Motif 298 (n=138)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S553 | ochoa | Golgin A8 family member Q | None |
| A5YKK6 | CNOT1 | S1014 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6NEL2 | SOWAHB | S166 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A6NJT0 | UNCX | S341 | ochoa | Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) | Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}. |
| A6NMD2 | GOLGA8J | S553 | ochoa | Golgin subfamily A member 8J | None |
| A6NNA2 | SRRM3 | S342 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
| A6NNZ2 | TUBB8B | S275 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| A8CG34 | POM121C | S970 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| H3BSY2 | GOLGA8M | S553 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S552 | ochoa | Golgin subfamily A member 8R | None |
| O00268 | TAF4 | S109 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
| O14559 | ARHGAP33 | S780 | ochoa | Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) | May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}. |
| O15287 | FANCG | S387 | psp | Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. |
| O15492 | RGS16 | Y168 | psp | Regulator of G-protein signaling 16 (RGS16) (A28-RGS14P) (Retinal-specific RGS) (RGS-r) (hRGS-r) (Retinally abundant regulator of G-protein signaling) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity). {ECO:0000250|UniProtKB:P97428, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:18434541}. |
| O15534 | PER1 | S1006 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O15534 | PER1 | S1007 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43255 | SIAH2 | S28 | psp | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11483518, PubMed:19224863, PubMed:22878263, PubMed:9334332). Has some overlapping function with SIAH1 (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}. |
| O75376 | NCOR1 | S1699 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75444 | MAF | Y131 | psp | Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) | Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. {ECO:0000250, ECO:0000269|PubMed:12149651, ECO:0000269|PubMed:14998494, ECO:0000269|PubMed:15007382, ECO:0000269|PubMed:16247450, ECO:0000269|PubMed:19143053}. |
| O95071 | UBR5 | S1755 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95336 | PGLS | S52 | ochoa | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}. |
| O95503 | CBX6 | S246 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95782 | AP2A1 | S655 | ochoa | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| O95936 | EOMES | S107 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| O95936 | EOMES | S116 | ochoa | Eomesodermin homolog (T-box brain protein 2) (T-brain-2) (TBR-2) | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}. |
| P04350 | TUBB4A | S275 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | S275 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0C7T5 | ATXN1L | S251 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0CJ92 | GOLGA8H | S553 | ochoa | Golgin subfamily A member 8H | None |
| P0DPH7 | TUBA3C | Y262 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | Y262 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P16989 | YBX3 | S34 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17676 | CEBPB | S76 | psp | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P18887 | XRCC1 | S199 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P24928 | POLR2A | S1508 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P24928 | POLR2A | S1514 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P29966 | MARCKS | S83 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P33402 | GUCY1A2 | S41 | ochoa | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | Has guanylyl cyclase on binding to the beta-1 subunit.; FUNCTION: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. |
| P33402 | GUCY1A2 | S49 | ochoa | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | Has guanylyl cyclase on binding to the beta-1 subunit.; FUNCTION: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. |
| P35568 | IRS1 | S503 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P51617 | IRAK1 | S556 | ochoa | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P53804 | TTC3 | S1935 | ochoa | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}. |
| P55011 | SLC12A2 | S77 | ochoa|psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55011 | SLC12A2 | S79 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P57086 | SCAND1 | S52 | ochoa | SCAN domain-containing protein 1 | May regulate transcriptional activity. |
| P58012 | FOXL2 | S211 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P58012 | FOXL2 | Y215 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P68363 | TUBA1B | Y262 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | Y262 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68371 | TUBB4B | S275 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q02447 | SP3 | S73 | ochoa|psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q02641 | CACNB1 | S416 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q07065 | CKAP4 | S79 | ochoa | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| Q07352 | ZFP36L1 | S203 | psp | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15467755, PubMed:15538381, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25014217, PubMed:25106868, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}. |
| Q12948 | FOXC1 | S235 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13428 | TCOF1 | S967 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13885 | TUBB2A | S275 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14106 | TOB2 | S163 | ochoa|psp | Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2) | Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. |
| Q14160 | SCRIB | S1306 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14444 | CAPRIN1 | S21 | ochoa | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| Q14444 | CAPRIN1 | S24 | ochoa | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633). {ECO:0000269|PubMed:17210633, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:35979925, ECO:0000269|PubMed:36040869, ECO:0000269|PubMed:36279435}. |
| Q14814 | MEF2D | S219 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14980 | NUMA1 | S2087 | psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15047 | SETDB1 | T525 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15047 | SETDB1 | S528 | ochoa | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
| Q15080 | NCF4 | S161 | ochoa | Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (Probable). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (By similarity). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P04839, ECO:0000250|UniProtKB:P14598, ECO:0000305|PubMed:8280052}. |
| Q15434 | RBMS2 | S108 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q15772 | SPEG | S19 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q18PE1 | DOK7 | S422 | ochoa | Protein Dok-7 (Downstream of tyrosine kinase 7) | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}. |
| Q27J81 | INF2 | S382 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2YD98 | UVSSA | S480 | ochoa | UV-stimulated scaffold protein A | Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Acts as a key adapter that promotes recruitment of factors involved in TC-NER (PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II (PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II (PubMed:38316879). Not involved in processing oxidative damage (PubMed:22466612). {ECO:0000269|PubMed:22466610, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:32142649, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236}. |
| Q3ZCM7 | TUBB8 | S275 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q53H80 | AKIRIN2 | S35 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q53H80 | AKIRIN2 | S39 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q5T1J5 | CHCHD2P9 | S41 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q5T7P8 | SYT6 | S97 | ochoa | Synaptotagmin-6 (Synaptotagmin VI) (SytVI) | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}. |
