Motif 295 (n=157)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S497 | ochoa | Golgin A8 family member Q | None |
| A1A5D9 | BICDL2 | S21 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A6NKT7 | RGPD3 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BSY2 | GOLGA8M | S497 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S496 | ochoa | Golgin subfamily A member 8R | None |
| K7EQZ3 | None | S105 | ochoa | Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) | None |
| O00429 | DNM1L | S572 | ochoa | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| O00571 | DDX3X | S102 | ochoa|psp | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O00571 | DDX3X | Y104 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O14497 | ARID1A | S367 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14715 | RGPD8 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15049 | N4BP3 | S200 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O43310 | CTIF | S245 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43524 | FOXO3 | S85 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43823 | AKAP8 | S112 | ochoa | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}. |
| O96013 | PAK4 | S142 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P02671 | FGA | S365 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P08621 | SNRNP70 | S320 | ochoa | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}. |
| P09651 | HNRNPA1 | Y341 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0C0S8 | H2AC11 | S19 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P0DJD0 | RGPD1 | S912 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S920 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMV8 | HSPA1A | Y611 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | Y611 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P12109 | COL6A1 | S388 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12109 | COL6A1 | S391 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P16104 | H2AX | S19 | ochoa | Histone H2AX (H2a/x) (Histone H2A.X) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}. |
| P17844 | DDX5 | S483 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P18065 | IGFBP2 | S154 | ochoa | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). {ECO:0000269|PubMed:16569642, ECO:0000269|PubMed:18563800, ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:26076738, ECO:0000269|PubMed:38796567}. |
| P20671 | H2AC7 | S19 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P22059 | OSBP | S79 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22681 | CBL | S20 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23246 | SFPQ | S225 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25440 | BRD2 | S591 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P25705 | ATP5F1A | S184 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P30307 | CDC25C | S61 | ochoa | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P31943 | HNRNPH1 | Y276 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P33240 | CSTF2 | S513 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P33240 | CSTF2 | S518 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P35637 | FUS | S30 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P35637 | FUS | S61 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P35658 | NUP214 | S1809 | psp | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
| P48634 | PRRC2A | S908 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S1387 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48681 | NES | S1030 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49023 | PXN | S302 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49023 | PXN | S321 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49790 | NUP153 | S937 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1140 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S1903 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P55072 | VCP | S784 | ochoa|psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P78563 | ADARB1 | S26 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| P78563 | ADARB1 | S42 | ochoa | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. |
| P98175 | RBM10 | S483 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00536 | CDK16 | S36 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00536 | CDK16 | S42 | ochoa | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q06587 | RING1 | S187 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q07820 | MCL1 | S64 | ochoa|psp | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. |
| Q08170 | SRSF4 | S78 | ochoa | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664}. |
| Q08357 | SLC20A2 | S316 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09666 | AHNAK | S5332 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5807 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | S1353 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13424 | SNTA1 | S101 | ochoa | Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}. |
| Q13425 | SNTB2 | S129 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q14004 | CDK13 | S1474 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14151 | SAFB2 | S832 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14151 | SAFB2 | S886 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14153 | FAM53B | S201 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14671 | PUM1 | S98 | ochoa | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q14676 | MDC1 | S292 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15424 | SAFB | S808 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q16777 | H2AC20 | S19 | ochoa | Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q2M1Z3 | ARHGAP31 | S382 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2M2I8 | AAK1 | S21 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q32P51 | HNRNPA1L2 | Y289 | ochoa | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}. |
| Q53GG5 | PDLIM3 | S136 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q53LP3 | SOWAHC | S230 | ochoa | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | None |
| Q5JSZ5 | PRRC2B | S194 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T4S7 | UBR4 | S2895 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5VZ18 | SHE | S69 | ochoa | SH2 domain-containing adapter protein E | None |
| Q5VZL5 | ZMYM4 | S1244 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q5XXA6 | ANO1 | S107 | ochoa | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) | Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825, ECO:0000269|PubMed:37253099}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}. |
| Q63HR2 | TNS2 | S589 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q6FI13 | H2AC18 | S19 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6P1R3 | MSANTD2 | S63 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q7L0J3 | SV2A | S127 | ochoa|psp | Synaptic vesicle glycoprotein 2A | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. {ECO:0000269|PubMed:29649119, ECO:0000305|PubMed:29649119}. |
| Q7L2J0 | MEPCE | S101 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z3J3 | RGPD4 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z460 | CLASP1 | S695 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z6Z7 | HUWE1 | S2888 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q8IUE6 | H2AC21 | S19 | ochoa | Histone H2A type 2-B (H2A-clustered histone 21) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8IWX8 | CHERP | S855 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IWZ3 | ANKHD1 | S59 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N5R6 | CCDC33 | S458 | ochoa | Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) | None |
| Q8ND25 | ZNRF1 | S62 | ochoa | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) | E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}. |
| Q8NDV7 | TNRC6A | S286 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NHG8 | ZNRF2 | S108 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAP9 | MPLKIP | S66 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TAP9 | MPLKIP | S72 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TDD1 | DDX54 | S698 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TF74 | WIPF2 | S71 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8TF74 | WIPF2 | Y74 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WXS5 | CACNG8 | S252 | ochoa | Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8) | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. {ECO:0000250|UniProtKB:Q8VHW2, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}. |
| Q93077 | H2AC6 | S19 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q969M3 | YIPF5 | S45 | ochoa | Protein YIPF5 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5) (Smooth muscle cell-associated protein 5) (SMAP-5) (YIP1 family member 5) (YPT-interacting protein 1 A) | Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi (PubMed:33164986). {ECO:0000269|PubMed:11489904, ECO:0000269|PubMed:15611160, ECO:0000269|PubMed:33164986}. |
