Motif 291 (n=131)

Position-wise Probabilities
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uniprot genes site source protein function
A0A087X0R7 SENP3-EIF4A1 S142 ochoa SENP3-EIF4A1 readthrough (NMD candidate) None
A0FGR8 ESYT2 S699 ochoa Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.
A4D1S0 KLRG2 S212 ochoa Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) None
A6NI72 NCF1B S346 ochoa Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B) May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.
A8MPP1 DDX11L8 T104 ochoa Putative ATP-dependent DNA helicase DDX11-like protein 8 (EC 5.6.2.-) (DEAD/H box protein 11-like 8) Putative DNA helicase. {ECO:0000305}.
A8MVU1 NCF1C S321 ochoa Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C) May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.
B0YJ81 HACD1 S22 ochoa Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A) [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.; FUNCTION: [Isoform 2]: In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum. {ECO:0000269|PubMed:22067203}.
H7C1W4 None S55 ochoa Uncharacterized protein None
O14640 DVL1 S115 ochoa Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14640 DVL1 S602 ochoa Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14908 GIPC1 S232 ochoa PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) May be involved in G protein-linked signaling.
O43295 SRGAP3 S874 ochoa SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
O75145 PPFIA3 S1164 ochoa Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.
O75150 RNF40 S528 ochoa E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
O94916 NFAT5 S649 ochoa Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
O94992 HEXIM1 S69 ochoa Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.
O95071 UBR5 S174 ochoa|psp E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95210 STBD1 S55 ochoa Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}.
O95359 TACC2 S758 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95475 SIX6 S221 ochoa Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) May be involved in eye development.
P02545 LMNA S507 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P04083 ANXA1 S37 ochoa Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.
P04920 SLC4A2 S461 ochoa Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2) Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}.
P05060 CHGB S130 ochoa Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
P0DPH7 TUBA3C S48 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D S48 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P14598 NCF1 S345 ochoa|psp Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}.
P14618 PKM S205 ochoa Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}.
P15036 ETS2 S220 psp Protein C-ets-2 Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}.
P19419 ELK1 S303 ochoa ETS domain-containing protein Elk-1 Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.
P23511 NFYA S320 psp Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}.
P25440 BRD2 S301 ochoa Bromodomain-containing protein 2 (O27.1.1) Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}.
P31323 PRKAR2B S71 ochoa cAMP-dependent protein kinase type II-beta regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P31785 IL2RG S349 ochoa Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). {ECO:0000269|PubMed:15123770}.
P33240 CSTF2 S518 ochoa Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}.
P41235 HNF4A S443 psp Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}.
P46379 BAG6 S113 ochoa Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.
P49023 PXN S320 ochoa Paxillin Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
P51617 IRAK1 S556 ochoa Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P51810 GPR143 S343 ochoa G-protein coupled receptor 143 (Ocular albinism type 1 protein) Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}.
P62937 PPIA S51 ochoa Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}.
P68363 TUBA1B S48 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A S48 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78344 EIF4G2 S22 ochoa Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.
Q02078 MEF2A S210 ochoa Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}.
Q02790 FKBP4 S118 ochoa Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Q03252 LMNB2 S541 ochoa Lamin-B2 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}.
Q12948 FOXC1 S235 ochoa Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.
Q12979 ABR S72 ochoa Active breakpoint cluster region-related protein Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.
Q13136 PPFIA1 S530 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q14012 CAMK1 S333 ochoa Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}.
Q15149 PLEC S125 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15942 ZYX S308 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16799 RTN1 S65 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q2M296 MTHFSD S296 ochoa Methenyltetrahydrofolate synthase domain-containing protein None
Q2TAZ0 ATG2A S1653 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q4ADV7 RIC1 S990 ochoa Guanine nucleotide exchange factor subunit RIC1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1) The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). {ECO:0000269|PubMed:16112082, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:31932796}.
Q4KMP7 TBC1D10B S678 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q4L180 FILIP1L S1013 ochoa Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}.
Q53TN4 CYBRD1 S248 ochoa Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). {ECO:0000250|UniProtKB:Q925G2, ECO:0000269|PubMed:17068337, ECO:0000269|PubMed:30272000, ECO:0000305|PubMed:16510471}.
