Motif 297 (n=117)
Position-wise Probabilities
Download
uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0J9YX86 | GOLGA8Q | S553 | ochoa | Golgin A8 family member Q | None |
A0A1B0GVZ6 | MBD3L2B | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2B | None |
A4D1S0 | KLRG2 | S212 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
A6NE82 | MBD3L3 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) | None |
A6NMD2 | GOLGA8J | S553 | ochoa | Golgin subfamily A member 8J | None |
A6NNZ2 | TUBB8B | S275 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
A7E2V4 | ZSWIM8 | S1089 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
H3BSY2 | GOLGA8M | S553 | ochoa | Golgin subfamily A member 8M | None |
H7C1W4 | None | S55 | ochoa | Uncharacterized protein | None |
I6L899 | GOLGA8R | S552 | ochoa | Golgin subfamily A member 8R | None |
K7ELQ4 | ATF7-NPFF | S171 | ochoa | ATF7-NPFF readthrough | None |
O00139 | KIF2A | S75 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
O14654 | IRS4 | S439 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
O15075 | DCLK1 | S334 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
O15119 | TBX3 | S432 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
O43683 | BUB1 | S593 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
O60239 | SH3BP5 | S351 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
O75161 | NPHP4 | S510 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
O75179 | ANKRD17 | S2042 | ochoa|psp | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
O75376 | NCOR1 | S1699 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O94967 | WDR47 | Y294 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
P04350 | TUBB4A | S275 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P04920 | SLC4A2 | S170 | ochoa | Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}. |
P07437 | TUBB | S275 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0CJ92 | GOLGA8H | S553 | ochoa | Golgin subfamily A member 8H | None |
P0DPH7 | TUBA3C | Y262 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0DPH8 | TUBA3D | Y262 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P16220 | CREB1 | S257 | psp | Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}. |
P24928 | POLR2A | S1508 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P27815 | PDE4A | S125 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
P35670 | ATP7B | S478 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
P35711 | SOX5 | S411 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
P35712 | SOX6 | S439 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
P36507 | MAP2K2 | S23 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
P36871 | PGM1 | S134 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
P49757 | NUMB | S241 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
P50613 | CDK7 | S161 | ochoa|psp | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
P51531 | SMARCA2 | S172 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P53367 | ARFIP1 | S76 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
P54646 | PRKAA2 | S173 | ochoa|psp | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
P58012 | FOXL2 | S323 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
P68363 | TUBA1B | Y262 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
P68366 | TUBA4A | Y262 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P68371 | TUBB4B | S275 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q03111 | MLLT1 | S152 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
Q03164 | KMT2A | S2164 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q07864 | POLE | S1201 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
Q0JRZ9 | FCHO2 | S493 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
Q0VDD7 | BRME1 | S367 | ochoa | Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}. |
Q13131 | PRKAA1 | S184 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
Q13153 | PAK1 | S220 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
Q13428 | TCOF1 | S1111 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q13885 | TUBB2A | S275 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14160 | SCRIB | S1306 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q15772 | SPEG | S19 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q18PE1 | DOK7 | S422 | ochoa | Protein Dok-7 (Downstream of tyrosine kinase 7) | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}. |
Q2TAL5 | SMTNL2 | S278 | ochoa | Smoothelin-like protein 2 | None |
Q3ZCM7 | TUBB8 | S275 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
Q4ZG55 | GREB1 | S317 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
Q53GS7 | GLE1 | S96 | ochoa | mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}. |
Q5R3F8 | ELFN2 | S644 | ochoa | Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
Q5T7P8 | SYT6 | S97 | ochoa | Synaptotagmin-6 (Synaptotagmin VI) (SytVI) | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}. |
Q5TGY3 | AHDC1 | S176 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
Q5THJ4 | VPS13D | S2689 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q68CZ2 | TNS3 | S687 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
Q6DKI7 | PVRIG | S207 | ochoa | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}. |
Q6F5E8 | CARMIL2 | S993 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
Q6JBY9 | RCSD1 | S105 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
Q6NV74 | CRACDL | S490 | ochoa | CRACD-like protein | None |
Q6P2E9 | EDC4 | S30 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6P3S6 | FBXO42 | S373 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
Q6PEY2 | TUBA3E | Y262 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q6WCQ1 | MPRIP | S362 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
Q6ZUM4 | ARHGAP27 | S84 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
Q6ZW31 | SYDE1 | S39 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
Q71U36 | TUBA1A | Y262 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q7L2J0 | MEPCE | S57 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
Q86VQ1 | GLCCI1 | S105 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
Q86YP4 | GATAD2A | S337 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
Q86YP4 | GATAD2A | S340 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
Q8IU81 | IRF2BP1 | S436 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
Q8IVF2 | AHNAK2 | S4894 | ochoa | Protein AHNAK2 | None |
Q8IVT2 | MISP | S281 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
Q8IX07 | ZFPM1 | S491 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Q8N0Y2 | ZNF444 | S232 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
Q8N3V7 | SYNPO | S232 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8NCD3 | HJURP | S182 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
Q8NFH5 | NUP35 | S22 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
Q8NHZ7 | MBD3L2 | S137 | ochoa | Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2) | May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}. |
Q8TEM1 | NUP210 | S1860 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
Q8WWI1 | LMO7 | S988 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q93075 | TATDN2 | S112 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
Q96EB6 | SIRT1 | S47 | ochoa|psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
Q96FS4 | SIPA1 | T64 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
Q99594 | TEAD3 | S145 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
Q99698 | LYST | S2089 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
Q99704 | DOK1 | S281 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
