W7 | SNX14 | S734 | ochoa | Sorting nexin-14 | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684, PubMed:25848753). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}. |
| Q9Y692 | GMEB1 | S129 | ochoa | Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| O00444 | PLK4 | S592 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| Q92973 | TNPO1 | S111 | Sugiyama | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q9BQQ3 | GORASP1 | S373 | SIGNOR | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| P22612 | PRKACG | S40 | Sugiyama | cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. |
| Q02641 | CACNB1 | S161 | SIGNOR | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| P17936 | IGFBP3 | S97 | Sugiyama | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| Q5S007 | LRRK2 | S1124 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| P49005 | POLD2 | S75 | Sugiyama | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-983189 | Kinesins | 7.771561e-16 | 15.109 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.720491e-13 | 12.112 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.628886e-11 | 10.179 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.907397e-11 | 10.050 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.801998e-09 | 8.553 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.073113e-09 | 8.217 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.611438e-08 | 7.793 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.176742e-08 | 7.662 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.188027e-08 | 7.660 |
| R-HSA-1640170 | Cell Cycle | 3.711773e-08 | 7.430 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.993166e-07 | 6.524 |
| R-HSA-199991 | Membrane Trafficking | 3.148464e-07 | 6.502 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 7.422596e-07 | 6.129 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 8.918372e-07 | 6.050 |
| R-HSA-190861 | Gap junction assembly | 1.031632e-06 | 5.986 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.198329e-06 | 5.921 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.384659e-06 | 5.859 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.657367e-06 | 5.781 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.085335e-06 | 5.681 |
| R-HSA-9833482 | PKR-mediated signaling | 2.001886e-06 | 5.699 |
| R-HSA-69275 | G2/M Transition | 2.235635e-06 | 5.651 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.529606e-06 | 5.597 |
| R-HSA-9646399 | Aggrephagy | 2.520802e-06 | 5.598 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.482345e-06 | 5.605 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.352808e-06 | 5.475 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.304985e-06 | 5.481 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.370709e-06 | 5.359 |
| R-HSA-190828 | Gap junction trafficking | 4.855565e-06 | 5.314 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.077017e-06 | 5.216 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.969152e-06 | 5.157 |
| R-HSA-437239 | Recycling pathway of L1 | 6.969152e-06 | 5.157 |
| R-HSA-5620924 | Intraflagellar transport | 7.824082e-06 | 5.107 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.285532e-06 | 5.082 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 9.084773e-06 | 5.042 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.764314e-06 | 5.057 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.494315e-05 | 4.826 |
| R-HSA-68877 | Mitotic Prometaphase | 1.691617e-05 | 4.772 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.659016e-05 | 4.780 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.730640e-05 | 4.762 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.113628e-05 | 4.675 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.478410e-05 | 4.606 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.529463e-05 | 4.597 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.922345e-05 | 4.534 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.191500e-05 | 4.496 |
| R-HSA-373760 | L1CAM interactions | 4.297443e-05 | 4.367 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.669137e-05 | 4.331 |
| R-HSA-68882 | Mitotic Anaphase | 4.735612e-05 | 4.325 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.928949e-05 | 4.307 |
| R-HSA-68886 | M Phase | 5.189778e-05 | 4.285 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.848988e-05 | 4.164 |
| R-HSA-69206 | G1/S Transition | 7.532252e-05 | 4.123 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.991246e-05 | 4.097 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 9.838967e-05 | 4.007 |
| R-HSA-9663891 | Selective autophagy | 2.390984e-04 | 3.621 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.949123e-04 | 3.530 |
| R-HSA-5617833 | Cilium Assembly | 3.270007e-04 | 3.485 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.425810e-04 | 3.465 |
| R-HSA-9830369 | Kidney development | 3.896991e-04 | 3.409 |
| R-HSA-9830674 | Formation of the ureteric bud | 5.137798e-04 | 3.289 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.140640e-03 | 2.943 |
| R-HSA-69242 | S Phase | 1.226109e-03 | 2.911 |
| R-HSA-1538133 | G0 and Early G1 | 1.389094e-03 | 2.857 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.384451e-03 | 2.859 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.526467e-03 | 2.816 |
| R-HSA-391251 | Protein folding | 1.874293e-03 | 2.727 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.170935e-03 | 2.663 |
| R-HSA-109582 | Hemostasis | 2.658978e-03 | 2.575 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.694207e-03 | 2.570 |
| R-HSA-1632852 | Macroautophagy | 3.879339e-03 | 2.411 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 4.600991e-03 | 2.337 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 5.351493e-03 | 2.272 |
| R-HSA-9612973 | Autophagy | 6.469414e-03 | 2.189 |
| R-HSA-4839726 | Chromatin organization | 6.930451e-03 | 2.159 |
| R-HSA-69481 | G2/M Checkpoints | 9.115598e-03 | 2.040 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 9.189754e-03 | 2.037 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.951820e-03 | 2.002 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.065387e-02 | 1.972 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.166656e-02 | 1.933 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.127198e-02 | 1.948 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.235888e-02 | 1.908 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.235888e-02 | 1.908 |
| R-HSA-1280218 | Adaptive Immune System | 1.386832e-02 | 1.858 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.417569e-02 | 1.848 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.480922e-02 | 1.829 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.528331e-02 | 1.816 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.826550e-02 | 1.738 |
| R-HSA-69239 | Synthesis of DNA | 1.713613e-02 | 1.766 |
| R-HSA-9609690 | HCMV Early Events | 1.874110e-02 | 1.727 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.904825e-02 | 1.720 |
| R-HSA-380287 | Centrosome maturation | 2.060835e-02 | 1.686 |
| R-HSA-69306 | DNA Replication | 2.080089e-02 | 1.682 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.148201e-02 | 1.668 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.148201e-02 | 1.668 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.148201e-02 | 1.668 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.374338e-02 | 1.624 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.374338e-02 | 1.624 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.375792e-02 | 1.624 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.383564e-02 | 1.623 |
| R-HSA-422475 | Axon guidance | 2.544341e-02 | 1.594 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.858548e-02 | 1.544 |
