Motif 297 (n=117)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0J9YX86 GOLGA8Q S553 ochoa Golgin A8 family member Q None
A0A1B0GVZ6 MBD3L2B S137 ochoa Methyl-CpG-binding domain protein 3-like 2B None
A4D1S0 KLRG2 S212 ochoa Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) None
A6NE82 MBD3L3 S137 ochoa Methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3) None
A6NMD2 GOLGA8J S553 ochoa Golgin subfamily A member 8J None
A6NNZ2 TUBB8B S275 ochoa Tubulin beta 8B Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
A7E2V4 ZSWIM8 S1089 ochoa Zinc finger SWIM domain-containing protein 8 Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}.
H3BSY2 GOLGA8M S553 ochoa Golgin subfamily A member 8M None
H7C1W4 None S55 ochoa Uncharacterized protein None
I6L899 GOLGA8R S552 ochoa Golgin subfamily A member 8R None
K7ELQ4 ATF7-NPFF S171 ochoa ATF7-NPFF readthrough None
O00139 KIF2A S75 ochoa Kinesin-like protein KIF2A (Kinesin-2) (hK2) Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}.
O14654 IRS4 S439 ochoa Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.
O15075 DCLK1 S334 ochoa Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
O15119 TBX3 S432 ochoa T-box transcription factor TBX3 (T-box protein 3) Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}.
O43683 BUB1 S593 ochoa|psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O60239 SH3BP5 S351 ochoa SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}.
O75161 NPHP4 S510 ochoa Nephrocystin-4 (Nephroretinin) Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}.
O75179 ANKRD17 S2042 ochoa|psp Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75376 NCOR1 S1699 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O94967 WDR47 Y294 ochoa WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) None
P04350 TUBB4A S275 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P04920 SLC4A2 S170 ochoa Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}.
P07437 TUBB S275 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0CJ92 GOLGA8H S553 ochoa Golgin subfamily A member 8H None
P0DPH7 TUBA3C Y262 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D Y262 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P16220 CREB1 S257 psp Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1) Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). {ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:14536081}.
P24928 POLR2A S1508 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P27815 PDE4A S125 ochoa 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
P35670 ATP7B S478 psp Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.
P35711 SOX5 S411 ochoa Transcription factor SOX-5 Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}.
P35712 SOX6 S439 ochoa Transcription factor SOX-6 Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}.
P36507 MAP2K2 S23 ochoa Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}.
P36871 PGM1 S134 ochoa Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}.
P49757 NUMB S241 ochoa Protein numb homolog (h-Numb) (Protein S171) Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
P50613 CDK7 S161 ochoa|psp Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}.
P51531 SMARCA2 S172 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P53367 ARFIP1 S76 ochoa Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.
P54646 PRKAA2 S173 ochoa|psp 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
P58012 FOXL2 S323 psp Forkhead box protein L2 Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}.
P68363 TUBA1B Y262 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A Y262 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P68371 TUBB4B S275 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q03111 MLLT1 S152 ochoa Protein ENL (YEATS domain-containing protein 1) Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.
Q03164 KMT2A S2164 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q07864 POLE S1201 ochoa DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}.
Q0JRZ9 FCHO2 S493 ochoa F-BAR domain only protein 2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Q0VDD7 BRME1 S367 ochoa Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}.
Q13131 PRKAA1 S184 ochoa 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
Q13153 PAK1 S220 ochoa Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}.
Q13428 TCOF1 S1111 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13885 TUBB2A S275 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14160 SCRIB S1306 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q15772 SPEG S19 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q18PE1 DOK7 S422 ochoa Protein Dok-7 (Downstream of tyrosine kinase 7) Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}.
Q2TAL5 SMTNL2 S278 ochoa Smoothelin-like protein 2 None
Q3ZCM7 TUBB8 S275 ochoa Tubulin beta-8 chain (Tubulin beta 8 class VIII) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}.
Q4ZG55 GREB1 S317 ochoa Protein GREB1 (Gene regulated in breast cancer 1 protein) May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Q53GS7 GLE1 S96 ochoa mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.
Q5R3F8 ELFN2 S644 ochoa Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62) Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.
Q5T7P8 SYT6 S97 ochoa Synaptotagmin-6 (Synaptotagmin VI) (SytVI) May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.
Q5TGY3 AHDC1 S176 ochoa Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}.
Q5THJ4 VPS13D S2689 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q68CZ2 TNS3 S687 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6DKI7 PVRIG S207 ochoa Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}.
Q6F5E8 CARMIL2 S993 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6JBY9 RCSD1 S105 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6NV74 CRACDL S490 ochoa CRACD-like protein None
Q6P2E9 EDC4 S30 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P3S6 FBXO42 S373 ochoa F-box only protein 42 (Just one F-box and Kelch domain-containing protein) Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.
Q6PEY2 TUBA3E Y262 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6WCQ1 MPRIP S362 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZUM4 ARHGAP27 S84 ochoa Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q6ZW31 SYDE1 S39 ochoa Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.
Q71U36 TUBA1A Y262 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7L2J0 MEPCE S57 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q86VQ1 GLCCI1 S105 ochoa Glucocorticoid-induced transcript 1 protein None
Q86YP4 GATAD2A S337 ochoa Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q86YP4 GATAD2A S340 ochoa Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q8IU81 IRF2BP1 S436 ochoa Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}.
Q8IVF2 AHNAK2 S4894 ochoa Protein AHNAK2 None
Q8IVT2 MISP S281 ochoa Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IX07 ZFPM1 S491 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8N0Y2 ZNF444 S232 ochoa Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.
Q8N3V7 SYNPO S232 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8NCD3 HJURP S182 ochoa Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.
Q8NFH5 NUP35 S22 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NHZ7 MBD3L2 S137 ochoa Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2) May displace the NuRD complex from chromatin. {ECO:0000269|PubMed:15701600}.
Q8TEM1 NUP210 S1860 ochoa Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.
Q8WWI1 LMO7 S988 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q93075 TATDN2 S112 ochoa 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}.
Q96EB6 SIRT1 S47 ochoa|psp NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.
Q96FS4 SIPA1 T64 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q99594 TEAD3 S145 ochoa Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Q99698 LYST S2089 ochoa Lysosomal-trafficking regulator (Beige homolog) Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}.
Q99704 DOK1 S281 ochoa Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Q9BQE3 TUBA1C Y262 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BRK4 LZTS2 S99 ochoa Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BUF5 TUBB6 S275 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BVA1 TUBB2B S275 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9BWE0 REPIN1 S24 ochoa DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}.
Q9HBH9 MKNK2 S437 ochoa|psp MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.
Q9NRR5 UBQLN4 T111 ochoa Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9NY65 TUBA8 Y262 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9NYB9 ABI2 S224 ochoa Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
Q9NZJ0 DTL S441 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9NZJ0 DTL S676 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9P0K8 FOXJ2 S43 ochoa Forkhead box protein J2 (Fork head homologous X) [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}.
Q9P107 GMIP S231 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P1Y5 CAMSAP3 S544 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9ULH1 ASAP1 S782 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9UMN6 KMT2B S1887 ochoa Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q9UNF1 MAGED2 S244 ochoa Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.