Q9BQE3 | TUBA1C | Y262 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9BRK4 | LZTS2 | S99 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
Q9BUF5 | TUBB6 | S275 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
Q9BVA1 | TUBB2B | S275 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9BWE0 | REPIN1 | S24 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
Q9HBH9 | MKNK2 | S437 | ochoa|psp | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
Q9NRR5 | UBQLN4 | T111 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
Q9NY65 | TUBA8 | Y262 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9NYB9 | ABI2 | S224 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
Q9NZJ0 | DTL | S441 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
Q9NZJ0 | DTL | S676 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
Q9P0K8 | FOXJ2 | S43 | ochoa | Forkhead box protein J2 (Fork head homologous X) | [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}. |
Q9P107 | GMIP | S231 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P1Y5 | CAMSAP3 | S544 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9ULH1 | ASAP1 | S782 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9UMN6 | KMT2B | S1887 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q9UNF1 | MAGED2 | S244 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
Q9Y2H5 | PLEKHA6 | S276 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y2H5 | PLEKHA6 | S1021 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y4F5 | CEP170B | S1545 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.110223e-16 | 15.955 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.110223e-16 | 15.955 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.110223e-16 | 15.955 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.110223e-16 | 15.955 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.110223e-16 | 15.955 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.110223e-16 | 15.955 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.110223e-16 | 15.955 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.110223e-16 | 15.955 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.110223e-16 | 15.955 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.110223e-16 | 15.955 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.110223e-16 | 15.955 |
R-HSA-438064 | Post NMDA receptor activation events | 1.110223e-16 | 15.955 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.110223e-16 | 15.955 |
R-HSA-9646399 | Aggrephagy | 1.110223e-16 | 15.955 |
R-HSA-437239 | Recycling pathway of L1 | 1.110223e-16 | 15.955 |
R-HSA-983189 | Kinesins | 1.110223e-16 | 15.955 |
R-HSA-190861 | Gap junction assembly | 1.110223e-16 | 15.955 |
R-HSA-190828 | Gap junction trafficking | 1.110223e-16 | 15.955 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.110223e-16 | 15.955 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.110223e-16 | 15.955 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.110223e-16 | 15.955 |
R-HSA-157858 | Gap junction trafficking and regulation | 1.110223e-16 | 15.955 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.110223e-16 | 15.955 |
R-HSA-9663891 | Selective autophagy | 1.110223e-16 | 15.955 |
R-HSA-373760 | L1CAM interactions | 1.110223e-16 | 15.955 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.110223e-16 | 15.955 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.440892e-16 | 15.353 |
R-HSA-9833482 | PKR-mediated signaling | 5.551115e-16 | 15.256 |
R-HSA-68877 | Mitotic Prometaphase | 6.661338e-15 | 14.176 |
R-HSA-2467813 | Separation of Sister Chromatids | 6.883383e-15 | 14.162 |
R-HSA-9609690 | HCMV Early Events | 8.437695e-15 | 14.074 |
R-HSA-6807878 | COPI-mediated anterograde transport | 9.880985e-15 | 14.005 |
R-HSA-1632852 | Macroautophagy | 1.054712e-14 | 13.977 |
R-HSA-2132295 | MHC class II antigen presentation | 1.953993e-14 | 13.709 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.241851e-14 | 13.489 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.107825e-14 | 13.386 |
R-HSA-68882 | Mitotic Anaphase | 4.363176e-14 | 13.360 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.707346e-14 | 13.327 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.273559e-14 | 13.278 |
R-HSA-69275 | G2/M Transition | 5.062617e-14 | 13.296 |
R-HSA-9612973 | Autophagy | 4.929390e-14 | 13.307 |
R-HSA-453274 | Mitotic G2-G2/M phases | 5.950795e-14 | 13.225 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.272760e-14 | 13.203 |
R-HSA-5617833 | Cilium Assembly | 6.983303e-14 | 13.156 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.761125e-13 | 12.559 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 2.832179e-13 | 12.548 |
R-HSA-9609646 | HCMV Infection | 4.545253e-13 | 12.342 |
R-HSA-390466 | Chaperonin-mediated protein folding | 9.889867e-13 | 12.005 |
R-HSA-5620924 | Intraflagellar transport | 1.159850e-12 | 11.936 |
R-HSA-391251 | Protein folding | 2.092215e-12 | 11.679 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 4.527823e-12 | 11.344 |
R-HSA-68886 | M Phase | 6.776579e-12 | 11.169 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.103562e-11 | 10.677 |
R-HSA-112315 | Transmission across Chemical Synapses | 2.700284e-11 | 10.569 |
R-HSA-69278 | Cell Cycle, Mitotic | 2.702993e-11 | 10.568 |
R-HSA-5610787 | Hedgehog 'off' state | 9.870260e-11 | 10.006 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.528233e-10 | 9.597 |
R-HSA-5358351 | Signaling by Hedgehog | 3.419981e-10 | 9.466 |
R-HSA-1640170 | Cell Cycle | 3.838225e-10 | 9.416 |
R-HSA-422475 | Axon guidance | 3.039120e-09 | 8.517 |
R-HSA-112316 | Neuronal System | 9.001308e-09 | 8.046 |
R-HSA-9675108 | Nervous system development | 9.090694e-09 | 8.041 |
R-HSA-913531 | Interferon Signaling | 1.874576e-08 | 7.727 |
R-HSA-446203 | Asparagine N-linked glycosylation | 2.039304e-06 | 5.691 |
R-HSA-199991 | Membrane Trafficking | 4.574512e-06 | 5.340 |
R-HSA-2262752 | Cellular responses to stress | 4.958411e-06 | 5.305 |
R-HSA-162582 | Signal Transduction | 5.567452e-06 | 5.254 |
R-HSA-1280218 | Adaptive Immune System | 7.647308e-06 | 5.116 |
R-HSA-9824446 | Viral Infection Pathways | 2.453726e-05 | 4.610 |
R-HSA-8953897 | Cellular responses to stimuli | 3.127728e-05 | 4.505 |
R-HSA-109582 | Hemostasis | 5.311036e-05 | 4.275 |
R-HSA-5653656 | Vesicle-mediated transport | 7.714440e-05 | 4.113 |
R-HSA-1266738 | Developmental Biology | 8.385829e-05 | 4.076 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.356416e-04 | 3.868 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.519770e-04 | 3.599 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.519770e-04 | 3.599 |
R-HSA-8854518 | AURKA Activation by TPX2 | 3.042394e-04 | 3.517 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.579313e-04 | 3.339 |
R-HSA-380287 | Centrosome maturation | 5.110126e-04 | 3.292 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 7.284284e-04 | 3.138 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.090899e-04 | 3.092 |
R-HSA-5663205 | Infectious disease | 1.415850e-03 | 2.849 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 2.050021e-03 | 2.688 |
R-HSA-9022707 | MECP2 regulates transcription factors | 2.840785e-03 | 2.547 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.714852e-03 | 2.243 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.172918e-02 | 1.931 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.225709e-02 | 1.912 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.392179e-02 | 1.856 |
R-HSA-6782135 | Dual incision in TC-NER | 1.509951e-02 | 1.821 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 1.696873e-02 | 1.770 |
R-HSA-9707616 | Heme signaling | 1.761929e-02 | 1.754 |
R-HSA-445144 | Signal transduction by L1 | 1.646237e-02 | 1.784 |