Q5JSZ5 PRRC2B S1453 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5JTC6 AMER1 S240 ochoa APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Q5SXM8 DNLZ S157 ochoa DNL-type zinc finger protein (Hsp70-escort protein 1) (HEP1) (mtHsp70-escort protein) May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. {ECO:0000269|PubMed:23462535}.
Q5T5Y3 CAMSAP1 S416 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5VWQ8 DAB2IP S763 ochoa Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}.
Q68EM7 ARHGAP17 S575 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q69YH5 CDCA2 S98 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6P1L5 FAM117B S136 ochoa Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) None
Q6PEY2 TUBA3E S48 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PJ69 TRIM65 S367 psp E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252). This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402). Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:31160576, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:33373584, ECO:0000269|PubMed:34512673}.
Q6WKZ4 RAB11FIP1 S1171 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZTU2 EP400P1 S304 ochoa Putative EP400-like protein (EP400 pseudogene 1) None
Q71U36 TUBA1A S48 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7L804 RAB11FIP2 S382 ochoa Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}.
Q7Z2Z1 TICRR S1413 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z406 MYH14 S42 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q7Z7A3 CTU1 S200 ochoa Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1) Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}.
Q86UD0 SAPCD2 S284 ochoa Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3) Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}.
Q8IVT2 MISP S213 ochoa Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IVW6 ARID3B S61 ochoa AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}.
Q8N0Y2 ZNF444 S235 ochoa Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.
Q8N1I0 DOCK4 S1787 ochoa Dedicator of cytokinesis protein 4 Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}.
Q8N2Y8 RUSC2 S559 ochoa AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.
Q8NC74 RBBP8NL S190 ochoa RBBP8 N-terminal-like protein None
Q8NFZ4 NLGN2 S720 ochoa Neuroligin-2 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}.
Q8TAD8 SNIP1 S200 ochoa Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
Q8TDC3 BRSK1 S413 ochoa Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.
Q8WTS6 SETD7 S340 ochoa Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:15525938, PubMed:16415881, PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:15525938, PubMed:16415881, PubMed:17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). {ECO:0000250|UniProtKB:Q8VHL1, ECO:0000269|PubMed:11779497, ECO:0000269|PubMed:11850410, ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:16415881, ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:35210392}.
Q92522 H1-10 S154 ochoa Histone H1.10 (Histone H1x) Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Q92771 DDX12P T123 ochoa Putative ATP-dependent DNA helicase DDX12 (EC 5.6.2.-) (CHL1-related protein 2) (hCHLR2) (DEAD/H box protein 12) DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity). {ECO:0000250}.
Q92994 BRF1 S392 ochoa Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
Q92994 BRF1 S398 ochoa Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
Q92997 DVL3 S112 ochoa Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q93075 TATDN2 S112 ochoa 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}.
Q969R8 ITFG2 S220 ochoa KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.
Q96FC9 DDX11 T104 ochoa ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2) DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:10648783, PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Also shows ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Also cooperates with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Also plays a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:18499658, PubMed:22102414, PubMed:9013641). {ECO:0000250|UniProtKB:Q6AXC6, ECO:0000269|PubMed:10648783, ECO:0000269|PubMed:17105772, ECO:0000269|PubMed:18499658, ECO:0000269|PubMed:20124417, ECO:0000269|PubMed:21854770, ECO:0000269|PubMed:22102414, ECO:0000269|PubMed:23116066, ECO:0000269|PubMed:23797032, ECO:0000269|PubMed:26089203, ECO:0000269|PubMed:26503245, ECO:0000269|PubMed:27477908}.; FUNCTION: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated. {ECO:0000269|PubMed:17189189}.
Q96G42 KLHDC7B S164 ochoa Kelch domain-containing protein 7B None
Q96HB5 CCDC120 S376 ochoa Coiled-coil domain-containing protein 120 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}.
Q96IF1 AJUBA S155 ochoa LIM domain-containing protein ajuba Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.