| Q969W9 | PMEPA1 | Y219 | ochoa | Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}. |
| Q969W9 | PMEPA1 | S233 | ochoa | Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}. |
| Q96CX2 | KCTD12 | S204 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96DT7 | ZBTB10 | S647 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96F45 | ZNF503 | S285 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
| Q96KK5 | H2AC12 | S19 | ochoa | Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96RG2 | PASK | S579 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RV3 | PCNX1 | S121 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96T37 | RBM15 | S159 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99081 | TCF12 | S44 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99611 | SEPHS2 | S97 | ochoa | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}. |
| Q99666 | RGPD5 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99878 | H2AC14 | S19 | ochoa | Histone H2A type 1-J (Histone H2A/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99959 | PKP2 | S44 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BRK4 | LZTS2 | S249 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BTK6 | PAGR1 | S19 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BWG4 | SSBP4 | S350 | ochoa | Single-stranded DNA-binding protein 4 | None |
| Q9BWT7 | CARD10 | S606 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
| Q9BWW4 | SSBP3 | S355 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S762 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0W8 | SMG9 | S32 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H165 | BCL11A | S612 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H1J1 | UPF3A | S401 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H987 | SYNPO2L | S369 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9H987 | SYNPO2L | S381 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9NNW5 | WDR6 | S548 | ochoa | tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) | Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871}. |
| Q9NPF0 | CD320 | S114 | ochoa | CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320) | Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389, ECO:0000269|PubMed:20524213}. |
| Q9NRF2 | SH2B1 | S279 | ochoa | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
| Q9NWK9 | ZNHIT6 | S25 | ochoa | Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) | Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. {ECO:0000269|PubMed:17636026}. |
| Q9NY59 | SMPD3 | S289 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYF8 | BCLAF1 | Y81 | psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYV4 | CDK12 | S24 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P258 | RCC2 | S44 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9P2Y5 | UVRAG | S483 | ochoa | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UHB7 | AFF4 | S526 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHI5 | SLC7A8 | S29 | ochoa | Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) | Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11847106, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. |
| Q9UHL9 | GTF2IRD1 | S477 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UHR5 | SAP30BP | S43 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UI08 | EVL | S245 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UKX7 | NUP50 | S52 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UMD9 | COL17A1 | S45 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UMN6 | KMT2B | S936 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y6Q6 | TNFRSF11A | S513 | ochoa | Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265) | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). {ECO:0000250|UniProtKB:O35305, ECO:0000269|PubMed:9878548}. |
| P07900 | HSP90AA1 | S164 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S159 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| Q14568 | HSP90AA2P | S164 | Sugiyama | Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene) (Heat shock protein family C member 2) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| O60331 | PIP5K1C | S360 | Sugiyama | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12422219, ECO:0000269|PubMed:12847086, ECO:0000269|PubMed:17261850, ECO:0000269|PubMed:17635937, ECO:0000269|PubMed:22942276, ECO:0000305|PubMed:19889969}. |
| P52209 | PGD | S126 | Sugiyama | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| Q14694 | USP10 | S265 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| P55795 | HNRNPH2 | Y276 | Sugiyama | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| Q8N6T3 | ARFGAP1 | S277 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 2.220446e-16 | 15.654 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.998401e-15 | 14.699 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.329870e-15 | 14.364 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.327472e-15 | 14.135 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.801926e-11 | 10.108 |
| R-HSA-3214858 | RMTs methylate histone arginines | 2.913206e-10 | 9.536 |
| R-HSA-211000 | Gene Silencing by RNA | 5.728433e-10 | 9.242 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.436596e-09 | 8.613 |
| R-HSA-2262752 | Cellular responses to stress | 9.566122e-09 | 8.019 |
| R-HSA-9610379 | HCMV Late Events | 5.221557e-08 | 7.282 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.440092e-07 | 6.842 |
| R-HSA-68875 | Mitotic Prophase | 2.159738e-07 | 6.666 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.185384e-07 | 6.378 |
| R-HSA-9609690 | HCMV Early Events | 5.303392e-07 | 6.275 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.161288e-07 | 6.145 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.590887e-06 | 5.798 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.674432e-06 | 5.776 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.590887e-06 | 5.798 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.025260e-06 | 5.694 |
| R-HSA-5334118 | DNA methylation | 2.225910e-06 | 5.652 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.553203e-06 | 5.449 |
| R-HSA-5689603 | UCH proteinases | 3.475842e-06 | 5.459 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.116993e-06 | 5.385 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.463177e-06 | 5.263 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.463177e-06 | 5.263 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.767023e-06 | 5.239 |
| R-HSA-9609646 | HCMV Infection | 6.264179e-06 | 5.203 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 7.146685e-06 | 5.146 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 8.133672e-06 | 5.090 |
| R-HSA-110331 | Cleavage of the damaged purine | 8.133672e-06 | 5.090 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 8.737284e-06 | 5.059 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 8.737284e-06 | 5.059 |
| R-HSA-73927 | Depurination | 9.228325e-06 | 5.035 |
| R-HSA-9645723 | Diseases of programmed cell death | 9.804400e-06 | 5.009 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.177581e-05 | 4.929 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.177581e-05 | 4.929 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.324738e-05 | 4.878 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.324738e-05 | 4.878 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.663649e-05 | 4.779 |
| R-HSA-73928 | Depyrimidination | 1.663649e-05 | 4.779 |
| R-HSA-9710421 | Defective pyroptosis | 1.857562e-05 | 4.731 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.268279e-05 | 4.644 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.300063e-05 | 4.638 |
| R-HSA-774815 | Nucleosome assembly | 2.300063e-05 | 4.638 |
| R-HSA-3214847 | HATs acetylate histones | 2.392533e-05 | 4.621 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.551110e-05 | 4.593 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.551110e-05 | 4.593 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.890153e-05 | 4.539 |
| R-HSA-4839726 | Chromatin organization | 3.009709e-05 | 4.521 |
| R-HSA-912446 | Meiotic recombination | 4.158118e-05 | 4.381 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.950905e-05 | 4.403 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.950905e-05 | 4.403 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.950905e-05 | 4.403 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.333472e-05 | 4.363 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.464375e-05 | 4.350 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.928275e-05 | 4.307 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.928275e-05 | 4.307 |
| R-HSA-1221632 | Meiotic synapsis | 4.992692e-05 | 4.302 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.560133e-05 | 4.341 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.992692e-05 | 4.302 |