R-HSA-212165 | Epigenetic regulation of gene expression | 1.802113e-02 | 1.744 |
R-HSA-597592 | Post-translational protein modification | 1.929320e-02 | 1.715 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.171229e-02 | 1.663 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.171229e-02 | 1.663 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.181258e-02 | 1.661 |
R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 2.302064e-02 | 1.638 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.311957e-02 | 1.636 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.409605e-02 | 1.618 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.488489e-02 | 1.604 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.568758e-02 | 1.590 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.604334e-02 | 1.584 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.650408e-02 | 1.577 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.910848e-02 | 1.536 |
R-HSA-113418 | Formation of the Early Elongation Complex | 2.910848e-02 | 1.536 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.231001e-02 | 1.491 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.396040e-02 | 1.469 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.396040e-02 | 1.469 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.733440e-02 | 1.563 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.353185e-02 | 1.475 |
R-HSA-72086 | mRNA Capping | 3.069250e-02 | 1.513 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.231001e-02 | 1.491 |
R-HSA-9909396 | Circadian clock | 2.881835e-02 | 1.540 |
R-HSA-9018519 | Estrogen-dependent gene expression | 3.197309e-02 | 1.495 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.587246e-02 | 1.445 |
R-HSA-9652169 | Signaling by MAP2K mutants | 4.551548e-02 | 1.342 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.735744e-02 | 1.428 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.735744e-02 | 1.428 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.910292e-02 | 1.408 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.268494e-02 | 1.370 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.737365e-02 | 1.427 |
R-HSA-141424 | Amplification of signal from the kinetochores | 3.737365e-02 | 1.427 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 3.671833e-02 | 1.435 |
R-HSA-8875513 | MET interacts with TNS proteins | 3.807488e-02 | 1.419 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.638459e-02 | 1.334 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.268494e-02 | 1.370 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.735744e-02 | 1.428 |
R-HSA-162587 | HIV Life Cycle | 4.818605e-02 | 1.317 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.910292e-02 | 1.408 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.735744e-02 | 1.428 |
R-HSA-180746 | Nuclear import of Rev protein | 4.087894e-02 | 1.389 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.575063e-02 | 1.340 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.827715e-02 | 1.316 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.354448e-02 | 1.361 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.353998e-02 | 1.361 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.735744e-02 | 1.428 |
R-HSA-9856651 | MITF-M-dependent gene expression | 4.261369e-02 | 1.370 |
R-HSA-168256 | Immune System | 3.630309e-02 | 1.440 |
R-HSA-3247509 | Chromatin modifying enzymes | 4.872119e-02 | 1.312 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.019747e-02 | 1.299 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.019747e-02 | 1.299 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.019747e-02 | 1.299 |
R-HSA-8939211 | ESR-mediated signaling | 5.075261e-02 | 1.295 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.214502e-02 | 1.283 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.214502e-02 | 1.283 |
R-HSA-167169 | HIV Transcription Elongation | 5.214502e-02 | 1.283 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.214502e-02 | 1.283 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.214502e-02 | 1.283 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.214502e-02 | 1.283 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.214502e-02 | 1.283 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.411928e-02 | 1.267 |
R-HSA-3214841 | PKMTs methylate histone lysines | 5.411928e-02 | 1.267 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 6.022581e-02 | 1.220 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 6.749642e-02 | 1.171 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.611971e-02 | 1.251 |
R-HSA-167161 | HIV Transcription Initiation | 5.611971e-02 | 1.251 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.611971e-02 | 1.251 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.019706e-02 | 1.220 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.437302e-02 | 1.191 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.649674e-02 | 1.177 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 5.607141e-02 | 1.251 |
R-HSA-199920 | CREB phosphorylation | 6.749642e-02 | 1.171 |
R-HSA-5696398 | Nucleotide Excision Repair | 6.355278e-02 | 1.197 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.437302e-02 | 1.191 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 6.022581e-02 | 1.220 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.814581e-02 | 1.235 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.851566e-02 | 1.233 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.437302e-02 | 1.191 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 8.187065e-02 | 1.087 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.649674e-02 | 1.177 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 7.970929e-02 | 1.098 |
R-HSA-165159 | MTOR signalling | 5.814581e-02 | 1.235 |
R-HSA-73893 | DNA Damage Bypass | 7.300508e-02 | 1.137 |
R-HSA-4839726 | Chromatin organization | 5.937141e-02 | 1.226 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.187065e-02 | 1.087 |
R-HSA-211000 | Gene Silencing by RNA | 6.614451e-02 | 1.180 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 7.880430e-02 | 1.103 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.236426e-02 | 1.205 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.476326e-02 | 1.189 |
R-HSA-1592230 | Mitochondrial biogenesis | 8.268092e-02 | 1.083 |
R-HSA-3214815 | HDACs deacetylate histones | 8.659707e-02 | 1.062 |
R-HSA-3371556 | Cellular response to heat stress | 8.855316e-02 | 1.053 |
R-HSA-112411 | MAPK1 (ERK2) activation | 8.897512e-02 | 1.051 |
R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 8.897512e-02 | 1.051 |
R-HSA-9613354 | Lipophagy | 8.897512e-02 | 1.051 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 8.897512e-02 | 1.051 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 9.128505e-02 | 1.040 |
R-HSA-389948 | Co-inhibition by PD-1 | 9.185179e-02 | 1.037 |
R-HSA-68952 | DNA replication initiation | 9.602505e-02 | 1.018 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 9.602505e-02 | 1.018 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 9.602505e-02 | 1.018 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 9.602505e-02 | 1.018 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 9.602505e-02 | 1.018 |
R-HSA-191859 | snRNP Assembly | 9.604595e-02 | 1.018 |
R-HSA-194441 | Metabolism of non-coding RNA | 9.604595e-02 | 1.018 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 9.845270e-02 | 1.007 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.099630e-01 | 0.959 |