| R-HSA-1500620 | Meiosis | 2.957015e-02 | 1.529 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.107557e-02 | 1.508 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.107557e-02 | 1.508 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.107557e-02 | 1.508 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.369375e-02 | 1.472 |
| R-HSA-5358508 | Mismatch Repair | 3.369375e-02 | 1.472 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.369375e-02 | 1.472 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 3.657786e-02 | 1.437 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.657786e-02 | 1.437 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 3.657786e-02 | 1.437 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.589779e-02 | 1.445 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.203609e-02 | 1.376 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.956175e-02 | 1.403 |
| R-HSA-373753 | Nephrin family interactions | 3.917642e-02 | 1.407 |
| R-HSA-9675108 | Nervous system development | 3.918648e-02 | 1.407 |
| R-HSA-112316 | Neuronal System | 4.312492e-02 | 1.365 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.497154e-02 | 1.347 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.546146e-02 | 1.342 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 4.847218e-02 | 1.315 |
| R-HSA-9609646 | HCMV Infection | 5.303398e-02 | 1.275 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 5.420988e-02 | 1.266 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 5.742600e-02 | 1.241 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 5.742600e-02 | 1.241 |
| R-HSA-1266695 | Interleukin-7 signaling | 5.742600e-02 | 1.241 |
| R-HSA-9830364 | Formation of the nephric duct | 5.742600e-02 | 1.241 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.752308e-02 | 1.240 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 6.405051e-02 | 1.193 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 7.091779e-02 | 1.149 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 7.091779e-02 | 1.149 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.419967e-02 | 1.130 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.771630e-02 | 1.169 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.022038e-02 | 1.220 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.405051e-02 | 1.193 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 6.070690e-02 | 1.217 |
| R-HSA-3295583 | TRP channels | 6.070690e-02 | 1.217 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.419967e-02 | 1.130 |
| R-HSA-9008059 | Interleukin-37 signaling | 7.443751e-02 | 1.128 |
| R-HSA-913531 | Interferon Signaling | 6.675935e-02 | 1.175 |
| R-HSA-5632684 | Hedgehog 'on' state | 7.642012e-02 | 1.117 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.866967e-02 | 1.104 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.866967e-02 | 1.104 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 8.094799e-02 | 1.092 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 9.460599e-02 | 1.024 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.057873e-01 | 0.976 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.168313e-01 | 0.932 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.385137e-01 | 0.859 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.491554e-01 | 0.826 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 1.596664e-01 | 0.797 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.596664e-01 | 0.797 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.596664e-01 | 0.797 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.596664e-01 | 0.797 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.700481e-01 | 0.769 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.803022e-01 | 0.744 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.803022e-01 | 0.744 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.803022e-01 | 0.744 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.803022e-01 | 0.744 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.803022e-01 | 0.744 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.803022e-01 | 0.744 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.904302e-01 | 0.720 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.103143e-01 | 0.677 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.200733e-01 | 0.657 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.200733e-01 | 0.657 |
| R-HSA-5696400 | Dual Incision in GG-NER | 9.282159e-02 | 1.032 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.297123e-01 | 0.639 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.579239e-01 | 0.589 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.670974e-01 | 0.573 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.670974e-01 | 0.573 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.670974e-01 | 0.573 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.670974e-01 | 0.573 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.670974e-01 | 0.573 |
| R-HSA-72187 | mRNA 3'-end processing | 1.714914e-01 | 0.766 |
| R-HSA-1221632 | Meiotic synapsis | 1.758984e-01 | 0.755 |
| R-HSA-1296059 | G protein gated Potassium channels | 3.198164e-01 | 0.495 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 3.198164e-01 | 0.495 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 3.198164e-01 | 0.495 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.198164e-01 | 0.495 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.892223e-01 | 0.723 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.257675e-01 | 0.487 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.257675e-01 | 0.487 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.412417e-01 | 0.850 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.412417e-01 | 0.850 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.761580e-01 | 0.559 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.030478e-01 | 0.518 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.204407e-01 | 0.919 |
| R-HSA-73893 | DNA Damage Bypass | 1.583893e-01 | 0.800 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.904302e-01 | 0.720 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.026781e-01 | 0.693 |
| R-HSA-191859 | snRNP Assembly | 2.026781e-01 | 0.693 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.103143e-01 | 0.677 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.670974e-01 | 0.573 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 1.412417e-01 | 0.850 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.579239e-01 | 0.589 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.851072e-01 | 0.545 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.939463e-01 | 0.532 |
| R-HSA-5693538 | Homology Directed Repair | 2.264942e-01 | 0.645 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.803022e-01 | 0.744 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.981799e-01 | 0.703 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.071784e-01 | 0.684 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.057873e-01 | 0.976 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.904302e-01 | 0.720 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.531817e-02 | 1.069 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.297123e-01 | 0.639 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 9.460599e-02 | 1.024 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.297123e-01 | 0.639 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.939463e-01 | 0.532 |
| R-HSA-912446 | Meiotic recombination | 1.671035e-01 | 0.777 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.204407e-01 | 0.919 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.761580e-01 | 0.559 |
| R-HSA-4791275 | Signaling by WNT in cancer | 8.163955e-02 | 1.088 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 9.282159e-02 | 1.032 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.221524e-01 | 0.492 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.200733e-01 | 0.657 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.376110e-01 | 0.861 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.527231e-01 | 0.597 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 9.460599e-02 | 1.024 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 9.460599e-02 | 1.024 |
