Motif 296 (n=122)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WZ62 | None | S246 | ochoa | Mannosyltransferase (EC 2.4.1.-) | None |
| A0A0J9YX86 | GOLGA8Q | Y539 | ochoa | Golgin A8 family member Q | None |
| A6NMD2 | GOLGA8J | Y539 | ochoa | Golgin subfamily A member 8J | None |
| A8CG34 | POM121C | S970 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| H3BQL2 | GOLGA8T | Y538 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | Y539 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | Y538 | ochoa | Golgin subfamily A member 8R | None |
| O00221 | NFKBIE | S161 | psp | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}. |
| O14514 | ADGRB1 | S1278 | ochoa | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}. |
| O14654 | IRS4 | S465 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14654 | IRS4 | S1185 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14965 | AURKA | S284 | psp | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O15027 | SEC16A | S1398 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15503 | INSIG1 | S43 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43379 | WDR62 | S1232 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60271 | SPAG9 | S1242 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60347 | TBC1D12 | S113 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O75688 | PPM1B | S195 | ochoa|psp | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O94819 | KBTBD11 | S316 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O95613 | PCNT | S2345 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P00519 | ABL1 | S1011 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P00533 | EGFR | S1166 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P00918 | CA2 | S151 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P02545 | LMNA | S616 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P02671 | FGA | S294 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P0CJ92 | GOLGA8H | Y539 | ochoa | Golgin subfamily A member 8H | None |
| P10636 | MAPT | S602 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P16066 | NPR1 | S542 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P16157 | ANK1 | S759 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P20719 | HOXA5 | S92 | ochoa | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
| P21333 | FLNA | S2284 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P27816 | MAP4 | S1002 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29350 | PTPN6 | S138 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P35269 | GTF2F1 | S431 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P35813 | PPM1A | S190 | ochoa | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| P37840 | SNCA | S87 | ochoa|psp | Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}. |
| P43243 | MATR3 | S41 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48634 | PRRC2A | S193 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P55273 | CDKN2D | S66 | psp | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}. |
| P55735 | SEC13 | S166 | ochoa | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P78344 | EIF4G2 | S22 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q02952 | AKAP12 | S1483 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q04637 | EIF4G1 | S1077 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04725 | TLE2 | S193 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q06587 | RING1 | S190 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q09666 | AHNAK | S407 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13263 | TRIM28 | S598 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13263 | TRIM28 | S600 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13428 | TCOF1 | S1102 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | S107 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q14315 | FLNC | S1396 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14761 | PTPRCAP | S178 | ochoa | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q15582 | TGFBI | S37 | ochoa | Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) | Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). {ECO:0000250|UniProtKB:O11780, ECO:0000269|PubMed:8024701}. |
| Q16584 | MAP3K11 | S555 | psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q5SYE7 | NHSL1 | S1555 | ochoa | NHS-like protein 1 | None |
| Q5T4S7 | UBR4 | S2912 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5VT52 | RPRD2 | S1134 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S1136 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q6PJ61 | FBXO46 | S189 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6WKZ4 | RAB11FIP1 | S758 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q7Z6L1 | TECPR1 | S388 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86U28 | ISCA2 | S29 | ochoa | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:22323289}. |
| Q86W50 | METTL16 | S453 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q86XL3 | ANKLE2 | S872 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YV5 | PRAG1 | S231 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IWE5 | PLEKHM2 | S357 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8IWU2 | LMTK2 | S1397 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IZD0 | SAMD14 | S57 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8N3U4 | STAG2 | S1068 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8N556 | AFAP1 | S510 | ochoa | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) | Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}. |
| Q8N5A5 | ZGPAT | S99 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N8Z6 | DCBLD1 | S556 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NE01 | CNNM3 | S599 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NHG8 | ZNRF2 | S21 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8NHG8 | ZNRF2 | S107 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TEK3 | DOT1L | S1083 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WWH5 | TRUB1 | S134 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WX93 | PALLD | S725 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q92619 | ARHGAP45 | S90 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q96C90 | PPP1R14B | S21 | ochoa | Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein) | Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}. |
| Q96CP6 | GRAMD1A | S271 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96D05 | FAM241B | S28 | ochoa | Protein FAM241B | May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}. |
| Q96FF7 | MISP3 | S91 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96HC4 | PDLIM5 | S211 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96JH8 | RADIL | S963 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96RG2 | PASK | S584 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q99700 | ATXN2 | S217 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99856 | ARID3A | S81 | ochoa | AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) | Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}. |
| Q9BR76 | CORO1B | S423 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BW71 | HIRIP3 | S357 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BW71 | HIRIP3 | S502 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BWC9 | CCDC106 | S147 | psp | Coiled-coil domain-containing protein 106 | Promotes the degradation of p53/TP53 protein and inhibits its transactivity. {ECO:0000269|PubMed:20159018}. |
| Q9C0B5 | ZDHHC5 | S577 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S966 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1178 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0U4 | RAB1B | S179 | ochoa | Ras-related protein Rab-1B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}. |
| Q9H6W3 | RIOX1 | S63 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H9G7 | AGO3 | S829 | ochoa | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648, ECO:0000269|PubMed:29040713}. |
| Q9HBL0 | TNS1 | S1393 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9P2F8 | SIPA1L2 | S1286 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBY9 | HSPB7 | S54 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
| Q9UHK0 | NUFIP1 | S314 | ochoa | FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) | Binds RNA. {ECO:0000269|PubMed:10556305}. |