| Q6BEB4 | SP5 | S126 | ochoa | Transcription factor Sp5 | Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}. |
| Q6DKI7 | PVRIG | S207 | ochoa | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}. |
| Q6F5E8 | CARMIL2 | S993 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6NV74 | CRACDL | S490 | ochoa | CRACD-like protein | None |
| Q6P1R3 | MSANTD2 | S83 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6PEY2 | TUBA3E | Y262 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6VMQ6 | ATF7IP | S852 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZN55 | ZNF574 | S717 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZNJ1 | NBEAL2 | S1636 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZNJ1 | NBEAL2 | T1642 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZS17 | RIPOR1 | S427 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZTI6 | RFLNA | S33 | ochoa | Refilin-A (Regulator of filamin protein A) (RefilinA) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}. |
| Q6ZUM4 | ARHGAP27 | S84 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q71U36 | TUBA1A | Y262 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q765P7 | MTSS2 | S649 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7Z7F0 | KHDC4 | S44 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q7Z7L8 | C11orf96 | S299 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86U90 | YRDC | S60 | ochoa | Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) | Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250|UniProtKB:Q3U5F4, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:31481669, ECO:0000269|PubMed:34545459}. |
| Q86V15 | CASZ1 | S741 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86VQ1 | GLCCI1 | S79 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86VQ1 | GLCCI1 | S105 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86VQ1 | GLCCI1 | S107 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q8IU81 | IRF2BP1 | S66 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IVW6 | ARID3B | S61 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8IVW6 | ARID3B | S330 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8IY33 | MICALL2 | S294 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IZ21 | PHACTR4 | S228 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N2M8 | CLASRP | S331 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N4B5 | PRR18 | S101 | ochoa | Proline-rich protein 18 | None |
| Q8N5W9 | RFLNB | S34 | ochoa | Refilin-B (Regulator of filamin protein B) (RefilinB) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. {ECO:0000250|UniProtKB:Q5SVD0}. |
| Q8WZ73 | RFFL | S39 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92585 | MAML1 | S360 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92630 | DYRK2 | S48 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q96C12 | ARMC5 | S85 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96EB6 | SIRT1 | S47 | ochoa|psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96G74 | OTUD5 | Y175 | ochoa | OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}. |
| Q96ST8 | CEP89 | S44 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q99698 | LYST | S2089 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99700 | ATXN2 | S213 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQE3 | TUBA1C | Y262 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BTC0 | DIDO1 | S1285 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUF5 | TUBB6 | S275 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BUH8 | BEGAIN | S346 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BVA1 | TUBB2B | S275 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9C0C2 | TNKS1BP1 | S498 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9HBB8 | CDHR5 | S754 | ochoa | Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) | Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}. |
| Q9NR12 | PDLIM7 | S31 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NY65 | TUBA8 | Y262 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NZT2 | OGFR | S645 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P260 | RELCH | S56 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UBT2 | UBA2 | S207 | ochoa | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}. |
| Q9UGJ0 | PRKAG2 | S219 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UHR6 | ZNHIT2 | T161 | ochoa | Zinc finger HIT domain-containing protein 2 (Protein FON) | May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269|PubMed:28561026}. |
| Q9UHX1 | PUF60 | T314 | ochoa | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA. {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:11239393, ECO:0000269|PubMed:16452196, ECO:0000269|PubMed:16628215, ECO:0000269|PubMed:17579712}. |
| Q9UKA9 | PTBP2 | S308 | ochoa | Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein) | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. {ECO:0000250|UniProtKB:Q91Z31, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.; FUNCTION: [Isoform 5]: Reduced affinity for RNA. {ECO:0000269|PubMed:12213192}. |
| Q9UQ35 | SRRM2 | S2325 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2U8 | LEMD3 | S117 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y4R8 | TELO2 | S639 | ochoa | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
| Q9Y5J1 | UTP18 | S45 | ochoa | U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9Y5J1 | UTP18 | S46 | ochoa | U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}. |
| Q9Y5V3 | MAGED1 | S129 | ochoa | Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. |
| Q9Y6H1 | CHCHD2 | S41 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.110223e-16 | 15.955 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.110223e-16 | 15.955 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.110223e-16 | 15.955 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.110223e-16 | 15.955 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.110223e-16 | 15.955 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.110223e-16 | 15.955 |
| R-HSA-437239 | Recycling pathway of L1 | 1.110223e-16 | 15.955 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.110223e-16 | 15.955 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.110223e-16 | 15.955 |
| R-HSA-9646399 | Aggrephagy | 1.110223e-16 | 15.955 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.110223e-16 | 15.955 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.110223e-16 | 15.955 |
| R-HSA-190861 | Gap junction assembly | 1.110223e-16 | 15.955 |
| R-HSA-190828 | Gap junction trafficking | 1.110223e-16 | 15.955 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.110223e-16 | 15.955 |
| R-HSA-983189 | Kinesins | 1.110223e-16 | 15.955 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.110223e-16 | 15.955 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.110223e-16 | 15.955 |
| R-HSA-9833482 | PKR-mediated signaling | 2.220446e-16 | 15.654 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.440892e-16 | 15.353 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.551115e-16 | 15.256 |
| R-HSA-9663891 | Selective autophagy | 7.771561e-16 | 15.109 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.881784e-16 | 15.051 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.597922e-14 | 13.585 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.727952e-14 | 13.172 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.727952e-14 | 13.172 |
| R-HSA-373760 | L1CAM interactions | 6.772360e-14 | 13.169 |
| R-HSA-9609690 | HCMV Early Events | 9.237056e-14 | 13.034 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.488809e-13 | 12.827 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.920686e-13 | 12.717 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.838041e-13 | 12.416 |
| R-HSA-1632852 | Macroautophagy | 1.248113e-12 | 11.904 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.787459e-12 | 11.748 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.652856e-12 | 11.437 |