| R-HSA-977225 | Amyloid fiber formation | 4.790101e-05 | 4.320 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.457482e-05 | 4.263 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 6.305760e-05 | 4.200 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 6.305760e-05 | 4.200 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.886127e-05 | 4.230 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.353725e-05 | 4.197 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 7.097076e-05 | 4.149 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 7.097076e-05 | 4.149 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 7.674617e-05 | 4.115 |
| R-HSA-446728 | Cell junction organization | 7.937689e-05 | 4.100 |
| R-HSA-180746 | Nuclear import of Rev protein | 7.962780e-05 | 4.099 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.907555e-05 | 4.050 |
| R-HSA-8939211 | ESR-mediated signaling | 9.321848e-05 | 4.030 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.413936e-05 | 4.075 |
| R-HSA-68886 | M Phase | 9.637736e-05 | 4.016 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 9.844648e-05 | 4.007 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.988814e-05 | 4.000 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.055702e-04 | 3.976 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.055702e-04 | 3.976 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.055702e-04 | 3.976 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.105379e-04 | 3.956 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.357612e-04 | 3.867 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.226533e-04 | 3.911 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.357612e-04 | 3.867 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.424007e-04 | 3.846 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.499154e-04 | 3.824 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.499154e-04 | 3.824 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.499154e-04 | 3.824 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.651712e-04 | 3.782 |
| R-HSA-5688426 | Deubiquitination | 1.672546e-04 | 3.777 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.887415e-04 | 3.724 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.307275e-04 | 3.637 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.069525e-04 | 3.684 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.422468e-04 | 3.616 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.422468e-04 | 3.616 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.020032e-04 | 3.695 |
| R-HSA-1500931 | Cell-Cell communication | 2.387823e-04 | 3.622 |
| R-HSA-418990 | Adherens junctions interactions | 2.251324e-04 | 3.648 |
| R-HSA-8953854 | Metabolism of RNA | 2.533975e-04 | 3.596 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.600013e-04 | 3.585 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.797433e-04 | 3.553 |
| R-HSA-73864 | RNA Polymerase I Transcription | 3.167190e-04 | 3.499 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.781271e-04 | 3.422 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.021094e-04 | 3.396 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 4.021094e-04 | 3.396 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.450722e-04 | 3.352 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.717048e-04 | 3.326 |
| R-HSA-1500620 | Meiosis | 4.771966e-04 | 3.321 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.970940e-04 | 3.304 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.344085e-04 | 3.134 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.344085e-04 | 3.134 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.344085e-04 | 3.134 |
| R-HSA-72172 | mRNA Splicing | 6.357178e-04 | 3.197 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.469738e-04 | 3.127 |
| R-HSA-191859 | snRNP Assembly | 7.469738e-04 | 3.127 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.476233e-04 | 3.189 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.527191e-04 | 3.185 |
| R-HSA-1640170 | Cell Cycle | 6.638634e-04 | 3.178 |
| R-HSA-421270 | Cell-cell junction organization | 6.160543e-04 | 3.210 |
| R-HSA-73884 | Base Excision Repair | 6.598542e-04 | 3.181 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.089041e-04 | 3.092 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.510435e-04 | 3.070 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.740166e-04 | 3.011 |
| R-HSA-157579 | Telomere Maintenance | 1.030329e-03 | 2.987 |
| R-HSA-2559583 | Cellular Senescence | 1.261493e-03 | 2.899 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.574260e-03 | 2.803 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.825046e-03 | 2.739 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.844021e-03 | 2.734 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.908155e-03 | 2.719 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.222895e-03 | 2.653 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.280984e-03 | 2.642 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.355843e-03 | 2.628 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.453833e-03 | 2.610 |
| R-HSA-73886 | Chromosome Maintenance | 3.127020e-03 | 2.505 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.444952e-03 | 2.463 |
| R-HSA-1474165 | Reproduction | 4.559565e-03 | 2.341 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.797394e-03 | 2.319 |
| R-HSA-168255 | Influenza Infection | 5.050236e-03 | 2.297 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 5.051932e-03 | 2.297 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 5.194299e-03 | 2.284 |
| R-HSA-70171 | Glycolysis | 6.476966e-03 | 2.189 |
| R-HSA-73894 | DNA Repair | 6.933086e-03 | 2.159 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 7.176366e-03 | 2.144 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 8.365169e-03 | 2.078 |
| R-HSA-74160 | Gene expression (Transcription) | 8.401882e-03 | 2.076 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 8.614553e-03 | 2.065 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.113095e-02 | 1.953 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.863256e-03 | 2.052 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.098677e-02 | 1.959 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.005687e-02 | 1.998 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.012642e-02 | 1.995 |
| R-HSA-9824446 | Viral Infection Pathways | 8.756032e-03 | 2.058 |
| R-HSA-69306 | DNA Replication | 9.537849e-03 | 2.021 |
| R-HSA-70326 | Glucose metabolism | 1.258285e-02 | 1.900 |
| R-HSA-5619102 | SLC transporter disorders | 1.360041e-02 | 1.866 |
| R-HSA-72306 | tRNA processing | 1.495413e-02 | 1.825 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.541483e-02 | 1.812 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.715628e-02 | 1.766 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.715628e-02 | 1.766 |
| R-HSA-9679506 | SARS-CoV Infections | 1.828887e-02 | 1.738 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.999656e-02 | 1.699 |
| R-HSA-157118 | Signaling by NOTCH | 2.005251e-02 | 1.698 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 2.065076e-02 | 1.685 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.067683e-02 | 1.685 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.135231e-02 | 1.671 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.254027e-02 | 1.647 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.254027e-02 | 1.647 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.276090e-02 | 1.643 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.409794e-02 | 1.618 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.447036e-02 | 1.611 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.447036e-02 | 1.611 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.548973e-02 | 1.594 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.699344e-02 | 1.569 |
| R-HSA-3359485 | Defective CD320 causes MMATC | 3.081661e-02 | 1.511 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 3.081661e-02 | 1.511 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.087756e-02 | 1.389 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.087756e-02 | 1.389 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.087756e-02 | 1.389 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.087756e-02 | 1.389 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.087756e-02 | 1.389 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.087756e-02 | 1.389 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.087756e-02 | 1.389 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.087756e-02 | 1.389 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.087756e-02 | 1.389 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.087756e-02 | 1.389 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.087756e-02 | 1.389 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.852424e-02 | 1.545 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.064497e-02 | 1.514 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.064497e-02 | 1.514 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.506656e-02 | 1.455 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.369047e-02 | 1.472 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 4.087756e-02 | 1.389 |