| Q9UHL9 | GTF2IRD1 | S471 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UI08 | EVL | S246 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UKK3 | PARP4 | S1491 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKV8 | AGO2 | S828 | ochoa|psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9UL18 | AGO1 | S826 | ochoa | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:18771919}. |
| Q9ULX9 | MAFF | S146 | ochoa | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}. |
| Q9Y3S1 | WNK2 | S45 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y490 | TLN1 | S1055 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4H2 | IRS2 | S388 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| P36578 | RPL4 | S63 | Sugiyama | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q9C0C2 | TNKS1BP1 | S1051 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| Q5T4S7 | UBR4 | S2932 | EPSD|PSP | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| P35637 | FUS | S360 | Sugiyama | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| Q14697 | GANAB | S913 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| P10412 | H1-4 | S86 | Sugiyama | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16401 | H1-5 | S89 | Sugiyama | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S87 | Sugiyama | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S86 | Sugiyama | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q02539 | H1-1 | S89 | Sugiyama | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P13798 | APEH | S94 | Sugiyama | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 9.024617e-08 | 7.045 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 3.882260e-07 | 6.411 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 3.363115e-07 | 6.473 |
| R-HSA-75153 | Apoptotic execution phase | 3.513277e-07 | 6.454 |
| R-HSA-2559583 | Cellular Senescence | 7.743089e-07 | 6.111 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.047694e-06 | 5.980 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.606394e-06 | 5.794 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 2.308924e-06 | 5.637 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 5.945891e-06 | 5.226 |
| R-HSA-211000 | Gene Silencing by RNA | 6.492214e-06 | 5.188 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.870168e-06 | 5.231 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 7.295401e-06 | 5.137 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.584738e-05 | 4.800 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.955123e-05 | 4.709 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.538663e-05 | 4.595 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.449296e-05 | 4.462 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 5.645275e-05 | 4.248 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.297702e-05 | 4.276 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.755177e-05 | 4.240 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.755177e-05 | 4.240 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 6.563186e-05 | 4.183 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 9.970246e-05 | 4.001 |
| R-HSA-68875 | Mitotic Prophase | 1.196077e-04 | 3.922 |
| R-HSA-9839394 | TGFBR3 expression | 1.285756e-04 | 3.891 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 1.285756e-04 | 3.891 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.193156e-04 | 3.923 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.450814e-04 | 3.838 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.018271e-04 | 3.695 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.037921e-04 | 3.691 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.668138e-04 | 3.574 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.064691e-04 | 3.514 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.064691e-04 | 3.514 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.390604e-04 | 3.470 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.046146e-04 | 3.393 |
| R-HSA-913531 | Interferon Signaling | 4.661215e-04 | 3.332 |
| R-HSA-109581 | Apoptosis | 6.962147e-04 | 3.157 |
| R-HSA-2262752 | Cellular responses to stress | 7.079678e-04 | 3.150 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.923509e-04 | 3.101 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.263076e-04 | 3.033 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.823869e-04 | 3.008 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.026455e-03 | 2.989 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.115492e-03 | 2.953 |
| R-HSA-8939211 | ESR-mediated signaling | 1.221583e-03 | 2.913 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.390764e-03 | 2.857 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.438570e-03 | 2.842 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.507524e-03 | 2.822 |
| R-HSA-68886 | M Phase | 1.683150e-03 | 2.774 |
| R-HSA-1500931 | Cell-Cell communication | 1.716058e-03 | 2.765 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.126925e-03 | 2.672 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.013301e-03 | 2.696 |
| R-HSA-5357801 | Programmed Cell Death | 2.467627e-03 | 2.608 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.494251e-03 | 2.603 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.235083e-03 | 2.490 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.085789e-03 | 2.511 |
| R-HSA-446728 | Cell junction organization | 3.039486e-03 | 2.517 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.491786e-03 | 2.457 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.491786e-03 | 2.457 |
| R-HSA-204005 | COPII-mediated vesicle transport | 3.853535e-03 | 2.414 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.516236e-03 | 2.454 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.620288e-03 | 2.441 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.041738e-03 | 2.393 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.041738e-03 | 2.393 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.335325e-03 | 2.363 |
| R-HSA-2025928 | Calcineurin activates NFAT | 4.370564e-03 | 2.359 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.335325e-03 | 2.363 |
| R-HSA-4086398 | Ca2+ pathway | 4.399587e-03 | 2.357 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.641534e-03 | 2.333 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.882247e-03 | 2.311 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.882247e-03 | 2.311 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.960518e-03 | 2.304 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.205686e-03 | 2.284 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.637395e-03 | 2.249 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.995565e-03 | 2.222 |
| R-HSA-157118 | Signaling by NOTCH | 5.394788e-03 | 2.268 |
| R-HSA-977225 | Amyloid fiber formation | 6.105250e-03 | 2.214 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 6.367062e-03 | 2.196 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 6.752012e-03 | 2.171 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.150531e-03 | 2.146 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.102759e-03 | 2.149 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.752012e-03 | 2.171 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 6.752012e-03 | 2.171 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 7.150531e-03 | 2.146 |
| R-HSA-1640170 | Cell Cycle | 6.265971e-03 | 2.203 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 6.367062e-03 | 2.196 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 7.150531e-03 | 2.146 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 7.102759e-03 | 2.149 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 7.639585e-03 | 2.117 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.832544e-03 | 2.007 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.832544e-03 | 2.007 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.832544e-03 | 2.007 |
| R-HSA-9609690 | HCMV Early Events | 8.297249e-03 | 2.081 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.832544e-03 | 2.007 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 9.350428e-03 | 2.029 |
| R-HSA-6807070 | PTEN Regulation | 9.007375e-03 | 2.045 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.031700e-03 | 2.044 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 9.528848e-03 | 2.021 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 8.544163e-03 | 2.068 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 9.832544e-03 | 2.007 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.297249e-03 | 2.081 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 9.096772e-03 | 2.041 |