| R-HSA-4839744 | Signaling by APC mutants | 1.596664e-01 | 0.797 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.700481e-01 | 0.769 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.700481e-01 | 0.769 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.700481e-01 | 0.769 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.904302e-01 | 0.720 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.103143e-01 | 0.677 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 9.282159e-02 | 1.032 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.392328e-01 | 0.621 |
| R-HSA-163615 | PKA activation | 2.486361e-01 | 0.604 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.486361e-01 | 0.604 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.245373e-01 | 0.905 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.939463e-01 | 0.532 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.112996e-01 | 0.507 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.117084e-01 | 0.674 |
| R-HSA-69190 | DNA strand elongation | 8.163955e-02 | 1.088 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.198164e-01 | 0.495 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.710424e-01 | 0.567 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.756221e-01 | 0.560 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.370207e-01 | 0.863 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.083651e-01 | 0.965 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.245373e-01 | 0.905 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.245373e-01 | 0.905 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.671035e-01 | 0.777 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.847649e-01 | 0.733 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.649864e-01 | 0.783 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.148793e-01 | 0.502 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.166995e-01 | 0.499 |
| R-HSA-73886 | Chromosome Maintenance | 2.362804e-01 | 0.627 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 9.460599e-02 | 1.024 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.700481e-01 | 0.769 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.103143e-01 | 0.677 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.297123e-01 | 0.639 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.579239e-01 | 0.589 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.207776e-01 | 0.656 |
| R-HSA-9843745 | Adipogenesis | 1.119978e-01 | 0.951 |
| R-HSA-180786 | Extension of Telomeres | 2.026781e-01 | 0.693 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 9.282159e-02 | 1.032 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.112996e-01 | 0.507 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 9.664291e-02 | 1.015 |
| R-HSA-1474165 | Reproduction | 1.099804e-01 | 0.959 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.527231e-01 | 0.597 |
| R-HSA-69109 | Leading Strand Synthesis | 1.803022e-01 | 0.744 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.803022e-01 | 0.744 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.803022e-01 | 0.744 |
| R-HSA-69091 | Polymerase switching | 1.803022e-01 | 0.744 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.004337e-01 | 0.698 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.200733e-01 | 0.657 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.200733e-01 | 0.657 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.579239e-01 | 0.589 |
| R-HSA-429947 | Deadenylation of mRNA | 3.112996e-01 | 0.507 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.325642e-01 | 0.878 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.103143e-01 | 0.677 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 9.664291e-02 | 1.015 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.412417e-01 | 0.850 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.596664e-01 | 0.797 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.004337e-01 | 0.698 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.026781e-01 | 0.693 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 3.257675e-01 | 0.487 |
| R-HSA-8848021 | Signaling by PTK6 | 2.207776e-01 | 0.656 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.207776e-01 | 0.656 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.297123e-01 | 0.639 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.486361e-01 | 0.604 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 2.939463e-01 | 0.532 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.626187e-01 | 0.789 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.519937e-01 | 0.818 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 9.460599e-02 | 1.024 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.103143e-01 | 0.677 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.392328e-01 | 0.621 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 2.670974e-01 | 0.573 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.198164e-01 | 0.495 |
| R-HSA-4086400 | PCP/CE pathway | 2.893500e-01 | 0.539 |
| R-HSA-8953854 | Metabolism of RNA | 1.801641e-01 | 0.744 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.198164e-01 | 0.495 |
| R-HSA-9659379 | Sensory processing of sound | 2.939201e-01 | 0.532 |
| R-HSA-9675135 | Diseases of DNA repair | 1.454904e-01 | 0.837 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.277395e-01 | 0.894 |
| R-HSA-392517 | Rap1 signalling | 2.579239e-01 | 0.589 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.245373e-01 | 0.905 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.435733e-01 | 0.613 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.232500e-01 | 0.651 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.436479e-01 | 0.613 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.204407e-01 | 0.919 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 3.198164e-01 | 0.495 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.892223e-01 | 0.723 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 8.531817e-02 | 1.069 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.803022e-01 | 0.744 |
| R-HSA-8963896 | HDL assembly | 2.004337e-01 | 0.698 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 8.904610e-02 | 1.050 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.486361e-01 | 0.604 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.117084e-01 | 0.674 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.385137e-01 | 0.859 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.071784e-01 | 0.684 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.579239e-01 | 0.589 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.112996e-01 | 0.507 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.710424e-01 | 0.567 |
| R-HSA-162582 | Signal Transduction | 1.999889e-01 | 0.699 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.818985e-01 | 0.740 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.123531e-01 | 0.949 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.325115e-02 | 1.080 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.112996e-01 | 0.507 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.212371e-01 | 0.493 |
| R-HSA-1266738 | Developmental Biology | 1.886641e-01 | 0.724 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.596664e-01 | 0.797 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.112996e-01 | 0.507 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.112996e-01 | 0.507 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.756221e-01 | 0.560 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.851630e-01 | 0.732 |
| R-HSA-9758941 | Gastrulation | 1.555920e-01 | 0.808 |
| R-HSA-9833110 | RSV-host interactions | 1.759287e-01 | 0.755 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.851630e-01 | 0.732 |