| R-HSA-75102 | C6 deamination of adenosine | 4.087756e-02 | 1.389 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 4.087756e-02 | 1.389 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.971863e-02 | 1.401 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.971863e-02 | 1.401 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.751258e-02 | 1.560 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.506656e-02 | 1.455 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.891937e-02 | 1.410 |
| R-HSA-8848021 | Signaling by PTK6 | 3.891937e-02 | 1.410 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.122334e-02 | 1.506 |
| R-HSA-373755 | Semaphorin interactions | 3.891937e-02 | 1.410 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.688087e-02 | 1.433 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.688087e-02 | 1.433 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.244456e-02 | 1.489 |
| R-HSA-162587 | HIV Life Cycle | 3.741286e-02 | 1.427 |
| R-HSA-9839394 | TGFBR3 expression | 4.212756e-02 | 1.375 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.212756e-02 | 1.375 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.212756e-02 | 1.375 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.453599e-02 | 1.351 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.458991e-02 | 1.351 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.710433e-02 | 1.327 |
| R-HSA-195721 | Signaling by WNT | 5.035016e-02 | 1.298 |
| R-HSA-5663205 | Infectious disease | 5.327023e-02 | 1.274 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 5.765633e-02 | 1.239 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 6.068904e-02 | 1.217 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 6.068904e-02 | 1.217 |
| R-HSA-69481 | G2/M Checkpoints | 6.250788e-02 | 1.204 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 6.321112e-02 | 1.199 |
| R-HSA-6798695 | Neutrophil degranulation | 6.430788e-02 | 1.192 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.536856e-02 | 1.185 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.712793e-02 | 1.173 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.973320e-02 | 1.157 |
| R-HSA-597592 | Post-translational protein modification | 7.042956e-02 | 1.152 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 7.044170e-02 | 1.152 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 7.044170e-02 | 1.152 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 7.044170e-02 | 1.152 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.186431e-02 | 1.143 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.624405e-02 | 1.118 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.624405e-02 | 1.118 |
| R-HSA-8948216 | Collagen chain trimerization | 7.783351e-02 | 1.109 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 8.009369e-02 | 1.096 |
| R-HSA-5250992 | Toxicity of botulinum toxin type E (botE) | 8.009369e-02 | 1.096 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 8.009369e-02 | 1.096 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.009369e-02 | 1.096 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 8.395254e-02 | 1.076 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.433407e-02 | 1.074 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.084560e-01 | 0.965 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.177155e-01 | 0.929 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.359488e-01 | 0.867 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.538075e-01 | 0.813 |
| R-HSA-72187 | mRNA 3'-end processing | 1.302904e-01 | 0.885 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.698768e-01 | 0.770 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.698768e-01 | 0.770 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.084560e-01 | 0.965 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.408034e-01 | 0.851 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.538075e-01 | 0.813 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.712992e-01 | 0.766 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.408034e-01 | 0.851 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 8.964605e-02 | 1.047 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 8.964605e-02 | 1.047 |
| R-HSA-5250968 | Toxicity of botulinum toxin type A (botA) | 1.177155e-01 | 0.929 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.359488e-01 | 0.867 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.625988e-01 | 0.789 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.712992e-01 | 0.766 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.109289e-01 | 0.955 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.919502e-02 | 1.050 |
| R-HSA-192905 | vRNP Assembly | 1.359488e-01 | 0.867 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.538075e-01 | 0.813 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.625274e-01 | 0.789 |
| R-HSA-177929 | Signaling by EGFR | 1.444317e-01 | 0.840 |
| R-HSA-75072 | mRNA Editing | 1.177155e-01 | 0.929 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.449245e-01 | 0.839 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.679368e-01 | 0.775 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.177155e-01 | 0.929 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.097584e-01 | 0.960 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 9.909980e-02 | 1.004 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.084560e-01 | 0.965 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.177155e-01 | 0.929 |
| R-HSA-428540 | Activation of RAC1 | 1.449245e-01 | 0.839 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 1.625988e-01 | 0.789 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.359488e-01 | 0.867 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.538075e-01 | 0.813 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.359488e-01 | 0.867 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.359488e-01 | 0.867 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.336823e-01 | 0.874 |
| R-HSA-69275 | G2/M Transition | 1.676716e-01 | 0.776 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.099964e-01 | 0.959 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.717029e-01 | 0.765 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 1.302904e-01 | 0.885 |
| R-HSA-5689877 | Josephin domain DUBs | 1.268795e-01 | 0.897 |
| R-HSA-9607240 | FLT3 Signaling | 9.021277e-02 | 1.045 |
| R-HSA-2586552 | Signaling by Leptin | 1.268795e-01 | 0.897 |
| R-HSA-212436 | Generic Transcription Pathway | 1.444764e-01 | 0.840 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.268795e-01 | 0.897 |
| R-HSA-9635465 | Suppression of apoptosis | 1.359488e-01 | 0.867 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.712992e-01 | 0.766 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 9.021277e-02 | 1.045 |
| R-HSA-9646399 | Aggrephagy | 8.706553e-02 | 1.060 |
| R-HSA-9612973 | Autophagy | 1.101330e-01 | 0.958 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.712992e-01 | 0.766 |
| R-HSA-73893 | DNA Damage Bypass | 1.199134e-01 | 0.921 |
| R-HSA-190236 | Signaling by FGFR | 1.065737e-01 | 0.972 |
| R-HSA-422475 | Axon guidance | 1.393362e-01 | 0.856 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.661948e-01 | 0.779 |
| R-HSA-1266738 | Developmental Biology | 1.226576e-01 | 0.911 |
| R-HSA-162582 | Signal Transduction | 1.321192e-01 | 0.879 |
| R-HSA-1280218 | Adaptive Immune System | 9.239720e-02 | 1.034 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 9.984963e-02 | 1.001 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.002119e-01 | 0.999 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 1.552385e-01 | 0.809 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.169829e-01 | 0.932 |
| R-HSA-1442490 | Collagen degradation | 1.625274e-01 | 0.789 |
| R-HSA-168256 | Immune System | 9.968735e-02 | 1.001 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.625988e-01 | 0.789 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.625988e-01 | 0.789 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.091877e-01 | 0.962 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.456208e-01 | 0.837 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.712992e-01 | 0.766 |
| R-HSA-5693538 | Homology Directed Repair | 1.603877e-01 | 0.795 |
| R-HSA-162906 | HIV Infection | 1.177890e-01 | 0.929 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.461421e-01 | 0.835 |
| R-HSA-913531 | Interferon Signaling | 1.316168e-01 | 0.881 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.799098e-01 | 0.745 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.799098e-01 | 0.745 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.799098e-01 | 0.745 |
| R-HSA-8876725 | Protein methylation | 1.799098e-01 | 0.745 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.799098e-01 | 0.745 |