Q9Y2H5 PLEKHA6 S276 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y2H5 PLEKHA6 S1021 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y4F5 CEP170B S1545 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Download
reactome_id name p -log10_p
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.110223e-16 15.955
R-HSA-9619483 Activation of AMPK downstream of NMDARs 1.110223e-16 15.955
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.110223e-16 15.955
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.110223e-16 15.955
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.110223e-16 15.955
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1.110223e-16 15.955
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.110223e-16 15.955
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.110223e-16 15.955
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.110223e-16 15.955
R-HSA-190872 Transport of connexons to the plasma membrane 1.110223e-16 15.955
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.110223e-16 15.955
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.110223e-16 15.955
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 1.110223e-16 15.955
R-HSA-438064 Post NMDA receptor activation events 1.110223e-16 15.955
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.110223e-16 15.955
R-HSA-9646399 Aggrephagy 1.110223e-16 15.955
R-HSA-437239 Recycling pathway of L1 1.110223e-16 15.955
R-HSA-983189 Kinesins 1.110223e-16 15.955
R-HSA-190861 Gap junction assembly 1.110223e-16 15.955
R-HSA-190828 Gap junction trafficking 1.110223e-16 15.955
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 1.110223e-16 15.955
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.110223e-16 15.955
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.110223e-16 15.955
R-HSA-157858 Gap junction trafficking and regulation 1.110223e-16 15.955
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 1.110223e-16 15.955
R-HSA-9663891 Selective autophagy 1.110223e-16 15.955
R-HSA-373760 L1CAM interactions 1.110223e-16 15.955
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.110223e-16 15.955
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 4.440892e-16 15.353
R-HSA-9833482 PKR-mediated signaling 5.551115e-16 15.256
R-HSA-68877 Mitotic Prometaphase 6.661338e-15 14.176
R-HSA-2467813 Separation of Sister Chromatids 6.883383e-15 14.162
R-HSA-9609690 HCMV Early Events 8.437695e-15 14.074
R-HSA-6807878 COPI-mediated anterograde transport 9.880985e-15 14.005
R-HSA-1632852 Macroautophagy 1.054712e-14 13.977
R-HSA-2132295 MHC class II antigen presentation 1.953993e-14 13.709
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.241851e-14 13.489
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.107825e-14 13.386
R-HSA-68882 Mitotic Anaphase 4.363176e-14 13.360
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.707346e-14 13.327
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 5.273559e-14 13.278
R-HSA-69275 G2/M Transition 5.062617e-14 13.296
R-HSA-9612973 Autophagy 4.929390e-14 13.307
R-HSA-453274 Mitotic G2-G2/M phases 5.950795e-14 13.225
R-HSA-8856688 Golgi-to-ER retrograde transport 6.272760e-14 13.203
R-HSA-5617833 Cilium Assembly 6.983303e-14 13.156
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 2.761125e-13 12.559
R-HSA-1852241 Organelle biogenesis and maintenance 2.832179e-13 12.548
R-HSA-9609646 HCMV Infection 4.545253e-13 12.342
R-HSA-390466 Chaperonin-mediated protein folding 9.889867e-13 12.005
R-HSA-5620924 Intraflagellar transport 1.159850e-12 11.936
R-HSA-391251 Protein folding 2.092215e-12 11.679
R-HSA-199977 ER to Golgi Anterograde Transport 4.527823e-12 11.344
R-HSA-68886 M Phase 6.776579e-12 11.169
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.103562e-11 10.677
R-HSA-112315 Transmission across Chemical Synapses 2.700284e-11 10.569
R-HSA-69278 Cell Cycle, Mitotic 2.702993e-11 10.568
R-HSA-5610787 Hedgehog 'off' state 9.870260e-11 10.006
R-HSA-948021 Transport to the Golgi and subsequent modification 2.528233e-10 9.597
R-HSA-5358351 Signaling by Hedgehog 3.419981e-10 9.466
R-HSA-1640170 Cell Cycle 3.838225e-10 9.416
R-HSA-422475 Axon guidance 3.039120e-09 8.517
R-HSA-112316 Neuronal System 9.001308e-09 8.046
R-HSA-9675108 Nervous system development 9.090694e-09 8.041
R-HSA-913531 Interferon Signaling 1.874576e-08 7.727
R-HSA-446203 Asparagine N-linked glycosylation 2.039304e-06 5.691
R-HSA-199991 Membrane Trafficking 4.574512e-06 5.340
R-HSA-2262752 Cellular responses to stress 4.958411e-06 5.305
R-HSA-162582 Signal Transduction 5.567452e-06 5.254
R-HSA-1280218 Adaptive Immune System 7.647308e-06 5.116
R-HSA-9824446 Viral Infection Pathways 2.453726e-05 4.610
R-HSA-8953897 Cellular responses to stimuli 3.127728e-05 4.505
R-HSA-109582 Hemostasis 5.311036e-05 4.275
R-HSA-5653656 Vesicle-mediated transport 7.714440e-05 4.113
R-HSA-1266738 Developmental Biology 8.385829e-05 4.076
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.356416e-04 3.868
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 2.519770e-04 3.599
R-HSA-380259 Loss of Nlp from mitotic centrosomes 2.519770e-04 3.599
R-HSA-8854518 AURKA Activation by TPX2 3.042394e-04 3.517
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 4.579313e-04 3.339
R-HSA-380287 Centrosome maturation 5.110126e-04 3.292
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 7.284284e-04 3.138
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 8.090899e-04 3.092
R-HSA-5663205 Infectious disease 1.415850e-03 2.849
R-HSA-1280215 Cytokine Signaling in Immune system 2.050021e-03 2.688
R-HSA-9022707 MECP2 regulates transcription factors 2.840785e-03 2.547
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 5.714852e-03 2.243
R-HSA-112382 Formation of RNA Pol II elongation complex 1.172918e-02 1.931
R-HSA-75955 RNA Polymerase II Transcription Elongation 1.225709e-02 1.912
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 1.392179e-02 1.856
R-HSA-6782135 Dual incision in TC-NER 1.509951e-02 1.821
R-HSA-168325 Viral Messenger RNA Synthesis 1.696873e-02 1.770
R-HSA-9707616 Heme signaling 1.761929e-02 1.754
R-HSA-445144 Signal transduction by L1 1.646237e-02 1.784
R-HSA-212165 Epigenetic regulation of gene expression 1.802113e-02 1.744
R-HSA-597592 Post-translational protein modification 1.929320e-02 1.715
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2.171229e-02 1.663
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 2.171229e-02 1.663
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 2.181258e-02 1.661
R-HSA-5609974 Defective PGM1 causes PGM1-CDG 2.302064e-02 1.638
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 2.311957e-02 1.636
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 2.409605e-02 1.618
R-HSA-5578749 Transcriptional regulation by small RNAs 2.488489e-02 1.604
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.568758e-02 1.590