| R-HSA-9824446 | Viral Infection Pathways | 2.609256e-01 | 0.583 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.995901e-01 | 0.523 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.282284e-01 | 0.484 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.282284e-01 | 0.484 |
| R-HSA-70635 | Urea cycle | 3.282284e-01 | 0.484 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.282284e-01 | 0.484 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.302900e-01 | 0.481 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.302900e-01 | 0.481 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.365369e-01 | 0.473 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.365369e-01 | 0.473 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.365369e-01 | 0.473 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.365369e-01 | 0.473 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.365369e-01 | 0.473 |
| R-HSA-74160 | Gene expression (Transcription) | 3.423138e-01 | 0.466 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.438057e-01 | 0.464 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.447432e-01 | 0.463 |
| R-HSA-9679191 | Potential therapeutics for SARS | 3.468612e-01 | 0.460 |
| R-HSA-202424 | Downstream TCR signaling | 3.482921e-01 | 0.458 |
| R-HSA-73884 | Base Excision Repair | 3.482921e-01 | 0.458 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.494666e-01 | 0.457 |
| R-HSA-180024 | DARPP-32 events | 3.528484e-01 | 0.452 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.572340e-01 | 0.447 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.608539e-01 | 0.443 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.608539e-01 | 0.443 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.608539e-01 | 0.443 |
| R-HSA-1989781 | PPARA activates gene expression | 3.637066e-01 | 0.439 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.687608e-01 | 0.433 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.687608e-01 | 0.433 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.704274e-01 | 0.431 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.765704e-01 | 0.424 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.765704e-01 | 0.424 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.765704e-01 | 0.424 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.769225e-01 | 0.424 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.810811e-01 | 0.419 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.837822e-01 | 0.416 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.842839e-01 | 0.415 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.842839e-01 | 0.415 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.842839e-01 | 0.415 |
| R-HSA-9930044 | Nuclear RNA decay | 3.842839e-01 | 0.415 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.842839e-01 | 0.415 |
| R-HSA-157579 | Telomere Maintenance | 3.881624e-01 | 0.411 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.919024e-01 | 0.407 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.919024e-01 | 0.407 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.919024e-01 | 0.407 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.919024e-01 | 0.407 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.968817e-01 | 0.401 |
| R-HSA-3214847 | HATs acetylate histones | 3.968817e-01 | 0.401 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.994271e-01 | 0.399 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.994271e-01 | 0.399 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.994271e-01 | 0.399 |
| R-HSA-5673000 | RAF activation | 3.994271e-01 | 0.399 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.994271e-01 | 0.399 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.012200e-01 | 0.397 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.055438e-01 | 0.392 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.068592e-01 | 0.391 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.068592e-01 | 0.391 |
| R-HSA-169911 | Regulation of Apoptosis | 4.068592e-01 | 0.391 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.068592e-01 | 0.391 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.068592e-01 | 0.391 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.098526e-01 | 0.387 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.098526e-01 | 0.387 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.141997e-01 | 0.383 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.141997e-01 | 0.383 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.141997e-01 | 0.383 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.141997e-01 | 0.383 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.141997e-01 | 0.383 |
| R-HSA-111933 | Calmodulin induced events | 4.141997e-01 | 0.383 |
| R-HSA-111997 | CaM pathway | 4.141997e-01 | 0.383 |
| R-HSA-3371511 | HSF1 activation | 4.141997e-01 | 0.383 |
| R-HSA-163560 | Triglyceride catabolism | 4.141997e-01 | 0.383 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.141997e-01 | 0.383 |
| R-HSA-8853659 | RET signaling | 4.141997e-01 | 0.383 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.184244e-01 | 0.378 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.184244e-01 | 0.378 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.203167e-01 | 0.376 |
| R-HSA-4641258 | Degradation of DVL | 4.214498e-01 | 0.375 |
| R-HSA-4641257 | Degradation of AXIN | 4.214498e-01 | 0.375 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.214498e-01 | 0.375 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.214498e-01 | 0.375 |
| R-HSA-419037 | NCAM1 interactions | 4.214498e-01 | 0.375 |
| R-HSA-71064 | Lysine catabolism | 4.214498e-01 | 0.375 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.268786e-01 | 0.370 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.269333e-01 | 0.370 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 4.286107e-01 | 0.368 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.356833e-01 | 0.361 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.356833e-01 | 0.361 |
| R-HSA-69541 | Stabilization of p53 | 4.356833e-01 | 0.361 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.356833e-01 | 0.361 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.395739e-01 | 0.357 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.395739e-01 | 0.357 |
| R-HSA-5260271 | Diseases of Immune System | 4.426689e-01 | 0.354 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.426689e-01 | 0.354 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.426689e-01 | 0.354 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.426689e-01 | 0.354 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.426689e-01 | 0.354 |
| R-HSA-202403 | TCR signaling | 4.479164e-01 | 0.349 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.495684e-01 | 0.347 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.495684e-01 | 0.347 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.495684e-01 | 0.347 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.495684e-01 | 0.347 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.561893e-01 | 0.341 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.561893e-01 | 0.341 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.563829e-01 | 0.341 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.563829e-01 | 0.341 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.631134e-01 | 0.334 |
| R-HSA-977444 | GABA B receptor activation | 4.631134e-01 | 0.334 |
| R-HSA-991365 | Activation of GABAB receptors | 4.631134e-01 | 0.334 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.631134e-01 | 0.334 |
| R-HSA-111996 | Ca-dependent events | 4.631134e-01 | 0.334 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.697611e-01 | 0.328 |
| R-HSA-8854214 | TBC/RABGAPs | 4.697611e-01 | 0.328 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.763268e-01 | 0.322 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.763268e-01 | 0.322 |