R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.505103e-01 | 0.822 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.505103e-01 | 0.822 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.636146e-01 | 0.786 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.700914e-01 | 0.769 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.765184e-01 | 0.753 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.828960e-01 | 0.738 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.892246e-01 | 0.723 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.892246e-01 | 0.723 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.892246e-01 | 0.723 |
R-HSA-6803529 | FGFR2 alternative splicing | 1.955046e-01 | 0.709 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.107334e-01 | 0.956 |
R-HSA-167172 | Transcription of the HIV genome | 1.182854e-01 | 0.927 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.686426e-01 | 0.773 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.765184e-01 | 0.753 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.505103e-01 | 0.822 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.505103e-01 | 0.822 |
R-HSA-6802957 | Oncogenic MAPK signaling | 1.631733e-01 | 0.787 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.236877e-01 | 0.908 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.372024e-01 | 0.863 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.700914e-01 | 0.769 |
R-HSA-350054 | Notch-HLH transcription pathway | 1.955046e-01 | 0.709 |
R-HSA-73864 | RNA Polymerase I Transcription | 1.443102e-01 | 0.841 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.017363e-01 | 0.695 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.496518e-01 | 0.825 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.390106e-01 | 0.857 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.099630e-01 | 0.959 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.304711e-01 | 0.884 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.505103e-01 | 0.822 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.604511e-01 | 0.795 |
R-HSA-162906 | HIV Infection | 1.268246e-01 | 0.897 |
R-HSA-170968 | Frs2-mediated activation | 1.236877e-01 | 0.908 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.604511e-01 | 0.795 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.828960e-01 | 0.738 |
R-HSA-3928664 | Ephrin signaling | 1.636146e-01 | 0.786 |
R-HSA-425381 | Bicarbonate transporters | 1.030209e-01 | 0.987 |
R-HSA-428540 | Activation of RAC1 | 1.099630e-01 | 0.959 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.892246e-01 | 0.723 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.955046e-01 | 0.709 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.168518e-01 | 0.932 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.168518e-01 | 0.932 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.132362e-01 | 0.946 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.520417e-01 | 0.818 |
R-HSA-169893 | Prolonged ERK activation events | 1.438820e-01 | 0.842 |
R-HSA-9005895 | Pervasive developmental disorders | 1.168518e-01 | 0.932 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.168518e-01 | 0.932 |
R-HSA-9697154 | Disorders of Nervous System Development | 1.168518e-01 | 0.932 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.304711e-01 | 0.884 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.443102e-01 | 0.841 |
R-HSA-389359 | CD28 dependent Vav1 pathway | 1.236877e-01 | 0.908 |
R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.236877e-01 | 0.908 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.304711e-01 | 0.884 |
R-HSA-9675151 | Disorders of Developmental Biology | 1.505103e-01 | 0.822 |
R-HSA-70370 | Galactose catabolism | 1.505103e-01 | 0.822 |
R-HSA-392517 | Rap1 signalling | 1.700914e-01 | 0.769 |
R-HSA-6784531 | tRNA processing in the nucleus | 1.033168e-01 | 0.986 |
R-HSA-5632684 | Hedgehog 'on' state | 1.259627e-01 | 0.900 |
R-HSA-5635838 | Activation of SMO | 1.438820e-01 | 0.842 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.700914e-01 | 0.769 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.033168e-01 | 0.986 |
R-HSA-168255 | Influenza Infection | 1.997578e-01 | 0.699 |
R-HSA-200425 | Carnitine shuttle | 2.017363e-01 | 0.695 |
R-HSA-1980143 | Signaling by NOTCH1 | 1.390106e-01 | 0.857 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.233903e-01 | 0.909 |
R-HSA-1169408 | ISG15 antiviral mechanism | 1.363774e-01 | 0.865 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.523376e-01 | 0.817 |
R-HSA-1643685 | Disease | 1.074258e-01 | 0.969 |
R-HSA-9690406 | Transcriptional regulation of testis differentiation | 1.505103e-01 | 0.822 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.017363e-01 | 0.695 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 1.570877e-01 | 0.804 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.210453e-01 | 0.917 |
R-HSA-3322077 | Glycogen synthesis | 1.765184e-01 | 0.753 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.659039e-01 | 0.780 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.686426e-01 | 0.773 |
R-HSA-2028269 | Signaling by Hippo | 1.570877e-01 | 0.804 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 1.686426e-01 | 0.773 |
R-HSA-5633007 | Regulation of TP53 Activity | 1.612752e-01 | 0.792 |
R-HSA-381070 | IRE1alpha activates chaperones | 1.852287e-01 | 0.732 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.036201e-01 | 0.691 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.079201e-01 | 0.682 |
R-HSA-70171 | Glycolysis | 2.133395e-01 | 0.671 |
R-HSA-9620244 | Long-term potentiation | 2.140565e-01 | 0.669 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.140565e-01 | 0.669 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.140565e-01 | 0.669 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.140565e-01 | 0.669 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.140565e-01 | 0.669 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.140565e-01 | 0.669 |
R-HSA-9842860 | Regulation of endogenous retroelements | 2.190140e-01 | 0.660 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.201456e-01 | 0.657 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.201456e-01 | 0.657 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.201456e-01 | 0.657 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.201456e-01 | 0.657 |
R-HSA-111885 | Opioid Signalling | 2.247016e-01 | 0.648 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.261880e-01 | 0.646 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.261880e-01 | 0.646 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.261880e-01 | 0.646 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 2.275498e-01 | 0.643 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.275498e-01 | 0.643 |
R-HSA-167287 | HIV elongation arrest and recovery | 2.321839e-01 | 0.634 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 2.321839e-01 | 0.634 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.381273e-01 | 0.623 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 2.381337e-01 | 0.623 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.381337e-01 | 0.623 |
R-HSA-180024 | DARPP-32 events | 2.381337e-01 | 0.623 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.440378e-01 | 0.613 |
R-HSA-68962 | Activation of the pre-replicative complex | 2.440378e-01 | 0.613 |
R-HSA-1483249 | Inositol phosphate metabolism | 2.504134e-01 | 0.601 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.557101e-01 | 0.592 |
R-HSA-397795 | G-protein beta:gamma signalling | 2.614791e-01 | 0.583 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.614791e-01 | 0.583 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.614791e-01 | 0.583 |
R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 2.614791e-01 | 0.583 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.618767e-01 | 0.582 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.647438e-01 | 0.577 |