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.604334e-02 1.584
R-HSA-674695 RNA Polymerase II Pre-transcription Events 2.650408e-02 1.577
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 2.910848e-02 1.536
R-HSA-113418 Formation of the Early Elongation Complex 2.910848e-02 1.536
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 3.231001e-02 1.491
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.396040e-02 1.469
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.396040e-02 1.469
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 2.733440e-02 1.563
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.353185e-02 1.475
R-HSA-72086 mRNA Capping 3.069250e-02 1.513
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.231001e-02 1.491
R-HSA-9909396 Circadian clock 2.881835e-02 1.540
R-HSA-9018519 Estrogen-dependent gene expression 3.197309e-02 1.495
R-HSA-9730414 MITF-M-regulated melanocyte development 3.587246e-02 1.445
R-HSA-9652169 Signaling by MAP2K mutants 4.551548e-02 1.342
R-HSA-1855170 IPs transport between nucleus and cytosol 3.735744e-02 1.428
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.735744e-02 1.428
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.910292e-02 1.408
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.268494e-02 1.370
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.737365e-02 1.427
R-HSA-141424 Amplification of signal from the kinetochores 3.737365e-02 1.427
R-HSA-162599 Late Phase of HIV Life Cycle 3.671833e-02 1.435
R-HSA-8875513 MET interacts with TNS proteins 3.807488e-02 1.419
R-HSA-180910 Vpr-mediated nuclear import of PICs 4.638459e-02 1.334
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 4.268494e-02 1.370
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 3.735744e-02 1.428
R-HSA-162587 HIV Life Cycle 4.818605e-02 1.317
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.910292e-02 1.408
R-HSA-9022692 Regulation of MECP2 expression and activity 3.735744e-02 1.428
R-HSA-180746 Nuclear import of Rev protein 4.087894e-02 1.389
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.575063e-02 1.340
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4.827715e-02 1.316
R-HSA-8878171 Transcriptional regulation by RUNX1 4.354448e-02 1.361
R-HSA-8986944 Transcriptional Regulation by MECP2 4.353998e-02 1.361
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.735744e-02 1.428
R-HSA-9856651 MITF-M-dependent gene expression 4.261369e-02 1.370
R-HSA-168256 Immune System 3.630309e-02 1.440
R-HSA-3247509 Chromatin modifying enzymes 4.872119e-02 1.312
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 5.019747e-02 1.299
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 5.019747e-02 1.299
R-HSA-168276 NS1 Mediated Effects on Host Pathways 5.019747e-02 1.299
R-HSA-8939211 ESR-mediated signaling 5.075261e-02 1.295
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 5.214502e-02 1.283
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 5.214502e-02 1.283
R-HSA-167169 HIV Transcription Elongation 5.214502e-02 1.283
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 5.214502e-02 1.283
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 5.214502e-02 1.283
R-HSA-177243 Interactions of Rev with host cellular proteins 5.214502e-02 1.283
R-HSA-176033 Interactions of Vpr with host cellular proteins 5.214502e-02 1.283
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 5.411928e-02 1.267
R-HSA-3214841 PKMTs methylate histone lysines 5.411928e-02 1.267
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 6.022581e-02 1.220
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 6.749642e-02 1.171
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 5.611971e-02 1.251
R-HSA-167161 HIV Transcription Initiation 5.611971e-02 1.251
R-HSA-75953 RNA Polymerase II Transcription Initiation 5.611971e-02 1.251
R-HSA-73776 RNA Polymerase II Promoter Escape 6.019706e-02 1.220
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 6.437302e-02 1.191
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 6.649674e-02 1.177
R-HSA-69618 Mitotic Spindle Checkpoint 5.607141e-02 1.251
R-HSA-199920 CREB phosphorylation 6.749642e-02 1.171
R-HSA-5696398 Nucleotide Excision Repair 6.355278e-02 1.197
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 6.437302e-02 1.191
R-HSA-5674499 Negative feedback regulation of MAPK pathway 6.022581e-02 1.220
R-HSA-73762 RNA Polymerase I Transcription Initiation 5.814581e-02 1.235
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5.851566e-02 1.233
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 6.437302e-02 1.191
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 8.187065e-02 1.087
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6.649674e-02 1.177
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 7.970929e-02 1.098
R-HSA-165159 MTOR signalling 5.814581e-02 1.235
R-HSA-73893 DNA Damage Bypass 7.300508e-02 1.137
R-HSA-4839726 Chromatin organization 5.937141e-02 1.226
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 8.187065e-02 1.087
R-HSA-211000 Gene Silencing by RNA 6.614451e-02 1.180
R-HSA-9006931 Signaling by Nuclear Receptors 7.880430e-02 1.103
R-HSA-9909648 Regulation of PD-L1(CD274) expression 6.236426e-02 1.205
R-HSA-388841 Regulation of T cell activation by CD28 family 6.476326e-02 1.189
R-HSA-1592230 Mitochondrial biogenesis 8.268092e-02 1.083
R-HSA-3214815 HDACs deacetylate histones 8.659707e-02 1.062
R-HSA-3371556 Cellular response to heat stress 8.855316e-02 1.053
R-HSA-112411 MAPK1 (ERK2) activation 8.897512e-02 1.051
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 8.897512e-02 1.051
R-HSA-9613354 Lipophagy 8.897512e-02 1.051
R-HSA-198693 AKT phosphorylates targets in the nucleus 8.897512e-02 1.051
R-HSA-2980766 Nuclear Envelope Breakdown 9.128505e-02 1.040
R-HSA-389948 Co-inhibition by PD-1 9.185179e-02 1.037
R-HSA-68952 DNA replication initiation 9.602505e-02 1.018
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 9.602505e-02 1.018
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 9.602505e-02 1.018
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 9.602505e-02 1.018
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 9.602505e-02 1.018
R-HSA-191859 snRNP Assembly 9.604595e-02 1.018
R-HSA-194441 Metabolism of non-coding RNA 9.604595e-02 1.018
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 9.845270e-02 1.007
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.099630e-01 0.959
R-HSA-8964616 G beta:gamma signalling through CDC42 1.505103e-01 0.822
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.505103e-01 0.822
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.636146e-01 0.786
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.700914e-01 0.769
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.765184e-01 0.753
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.828960e-01 0.738
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.892246e-01 0.723