| R-HSA-69236 | G1 Phase | 4.763268e-01 | 0.322 |
| R-HSA-9907900 | Proteasome assembly | 4.763268e-01 | 0.322 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.801101e-01 | 0.319 |
| R-HSA-774815 | Nucleosome assembly | 4.828116e-01 | 0.316 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.828116e-01 | 0.316 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.828116e-01 | 0.316 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.828116e-01 | 0.316 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.828116e-01 | 0.316 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.828116e-01 | 0.316 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.828116e-01 | 0.316 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.828116e-01 | 0.316 |
| R-HSA-9824272 | Somitogenesis | 4.828116e-01 | 0.316 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.892165e-01 | 0.310 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.892165e-01 | 0.310 |
| R-HSA-75153 | Apoptotic execution phase | 4.892165e-01 | 0.310 |
| R-HSA-212436 | Generic Transcription Pathway | 4.906610e-01 | 0.309 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.939917e-01 | 0.306 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.949053e-01 | 0.305 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.955425e-01 | 0.305 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.955425e-01 | 0.305 |
| R-HSA-3371556 | Cellular response to heat stress | 5.003788e-01 | 0.301 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.017906e-01 | 0.299 |
| R-HSA-9634597 | GPER1 signaling | 5.017906e-01 | 0.299 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.017906e-01 | 0.299 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.079616e-01 | 0.294 |
| R-HSA-9766229 | Degradation of CDH1 | 5.079616e-01 | 0.294 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.079616e-01 | 0.294 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.079616e-01 | 0.294 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.081648e-01 | 0.294 |
| R-HSA-73894 | DNA Repair | 5.105985e-01 | 0.292 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 5.140566e-01 | 0.289 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.200764e-01 | 0.284 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.200764e-01 | 0.284 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.260221e-01 | 0.279 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.260221e-01 | 0.279 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.260221e-01 | 0.279 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.260221e-01 | 0.279 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.260221e-01 | 0.279 |
| R-HSA-72172 | mRNA Splicing | 5.275790e-01 | 0.278 |
| R-HSA-2262752 | Cellular responses to stress | 5.297031e-01 | 0.276 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.318944e-01 | 0.274 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.318944e-01 | 0.274 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.318944e-01 | 0.274 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.318944e-01 | 0.274 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.318944e-01 | 0.274 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.358644e-01 | 0.271 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.376944e-01 | 0.269 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.376944e-01 | 0.269 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.434228e-01 | 0.265 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.434228e-01 | 0.265 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.490806e-01 | 0.260 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.490806e-01 | 0.260 |
| R-HSA-75893 | TNF signaling | 5.490806e-01 | 0.260 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.490806e-01 | 0.260 |
| R-HSA-9909396 | Circadian clock | 5.495544e-01 | 0.260 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.535136e-01 | 0.257 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.546687e-01 | 0.256 |
| R-HSA-195721 | Signaling by WNT | 5.584915e-01 | 0.253 |
| R-HSA-9033241 | Peroxisomal protein import | 5.656389e-01 | 0.247 |
| R-HSA-8979227 | Triglyceride metabolism | 5.656389e-01 | 0.247 |
| R-HSA-186712 | Regulation of beta-cell development | 5.656389e-01 | 0.247 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.675480e-01 | 0.246 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.710227e-01 | 0.243 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.710227e-01 | 0.243 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.710227e-01 | 0.243 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.710227e-01 | 0.243 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.710227e-01 | 0.243 |
| R-HSA-977443 | GABA receptor activation | 5.710227e-01 | 0.243 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.710227e-01 | 0.243 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.710227e-01 | 0.243 |
| R-HSA-351202 | Metabolism of polyamines | 5.710227e-01 | 0.243 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.710227e-01 | 0.243 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.745998e-01 | 0.241 |
| R-HSA-112043 | PLC beta mediated events | 5.763402e-01 | 0.239 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.763402e-01 | 0.239 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.763402e-01 | 0.239 |
| R-HSA-450294 | MAP kinase activation | 5.763402e-01 | 0.239 |
| R-HSA-6807070 | PTEN Regulation | 5.780944e-01 | 0.238 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.780944e-01 | 0.238 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.815921e-01 | 0.235 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.815921e-01 | 0.235 |
| R-HSA-373755 | Semaphorin interactions | 5.867791e-01 | 0.232 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.918632e-01 | 0.228 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.919022e-01 | 0.228 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.952529e-01 | 0.225 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.963576e-01 | 0.224 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.969621e-01 | 0.224 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 5.986217e-01 | 0.223 |
| R-HSA-112040 | G-protein mediated events | 6.068954e-01 | 0.217 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.117703e-01 | 0.213 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.180949e-01 | 0.209 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.183941e-01 | 0.209 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.213403e-01 | 0.207 |
| R-HSA-448424 | Interleukin-17 signaling | 6.213403e-01 | 0.207 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.213403e-01 | 0.207 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.260370e-01 | 0.203 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.260370e-01 | 0.203 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.260370e-01 | 0.203 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.260370e-01 | 0.203 |
| R-HSA-73887 | Death Receptor Signaling | 6.311571e-01 | 0.200 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.352571e-01 | 0.197 |
| R-HSA-4086398 | Ca2+ pathway | 6.352571e-01 | 0.197 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.352571e-01 | 0.197 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.397819e-01 | 0.194 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.435868e-01 | 0.191 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.460030e-01 | 0.190 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.486648e-01 | 0.188 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.486648e-01 | 0.188 |
| R-HSA-5689603 | UCH proteinases | 6.486648e-01 | 0.188 |
| R-HSA-109581 | Apoptosis | 6.556855e-01 | 0.183 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.573296e-01 | 0.182 |
| R-HSA-191273 | Cholesterol biosynthesis | 6.573296e-01 | 0.182 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.573296e-01 | 0.182 |