R-HSA-70326 | Glucose metabolism | 2.704782e-01 | 0.568 |
R-HSA-5696400 | Dual Incision in GG-NER | 2.728842e-01 | 0.564 |
R-HSA-1980145 | Signaling by NOTCH2 | 2.728842e-01 | 0.564 |
R-HSA-5673000 | RAF activation | 2.728842e-01 | 0.564 |
R-HSA-187687 | Signalling to ERKs | 2.785211e-01 | 0.555 |
R-HSA-68875 | Mitotic Prophase | 2.790780e-01 | 0.554 |
R-HSA-73886 | Chromosome Maintenance | 2.819434e-01 | 0.550 |
R-HSA-111933 | Calmodulin induced events | 2.841146e-01 | 0.547 |
R-HSA-111997 | CaM pathway | 2.841146e-01 | 0.547 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 2.841146e-01 | 0.547 |
R-HSA-8853659 | RET signaling | 2.841146e-01 | 0.547 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.896651e-01 | 0.538 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.896651e-01 | 0.538 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.896651e-01 | 0.538 |
R-HSA-162909 | Host Interactions of HIV factors | 2.905340e-01 | 0.537 |
R-HSA-8875878 | MET promotes cell motility | 2.951729e-01 | 0.530 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.951729e-01 | 0.530 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.962548e-01 | 0.528 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.962548e-01 | 0.528 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.962548e-01 | 0.528 |
R-HSA-194138 | Signaling by VEGF | 2.962548e-01 | 0.528 |
R-HSA-69206 | G1/S Transition | 2.962548e-01 | 0.528 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.006384e-01 | 0.522 |
R-HSA-114608 | Platelet degranulation | 3.019691e-01 | 0.520 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.048235e-01 | 0.516 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.060618e-01 | 0.514 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.060618e-01 | 0.514 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.060618e-01 | 0.514 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.060618e-01 | 0.514 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.060618e-01 | 0.514 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.060618e-01 | 0.514 |
R-HSA-202433 | Generation of second messenger molecules | 3.060618e-01 | 0.514 |
R-HSA-8982491 | Glycogen metabolism | 3.060618e-01 | 0.514 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.114434e-01 | 0.507 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.114434e-01 | 0.507 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.114434e-01 | 0.507 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.114434e-01 | 0.507 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.114434e-01 | 0.507 |
R-HSA-9843745 | Adipogenesis | 3.162194e-01 | 0.500 |
R-HSA-5674135 | MAP2K and MAPK activation | 3.167837e-01 | 0.499 |
R-HSA-9656223 | Signaling by RAF1 mutants | 3.167837e-01 | 0.499 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.167837e-01 | 0.499 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 3.167837e-01 | 0.499 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.219024e-01 | 0.492 |
R-HSA-111996 | Ca-dependent events | 3.220829e-01 | 0.492 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.261353e-01 | 0.487 |
R-HSA-157118 | Signaling by NOTCH | 3.282997e-01 | 0.484 |
R-HSA-392499 | Metabolism of proteins | 3.324956e-01 | 0.478 |
R-HSA-3214858 | RMTs methylate histone arginines | 3.325592e-01 | 0.478 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.325592e-01 | 0.478 |
R-HSA-69231 | Cyclin D associated events in G1 | 3.325592e-01 | 0.478 |
R-HSA-69236 | G1 Phase | 3.325592e-01 | 0.478 |
R-HSA-212436 | Generic Transcription Pathway | 3.363016e-01 | 0.473 |
R-HSA-774815 | Nucleosome assembly | 3.377370e-01 | 0.471 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.377370e-01 | 0.471 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.377370e-01 | 0.471 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.377370e-01 | 0.471 |
R-HSA-1489509 | DAG and IP3 signaling | 3.377370e-01 | 0.471 |
R-HSA-73894 | DNA Repair | 3.413681e-01 | 0.467 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 3.416973e-01 | 0.466 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.428750e-01 | 0.465 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 3.428750e-01 | 0.465 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.428750e-01 | 0.465 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.428750e-01 | 0.465 |
R-HSA-6802949 | Signaling by RAS mutants | 3.428750e-01 | 0.465 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.473217e-01 | 0.459 |
R-HSA-73857 | RNA Polymerase II Transcription | 3.528787e-01 | 0.452 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.529305e-01 | 0.452 |
R-HSA-9031628 | NGF-stimulated transcription | 3.530325e-01 | 0.452 |
R-HSA-389356 | Co-stimulation by CD28 | 3.530325e-01 | 0.452 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.580527e-01 | 0.446 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 3.630343e-01 | 0.440 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.640981e-01 | 0.439 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.663649e-01 | 0.436 |
R-HSA-166520 | Signaling by NTRKs | 3.696553e-01 | 0.432 |
R-HSA-69242 | S Phase | 3.696553e-01 | 0.432 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.728826e-01 | 0.428 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.728826e-01 | 0.428 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.728826e-01 | 0.428 |
R-HSA-9679191 | Potential therapeutics for SARS | 3.751937e-01 | 0.426 |
R-HSA-74160 | Gene expression (Transcription) | 3.755417e-01 | 0.425 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.777500e-01 | 0.423 |
R-HSA-445355 | Smooth Muscle Contraction | 3.777500e-01 | 0.423 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.873727e-01 | 0.412 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.921285e-01 | 0.407 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.921285e-01 | 0.407 |
R-HSA-9610379 | HCMV Late Events | 3.944196e-01 | 0.404 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.015305e-01 | 0.396 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.061773e-01 | 0.391 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 4.107882e-01 | 0.386 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.107882e-01 | 0.386 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.107882e-01 | 0.386 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.107882e-01 | 0.386 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.107882e-01 | 0.386 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.107882e-01 | 0.386 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.107882e-01 | 0.386 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.153637e-01 | 0.382 |
R-HSA-450294 | MAP kinase activation | 4.153637e-01 | 0.382 |
R-HSA-112043 | PLC beta mediated events | 4.153637e-01 | 0.382 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.199039e-01 | 0.377 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 4.199039e-01 | 0.377 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.199039e-01 | 0.377 |
R-HSA-5619102 | SLC transporter disorders | 4.214137e-01 | 0.375 |
R-HSA-373755 | Semaphorin interactions | 4.244091e-01 | 0.372 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.244091e-01 | 0.372 |
R-HSA-8848021 | Signaling by PTK6 | 4.244091e-01 | 0.372 |
R-HSA-2428924 | IGF1R signaling cascade | 4.288796e-01 | 0.368 |
R-HSA-936837 | Ion transport by P-type ATPases | 4.288796e-01 | 0.368 |
R-HSA-72306 | tRNA processing | 4.320417e-01 | 0.364 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.333157e-01 | 0.363 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.399453e-01 | 0.357 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.399453e-01 | 0.357 |