| R-HSA-381070 | IRE1alpha activates chaperones | 9.408432e-03 | 2.026 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.056155e-02 | 1.976 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.126535e-02 | 1.948 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.164145e-02 | 1.934 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.164145e-02 | 1.934 |
| R-HSA-68882 | Mitotic Anaphase | 1.267806e-02 | 1.897 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.276773e-02 | 1.894 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.289276e-02 | 1.890 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.292049e-02 | 1.889 |
| R-HSA-418990 | Adherens junctions interactions | 1.316615e-02 | 1.881 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.357309e-02 | 1.867 |
| R-HSA-1221632 | Meiotic synapsis | 1.361027e-02 | 1.866 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.393959e-02 | 1.856 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.515623e-02 | 1.819 |
| R-HSA-191859 | snRNP Assembly | 1.741999e-02 | 1.759 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.741999e-02 | 1.759 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.442619e-02 | 1.841 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.516675e-02 | 1.819 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.748590e-02 | 1.757 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.952559e-02 | 1.709 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.988459e-02 | 1.701 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.058904e-02 | 1.686 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.176577e-02 | 1.662 |
| R-HSA-168255 | Influenza Infection | 2.278396e-02 | 1.642 |
| R-HSA-9609646 | HCMV Infection | 2.285945e-02 | 1.641 |
| R-HSA-421270 | Cell-cell junction organization | 2.322315e-02 | 1.634 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.335329e-02 | 1.632 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 2.393036e-02 | 1.621 |
| R-HSA-429947 | Deadenylation of mRNA | 2.486198e-02 | 1.604 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.510018e-02 | 1.600 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.558481e-02 | 1.592 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.579893e-02 | 1.588 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.799498e-02 | 1.553 |
| R-HSA-525793 | Myogenesis | 2.799498e-02 | 1.553 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.813384e-02 | 1.551 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.839831e-02 | 1.547 |
| R-HSA-114608 | Platelet degranulation | 2.864933e-02 | 1.543 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 3.178018e-02 | 1.498 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.297294e-02 | 1.482 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.699803e-02 | 1.432 |
| R-HSA-354192 | Integrin signaling | 4.010145e-02 | 1.397 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.418802e-02 | 1.466 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.329222e-02 | 1.478 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.207263e-02 | 1.494 |
| R-HSA-9008059 | Interleukin-37 signaling | 3.470377e-02 | 1.460 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.826868e-02 | 1.417 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.613154e-02 | 1.442 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.074346e-02 | 1.512 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.835035e-02 | 1.416 |
| R-HSA-1500620 | Meiosis | 4.012881e-02 | 1.397 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.142810e-02 | 1.383 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.142810e-02 | 1.383 |
| R-HSA-195721 | Signaling by WNT | 4.493702e-02 | 1.347 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.729236e-02 | 1.325 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.799294e-02 | 1.319 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.974293e-02 | 1.303 |
| R-HSA-1280218 | Adaptive Immune System | 4.984316e-02 | 1.302 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.029595e-02 | 1.298 |
| R-HSA-162587 | HIV Life Cycle | 5.418355e-02 | 1.266 |
| R-HSA-74713 | IRS activation | 5.495572e-02 | 1.260 |
| R-HSA-9927353 | Co-inhibition by BTLA | 5.495572e-02 | 1.260 |
| R-HSA-447038 | NrCAM interactions | 5.495572e-02 | 1.260 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.510177e-02 | 1.259 |
| R-HSA-9694548 | Maturation of spike protein | 5.799247e-02 | 1.237 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.012441e-02 | 1.221 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.012441e-02 | 1.221 |
| R-HSA-9683701 | Translation of Structural Proteins | 6.012441e-02 | 1.221 |
| R-HSA-70171 | Glycolysis | 6.159017e-02 | 1.210 |
| R-HSA-165159 | MTOR signalling | 6.228303e-02 | 1.206 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 6.255790e-02 | 1.204 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 6.255790e-02 | 1.204 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.424780e-02 | 1.192 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.009940e-02 | 1.154 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 7.009940e-02 | 1.154 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.758069e-02 | 1.110 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 7.758069e-02 | 1.110 |
| R-HSA-112412 | SOS-mediated signalling | 7.758069e-02 | 1.110 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 8.500225e-02 | 1.071 |
| R-HSA-9700645 | ALK mutants bind TKIs | 9.236455e-02 | 1.034 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 9.966807e-02 | 1.001 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 9.966807e-02 | 1.001 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.572283e-02 | 1.019 |
| R-HSA-198203 | PI3K/AKT activation | 9.966807e-02 | 1.001 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.891341e-02 | 1.162 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 9.966807e-02 | 1.001 |
| R-HSA-447043 | Neurofascin interactions | 7.009940e-02 | 1.154 |
| R-HSA-74749 | Signal attenuation | 9.966807e-02 | 1.001 |
| R-HSA-9683686 | Maturation of spike protein | 9.966807e-02 | 1.001 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.071846e-02 | 1.042 |
| R-HSA-447041 | CHL1 interactions | 7.758069e-02 | 1.110 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.667808e-02 | 1.176 |
| R-HSA-69236 | G1 Phase | 6.667808e-02 | 1.176 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.978245e-02 | 1.098 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.236455e-02 | 1.034 |
| R-HSA-2586552 | Signaling by Leptin | 9.966807e-02 | 1.001 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.236455e-02 | 1.034 |
| R-HSA-422475 | Axon guidance | 8.867822e-02 | 1.052 |
| R-HSA-70326 | Glucose metabolism | 9.043879e-02 | 1.044 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.667808e-02 | 1.176 |
| R-HSA-3371556 | Cellular response to heat stress | 9.678186e-02 | 1.014 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.000141e-01 | 1.000 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.016554e-01 | 0.993 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.025463e-01 | 0.989 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.025463e-01 | 0.989 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.052004e-01 | 0.978 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.061143e-01 | 0.974 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.061457e-01 | 0.974 |
| R-HSA-210990 | PECAM1 interactions | 1.069133e-01 | 0.971 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.076631e-01 | 0.968 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.137628e-01 | 0.944 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.141006e-01 | 0.943 |
| R-HSA-1474165 | Reproduction | 1.151157e-01 | 0.939 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.154631e-01 | 0.938 |