| R-HSA-5619084 | ABC transporter disorders | 6.573296e-01 | 0.182 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.599131e-01 | 0.181 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 6.615820e-01 | 0.179 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.615820e-01 | 0.179 |
| R-HSA-5688426 | Deubiquitination | 6.655795e-01 | 0.177 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.657819e-01 | 0.177 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.657819e-01 | 0.177 |
| R-HSA-5619102 | SLC transporter disorders | 6.703475e-01 | 0.174 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.740266e-01 | 0.171 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.780728e-01 | 0.169 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.820690e-01 | 0.166 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.860158e-01 | 0.164 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.899139e-01 | 0.161 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.937638e-01 | 0.159 |
| R-HSA-597592 | Post-translational protein modification | 7.003252e-01 | 0.155 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 7.013215e-01 | 0.154 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.013215e-01 | 0.154 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.086936e-01 | 0.150 |
| R-HSA-6798695 | Neutrophil degranulation | 7.103814e-01 | 0.149 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.123115e-01 | 0.147 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.123115e-01 | 0.147 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.194137e-01 | 0.143 |
| R-HSA-9679506 | SARS-CoV Infections | 7.233098e-01 | 0.141 |
| R-HSA-1474290 | Collagen formation | 7.263414e-01 | 0.139 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.297412e-01 | 0.137 |
| R-HSA-983712 | Ion channel transport | 7.313929e-01 | 0.136 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.330989e-01 | 0.135 |
| R-HSA-1296071 | Potassium Channels | 7.364151e-01 | 0.133 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.396903e-01 | 0.131 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.429251e-01 | 0.129 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.429251e-01 | 0.129 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.429251e-01 | 0.129 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.429251e-01 | 0.129 |
| R-HSA-422356 | Regulation of insulin secretion | 7.429251e-01 | 0.129 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.461198e-01 | 0.127 |
| R-HSA-70171 | Glycolysis | 7.492750e-01 | 0.125 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.492750e-01 | 0.125 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.516513e-01 | 0.124 |
| R-HSA-111885 | Opioid Signalling | 7.615105e-01 | 0.118 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.636731e-01 | 0.117 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.636731e-01 | 0.117 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.636731e-01 | 0.117 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.674035e-01 | 0.115 |
| R-HSA-5357801 | Programmed Cell Death | 7.701389e-01 | 0.113 |
| R-HSA-418346 | Platelet homeostasis | 7.702955e-01 | 0.113 |
| R-HSA-211000 | Gene Silencing by RNA | 7.731517e-01 | 0.112 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.759725e-01 | 0.110 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.787585e-01 | 0.109 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.815099e-01 | 0.107 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.815099e-01 | 0.107 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.815099e-01 | 0.107 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.866359e-01 | 0.104 |
| R-HSA-1500931 | Cell-Cell communication | 7.892496e-01 | 0.103 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.895617e-01 | 0.103 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.895617e-01 | 0.103 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.947648e-01 | 0.100 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.973182e-01 | 0.098 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.998399e-01 | 0.097 |
| R-HSA-8951664 | Neddylation | 8.020876e-01 | 0.096 |
| R-HSA-8957322 | Metabolism of steroids | 8.022841e-01 | 0.096 |
| R-HSA-5663205 | Infectious disease | 8.040113e-01 | 0.095 |
| R-HSA-70326 | Glucose metabolism | 8.047902e-01 | 0.094 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.096185e-01 | 0.092 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.096185e-01 | 0.092 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.096185e-01 | 0.092 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.112358e-01 | 0.091 |
| R-HSA-68875 | Mitotic Prophase | 8.119880e-01 | 0.090 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 8.143281e-01 | 0.089 |
| R-HSA-449147 | Signaling by Interleukins | 8.164899e-01 | 0.088 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.166392e-01 | 0.088 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.166392e-01 | 0.088 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.189217e-01 | 0.087 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.189217e-01 | 0.087 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.211759e-01 | 0.086 |
| R-HSA-194138 | Signaling by VEGF | 8.256009e-01 | 0.083 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.277724e-01 | 0.082 |
| R-HSA-114608 | Platelet degranulation | 8.299170e-01 | 0.081 |
| R-HSA-168256 | Immune System | 8.335629e-01 | 0.079 |
| R-HSA-157118 | Signaling by NOTCH | 8.348824e-01 | 0.078 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.361926e-01 | 0.078 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.387448e-01 | 0.076 |
| R-HSA-5576891 | Cardiac conduction | 8.402478e-01 | 0.076 |
| R-HSA-9717189 | Sensory perception of taste | 8.402478e-01 | 0.076 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.442030e-01 | 0.074 |
| R-HSA-163685 | Integration of energy metabolism | 8.518237e-01 | 0.070 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.518237e-01 | 0.070 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.586204e-01 | 0.066 |
| R-HSA-1643685 | Disease | 8.657291e-01 | 0.063 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.741202e-01 | 0.058 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.787717e-01 | 0.056 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.802839e-01 | 0.055 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.802839e-01 | 0.055 |
| R-HSA-9609507 | Protein localization | 8.817773e-01 | 0.055 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.832521e-01 | 0.054 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.917246e-01 | 0.050 |
| R-HSA-418594 | G alpha (i) signalling events | 9.026190e-01 | 0.044 |
| R-HSA-1483257 | Phospholipid metabolism | 9.040162e-01 | 0.044 |
| R-HSA-72306 | tRNA processing | 9.056999e-01 | 0.043 |
| R-HSA-418555 | G alpha (s) signalling events | 9.068776e-01 | 0.042 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.080407e-01 | 0.042 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.091894e-01 | 0.041 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.091894e-01 | 0.041 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.091894e-01 | 0.041 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.091894e-01 | 0.041 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.275867e-01 | 0.033 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.320033e-01 | 0.031 |
| R-HSA-382551 | Transport of small molecules | 9.343624e-01 | 0.029 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.353428e-01 | 0.029 |
| R-HSA-397014 | Muscle contraction | 9.451092e-01 | 0.025 |
| R-HSA-418990 | Adherens junctions interactions | 9.491072e-01 | 0.023 |
| R-HSA-162906 | HIV Infection | 9.545673e-01 | 0.020 |
| R-HSA-8939211 | ESR-mediated signaling | 9.599528e-01 | 0.018 |