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.892246e-01 0.723
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.892246e-01 0.723
R-HSA-6803529 FGFR2 alternative splicing 1.955046e-01 0.709
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.107334e-01 0.956
R-HSA-167172 Transcription of the HIV genome 1.182854e-01 0.927
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 1.686426e-01 0.773
R-HSA-5620916 VxPx cargo-targeting to cilium 1.765184e-01 0.753
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 1.505103e-01 0.822
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.505103e-01 0.822
R-HSA-6802957 Oncogenic MAPK signaling 1.631733e-01 0.787
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.236877e-01 0.908
R-HSA-399954 Sema3A PAK dependent Axon repulsion 1.372024e-01 0.863
R-HSA-8851708 Signaling by FGFR2 IIIa TM 1.700914e-01 0.769
R-HSA-350054 Notch-HLH transcription pathway 1.955046e-01 0.709
R-HSA-73864 RNA Polymerase I Transcription 1.443102e-01 0.841
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2.017363e-01 0.695
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.496518e-01 0.825
R-HSA-73854 RNA Polymerase I Promoter Clearance 1.390106e-01 0.857
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 1.099630e-01 0.959
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.304711e-01 0.884
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 1.505103e-01 0.822
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1.604511e-01 0.795
R-HSA-162906 HIV Infection 1.268246e-01 0.897
R-HSA-170968 Frs2-mediated activation 1.236877e-01 0.908
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 1.604511e-01 0.795
R-HSA-111931 PKA-mediated phosphorylation of CREB 1.828960e-01 0.738
R-HSA-3928664 Ephrin signaling 1.636146e-01 0.786
R-HSA-425381 Bicarbonate transporters 1.030209e-01 0.987
R-HSA-428540 Activation of RAC1 1.099630e-01 0.959
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.892246e-01 0.723
R-HSA-112409 RAF-independent MAPK1/3 activation 1.955046e-01 0.709
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.168518e-01 0.932
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.168518e-01 0.932
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 1.132362e-01 0.946
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.520417e-01 0.818
R-HSA-169893 Prolonged ERK activation events 1.438820e-01 0.842
R-HSA-9005895 Pervasive developmental disorders 1.168518e-01 0.932
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 1.168518e-01 0.932
R-HSA-9697154 Disorders of Nervous System Development 1.168518e-01 0.932
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.304711e-01 0.884
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.443102e-01 0.841
R-HSA-389359 CD28 dependent Vav1 pathway 1.236877e-01 0.908
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 1.236877e-01 0.908
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.304711e-01 0.884
R-HSA-9675151 Disorders of Developmental Biology 1.505103e-01 0.822
R-HSA-70370 Galactose catabolism 1.505103e-01 0.822
R-HSA-392517 Rap1 signalling 1.700914e-01 0.769
R-HSA-6784531 tRNA processing in the nucleus 1.033168e-01 0.986
R-HSA-5632684 Hedgehog 'on' state 1.259627e-01 0.900
R-HSA-5635838 Activation of SMO 1.438820e-01 0.842
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.700914e-01 0.769
R-HSA-9616222 Transcriptional regulation of granulopoiesis 1.033168e-01 0.986
R-HSA-168255 Influenza Infection 1.997578e-01 0.699
R-HSA-200425 Carnitine shuttle 2.017363e-01 0.695
R-HSA-1980143 Signaling by NOTCH1 1.390106e-01 0.857
R-HSA-9764560 Regulation of CDH1 Gene Transcription 1.233903e-01 0.909
R-HSA-1169408 ISG15 antiviral mechanism 1.363774e-01 0.865
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 1.523376e-01 0.817
R-HSA-1643685 Disease 1.074258e-01 0.969
R-HSA-9690406 Transcriptional regulation of testis differentiation 1.505103e-01 0.822
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 2.017363e-01 0.695
R-HSA-5210891 Uptake and function of anthrax toxins 1.570877e-01 0.804
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.210453e-01 0.917
R-HSA-3322077 Glycogen synthesis 1.765184e-01 0.753
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 1.659039e-01 0.780
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.686426e-01 0.773
R-HSA-2028269 Signaling by Hippo 1.570877e-01 0.804
R-HSA-381038 XBP1(S) activates chaperone genes 1.686426e-01 0.773
R-HSA-5633007 Regulation of TP53 Activity 1.612752e-01 0.792
R-HSA-381070 IRE1alpha activates chaperones 1.852287e-01 0.732
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.036201e-01 0.691
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.079201e-01 0.682
R-HSA-70171 Glycolysis 2.133395e-01 0.671
R-HSA-9620244 Long-term potentiation 2.140565e-01 0.669
R-HSA-9932444 ATP-dependent chromatin remodelers 2.140565e-01 0.669
R-HSA-9932451 SWI/SNF chromatin remodelers 2.140565e-01 0.669
R-HSA-203927 MicroRNA (miRNA) biogenesis 2.140565e-01 0.669
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 2.140565e-01 0.669
R-HSA-70221 Glycogen breakdown (glycogenolysis) 2.140565e-01 0.669
R-HSA-9842860 Regulation of endogenous retroelements 2.190140e-01 0.660
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.201456e-01 0.657
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.201456e-01 0.657
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 2.201456e-01 0.657
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 2.201456e-01 0.657
R-HSA-111885 Opioid Signalling 2.247016e-01 0.648
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 2.261880e-01 0.646
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 2.261880e-01 0.646
R-HSA-73863 RNA Polymerase I Transcription Termination 2.261880e-01 0.646
R-HSA-5619507 Activation of HOX genes during differentiation 2.275498e-01 0.643
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 2.275498e-01 0.643
R-HSA-167287 HIV elongation arrest and recovery 2.321839e-01 0.634
R-HSA-167290 Pausing and recovery of HIV elongation 2.321839e-01 0.634
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 2.381273e-01 0.623
R-HSA-5656169 Termination of translesion DNA synthesis 2.381337e-01 0.623
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.381337e-01 0.623
R-HSA-180024 DARPP-32 events 2.381337e-01 0.623
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 2.440378e-01 0.613
R-HSA-68962 Activation of the pre-replicative complex 2.440378e-01 0.613
R-HSA-1483249 Inositol phosphate metabolism 2.504134e-01 0.601
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 2.557101e-01 0.592
R-HSA-397795 G-protein beta:gamma signalling 2.614791e-01 0.583
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 2.614791e-01 0.583
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.614791e-01 0.583
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 2.614791e-01 0.583