| R-HSA-9675108 | Nervous system development | 1.159116e-01 | 0.936 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.212305e-01 | 0.916 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.212305e-01 | 0.916 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.353200e-01 | 0.869 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.422805e-01 | 0.847 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.422805e-01 | 0.847 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.422805e-01 | 0.847 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.762575e-01 | 0.754 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.894712e-01 | 0.722 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.959990e-01 | 0.708 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.024746e-01 | 0.694 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.088984e-01 | 0.680 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.088984e-01 | 0.680 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.207413e-01 | 0.918 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.314705e-01 | 0.881 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.965339e-01 | 0.707 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.278635e-01 | 0.642 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.894712e-01 | 0.722 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.894712e-01 | 0.722 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.628300e-01 | 0.788 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.628300e-01 | 0.788 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.695706e-01 | 0.771 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.283035e-01 | 0.892 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.141399e-01 | 0.669 |
| R-HSA-180292 | GAB1 signalosome | 1.695706e-01 | 0.771 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.791283e-01 | 0.747 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.111941e-01 | 0.675 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.152709e-01 | 0.667 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.318888e-01 | 0.635 |
| R-HSA-4641265 | Repression of WNT target genes | 1.212305e-01 | 0.916 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.212305e-01 | 0.916 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.234026e-01 | 0.909 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.560350e-01 | 0.807 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 1.762575e-01 | 0.754 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.287676e-01 | 0.890 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.053156e-01 | 0.688 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.695706e-01 | 0.771 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.628300e-01 | 0.788 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.180947e-01 | 0.928 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.762575e-01 | 0.754 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.705200e-01 | 0.768 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.705200e-01 | 0.768 |
| R-HSA-162906 | HIV Infection | 1.403947e-01 | 0.853 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.212305e-01 | 0.916 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.762575e-01 | 0.754 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.369152e-01 | 0.864 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.762575e-01 | 0.754 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.024746e-01 | 0.694 |
| R-HSA-74160 | Gene expression (Transcription) | 1.206327e-01 | 0.919 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.499091e-01 | 0.824 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.212305e-01 | 0.916 |
| R-HSA-5578768 | Physiological factors | 1.353200e-01 | 0.869 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 1.828908e-01 | 0.738 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.088984e-01 | 0.680 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.152709e-01 | 0.667 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.283035e-01 | 0.892 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.828908e-01 | 0.738 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.648216e-01 | 0.783 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.962478e-01 | 0.707 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.024746e-01 | 0.694 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.495148e-01 | 0.825 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.353200e-01 | 0.869 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.491853e-01 | 0.826 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.024746e-01 | 0.694 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.283035e-01 | 0.892 |
| R-HSA-432142 | Platelet sensitization by LDL | 1.695706e-01 | 0.771 |
| R-HSA-9610379 | HCMV Late Events | 1.688143e-01 | 0.773 |
| R-HSA-9824446 | Viral Infection Pathways | 2.170135e-01 | 0.664 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.353200e-01 | 0.869 |
| R-HSA-9629569 | Protein hydroxylation | 1.828908e-01 | 0.738 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.560350e-01 | 0.807 |
| R-HSA-445144 | Signal transduction by L1 | 1.828908e-01 | 0.738 |
| R-HSA-212436 | Generic Transcription Pathway | 1.321667e-01 | 0.879 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.088984e-01 | 0.680 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.762575e-01 | 0.754 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.024746e-01 | 0.694 |
| R-HSA-8983711 | OAS antiviral response | 1.212305e-01 | 0.916 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.849042e-01 | 0.733 |
| R-HSA-9833482 | PKR-mediated signaling | 1.591587e-01 | 0.798 |
| R-HSA-168256 | Immune System | 1.269579e-01 | 0.896 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.152709e-01 | 0.667 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.152709e-01 | 0.667 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.418498e-01 | 0.848 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.141399e-01 | 0.669 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.215925e-01 | 0.654 |
| R-HSA-9679506 | SARS-CoV Infections | 1.853019e-01 | 0.732 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.206835e-01 | 0.918 |
| R-HSA-72306 | tRNA processing | 1.969431e-01 | 0.706 |
| R-HSA-5619102 | SLC transporter disorders | 1.887873e-01 | 0.724 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.340844e-01 | 0.631 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.340844e-01 | 0.631 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.340844e-01 | 0.631 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.340844e-01 | 0.631 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.340844e-01 | 0.631 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.340844e-01 | 0.631 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.378277e-01 | 0.624 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.402556e-01 | 0.619 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.402556e-01 | 0.619 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.402556e-01 | 0.619 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.402556e-01 | 0.619 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.402556e-01 | 0.619 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.402556e-01 | 0.619 |
| R-HSA-68877 | Mitotic Prometaphase | 2.452990e-01 | 0.610 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.463774e-01 | 0.608 |
| R-HSA-5334118 | DNA methylation | 2.463774e-01 | 0.608 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.463774e-01 | 0.608 |
| R-HSA-72086 | mRNA Capping | 2.463774e-01 | 0.608 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.463774e-01 | 0.608 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.524503e-01 | 0.598 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.524503e-01 | 0.598 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.524503e-01 | 0.598 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.524503e-01 | 0.598 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.527070e-01 | 0.597 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.527070e-01 | 0.597 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.527070e-01 | 0.597 |
| R-HSA-182971 | EGFR downregulation | 2.584746e-01 | 0.588 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.584746e-01 | 0.588 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.584746e-01 | 0.588 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.644507e-01 | 0.578 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.644507e-01 | 0.578 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.646292e-01 | 0.577 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.646292e-01 | 0.577 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.703790e-01 | 0.568 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.703790e-01 | 0.568 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.703790e-01 | 0.568 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.705920e-01 | 0.568 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.705920e-01 | 0.568 |