Q96L73 NSD1 S224 ochoa Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.
Q96L91 EP400 S315 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96PE2 ARHGEF17 S326 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96RT1 ERBIN S1060 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96S21 RAB40C S252 ochoa Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}.
Q9BQE3 TUBA1C S48 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BSI4 TINF2 S330 ochoa|psp TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}.
Q9BST9 RTKN S242 ochoa Rhotekin Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}.
Q9BTC0 DIDO1 S101 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9C073 FAM117A S67 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9C0C2 TNKS1BP1 S1029 ochoa 182 kDa tankyrase-1-binding protein None
Q9H3M7 TXNIP S361 ochoa|psp Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Q9H4A6 GOLPH3 S35 ochoa Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.
Q9H4L4 SENP3 S212 ochoa Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H7M9 VSIR S248 ochoa V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.
Q9HC77 CPAP S1125 ochoa Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}.
Q9HCC9 ZFYVE28 S378 ochoa Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}.
Q9NR09 BIRC6 S797 ochoa Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
Q9NVR5 DNAAF2 S467 ochoa Protein kintoun (Dynein assembly factor 2, axonemal) Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}.
Q9NYQ7 CELSR3 S3058 ochoa Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9P0U4 CXXC1 S263 ochoa CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.
Q9P2D0 IBTK S1039 ochoa Inhibitor of Bruton tyrosine kinase (IBtk) Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.
Q9UKI8 TLK1 S158 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9ULC4 MCTS1 S118 ochoa|psp Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies) Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation (PubMed:16982740, PubMed:20713520, PubMed:37875108). This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent (PubMed:16982740, PubMed:20713520, PubMed:37875108). Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair (PubMed:10440924, PubMed:11709712, PubMed:12637315, PubMed:15897892, PubMed:16322206, PubMed:17016429, PubMed:17416211, PubMed:9766643). Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2 (PubMed:37875108). {ECO:0000269|PubMed:10440924, ECO:0000269|PubMed:11709712, ECO:0000269|PubMed:12637315, ECO:0000269|PubMed:15897892, ECO:0000269|PubMed:16322206, ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17016429, ECO:0000269|PubMed:17416211, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:37875108, ECO:0000269|PubMed:9766643}.
Q9UPT8 ZC3H4 S1269 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9Y2J4 AMOTL2 S50 ochoa Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}.
Q9Y5V3 MAGED1 S322 ochoa Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
Q96RT7 TUBGCP6 S1176 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q01196 RUNX1 S397 SIGNOR Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.
P29353 SHC1 S28 SIGNOR SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}.
P08151 GLI1 S602 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P31327 CPS1 S597 Sugiyama Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
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reactome_id name p -log10_p
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 4.839911e-09 8.315
R-HSA-190872 Transport of connexons to the plasma membrane 6.549098e-09 8.184
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.153676e-08 7.938
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 3.957320e-08 7.403
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 9.954401e-08 7.002
R-HSA-9619483 Activation of AMPK downstream of NMDARs 9.178040e-08 7.037
R-HSA-381038 XBP1(S) activates chaperone genes 8.227435e-08 7.085
R-HSA-381070 IRE1alpha activates chaperones 1.438970e-07 6.842
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1.616021e-07 6.792
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 2.295694e-07 6.639
R-HSA-190861 Gap junction assembly 3.201674e-07 6.495