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.618767e-01 0.582
R-HSA-4420097 VEGFA-VEGFR2 Pathway 2.647438e-01 0.577
R-HSA-70326 Glucose metabolism 2.704782e-01 0.568
R-HSA-5696400 Dual Incision in GG-NER 2.728842e-01 0.564
R-HSA-1980145 Signaling by NOTCH2 2.728842e-01 0.564
R-HSA-5673000 RAF activation 2.728842e-01 0.564
R-HSA-187687 Signalling to ERKs 2.785211e-01 0.555
R-HSA-68875 Mitotic Prophase 2.790780e-01 0.554
R-HSA-73886 Chromosome Maintenance 2.819434e-01 0.550
R-HSA-111933 Calmodulin induced events 2.841146e-01 0.547
R-HSA-111997 CaM pathway 2.841146e-01 0.547
R-HSA-1839126 FGFR2 mutant receptor activation 2.841146e-01 0.547
R-HSA-8853659 RET signaling 2.841146e-01 0.547
R-HSA-427359 SIRT1 negatively regulates rRNA expression 2.896651e-01 0.538
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 2.896651e-01 0.538
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.896651e-01 0.538
R-HSA-162909 Host Interactions of HIV factors 2.905340e-01 0.537
R-HSA-8875878 MET promotes cell motility 2.951729e-01 0.530
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.951729e-01 0.530
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 2.962548e-01 0.528
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 2.962548e-01 0.528
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 2.962548e-01 0.528
R-HSA-194138 Signaling by VEGF 2.962548e-01 0.528
R-HSA-69206 G1/S Transition 2.962548e-01 0.528
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 3.006384e-01 0.522
R-HSA-114608 Platelet degranulation 3.019691e-01 0.520
R-HSA-187037 Signaling by NTRK1 (TRKA) 3.048235e-01 0.516
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 3.060618e-01 0.514
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 3.060618e-01 0.514
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 3.060618e-01 0.514
R-HSA-9670095 Inhibition of DNA recombination at telomere 3.060618e-01 0.514
R-HSA-5696395 Formation of Incision Complex in GG-NER 3.060618e-01 0.514
R-HSA-1251985 Nuclear signaling by ERBB4 3.060618e-01 0.514
R-HSA-202433 Generation of second messenger molecules 3.060618e-01 0.514
R-HSA-8982491 Glycogen metabolism 3.060618e-01 0.514
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 3.114434e-01 0.507
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.114434e-01 0.507
R-HSA-5218920 VEGFR2 mediated vascular permeability 3.114434e-01 0.507
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.114434e-01 0.507
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 3.114434e-01 0.507
R-HSA-9843745 Adipogenesis 3.162194e-01 0.500
R-HSA-5674135 MAP2K and MAPK activation 3.167837e-01 0.499
R-HSA-9656223 Signaling by RAF1 mutants 3.167837e-01 0.499
R-HSA-5610780 Degradation of GLI1 by the proteasome 3.167837e-01 0.499
R-HSA-5675221 Negative regulation of MAPK pathway 3.167837e-01 0.499
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 3.219024e-01 0.492
R-HSA-111996 Ca-dependent events 3.220829e-01 0.492
R-HSA-3700989 Transcriptional Regulation by TP53 3.261353e-01 0.487
R-HSA-157118 Signaling by NOTCH 3.282997e-01 0.484
R-HSA-392499 Metabolism of proteins 3.324956e-01 0.478
R-HSA-3214858 RMTs methylate histone arginines 3.325592e-01 0.478
R-HSA-3928662 EPHB-mediated forward signaling 3.325592e-01 0.478
R-HSA-69231 Cyclin D associated events in G1 3.325592e-01 0.478
R-HSA-69236 G1 Phase 3.325592e-01 0.478
R-HSA-212436 Generic Transcription Pathway 3.363016e-01 0.473
R-HSA-774815 Nucleosome assembly 3.377370e-01 0.471
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 3.377370e-01 0.471
R-HSA-4608870 Asymmetric localization of PCP proteins 3.377370e-01 0.471
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 3.377370e-01 0.471
R-HSA-1489509 DAG and IP3 signaling 3.377370e-01 0.471
R-HSA-73894 DNA Repair 3.413681e-01 0.467
R-HSA-381119 Unfolded Protein Response (UPR) 3.416973e-01 0.466
R-HSA-72165 mRNA Splicing - Minor Pathway 3.428750e-01 0.465
R-HSA-9649948 Signaling downstream of RAS mutants 3.428750e-01 0.465
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.428750e-01 0.465
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.428750e-01 0.465
R-HSA-6802949 Signaling by RAS mutants 3.428750e-01 0.465
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.473217e-01 0.459
R-HSA-73857 RNA Polymerase II Transcription 3.528787e-01 0.452
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.529305e-01 0.452
R-HSA-9031628 NGF-stimulated transcription 3.530325e-01 0.452
R-HSA-389356 Co-stimulation by CD28 3.530325e-01 0.452
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.580527e-01 0.446
R-HSA-5655253 Signaling by FGFR2 in disease 3.630343e-01 0.440
R-HSA-453279 Mitotic G1 phase and G1/S transition 3.640981e-01 0.439
R-HSA-69620 Cell Cycle Checkpoints 3.663649e-01 0.436
R-HSA-166520 Signaling by NTRKs 3.696553e-01 0.432
R-HSA-69242 S Phase 3.696553e-01 0.432
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.728826e-01 0.428
R-HSA-73772 RNA Polymerase I Promoter Escape 3.728826e-01 0.428
R-HSA-5339562 Uptake and actions of bacterial toxins 3.728826e-01 0.428
R-HSA-9679191 Potential therapeutics for SARS 3.751937e-01 0.426
R-HSA-74160 Gene expression (Transcription) 3.755417e-01 0.425
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.777500e-01 0.423
R-HSA-445355 Smooth Muscle Contraction 3.777500e-01 0.423
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 3.873727e-01 0.412
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.921285e-01 0.407
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 3.921285e-01 0.407
R-HSA-9610379 HCMV Late Events 3.944196e-01 0.404
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 4.015305e-01 0.396
R-HSA-429914 Deadenylation-dependent mRNA decay 4.061773e-01 0.391
R-HSA-8943724 Regulation of PTEN gene transcription 4.107882e-01 0.386
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.107882e-01 0.386
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 4.107882e-01 0.386
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 4.107882e-01 0.386
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 4.107882e-01 0.386
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 4.107882e-01 0.386
R-HSA-2644603 Signaling by NOTCH1 in Cancer 4.107882e-01 0.386
R-HSA-2428928 IRS-related events triggered by IGF1R 4.153637e-01 0.382
R-HSA-450294 MAP kinase activation 4.153637e-01 0.382
R-HSA-112043 PLC beta mediated events 4.153637e-01 0.382
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 4.199039e-01 0.377
R-HSA-375165 NCAM signaling for neurite out-growth 4.199039e-01 0.377
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.199039e-01 0.377
R-HSA-5619102 SLC transporter disorders 4.214137e-01 0.375
R-HSA-373755 Semaphorin interactions 4.244091e-01 0.372
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.244091e-01 0.372
R-HSA-8848021 Signaling by PTK6 4.244091e-01 0.372
R-HSA-2428924 IGF1R signaling cascade 4.288796e-01 0.368