| R-HSA-5620924 | Intraflagellar transport | 4.722889e-12 | 11.326 |
| R-HSA-9609646 | HCMV Infection | 4.680478e-12 | 11.330 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.115797e-12 | 11.291 |
| R-HSA-9612973 | Autophagy | 5.189071e-12 | 11.285 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.445511e-12 | 11.191 |
| R-HSA-5617833 | Cilium Assembly | 7.277401e-12 | 11.138 |
| R-HSA-68877 | Mitotic Prometaphase | 9.069412e-12 | 11.042 |
| R-HSA-391251 | Protein folding | 1.075895e-11 | 10.968 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.940315e-11 | 10.532 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.902500e-11 | 10.537 |
| R-HSA-68882 | Mitotic Anaphase | 4.702994e-11 | 10.328 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.016298e-11 | 10.300 |
| R-HSA-69275 | G2/M Transition | 5.683698e-11 | 10.245 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.541201e-11 | 10.184 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.113624e-10 | 9.953 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.583251e-10 | 9.588 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.654397e-10 | 9.576 |
| R-HSA-68886 | M Phase | 5.552585e-10 | 9.256 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.357950e-09 | 8.867 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.533369e-09 | 8.814 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.814759e-09 | 8.235 |
| R-HSA-112316 | Neuronal System | 1.413249e-08 | 7.850 |
| R-HSA-913531 | Interferon Signaling | 2.225930e-08 | 7.652 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.648591e-07 | 6.783 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.649345e-07 | 6.577 |
| R-HSA-1640170 | Cell Cycle | 4.890739e-07 | 6.311 |
| R-HSA-422475 | Axon guidance | 6.764973e-07 | 6.170 |
| R-HSA-9675108 | Nervous system development | 1.712708e-06 | 5.766 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.936092e-06 | 5.003 |
| R-HSA-2262752 | Cellular responses to stress | 1.409188e-05 | 4.851 |
| R-HSA-1266738 | Developmental Biology | 1.416455e-05 | 4.849 |
| R-HSA-9824446 | Viral Infection Pathways | 2.443894e-05 | 4.612 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.158272e-05 | 4.501 |
| R-HSA-199991 | Membrane Trafficking | 9.273226e-05 | 4.033 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.708035e-04 | 3.567 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.526015e-04 | 3.344 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.526015e-04 | 3.344 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.450724e-04 | 3.264 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 8.155292e-04 | 3.089 |
| R-HSA-380287 | Centrosome maturation | 9.085096e-04 | 3.042 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 9.376470e-04 | 3.028 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.073425e-03 | 2.969 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.427468e-03 | 2.845 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.576797e-03 | 2.802 |
| R-HSA-109582 | Hemostasis | 2.070213e-03 | 2.684 |
| R-HSA-9909396 | Circadian clock | 2.130604e-03 | 2.671 |
| R-HSA-1280218 | Adaptive Immune System | 2.752944e-03 | 2.560 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.984032e-03 | 2.525 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 8.592778e-03 | 2.066 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 9.614194e-03 | 2.017 |
| R-HSA-167161 | HIV Transcription Initiation | 9.614194e-03 | 2.017 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 9.614194e-03 | 2.017 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 9.012579e-03 | 2.045 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 8.107239e-03 | 2.091 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.095057e-03 | 2.041 |
| R-HSA-5663205 | Infectious disease | 8.074527e-03 | 2.093 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.033247e-02 | 1.986 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.070347e-02 | 1.970 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.186139e-02 | 1.926 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.249268e-02 | 1.903 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.417112e-02 | 1.849 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.508766e-02 | 1.821 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.937186e-02 | 1.713 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.948273e-02 | 1.710 |
| R-HSA-162587 | HIV Life Cycle | 2.000789e-02 | 1.699 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.028206e-02 | 1.693 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.133881e-02 | 1.671 |
| R-HSA-597592 | Post-translational protein modification | 2.220945e-02 | 1.653 |
| R-HSA-162906 | HIV Infection | 2.287981e-02 | 1.641 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.577371e-02 | 1.589 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.365805e-02 | 1.626 |
| R-HSA-9707616 | Heme signaling | 2.454674e-02 | 1.610 |
| R-HSA-429947 | Deadenylation of mRNA | 2.925298e-02 | 1.534 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.454674e-02 | 1.610 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.577371e-02 | 1.589 |
| R-HSA-167172 | Transcription of the HIV genome | 3.025339e-02 | 1.519 |
| R-HSA-68875 | Mitotic Prophase | 3.155813e-02 | 1.501 |
| R-HSA-525793 | Myogenesis | 3.290799e-02 | 1.483 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.441255e-02 | 1.463 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.659760e-02 | 1.437 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.771632e-02 | 1.423 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.071697e-02 | 1.390 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.276816e-02 | 1.369 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.276816e-02 | 1.369 |
| R-HSA-74713 | IRS activation | 5.987370e-02 | 1.223 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.698349e-02 | 1.328 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.698349e-02 | 1.328 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.914600e-02 | 1.309 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.357676e-02 | 1.271 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 5.987370e-02 | 1.223 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.134401e-02 | 1.290 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.814336e-02 | 1.235 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.914600e-02 | 1.309 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.134401e-02 | 1.290 |
| R-HSA-9758941 | Gastrulation | 6.128279e-02 | 1.213 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.047571e-02 | 1.218 |
| R-HSA-162582 | Signal Transduction | 5.488242e-02 | 1.261 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.933552e-02 | 1.227 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 5.134401e-02 | 1.290 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.283977e-02 | 1.202 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.283977e-02 | 1.202 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.523482e-02 | 1.186 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.523482e-02 | 1.186 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.523482e-02 | 1.186 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.697399e-02 | 1.174 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 6.766014e-02 | 1.170 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.766014e-02 | 1.170 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 6.813133e-02 | 1.167 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 6.813133e-02 | 1.167 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 6.813133e-02 | 1.167 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.960492e-02 | 1.157 |