| R-HSA-9675108 | Nervous system development | 1.805015e-01 | 0.744 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.810025e-01 | 0.742 |
| R-HSA-68877 | Mitotic Prometaphase | 1.819271e-01 | 0.740 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.884315e-01 | 0.725 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.884315e-01 | 0.725 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 1.884315e-01 | 0.725 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.884315e-01 | 0.725 |
| R-HSA-9678110 | Attachment and Entry | 1.884315e-01 | 0.725 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 1.884796e-01 | 0.725 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.968651e-01 | 0.706 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.968651e-01 | 0.706 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.029551e-01 | 0.693 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.035550e-01 | 0.691 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.052116e-01 | 0.688 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.052116e-01 | 0.688 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.052116e-01 | 0.688 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.073455e-01 | 0.683 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.092398e-01 | 0.679 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.134719e-01 | 0.671 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.134719e-01 | 0.671 |
| R-HSA-180292 | GAB1 signalosome | 2.134719e-01 | 0.671 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.134719e-01 | 0.671 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.134719e-01 | 0.671 |
| R-HSA-380287 | Centrosome maturation | 2.149487e-01 | 0.668 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.149487e-01 | 0.668 |
| R-HSA-8852135 | Protein ubiquitination | 2.149487e-01 | 0.668 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.216468e-01 | 0.654 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.216468e-01 | 0.654 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.216468e-01 | 0.654 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.216468e-01 | 0.654 |
| R-HSA-1643685 | Disease | 2.230260e-01 | 0.652 |
| R-HSA-216083 | Integrin cell surface interactions | 2.264003e-01 | 0.645 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.268688e-01 | 0.644 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.287619e-01 | 0.641 |
| R-HSA-1632852 | Macroautophagy | 2.287619e-01 | 0.641 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.297373e-01 | 0.639 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.297373e-01 | 0.639 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.297373e-01 | 0.639 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.297373e-01 | 0.639 |
| R-HSA-1181150 | Signaling by NODAL | 2.297373e-01 | 0.639 |
| R-HSA-68882 | Mitotic Anaphase | 2.335147e-01 | 0.632 |
| R-HSA-9833482 | PKR-mediated signaling | 2.340598e-01 | 0.631 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.357407e-01 | 0.628 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.377442e-01 | 0.624 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.377442e-01 | 0.624 |
| R-HSA-210991 | Basigin interactions | 2.377442e-01 | 0.624 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.456683e-01 | 0.610 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.456683e-01 | 0.610 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.456683e-01 | 0.610 |
| R-HSA-9694614 | Attachment and Entry | 2.456683e-01 | 0.610 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.476349e-01 | 0.606 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.494208e-01 | 0.603 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.532670e-01 | 0.596 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 2.535105e-01 | 0.596 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.535105e-01 | 0.596 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.535105e-01 | 0.596 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.591958e-01 | 0.586 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.609635e-01 | 0.583 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.612717e-01 | 0.583 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.612717e-01 | 0.583 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.612717e-01 | 0.583 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.612717e-01 | 0.583 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.647906e-01 | 0.577 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.686624e-01 | 0.571 |
| R-HSA-9663891 | Selective autophagy | 2.686624e-01 | 0.571 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.689527e-01 | 0.570 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.689527e-01 | 0.570 |
| R-HSA-429947 | Deadenylation of mRNA | 2.689527e-01 | 0.570 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.689527e-01 | 0.570 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.689527e-01 | 0.570 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.763604e-01 | 0.559 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.765542e-01 | 0.558 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.765542e-01 | 0.558 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.765542e-01 | 0.558 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.840542e-01 | 0.547 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.840772e-01 | 0.547 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.840772e-01 | 0.547 |
| R-HSA-525793 | Myogenesis | 2.840772e-01 | 0.547 |
| R-HSA-8949613 | Cristae formation | 2.915225e-01 | 0.535 |
| R-HSA-1474290 | Collagen formation | 2.955803e-01 | 0.529 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.957906e-01 | 0.529 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.988907e-01 | 0.524 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.988907e-01 | 0.524 |
| R-HSA-622312 | Inflammasomes | 2.988907e-01 | 0.524 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.994170e-01 | 0.524 |
| R-HSA-1474244 | Extracellular matrix organization | 3.047124e-01 | 0.516 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.061828e-01 | 0.514 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.061828e-01 | 0.514 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 3.061828e-01 | 0.514 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.061828e-01 | 0.514 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.070802e-01 | 0.513 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.070802e-01 | 0.513 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.109061e-01 | 0.507 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.109061e-01 | 0.507 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.133995e-01 | 0.504 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.133995e-01 | 0.504 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.133995e-01 | 0.504 |
| R-HSA-182971 | EGFR downregulation | 3.205415e-01 | 0.494 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.205415e-01 | 0.494 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.261636e-01 | 0.487 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.270067e-01 | 0.485 |
| R-HSA-354192 | Integrin signaling | 3.346049e-01 | 0.475 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.346049e-01 | 0.475 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.346049e-01 | 0.475 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.346049e-01 | 0.475 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.346049e-01 | 0.475 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.346049e-01 | 0.475 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.346049e-01 | 0.475 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.346049e-01 | 0.475 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.375498e-01 | 0.472 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.415276e-01 | 0.467 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.415276e-01 | 0.467 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.483788e-01 | 0.458 |
| R-HSA-203615 | eNOS activation | 3.483788e-01 | 0.458 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.483788e-01 | 0.458 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.483788e-01 | 0.458 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.483788e-01 | 0.458 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.551591e-01 | 0.450 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.551591e-01 | 0.450 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.551591e-01 | 0.450 |
| R-HSA-8853659 | RET signaling | 3.618693e-01 | 0.441 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.618693e-01 | 0.441 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.618693e-01 | 0.441 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.618693e-01 | 0.441 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.685100e-01 | 0.434 |