R-HSA-936837 Ion transport by P-type ATPases 4.288796e-01 0.368
R-HSA-72306 tRNA processing 4.320417e-01 0.364
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.333157e-01 0.363
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.399453e-01 0.357
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.399453e-01 0.357
R-HSA-112040 G-protein mediated events 4.420856e-01 0.354
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.420856e-01 0.354
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 4.425666e-01 0.354
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 4.549885e-01 0.342
R-HSA-448424 Interleukin-17 signaling 4.549885e-01 0.342
R-HSA-69202 Cyclin E associated events during G1/S transition 4.549885e-01 0.342
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.592234e-01 0.338
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.592234e-01 0.338
R-HSA-453276 Regulation of mitotic cell cycle 4.592234e-01 0.338
R-HSA-427413 NoRC negatively regulates rRNA expression 4.592234e-01 0.338
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.634256e-01 0.334
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 4.634256e-01 0.334
R-HSA-1236394 Signaling by ERBB4 4.717331e-01 0.326
R-HSA-1226099 Signaling by FGFR in disease 4.717331e-01 0.326
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 4.839556e-01 0.315
R-HSA-383280 Nuclear Receptor transcription pathway 4.879671e-01 0.312
R-HSA-4086400 PCP/CE pathway 4.879671e-01 0.312
R-HSA-5654738 Signaling by FGFR2 4.958976e-01 0.305
R-HSA-6806834 Signaling by MET 4.958976e-01 0.305
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 4.984622e-01 0.302
R-HSA-9707564 Cytoprotection by HMOX1 5.075654e-01 0.295
R-HSA-6798695 Neutrophil degranulation 5.102644e-01 0.292
R-HSA-5687128 MAPK6/MAPK4 signaling 5.151947e-01 0.288
R-HSA-376176 Signaling by ROBO receptors 5.154943e-01 0.288
R-HSA-73884 Base Excision Repair 5.373861e-01 0.270
R-HSA-5683057 MAPK family signaling cascades 5.444092e-01 0.264
R-HSA-2682334 EPH-Ephrin signaling 5.481008e-01 0.261
R-HSA-418990 Adherens junctions interactions 5.529789e-01 0.257
R-HSA-8951664 Neddylation 5.597785e-01 0.252
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 5.654144e-01 0.248
R-HSA-8878159 Transcriptional regulation by RUNX3 5.687973e-01 0.245
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.687973e-01 0.245
R-HSA-157579 Telomere Maintenance 5.687973e-01 0.245
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.721541e-01 0.242
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.721541e-01 0.242
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.721541e-01 0.242
R-HSA-190236 Signaling by FGFR 5.721541e-01 0.242
R-HSA-9705683 SARS-CoV-2-host interactions 5.753595e-01 0.240
R-HSA-9614085 FOXO-mediated transcription 5.754850e-01 0.240
R-HSA-9009391 Extra-nuclear estrogen signaling 5.820698e-01 0.235
R-HSA-1483255 PI Metabolism 5.853240e-01 0.233
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 5.917574e-01 0.228
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 5.949368e-01 0.226
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 5.980917e-01 0.223
R-HSA-69239 Synthesis of DNA 6.043285e-01 0.219
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 6.043285e-01 0.219
R-HSA-9700206 Signaling by ALK in cancer 6.043285e-01 0.219
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 6.074108e-01 0.217
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.074108e-01 0.217
R-HSA-69002 DNA Replication Pre-Initiation 6.104693e-01 0.214
R-HSA-975155 MyD88 dependent cascade initiated on endosome 6.104693e-01 0.214
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 6.135042e-01 0.212
R-HSA-166166 MyD88-independent TLR4 cascade 6.135042e-01 0.212
R-HSA-202403 TCR signaling 6.135042e-01 0.212
R-HSA-5619115 Disorders of transmembrane transporters 6.156258e-01 0.211
R-HSA-2871796 FCERI mediated MAPK activation 6.195037e-01 0.208
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 6.224687e-01 0.206
R-HSA-421270 Cell-cell junction organization 6.237251e-01 0.205
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 6.254108e-01 0.204
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.312269e-01 0.200
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.425917e-01 0.192
R-HSA-5693538 Homology Directed Repair 6.425917e-01 0.192
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.453782e-01 0.190
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.453782e-01 0.190
R-HSA-9759194 Nuclear events mediated by NFE2L2 6.508867e-01 0.186
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.536090e-01 0.185
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.536090e-01 0.185
R-HSA-9816359 Maternal to zygotic transition (MZT) 6.563103e-01 0.183
R-HSA-9711123 Cellular response to chemical stress 6.566898e-01 0.183
R-HSA-9679506 SARS-CoV Infections 6.573927e-01 0.182
R-HSA-8953854 Metabolism of RNA 6.579673e-01 0.182
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 6.669080e-01 0.176
R-HSA-76002 Platelet activation, signaling and aggregation 6.677664e-01 0.175
R-HSA-446728 Cell junction organization 6.749911e-01 0.171
R-HSA-9658195 Leishmania infection 6.803264e-01 0.167
R-HSA-9824443 Parasitic Infection Pathways 6.803264e-01 0.167
R-HSA-5673001 RAF/MAP kinase cascade 6.942081e-01 0.159
R-HSA-163685 Integration of energy metabolism 6.967947e-01 0.157
R-HSA-3858494 Beta-catenin independent WNT signaling 6.967947e-01 0.157
R-HSA-6807070 PTEN Regulation 7.038408e-01 0.153
R-HSA-1257604 PIP3 activates AKT signaling 7.042932e-01 0.152
R-HSA-5684996 MAPK1/MAPK3 signaling 7.059471e-01 0.151
R-HSA-9664407 Parasite infection 7.061533e-01 0.151
R-HSA-9664422 FCGR3A-mediated phagocytosis 7.061533e-01 0.151
R-HSA-9664417 Leishmania phagocytosis 7.061533e-01 0.151
R-HSA-195721 Signaling by WNT 7.092322e-01 0.149
R-HSA-8856828 Clathrin-mediated endocytosis 7.152252e-01 0.146
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 7.180222e-01 0.144
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 7.261754e-01 0.139
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.325439e-01 0.135
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.346339e-01 0.134
R-HSA-69306 DNA Replication 7.367077e-01 0.133
R-HSA-5693532 DNA Double-Strand Break Repair 7.367077e-01 0.133
R-HSA-1500931 Cell-Cell communication 7.374481e-01 0.132
R-HSA-1989781 PPARA activates gene expression 7.408072e-01 0.130
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7.448434e-01 0.128
R-HSA-9006936 Signaling by TGFB family members 7.507811e-01 0.124
R-HSA-418555 G alpha (s) signalling events 7.731918e-01 0.112
R-HSA-5621481 C-type lectin receptors (CLRs) 7.731918e-01 0.112
R-HSA-9006925 Intracellular signaling by second messengers 7.740959e-01 0.111
R-HSA-9664433 Leishmania parasite growth and survival 7.767274e-01 0.110
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.767274e-01 0.110
R-HSA-9694516 SARS-CoV-2 Infection 7.831757e-01 0.106