| R-HSA-112412 | SOS-mediated signalling | 8.443115e-02 | 1.073 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 1.161863e-01 | 0.935 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.239526e-01 | 0.907 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.316513e-01 | 0.881 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.316513e-01 | 0.881 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.316513e-01 | 0.881 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.468475e-01 | 0.833 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.543463e-01 | 0.812 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.908698e-01 | 0.719 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 8.280871e-02 | 1.082 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.120275e-01 | 0.674 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.120275e-01 | 0.674 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.157314e-01 | 0.937 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.887148e-01 | 0.724 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.050367e-01 | 0.688 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.259581e-01 | 0.900 |
| R-HSA-198203 | PI3K/AKT activation | 1.083515e-01 | 0.965 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.004478e-01 | 0.998 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.316513e-01 | 0.881 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.605294e-01 | 0.794 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.316513e-01 | 0.881 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.691481e-01 | 0.772 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.836926e-01 | 0.736 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 9.073650e-02 | 1.042 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.979843e-01 | 0.703 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 8.443115e-02 | 1.073 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.691481e-01 | 0.772 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.215028e-01 | 0.915 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.215028e-01 | 0.915 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.215028e-01 | 0.915 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.215028e-01 | 0.915 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.004478e-01 | 0.998 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.083515e-01 | 0.965 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.083515e-01 | 0.965 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.239526e-01 | 0.907 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.316513e-01 | 0.881 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.908698e-01 | 0.719 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 8.021630e-02 | 1.096 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.120275e-01 | 0.674 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.555824e-02 | 1.068 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.887148e-01 | 0.724 |
| R-HSA-74749 | Signal attenuation | 1.083515e-01 | 0.965 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 8.443115e-02 | 1.073 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.083515e-01 | 0.965 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.617797e-01 | 0.791 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.764523e-01 | 0.753 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.083515e-01 | 0.965 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.239526e-01 | 0.907 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.050367e-01 | 0.688 |
| R-HSA-191859 | snRNP Assembly | 1.186082e-01 | 0.926 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.186082e-01 | 0.926 |
| R-HSA-9610379 | HCMV Late Events | 2.014304e-01 | 0.696 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.215028e-01 | 0.915 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.698393e-01 | 0.770 |
| R-HSA-9842663 | Signaling by LTK | 1.316513e-01 | 0.881 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.900192e-02 | 1.102 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.513197e-01 | 0.820 |
| R-HSA-9843745 | Adipogenesis | 1.412863e-01 | 0.850 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.423653e-02 | 1.129 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 8.443115e-02 | 1.073 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.392827e-01 | 0.856 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.617797e-01 | 0.791 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.120275e-01 | 0.674 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.316513e-01 | 0.881 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.969412e-01 | 0.706 |
| R-HSA-4086400 | PCP/CE pathway | 1.760959e-01 | 0.754 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.234595e-01 | 0.908 |
| R-HSA-9613354 | Lipophagy | 1.004478e-01 | 0.998 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.316513e-01 | 0.881 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.316513e-01 | 0.881 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.316513e-01 | 0.881 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 8.280871e-02 | 1.082 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.120275e-01 | 0.674 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.691481e-01 | 0.772 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.836926e-01 | 0.736 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 8.443115e-02 | 1.073 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.691481e-01 | 0.772 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.120275e-01 | 0.674 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.273436e-01 | 0.895 |
| R-HSA-3371556 | Cellular response to heat stress | 1.177135e-01 | 0.929 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.004478e-01 | 0.998 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.691481e-01 | 0.772 |
| R-HSA-73887 | Death Receptor Signaling | 1.947060e-01 | 0.711 |
| R-HSA-2586552 | Signaling by Leptin | 1.083515e-01 | 0.965 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.120275e-01 | 0.674 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.186082e-01 | 0.926 |
| R-HSA-211000 | Gene Silencing by RNA | 8.892093e-02 | 1.051 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.908698e-01 | 0.719 |
| R-HSA-74160 | Gene expression (Transcription) | 1.565541e-01 | 0.805 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.332580e-01 | 0.875 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.215328e-01 | 0.915 |
| R-HSA-166520 | Signaling by NTRKs | 1.814359e-01 | 0.741 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.684282e-01 | 0.774 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.667255e-01 | 0.778 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 1.691481e-01 | 0.772 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.102152e-01 | 0.958 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.764523e-01 | 0.753 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.892093e-02 | 1.051 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.892093e-02 | 1.051 |
| R-HSA-168256 | Immune System | 1.936298e-01 | 0.713 |
| R-HSA-212436 | Generic Transcription Pathway | 1.524222e-01 | 0.817 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 8.806944e-02 | 1.055 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.855479e-01 | 0.732 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.128731e-01 | 0.947 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 9.887698e-02 | 1.005 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.189573e-01 | 0.660 |
| R-HSA-8964038 | LDL clearance | 2.189573e-01 | 0.660 |
| R-HSA-8953854 | Metabolism of RNA | 2.244950e-01 | 0.649 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.258265e-01 | 0.646 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.258265e-01 | 0.646 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.258265e-01 | 0.646 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.258265e-01 | 0.646 |
| R-HSA-200425 | Carnitine shuttle | 2.258265e-01 | 0.646 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.258265e-01 | 0.646 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.258265e-01 | 0.646 |
| R-HSA-1643685 | Disease | 2.286204e-01 | 0.641 |
| R-HSA-72306 | tRNA processing | 2.334777e-01 | 0.632 |