R-HSA-112040 | G-protein mediated events | 4.420856e-01 | 0.354 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.420856e-01 | 0.354 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.425666e-01 | 0.354 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.549885e-01 | 0.342 |
R-HSA-448424 | Interleukin-17 signaling | 4.549885e-01 | 0.342 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.549885e-01 | 0.342 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.592234e-01 | 0.338 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.592234e-01 | 0.338 |
R-HSA-453276 | Regulation of mitotic cell cycle | 4.592234e-01 | 0.338 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.592234e-01 | 0.338 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.634256e-01 | 0.334 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.634256e-01 | 0.334 |
R-HSA-1236394 | Signaling by ERBB4 | 4.717331e-01 | 0.326 |
R-HSA-1226099 | Signaling by FGFR in disease | 4.717331e-01 | 0.326 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.839556e-01 | 0.315 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 4.879671e-01 | 0.312 |
R-HSA-4086400 | PCP/CE pathway | 4.879671e-01 | 0.312 |
R-HSA-5654738 | Signaling by FGFR2 | 4.958976e-01 | 0.305 |
R-HSA-6806834 | Signaling by MET | 4.958976e-01 | 0.305 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.984622e-01 | 0.302 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 5.075654e-01 | 0.295 |
R-HSA-6798695 | Neutrophil degranulation | 5.102644e-01 | 0.292 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.151947e-01 | 0.288 |
R-HSA-376176 | Signaling by ROBO receptors | 5.154943e-01 | 0.288 |
R-HSA-73884 | Base Excision Repair | 5.373861e-01 | 0.270 |
R-HSA-5683057 | MAPK family signaling cascades | 5.444092e-01 | 0.264 |
R-HSA-2682334 | EPH-Ephrin signaling | 5.481008e-01 | 0.261 |
R-HSA-418990 | Adherens junctions interactions | 5.529789e-01 | 0.257 |
R-HSA-8951664 | Neddylation | 5.597785e-01 | 0.252 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.654144e-01 | 0.248 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.687973e-01 | 0.245 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.687973e-01 | 0.245 |
R-HSA-157579 | Telomere Maintenance | 5.687973e-01 | 0.245 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.721541e-01 | 0.242 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.721541e-01 | 0.242 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.721541e-01 | 0.242 |
R-HSA-190236 | Signaling by FGFR | 5.721541e-01 | 0.242 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 5.753595e-01 | 0.240 |
R-HSA-9614085 | FOXO-mediated transcription | 5.754850e-01 | 0.240 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.820698e-01 | 0.235 |
R-HSA-1483255 | PI Metabolism | 5.853240e-01 | 0.233 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.917574e-01 | 0.228 |
R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 5.949368e-01 | 0.226 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.980917e-01 | 0.223 |
R-HSA-69239 | Synthesis of DNA | 6.043285e-01 | 0.219 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.043285e-01 | 0.219 |
R-HSA-9700206 | Signaling by ALK in cancer | 6.043285e-01 | 0.219 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.074108e-01 | 0.217 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.074108e-01 | 0.217 |
R-HSA-69002 | DNA Replication Pre-Initiation | 6.104693e-01 | 0.214 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.104693e-01 | 0.214 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.135042e-01 | 0.212 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 6.135042e-01 | 0.212 |
R-HSA-202403 | TCR signaling | 6.135042e-01 | 0.212 |
R-HSA-5619115 | Disorders of transmembrane transporters | 6.156258e-01 | 0.211 |
R-HSA-2871796 | FCERI mediated MAPK activation | 6.195037e-01 | 0.208 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.224687e-01 | 0.206 |
R-HSA-421270 | Cell-cell junction organization | 6.237251e-01 | 0.205 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.254108e-01 | 0.204 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.312269e-01 | 0.200 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.425917e-01 | 0.192 |
R-HSA-5693538 | Homology Directed Repair | 6.425917e-01 | 0.192 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.453782e-01 | 0.190 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.453782e-01 | 0.190 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.508867e-01 | 0.186 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.536090e-01 | 0.185 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.536090e-01 | 0.185 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.563103e-01 | 0.183 |
R-HSA-9711123 | Cellular response to chemical stress | 6.566898e-01 | 0.183 |
R-HSA-9679506 | SARS-CoV Infections | 6.573927e-01 | 0.182 |
R-HSA-8953854 | Metabolism of RNA | 6.579673e-01 | 0.182 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.669080e-01 | 0.176 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 6.677664e-01 | 0.175 |
R-HSA-446728 | Cell junction organization | 6.749911e-01 | 0.171 |
R-HSA-9658195 | Leishmania infection | 6.803264e-01 | 0.167 |
R-HSA-9824443 | Parasitic Infection Pathways | 6.803264e-01 | 0.167 |
R-HSA-5673001 | RAF/MAP kinase cascade | 6.942081e-01 | 0.159 |
R-HSA-163685 | Integration of energy metabolism | 6.967947e-01 | 0.157 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.967947e-01 | 0.157 |
R-HSA-6807070 | PTEN Regulation | 7.038408e-01 | 0.153 |
R-HSA-1257604 | PIP3 activates AKT signaling | 7.042932e-01 | 0.152 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.059471e-01 | 0.151 |
R-HSA-9664407 | Parasite infection | 7.061533e-01 | 0.151 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.061533e-01 | 0.151 |
R-HSA-9664417 | Leishmania phagocytosis | 7.061533e-01 | 0.151 |
R-HSA-195721 | Signaling by WNT | 7.092322e-01 | 0.149 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 7.152252e-01 | 0.146 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.180222e-01 | 0.144 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.261754e-01 | 0.139 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.325439e-01 | 0.135 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.346339e-01 | 0.134 |
R-HSA-69306 | DNA Replication | 7.367077e-01 | 0.133 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 7.367077e-01 | 0.133 |
R-HSA-1500931 | Cell-Cell communication | 7.374481e-01 | 0.132 |
R-HSA-1989781 | PPARA activates gene expression | 7.408072e-01 | 0.130 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.448434e-01 | 0.128 |
R-HSA-9006936 | Signaling by TGFB family members | 7.507811e-01 | 0.124 |
R-HSA-418555 | G alpha (s) signalling events | 7.731918e-01 | 0.112 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.731918e-01 | 0.112 |
R-HSA-9006925 | Intracellular signaling by second messengers | 7.740959e-01 | 0.111 |
R-HSA-9664433 | Leishmania parasite growth and survival | 7.767274e-01 | 0.110 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.767274e-01 | 0.110 |
R-HSA-9694516 | SARS-CoV-2 Infection | 7.831757e-01 | 0.106 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 7.936020e-01 | 0.100 |
R-HSA-3781865 | Diseases of glycosylation | 7.952182e-01 | 0.100 |
R-HSA-983712 | Ion channel transport | 8.031128e-01 | 0.095 |
R-HSA-168898 | Toll-like Receptor Cascades | 8.061855e-01 | 0.094 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 8.107055e-01 | 0.091 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.236475e-01 | 0.084 |
R-HSA-72172 | mRNA Splicing | 8.264021e-01 | 0.083 |
R-HSA-397014 | Muscle contraction | 8.370001e-01 | 0.077 |
R-HSA-418594 | G alpha (i) signalling events | 8.478275e-01 | 0.072 |