| R-HSA-390522 | Striated Muscle Contraction | 2.762599e-01 | 0.559 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.762599e-01 | 0.559 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.795342e-01 | 0.554 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.820938e-01 | 0.550 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.820938e-01 | 0.550 |
| R-HSA-5673000 | RAF activation | 2.820938e-01 | 0.550 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 2.820938e-01 | 0.550 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.820938e-01 | 0.550 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.820938e-01 | 0.550 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.825136e-01 | 0.549 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.825136e-01 | 0.549 |
| R-HSA-373760 | L1CAM interactions | 2.825136e-01 | 0.549 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.878810e-01 | 0.541 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.878810e-01 | 0.541 |
| R-HSA-5693538 | Homology Directed Repair | 2.884694e-01 | 0.540 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.884694e-01 | 0.540 |
| R-HSA-397014 | Muscle contraction | 2.887262e-01 | 0.540 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.936219e-01 | 0.532 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.936219e-01 | 0.532 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.936219e-01 | 0.532 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 2.936219e-01 | 0.532 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 2.936219e-01 | 0.532 |
| R-HSA-8853659 | RET signaling | 2.936219e-01 | 0.532 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.936219e-01 | 0.532 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.973928e-01 | 0.527 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 2.993169e-01 | 0.524 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.993169e-01 | 0.524 |
| R-HSA-110331 | Cleavage of the damaged purine | 2.993169e-01 | 0.524 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.033330e-01 | 0.518 |
| R-HSA-73927 | Depurination | 3.049663e-01 | 0.516 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.105705e-01 | 0.508 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.105705e-01 | 0.508 |
| R-HSA-201556 | Signaling by ALK | 3.105705e-01 | 0.508 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.122269e-01 | 0.506 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.122269e-01 | 0.506 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.122269e-01 | 0.506 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.161298e-01 | 0.500 |
| R-HSA-167169 | HIV Transcription Elongation | 3.161298e-01 | 0.500 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.161298e-01 | 0.500 |
| R-HSA-9646399 | Aggrephagy | 3.161298e-01 | 0.500 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 3.161298e-01 | 0.500 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.161298e-01 | 0.500 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.161298e-01 | 0.500 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.161298e-01 | 0.500 |
| R-HSA-5260271 | Diseases of Immune System | 3.161298e-01 | 0.500 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3.161298e-01 | 0.500 |
| R-HSA-202433 | Generation of second messenger molecules | 3.161298e-01 | 0.500 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.161298e-01 | 0.500 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.216447e-01 | 0.493 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 3.216447e-01 | 0.493 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.216447e-01 | 0.493 |
| R-HSA-1266738 | Developmental Biology | 3.231392e-01 | 0.491 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.269963e-01 | 0.485 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.271155e-01 | 0.485 |
| R-HSA-167161 | HIV Transcription Initiation | 3.271155e-01 | 0.485 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.271155e-01 | 0.485 |
| R-HSA-162582 | Signal Transduction | 3.296468e-01 | 0.482 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.325424e-01 | 0.478 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.325424e-01 | 0.478 |
| R-HSA-73928 | Depyrimidination | 3.325424e-01 | 0.478 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.379260e-01 | 0.471 |
| R-HSA-9710421 | Defective pyroptosis | 3.379260e-01 | 0.471 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.379260e-01 | 0.471 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.485641e-01 | 0.458 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.485641e-01 | 0.458 |
| R-HSA-774815 | Nucleosome assembly | 3.485641e-01 | 0.458 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.538194e-01 | 0.451 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.538194e-01 | 0.451 |
| R-HSA-1643685 | Disease | 3.605578e-01 | 0.443 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.642040e-01 | 0.439 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.656765e-01 | 0.437 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.693341e-01 | 0.433 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.693341e-01 | 0.433 |
| R-HSA-109704 | PI3K Cascade | 3.744231e-01 | 0.427 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 3.744231e-01 | 0.427 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.794713e-01 | 0.421 |
| R-HSA-912446 | Meiotic recombination | 3.794713e-01 | 0.421 |
| R-HSA-597592 | Post-translational protein modification | 3.806035e-01 | 0.420 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.822308e-01 | 0.418 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.844791e-01 | 0.415 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.844791e-01 | 0.415 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.844791e-01 | 0.415 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.844791e-01 | 0.415 |
| R-HSA-8953854 | Metabolism of RNA | 3.875485e-01 | 0.412 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.894468e-01 | 0.410 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.894468e-01 | 0.410 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.894468e-01 | 0.410 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.894468e-01 | 0.410 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.894468e-01 | 0.410 |
| R-HSA-72649 | Translation initiation complex formation | 3.943748e-01 | 0.404 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.943748e-01 | 0.404 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.992632e-01 | 0.399 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.992632e-01 | 0.399 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.992936e-01 | 0.399 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.992936e-01 | 0.399 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.992936e-01 | 0.399 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 4.021167e-01 | 0.396 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.041125e-01 | 0.393 |
| R-HSA-177929 | Signaling by EGFR | 4.041125e-01 | 0.393 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.041125e-01 | 0.393 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.049335e-01 | 0.393 |
| R-HSA-112399 | IRS-mediated signalling | 4.089229e-01 | 0.388 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.118731e-01 | 0.385 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.136948e-01 | 0.383 |
| R-HSA-9711097 | Cellular response to starvation | 4.161377e-01 | 0.381 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.231243e-01 | 0.374 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.231243e-01 | 0.374 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.231243e-01 | 0.374 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.231243e-01 | 0.374 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.231243e-01 | 0.374 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.324032e-01 | 0.364 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.327456e-01 | 0.364 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.369869e-01 | 0.360 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.369869e-01 | 0.360 |
| R-HSA-8848021 | Signaling by PTK6 | 4.369869e-01 | 0.360 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.369869e-01 | 0.360 |