| R-HSA-9620244 | Long-term potentiation | 2.393855e-01 | 0.621 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.393855e-01 | 0.621 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.393855e-01 | 0.621 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.393855e-01 | 0.621 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.393855e-01 | 0.621 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.460764e-01 | 0.609 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.460764e-01 | 0.609 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.522634e-01 | 0.598 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.527087e-01 | 0.597 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.527087e-01 | 0.597 |
| R-HSA-168255 | Influenza Infection | 2.545459e-01 | 0.594 |
| R-HSA-70171 | Glycolysis | 2.564229e-01 | 0.591 |
| R-HSA-2559583 | Cellular Senescence | 2.569044e-01 | 0.590 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.592832e-01 | 0.586 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.592832e-01 | 0.586 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.592832e-01 | 0.586 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.592832e-01 | 0.586 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.592832e-01 | 0.586 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.592832e-01 | 0.586 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.592832e-01 | 0.586 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.629328e-01 | 0.580 |
| R-HSA-72086 | mRNA Capping | 2.658002e-01 | 0.575 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 2.658002e-01 | 0.575 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.694439e-01 | 0.570 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.722602e-01 | 0.565 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.722602e-01 | 0.565 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.722602e-01 | 0.565 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.726993e-01 | 0.564 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.726993e-01 | 0.564 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.786639e-01 | 0.555 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.786639e-01 | 0.555 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.850115e-01 | 0.545 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.901970e-01 | 0.537 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.913037e-01 | 0.536 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.913037e-01 | 0.536 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.913037e-01 | 0.536 |
| R-HSA-9733709 | Cardiogenesis | 2.913037e-01 | 0.536 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.913037e-01 | 0.536 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.987066e-01 | 0.525 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.037236e-01 | 0.518 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.037236e-01 | 0.518 |
| R-HSA-392499 | Metabolism of proteins | 3.063151e-01 | 0.514 |
| R-HSA-381042 | PERK regulates gene expression | 3.098523e-01 | 0.509 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.159274e-01 | 0.500 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.159274e-01 | 0.500 |
| R-HSA-8853659 | RET signaling | 3.159274e-01 | 0.500 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.159274e-01 | 0.500 |
| R-HSA-72172 | mRNA Splicing | 3.165826e-01 | 0.500 |
| R-HSA-70326 | Glucose metabolism | 3.213489e-01 | 0.493 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.219494e-01 | 0.492 |
| R-HSA-419037 | NCAM1 interactions | 3.219494e-01 | 0.492 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.219494e-01 | 0.492 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.279187e-01 | 0.484 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.279187e-01 | 0.484 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.338359e-01 | 0.476 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.338359e-01 | 0.476 |
| R-HSA-71336 | Pentose phosphate pathway | 3.338359e-01 | 0.476 |
| R-HSA-201556 | Signaling by ALK | 3.338359e-01 | 0.476 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.338359e-01 | 0.476 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.353541e-01 | 0.474 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.397013e-01 | 0.469 |
| R-HSA-167169 | HIV Transcription Elongation | 3.397013e-01 | 0.469 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.397013e-01 | 0.469 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.397013e-01 | 0.469 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.397013e-01 | 0.469 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.406173e-01 | 0.468 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.455154e-01 | 0.462 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.455154e-01 | 0.462 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.501903e-01 | 0.456 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.501903e-01 | 0.456 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.501903e-01 | 0.456 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.512787e-01 | 0.454 |
| R-HSA-165159 | MTOR signalling | 3.569917e-01 | 0.447 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.583426e-01 | 0.446 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.660398e-01 | 0.436 |
| R-HSA-5683826 | Surfactant metabolism | 3.682680e-01 | 0.434 |
| R-HSA-373752 | Netrin-1 signaling | 3.682680e-01 | 0.434 |
| R-HSA-1474165 | Reproduction | 3.691925e-01 | 0.433 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.738324e-01 | 0.427 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.738324e-01 | 0.427 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.741633e-01 | 0.427 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.793480e-01 | 0.421 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.848154e-01 | 0.415 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.848154e-01 | 0.415 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.884523e-01 | 0.411 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.902350e-01 | 0.409 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.910844e-01 | 0.408 |
| R-HSA-163685 | Integration of energy metabolism | 3.910844e-01 | 0.408 |
| R-HSA-109704 | PI3K Cascade | 4.009324e-01 | 0.397 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.009324e-01 | 0.397 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.114434e-01 | 0.386 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.114434e-01 | 0.386 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.114434e-01 | 0.386 |
| R-HSA-6798695 | Neutrophil degranulation | 4.137310e-01 | 0.383 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.166300e-01 | 0.380 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.166300e-01 | 0.380 |
| R-HSA-1221632 | Meiotic synapsis | 4.166300e-01 | 0.380 |
| R-HSA-4839726 | Chromatin organization | 4.238069e-01 | 0.373 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.268674e-01 | 0.370 |
| R-HSA-418597 | G alpha (z) signalling events | 4.268674e-01 | 0.370 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.268674e-01 | 0.370 |
| R-HSA-73894 | DNA Repair | 4.318020e-01 | 0.365 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.319191e-01 | 0.365 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.319191e-01 | 0.365 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.319191e-01 | 0.365 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.368011e-01 | 0.360 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.368011e-01 | 0.360 |
| R-HSA-112399 | IRS-mediated signalling | 4.369265e-01 | 0.360 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.418901e-01 | 0.355 |
| R-HSA-186712 | Regulation of beta-cell development | 4.468102e-01 | 0.350 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.486834e-01 | 0.348 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.516873e-01 | 0.345 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.516873e-01 | 0.345 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.565216e-01 | 0.341 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.565216e-01 | 0.341 |
| R-HSA-450294 | MAP kinase activation | 4.565216e-01 | 0.341 |
| R-HSA-9711097 | Cellular response to starvation | 4.604253e-01 | 0.337 |