| R-HSA-421270 | Cell-cell junction organization | 9.664419e-01 | 0.015 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.671190e-01 | 0.015 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.711639e-01 | 0.013 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.729305e-01 | 0.012 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.749088e-01 | 0.011 |
| R-HSA-446728 | Cell junction organization | 9.761471e-01 | 0.010 |
| R-HSA-72766 | Translation | 9.766953e-01 | 0.010 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.770357e-01 | 0.010 |
| R-HSA-9658195 | Leishmania infection | 9.770357e-01 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 9.858864e-01 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 9.863479e-01 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.868499e-01 | 0.006 |
| R-HSA-1474244 | Extracellular matrix organization | 9.878162e-01 | 0.005 |
| R-HSA-388396 | GPCR downstream signalling | 9.900327e-01 | 0.004 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.918876e-01 | 0.004 |
| R-HSA-168249 | Innate Immune System | 9.952087e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.960745e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.967376e-01 | 0.001 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.970164e-01 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.975239e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999862e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK17 |
0.874 | 0.868 | 1 | 0.886 |
CDK19 |
0.872 | 0.823 | 1 | 0.842 |
CDK3 |
0.872 | 0.794 | 1 | 0.878 |
CDK18 |
0.871 | 0.842 | 1 | 0.856 |
CDK16 |
0.869 | 0.844 | 1 | 0.873 |
CDK8 |
0.867 | 0.825 | 1 | 0.807 |
P38G |
0.867 | 0.874 | 1 | 0.891 |
CDK1 |
0.864 | 0.835 | 1 | 0.839 |
P38D |
0.864 | 0.864 | 1 | 0.888 |
JNK2 |
0.863 | 0.875 | 1 | 0.853 |
CDK13 |
0.862 | 0.828 | 1 | 0.831 |
ERK1 |
0.861 | 0.837 | 1 | 0.833 |
CDK5 |
0.861 | 0.817 | 1 | 0.786 |
CDK7 |
0.861 | 0.811 | 1 | 0.811 |
CDK12 |
0.859 | 0.827 | 1 | 0.851 |
P38B |
0.857 | 0.834 | 1 | 0.816 |
KIS |
0.857 | 0.731 | 1 | 0.780 |
CDK14 |
0.856 | 0.828 | 1 | 0.819 |
HIPK2 |
0.855 | 0.752 | 1 | 0.831 |
CDK9 |
0.855 | 0.818 | 1 | 0.823 |
JNK3 |
0.854 | 0.865 | 1 | 0.825 |
CDK10 |
0.854 | 0.783 | 1 | 0.836 |
ERK2 |
0.851 | 0.844 | 1 | 0.788 |
DYRK2 |
0.850 | 0.744 | 1 | 0.747 |
P38A |
0.849 | 0.810 | 1 | 0.751 |
CDK6 |
0.849 | 0.808 | 1 | 0.835 |
CDK2 |
0.849 | 0.700 | 1 | 0.717 |
CDK4 |
0.846 | 0.819 | 1 | 0.859 |
NLK |
0.844 | 0.762 | 1 | 0.548 |
DYRK4 |
0.843 | 0.752 | 1 | 0.841 |
HIPK1 |
0.841 | 0.695 | 1 | 0.729 |
DYRK1B |
0.841 | 0.729 | 1 | 0.806 |
HIPK3 |
0.838 | 0.688 | 1 | 0.698 |
HIPK4 |
0.834 | 0.458 | 1 | 0.539 |
ERK5 |
0.834 | 0.432 | 1 | 0.458 |
CLK3 |
0.833 | 0.466 | 1 | 0.517 |
DYRK1A |
0.832 | 0.612 | 1 | 0.714 |
JNK1 |
0.831 | 0.771 | 1 | 0.854 |
SRPK1 |
0.823 | 0.325 | -3 | 0.774 |
CLK1 |
0.822 | 0.424 | -3 | 0.788 |
DYRK3 |
0.821 | 0.544 | 1 | 0.690 |
MTOR |
0.820 | 0.219 | 1 | 0.339 |
CDKL5 |
0.817 | 0.183 | -3 | 0.825 |
ICK |
0.815 | 0.349 | -3 | 0.859 |
CLK4 |
0.815 | 0.378 | -3 | 0.799 |
CDKL1 |
0.814 | 0.166 | -3 | 0.829 |
SRPK2 |
0.812 | 0.264 | -3 | 0.705 |
COT |
0.809 | -0.095 | 2 | 0.873 |
MAK |
0.809 | 0.484 | -2 | 0.756 |
ERK7 |
0.808 | 0.302 | 2 | 0.618 |
PRP4 |
0.807 | 0.452 | -3 | 0.760 |
MOK |
0.805 | 0.460 | 1 | 0.615 |
CLK2 |
0.804 | 0.377 | -3 | 0.772 |
MST4 |
0.804 | 0.016 | 2 | 0.898 |
PRPK |
0.804 | -0.104 | -1 | 0.880 |
NUAK2 |
0.803 | 0.047 | -3 | 0.861 |
CDC7 |
0.803 | -0.132 | 1 | 0.176 |
PKN3 |
0.802 | -0.018 | -3 | 0.852 |
TBK1 |
0.801 | -0.172 | 1 | 0.138 |
SRPK3 |
0.801 | 0.225 | -3 | 0.743 |
PRKD1 |
0.801 | -0.008 | -3 | 0.852 |
MOS |
0.800 | -0.061 | 1 | 0.214 |
PKCD |
0.800 | 0.022 | 2 | 0.872 |
PDHK4 |
0.800 | -0.162 | 1 | 0.224 |
IKKE |
0.800 | -0.166 | 1 | 0.136 |
ATR |
0.800 | -0.056 | 1 | 0.214 |
DSTYK |
0.800 | -0.112 | 2 | 0.898 |
GCN2 |
0.799 | -0.196 | 2 | 0.808 |
ULK2 |
0.799 | -0.171 | 2 | 0.805 |
CAMK1B |
0.799 | -0.029 | -3 | 0.890 |
RAF1 |
0.799 | -0.181 | 1 | 0.161 |
PDHK1 |
0.798 | -0.146 | 1 | 0.198 |
PKN2 |
0.798 | -0.025 | -3 | 0.862 |
PRKD2 |
0.797 | 0.006 | -3 | 0.808 |
NIK |
0.797 | -0.028 | -3 | 0.898 |
IKKB |
0.797 | -0.169 | -2 | 0.814 |
PIM3 |
0.796 | -0.049 | -3 | 0.844 |
BMPR2 |
0.796 | -0.179 | -2 | 0.894 |
WNK1 |
0.796 | -0.078 | -2 | 0.900 |
MLK1 |
0.795 | -0.086 | 2 | 0.878 |
MLK3 |
0.795 | 0.004 | 2 | 0.846 |
MAPKAPK3 |
0.793 | -0.041 | -3 | 0.807 |
NEK6 |
0.793 | -0.093 | -2 | 0.841 |
RSK2 |
0.792 | -0.011 | -3 | 0.808 |
NDR2 |
0.792 | -0.053 | -3 | 0.852 |
IRE1 |
0.792 | -0.071 | 1 | 0.156 |
MARK4 |
0.791 | -0.057 | 4 | 0.814 |
PINK1 |
0.791 | 0.205 | 1 | 0.373 |
NUAK1 |
0.791 | -0.004 | -3 | 0.825 |
P90RSK |
0.790 | -0.012 | -3 | 0.804 |
CAMK2G |
0.790 | -0.117 | 2 | 0.779 |
IRE2 |
0.790 | -0.045 | 2 | 0.822 |
PKCA |
0.790 | 0.023 | 2 | 0.836 |
BCKDK |
0.790 | -0.141 | -1 | 0.864 |
CAMLCK |
0.789 | -0.039 | -2 | 0.868 |
NEK7 |
0.789 | -0.176 | -3 | 0.840 |
NDR1 |
0.789 | -0.076 | -3 | 0.858 |
PKCB |
0.789 | 0.014 | 2 | 0.847 |
AMPKA1 |
0.789 | -0.062 | -3 | 0.876 |
TSSK2 |
0.789 | -0.056 | -5 | 0.887 |
MLK2 |
0.789 | -0.109 | 2 | 0.866 |
WNK3 |
0.789 | -0.182 | 1 | 0.159 |
ULK1 |
0.789 | -0.169 | -3 | 0.825 |
PHKG1 |
0.789 | -0.039 | -3 | 0.846 |
DAPK2 |
0.789 | -0.054 | -3 | 0.890 |
PIM1 |
0.788 | 0.011 | -3 | 0.804 |
PRKD3 |
0.788 | 0.000 | -3 | 0.783 |
PKCG |
0.788 | 0.004 | 2 | 0.836 |
NEK9 |
0.788 | -0.151 | 2 | 0.865 |
TGFBR2 |
0.787 | -0.122 | -2 | 0.752 |
CHAK2 |
0.787 | -0.101 | -1 | 0.846 |
RIPK3 |
0.787 | -0.171 | 3 | 0.719 |
TSSK1 |
0.786 | -0.042 | -3 | 0.892 |
MAPKAPK2 |
0.786 | -0.027 | -3 | 0.761 |
NIM1 |
0.786 | -0.081 | 3 | 0.748 |
AMPKA2 |
0.786 | -0.041 | -3 | 0.849 |
DNAPK |
0.786 | -0.041 | 1 | 0.205 |
CAMK2D |
0.785 | -0.106 | -3 | 0.867 |
MELK |
0.785 | -0.059 | -3 | 0.841 |
PKCH |
0.785 | -0.009 | 2 | 0.821 |
HUNK |
0.785 | -0.171 | 2 | 0.777 |
PHKG2 |
0.784 | -0.014 | -3 | 0.838 |
RSK3 |
0.784 | -0.040 | -3 | 0.799 |
YSK4 |
0.784 | -0.106 | 1 | 0.143 |
PKCZ |
0.783 | -0.033 | 2 | 0.840 |
PKR |
0.783 | -0.062 | 1 | 0.178 |
QIK |
0.783 | -0.076 | -3 | 0.859 |
LATS2 |
0.783 | -0.058 | -5 | 0.795 |
ANKRD3 |
0.783 | -0.153 | 1 | 0.174 |
MASTL |
0.782 | -0.197 | -2 | 0.855 |
SKMLCK |
0.782 | -0.103 | -2 | 0.851 |
NEK2 |
0.782 | -0.103 | 2 | 0.850 |
IKKA |
0.782 | -0.122 | -2 | 0.788 |
P70S6KB |
0.782 | -0.039 | -3 | 0.830 |
GRK5 |
0.781 | -0.186 | -3 | 0.846 |
CAMK4 |
0.781 | -0.105 | -3 | 0.849 |
ATM |
0.781 | -0.087 | 1 | 0.182 |
QSK |
0.780 | -0.031 | 4 | 0.804 |
MNK2 |
0.780 | -0.059 | -2 | 0.810 |
DLK |
0.779 | -0.217 | 1 | 0.171 |
PAK6 |
0.779 | -0.031 | -2 | 0.754 |
CHK1 |
0.778 | -0.037 | -3 | 0.856 |
RIPK1 |
0.778 | -0.218 | 1 | 0.148 |
VRK2 |
0.778 | 0.004 | 1 | 0.257 |
PKCT |
0.778 | -0.014 | 2 | 0.829 |
SIK |
0.778 | -0.034 | -3 | 0.792 |
MLK4 |
0.778 | -0.081 | 2 | 0.803 |
MNK1 |
0.777 | -0.034 | -2 | 0.823 |
GRK6 |
0.777 | -0.153 | 1 | 0.160 |
SMG1 |
0.777 | -0.089 | 1 | 0.199 |
LATS1 |
0.777 | -0.016 | -3 | 0.863 |
PKACG |
0.776 | -0.070 | -2 | 0.744 |
AKT2 |
0.776 | 0.022 | -3 | 0.726 |
MPSK1 |
0.776 | 0.018 | 1 | 0.226 |
AURC |
0.776 | -0.029 | -2 | 0.659 |
PAK3 |
0.776 | -0.103 | -2 | 0.811 |
MST3 |
0.775 | -0.004 | 2 | 0.891 |
PKCI |
0.775 | 0.004 | 2 | 0.822 |
CHAK1 |
0.775 | -0.139 | 2 | 0.782 |
GRK1 |
0.775 | -0.096 | -2 | 0.794 |
PIM2 |
0.774 | 0.010 | -3 | 0.786 |
MEK1 |
0.774 | -0.144 | 2 | 0.824 |
IRAK4 |
0.774 | -0.094 | 1 | 0.136 |
PKN1 |
0.774 | 0.005 | -3 | 0.769 |
BRSK2 |
0.774 | -0.091 | -3 | 0.848 |
ALK4 |
0.774 | -0.107 | -2 | 0.800 |
MSK2 |
0.774 | -0.061 | -3 | 0.765 |
MARK3 |
0.773 | -0.037 | 4 | 0.775 |
MARK2 |
0.773 | -0.044 | 4 | 0.732 |
BMPR1B |
0.773 | -0.089 | 1 | 0.148 |
PAK1 |
0.772 | -0.088 | -2 | 0.799 |
HRI |
0.772 | -0.127 | -2 | 0.847 |
ZAK |
0.772 | -0.122 | 1 | 0.147 |
SGK3 |
0.772 | -0.028 | -3 | 0.797 |
PKCE |
0.772 | 0.043 | 2 | 0.827 |
TTBK2 |
0.771 | -0.216 | 2 | 0.705 |
BRSK1 |
0.771 | -0.075 | -3 | 0.819 |
CAMK2A |
0.771 | -0.052 | 2 | 0.761 |
GSK3A |
0.771 | 0.158 | 4 | 0.367 |
CAMK1G |
0.771 | -0.053 | -3 | 0.796 |
MEKK1 |
0.770 | -0.125 | 1 | 0.167 |
SNRK |