| R-HSA-419037 | NCAM1 interactions | 3.685100e-01 | 0.434 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.685100e-01 | 0.434 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.750821e-01 | 0.426 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.750821e-01 | 0.426 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.750821e-01 | 0.426 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.779758e-01 | 0.423 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.815861e-01 | 0.418 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.815861e-01 | 0.418 |
| R-HSA-71336 | Pentose phosphate pathway | 3.815861e-01 | 0.418 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.824502e-01 | 0.417 |
| R-HSA-5260271 | Diseases of Immune System | 3.880229e-01 | 0.411 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.880229e-01 | 0.411 |
| R-HSA-202433 | Generation of second messenger molecules | 3.880229e-01 | 0.411 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.898141e-01 | 0.409 |
| R-HSA-392499 | Metabolism of proteins | 3.932322e-01 | 0.405 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.943930e-01 | 0.404 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.943930e-01 | 0.404 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.943930e-01 | 0.404 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.943930e-01 | 0.404 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.943930e-01 | 0.404 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.006973e-01 | 0.397 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.006973e-01 | 0.397 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.006973e-01 | 0.397 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.069363e-01 | 0.390 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.116669e-01 | 0.385 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.131107e-01 | 0.384 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.131107e-01 | 0.384 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.131107e-01 | 0.384 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.131107e-01 | 0.384 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.172652e-01 | 0.380 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.192213e-01 | 0.378 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.252686e-01 | 0.371 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.252686e-01 | 0.371 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.252686e-01 | 0.371 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.252686e-01 | 0.371 |
| R-HSA-9824439 | Bacterial Infection Pathways | 4.279359e-01 | 0.369 |
| R-HSA-194138 | Signaling by VEGF | 4.295827e-01 | 0.367 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.312532e-01 | 0.365 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.312532e-01 | 0.365 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.312532e-01 | 0.365 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.312532e-01 | 0.365 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.312532e-01 | 0.365 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.312532e-01 | 0.365 |
| R-HSA-75153 | Apoptotic execution phase | 4.312532e-01 | 0.365 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.430374e-01 | 0.354 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.488382e-01 | 0.348 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.576393e-01 | 0.339 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.576393e-01 | 0.339 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.602601e-01 | 0.337 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.658825e-01 | 0.332 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.658825e-01 | 0.332 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.658825e-01 | 0.332 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.714467e-01 | 0.327 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.714467e-01 | 0.327 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.714467e-01 | 0.327 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.781560e-01 | 0.320 |
| R-HSA-6807070 | PTEN Regulation | 4.848901e-01 | 0.314 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.848901e-01 | 0.314 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.877959e-01 | 0.312 |
| R-HSA-75893 | TNF signaling | 4.877959e-01 | 0.312 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.933342e-01 | 0.307 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.984151e-01 | 0.302 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.036423e-01 | 0.298 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.036423e-01 | 0.298 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.088154e-01 | 0.293 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.088154e-01 | 0.293 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.088154e-01 | 0.293 |
| R-HSA-449147 | Signaling by Interleukins | 5.131499e-01 | 0.290 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.145204e-01 | 0.289 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.190013e-01 | 0.285 |
| R-HSA-1268020 | Mitochondrial protein import | 5.190013e-01 | 0.285 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.190013e-01 | 0.285 |
| R-HSA-186797 | Signaling by PDGF | 5.190013e-01 | 0.285 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.235503e-01 | 0.281 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.241464e-01 | 0.281 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.289772e-01 | 0.277 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.338877e-01 | 0.273 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.343439e-01 | 0.272 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.435567e-01 | 0.265 |
| R-HSA-5218859 | Regulated Necrosis | 5.483161e-01 | 0.261 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 5.576875e-01 | 0.254 |
| R-HSA-3000178 | ECM proteoglycans | 5.623005e-01 | 0.250 |
| R-HSA-8978934 | Metabolism of cofactors | 5.623005e-01 | 0.250 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.668656e-01 | 0.247 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.668656e-01 | 0.247 |
| R-HSA-4086398 | Ca2+ pathway | 5.713834e-01 | 0.243 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.758543e-01 | 0.240 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.798815e-01 | 0.237 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.889909e-01 | 0.230 |
| R-HSA-5619084 | ABC transporter disorders | 5.932793e-01 | 0.227 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.017230e-01 | 0.221 |
| R-HSA-6806834 | Signaling by MET | 6.017230e-01 | 0.221 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.140630e-01 | 0.212 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.220777e-01 | 0.206 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.260228e-01 | 0.203 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.413979e-01 | 0.193 |
| R-HSA-5617833 | Cilium Assembly | 6.425413e-01 | 0.192 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.488482e-01 | 0.188 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.561446e-01 | 0.183 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.632903e-01 | 0.178 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.676687e-01 | 0.175 |
| R-HSA-428157 | Sphingolipid metabolism | 6.701020e-01 | 0.174 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.702883e-01 | 0.174 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.725209e-01 | 0.172 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.805152e-01 | 0.167 |
| R-HSA-5357801 | Programmed Cell Death | 6.820540e-01 | 0.166 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.838536e-01 | 0.165 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.838536e-01 | 0.165 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.871573e-01 | 0.163 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.904267e-01 | 0.161 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.907790e-01 | 0.161 |
| R-HSA-1483255 | PI Metabolism | 6.936621e-01 | 0.159 |
| R-HSA-397014 | Muscle contraction | 6.981937e-01 | 0.156 |
| R-HSA-199991 | Membrane Trafficking | 7.020757e-01 | 0.154 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.093419e-01 | 0.149 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.153881e-01 | 0.145 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.153881e-01 | 0.145 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.153881e-01 | 0.145 |
| R-HSA-202403 | TCR signaling | 7.213092e-01 | 0.142 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.213092e-01 | 0.142 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.383478e-01 | 0.132 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.464746e-01 | 0.127 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.491274e-01 | 0.125 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.517526e-01 | 0.124 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.517526e-01 | 0.124 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.569214e-01 | 0.121 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.594655e-01 | 0.119 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.594655e-01 | 0.119 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.619831e-01 | 0.118 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 7.619831e-01 | 0.118 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.644746e-01 | 0.117 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.664625e-01 | 0.116 |