| R-HSA-373755 | Semaphorin interactions | 4.369869e-01 | 0.360 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.415340e-01 | 0.355 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 4.415340e-01 | 0.355 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.505190e-01 | 0.346 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.544958e-01 | 0.342 |
| R-HSA-196807 | Nicotinate metabolism | 4.549576e-01 | 0.342 |
| R-HSA-199991 | Membrane Trafficking | 4.554766e-01 | 0.342 |
| R-HSA-167172 | Transcription of the HIV genome | 4.593606e-01 | 0.338 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.651933e-01 | 0.332 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.651933e-01 | 0.332 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.680609e-01 | 0.330 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.680609e-01 | 0.330 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.723589e-01 | 0.326 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.723589e-01 | 0.326 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.723589e-01 | 0.326 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.723589e-01 | 0.326 |
| R-HSA-109582 | Hemostasis | 4.752926e-01 | 0.323 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.766224e-01 | 0.322 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.808516e-01 | 0.318 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.850470e-01 | 0.314 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.850470e-01 | 0.314 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.850470e-01 | 0.314 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.850470e-01 | 0.314 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.862164e-01 | 0.313 |
| R-HSA-380287 | Centrosome maturation | 4.892088e-01 | 0.311 |
| R-HSA-8852135 | Protein ubiquitination | 4.892088e-01 | 0.311 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.892088e-01 | 0.311 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.933371e-01 | 0.307 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.933371e-01 | 0.307 |
| R-HSA-69275 | G2/M Transition | 4.939684e-01 | 0.306 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.990957e-01 | 0.302 |
| R-HSA-392499 | Metabolism of proteins | 5.000212e-01 | 0.301 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.014947e-01 | 0.300 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.014947e-01 | 0.300 |
| R-HSA-216083 | Integrin cell surface interactions | 5.014947e-01 | 0.300 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.055245e-01 | 0.296 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.095220e-01 | 0.293 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.095220e-01 | 0.293 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.095220e-01 | 0.293 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.134874e-01 | 0.289 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.142790e-01 | 0.289 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.251276e-01 | 0.280 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.290334e-01 | 0.277 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.328423e-01 | 0.273 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.328423e-01 | 0.273 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.328423e-01 | 0.273 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.364840e-01 | 0.270 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.366206e-01 | 0.270 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.366206e-01 | 0.270 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.403685e-01 | 0.267 |
| R-HSA-6798695 | Neutrophil degranulation | 5.411079e-01 | 0.267 |
| R-HSA-72172 | mRNA Splicing | 5.413241e-01 | 0.267 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.440864e-01 | 0.264 |
| R-HSA-156902 | Peptide chain elongation | 5.440864e-01 | 0.264 |
| R-HSA-9663891 | Selective autophagy | 5.440864e-01 | 0.264 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.477744e-01 | 0.261 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.514328e-01 | 0.259 |
| R-HSA-73884 | Base Excision Repair | 5.514328e-01 | 0.259 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.550619e-01 | 0.256 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.622328e-01 | 0.250 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.622328e-01 | 0.250 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.657752e-01 | 0.247 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.657752e-01 | 0.247 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.727747e-01 | 0.242 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.762324e-01 | 0.239 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.762324e-01 | 0.239 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.796623e-01 | 0.237 |
| R-HSA-157579 | Telomere Maintenance | 5.830647e-01 | 0.234 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.830647e-01 | 0.234 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.838666e-01 | 0.234 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.864397e-01 | 0.232 |
| R-HSA-190236 | Signaling by FGFR | 5.864397e-01 | 0.232 |
| R-HSA-3214847 | HATs acetylate histones | 5.897876e-01 | 0.229 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.931086e-01 | 0.227 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.964030e-01 | 0.224 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.964030e-01 | 0.224 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.996709e-01 | 0.222 |
| R-HSA-192823 | Viral mRNA Translation | 6.029125e-01 | 0.220 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.061280e-01 | 0.217 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.061280e-01 | 0.217 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.093178e-01 | 0.215 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.093178e-01 | 0.215 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.097068e-01 | 0.215 |
| R-HSA-418346 | Platelet homeostasis | 6.156205e-01 | 0.211 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.187340e-01 | 0.208 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.218224e-01 | 0.206 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.218224e-01 | 0.206 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.248859e-01 | 0.204 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.248859e-01 | 0.204 |
| R-HSA-202403 | TCR signaling | 6.279249e-01 | 0.202 |
| R-HSA-5663205 | Infectious disease | 6.341462e-01 | 0.198 |
| R-HSA-4839726 | Chromatin organization | 6.409066e-01 | 0.193 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.427571e-01 | 0.192 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.485243e-01 | 0.188 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.541991e-01 | 0.184 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.586754e-01 | 0.181 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.597830e-01 | 0.181 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.597830e-01 | 0.181 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.597830e-01 | 0.181 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.645386e-01 | 0.177 |
| R-HSA-73886 | Chromosome Maintenance | 6.652774e-01 | 0.177 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.679915e-01 | 0.175 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.679915e-01 | 0.175 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.706838e-01 | 0.173 |
| R-HSA-69481 | G2/M Checkpoints | 6.838235e-01 | 0.165 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.863883e-01 | 0.163 |
| R-HSA-5576891 | Cardiac conduction | 6.964428e-01 | 0.157 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.989061e-01 | 0.156 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.026479e-01 | 0.153 |
| R-HSA-72766 | Translation | 7.070636e-01 | 0.151 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.132744e-01 | 0.147 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.156021e-01 | 0.145 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.202013e-01 | 0.143 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.202013e-01 | 0.143 |
| R-HSA-9664407 | Parasite infection | 7.202013e-01 | 0.143 |
| R-HSA-1632852 | Macroautophagy | 7.224732e-01 | 0.141 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.224732e-01 | 0.141 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.291795e-01 | 0.137 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.400012e-01 | 0.131 |
| R-HSA-69242 | S Phase | 7.400012e-01 | 0.131 |
| R-HSA-166520 | Signaling by NTRKs | 7.400012e-01 | 0.131 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.423079e-01 | 0.129 |