| R-HSA-1268020 | Mitochondrial protein import | 4.613137e-01 | 0.336 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.613137e-01 | 0.336 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.660638e-01 | 0.332 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.707723e-01 | 0.327 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.707723e-01 | 0.327 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.707723e-01 | 0.327 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.754395e-01 | 0.323 |
| R-HSA-9830369 | Kidney development | 4.846518e-01 | 0.315 |
| R-HSA-5619102 | SLC transporter disorders | 4.863079e-01 | 0.313 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.885836e-01 | 0.311 |
| R-HSA-448424 | Interleukin-17 signaling | 4.981698e-01 | 0.303 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.981698e-01 | 0.303 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.025971e-01 | 0.299 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.069856e-01 | 0.295 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.069856e-01 | 0.295 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.113356e-01 | 0.291 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.156475e-01 | 0.288 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.156475e-01 | 0.288 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 5.156475e-01 | 0.288 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.156475e-01 | 0.288 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.270676e-01 | 0.278 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.283580e-01 | 0.277 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.325208e-01 | 0.274 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.325208e-01 | 0.274 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.407372e-01 | 0.267 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.407372e-01 | 0.267 |
| R-HSA-977225 | Amyloid fiber formation | 5.447914e-01 | 0.264 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.527936e-01 | 0.257 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.567422e-01 | 0.254 |
| R-HSA-1500620 | Meiosis | 5.606562e-01 | 0.251 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.606562e-01 | 0.251 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.645358e-01 | 0.248 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.683814e-01 | 0.245 |
| R-HSA-9679506 | SARS-CoV Infections | 5.767094e-01 | 0.239 |
| R-HSA-73884 | Base Excision Repair | 5.834295e-01 | 0.234 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.871094e-01 | 0.231 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.943727e-01 | 0.226 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.943727e-01 | 0.226 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.943727e-01 | 0.226 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.015091e-01 | 0.221 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.015091e-01 | 0.221 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.050303e-01 | 0.218 |
| R-HSA-397014 | Muscle contraction | 6.082637e-01 | 0.216 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.106071e-01 | 0.214 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.154099e-01 | 0.211 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.154099e-01 | 0.211 |
| R-HSA-157579 | Telomere Maintenance | 6.154099e-01 | 0.211 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.188092e-01 | 0.208 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.188092e-01 | 0.208 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.188092e-01 | 0.208 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.188092e-01 | 0.208 |
| R-HSA-190236 | Signaling by FGFR | 6.188092e-01 | 0.208 |
| R-HSA-422356 | Regulation of insulin secretion | 6.188092e-01 | 0.208 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.213042e-01 | 0.207 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.221787e-01 | 0.206 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.288291e-01 | 0.201 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.321106e-01 | 0.199 |
| R-HSA-1483255 | PI Metabolism | 6.321106e-01 | 0.199 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.342098e-01 | 0.198 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.385875e-01 | 0.195 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.449511e-01 | 0.190 |
| R-HSA-418346 | Platelet homeostasis | 6.480910e-01 | 0.188 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.542884e-01 | 0.184 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.542884e-01 | 0.184 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.573464e-01 | 0.182 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.603775e-01 | 0.180 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.603775e-01 | 0.180 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.693119e-01 | 0.174 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.693119e-01 | 0.174 |
| R-HSA-157118 | Signaling by NOTCH | 6.699031e-01 | 0.174 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.722378e-01 | 0.172 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.751381e-01 | 0.171 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.780129e-01 | 0.169 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.780129e-01 | 0.169 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.808624e-01 | 0.167 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 6.840427e-01 | 0.165 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.892616e-01 | 0.162 |
| R-HSA-5693538 | Homology Directed Repair | 6.892616e-01 | 0.162 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.920122e-01 | 0.160 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.920122e-01 | 0.160 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.920122e-01 | 0.160 |
| R-HSA-73886 | Chromosome Maintenance | 6.974412e-01 | 0.156 |
| R-HSA-5688426 | Deubiquitination | 6.995961e-01 | 0.155 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.001199e-01 | 0.155 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.001199e-01 | 0.155 |
| R-HSA-194138 | Signaling by VEGF | 7.106015e-01 | 0.148 |
| R-HSA-114608 | Platelet degranulation | 7.157050e-01 | 0.145 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.235228e-01 | 0.141 |
| R-HSA-5576891 | Cardiac conduction | 7.280761e-01 | 0.138 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.328736e-01 | 0.135 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.422177e-01 | 0.129 |
| R-HSA-6807070 | PTEN Regulation | 7.490122e-01 | 0.126 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.490122e-01 | 0.126 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.587891e-01 | 0.120 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.599434e-01 | 0.119 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.696567e-01 | 0.114 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.704017e-01 | 0.113 |
| R-HSA-195721 | Signaling by WNT | 7.726831e-01 | 0.112 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.784415e-01 | 0.109 |
| R-HSA-9609507 | Protein localization | 7.804074e-01 | 0.108 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.804074e-01 | 0.108 |
| R-HSA-1989781 | PPARA activates gene expression | 7.842874e-01 | 0.106 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.880993e-01 | 0.103 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.936920e-01 | 0.100 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.937789e-01 | 0.100 |
| R-HSA-109581 | Apoptosis | 7.973388e-01 | 0.098 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.129733e-01 | 0.090 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.162816e-01 | 0.088 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.179138e-01 | 0.087 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.179138e-01 | 0.087 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.179138e-01 | 0.087 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.367369e-01 | 0.077 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.407385e-01 | 0.075 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.449503e-01 | 0.073 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.517256e-01 | 0.070 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.538499e-01 | 0.069 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.569334e-01 | 0.067 |