| R-HSA-114608 | Platelet degranulation | 7.741838e-01 | 0.111 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.765482e-01 | 0.110 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.812036e-01 | 0.107 |
| R-HSA-5576891 | Cardiac conduction | 7.857625e-01 | 0.105 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.902270e-01 | 0.102 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.988805e-01 | 0.098 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.030732e-01 | 0.095 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.030732e-01 | 0.095 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.071790e-01 | 0.093 |
| R-HSA-9664407 | Parasite infection | 8.071790e-01 | 0.093 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.071790e-01 | 0.093 |
| R-HSA-9658195 | Leishmania infection | 8.235815e-01 | 0.084 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.235815e-01 | 0.084 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.246269e-01 | 0.084 |
| R-HSA-166520 | Signaling by NTRKs | 8.246269e-01 | 0.084 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.282858e-01 | 0.082 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.318688e-01 | 0.080 |
| R-HSA-9609507 | Protein localization | 8.336324e-01 | 0.079 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.346241e-01 | 0.079 |
| R-HSA-73887 | Death Receptor Signaling | 8.353775e-01 | 0.078 |
| R-HSA-168249 | Innate Immune System | 8.413024e-01 | 0.075 |
| R-HSA-1483257 | Phospholipid metabolism | 8.424949e-01 | 0.074 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.434801e-01 | 0.074 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.437734e-01 | 0.074 |
| R-HSA-109581 | Apoptosis | 8.486992e-01 | 0.071 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.518586e-01 | 0.070 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.694842e-01 | 0.061 |
| R-HSA-983712 | Ion channel transport | 8.874286e-01 | 0.052 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.897834e-01 | 0.051 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.029184e-01 | 0.044 |
| R-HSA-6805567 | Keratinization | 9.069412e-01 | 0.042 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.114963e-01 | 0.040 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.126667e-01 | 0.040 |
| R-HSA-8951664 | Neddylation | 9.206049e-01 | 0.036 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.270566e-01 | 0.033 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.278255e-01 | 0.033 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.329868e-01 | 0.030 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.339895e-01 | 0.030 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.491434e-01 | 0.023 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.547522e-01 | 0.020 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.566355e-01 | 0.019 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.731402e-01 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 9.734250e-01 | 0.012 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.778322e-01 | 0.010 |
| R-HSA-109582 | Hemostasis | 9.911760e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.912627e-01 | 0.004 |
| R-HSA-72766 | Translation | 9.914483e-01 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 9.938240e-01 | 0.003 |
| R-HSA-112316 | Neuronal System | 9.943761e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.968913e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.988890e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999320e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999997e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.745 | 0.148 | 1 | 0.827 |
NDR2 |
0.744 | 0.140 | -3 | 0.833 |
PIM3 |
0.743 | 0.148 | -3 | 0.822 |
CLK3 |
0.737 | 0.089 | 1 | 0.737 |
AURC |
0.737 | 0.120 | -2 | 0.553 |
PRKD1 |
0.736 | 0.143 | -3 | 0.821 |
MOS |
0.734 | 0.142 | 1 | 0.822 |
COT |
0.734 | 0.073 | 2 | 0.684 |
PRKD2 |
0.734 | 0.122 | -3 | 0.785 |
HIPK4 |
0.733 | 0.108 | 1 | 0.661 |
PIM1 |
0.732 | 0.115 | -3 | 0.779 |
RSK2 |
0.731 | 0.073 | -3 | 0.762 |
SRPK1 |
0.730 | 0.075 | -3 | 0.740 |
NEK6 |
0.730 | 0.155 | -2 | 0.768 |
NDR1 |
0.729 | 0.087 | -3 | 0.824 |
GCN2 |
0.727 | 0.059 | 2 | 0.676 |
CLK2 |
0.727 | 0.088 | -3 | 0.751 |
MST4 |
0.727 | 0.112 | 2 | 0.796 |
RSK3 |
0.726 | 0.075 | -3 | 0.757 |
MTOR |
0.726 | 0.073 | 1 | 0.634 |
LATS2 |
0.726 | 0.081 | -5 | 0.755 |
PRPK |
0.726 | 0.061 | -1 | 0.786 |
MAPKAPK2 |
0.725 | 0.080 | -3 | 0.736 |
CDK18 |
0.724 | 0.115 | 1 | 0.556 |
P90RSK |
0.724 | 0.056 | -3 | 0.765 |
CAMK2D |
0.723 | 0.075 | -3 | 0.828 |
CDKL5 |
0.723 | 0.065 | -3 | 0.770 |
NLK |
0.723 | 0.051 | 1 | 0.704 |
ATR |
0.721 | 0.042 | 1 | 0.739 |
CHAK2 |
0.721 | 0.098 | -1 | 0.734 |
MAPKAPK3 |
0.721 | 0.070 | -3 | 0.787 |
WNK1 |
0.721 | 0.082 | -2 | 0.780 |
SKMLCK |
0.720 | 0.068 | -2 | 0.740 |
PKACB |
0.720 | 0.076 | -2 | 0.567 |
CDK7 |
0.719 | 0.062 | 1 | 0.610 |
PDHK4 |
0.719 | -0.043 | 1 | 0.700 |
PKCA |
0.719 | 0.119 | 2 | 0.636 |
DSTYK |
0.719 | 0.009 | 2 | 0.741 |
ERK5 |
0.718 | 0.036 | 1 | 0.692 |
KIS |
0.718 | 0.034 | 1 | 0.606 |
IKKB |
0.718 | -0.024 | -2 | 0.595 |
TGFBR2 |
0.718 | 0.031 | -2 | 0.671 |
CDKL1 |
0.718 | 0.038 | -3 | 0.775 |
CAMK2B |
0.718 | 0.028 | 2 | 0.645 |
P70S6KB |
0.718 | 0.056 | -3 | 0.784 |
CAMK1B |
0.718 | 0.006 | -3 | 0.833 |
PKCD |
0.717 | 0.086 | 2 | 0.661 |
SRPK2 |
0.717 | 0.047 | -3 | 0.665 |
RAF1 |
0.717 | -0.047 | 1 | 0.702 |
ULK2 |
0.717 | 0.038 | 2 | 0.624 |
NUAK2 |
0.717 | 0.011 | -3 | 0.837 |
PRKX |
0.716 | 0.072 | -3 | 0.706 |
DAPK2 |
0.716 | 0.050 | -3 | 0.841 |
RSK4 |
0.716 | 0.067 | -3 | 0.739 |
PKACG |
0.716 | 0.043 | -2 | 0.623 |
BMPR2 |
0.716 | 0.023 | -2 | 0.747 |
GRK1 |
0.716 | 0.024 | -2 | 0.614 |
PDHK1 |
0.715 | 0.006 | 1 | 0.676 |
HIPK2 |
0.715 | 0.080 | 1 | 0.537 |
MARK4 |
0.715 | 0.003 | 4 | 0.279 |
BMPR1B |
0.715 | 0.080 | 1 | 0.787 |
NEK9 |
0.715 | 0.114 | 2 | 0.713 |
AURB |
0.715 | 0.064 | -2 | 0.555 |
PKCB |
0.715 | 0.088 | 2 | 0.631 |
ICK |
0.715 | 0.065 | -3 | 0.815 |
PKN3 |
0.715 | 0.025 | -3 | 0.814 |
NEK7 |
0.714 | 0.040 | -3 | 0.819 |
NIK |
0.714 | 0.043 | -3 | 0.851 |
MNK2 |
0.714 | 0.076 | -2 | 0.687 |
CDK5 |
0.714 | 0.084 | 1 | 0.634 |
CAMK2A |
0.714 | 0.008 | 2 | 0.673 |
PKCG |
0.714 | 0.076 | 2 | 0.628 |
CAMK2G |
0.714 | -0.063 | 2 | 0.663 |
CDK13 |
0.714 | 0.058 | 1 | 0.580 |
CAMLCK |
0.713 | 0.023 | -2 | 0.714 |
PKN2 |
0.713 | 0.037 | -3 | 0.828 |
PIM2 |
0.713 | 0.089 | -3 | 0.742 |
DYRK2 |
0.712 | 0.054 | 1 | 0.601 |
CDK19 |
0.712 | 0.042 | 1 | 0.556 |
TBK1 |
0.712 | -0.058 | 1 | 0.569 |
CLK4 |
0.712 | 0.045 | -3 | 0.763 |
GRK5 |
0.712 | -0.048 | -3 | 0.798 |
MLK2 |
0.711 | 0.105 | 2 | 0.693 |
BCKDK |
0.711 | -0.014 | -1 | 0.690 |
HIPK1 |
0.711 | 0.080 | 1 | 0.619 |
AMPKA1 |
0.711 | 0.012 | -3 | 0.848 |
CDK12 |
0.711 | 0.066 | 1 | 0.546 |
CLK1 |
0.711 | 0.051 | -3 | 0.747 |
RIPK3 |
0.711 | -0.012 | 3 | 0.531 |
SRPK3 |
0.710 | 0.027 | -3 | 0.703 |
CDK8 |
0.710 | 0.032 | 1 | 0.583 |
IKKE |
0.710 | -0.073 | 1 | 0.561 |
PKR |
0.710 | 0.152 | 1 | 0.700 |
TGFBR1 |
0.709 | 0.051 | -2 | 0.659 |
IKKA |
0.709 | 0.021 | -2 | 0.587 |
PAK1 |
0.709 | 0.038 | -2 | 0.642 |
PKCZ |
0.708 | 0.076 | 2 | 0.665 |
SMG1 |
0.708 | 0.055 | 1 | 0.699 |
PRKD3 |
0.708 | 0.045 | -3 | 0.751 |
MNK1 |
0.708 | 0.050 | -2 | 0.682 |
MASTL |
0.708 | -0.035 | -2 | 0.711 |
FAM20C |
0.707 | 0.005 | 2 | 0.480 |
AMPKA2 |
0.707 | 0.010 | -3 | 0.821 |
CDK9 |
0.707 | 0.039 | 1 | 0.580 |
PHKG1 |
0.707 | 0.033 | -3 | 0.824 |
LATS1 |
0.706 | 0.056 | -3 | 0.838 |
TSSK1 |
0.706 | 0.018 | -3 | 0.864 |
PKG2 |
0.706 | 0.041 | -2 | 0.561 |
PAK6 |
0.706 | 0.046 | -2 | 0.580 |
MLK1 |
0.706 | -0.034 | 2 | 0.686 |
P38A |
0.705 | 0.053 | 1 | 0.612 |
AURA |
0.705 | 0.030 | -2 | 0.537 |
QSK |
0.705 | -0.005 | 4 | 0.266 |
CDK1 |
0.705 | 0.031 | 1 | 0.573 |
CDK14 |
0.705 | 0.074 | 1 | 0.590 |
MSK2 |
0.705 | 0.003 | -3 | 0.736 |
SGK3 |
0.705 | 0.070 | -3 | 0.772 |
MSK1 |
0.704 | 0.015 | -3 | 0.742 |
NEK2 |
0.704 | 0.065 | 2 | 0.714 |
GSK3A |
0.704 | -0.014 | 4 | 0.144 |
CDK17 |
0.704 | 0.063 | 1 | 0.506 |
AKT2 |
0.704 | 0.058 | -3 | 0.695 |
DNAPK |
0.704 | 0.029 | 1 | 0.610 |
IRE1 |
0.704 | -0.002 | 1 | 0.649 |
NIM1 |
0.703 | -0.015 | 3 | 0.536 |
HUNK |
0.703 | -0.098 | 2 | 0.624 |
CDK3 |
0.703 | 0.045 | 1 | 0.532 |
GSK3B |
0.703 | -0.037 | 4 | 0.140 |
CDK10 |
0.703 | 0.057 | 1 | 0.584 |
JNK2 |
0.703 | 0.053 | 1 | 0.544 |
GRK6 |
0.703 | -0.084 | 1 | 0.741 |
ATM |
0.703 | -0.014 | 1 | 0.709 |
P38G |
0.702 | 0.054 | 1 | 0.492 |
PAK3 |
0.702 | 0.004 | -2 | 0.638 |
MLK3 |
0.702 | 0.010 | 2 | 0.645 |
ALK4 |
0.702 | -0.012 | -2 | 0.686 |
ALK2 |
0.701 | 0.023 | -2 | 0.668 |
WNK3 |
0.700 | -0.093 | 1 | 0.652 |
RIPK1 |
0.700 | -0.022 | 1 | 0.653 |
MPSK1 |
0.700 | 0.167 | 1 | 0.736 |
VRK2 |
0.700 | 0.145 | 1 | 0.726 |
TLK2 |
0.700 | 0.072 | 1 | 0.648 |
MELK |
0.700 | 0.013 | -3 | 0.806 |
PRP4 |
0.700 | 0.092 | -3 | 0.770 |
DCAMKL1 |
0.700 | 0.070 | -3 | 0.801 |
DYRK4 |
0.699 | 0.030 | 1 | 0.552 |
ACVR2B |
0.699 | 0.019 | -2 | 0.654 |
PKCH |
0.699 | 0.014 | 2 | 0.601 |
TTBK2 |