R-HSA-201681 TCF dependent signaling in response to WNT 7.936020e-01 0.100
R-HSA-3781865 Diseases of glycosylation 7.952182e-01 0.100
R-HSA-983712 Ion channel transport 8.031128e-01 0.095
R-HSA-168898 Toll-like Receptor Cascades 8.061855e-01 0.094
R-HSA-72163 mRNA Splicing - Major Pathway 8.107055e-01 0.091
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8.236475e-01 0.084
R-HSA-72172 mRNA Splicing 8.264021e-01 0.083
R-HSA-397014 Muscle contraction 8.370001e-01 0.077
R-HSA-418594 G alpha (i) signalling events 8.478275e-01 0.072
R-HSA-9734767 Developmental Cell Lineages 8.909914e-01 0.050
R-HSA-416476 G alpha (q) signalling events 8.918493e-01 0.050
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.061957e-01 0.043
R-HSA-168249 Innate Immune System 9.071895e-01 0.042
R-HSA-1483257 Phospholipid metabolism 9.153668e-01 0.038
R-HSA-388396 GPCR downstream signalling 9.493374e-01 0.023
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.582507e-01 0.019
R-HSA-9824439 Bacterial Infection Pathways 9.605144e-01 0.017
R-HSA-425407 SLC-mediated transmembrane transport 9.626564e-01 0.017
R-HSA-8978868 Fatty acid metabolism 9.655178e-01 0.015
R-HSA-372790 Signaling by GPCR 9.692698e-01 0.014
R-HSA-5668914 Diseases of metabolism 9.706042e-01 0.013
R-HSA-449147 Signaling by Interleukins 9.940117e-01 0.003
R-HSA-382551 Transport of small molecules 9.969761e-01 0.001
R-HSA-556833 Metabolism of lipids 9.995592e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.717 0.422 1 0.916
JNK2JNK2 0.710 0.490 1 0.860
CDK18CDK18 0.709 0.436 1 0.866
HIPK4HIPK4 0.709 0.336 1 0.789
DYRK2DYRK2 0.708 0.415 1 0.899
CDK19CDK19 0.706 0.427 1 0.861
CDK3CDK3 0.706 0.386 1 0.863
CDK7CDK7 0.705 0.426 1 0.861
CDK1CDK1 0.705 0.437 1 0.853
JNK3JNK3 0.704 0.479 1 0.861
DYRK4DYRK4 0.704 0.409 1 0.907
CDK17CDK17 0.703 0.440 1 0.857
KISKIS 0.703 0.365 1 0.861
P38BP38B 0.702 0.449 1 0.877
P38DP38D 0.702 0.454 1 0.895
P38GP38G 0.701 0.450 1 0.863
HIPK1HIPK1 0.701 0.396 1 0.878
CDK8CDK8 0.701 0.416 1 0.851
CLK3CLK3 0.700 0.285 1 0.690
SRPK1SRPK1 0.700 0.230 -3 0.703
ERK1ERK1 0.700 0.425 1 0.881
CDK16CDK16 0.697 0.421 1 0.856
CDK10CDK10 0.697 0.403 1 0.856
CDK5CDK5 0.695 0.387 1 0.854
P38AP38A 0.694 0.420 1 0.861
CDK13CDK13 0.694 0.401 1 0.864
JNK1JNK1 0.694 0.432 1 0.845
CDK12CDK12 0.693 0.404 1 0.867
CDK14CDK14 0.691 0.420 1 0.847
ERK5ERK5 0.691 0.278 1 0.702
CDK9CDK9 0.689 0.399 1 0.862
NLKNLK 0.689 0.378 1 0.721
HIPK3HIPK3 0.688 0.367 1 0.849
CLK2CLK2 0.688 0.234 -3 0.682
DYRK1BDYRK1B 0.687 0.376 1 0.869
MAKMAK 0.687 0.322 -2 0.650
DYRK1ADYRK1A 0.685 0.329 1 0.832
ERK2ERK2 0.681 0.396 1 0.852
SRPK2SRPK2 0.680 0.162 -3 0.638
CDKL5CDKL5 0.679 0.140 -3 0.736
DYRK3DYRK3 0.678 0.287 1 0.872
ICKICK 0.676 0.230 -3 0.773
MTORMTOR 0.676 0.150 1 0.535
PRKD1PRKD1 0.676 0.133 -3 0.764
CLK1CLK1 0.676 0.217 -3 0.680
MOKMOK 0.676 0.293 1 0.855
CDK6CDK6 0.674 0.377 1 0.856
CLK4CLK4 0.673 0.195 -3 0.696
CDKL1CDKL1 0.672 0.114 -3 0.737
COTCOT 0.672 0.040 2 0.706
PIM3PIM3 0.672 0.086 -3 0.754
NDR2NDR2 0.672 0.094 -3 0.758
SRPK3SRPK3 0.672 0.139 -3 0.673
CDK4CDK4 0.671 0.381 1 0.871
RSK2RSK2 0.671 0.108 -3 0.714
GSK3AGSK3A 0.671 0.144 4 0.138
CDK2CDK2 0.670 0.286 1 0.792
CDC7CDC7 0.669 0.031 1 0.401
MOSMOS 0.668 0.083 1 0.470
P90RSKP90RSK 0.667 0.103 -3 0.722
ATRATR 0.665 0.058 1 0.498
PRKD2PRKD2 0.664 0.070 -3 0.711
PIM1PIM1 0.664 0.079 -3 0.707
RSK4RSK4 0.663 0.104 -3 0.703
SKMLCKSKMLCK 0.662 0.038 -2 0.717
RSK3RSK3 0.662 0.066 -3 0.702
ERK7ERK7 0.661 0.182 2 0.547
MAPKAPK2MAPKAPK2 0.660 0.072 -3 0.676
WNK1WNK1 0.660 -0.020 -2 0.749
GRK1GRK1 0.660 0.040 -2 0.612
PKN3PKN3 0.659 0.032 -3 0.738
PRPKPRPK 0.659 -0.045 -1 0.690
CAMK1BCAMK1B 0.658 0.017 -3 0.754
IKKBIKKB 0.657 -0.040 -2 0.605
CAMK2ACAMK2A 0.657 0.087 2 0.677
NUAK2NUAK2 0.656 0.008 -3 0.753
NDR1NDR1 0.656 0.018 -3 0.740
LATS2LATS2 0.656 0.048 -5 0.708
RIPK3RIPK3 0.655 -0.066 3 0.358
GSK3BGSK3B 0.654 0.057 4 0.141
CAMK2DCAMK2D 0.654 0.054 -3 0.743
PKN2PKN2 0.654 0.000 -3 0.727
NEK6NEK6 0.654 -0.020 -2 0.667
CAMK2GCAMK2G 0.654 -0.024 2 0.668
PDHK4PDHK4 0.653 -0.071 1 0.469
MAPKAPK3MAPKAPK3 0.653 0.031 -3 0.706
AURCAURC 0.653 0.034 -2 0.501
RAF1RAF1 0.653 -0.114 1 0.408
PKCDPKCD 0.653 0.027 2 0.646
MST4MST4 0.653 -0.041 2 0.770
CHAK2CHAK2 0.653 -0.016 -1 0.689
CAMLCKCAMLCK 0.652 0.012 -2 0.677
DAPK2DAPK2 0.652 0.019 -3 0.765
DSTYKDSTYK 0.652 -0.064 2 0.758
PKACBPKACB 0.652 0.052 -2 0.523
DNAPKDNAPK 0.650 0.025 1 0.447
PRP4PRP4 0.650 0.194 -3 0.619
NIKNIK 0.650 0.003 -3 0.751
AKT2AKT2 0.650 0.066 -3 0.646
PASKPASK 0.650 0.167 -3 0.785
PKCAPKCA 0.649 0.042 2 0.615
MPSK1MPSK1 0.649 0.098 1 0.518
PKCBPKCB 0.649 0.018 2 0.621
IKKAIKKA 0.649 0.001 -2 0.603
SMG1SMG1 0.649 0.021 1 0.485
PKCGPKCG 0.648 0.013 2 0.617
PDHK1PDHK1 0.648 -0.088 1 0.452
IKKEIKKE 0.648 -0.095 1 0.335
MLK2MLK2 0.648 0.019 2 0.675
P70S6KBP70S6KB 0.648 0.018 -3 0.708
PKACGPKACG 0.648 -0.001 -2 0.574
MARK4MARK4 0.648 -0.074 4 0.315
CAMK2BCAMK2B 0.648 0.028 2 0.652
MLK3MLK3 0.648 0.015 2 0.632
MSK1MSK1 0.647 0.046 -3 0.685
LATS1LATS1 0.647 0.088 -3 0.777
PRKD3PRKD3 0.647 0.032 -3 0.689
TBK1TBK1 0.647 -0.116 1 0.336
PRKXPRKX 0.646 0.049 -3 0.632
BMPR2BMPR2 0.646 -0.155 -2 0.687
AMPKA1AMPKA1 0.646 -0.051 -3 0.748
BCKDKBCKDK 0.646 -0.089 -1 0.627
ULK2ULK2 0.646 -0.118 2 0.610
NEK7NEK7 0.646 -0.108 -3 0.776
TSSK1TSSK1 0.645 -0.013 -3 0.764
MASTLMASTL 0.645 -0.029 -2 0.641
PIM2PIM2 0.645 0.064 -3 0.682
GCN2GCN2 0.645 -0.161 2 0.663
GRK5GRK5 0.645 -0.045 -3 0.704
MLK1MLK1 0.645 -0.090 2 0.688
IRE1IRE1 0.645 -0.075 1 0.484
AMPKA2AMPKA2 0.645 -0.027 -3 0.727
GRK7GRK7 0.645 0.035 1 0.389
RIPK1RIPK1 0.644 -0.096 1 0.442
GRK6GRK6 0.644 -0.040 1 0.385
HUNKHUNK 0.643 -0.129 2 0.644
MSK2MSK2 0.643 0.007 -3 0.695
PKCZPKCZ 0.642 -0.011 2 0.648
PAK1PAK1 0.642 -0.016 -2 0.644
PKG2PKG2 0.642 0.016 -2 0.522
QSKQSK 0.641 -0.041 4 0.316
FAM20CFAM20C 0.641 -0.026 2 0.505
TSSK2TSSK2 0.641 -0.035 -5 0.780
PHKG1PHKG1 0.641 -0.022 -3 0.726
PAK6PAK6 0.641 0.019 -2 0.555
SGK3SGK3 0.641 0.024 -3 0.688
NUAK1NUAK1 0.641 -0.021 -3 0.703
AKT3AKT3 0.641 0.090 -3 0.610
MNK1MNK1 0.640 0.006 -2 0.632
TGFBR2TGFBR2 0.640 -0.072 -2 0.573
NEK9NEK9 0.640 -0.098 2 0.699
ATMATM 0.640 -0.059 1 0.454
PAK3PAK3 0.640 -0.031 -2 0.640
DLKDLK 0.640 -0.068 1 0.408
PKRPKR 0.639 -0.041 1 0.489
BMPR1BBMPR1B 0.639 -0.016 1 0.351
WNK3WNK3 0.638 -0.196 1 0.432
IRE2IRE2 0.638 -0.055 2 0.583
TLK2TLK2 0.638 -0.002 1 0.459
ANKRD3ANKRD3 0.638 -0.084 1 0.451
VRK2VRK2 0.638 0.026 1 0.537
PKCHPKCH 0.638 -0.022 2 0.590
MYLK4MYLK4 0.637 -0.017 -2 0.614
MNK2MNK2 0.635 -0.043 -2 0.633
AURBAURB 0.635 -0.013 -2 0.498
MELKMELK 0.635 -0.037 -3 0.711
AKT1AKT1 0.635 0.036 -3 0.657
TTBK2TTBK2 0.635 -0.104 2 0.562
NIM1NIM1 0.635 -0.103 3 0.336
NEK2NEK2 0.634 -0.067 2 0.690
MARK3MARK3 0.634 -0.072 4 0.268
SIKSIK 0.633 -0.050 -3 0.677
ULK1ULK1 0.633 -0.126 -3 0.719
MLK4MLK4 0.633 -0.044 2 0.601
PINK1PINK1 0.633 0.041 1 0.635
CAMK4CAMK4 0.632 -0.062 -3 0.712
CHK1CHK1 0.632 0.032 -3 0.718
ALK4ALK4 0.632 -0.040 -2 0.643