| R-HSA-5357801 | Programmed Cell Death | 8.644066e-01 | 0.063 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.738442e-01 | 0.059 |
| R-HSA-418990 | Adherens junctions interactions | 8.792947e-01 | 0.056 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.876376e-01 | 0.052 |
| R-HSA-72312 | rRNA processing | 8.935166e-01 | 0.049 |
| R-HSA-8939211 | ESR-mediated signaling | 8.981817e-01 | 0.047 |
| R-HSA-421270 | Cell-cell junction organization | 9.101917e-01 | 0.041 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.141309e-01 | 0.039 |
| R-HSA-168249 | Innate Immune System | 9.157343e-01 | 0.038 |
| R-HSA-416476 | G alpha (q) signalling events | 9.200797e-01 | 0.036 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.269433e-01 | 0.033 |
| R-HSA-446728 | Cell junction organization | 9.295219e-01 | 0.032 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.320100e-01 | 0.031 |
| R-HSA-1483257 | Phospholipid metabolism | 9.395096e-01 | 0.027 |
| R-HSA-1500931 | Cell-Cell communication | 9.499271e-01 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.761198e-01 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 9.781874e-01 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 9.781874e-01 | 0.010 |
| R-HSA-449147 | Signaling by Interleukins | 9.792967e-01 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 9.988624e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.992455e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996514e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998951e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.807 | 0.621 | 1 | 0.866 |
HIPK2 |
0.805 | 0.579 | 1 | 0.900 |
CDK19 |
0.802 | 0.608 | 1 | 0.850 |
KIS |
0.800 | 0.537 | 1 | 0.851 |
JNK2 |
0.800 | 0.635 | 1 | 0.859 |
P38B |
0.799 | 0.630 | 1 | 0.884 |
P38G |
0.799 | 0.622 | 1 | 0.862 |
P38D |
0.798 | 0.629 | 1 | 0.878 |
DYRK2 |
0.798 | 0.562 | 1 | 0.884 |
CDK1 |
0.797 | 0.584 | 1 | 0.860 |
CDK3 |
0.797 | 0.538 | 1 | 0.863 |
CDK17 |
0.797 | 0.606 | 1 | 0.857 |
HIPK4 |
0.797 | 0.475 | 1 | 0.767 |
ERK1 |
0.797 | 0.609 | 1 | 0.886 |
CDK8 |
0.794 | 0.590 | 1 | 0.841 |
CDK7 |
0.794 | 0.582 | 1 | 0.854 |
JNK3 |
0.793 | 0.622 | 1 | 0.860 |
CDK5 |
0.791 | 0.577 | 1 | 0.848 |
CDK13 |
0.789 | 0.567 | 1 | 0.860 |
P38A |
0.789 | 0.603 | 1 | 0.868 |
CDK12 |
0.788 | 0.570 | 1 | 0.863 |
DYRK4 |
0.787 | 0.540 | 1 | 0.894 |
CLK3 |
0.787 | 0.410 | 1 | 0.685 |
CDK16 |
0.787 | 0.577 | 1 | 0.856 |
HIPK1 |
0.787 | 0.524 | 1 | 0.868 |
SRPK1 |
0.782 | 0.291 | -3 | 0.629 |
ERK5 |
0.782 | 0.406 | 1 | 0.734 |
CDK10 |
0.781 | 0.534 | 1 | 0.862 |
CDK9 |
0.780 | 0.553 | 1 | 0.859 |
CDK14 |
0.779 | 0.564 | 1 | 0.852 |
MAK |
0.778 | 0.457 | -2 | 0.807 |
NLK |
0.776 | 0.513 | 1 | 0.730 |
JNK1 |
0.775 | 0.547 | 1 | 0.849 |
ERK2 |
0.772 | 0.545 | 1 | 0.865 |
HIPK3 |
0.772 | 0.486 | 1 | 0.841 |
DYRK1B |
0.771 | 0.495 | 1 | 0.870 |
DYRK1A |
0.770 | 0.442 | 1 | 0.822 |
COT |
0.768 | 0.075 | 2 | 0.770 |
CDKL5 |
0.767 | 0.204 | -3 | 0.669 |
MTOR |
0.766 | 0.181 | 1 | 0.557 |
ICK |
0.765 | 0.324 | -3 | 0.716 |
CDK6 |
0.765 | 0.534 | 1 | 0.855 |
CLK2 |
0.764 | 0.301 | -3 | 0.605 |
DYRK3 |
0.762 | 0.372 | 1 | 0.857 |
CDK4 |
0.761 | 0.536 | 1 | 0.861 |
MOK |
0.759 | 0.395 | 1 | 0.859 |
MOS |
0.758 | 0.093 | 1 | 0.487 |
CDKL1 |
0.757 | 0.134 | -3 | 0.674 |
SRPK2 |
0.757 | 0.188 | -3 | 0.542 |
CDC7 |
0.756 | 0.006 | 1 | 0.428 |
PRKD1 |
0.756 | 0.147 | -3 | 0.720 |
NDR2 |
0.756 | 0.127 | -3 | 0.727 |
PRP4 |
0.756 | 0.356 | -3 | 0.744 |
ERK7 |
0.755 | 0.278 | 2 | 0.581 |
PIM3 |
0.755 | 0.081 | -3 | 0.712 |
CDK2 |
0.755 | 0.373 | 1 | 0.806 |
SRPK3 |
0.752 | 0.171 | -3 | 0.594 |
MPSK1 |
0.751 | 0.253 | 1 | 0.526 |
GRK1 |
0.751 | 0.095 | -2 | 0.763 |
ATR |
0.751 | 0.038 | 1 | 0.498 |
PRPK |
0.750 | -0.003 | -1 | 0.675 |
CHAK2 |
0.750 | 0.054 | -1 | 0.665 |
SKMLCK |
0.750 | 0.054 | -2 | 0.811 |
CLK1 |
0.749 | 0.243 | -3 | 0.590 |
CLK4 |
0.748 | 0.217 | -3 | 0.616 |
RSK2 |
0.746 | 0.062 | -3 | 0.638 |
NEK6 |
0.746 | 0.002 | -2 | 0.789 |
MLK2 |
0.745 | 0.081 | 2 | 0.724 |
GSK3A |
0.744 | 0.198 | 4 | 0.436 |
P90RSK |
0.744 | 0.071 | -3 | 0.641 |
WNK1 |
0.744 | -0.032 | -2 | 0.845 |
IKKB |
0.743 | -0.086 | -2 | 0.698 |
PDHK4 |
0.743 | -0.130 | 1 | 0.484 |
TBK1 |
0.741 | -0.088 | 1 | 0.353 |
PIM1 |
0.741 | 0.055 | -3 | 0.647 |
RIPK3 |
0.741 | -0.069 | 3 | 0.663 |
GCN2 |
0.740 | -0.144 | 2 | 0.720 |
NUAK2 |
0.740 | 0.012 | -3 | 0.701 |
IKKA |
0.739 | 0.002 | -2 | 0.701 |
IKKE |
0.739 | -0.098 | 1 | 0.346 |
MLK3 |
0.739 | 0.045 | 2 | 0.666 |
PRKD2 |
0.739 | 0.031 | -3 | 0.644 |
MST4 |
0.739 | -0.029 | 2 | 0.790 |
BMPR2 |
0.739 | -0.163 | -2 | 0.811 |
GRK5 |
0.738 | -0.066 | -3 | 0.746 |
PKN3 |
0.738 | -0.001 | -3 | 0.688 |
RAF1 |
0.738 | -0.170 | 1 | 0.417 |
ULK2 |
0.738 | -0.123 | 2 | 0.679 |
GRK7 |
0.738 | 0.055 | 1 | 0.422 |
MASTL |
0.738 | -0.025 | -2 | 0.774 |
CAMK1B |
0.738 | -0.061 | -3 | 0.712 |
AURC |
0.737 | 0.037 | -2 | 0.566 |
MLK1 |
0.737 | -0.066 | 2 | 0.731 |
DSTYK |
0.737 | -0.120 | 2 | 0.803 |
RSK3 |
0.737 | 0.017 | -3 | 0.627 |
IRE1 |
0.737 | -0.017 | 1 | 0.482 |
NDR1 |
0.736 | -0.011 | -3 | 0.700 |
NIK |
0.736 | -0.045 | -3 | 0.740 |
PKCD |
0.736 | 0.022 | 2 | 0.690 |
PKN2 |
0.736 | -0.030 | -3 | 0.701 |
PKCZ |
0.735 | 0.035 | 2 | 0.709 |
CAMK2G |
0.735 | -0.111 | 2 | 0.705 |
DAPK2 |
0.735 | -0.026 | -3 | 0.732 |
PKCA |
0.735 | 0.057 | 2 | 0.656 |
PKCB |
0.735 | 0.034 | 2 | 0.665 |
LATS2 |
0.735 | 0.031 | -5 | 0.700 |
PDHK1 |
0.735 | -0.144 | 1 | 0.451 |
CAMLCK |
0.734 | -0.031 | -2 | 0.774 |
CAMK2D |
0.734 | -0.015 | -3 | 0.710 |
NEK7 |
0.733 | -0.139 | -3 | 0.778 |
NEK9 |
0.733 | -0.082 | 2 | 0.763 |
HUNK |
0.733 | -0.107 | 2 | 0.732 |
TGFBR2 |
0.732 | -0.059 | -2 | 0.710 |
RSK4 |
0.732 | 0.062 | -3 | 0.614 |
VRK2 |
0.732 | 0.136 | 1 | 0.544 |
LATS1 |
0.732 | 0.111 | -3 | 0.744 |
SMG1 |
0.732 | -0.034 | 1 | 0.478 |
PKCG |
0.731 | 0.016 | 2 | 0.661 |
BCKDK |
0.731 | -0.119 | -1 | 0.610 |
AMPKA1 |
0.731 | -0.042 | -3 | 0.721 |
PKR |
0.731 | 0.001 | 1 | 0.484 |
MAPKAPK3 |
0.731 | -0.028 | -3 | 0.646 |
DNAPK |
0.731 | -0.012 | 1 | 0.433 |
MARK4 |
0.730 | -0.046 | 4 | 0.707 |
BMPR1B |
0.730 | -0.014 | 1 | 0.399 |
MAPKAPK2 |
0.730 | 0.002 | -3 | 0.600 |
PKACG |
0.728 | -0.036 | -2 | 0.660 |
AMPKA2 |
0.728 | -0.022 | -3 | 0.685 |
TSSK1 |
0.728 | 0.007 | -3 | 0.746 |
MNK1 |
0.728 | 0.022 | -2 | 0.719 |
RIPK1 |
0.727 | -0.155 | 1 | 0.462 |
CAMK2A |
0.726 | 0.011 | 2 | 0.699 |
MNK2 |
0.726 | -0.035 | -2 | 0.715 |
CK1E |
0.726 | 0.022 | -3 | 0.527 |
TTBK2 |
0.726 | -0.111 | 2 | 0.647 |
ANKRD3 |
0.726 | -0.149 | 1 | 0.467 |
PAK1 |
0.726 | -0.044 | -2 | 0.728 |
PKACB |
0.725 | 0.016 | -2 | 0.585 |
TLK2 |
0.725 | -0.038 | 1 | 0.435 |
DLK |
0.725 | -0.167 | 1 | 0.429 |
P70S6KB |
0.725 | -0.040 | -3 | 0.644 |
GSK3B |
0.725 | 0.069 | 4 | 0.432 |
MLK4 |
0.724 | -0.038 | 2 | 0.640 |
ALK4 |
0.724 | -0.053 | -2 | 0.758 |
TGFBR1 |
0.724 | -0.040 | -2 | 0.731 |
IRE2 |
0.724 | -0.020 | 2 | 0.643 |
PHKG1 |
0.724 | -0.037 | -3 | 0.689 |
YSK4 |
0.724 | -0.068 | 1 | 0.379 |
AKT2 |
0.724 | 0.013 | -3 | 0.548 |
PASK |
0.724 | 0.096 | -3 | 0.751 |
MST3 |
0.724 | 0.015 | 2 | 0.785 |
ULK1 |
0.723 | -0.175 | -3 | 0.716 |
PAK3 |
0.723 | -0.064 | -2 | 0.721 |
GRK6 |
0.723 | -0.130 | 1 | 0.415 |
NEK2 |
0.723 | -0.070 | 2 | 0.752 |
SGK3 |
0.723 | -0.002 | -3 | 0.634 |
PAK6 |
0.722 | 0.006 | -2 | 0.627 |
TSSK2 |
0.721 | -0.049 | -5 | 0.811 |
PKG2 |
0.721 | -0.002 | -2 | 0.586 |
PIM2 |
0.721 | 0.031 | -3 | 0.597 |
NIM1 |
0.720 | -0.106 | 3 | 0.647 |
CK1D |
0.720 | 0.033 | -3 | 0.484 |
PKCH |
0.720 | -0.029 | 2 | 0.641 |
GRK4 |
0.720 | -0.145 | -2 | 0.770 |
CAMK2B |
0.720 | -0.047 | 2 | 0.678 |
ATM |
0.720 | -0.098 | 1 | 0.444 |
FAM20C |
0.719 | -0.048 | 2 | 0.509 |
WNK3 |
0.719 | -0.253 | 1 | 0.433 |
PRKD3 |
0.719 | -0.029 | -3 | 0.603 |
NEK5 |
0.718 | -0.042 | 1 | 0.464 |
QSK |
0.718 | -0.038 | 4 | 0.687 |
MSK1 |
0.718 | -0.019 | -3 | 0.618 |
MELK |
0.718 | -0.072 | -3 | 0.660 |
LKB1 |
0.717 | 0.038 | -3 | 0.761 |
MSK2 |
0.717 | -0.058 | -3 | 0.621 |
CHAK1 |
0.717 | -0.102 | 2 | 0.689 |
PINK1 |
0.717 | 0.028 | 1 | 0.632 |