| R-HSA-69306 | DNA Replication | 7.503937e-01 | 0.125 |
| R-HSA-9612973 | Autophagy | 7.564302e-01 | 0.121 |
| R-HSA-877300 | Interferon gamma signaling | 7.623218e-01 | 0.118 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.642540e-01 | 0.117 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.718285e-01 | 0.112 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.845071e-01 | 0.105 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.897245e-01 | 0.103 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.914356e-01 | 0.102 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.139893e-01 | 0.089 |
| R-HSA-73894 | DNA Repair | 8.142539e-01 | 0.089 |
| R-HSA-983712 | Ion channel transport | 8.155044e-01 | 0.089 |
| R-HSA-5617833 | Cilium Assembly | 8.170072e-01 | 0.088 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.184979e-01 | 0.087 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.313831e-01 | 0.080 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.484085e-01 | 0.071 |
| R-HSA-168249 | Innate Immune System | 8.614086e-01 | 0.065 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.692003e-01 | 0.061 |
| R-HSA-72312 | rRNA processing | 8.713282e-01 | 0.060 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.764987e-01 | 0.057 |
| R-HSA-5688426 | Deubiquitination | 8.934625e-01 | 0.049 |
| R-HSA-449147 | Signaling by Interleukins | 8.971402e-01 | 0.047 |
| R-HSA-416476 | G alpha (q) signalling events | 9.010558e-01 | 0.045 |
| R-HSA-112316 | Neuronal System | 9.079375e-01 | 0.042 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.139632e-01 | 0.039 |
| R-HSA-9658195 | Leishmania infection | 9.139632e-01 | 0.039 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.376020e-01 | 0.028 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.391270e-01 | 0.027 |
| R-HSA-8957322 | Metabolism of steroids | 9.396271e-01 | 0.027 |
| R-HSA-1474244 | Extracellular matrix organization | 9.430153e-01 | 0.025 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.475307e-01 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.566134e-01 | 0.019 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.948245e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.977286e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.986148e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.993168e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999972e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.812 | 0.186 | 2 | 0.827 |
MTOR |
0.811 | 0.297 | 1 | 0.723 |
CLK3 |
0.804 | 0.141 | 1 | 0.722 |
CDC7 |
0.801 | 0.076 | 1 | 0.705 |
KIS |
0.800 | 0.133 | 1 | 0.658 |
MOS |
0.800 | 0.141 | 1 | 0.761 |
PIM3 |
0.799 | 0.085 | -3 | 0.779 |
HIPK4 |
0.799 | 0.132 | 1 | 0.748 |
PRKD1 |
0.798 | 0.109 | -3 | 0.760 |
MST4 |
0.798 | 0.163 | 2 | 0.838 |
NLK |
0.797 | 0.104 | 1 | 0.770 |
NDR2 |
0.796 | 0.083 | -3 | 0.782 |
ERK5 |
0.795 | 0.093 | 1 | 0.761 |
IKKB |
0.795 | 0.012 | -2 | 0.653 |
CDKL1 |
0.794 | 0.091 | -3 | 0.746 |
SRPK1 |
0.793 | 0.083 | -3 | 0.704 |
CDK18 |
0.793 | 0.161 | 1 | 0.594 |
NEK6 |
0.793 | 0.054 | -2 | 0.753 |
PRPK |
0.793 | 0.007 | -1 | 0.714 |
RAF1 |
0.793 | 0.050 | 1 | 0.764 |
CDKL5 |
0.793 | 0.092 | -3 | 0.733 |
TBK1 |
0.791 | 0.014 | 1 | 0.694 |
GCN2 |
0.790 | -0.046 | 2 | 0.788 |
PRKD2 |
0.790 | 0.060 | -3 | 0.693 |
SKMLCK |
0.790 | 0.088 | -2 | 0.788 |
WNK1 |
0.789 | 0.062 | -2 | 0.803 |
AURC |
0.789 | 0.083 | -2 | 0.594 |
ULK2 |
0.788 | -0.020 | 2 | 0.775 |
ICK |
0.788 | 0.105 | -3 | 0.776 |
IKKA |
0.788 | 0.052 | -2 | 0.653 |
IKKE |
0.788 | 0.002 | 1 | 0.698 |
DSTYK |
0.788 | 0.003 | 2 | 0.837 |
PKN2 |
0.788 | 0.067 | -3 | 0.786 |
GRK1 |
0.788 | 0.102 | -2 | 0.725 |
DYRK2 |
0.787 | 0.114 | 1 | 0.674 |
NDR1 |
0.787 | 0.036 | -3 | 0.764 |
CDK1 |
0.787 | 0.122 | 1 | 0.609 |
HIPK2 |
0.787 | 0.130 | 1 | 0.614 |
RSK2 |
0.787 | 0.047 | -3 | 0.694 |
CAMK1B |
0.786 | -0.014 | -3 | 0.787 |
PDHK4 |
0.786 | -0.069 | 1 | 0.768 |
ATR |
0.785 | -0.002 | 1 | 0.677 |
BCKDK |
0.785 | 0.021 | -1 | 0.730 |
PIM1 |
0.785 | 0.068 | -3 | 0.716 |
BMPR2 |
0.785 | -0.051 | -2 | 0.776 |
NEK7 |
0.785 | -0.028 | -3 | 0.809 |
CDK8 |
0.785 | 0.088 | 1 | 0.639 |
NUAK2 |
0.785 | 0.026 | -3 | 0.769 |
CDK5 |
0.785 | 0.131 | 1 | 0.663 |
PKN3 |
0.784 | 0.011 | -3 | 0.768 |
GRK5 |
0.784 | -0.014 | -3 | 0.838 |
PKCD |
0.784 | 0.093 | 2 | 0.774 |
GRK7 |
0.784 | 0.140 | 1 | 0.664 |
CDK19 |
0.784 | 0.098 | 1 | 0.607 |
JNK2 |
0.783 | 0.130 | 1 | 0.606 |
RIPK3 |
0.783 | -0.023 | 3 | 0.591 |
NIK |
0.782 | 0.019 | -3 | 0.816 |
PDHK1 |
0.782 | -0.069 | 1 | 0.765 |
RSK3 |
0.782 | 0.032 | -3 | 0.694 |
CHAK2 |
0.782 | -0.004 | -1 | 0.698 |
CDK13 |
0.782 | 0.085 | 1 | 0.628 |
P90RSK |
0.782 | 0.020 | -3 | 0.703 |
MPSK1 |
0.781 | 0.300 | 1 | 0.808 |
HIPK1 |
0.781 | 0.116 | 1 | 0.697 |
P38A |
0.781 | 0.127 | 1 | 0.688 |
CDK7 |
0.781 | 0.070 | 1 | 0.652 |
PKCA |
0.780 | 0.131 | 2 | 0.731 |
CAMLCK |
0.780 | 0.004 | -2 | 0.757 |
PKACG |
0.780 | 0.036 | -2 | 0.651 |
MLK1 |
0.780 | -0.033 | 2 | 0.796 |
P38B |
0.780 | 0.128 | 1 | 0.619 |
CDK17 |
0.779 | 0.115 | 1 | 0.542 |
MAPKAPK2 |
0.779 | 0.015 | -3 | 0.654 |
ERK1 |
0.779 | 0.100 | 1 | 0.620 |
SRPK2 |
0.779 | 0.044 | -3 | 0.612 |
BMPR1B |
0.779 | 0.088 | 1 | 0.689 |
CAMK2G |
0.779 | -0.068 | 2 | 0.744 |
AMPKA1 |
0.779 | 0.007 | -3 | 0.783 |
P38G |
0.779 | 0.110 | 1 | 0.542 |
MNK2 |
0.779 | 0.050 | -2 | 0.711 |
IRE1 |
0.778 | 0.019 | 1 | 0.713 |
NEK9 |
0.778 | -0.009 | 2 | 0.831 |
MARK4 |
0.778 | 0.053 | 4 | 0.790 |
CDK3 |
0.778 | 0.107 | 1 | 0.562 |
TGFBR2 |
0.778 | -0.038 | -2 | 0.692 |
PRP4 |
0.777 | 0.182 | -3 | 0.850 |
MLK2 |
0.777 | 0.022 | 2 | 0.801 |
PKCB |
0.777 | 0.082 | 2 | 0.735 |
NIM1 |
0.777 | 0.110 | 3 | 0.619 |
LATS2 |
0.777 | -0.017 | -5 | 0.670 |
JNK3 |
0.777 | 0.102 | 1 | 0.626 |
PKCG |
0.777 | 0.085 | 2 | 0.722 |
DAPK2 |
0.777 | -0.007 | -3 | 0.797 |
CAMK2D |
0.777 | 0.003 | -3 | 0.764 |
CDK12 |
0.776 | 0.090 | 1 | 0.601 |
HUNK |
0.776 | -0.062 | 2 | 0.794 |
MAPKAPK3 |
0.776 | -0.027 | -3 | 0.697 |
PKACB |
0.776 | 0.070 | -2 | 0.600 |
SRPK3 |
0.776 | 0.040 | -3 | 0.681 |
MLK3 |
0.775 | 0.030 | 2 | 0.728 |
GRK6 |
0.775 | -0.032 | 1 | 0.712 |
ULK1 |
0.775 | -0.112 | -3 | 0.773 |
CLK2 |
0.774 | 0.110 | -3 | 0.677 |
CDK16 |
0.774 | 0.132 | 1 | 0.560 |
CK1E |
0.774 | 0.102 | -3 | 0.577 |
PKR |
0.774 | 0.086 | 1 | 0.747 |
CDK14 |
0.774 | 0.123 | 1 | 0.637 |
P70S6KB |
0.774 | -0.015 | -3 | 0.716 |
PAK1 |
0.774 | 0.013 | -2 | 0.705 |
MASTL |
0.773 | -0.061 | -2 | 0.716 |
DLK |
0.773 | -0.067 | 1 | 0.726 |
RSK4 |
0.773 | 0.046 | -3 | 0.672 |
AMPKA2 |
0.773 | -0.007 | -3 | 0.749 |
RIPK1 |
0.773 | -0.073 | 1 | 0.711 |
TGFBR1 |
0.772 | 0.041 | -2 | 0.723 |
CLK4 |
0.772 | 0.044 | -3 | 0.692 |
FAM20C |
0.772 | 0.025 | 2 | 0.516 |
YSK4 |
0.772 | 0.036 | 1 | 0.724 |
SGK3 |
0.772 | 0.070 | -3 | 0.709 |
MAK |
0.772 | 0.178 | -2 | 0.732 |
ANKRD3 |
0.771 | -0.064 | 1 | 0.754 |
GRK4 |
0.771 | -0.047 | -2 | 0.735 |
PKCZ |
0.771 | 0.050 | 2 | 0.776 |
CLK1 |
0.771 | 0.047 | -3 | 0.665 |
TSSK2 |
0.771 | -0.041 | -5 | 0.816 |
MST3 |
0.771 | 0.174 | 2 | 0.821 |
TSSK1 |
0.771 | -0.011 | -3 | 0.796 |
NEK2 |
0.770 | 0.019 | 2 | 0.816 |
PRKD3 |
0.770 | -0.010 | -3 | 0.671 |
CDK9 |
0.770 | 0.057 | 1 | 0.631 |
AURB |
0.770 | 0.024 | -2 | 0.588 |
PRKX |
0.770 | 0.062 | -3 | 0.619 |
CDK10 |
0.769 | 0.108 | 1 | 0.622 |
CDK2 |
0.769 | 0.044 | 1 | 0.667 |
PAK3 |
0.769 | -0.025 | -2 | 0.695 |
WNK3 |
0.769 | -0.175 | 1 | 0.726 |
MSK2 |
0.769 | -0.013 | -3 | 0.683 |
LATS1 |
0.769 | 0.030 | -3 | 0.777 |
AKT2 |
0.768 | 0.042 | -3 | 0.617 |
TTBK2 |
0.768 | -0.085 | 2 | 0.676 |
DYRK4 |
0.767 | 0.083 | 1 | 0.611 |
HIPK3 |
0.767 | 0.068 | 1 | 0.696 |
MNK1 |
0.767 | 0.018 | -2 | 0.707 |
ALK4 |
0.767 | -0.012 | -2 | 0.743 |
PKCH |
0.767 | 0.029 | 2 | 0.726 |
GSK3A |
0.767 | 0.117 | 4 | 0.442 |
CAMK2A |
0.767 | -0.002 | 2 | 0.725 |
DYRK1A |
0.767 | 0.057 | 1 | 0.688 |
TLK2 |
0.767 | 0.020 | 1 | 0.700 |
PKG2 |
0.767 | 0.014 | -2 | 0.596 |
CK1G1 |
0.767 | 0.090 | -3 | 0.577 |
P38D |
0.767 | 0.102 | 1 | 0.542 |
PHKG1 |
0.767 | -0.035 | -3 | 0.749 |
TAO3 |
0.766 | 0.160 | 1 | 0.725 |
QSK |
0.766 | 0.037 | 4 | 0.772 |
CAMK2B |
0.766 | -0.005 | 2 | 0.700 |
MSK1 |
0.766 | 0.013 | -3 | 0.688 |
PAK6 |
0.766 | 0.007 | -2 | 0.627 |
AURA |
0.765 | 0.023 | -2 | 0.572 |
ERK2 |
0.765 | 0.038 | 1 | 0.643 |
VRK2 |
0.765 | -0.019 | 1 | 0.767 |
CK1D |
0.764 | 0.098 | -3 | 0.537 |
PLK4 |
0.764 | 0.026 | 2 | 0.623 |
NUAK1 |
0.764 | -0.045 | -3 | 0.699 |
PLK1 |
0.764 | -0.083 | -2 | 0.683 |
DYRK3 |
0.764 | 0.071 | 1 | 0.697 |