CK1ECK1E 0.631 -0.011 -3 0.487
YSK4YSK4 0.631 -0.045 1 0.367
TGFBR1TGFBR1 0.631 -0.038 -2 0.619
SBKSBK 0.631 0.118 -3 0.556
MST3MST3 0.630 -0.018 2 0.744
PKACAPKACA 0.630 0.022 -2 0.478
QIKQIK 0.630 -0.120 -3 0.736
CAMK1GCAMK1G 0.630 -0.027 -3 0.686
GRK4GRK4 0.630 -0.111 -2 0.633
PAK2PAK2 0.629 -0.054 -2 0.617
PKCEPKCE 0.628 0.007 2 0.613
PKCTPKCT 0.628 -0.029 2 0.592
CHAK1CHAK1 0.628 -0.129 2 0.626
WNK4WNK4 0.628 -0.101 -2 0.745
LKB1LKB1 0.628 0.059 -3 0.729
IRAK4IRAK4 0.627 -0.090 1 0.457
DCAMKL1DCAMKL1 0.627 -0.008 -3 0.703
MAPKAPK5MAPKAPK5 0.627 -0.039 -3 0.665
SSTKSSTK 0.627 -0.046 4 0.315
BRSK1BRSK1 0.627 -0.060 -3 0.704
MEK1MEK1 0.627 -0.106 2 0.678
NEK5NEK5 0.626 -0.049 1 0.453
SGK1SGK1 0.626 0.051 -3 0.586
PKCIPKCI 0.626 -0.021 2 0.634
CK1DCK1D 0.626 0.009 -3 0.444
BUB1BUB1 0.625 0.058 -5 0.703
DRAK1DRAK1 0.625 -0.086 1 0.320
BRSK2BRSK2 0.625 -0.085 -3 0.711
SMMLCKSMMLCK 0.625 -0.021 -3 0.727
MARK2MARK2 0.625 -0.105 4 0.242
P70S6KP70S6K 0.624 0.010 -3 0.647
SNRKSNRK 0.623 -0.119 2 0.505
CK1A2CK1A2 0.623 -0.005 -3 0.446
PKN1PKN1 0.623 0.009 -3 0.664
AURAAURA 0.623 -0.033 -2 0.468
PAK4PAK4 0.623 0.002 -2 0.489
GAKGAK 0.623 0.018 1 0.465
ALK2ALK2 0.622 -0.071 -2 0.616
PLK1PLK1 0.622 -0.120 -2 0.585
ACVR2BACVR2B 0.622 -0.069 -2 0.593
PLK3PLK3 0.622 -0.089 2 0.608
CK2A2CK2A2 0.622 -0.031 1 0.289
MEKK1MEKK1 0.622 -0.117 1 0.423
MEK5MEK5 0.621 -0.120 2 0.663
CK1G1CK1G1 0.621 -0.033 -3 0.467
GRK2GRK2 0.621 -0.066 -2 0.558
TLK1TLK1 0.621 -0.095 -2 0.644
DAPK3DAPK3 0.621 -0.014 -3 0.715
BRAFBRAF 0.620 -0.061 -4 0.774
ACVR2AACVR2A 0.620 -0.079 -2 0.567
MARK1MARK1 0.620 -0.113 4 0.283
PLK4PLK4 0.619 -0.093 2 0.443
PDK1PDK1 0.619 -0.009 1 0.436
ZAKZAK 0.618 -0.108 1 0.378
DCAMKL2DCAMKL2 0.618 -0.029 -3 0.719
MRCKBMRCKB 0.618 0.012 -3 0.657
DAPK1DAPK1 0.618 -0.008 -3 0.705
PAK5PAK5 0.618 -0.024 -2 0.491
MEKK2MEKK2 0.618 -0.102 2 0.645
PDHK3_TYRPDHK3_TYR 0.617 0.218 4 0.375
NEK11NEK11 0.617 -0.079 1 0.399
TAO3TAO3 0.617 -0.067 1 0.416
BMPR1ABMPR1A 0.617 -0.056 1 0.326
PHKG2PHKG2 0.617 -0.089 -3 0.688
PERKPERK 0.617 -0.129 -2 0.614
CAMK1DCAMK1D 0.617 -0.010 -3 0.629
CAMKK2CAMKK2 0.616 -0.003 -2 0.614
DMPK1DMPK1 0.616 0.047 -3 0.678
CK2A1CK2A1 0.616 -0.035 1 0.267
GCKGCK 0.616 -0.014 1 0.397
MAP3K15MAP3K15 0.615 -0.042 1 0.389
CRIKCRIK 0.615 0.064 -3 0.671
ROCK2ROCK2 0.615 0.013 -3 0.702
MEKK6MEKK6 0.614 -0.071 1 0.431
NEK4NEK4 0.613 -0.075 1 0.416
YANK3YANK3 0.613 0.004 2 0.301
CHK2CHK2 0.612 0.003 -3 0.598
LRRK2LRRK2 0.612 -0.026 2 0.707
CAMKK1CAMKK1 0.612 -0.078 -2 0.621
MEKK3MEKK3 0.612 -0.166 1 0.406
PDHK4_TYRPDHK4_TYR 0.612 0.136 2 0.722
KHS1KHS1 0.611 -0.014 1 0.405
NEK8NEK8 0.611 -0.101 2 0.674
HRIHRI 0.611 -0.186 -2 0.634
TTBK1TTBK1 0.611 -0.106 2 0.472
GRK3GRK3 0.611 -0.065 -2 0.524
PBKPBK 0.611 0.011 1 0.442
HPK1HPK1 0.611 -0.039 1 0.388
TAK1TAK1 0.610 -0.030 1 0.416
LIMK2_TYRLIMK2_TYR 0.610 0.123 -3 0.764
MRCKAMRCKA 0.610 -0.000 -3 0.670
PLK2PLK2 0.610 -0.030 -3 0.635
TNIKTNIK 0.609 -0.050 3 0.351
EEF2KEEF2K 0.609 -0.070 3 0.373
CAMK1ACAMK1A 0.609 0.001 -3 0.609
TESK1_TYRTESK1_TYR 0.609 0.095 3 0.404
HGKHGK 0.609 -0.061 3 0.366
KHS2KHS2 0.608 -0.022 1 0.410
NEK1NEK1 0.608 -0.072 1 0.423
STK33STK33 0.608 -0.061 2 0.459
HASPINHASPIN 0.608 -0.012 -1 0.569
IRAK1IRAK1 0.608 -0.180 -1 0.582
TAO2TAO2 0.607 -0.113 2 0.702
PKMYT1_TYRPKMYT1_TYR 0.606 0.060 3 0.401
MINKMINK 0.606 -0.096 1 0.393
LOKLOK 0.605 -0.047 -2 0.577
MAP2K4_TYRMAP2K4_TYR 0.605 0.100 -1 0.692
SLKSLK 0.605 -0.037 -2 0.520
MAP2K6_TYRMAP2K6_TYR 0.603 0.053 -1 0.707
VRK1VRK1 0.602 -0.147 2 0.663
YSK1YSK1 0.602 -0.072 2 0.697
BMPR2_TYRBMPR2_TYR 0.601 0.040 -1 0.719
PDHK1_TYRPDHK1_TYR 0.601 0.040 -1 0.712
MST2MST2 0.601 -0.108 1 0.394
PKG1PKG1 0.600 -0.029 -2 0.461
EPHA6EPHA6 0.599 -0.017 -1 0.696
ROCK1ROCK1 0.598 -0.021 -3 0.663
MAP2K7_TYRMAP2K7_TYR 0.598 -0.068 2 0.694
NEK3NEK3 0.597 -0.084 1 0.419
TNK2TNK2 0.594 -0.026 3 0.357
MYO3BMYO3B 0.594 -0.051 2 0.706
MST1MST1 0.593 -0.112 1 0.387
PINK1_TYRPINK1_TYR 0.593 -0.146 1 0.468
RIPK2RIPK2 0.592 -0.188 1 0.347
RETRET 0.592 -0.121 1 0.444
DDR1DDR1 0.592 -0.101 4 0.328
MST1RMST1R 0.591 -0.125 3 0.353
BIKEBIKE 0.590 -0.027 1 0.417
LIMK1_TYRLIMK1_TYR 0.590 -0.088 2 0.684
AAK1AAK1 0.590 0.021 1 0.392
CK1ACK1A 0.590 -0.032 -3 0.365
FGRFGR 0.589 -0.035 1 0.418
OSR1OSR1 0.588 -0.080 2 0.661
ASK1ASK1 0.588 -0.079 1 0.373
JAK2JAK2 0.588 -0.122 1 0.442
EPHB4EPHB4 0.588 -0.089 -1 0.655
DDR2DDR2 0.587 -0.045 3 0.373
ROS1ROS1 0.587 -0.127 3 0.311
MEK2MEK2 0.587 -0.178 2 0.644
TTKTTK 0.587 -0.112 -2 0.597
CSF1RCSF1R 0.587 -0.125 3 0.336
TNK1TNK1 0.587 -0.060 3 0.318
FGFR2FGFR2 0.586 -0.059 3 0.396
TYK2TYK2 0.586 -0.201 1 0.436
TNNI3K_TYRTNNI3K_TYR 0.585 -0.029 1 0.490
KDRKDR 0.584 -0.081 3 0.328
LCKLCK 0.584 -0.082 -1 0.684
YES1YES1 0.584 -0.110 -1 0.681
TEKTEK 0.583 -0.045 3 0.322
EPHA4EPHA4 0.583 -0.053 2 0.625
TYRO3TYRO3 0.583 -0.159 3 0.328
MYO3AMYO3A 0.583 -0.092 1 0.431
JAK3JAK3 0.583 -0.124 1 0.415
JAK1JAK1 0.583 -0.077 1 0.388
ABL2ABL2 0.582 -0.130 -1 0.604
YANK2YANK2 0.582 -0.016 2 0.309
BLKBLK 0.581 -0.089 -1 0.677
FERFER 0.580 -0.145 1 0.421
HCKHCK 0.580 -0.129 -1 0.670
TXKTXK 0.580 -0.057 1 0.360
ALPHAK3ALPHAK3 0.580 -0.072 -1 0.608
ABL1ABL1 0.579 -0.130 -1 0.593
FGFR1FGFR1 0.579 -0.081 3 0.351
FYNFYN 0.578 -0.056 -1 0.696
KITKIT 0.578 -0.133 3 0.356
INSRRINSRR 0.578 -0.157 3 0.340
METMET 0.578 -0.108 3 0.344
EPHB1EPHB1 0.577 -0.124 1 0.390
WEE1_TYRWEE1_TYR 0.577 -0.085 -1 0.592
EPHB3EPHB3 0.577 -0.102 -1 0.643
NEK10_TYRNEK10_TYR 0.577 -0.092 1 0.356
TAO1TAO1 0.576 -0.139 1 0.374
SRMSSRMS 0.576 -0.125 1 0.383
EPHA7EPHA7 0.576 -0.073 2 0.609
FGFR3FGFR3 0.576 -0.079 3 0.381
ALKALK 0.574 -0.140 3 0.327
ITKITK 0.573 -0.134 -1 0.630
LTKLTK 0.572 -0.135 3 0.344
AXLAXL 0.572 -0.142 3 0.346
PDGFRBPDGFRB 0.572 -0.201 3 0.346
FLT1FLT1 0.572 -0.082 -1 0.666
LYNLYN 0.572 -0.107 3 0.327
EPHA3EPHA3 0.572 -0.097 2 0.589
EPHA1EPHA1 0.571 -0.132 3 0.326
MERTKMERTK 0.571 -0.147 3 0.332
BMXBMX 0.570 -0.113 -1 0.564
EPHB2EPHB2 0.570 -0.143 -1 0.630
FLT3FLT3 0.570 -0.217 3 0.323
PDGFRAPDGFRA 0.570 -0.176 3 0.337
PTK6PTK6 0.569 -0.123 -1 0.561
PTK2PTK2 0.568 -0.029 -1 0.691
TECTEC 0.568 -0.150 -1 0.549
ERBB2ERBB2 0.567 -0.134 1 0.369
FLT4FLT4 0.566 -0.140 3 0.349
FRKFRK 0.566 -0.145 -1 0.652
SRCSRC 0.566 -0.098 -1 0.667
CK1G3CK1G3 0.566 -0.043 -3 0.324
EPHA8EPHA8 0.566 -0.085 -1 0.655
NTRK3NTRK3 0.564 -0.098 -1 0.609
BTKBTK 0.564 -0.214 -1 0.594
MATKMATK 0.563 -0.105 -1 0.545
INSRINSR 0.563 -0.176 3 0.322
NTRK1NTRK1 0.563 -0.184 -1 0.640
STLK3STLK3 0.563 -0.154 1 0.357
FGFR4FGFR4 0.562 -0.082 -1 0.583
EPHA5EPHA5 0.562 -0.123 2 0.595
PTK2BPTK2B 0.562 -0.117 -1 0.574
ERBB4ERBB4 0.561 -0.062 1 0.303
CK1G2CK1G2 0.560 -0.037 -3 0.398
EGFREGFR 0.560 -0.092 1 0.303
CSKCSK 0.560 -0.126 2 0.611
NTRK2NTRK2 0.559 -0.197 3 0.334
EPHA2EPHA2 0.559 -0.082 -1 0.619
SYKSYK 0.558 -0.058 -1 0.661
IGF1RIGF1R 0.553 -0.151 3 0.308
ZAP70ZAP70 0.550 -0.038 -1 0.593
MUSKMUSK 0.549 -0.141 1 0.310
FESFES 0.542 -0.136 -1 0.543