0.770 | -0.148 | 2 | 0.700 |
DRAK1 |
0.770 | -0.138 | 1 | 0.145 |
PKG2 |
0.770 | -0.034 | -2 | 0.683 |
MAPKAPK5 |
0.770 | -0.084 | -3 | 0.750 |
RSK4 |
0.770 | -0.024 | -3 | 0.769 |
CAMK2B |
0.770 | -0.091 | 2 | 0.734 |
TGFBR1 |
0.769 | -0.108 | -2 | 0.761 |
PLK1 |
0.769 | -0.170 | -2 | 0.793 |
MEK5 |
0.769 | -0.142 | 2 | 0.842 |
WNK4 |
0.769 | -0.121 | -2 | 0.898 |
AKT1 |
0.769 | 0.003 | -3 | 0.743 |
TAO2 |
0.769 | 0.003 | 2 | 0.895 |
MEKK2 |
0.769 | -0.100 | 2 | 0.844 |
FAM20C |
0.768 | -0.056 | 2 | 0.548 |
TAO3 |
0.768 | -0.029 | 1 | 0.191 |
SSTK |
0.768 | -0.043 | 4 | 0.793 |
MARK1 |
0.767 | -0.071 | 4 | 0.790 |
AURB |
0.767 | -0.050 | -2 | 0.655 |
SBK |
0.767 | 0.131 | -3 | 0.617 |
PAK2 |
0.767 | -0.110 | -2 | 0.793 |
BRAF |
0.767 | -0.118 | -4 | 0.847 |
PERK |
0.767 | -0.159 | -2 | 0.833 |
MYLK4 |
0.767 | -0.061 | -2 | 0.776 |
GRK7 |
0.766 | -0.052 | 1 | 0.190 |
MEKK3 |
0.766 | -0.161 | 1 | 0.164 |
ACVR2A |
0.766 | -0.130 | -2 | 0.762 |
PKACB |
0.765 | -0.022 | -2 | 0.670 |
HGK |
0.764 | -0.029 | 3 | 0.847 |
SMMLCK |
0.764 | -0.038 | -3 | 0.851 |
DCAMKL1 |
0.764 | -0.068 | -3 | 0.814 |
DCAMKL2 |
0.763 | -0.062 | -3 | 0.843 |
MSK1 |
0.763 | -0.057 | -3 | 0.772 |
NEK5 |
0.763 | -0.157 | 1 | 0.157 |
ACVR2B |
0.762 | -0.143 | -2 | 0.770 |
PLK4 |
0.762 | -0.163 | 2 | 0.617 |
ALK2 |
0.762 | -0.128 | -2 | 0.773 |
TNIK |
0.762 | -0.007 | 3 | 0.846 |
NEK11 |
0.761 | -0.129 | 1 | 0.186 |
GRK4 |
0.761 | -0.236 | -2 | 0.800 |
MEKK6 |
0.761 | -0.077 | 1 | 0.166 |
PLK3 |
0.761 | -0.152 | 2 | 0.726 |
NEK8 |
0.761 | -0.123 | 2 | 0.865 |
GCK |
0.760 | -0.058 | 1 | 0.180 |
GAK |
0.760 | -0.039 | 1 | 0.217 |
LOK |
0.760 | -0.041 | -2 | 0.841 |
MINK |
0.760 | -0.073 | 1 | 0.149 |
MAP3K15 |
0.760 | -0.086 | 1 | 0.160 |
TLK2 |
0.759 | -0.196 | 1 | 0.156 |
NEK4 |
0.759 | -0.121 | 1 | 0.146 |
P70S6K |
0.759 | -0.053 | -3 | 0.751 |
BUB1 |
0.759 | 0.019 | -5 | 0.782 |
PDK1 |
0.758 | -0.074 | 1 | 0.194 |
CAMKK1 |
0.758 | -0.148 | -2 | 0.871 |
PRKX |
0.758 | -0.003 | -3 | 0.708 |
GSK3B |
0.758 | 0.008 | 4 | 0.359 |
HPK1 |
0.758 | -0.054 | 1 | 0.178 |
MST2 |
0.757 | -0.086 | 1 | 0.158 |
KHS1 |
0.757 | -0.026 | 1 | 0.167 |
LRRK2 |
0.757 | -0.006 | 2 | 0.861 |
LKB1 |
0.757 | -0.081 | -3 | 0.840 |
CHK2 |
0.756 | -0.007 | -3 | 0.681 |
IRAK1 |
0.756 | -0.191 | -1 | 0.797 |
EEF2K |
0.756 | -0.046 | 3 | 0.820 |
BMPR1A |
0.756 | -0.102 | 1 | 0.139 |
YSK1 |
0.756 | -0.053 | 2 | 0.866 |
PAK5 |
0.756 | -0.070 | -2 | 0.683 |
KHS2 |
0.756 | -0.004 | 1 | 0.183 |
GRK2 |
0.755 | -0.121 | -2 | 0.688 |
TTBK1 |
0.755 | -0.160 | 2 | 0.620 |
PBK |
0.754 | -0.036 | 1 | 0.197 |
CAMK1D |
0.754 | -0.046 | -3 | 0.726 |
AURA |
0.754 | -0.068 | -2 | 0.610 |
CAMKK2 |
0.754 | -0.129 | -2 | 0.868 |
TAK1 |
0.754 | -0.118 | 1 | 0.153 |
AKT3 |
0.753 | 0.006 | -3 | 0.661 |
SLK |
0.753 | -0.046 | -2 | 0.781 |
PKACA |
0.753 | -0.026 | -2 | 0.623 |
NEK1 |
0.753 | -0.118 | 1 | 0.138 |
TLK1 |
0.752 | -0.192 | -2 | 0.776 |
MST1 |
0.752 | -0.078 | 1 | 0.148 |
HASPIN |
0.752 | 0.018 | -1 | 0.697 |
RIPK2 |
0.751 | -0.169 | 1 | 0.131 |
PASK |
0.751 | -0.085 | -3 | 0.854 |
NEK3 |
0.750 | -0.087 | 1 | 0.160 |
CAMK1A |
0.750 | -0.020 | -3 | 0.697 |
BIKE |
0.748 | -0.013 | 1 | 0.207 |
PAK4 |
0.748 | -0.070 | -2 | 0.673 |
CK2A2 |
0.748 | -0.068 | 1 | 0.133 |
SGK1 |
0.747 | 0.013 | -3 | 0.647 |
TAO1 |
0.746 | -0.022 | 1 | 0.156 |
DAPK3 |
0.746 | -0.065 | -3 | 0.821 |
MRCKB |
0.745 | -0.026 | -3 | 0.777 |
AAK1 |
0.745 | 0.021 | 1 | 0.213 |
MYO3B |
0.744 | -0.022 | 2 | 0.878 |
VRK1 |
0.744 | -0.176 | 2 | 0.845 |
CK1E |
0.743 | -0.086 | -3 | 0.484 |
MYO3A |
0.743 | -0.017 | 1 | 0.167 |
MRCKA |
0.742 | -0.045 | -3 | 0.792 |
DMPK1 |
0.741 | 0.014 | -3 | 0.797 |
ROCK2 |
0.740 | -0.044 | -3 | 0.816 |
MEK2 |
0.740 | -0.199 | 2 | 0.804 |
CK2A1 |
0.740 | -0.077 | 1 | 0.125 |
ASK1 |
0.738 | -0.105 | 1 | 0.157 |
CK1D |
0.737 | -0.060 | -3 | 0.429 |
PDHK3_TYR |
0.737 | 0.076 | 4 | 0.828 |
PKG1 |
0.737 | -0.048 | -2 | 0.617 |
DAPK1 |
0.737 | -0.074 | -3 | 0.803 |
STK33 |
0.736 | -0.161 | 2 | 0.614 |
TESK1_TYR |
0.735 | 0.038 | 3 | 0.854 |
LIMK2_TYR |
0.735 | 0.104 | -3 | 0.911 |
OSR1 |
0.734 | -0.087 | 2 | 0.828 |
CK1G1 |
0.734 | -0.124 | -3 | 0.471 |
PKMYT1_TYR |
0.733 | 0.117 | 3 | 0.829 |
GRK3 |
0.732 | -0.138 | -2 | 0.623 |
ROCK1 |
0.732 | -0.038 | -3 | 0.790 |
PLK2 |
0.731 | -0.105 | -3 | 0.783 |
TTK |
0.731 | -0.091 | -2 | 0.779 |
CRIK |
0.730 | -0.021 | -3 | 0.743 |
CK1A2 |
0.730 | -0.087 | -3 | 0.431 |
PINK1_TYR |
0.729 | -0.061 | 1 | 0.212 |
PDHK4_TYR |
0.728 | -0.003 | 2 | 0.860 |
MAP2K7_TYR |
0.727 | -0.095 | 2 | 0.850 |
LIMK1_TYR |
0.727 | 0.028 | 2 | 0.863 |
MAP2K4_TYR |
0.726 | -0.057 | -1 | 0.900 |
TYK2 |
0.725 | -0.131 | 1 | 0.162 |
MAP2K6_TYR |
0.724 | -0.038 | -1 | 0.902 |
TNNI3K_TYR |
0.724 | 0.011 | 1 | 0.187 |
JAK2 |
0.723 | -0.087 | 1 | 0.182 |
BMPR2_TYR |
0.722 | -0.028 | -1 | 0.877 |
ROS1 |
0.721 | -0.091 | 3 | 0.785 |
MST1R |
0.721 | -0.091 | 3 | 0.808 |
JAK1 |
0.721 | -0.041 | 1 | 0.154 |
RET |
0.721 | -0.145 | 1 | 0.176 |
NEK10_TYR |
0.720 | -0.095 | 1 | 0.158 |
ALPHAK3 |
0.720 | -0.113 | -1 | 0.782 |
CSF1R |
0.719 | -0.082 | 3 | 0.797 |
PDHK1_TYR |
0.718 | -0.119 | -1 | 0.903 |
STLK3 |
0.717 | -0.176 | 1 | 0.134 |
TYRO3 |
0.717 | -0.143 | 3 | 0.811 |
EPHA6 |
0.717 | -0.101 | -1 | 0.871 |
JAK3 |
0.715 | -0.116 | 1 | 0.168 |
DDR1 |
0.714 | -0.126 | 4 | 0.755 |
FGFR1 |
0.713 | -0.029 | 3 | 0.772 |
FLT3 |
0.712 | -0.119 | 3 | 0.806 |
TEK |
0.712 | -0.010 | 3 | 0.759 |
TNK1 |
0.712 | -0.077 | 3 | 0.781 |
EPHB4 |
0.711 | -0.148 | -1 | 0.863 |
PDGFRB |
0.711 | -0.161 | 3 | 0.814 |
PDGFRA |
0.711 | -0.140 | 3 | 0.817 |
FGFR2 |
0.710 | -0.060 | 3 | 0.778 |
YANK3 |
0.709 | -0.092 | 2 | 0.385 |
WEE1_TYR |
0.708 | -0.052 | -1 | 0.770 |
INSRR |
0.708 | -0.139 | 3 | 0.755 |
KDR |
0.707 | -0.086 | 3 | 0.758 |
YES1 |
0.707 | -0.120 | -1 | 0.866 |
FGR |
0.706 | -0.177 | 1 | 0.152 |
ABL2 |
0.706 | -0.149 | -1 | 0.817 |
KIT |
0.706 | -0.133 | 3 | 0.800 |
FER |
0.705 | -0.198 | 1 | 0.161 |
HCK |
0.705 | -0.153 | -1 | 0.839 |
TNK2 |
0.703 | -0.141 | 3 | 0.768 |
TXK |
0.703 | -0.134 | 1 | 0.143 |
ALK |
0.703 | -0.121 | 3 | 0.752 |
LCK |
0.703 | -0.120 | -1 | 0.837 |
ABL1 |
0.703 | -0.148 | -1 | 0.813 |
EPHB1 |
0.702 | -0.180 | 1 | 0.139 |
EPHA4 |
0.701 | -0.123 | 2 | 0.724 |
EPHB3 |
0.700 | -0.176 | -1 | 0.853 |
ITK |
0.700 | -0.175 | -1 | 0.820 |
AXL |
0.699 | -0.186 | 3 | 0.774 |
BTK |
0.698 | -0.192 | -1 | 0.787 |
FGFR3 |
0.698 | -0.081 | 3 | 0.755 |
DDR2 |
0.698 | -0.054 | 3 | 0.744 |
SRMS |
0.698 | -0.212 | 1 | 0.136 |
FLT4 |
0.697 | -0.137 | 3 | 0.738 |
TEC |
0.697 | -0.148 | -1 | 0.751 |
BLK |
0.697 | -0.119 | -1 | 0.838 |
EPHB2 |
0.697 | -0.172 | -1 | 0.841 |
LTK |
0.697 | -0.158 | 3 | 0.757 |
NTRK2 |
0.696 | -0.184 | 3 | 0.762 |
MERTK |
0.695 | -0.190 | 3 | 0.767 |
MUSK |
0.694 | -0.107 | 1 | 0.109 |
FLT1 |
0.694 | -0.144 | -1 | 0.854 |
ERBB2 |
0.694 | -0.172 | 1 | 0.150 |
MET |
0.694 | -0.151 | 3 | 0.790 |
FRK |
0.694 | -0.150 | -1 | 0.836 |
EPHA1 |
0.694 | -0.166 | 3 | 0.774 |
EPHA7 |
0.693 | -0.151 | 2 | 0.738 |
INSR |
0.693 | -0.163 | 3 | 0.726 |
NTRK1 |
0.692 | -0.220 | -1 | 0.853 |
BMX |
0.690 | -0.157 | -1 | 0.708 |
PTK6 |
0.690 | -0.213 | -1 | 0.771 |
EPHA3 |
0.690 | -0.159 | 2 | 0.710 |
PTK2B |
0.689 | -0.120 | -1 | 0.797 |
LYN |
0.689 | -0.150 | 3 | 0.718 |
NTRK3 |
0.689 | -0.165 | -1 | 0.803 |
FYN |
0.688 | -0.124 | -1 | 0.815 |
CK1A |
0.687 | -0.114 | -3 | 0.331 |
EGFR |
0.687 | -0.127 | 1 | 0.121 |
MATK |
0.684 | -0.122 | -1 | 0.738 |
EPHA8 |
0.684 | -0.138 | -1 | 0.821 |
EPHA5 |
0.683 | -0.166 | 2 | 0.716 |
CSK |
0.682 | -0.159 | 2 | 0.742 |
SRC |
0.681 | -0.148 | -1 | 0.820 |
FGFR4 |
0.680 | -0.126 | -1 | 0.789 |
PTK2 |
0.677 | -0.091 | -1 | 0.796 |
IGF1R |
0.675 | -0.160 | 3 | 0.673 |
YANK2 |
0.674 | -0.112 | 2 | 0.405 |
EPHA2 |
0.673 | -0.153 | -1 | 0.779 |
ERBB4 |
0.671 | -0.123 | 1 | 0.127 |
SYK |
0.671 | -0.129 | -1 | 0.778 |
CK1G3 |
0.670 | -0.110 | -3 | 0.279 |
FES |
0.663 | -0.149 | -1 | 0.705 |
ZAP70 |
0.655 | -0.103 | -1 | 0.686 |
CK1G2 |
0.639 | -0.128 | -3 | 0.380 |