R-HSA-2262752 Cellular responses to stress 3.881147e-07 6.411
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.703990e-07 6.328
R-HSA-9646399 Aggrephagy 7.904389e-07 6.102
R-HSA-438064 Post NMDA receptor activation events 9.589641e-07 6.018
R-HSA-381119 Unfolded Protein Response (UPR) 9.448797e-07 6.025
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.039896e-06 5.983
R-HSA-8953897 Cellular responses to stimuli 1.385531e-06 5.858
R-HSA-190828 Gap junction trafficking 1.535657e-06 5.814
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.674432e-06 5.776
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 2.215475e-06 5.655
R-HSA-69275 G2/M Transition 2.045509e-06 5.689
R-HSA-453274 Mitotic G2-G2/M phases 2.257551e-06 5.646
R-HSA-437239 Recycling pathway of L1 2.215475e-06 5.655
R-HSA-157858 Gap junction trafficking and regulation 2.795708e-06 5.554
R-HSA-5610787 Hedgehog 'off' state 3.101867e-06 5.508
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 3.578819e-06 5.446
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 5.346632e-06 5.272
R-HSA-983189 Kinesins 8.737284e-06 5.059
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.051841e-05 4.978
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 1.558814e-05 4.807
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.268279e-05 4.644
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.655586e-05 4.576
R-HSA-5620924 Intraflagellar transport 3.119323e-05 4.506
R-HSA-5358351 Signaling by Hedgehog 4.244941e-05 4.372
R-HSA-9833482 PKR-mediated signaling 4.464375e-05 4.350
R-HSA-390466 Chaperonin-mediated protein folding 7.658661e-05 4.116
R-HSA-9663891 Selective autophagy 8.163797e-05 4.088
R-HSA-68877 Mitotic Prometaphase 8.913195e-05 4.050
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 9.322363e-05 4.030
R-HSA-391251 Protein folding 1.111417e-04 3.954
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.487847e-04 3.827
R-HSA-6807878 COPI-mediated anterograde transport 1.487847e-04 3.827
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 2.268923e-04 3.644
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.117283e-04 3.506
R-HSA-5617833 Cilium Assembly 3.886913e-04 3.410
R-HSA-373760 L1CAM interactions 4.765601e-04 3.322
R-HSA-210745 Regulation of gene expression in beta cells 5.380805e-04 3.269
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 5.944406e-04 3.226
R-HSA-2428933 SHC-related events triggered by IGF1R 6.736307e-04 3.172
R-HSA-9842663 Signaling by LTK 6.736307e-04 3.172
R-HSA-2132295 MHC class II antigen presentation 6.476233e-04 3.189
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.126674e-04 3.090
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 8.421374e-04 3.075
R-HSA-68882 Mitotic Anaphase 9.151244e-04 3.039
R-HSA-8856688 Golgi-to-ER retrograde transport 1.011413e-03 2.995
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.423142e-04 3.026
R-HSA-112315 Transmission across Chemical Synapses 1.039338e-03 2.983
R-HSA-68886 M Phase 1.165453e-03 2.934
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1.306861e-03 2.884
R-HSA-1632852 Macroautophagy 1.466588e-03 2.834
R-HSA-201556 Signaling by ALK 1.469465e-03 2.833
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.717316e-03 2.765
R-HSA-199977 ER to Golgi Anterograde Transport 1.870481e-03 2.728
R-HSA-380287 Centrosome maturation 1.908155e-03 2.719
R-HSA-9609690 HCMV Early Events 2.037806e-03 2.691
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.280984e-03 2.642
R-HSA-9612973 Autophagy 2.510926e-03 2.600
R-HSA-9634597 GPER1 signaling 2.978839e-03 2.526
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.963437e-03 2.528
R-HSA-2467813 Separation of Sister Chromatids 3.211277e-03 2.493
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 3.277652e-03 2.484
R-HSA-69278 Cell Cycle, Mitotic 3.599987e-03 2.444
R-HSA-1640170 Cell Cycle 4.232631e-03 2.373
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 5.194299e-03 2.284
R-HSA-1227986 Signaling by ERBB2 5.884150e-03 2.230
R-HSA-193704 p75 NTR receptor-mediated signalling 6.241607e-03 2.205
R-HSA-112316 Neuronal System 5.532257e-03 2.257