NUAK1 |
0.716 | -0.050 | -3 | 0.631 |
PRKX |
0.716 | 0.009 | -3 | 0.550 |
MEK1 |
0.715 | -0.168 | 2 | 0.728 |
MEKK1 |
0.715 | -0.083 | 1 | 0.428 |
IRAK4 |
0.715 | -0.071 | 1 | 0.454 |
TAO3 |
0.714 | -0.030 | 1 | 0.430 |
PLK1 |
0.714 | -0.156 | -2 | 0.721 |
DCAMKL1 |
0.714 | -0.039 | -3 | 0.646 |
AURB |
0.714 | -0.036 | -2 | 0.562 |
WNK4 |
0.714 | -0.103 | -2 | 0.849 |
PERK |
0.713 | -0.095 | -2 | 0.756 |
CK1G1 |
0.713 | -0.011 | -3 | 0.503 |
GAK |
0.713 | 0.018 | 1 | 0.502 |
PLK4 |
0.713 | -0.108 | 2 | 0.523 |
ACVR2B |
0.712 | -0.100 | -2 | 0.719 |
CK1A2 |
0.712 | 0.001 | -3 | 0.480 |
CHK1 |
0.712 | -0.016 | -3 | 0.687 |
BUB1 |
0.711 | 0.097 | -5 | 0.745 |
GRK2 |
0.711 | -0.072 | -2 | 0.658 |
MEK5 |
0.711 | -0.147 | 2 | 0.718 |
MEKK2 |
0.711 | -0.096 | 2 | 0.703 |
QIK |
0.710 | -0.143 | -3 | 0.696 |
PAK2 |
0.710 | -0.102 | -2 | 0.709 |
ACVR2A |
0.710 | -0.104 | -2 | 0.696 |
PKCT |
0.710 | -0.038 | 2 | 0.643 |
DRAK1 |
0.710 | -0.122 | 1 | 0.399 |
ZAK |
0.710 | -0.130 | 1 | 0.390 |
CAMK4 |
0.710 | -0.154 | -3 | 0.666 |
PKCI |
0.710 | -0.024 | 2 | 0.684 |
PKCE |
0.709 | 0.004 | 2 | 0.656 |
GCK |
0.709 | -0.011 | 1 | 0.419 |
MAP3K15 |
0.709 | 0.000 | 1 | 0.400 |
PDK1 |
0.709 | -0.025 | 1 | 0.454 |
MYLK4 |
0.708 | -0.085 | -2 | 0.690 |
BRSK2 |
0.708 | -0.096 | -3 | 0.667 |
MARK3 |
0.708 | -0.068 | 4 | 0.628 |
ALK2 |
0.708 | -0.108 | -2 | 0.736 |
PLK3 |
0.708 | -0.138 | 2 | 0.671 |
PDHK3_TYR |
0.707 | 0.270 | 4 | 0.791 |
NEK11 |
0.707 | -0.118 | 1 | 0.428 |
AKT1 |
0.707 | -0.020 | -3 | 0.571 |
MEKK6 |
0.706 | -0.041 | 1 | 0.443 |
SIK |
0.706 | -0.085 | -3 | 0.605 |
PBK |
0.706 | 0.032 | 1 | 0.470 |
AKT3 |
0.705 | 0.016 | -3 | 0.506 |
BRSK1 |
0.705 | -0.089 | -3 | 0.646 |
LRRK2 |
0.704 | 0.001 | 2 | 0.771 |
KHS1 |
0.704 | 0.024 | 1 | 0.410 |
MEKK3 |
0.704 | -0.202 | 1 | 0.427 |
HRI |
0.704 | -0.190 | -2 | 0.768 |
TNIK |
0.703 | -0.013 | 3 | 0.748 |
CAMK1G |
0.703 | -0.097 | -3 | 0.603 |
HGK |
0.703 | -0.037 | 3 | 0.755 |
HPK1 |
0.703 | -0.053 | 1 | 0.414 |
AURA |
0.702 | -0.064 | -2 | 0.528 |
BRAF |
0.702 | -0.172 | -4 | 0.695 |
LIMK2_TYR |
0.702 | 0.207 | -3 | 0.777 |
PKACA |
0.702 | -0.026 | -2 | 0.527 |
PAK4 |
0.702 | -0.025 | -2 | 0.572 |
BMPR1A |
0.701 | -0.083 | 1 | 0.362 |
CAMKK2 |
0.701 | -0.097 | -2 | 0.699 |
TLK1 |
0.701 | -0.165 | -2 | 0.758 |
GRK3 |
0.701 | -0.063 | -2 | 0.621 |
EEF2K |
0.701 | -0.027 | 3 | 0.727 |
NEK4 |
0.701 | -0.108 | 1 | 0.419 |
KHS2 |
0.701 | 0.006 | 1 | 0.422 |
SMMLCK |
0.700 | -0.090 | -3 | 0.671 |
MINK |
0.700 | -0.078 | 1 | 0.401 |
TAO2 |
0.700 | -0.090 | 2 | 0.756 |
HASPIN |
0.700 | 0.021 | -1 | 0.582 |
NEK1 |
0.700 | -0.059 | 1 | 0.432 |
DCAMKL2 |
0.700 | -0.091 | -3 | 0.655 |
SSTK |
0.700 | -0.050 | 4 | 0.679 |
SGK1 |
0.700 | 0.004 | -3 | 0.481 |
PKMYT1_TYR |
0.700 | 0.185 | 3 | 0.751 |
VRK1 |
0.699 | -0.067 | 2 | 0.736 |
PAK5 |
0.699 | -0.054 | -2 | 0.575 |
CAMKK1 |
0.699 | -0.165 | -2 | 0.705 |
MARK2 |
0.699 | -0.109 | 4 | 0.590 |
PDHK4_TYR |
0.698 | 0.114 | 2 | 0.762 |
NEK8 |
0.698 | -0.159 | 2 | 0.735 |
SNRK |
0.698 | -0.194 | 2 | 0.574 |
ROCK2 |
0.697 | -0.002 | -3 | 0.649 |
MAPKAPK5 |
0.697 | -0.147 | -3 | 0.589 |
PKN1 |
0.697 | -0.035 | -3 | 0.578 |
CK2A2 |
0.697 | -0.063 | 1 | 0.342 |
TESK1_TYR |
0.696 | 0.102 | 3 | 0.762 |
TTBK1 |
0.696 | -0.153 | 2 | 0.557 |
P70S6K |
0.696 | -0.059 | -3 | 0.559 |
LOK |
0.695 | -0.060 | -2 | 0.703 |
SBK |
0.695 | 0.053 | -3 | 0.433 |
MAP2K4_TYR |
0.695 | 0.065 | -1 | 0.672 |
MST2 |
0.694 | -0.131 | 1 | 0.406 |
DAPK3 |
0.694 | -0.070 | -3 | 0.654 |
YSK1 |
0.693 | -0.057 | 2 | 0.748 |
TAK1 |
0.693 | -0.146 | 1 | 0.408 |
SLK |
0.693 | -0.056 | -2 | 0.662 |
PHKG2 |
0.693 | -0.121 | -3 | 0.635 |
MAP2K6_TYR |
0.692 | 0.027 | -1 | 0.676 |
STK33 |
0.692 | -0.116 | 2 | 0.530 |
MARK1 |
0.691 | -0.146 | 4 | 0.649 |
CK2A1 |
0.690 | -0.062 | 1 | 0.325 |
MRCKB |
0.690 | -0.043 | -3 | 0.583 |
DMPK1 |
0.690 | 0.006 | -3 | 0.606 |
PLK2 |
0.689 | -0.082 | -3 | 0.663 |
DAPK1 |
0.689 | -0.074 | -3 | 0.641 |
IRAK1 |
0.689 | -0.255 | -1 | 0.570 |
MAP2K7_TYR |
0.689 | -0.059 | 2 | 0.748 |
BMPR2_TYR |
0.688 | -0.031 | -1 | 0.663 |
PDHK1_TYR |
0.687 | -0.034 | -1 | 0.673 |
MYO3B |
0.687 | -0.012 | 2 | 0.752 |
AAK1 |
0.687 | 0.069 | 1 | 0.435 |
CAMK1D |
0.687 | -0.087 | -3 | 0.531 |
NEK3 |
0.686 | -0.091 | 1 | 0.422 |
OSR1 |
0.685 | -0.064 | 2 | 0.710 |
CK1A |
0.685 | -0.008 | -3 | 0.407 |
BIKE |
0.684 | -0.006 | 1 | 0.461 |
CRIK |
0.684 | 0.003 | -3 | 0.578 |
YANK3 |
0.684 | -0.033 | 2 | 0.357 |
MST1 |
0.684 | -0.154 | 1 | 0.396 |
CHK2 |
0.684 | -0.070 | -3 | 0.490 |
MRCKA |
0.683 | -0.061 | -3 | 0.597 |
TNK2 |
0.682 | 0.005 | 3 | 0.665 |
FGR |
0.682 | 0.008 | 1 | 0.461 |
LIMK1_TYR |
0.682 | -0.019 | 2 | 0.744 |
EPHA6 |
0.682 | -0.056 | -1 | 0.629 |
ASK1 |
0.681 | -0.072 | 1 | 0.385 |
RET |
0.680 | -0.105 | 1 | 0.446 |
PINK1_TYR |
0.680 | -0.187 | 1 | 0.490 |
CSF1R |
0.680 | -0.052 | 3 | 0.687 |
ABL2 |
0.679 | -0.054 | -1 | 0.583 |
MST1R |
0.679 | -0.093 | 3 | 0.710 |
EPHB4 |
0.679 | -0.081 | -1 | 0.603 |
JAK2 |
0.678 | -0.065 | 1 | 0.440 |
MEK2 |
0.678 | -0.215 | 2 | 0.702 |
TNNI3K_TYR |
0.678 | 0.037 | 1 | 0.479 |
CAMK1A |
0.678 | -0.072 | -3 | 0.507 |
TNK1 |
0.677 | 0.004 | 3 | 0.670 |
ROS1 |
0.677 | -0.051 | 3 | 0.657 |
TTK |
0.677 | -0.097 | -2 | 0.740 |
ABL1 |
0.677 | -0.062 | -1 | 0.577 |
ROCK1 |
0.676 | -0.055 | -3 | 0.599 |
TYK2 |
0.676 | -0.142 | 1 | 0.433 |
TXK |
0.676 | -0.036 | 1 | 0.411 |
YES1 |
0.676 | -0.062 | -1 | 0.664 |
JAK1 |
0.676 | -0.004 | 1 | 0.394 |
DDR1 |
0.676 | -0.110 | 4 | 0.714 |
LCK |
0.675 | -0.043 | -1 | 0.632 |
TYRO3 |
0.674 | -0.121 | 3 | 0.684 |
MYO3A |
0.674 | -0.094 | 1 | 0.432 |
BLK |
0.673 | -0.044 | -1 | 0.625 |
TAO1 |
0.672 | -0.107 | 1 | 0.378 |
HCK |
0.671 | -0.106 | -1 | 0.624 |
PKG1 |
0.671 | -0.081 | -2 | 0.501 |
JAK3 |
0.670 | -0.142 | 1 | 0.431 |
RIPK2 |
0.670 | -0.278 | 1 | 0.356 |
DDR2 |
0.669 | 0.009 | 3 | 0.646 |
WEE1_TYR |
0.669 | -0.064 | -1 | 0.571 |
FYN |
0.668 | -0.045 | -1 | 0.637 |
KDR |
0.668 | -0.093 | 3 | 0.649 |
KIT |
0.667 | -0.126 | 3 | 0.692 |
FGFR2 |
0.667 | -0.108 | 3 | 0.693 |
ITK |
0.667 | -0.119 | -1 | 0.589 |
SRMS |
0.666 | -0.143 | 1 | 0.413 |
FER |
0.666 | -0.171 | 1 | 0.442 |
MET |
0.666 | -0.098 | 3 | 0.679 |
EPHA4 |
0.666 | -0.106 | 2 | 0.679 |
NEK10_TYR |
0.666 | -0.112 | 1 | 0.367 |
EPHB1 |
0.663 | -0.160 | 1 | 0.416 |
EPHB3 |
0.663 | -0.138 | -1 | 0.590 |
INSRR |
0.663 | -0.164 | 3 | 0.637 |
BMX |
0.662 | -0.104 | -1 | 0.520 |
MERTK |
0.662 | -0.135 | 3 | 0.658 |
FGFR1 |
0.662 | -0.095 | 3 | 0.660 |
TEK |
0.661 | -0.088 | 3 | 0.622 |
PDGFRB |
0.660 | -0.203 | 3 | 0.692 |
AXL |
0.660 | -0.156 | 3 | 0.668 |
EPHB2 |
0.658 | -0.170 | -1 | 0.573 |
ALPHAK3 |
0.658 | -0.161 | -1 | 0.565 |
PTK6 |
0.658 | -0.165 | -1 | 0.553 |
EPHA7 |
0.657 | -0.120 | 2 | 0.675 |
LYN |
0.657 | -0.114 | 3 | 0.637 |
SRC |
0.657 | -0.090 | -1 | 0.629 |
FLT1 |
0.656 | -0.154 | -1 | 0.601 |
PDGFRA |
0.656 | -0.187 | 3 | 0.690 |
FGFR3 |
0.656 | -0.129 | 3 | 0.664 |
FLT3 |
0.656 | -0.221 | 3 | 0.679 |
TEC |
0.656 | -0.158 | -1 | 0.525 |
ALK |
0.655 | -0.139 | 3 | 0.620 |
PTK2B |
0.655 | -0.105 | -1 | 0.566 |
EPHA1 |
0.654 | -0.147 | 3 | 0.664 |
NTRK3 |
0.654 | -0.118 | -1 | 0.581 |
LTK |
0.654 | -0.151 | 3 | 0.648 |
BTK |
0.654 | -0.223 | -1 | 0.567 |
STLK3 |
0.654 | -0.207 | 1 | 0.359 |
PTK2 |
0.653 | -0.062 | -1 | 0.590 |
MATK |
0.653 | -0.115 | -1 | 0.525 |
FRK |
0.653 | -0.156 | -1 | 0.602 |
EPHA3 |
0.652 | -0.165 | 2 | 0.647 |
NTRK1 |
0.651 | -0.215 | -1 | 0.610 |
INSR |
0.651 | -0.165 | 3 | 0.629 |
YANK2 |
0.651 | -0.060 | 2 | 0.359 |
ERBB2 |
0.651 | -0.190 | 1 | 0.382 |
CK1G3 |
0.650 | -0.055 | -3 | 0.365 |
EGFR |
0.648 | -0.127 | 1 | 0.323 |
EPHA8 |
0.648 | -0.133 | -1 | 0.584 |
FLT4 |
0.647 | -0.205 | 3 | 0.655 |
SYK |
0.647 | -0.087 | -1 | 0.568 |
FGFR4 |
0.646 | -0.129 | -1 | 0.546 |
CSK |
0.645 | -0.159 | 2 | 0.677 |
NTRK2 |
0.645 | -0.236 | 3 | 0.639 |
EPHA5 |
0.644 | -0.175 | 2 | 0.651 |
ZAP70 |
0.641 | -0.047 | -1 | 0.518 |
ERBB4 |
0.640 | -0.101 | 1 | 0.337 |
MUSK |
0.640 | -0.148 | 1 | 0.339 |
EPHA2 |
0.638 | -0.141 | -1 | 0.540 |
CK1G2 |
0.635 | -0.053 | -3 | 0.438 |
IGF1R |
0.634 | -0.177 | 3 | 0.569 |
FES |
0.626 | -0.160 | -1 | 0.511 |