R-HSA-9734767 | Developmental Cell Lineages | 8.909914e-01 | 0.050 |
R-HSA-416476 | G alpha (q) signalling events | 8.918493e-01 | 0.050 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.061957e-01 | 0.043 |
R-HSA-168249 | Innate Immune System | 9.071895e-01 | 0.042 |
R-HSA-1483257 | Phospholipid metabolism | 9.153668e-01 | 0.038 |
R-HSA-388396 | GPCR downstream signalling | 9.493374e-01 | 0.023 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.582507e-01 | 0.019 |
R-HSA-9824439 | Bacterial Infection Pathways | 9.605144e-01 | 0.017 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.626564e-01 | 0.017 |
R-HSA-8978868 | Fatty acid metabolism | 9.655178e-01 | 0.015 |
R-HSA-372790 | Signaling by GPCR | 9.692698e-01 | 0.014 |
R-HSA-5668914 | Diseases of metabolism | 9.706042e-01 | 0.013 |
R-HSA-449147 | Signaling by Interleukins | 9.940117e-01 | 0.003 |
R-HSA-382551 | Transport of small molecules | 9.969761e-01 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 9.995592e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.717 | 0.422 | 1 | 0.916 |
JNK2 |
0.710 | 0.490 | 1 | 0.860 |
CDK18 |
0.709 | 0.436 | 1 | 0.866 |
HIPK4 |
0.709 | 0.336 | 1 | 0.789 |
DYRK2 |
0.708 | 0.415 | 1 | 0.899 |
CDK19 |
0.706 | 0.427 | 1 | 0.861 |
CDK3 |
0.706 | 0.386 | 1 | 0.863 |
CDK7 |
0.705 | 0.426 | 1 | 0.861 |
CDK1 |
0.705 | 0.437 | 1 | 0.853 |
JNK3 |
0.704 | 0.479 | 1 | 0.861 |
DYRK4 |
0.704 | 0.409 | 1 | 0.907 |
CDK17 |
0.703 | 0.440 | 1 | 0.857 |
KIS |
0.703 | 0.365 | 1 | 0.861 |
P38B |
0.702 | 0.449 | 1 | 0.877 |
P38D |
0.702 | 0.454 | 1 | 0.895 |
P38G |
0.701 | 0.450 | 1 | 0.863 |
HIPK1 |
0.701 | 0.396 | 1 | 0.878 |
CDK8 |
0.701 | 0.416 | 1 | 0.851 |
CLK3 |
0.700 | 0.285 | 1 | 0.690 |
SRPK1 |
0.700 | 0.230 | -3 | 0.703 |
ERK1 |
0.700 | 0.425 | 1 | 0.881 |
CDK16 |
0.697 | 0.421 | 1 | 0.856 |
CDK10 |
0.697 | 0.403 | 1 | 0.856 |
CDK5 |
0.695 | 0.387 | 1 | 0.854 |
P38A |
0.694 | 0.420 | 1 | 0.861 |
CDK13 |
0.694 | 0.401 | 1 | 0.864 |
JNK1 |
0.694 | 0.432 | 1 | 0.845 |
CDK12 |
0.693 | 0.404 | 1 | 0.867 |
CDK14 |
0.691 | 0.420 | 1 | 0.847 |
ERK5 |
0.691 | 0.278 | 1 | 0.702 |
CDK9 |
0.689 | 0.399 | 1 | 0.862 |
NLK |
0.689 | 0.378 | 1 | 0.721 |
HIPK3 |
0.688 | 0.367 | 1 | 0.849 |
CLK2 |
0.688 | 0.234 | -3 | 0.682 |
DYRK1B |
0.687 | 0.376 | 1 | 0.869 |
MAK |
0.687 | 0.322 | -2 | 0.650 |
DYRK1A |
0.685 | 0.329 | 1 | 0.832 |
ERK2 |
0.681 | 0.396 | 1 | 0.852 |
SRPK2 |
0.680 | 0.162 | -3 | 0.638 |
CDKL5 |
0.679 | 0.140 | -3 | 0.736 |
DYRK3 |
0.678 | 0.287 | 1 | 0.872 |
ICK |
0.676 | 0.230 | -3 | 0.773 |
MTOR |
0.676 | 0.150 | 1 | 0.535 |
PRKD1 |
0.676 | 0.133 | -3 | 0.764 |
CLK1 |
0.676 | 0.217 | -3 | 0.680 |
MOK |
0.676 | 0.293 | 1 | 0.855 |
CDK6 |
0.674 | 0.377 | 1 | 0.856 |
CLK4 |
0.673 | 0.195 | -3 | 0.696 |
CDKL1 |
0.672 | 0.114 | -3 | 0.737 |
COT |
0.672 | 0.040 | 2 | 0.706 |
PIM3 |
0.672 | 0.086 | -3 | 0.754 |
NDR2 |
0.672 | 0.094 | -3 | 0.758 |
SRPK3 |
0.672 | 0.139 | -3 | 0.673 |
CDK4 |
0.671 | 0.381 | 1 | 0.871 |
RSK2 |
0.671 | 0.108 | -3 | 0.714 |
GSK3A |
0.671 | 0.144 | 4 | 0.138 |
CDK2 |
0.670 | 0.286 | 1 | 0.792 |
CDC7 |
0.669 | 0.031 | 1 | 0.401 |
MOS |
0.668 | 0.083 | 1 | 0.470 |
P90RSK |
0.667 | 0.103 | -3 | 0.722 |
ATR |
0.665 | 0.058 | 1 | 0.498 |
PRKD2 |
0.664 | 0.070 | -3 | 0.711 |
PIM1 |
0.664 | 0.079 | -3 | 0.707 |
RSK4 |
0.663 | 0.104 | -3 | 0.703 |
SKMLCK |
0.662 | 0.038 | -2 | 0.717 |
RSK3 |
0.662 | 0.066 | -3 | 0.702 |
ERK7 |
0.661 | 0.182 | 2 | 0.547 |
MAPKAPK2 |
0.660 | 0.072 | -3 | 0.676 |
WNK1 |
0.660 | -0.020 | -2 | 0.749 |
GRK1 |
0.660 | 0.040 | -2 | 0.612 |
PKN3 |
0.659 | 0.032 | -3 | 0.738 |
PRPK |
0.659 | -0.045 | -1 | 0.690 |
CAMK1B |
0.658 | 0.017 | -3 | 0.754 |
IKKB |
0.657 | -0.040 | -2 | 0.605 |
CAMK2A |
0.657 | 0.087 | 2 | 0.677 |
NUAK2 |
0.656 | 0.008 | -3 | 0.753 |
NDR1 |
0.656 | 0.018 | -3 | 0.740 |
LATS2 |
0.656 | 0.048 | -5 | 0.708 |
RIPK3 |
0.655 | -0.066 | 3 | 0.358 |
GSK3B |
0.654 | 0.057 | 4 | 0.141 |
CAMK2D |
0.654 | 0.054 | -3 | 0.743 |
PKN2 |
0.654 | 0.000 | -3 | 0.727 |
NEK6 |
0.654 | -0.020 | -2 | 0.667 |
CAMK2G |
0.654 | -0.024 | 2 | 0.668 |
PDHK4 |
0.653 | -0.071 | 1 | 0.469 |
MAPKAPK3 |
0.653 | 0.031 | -3 | 0.706 |
AURC |
0.653 | 0.034 | -2 | 0.501 |
RAF1 |
0.653 | -0.114 | 1 | 0.408 |
PKCD |
0.653 | 0.027 | 2 | 0.646 |
MST4 |
0.653 | -0.041 | 2 | 0.770 |
CHAK2 |
0.653 | -0.016 | -1 | 0.689 |
CAMLCK |
0.652 | 0.012 | -2 | 0.677 |
DAPK2 |
0.652 | 0.019 | -3 | 0.765 |
DSTYK |
0.652 | -0.064 | 2 | 0.758 |
PKACB |
0.652 | 0.052 | -2 | 0.523 |
DNAPK |
0.650 | 0.025 | 1 | 0.447 |
PRP4 |
0.650 | 0.194 | -3 | 0.619 |
NIK |
0.650 | 0.003 | -3 | 0.751 |
AKT2 |
0.650 | 0.066 | -3 | 0.646 |
PASK |
0.650 | 0.167 | -3 | 0.785 |
PKCA |
0.649 | 0.042 | 2 | 0.615 |
MPSK1 |
0.649 | 0.098 | 1 | 0.518 |
PKCB |
0.649 | 0.018 | 2 | 0.621 |
IKKA |
0.649 | 0.001 | -2 | 0.603 |
SMG1 |
0.649 | 0.021 | 1 | 0.485 |
PKCG |
0.648 | 0.013 | 2 | 0.617 |
PDHK1 |
0.648 | -0.088 | 1 | 0.452 |
IKKE |
0.648 | -0.095 | 1 | 0.335 |
MLK2 |
0.648 | 0.019 | 2 | 0.675 |
P70S6KB |
0.648 | 0.018 | -3 | 0.708 |
PKACG |
0.648 | -0.001 | -2 | 0.574 |
MARK4 |
0.648 | -0.074 | 4 | 0.315 |
CAMK2B |
0.648 | 0.028 | 2 | 0.652 |
MLK3 |
0.648 | 0.015 | 2 | 0.632 |
MSK1 |
0.647 | 0.046 | -3 | 0.685 |
LATS1 |
0.647 | 0.088 | -3 | 0.777 |
PRKD3 |
0.647 | 0.032 | -3 | 0.689 |
TBK1 |
0.647 | -0.116 | 1 | 0.336 |
PRKX |
0.646 | 0.049 | -3 | 0.632 |
BMPR2 |
0.646 | -0.155 | -2 | 0.687 |
AMPKA1 |
0.646 | -0.051 | -3 | 0.748 |
BCKDK |
0.646 | -0.089 | -1 | 0.627 |
ULK2 |
0.646 | -0.118 | 2 | 0.610 |
NEK7 |
0.646 | -0.108 | -3 | 0.776 |
TSSK1 |
0.645 | -0.013 | -3 | 0.764 |
MASTL |
0.645 | -0.029 | -2 | 0.641 |
PIM2 |
0.645 | 0.064 | -3 | 0.682 |
GCN2 |
0.645 | -0.161 | 2 | 0.663 |
GRK5 |
0.645 | -0.045 | -3 | 0.704 |
MLK1 |
0.645 | -0.090 | 2 | 0.688 |
IRE1 |
0.645 | -0.075 | 1 | 0.484 |
AMPKA2 |
0.645 | -0.027 | -3 | 0.727 |
GRK7 |
0.645 | 0.035 | 1 | 0.389 |
RIPK1 |
0.644 | -0.096 | 1 | 0.442 |
GRK6 |
0.644 | -0.040 | 1 | 0.385 |
HUNK |
0.643 | -0.129 | 2 | 0.644 |
MSK2 |
0.643 | 0.007 | -3 | 0.695 |
PKCZ |
0.642 | -0.011 | 2 | 0.648 |
PAK1 |
0.642 | -0.016 | -2 | 0.644 |
PKG2 |
0.642 | 0.016 | -2 | 0.522 |
QSK |
0.641 | -0.041 | 4 | 0.316 |
FAM20C |
0.641 | -0.026 | 2 | 0.505 |
TSSK2 |
0.641 | -0.035 | -5 | 0.780 |
PHKG1 |
0.641 | -0.022 | -3 | 0.726 |
PAK6 |
0.641 | 0.019 | -2 | 0.555 |
SGK3 |
0.641 | 0.024 | -3 | 0.688 |
NUAK1 |
0.641 | -0.021 | -3 | 0.703 |
AKT3 |
0.641 | 0.090 | -3 | 0.610 |
MNK1 |
0.640 | 0.006 | -2 | 0.632 |
TGFBR2 |
0.640 | -0.072 | -2 | 0.573 |
NEK9 |
0.640 | -0.098 | 2 | 0.699 |
ATM |
0.640 | -0.059 | 1 | 0.454 |
PAK3 |
0.640 | -0.031 | -2 | 0.640 |
DLK |
0.640 | -0.068 | 1 | 0.408 |
PKR |
0.639 | -0.041 | 1 | 0.489 |
BMPR1B |
0.639 | -0.016 | 1 | 0.351 |
WNK3 |
0.638 | -0.196 | 1 | 0.432 |
IRE2 |
0.638 | -0.055 | 2 | 0.583 |
TLK2 |
0.638 | -0.002 | 1 | 0.459 |
ANKRD3 |
0.638 | -0.084 | 1 | 0.451 |
VRK2 |
0.638 | 0.026 | 1 | 0.537 |
PKCH |
0.638 | -0.022 | 2 | 0.590 |
MYLK4 |
0.637 | -0.017 | -2 | 0.614 |
MNK2 |
0.635 | -0.043 | -2 | 0.633 |
AURB |
0.635 | -0.013 | -2 | 0.498 |
MELK |
0.635 | -0.037 | -3 | 0.711 |
AKT1 |
0.635 | 0.036 | -3 | 0.657 |
TTBK2 |
0.635 | -0.104 | 2 | 0.562 |
NIM1 |
0.635 | -0.103 | 3 | 0.336 |
NEK2 |
0.634 | -0.067 | 2 | 0.690 |
MARK3 |
0.634 | -0.072 | 4 | 0.268 |
SIK |
0.633 | -0.050 | -3 | 0.677 |
ULK1 |
0.633 | -0.126 | -3 | 0.719 |
MLK4 |
0.633 | -0.044 | 2 | 0.601 |
PINK1 |
0.633 | 0.041 | 1 | 0.635 |
CAMK4 |
0.632 | -0.062 | -3 | 0.712 |
CHK1 |
0.632 | 0.032 | -3 | 0.718 |
ALK4 |
0.632 | -0.040 | -2 | 0.643 |
CK1E |
0.631 | -0.011 | -3 | 0.487 |
YSK4 |
0.631 | -0.045 | 1 | 0.367 |
TGFBR1 |
0.631 | -0.038 | -2 | 0.619 |
SBK |
0.631 | 0.118 | -3 | 0.556 |
MST3 |
0.630 | -0.018 | 2 | 0.744 |
PKACA |
0.630 | 0.022 | -2 | 0.478 |
QIK |
0.630 | -0.120 | -3 | 0.736 |
CAMK1G |
0.630 | -0.027 | -3 | 0.686 |
GRK4 |