MEK1 |
0.764 | -0.043 | 2 | 0.809 |
QIK |
0.763 | -0.020 | -3 | 0.762 |
IRE2 |
0.762 | -0.046 | 2 | 0.746 |
DNAPK |
0.762 | 0.024 | 1 | 0.572 |
DYRK1B |
0.762 | 0.059 | 1 | 0.630 |
CAMK4 |
0.762 | -0.109 | -3 | 0.737 |
PIM2 |
0.762 | 0.025 | -3 | 0.668 |
MLK4 |
0.761 | -0.049 | 2 | 0.706 |
MYLK4 |
0.761 | -0.029 | -2 | 0.687 |
SMG1 |
0.761 | -0.071 | 1 | 0.629 |
DCAMKL1 |
0.761 | 0.023 | -3 | 0.708 |
MELK |
0.761 | -0.074 | -3 | 0.722 |
CK1A2 |
0.761 | 0.084 | -3 | 0.533 |
ACVR2B |
0.760 | -0.025 | -2 | 0.688 |
ZAK |
0.760 | 0.004 | 1 | 0.690 |
NEK5 |
0.760 | 0.051 | 1 | 0.732 |
ATM |
0.760 | -0.092 | 1 | 0.594 |
GRK2 |
0.760 | -0.016 | -2 | 0.645 |
PAK2 |
0.760 | -0.045 | -2 | 0.684 |
GAK |
0.759 | 0.187 | 1 | 0.819 |
ALK2 |
0.759 | -0.021 | -2 | 0.726 |
MEKK3 |
0.759 | -0.001 | 1 | 0.725 |
PINK1 |
0.759 | -0.044 | 1 | 0.798 |
JNK1 |
0.759 | 0.079 | 1 | 0.588 |
SIK |
0.758 | 0.004 | -3 | 0.680 |
ACVR2A |
0.758 | -0.042 | -2 | 0.676 |
MEKK2 |
0.758 | 0.043 | 2 | 0.789 |
LKB1 |
0.758 | 0.103 | -3 | 0.803 |
GCK |
0.758 | 0.189 | 1 | 0.756 |
MARK3 |
0.758 | 0.012 | 4 | 0.714 |
CHAK1 |
0.758 | -0.110 | 2 | 0.754 |
MEKK1 |
0.757 | -0.016 | 1 | 0.717 |
WNK4 |
0.757 | -0.023 | -2 | 0.792 |
PASK |
0.757 | 0.043 | -3 | 0.811 |
AKT1 |
0.757 | 0.039 | -3 | 0.637 |
GSK3B |
0.757 | 0.052 | 4 | 0.437 |
PKCT |
0.757 | 0.027 | 2 | 0.733 |
PKACA |
0.757 | 0.029 | -2 | 0.556 |
CHK1 |
0.756 | -0.057 | -3 | 0.726 |
MEK5 |
0.756 | -0.063 | 2 | 0.805 |
NEK11 |
0.756 | 0.063 | 1 | 0.716 |
ERK7 |
0.756 | 0.067 | 2 | 0.560 |
BRAF |
0.755 | -0.038 | -4 | 0.741 |
IRAK4 |
0.755 | -0.041 | 1 | 0.702 |
MINK |
0.754 | 0.159 | 1 | 0.745 |
HPK1 |
0.754 | 0.164 | 1 | 0.748 |
CDK6 |
0.754 | 0.077 | 1 | 0.621 |
BMPR1A |
0.754 | 0.009 | 1 | 0.655 |
TNIK |
0.753 | 0.149 | 3 | 0.724 |
PERK |
0.753 | -0.092 | -2 | 0.716 |
KHS2 |
0.753 | 0.189 | 1 | 0.753 |
MOK |
0.753 | 0.107 | 1 | 0.718 |
AKT3 |
0.753 | 0.054 | -3 | 0.567 |
BRSK1 |
0.753 | -0.078 | -3 | 0.716 |
PKCI |
0.753 | 0.019 | 2 | 0.748 |
PKCE |
0.752 | 0.047 | 2 | 0.717 |
TLK1 |
0.752 | -0.077 | -2 | 0.735 |
BRSK2 |
0.751 | -0.093 | -3 | 0.729 |
DRAK1 |
0.751 | -0.075 | 1 | 0.649 |
HRI |
0.751 | -0.144 | -2 | 0.724 |
HGK |
0.751 | 0.108 | 3 | 0.722 |
MAP3K15 |
0.751 | 0.112 | 1 | 0.688 |
CAMK1G |
0.751 | -0.056 | -3 | 0.676 |
MEKK6 |
0.751 | 0.095 | 1 | 0.721 |
CK2A2 |
0.751 | 0.025 | 1 | 0.623 |
GRK3 |
0.751 | -0.001 | -2 | 0.614 |
KHS1 |
0.750 | 0.176 | 1 | 0.740 |
MARK2 |
0.750 | -0.025 | 4 | 0.673 |
CDK4 |
0.749 | 0.056 | 1 | 0.592 |
SGK1 |
0.749 | 0.051 | -3 | 0.548 |
CAMKK1 |
0.749 | -0.053 | -2 | 0.658 |
NEK4 |
0.749 | 0.042 | 1 | 0.721 |
TAO2 |
0.748 | 0.016 | 2 | 0.833 |
PDK1 |
0.748 | 0.013 | 1 | 0.699 |
SSTK |
0.748 | -0.056 | 4 | 0.769 |
PLK3 |
0.748 | -0.133 | 2 | 0.711 |
MST2 |
0.748 | 0.057 | 1 | 0.736 |
PHKG2 |
0.747 | -0.075 | -3 | 0.717 |
DCAMKL2 |
0.747 | -0.050 | -3 | 0.716 |
PBK |
0.746 | 0.151 | 1 | 0.769 |
MAPKAPK5 |
0.746 | -0.132 | -3 | 0.642 |
TAK1 |
0.746 | 0.056 | 1 | 0.757 |
ROCK2 |
0.746 | 0.067 | -3 | 0.721 |
SMMLCK |
0.746 | -0.054 | -3 | 0.749 |
PAK5 |
0.746 | -0.022 | -2 | 0.568 |
P70S6K |
0.746 | -0.051 | -3 | 0.630 |
CAMKK2 |
0.745 | -0.038 | -2 | 0.659 |
SNRK |
0.745 | -0.181 | 2 | 0.673 |
PDHK3_TYR |
0.745 | 0.196 | 4 | 0.875 |
MARK1 |
0.745 | -0.051 | 4 | 0.738 |
NEK8 |
0.745 | -0.090 | 2 | 0.808 |
MRCKB |
0.744 | 0.027 | -3 | 0.667 |
EEF2K |
0.744 | 0.015 | 3 | 0.698 |
BUB1 |
0.744 | 0.048 | -5 | 0.732 |
NEK1 |
0.743 | 0.061 | 1 | 0.714 |
PAK4 |
0.743 | -0.017 | -2 | 0.583 |
DAPK3 |
0.741 | -0.015 | -3 | 0.727 |
YSK1 |
0.741 | 0.089 | 2 | 0.809 |
LOK |
0.741 | -0.004 | -2 | 0.657 |
LRRK2 |
0.741 | -0.009 | 2 | 0.834 |
CK2A1 |
0.741 | 0.012 | 1 | 0.604 |
MRCKA |
0.740 | 0.018 | -3 | 0.670 |
PKN1 |
0.738 | -0.034 | -3 | 0.642 |
TTBK1 |
0.738 | -0.144 | 2 | 0.593 |
PKMYT1_TYR |
0.738 | 0.185 | 3 | 0.707 |
DAPK1 |
0.737 | -0.015 | -3 | 0.719 |
MST1 |
0.737 | 0.007 | 1 | 0.726 |
MAP2K4_TYR |
0.737 | 0.160 | -1 | 0.746 |
PDHK4_TYR |
0.737 | 0.121 | 2 | 0.824 |
CAMK1D |
0.737 | -0.063 | -3 | 0.588 |
SLK |
0.737 | -0.025 | -2 | 0.607 |
IRAK1 |
0.736 | -0.195 | -1 | 0.603 |
TESK1_TYR |
0.736 | 0.031 | 3 | 0.740 |
CHK2 |
0.735 | -0.037 | -3 | 0.560 |
CK1A |
0.735 | 0.079 | -3 | 0.457 |
MAP2K6_TYR |
0.735 | 0.098 | -1 | 0.745 |
BMPR2_TYR |
0.734 | 0.081 | -1 | 0.750 |
DMPK1 |
0.734 | 0.040 | -3 | 0.685 |
VRK1 |
0.734 | -0.053 | 2 | 0.805 |
LIMK2_TYR |
0.733 | 0.073 | -3 | 0.829 |
OSR1 |
0.733 | 0.027 | 2 | 0.797 |
PDHK1_TYR |
0.732 | 0.049 | -1 | 0.737 |
STK33 |
0.732 | -0.096 | 2 | 0.590 |
SBK |
0.731 | -0.006 | -3 | 0.491 |
MAP2K7_TYR |
0.731 | -0.006 | 2 | 0.819 |
NEK3 |
0.731 | -0.015 | 1 | 0.680 |
CAMK1A |
0.731 | -0.046 | -3 | 0.588 |
MYO3B |
0.730 | 0.093 | 2 | 0.816 |
BIKE |
0.730 | 0.121 | 1 | 0.754 |
HASPIN |
0.730 | -0.005 | -1 | 0.590 |
ROCK1 |
0.729 | 0.027 | -3 | 0.678 |
CRIK |
0.727 | 0.012 | -3 | 0.637 |
PLK2 |
0.726 | -0.075 | -3 | 0.710 |
MEK2 |
0.725 | -0.133 | 2 | 0.792 |
PINK1_TYR |
0.724 | -0.135 | 1 | 0.751 |
MYO3A |
0.723 | 0.054 | 1 | 0.716 |
LIMK1_TYR |
0.723 | -0.054 | 2 | 0.828 |
AAK1 |
0.722 | 0.164 | 1 | 0.685 |
ASK1 |
0.722 | -0.017 | 1 | 0.678 |
TTK |
0.721 | -0.044 | -2 | 0.709 |
RIPK2 |
0.721 | -0.221 | 1 | 0.661 |
PKG1 |
0.720 | -0.050 | -2 | 0.518 |
TAO1 |
0.720 | -0.012 | 1 | 0.666 |
RET |
0.720 | -0.119 | 1 | 0.709 |
EPHA6 |
0.720 | -0.065 | -1 | 0.700 |
YANK3 |
0.718 | -0.032 | 2 | 0.357 |
ABL2 |
0.717 | -0.036 | -1 | 0.634 |
ABL1 |
0.717 | -0.020 | -1 | 0.625 |
FGR |
0.716 | -0.042 | 1 | 0.760 |
MST1R |
0.715 | -0.145 | 3 | 0.640 |
TYK2 |
0.715 | -0.137 | 1 | 0.710 |
NEK10_TYR |
0.715 | -0.023 | 1 | 0.666 |
ROS1 |
0.715 | -0.105 | 3 | 0.588 |
EPHB4 |
0.715 | -0.101 | -1 | 0.671 |
TXK |
0.714 | -0.011 | 1 | 0.710 |
TNNI3K_TYR |
0.714 | 0.003 | 1 | 0.700 |
JAK2 |
0.714 | -0.113 | 1 | 0.701 |
CSF1R |
0.713 | -0.110 | 3 | 0.606 |
TYRO3 |
0.712 | -0.170 | 3 | 0.623 |
LCK |
0.711 | -0.017 | -1 | 0.642 |
TNK2 |
0.710 | -0.064 | 3 | 0.583 |
JAK3 |
0.709 | -0.137 | 1 | 0.681 |
JAK1 |
0.709 | -0.018 | 1 | 0.664 |
CK1G3 |
0.709 | 0.053 | -3 | 0.424 |
HCK |
0.709 | -0.091 | -1 | 0.639 |
BLK |
0.708 | -0.009 | -1 | 0.652 |
TNK1 |
0.708 | -0.063 | 3 | 0.613 |
YES1 |
0.708 | -0.097 | -1 | 0.648 |
DDR1 |
0.707 | -0.196 | 4 | 0.785 |
WEE1_TYR |
0.707 | -0.062 | -1 | 0.600 |
ALPHAK3 |
0.706 | -0.104 | -1 | 0.627 |
INSRR |
0.706 | -0.143 | 3 | 0.569 |
KDR |
0.706 | -0.113 | 3 | 0.577 |
STLK3 |
0.705 | -0.110 | 1 | 0.669 |
FER |
0.705 | -0.183 | 1 | 0.723 |
ITK |
0.703 | -0.115 | -1 | 0.618 |
EPHA4 |
0.703 | -0.115 | 2 | 0.709 |
KIT |
0.703 | -0.154 | 3 | 0.613 |
FYN |
0.702 | -0.024 | -1 | 0.623 |
MET |
0.702 | -0.113 | 3 | 0.607 |
FGFR2 |
0.701 | -0.194 | 3 | 0.637 |
SRMS |
0.701 | -0.156 | 1 | 0.708 |
EPHB3 |
0.701 | -0.153 | -1 | 0.654 |
FLT1 |
0.700 | -0.102 | -1 | 0.678 |
PDGFRB |
0.700 | -0.218 | 3 | 0.622 |
EPHB1 |
0.700 | -0.182 | 1 | 0.694 |
EPHB2 |
0.699 | -0.147 | -1 | 0.648 |
MERTK |
0.698 | -0.153 | 3 | 0.600 |
FLT3 |
0.698 | -0.215 | 3 | 0.620 |
BMX |
0.697 | -0.114 | -1 | 0.549 |
AXL |
0.696 | -0.197 | 3 | 0.597 |
FGFR1 |
0.696 | -0.213 | 3 | 0.588 |
EPHA7 |
0.694 | -0.143 | 2 | 0.724 |
PDGFRA |
0.694 | -0.237 | 3 | 0.620 |
TEC |
0.693 | -0.160 | -1 | 0.553 |
CK1G2 |
0.693 | 0.031 | -3 | 0.507 |
PTK6 |
0.692 | -0.204 | -1 | 0.541 |
PTK2 |
0.692 | -0.027 | -1 | 0.654 |
LYN |
0.692 | -0.121 | 3 | 0.552 |
EPHA3 |
0.692 | -0.169 | 2 | 0.687 |
ERBB2 |
0.692 | -0.175 | 1 | 0.658 |
MATK |
0.692 | -0.124 | -1 | 0.582 |
BTK |
0.691 | -0.243 | -1 | 0.579 |
FGFR3 |
0.691 | -0.191 | 3 | 0.604 |
TEK |
0.691 | -0.249 | 3 | 0.554 |
FRK |
0.690 | -0.163 | -1 | 0.653 |
NTRK3 |
0.690 | -0.160 | -1 | 0.613 |
SYK |
0.690 | -0.020 | -1 | 0.626 |
NTRK1 |
0.690 | -0.233 | -1 | 0.657 |
SRC |
0.690 | -0.086 | -1 | 0.614 |
INSR |
0.690 | -0.187 | 3 | 0.552 |
ALK |
0.689 | -0.220 | 3 | 0.529 |
EPHA1 |
0.689 | -0.195 | 3 | 0.582 |
LTK |
0.688 | -0.212 | 3 | 0.560 |
DDR2 |
0.688 | -0.124 | 3 | 0.555 |
YANK2 |
0.687 | -0.041 | 2 | 0.369 |
NTRK2 |
0.687 | -0.246 | 3 | 0.579 |
FLT4 |
0.687 | -0.222 | 3 | 0.588 |
PTK2B |
0.687 | -0.137 | -1 | 0.586 |
EGFR |
0.687 | -0.118 | 1 | 0.564 |
FGFR4 |
0.685 | -0.123 | -1 | 0.600 |
EPHA5 |
0.683 | -0.171 | 2 | 0.694 |
EPHA8 |
0.682 | -0.163 | -1 | 0.643 |
CSK |
0.682 | -0.187 | 2 | 0.726 |
MUSK |
0.680 | -0.158 | 1 | 0.578 |
EPHA2 |
0.677 | -0.146 | -1 | 0.615 |
ZAP70 |
0.677 | -0.021 | -1 | 0.577 |
ERBB4 |
0.676 | -0.095 | 1 | 0.572 |
IGF1R |
0.673 | -0.189 | 3 | 0.498 |
FES |
0.659 | -0.190 | -1 | 0.526 |