0.699 | -0.052 | 2 | 0.569 |
MARK3 |
0.699 | -0.032 | 4 | 0.234 |
ERK1 |
0.698 | 0.031 | 1 | 0.543 |
HIPK3 |
0.698 | 0.041 | 1 | 0.591 |
PKACA |
0.698 | 0.038 | -2 | 0.521 |
GRK7 |
0.698 | -0.005 | 1 | 0.675 |
P38B |
0.698 | 0.037 | 1 | 0.550 |
CDK16 |
0.698 | 0.049 | 1 | 0.526 |
ANKRD3 |
0.698 | -0.044 | 1 | 0.705 |
CHAK1 |
0.697 | -0.015 | 2 | 0.680 |
PERK |
0.697 | 0.065 | -2 | 0.705 |
DYRK1A |
0.697 | 0.034 | 1 | 0.623 |
SIK |
0.697 | -0.019 | -3 | 0.760 |
MAK |
0.697 | 0.105 | -2 | 0.600 |
TSSK2 |
0.697 | -0.053 | -5 | 0.816 |
BMPR1A |
0.697 | 0.048 | 1 | 0.780 |
ACVR2A |
0.697 | -0.001 | -2 | 0.652 |
MST3 |
0.697 | 0.086 | 2 | 0.748 |
NUAK1 |
0.697 | -0.022 | -3 | 0.791 |
NEK5 |
0.697 | 0.139 | 1 | 0.686 |
BRSK1 |
0.696 | -0.039 | -3 | 0.797 |
QIK |
0.696 | -0.059 | -3 | 0.823 |
ULK1 |
0.696 | -0.091 | -3 | 0.779 |
CHK1 |
0.696 | 0.016 | -3 | 0.816 |
MYLK4 |
0.696 | -0.010 | -2 | 0.635 |
DLK |
0.696 | -0.114 | 1 | 0.676 |
DRAK1 |
0.696 | -0.014 | 1 | 0.680 |
DYRK3 |
0.695 | 0.046 | 1 | 0.611 |
WNK4 |
0.695 | 0.076 | -2 | 0.804 |
BRSK2 |
0.695 | -0.040 | -3 | 0.819 |
CAMK4 |
0.695 | -0.062 | -3 | 0.813 |
P38D |
0.695 | 0.053 | 1 | 0.533 |
GRK4 |
0.695 | -0.109 | -2 | 0.681 |
JNK3 |
0.695 | 0.021 | 1 | 0.571 |
YSK4 |
0.695 | 0.001 | 1 | 0.613 |
MEK1 |
0.695 | -0.043 | 2 | 0.674 |
MARK2 |
0.693 | -0.058 | 4 | 0.223 |
PKCT |
0.693 | 0.038 | 2 | 0.608 |
PAK2 |
0.692 | -0.023 | -2 | 0.632 |
DYRK1B |
0.692 | 0.026 | 1 | 0.580 |
MOK |
0.692 | 0.096 | 1 | 0.634 |
ERK7 |
0.692 | 0.069 | 2 | 0.559 |
MAPKAPK5 |
0.691 | -0.035 | -3 | 0.717 |
PBK |
0.691 | 0.204 | 1 | 0.792 |
PKCE |
0.691 | 0.037 | 2 | 0.628 |
LKB1 |
0.690 | 0.133 | -3 | 0.838 |
ROCK2 |
0.690 | 0.116 | -3 | 0.793 |
DAPK3 |
0.690 | 0.043 | -3 | 0.798 |
P70S6K |
0.690 | 0.023 | -3 | 0.701 |
AKT1 |
0.690 | 0.039 | -3 | 0.721 |
MEKK1 |
0.690 | 0.033 | 1 | 0.651 |
PLK1 |
0.690 | -0.087 | -2 | 0.689 |
PKCI |
0.690 | 0.033 | 2 | 0.648 |
CK2A2 |
0.689 | 0.002 | 1 | 0.737 |
TAO3 |
0.689 | 0.075 | 1 | 0.636 |
IRE2 |
0.689 | -0.061 | 2 | 0.585 |
GAK |
0.689 | 0.144 | 1 | 0.829 |
CDK2 |
0.689 | -0.023 | 1 | 0.633 |
MLK4 |
0.688 | -0.037 | 2 | 0.603 |
PASK |
0.687 | -0.008 | -3 | 0.834 |
CK1E |
0.686 | 0.003 | -3 | 0.533 |
HRI |
0.686 | -0.048 | -2 | 0.716 |
IRAK4 |
0.685 | -0.004 | 1 | 0.645 |
BUB1 |
0.685 | 0.091 | -5 | 0.763 |
PHKG2 |
0.685 | -0.019 | -3 | 0.794 |
MARK1 |
0.685 | -0.084 | 4 | 0.247 |
PAK5 |
0.685 | 0.021 | -2 | 0.529 |
CAMK1G |
0.684 | -0.043 | -3 | 0.752 |
DAPK1 |
0.684 | 0.023 | -3 | 0.777 |
PLK4 |
0.684 | -0.012 | 2 | 0.442 |
SGK1 |
0.684 | 0.050 | -3 | 0.620 |
MRCKB |
0.683 | 0.057 | -3 | 0.740 |
PINK1 |
0.683 | -0.058 | 1 | 0.725 |
AKT3 |
0.682 | 0.040 | -3 | 0.642 |
MEK5 |
0.682 | -0.078 | 2 | 0.671 |
CK2A1 |
0.682 | -0.014 | 1 | 0.712 |
SNRK |
0.682 | -0.116 | 2 | 0.507 |
PAK4 |
0.682 | 0.005 | -2 | 0.541 |
GRK2 |
0.682 | -0.063 | -2 | 0.566 |
NEK4 |
0.682 | 0.053 | 1 | 0.626 |
CAMK1D |
0.681 | -0.005 | -3 | 0.711 |
CDK6 |
0.681 | 0.028 | 1 | 0.574 |
ERK2 |
0.681 | -0.029 | 1 | 0.565 |
SMMLCK |
0.681 | -0.029 | -3 | 0.796 |
DCAMKL2 |
0.681 | -0.017 | -3 | 0.813 |
PLK3 |
0.681 | -0.120 | 2 | 0.590 |
CK1G1 |
0.681 | -0.001 | -3 | 0.521 |
CDK4 |
0.681 | 0.025 | 1 | 0.540 |
TNIK |
0.680 | 0.072 | 3 | 0.617 |
GCK |
0.680 | 0.053 | 1 | 0.648 |
PDHK3_TYR |
0.680 | 0.168 | 4 | 0.342 |
ZAK |
0.680 | -0.043 | 1 | 0.606 |
HPK1 |
0.679 | 0.055 | 1 | 0.626 |
TAO2 |
0.679 | 0.006 | 2 | 0.719 |
TLK1 |
0.678 | -0.077 | -2 | 0.680 |
VRK1 |
0.678 | 0.171 | 2 | 0.639 |
LOK |
0.678 | 0.049 | -2 | 0.646 |
KHS2 |
0.678 | 0.081 | 1 | 0.625 |
NEK1 |
0.678 | 0.094 | 1 | 0.641 |
CK1D |
0.678 | 0.001 | -3 | 0.487 |
CAMKK1 |
0.678 | -0.018 | -2 | 0.628 |
MEKK2 |
0.678 | -0.043 | 2 | 0.654 |
KHS1 |
0.677 | 0.087 | 1 | 0.606 |
JNK1 |
0.677 | -0.001 | 1 | 0.546 |
BRAF |
0.677 | -0.075 | -4 | 0.732 |
CAMKK2 |
0.677 | -0.006 | -2 | 0.629 |
MEKK6 |
0.677 | 0.036 | 1 | 0.628 |
NEK3 |
0.676 | 0.143 | 1 | 0.578 |
PKMYT1_TYR |
0.676 | 0.192 | 3 | 0.626 |
LIMK2_TYR |
0.676 | 0.205 | -3 | 0.862 |
MAP2K4_TYR |
0.676 | 0.159 | -1 | 0.796 |
MRCKA |
0.676 | 0.028 | -3 | 0.757 |
SSTK |
0.675 | -0.065 | 4 | 0.265 |
NEK11 |
0.675 | -0.061 | 1 | 0.625 |
PDK1 |
0.674 | 0.004 | 1 | 0.626 |
HGK |
0.674 | 0.032 | 3 | 0.605 |
PKN1 |
0.674 | -0.002 | -3 | 0.729 |
MINK |
0.674 | 0.057 | 1 | 0.619 |
BIKE |
0.674 | 0.161 | 1 | 0.800 |
DMPK1 |
0.673 | 0.058 | -3 | 0.762 |
CK1A2 |
0.673 | -0.014 | -3 | 0.489 |
GRK3 |
0.673 | -0.049 | -2 | 0.527 |
SBK |
0.673 | 0.026 | -3 | 0.587 |
NEK8 |
0.672 | -0.056 | 2 | 0.683 |
LRRK2 |
0.672 | -0.000 | 2 | 0.719 |
CHK2 |
0.672 | 0.006 | -3 | 0.651 |
MAP3K15 |
0.672 | 0.015 | 1 | 0.589 |
EEF2K |
0.672 | -0.011 | 3 | 0.565 |
AAK1 |
0.671 | 0.195 | 1 | 0.741 |
YSK1 |
0.671 | 0.062 | 2 | 0.720 |
MEKK3 |
0.670 | -0.142 | 1 | 0.639 |
TESK1_TYR |
0.670 | 0.068 | 3 | 0.638 |
PDHK4_TYR |
0.670 | 0.049 | 2 | 0.724 |
ROCK1 |
0.670 | 0.056 | -3 | 0.757 |
CRIK |
0.670 | 0.056 | -3 | 0.713 |
MAP2K6_TYR |
0.668 | 0.026 | -1 | 0.776 |
TXK |
0.667 | 0.119 | 1 | 0.781 |
MYO3B |
0.667 | 0.094 | 2 | 0.733 |
MST2 |
0.667 | -0.005 | 1 | 0.658 |
TTBK1 |
0.666 | -0.119 | 2 | 0.485 |
TAK1 |
0.665 | -0.012 | 1 | 0.674 |
CAMK1A |
0.665 | -0.012 | -3 | 0.667 |
PKG1 |
0.665 | -0.001 | -2 | 0.489 |
STK33 |
0.664 | -0.068 | 2 | 0.486 |
FGR |
0.664 | 0.108 | 1 | 0.755 |
MAP2K7_TYR |
0.664 | -0.024 | 2 | 0.699 |
MEK2 |
0.664 | -0.041 | 2 | 0.650 |
BLK |
0.664 | 0.132 | -1 | 0.781 |
ABL2 |
0.664 | 0.091 | -1 | 0.760 |
TNK2 |
0.664 | 0.116 | 3 | 0.518 |
ABL1 |
0.663 | 0.110 | -1 | 0.764 |
SLK |
0.663 | -0.036 | -2 | 0.589 |
HASPIN |
0.663 | 0.042 | -1 | 0.704 |
LCK |
0.662 | 0.122 | -1 | 0.770 |
IRAK1 |
0.662 | -0.165 | -1 | 0.684 |
PDHK1_TYR |
0.662 | 0.012 | -1 | 0.785 |
OSR1 |
0.660 | 0.057 | 2 | 0.686 |
EPHB4 |
0.660 | 0.037 | -1 | 0.740 |
LIMK1_TYR |
0.660 | 0.002 | 2 | 0.703 |
BMPR2_TYR |
0.659 | -0.027 | -1 | 0.766 |
PLK2 |
0.658 | -0.092 | -3 | 0.708 |
YES1 |
0.658 | 0.034 | -1 | 0.804 |
HCK |
0.656 | 0.071 | -1 | 0.775 |
EPHA6 |
0.656 | -0.011 | -1 | 0.757 |
TTK |
0.656 | 0.002 | -2 | 0.707 |
YANK3 |
0.656 | -0.044 | 2 | 0.317 |
MST1 |
0.656 | -0.080 | 1 | 0.622 |
PINK1_TYR |
0.656 | -0.123 | 1 | 0.699 |
RET |
0.655 | -0.013 | 1 | 0.627 |
MST1R |
0.655 | -0.001 | 3 | 0.582 |
TYRO3 |
0.655 | 0.017 | 3 | 0.550 |
TAO1 |
0.653 | -0.003 | 1 | 0.544 |
ROS1 |
0.653 | -0.005 | 3 | 0.535 |
ITK |
0.653 | 0.046 | -1 | 0.739 |
CK1A |
0.652 | -0.003 | -3 | 0.403 |
SRMS |
0.651 | 0.006 | 1 | 0.764 |
TYK2 |
0.651 | -0.039 | 1 | 0.629 |
FER |
0.651 | -0.042 | 1 | 0.786 |
EPHB3 |
0.651 | 0.033 | -1 | 0.728 |
MERTK |
0.650 | 0.052 | 3 | 0.546 |
NEK10_TYR |
0.650 | 0.019 | 1 | 0.511 |
TNNI3K_TYR |
0.649 | 0.041 | 1 | 0.627 |
TNK1 |
0.649 | 0.019 | 3 | 0.554 |
JAK2 |
0.649 | -0.038 | 1 | 0.616 |
JAK1 |
0.648 | 0.030 | 1 | 0.561 |
BMX |
0.648 | 0.018 | -1 | 0.699 |
FYN |
0.648 | 0.046 | -1 | 0.759 |
MYO3A |
0.647 | -0.007 | 1 | 0.610 |
EPHA4 |
0.646 | -0.041 | 2 | 0.606 |
AXL |
0.646 | 0.020 | 3 | 0.535 |
EPHB2 |
0.646 | 0.002 | -1 | 0.719 |
RIPK2 |
0.646 | -0.182 | 1 | 0.568 |
CSF1R |
0.645 | -0.055 | 3 | 0.543 |
PTK6 |
0.645 | 0.005 | -1 | 0.691 |
ASK1 |
0.644 | -0.064 | 1 | 0.582 |
EPHB1 |
0.644 | -0.046 | 1 | 0.736 |
EPHA1 |
0.643 | 0.010 | 3 | 0.528 |
PTK2B |
0.642 | -0.003 | -1 | 0.758 |
TEC |
0.642 | -0.025 | -1 | 0.735 |
DDR1 |
0.642 | -0.171 | 4 | 0.268 |
EPHA7 |
0.641 | -0.017 | 2 | 0.600 |
WEE1_TYR |
0.640 | -0.029 | -1 | 0.688 |
JAK3 |
0.639 | -0.089 | 1 | 0.614 |
LYN |
0.639 | -0.010 | 3 | 0.498 |
SRC |
0.638 | 0.026 | -1 | 0.776 |
BTK |
0.638 | -0.065 | -1 | 0.734 |
LTK |
0.638 | -0.058 | 3 | 0.514 |
INSRR |
0.637 | -0.119 | 3 | 0.499 |
MET |
0.636 | -0.071 | 3 | 0.546 |
KDR |
0.636 | -0.084 | 3 | 0.510 |
ALPHAK3 |
0.636 | -0.094 | -1 | 0.684 |
TEK |
0.635 | -0.096 | 3 | 0.479 |
ALK |
0.635 | -0.095 | 3 | 0.475 |
EPHA3 |
0.634 | -0.076 | 2 | 0.577 |
PDGFRB |
0.634 | -0.115 | 3 | 0.546 |
KIT |
0.634 | -0.105 | 3 | 0.535 |
FRK |
0.633 | -0.049 | -1 | 0.788 |
FGFR2 |
0.633 | -0.145 | 3 | 0.548 |
EPHA5 |
0.631 | -0.047 | 2 | 0.572 |
NTRK1 |
0.631 | -0.098 | -1 | 0.718 |
STLK3 |
0.630 | -0.070 | 1 | 0.573 |
FGFR1 |
0.630 | -0.106 | 3 | 0.522 |
EPHA8 |
0.629 | -0.038 | -1 | 0.718 |
FLT3 |
0.629 | -0.153 | 3 | 0.538 |
PDGFRA |
0.628 | -0.135 | 3 | 0.547 |
NTRK3 |
0.627 | -0.059 | -1 | 0.684 |
MATK |
0.627 | -0.069 | -1 | 0.684 |
DDR2 |
0.625 | -0.121 | 3 | 0.482 |
PTK2 |
0.624 | -0.025 | -1 | 0.660 |
ERBB2 |
0.624 | -0.127 | 1 | 0.609 |
INSR |
0.623 | -0.126 | 3 | 0.502 |
FLT1 |
0.622 | -0.138 | -1 | 0.697 |
NTRK2 |
0.621 | -0.134 | 3 | 0.509 |
CSK |
0.620 | -0.095 | 2 | 0.599 |
EPHA2 |
0.620 | -0.056 | -1 | 0.673 |
YANK2 |
0.619 | -0.069 | 2 | 0.328 |
SYK |
0.619 | -0.037 | -1 | 0.662 |
FGFR3 |
0.618 | -0.170 | 3 | 0.517 |
EGFR |
0.617 | -0.078 | 1 | 0.527 |
FLT4 |
0.617 | -0.165 | 3 | 0.526 |
CK1G3 |
0.616 | -0.044 | -3 | 0.360 |
MUSK |
0.614 | -0.083 | 1 | 0.523 |
FGFR4 |
0.612 | -0.097 | -1 | 0.686 |
FES |
0.610 | -0.064 | -1 | 0.682 |
ERBB4 |
0.609 | -0.079 | 1 | 0.586 |
IGF1R |
0.607 | -0.140 | 3 | 0.449 |
ZAP70 |
0.603 | -0.031 | -1 | 0.607 |
CK1G2 |
0.602 | -0.062 | -3 | 0.446 |