0.630 | -0.111 | -2 | 0.633 |
PAK2 |
0.629 | -0.054 | -2 | 0.617 |
PKCE |
0.628 | 0.007 | 2 | 0.613 |
PKCT |
0.628 | -0.029 | 2 | 0.592 |
CHAK1 |
0.628 | -0.129 | 2 | 0.626 |
WNK4 |
0.628 | -0.101 | -2 | 0.745 |
LKB1 |
0.628 | 0.059 | -3 | 0.729 |
IRAK4 |
0.627 | -0.090 | 1 | 0.457 |
DCAMKL1 |
0.627 | -0.008 | -3 | 0.703 |
MAPKAPK5 |
0.627 | -0.039 | -3 | 0.665 |
SSTK |
0.627 | -0.046 | 4 | 0.315 |
BRSK1 |
0.627 | -0.060 | -3 | 0.704 |
MEK1 |
0.627 | -0.106 | 2 | 0.678 |
NEK5 |
0.626 | -0.049 | 1 | 0.453 |
SGK1 |
0.626 | 0.051 | -3 | 0.586 |
PKCI |
0.626 | -0.021 | 2 | 0.634 |
CK1D |
0.626 | 0.009 | -3 | 0.444 |
BUB1 |
0.625 | 0.058 | -5 | 0.703 |
DRAK1 |
0.625 | -0.086 | 1 | 0.320 |
BRSK2 |
0.625 | -0.085 | -3 | 0.711 |
SMMLCK |
0.625 | -0.021 | -3 | 0.727 |
MARK2 |
0.625 | -0.105 | 4 | 0.242 |
P70S6K |
0.624 | 0.010 | -3 | 0.647 |
SNRK |
0.623 | -0.119 | 2 | 0.505 |
CK1A2 |
0.623 | -0.005 | -3 | 0.446 |
PKN1 |
0.623 | 0.009 | -3 | 0.664 |
AURA |
0.623 | -0.033 | -2 | 0.468 |
PAK4 |
0.623 | 0.002 | -2 | 0.489 |
GAK |
0.623 | 0.018 | 1 | 0.465 |
ALK2 |
0.622 | -0.071 | -2 | 0.616 |
PLK1 |
0.622 | -0.120 | -2 | 0.585 |
ACVR2B |
0.622 | -0.069 | -2 | 0.593 |
PLK3 |
0.622 | -0.089 | 2 | 0.608 |
CK2A2 |
0.622 | -0.031 | 1 | 0.289 |
MEKK1 |
0.622 | -0.117 | 1 | 0.423 |
MEK5 |
0.621 | -0.120 | 2 | 0.663 |
CK1G1 |
0.621 | -0.033 | -3 | 0.467 |
GRK2 |
0.621 | -0.066 | -2 | 0.558 |
TLK1 |
0.621 | -0.095 | -2 | 0.644 |
DAPK3 |
0.621 | -0.014 | -3 | 0.715 |
BRAF |
0.620 | -0.061 | -4 | 0.774 |
ACVR2A |
0.620 | -0.079 | -2 | 0.567 |
MARK1 |
0.620 | -0.113 | 4 | 0.283 |
PLK4 |
0.619 | -0.093 | 2 | 0.443 |
PDK1 |
0.619 | -0.009 | 1 | 0.436 |
ZAK |
0.618 | -0.108 | 1 | 0.378 |
DCAMKL2 |
0.618 | -0.029 | -3 | 0.719 |
MRCKB |
0.618 | 0.012 | -3 | 0.657 |
DAPK1 |
0.618 | -0.008 | -3 | 0.705 |
PAK5 |
0.618 | -0.024 | -2 | 0.491 |
MEKK2 |
0.618 | -0.102 | 2 | 0.645 |
PDHK3_TYR |
0.617 | 0.218 | 4 | 0.375 |
NEK11 |
0.617 | -0.079 | 1 | 0.399 |
TAO3 |
0.617 | -0.067 | 1 | 0.416 |
BMPR1A |
0.617 | -0.056 | 1 | 0.326 |
PHKG2 |
0.617 | -0.089 | -3 | 0.688 |
PERK |
0.617 | -0.129 | -2 | 0.614 |
CAMK1D |
0.617 | -0.010 | -3 | 0.629 |
CAMKK2 |
0.616 | -0.003 | -2 | 0.614 |
DMPK1 |
0.616 | 0.047 | -3 | 0.678 |
CK2A1 |
0.616 | -0.035 | 1 | 0.267 |
GCK |
0.616 | -0.014 | 1 | 0.397 |
MAP3K15 |
0.615 | -0.042 | 1 | 0.389 |
CRIK |
0.615 | 0.064 | -3 | 0.671 |
ROCK2 |
0.615 | 0.013 | -3 | 0.702 |
MEKK6 |
0.614 | -0.071 | 1 | 0.431 |
NEK4 |
0.613 | -0.075 | 1 | 0.416 |
YANK3 |
0.613 | 0.004 | 2 | 0.301 |
CHK2 |
0.612 | 0.003 | -3 | 0.598 |
LRRK2 |
0.612 | -0.026 | 2 | 0.707 |
CAMKK1 |
0.612 | -0.078 | -2 | 0.621 |
MEKK3 |
0.612 | -0.166 | 1 | 0.406 |
PDHK4_TYR |
0.612 | 0.136 | 2 | 0.722 |
KHS1 |
0.611 | -0.014 | 1 | 0.405 |
NEK8 |
0.611 | -0.101 | 2 | 0.674 |
HRI |
0.611 | -0.186 | -2 | 0.634 |
TTBK1 |
0.611 | -0.106 | 2 | 0.472 |
GRK3 |
0.611 | -0.065 | -2 | 0.524 |
PBK |
0.611 | 0.011 | 1 | 0.442 |
HPK1 |
0.611 | -0.039 | 1 | 0.388 |
TAK1 |
0.610 | -0.030 | 1 | 0.416 |
LIMK2_TYR |
0.610 | 0.123 | -3 | 0.764 |
MRCKA |
0.610 | -0.000 | -3 | 0.670 |
PLK2 |
0.610 | -0.030 | -3 | 0.635 |
TNIK |
0.609 | -0.050 | 3 | 0.351 |
EEF2K |
0.609 | -0.070 | 3 | 0.373 |
CAMK1A |
0.609 | 0.001 | -3 | 0.609 |
TESK1_TYR |
0.609 | 0.095 | 3 | 0.404 |
HGK |
0.609 | -0.061 | 3 | 0.366 |
KHS2 |
0.608 | -0.022 | 1 | 0.410 |
NEK1 |
0.608 | -0.072 | 1 | 0.423 |
STK33 |
0.608 | -0.061 | 2 | 0.459 |
HASPIN |
0.608 | -0.012 | -1 | 0.569 |
IRAK1 |
0.608 | -0.180 | -1 | 0.582 |
TAO2 |
0.607 | -0.113 | 2 | 0.702 |
PKMYT1_TYR |
0.606 | 0.060 | 3 | 0.401 |
MINK |
0.606 | -0.096 | 1 | 0.393 |
LOK |
0.605 | -0.047 | -2 | 0.577 |
MAP2K4_TYR |
0.605 | 0.100 | -1 | 0.692 |
SLK |
0.605 | -0.037 | -2 | 0.520 |
MAP2K6_TYR |
0.603 | 0.053 | -1 | 0.707 |
VRK1 |
0.602 | -0.147 | 2 | 0.663 |
YSK1 |
0.602 | -0.072 | 2 | 0.697 |
BMPR2_TYR |
0.601 | 0.040 | -1 | 0.719 |
PDHK1_TYR |
0.601 | 0.040 | -1 | 0.712 |
MST2 |
0.601 | -0.108 | 1 | 0.394 |
PKG1 |
0.600 | -0.029 | -2 | 0.461 |
EPHA6 |
0.599 | -0.017 | -1 | 0.696 |
ROCK1 |
0.598 | -0.021 | -3 | 0.663 |
MAP2K7_TYR |
0.598 | -0.068 | 2 | 0.694 |
NEK3 |
0.597 | -0.084 | 1 | 0.419 |
TNK2 |
0.594 | -0.026 | 3 | 0.357 |
MYO3B |
0.594 | -0.051 | 2 | 0.706 |
MST1 |
0.593 | -0.112 | 1 | 0.387 |
PINK1_TYR |
0.593 | -0.146 | 1 | 0.468 |
RIPK2 |
0.592 | -0.188 | 1 | 0.347 |
RET |
0.592 | -0.121 | 1 | 0.444 |
DDR1 |
0.592 | -0.101 | 4 | 0.328 |
MST1R |
0.591 | -0.125 | 3 | 0.353 |
BIKE |
0.590 | -0.027 | 1 | 0.417 |
LIMK1_TYR |
0.590 | -0.088 | 2 | 0.684 |
AAK1 |
0.590 | 0.021 | 1 | 0.392 |
CK1A |
0.590 | -0.032 | -3 | 0.365 |
FGR |
0.589 | -0.035 | 1 | 0.418 |
OSR1 |
0.588 | -0.080 | 2 | 0.661 |
ASK1 |
0.588 | -0.079 | 1 | 0.373 |
JAK2 |
0.588 | -0.122 | 1 | 0.442 |
EPHB4 |
0.588 | -0.089 | -1 | 0.655 |
DDR2 |
0.587 | -0.045 | 3 | 0.373 |
ROS1 |
0.587 | -0.127 | 3 | 0.311 |
MEK2 |
0.587 | -0.178 | 2 | 0.644 |
TTK |
0.587 | -0.112 | -2 | 0.597 |
CSF1R |
0.587 | -0.125 | 3 | 0.336 |
TNK1 |
0.587 | -0.060 | 3 | 0.318 |
FGFR2 |
0.586 | -0.059 | 3 | 0.396 |
TYK2 |
0.586 | -0.201 | 1 | 0.436 |
TNNI3K_TYR |
0.585 | -0.029 | 1 | 0.490 |
KDR |
0.584 | -0.081 | 3 | 0.328 |
LCK |
0.584 | -0.082 | -1 | 0.684 |
YES1 |
0.584 | -0.110 | -1 | 0.681 |
TEK |
0.583 | -0.045 | 3 | 0.322 |
EPHA4 |
0.583 | -0.053 | 2 | 0.625 |
TYRO3 |
0.583 | -0.159 | 3 | 0.328 |
MYO3A |
0.583 | -0.092 | 1 | 0.431 |
JAK3 |
0.583 | -0.124 | 1 | 0.415 |
JAK1 |
0.583 | -0.077 | 1 | 0.388 |
ABL2 |
0.582 | -0.130 | -1 | 0.604 |
YANK2 |
0.582 | -0.016 | 2 | 0.309 |
BLK |
0.581 | -0.089 | -1 | 0.677 |
FER |
0.580 | -0.145 | 1 | 0.421 |
HCK |
0.580 | -0.129 | -1 | 0.670 |
TXK |
0.580 | -0.057 | 1 | 0.360 |
ALPHAK3 |
0.580 | -0.072 | -1 | 0.608 |
ABL1 |
0.579 | -0.130 | -1 | 0.593 |
FGFR1 |
0.579 | -0.081 | 3 | 0.351 |
FYN |
0.578 | -0.056 | -1 | 0.696 |
KIT |
0.578 | -0.133 | 3 | 0.356 |
INSRR |
0.578 | -0.157 | 3 | 0.340 |
MET |
0.578 | -0.108 | 3 | 0.344 |
EPHB1 |
0.577 | -0.124 | 1 | 0.390 |
WEE1_TYR |
0.577 | -0.085 | -1 | 0.592 |
EPHB3 |
0.577 | -0.102 | -1 | 0.643 |
NEK10_TYR |
0.577 | -0.092 | 1 | 0.356 |
TAO1 |
0.576 | -0.139 | 1 | 0.374 |
SRMS |
0.576 | -0.125 | 1 | 0.383 |
EPHA7 |
0.576 | -0.073 | 2 | 0.609 |
FGFR3 |
0.576 | -0.079 | 3 | 0.381 |
ALK |
0.574 | -0.140 | 3 | 0.327 |
ITK |
0.573 | -0.134 | -1 | 0.630 |
LTK |
0.572 | -0.135 | 3 | 0.344 |
AXL |
0.572 | -0.142 | 3 | 0.346 |
PDGFRB |
0.572 | -0.201 | 3 | 0.346 |
FLT1 |
0.572 | -0.082 | -1 | 0.666 |
LYN |
0.572 | -0.107 | 3 | 0.327 |
EPHA3 |
0.572 | -0.097 | 2 | 0.589 |
EPHA1 |
0.571 | -0.132 | 3 | 0.326 |
MERTK |
0.571 | -0.147 | 3 | 0.332 |
BMX |
0.570 | -0.113 | -1 | 0.564 |
EPHB2 |
0.570 | -0.143 | -1 | 0.630 |
FLT3 |
0.570 | -0.217 | 3 | 0.323 |
PDGFRA |
0.570 | -0.176 | 3 | 0.337 |
PTK6 |
0.569 | -0.123 | -1 | 0.561 |
PTK2 |
0.568 | -0.029 | -1 | 0.691 |
TEC |
0.568 | -0.150 | -1 | 0.549 |
ERBB2 |
0.567 | -0.134 | 1 | 0.369 |
FLT4 |
0.566 | -0.140 | 3 | 0.349 |
FRK |
0.566 | -0.145 | -1 | 0.652 |
SRC |
0.566 | -0.098 | -1 | 0.667 |
CK1G3 |
0.566 | -0.043 | -3 | 0.324 |
EPHA8 |
0.566 | -0.085 | -1 | 0.655 |
NTRK3 |
0.564 | -0.098 | -1 | 0.609 |
BTK |
0.564 | -0.214 | -1 | 0.594 |
MATK |
0.563 | -0.105 | -1 | 0.545 |
INSR |
0.563 | -0.176 | 3 | 0.322 |
NTRK1 |
0.563 | -0.184 | -1 | 0.640 |
STLK3 |
0.563 | -0.154 | 1 | 0.357 |
FGFR4 |
0.562 | -0.082 | -1 | 0.583 |
EPHA5 |
0.562 | -0.123 | 2 | 0.595 |
PTK2B |
0.562 | -0.117 | -1 | 0.574 |
ERBB4 |
0.561 | -0.062 | 1 | 0.303 |
CK1G2 |
0.560 | -0.037 | -3 | 0.398 |
EGFR |
0.560 | -0.092 | 1 | 0.303 |
CSK |
0.560 | -0.126 | 2 | 0.611 |
NTRK2 |
0.559 | -0.197 | 3 | 0.334 |
EPHA2 |
0.559 | -0.082 | -1 | 0.619 |
SYK |
0.558 | -0.058 | -1 | 0.661 |
IGF1R |
0.553 | -0.151 | 3 | 0.308 |
ZAP70 |
0.550 | -0.038 | -1 | 0.593 |
MUSK |
0.549 | -0.141 | 1 | 0.310 |
FES |
0.542 | -0.136 | -1 | 0.543 |