R-HSA-186712 Regulation of beta-cell development 5.589995e-03 2.253
R-HSA-1250196 SHC1 events in ERBB2 signaling 6.592435e-03 2.181
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 6.828045e-03 2.166
R-HSA-380259 Loss of Nlp from mitotic centrosomes 6.828045e-03 2.166
R-HSA-201688 WNT mediated activation of DVL 7.176366e-03 2.144
R-HSA-9609646 HCMV Infection 7.829185e-03 2.106
R-HSA-8854518 AURKA Activation by TPX2 7.867115e-03 2.104
R-HSA-9034864 Activated NTRK3 signals through RAS 9.635906e-03 2.016
R-HSA-9020558 Interleukin-2 signaling 9.635906e-03 2.016
R-HSA-2559585 Oncogene Induced Senescence 1.000548e-02 2.000
R-HSA-1852241 Organelle biogenesis and maintenance 9.860206e-03 2.006
R-HSA-948021 Transport to the Golgi and subsequent modification 8.955300e-03 2.048
R-HSA-5467343 Deletions in the AMER1 gene destabilize the destruction complex 1.037893e-02 1.984
R-HSA-9026519 Activated NTRK2 signals through RAS 1.098677e-02 1.959
R-HSA-4839748 Signaling by AMER1 mutants 1.098677e-02 1.959
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.241597e-02 1.906
R-HSA-209543 p75NTR recruits signalling complexes 1.241597e-02 1.906
R-HSA-8983432 Interleukin-15 signaling 1.241597e-02 1.906
R-HSA-8951936 RUNX3 regulates p14-ARF 1.241597e-02 1.906
R-HSA-162582 Signal Transduction 1.292927e-02 1.888
R-HSA-193639 p75NTR signals via NF-kB 1.715628e-02 1.766
R-HSA-446353 Cell-extracellular matrix interactions 1.715628e-02 1.766
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 1.715628e-02 1.766
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.067305e-02 1.685
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.888163e-02 1.724
R-HSA-9664420 Killing mechanisms 1.888163e-02 1.724
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 1.888163e-02 1.724
R-HSA-1280215 Cytokine Signaling in Immune system 2.056030e-02 1.687
R-HSA-9665348 Signaling by ERBB2 ECD mutants 2.447036e-02 1.611
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.447036e-02 1.611
R-HSA-4419969 Depolymerization of the Nuclear Lamina 2.447036e-02 1.611
R-HSA-9831926 Nephron development 2.447036e-02 1.611
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 2.447036e-02 1.611
R-HSA-5654704 SHC-mediated cascade:FGFR3 3.064497e-02 1.514
R-HSA-193648 NRAGE signals death through JNK 3.002687e-02 1.522
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 3.064497e-02 1.514
R-HSA-1221632 Meiotic synapsis 2.658661e-02 1.575
R-HSA-198753 ERK/MAPK targets 3.064497e-02 1.514
R-HSA-8878159 Transcriptional regulation by RUNX3 2.727608e-02 1.564
R-HSA-9009391 Extra-nuclear estrogen signaling 3.057130e-02 1.515
R-HSA-5654736 Signaling by FGFR1 3.002687e-02 1.522
R-HSA-913531 Interferon Signaling 2.673614e-02 1.573
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 4.087756e-02 1.389
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 4.087756e-02 1.389
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 4.087756e-02 1.389
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 4.087756e-02 1.389
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 4.087756e-02 1.389
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 4.087756e-02 1.389
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 4.087756e-02 1.389
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 4.087756e-02 1.389
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 4.087756e-02 1.389
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 4.087756e-02 1.389
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 4.087756e-02 1.389
R-HSA-5654719 SHC-mediated cascade:FGFR4 3.282624e-02 1.484
R-HSA-912526 Interleukin receptor SHC signaling 3.736450e-02 1.428
R-HSA-5654688 SHC-mediated cascade:FGFR1 3.971863e-02 1.401
R-HSA-429947 Deadenylation of mRNA 3.971863e-02 1.401
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 3.971863e-02 1.401
R-HSA-9839397 TGFBR3 regulates FGF2 signaling 3.081661e-02 1.511
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 4.087756e-02 1.389
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.506656e-02 1.455
R-HSA-352238 Breakdown of the nuclear lamina 3.081661e-02 1.511
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 3.971863e-02 1.401
R-HSA-2428924 IGF1R signaling cascade 4.028744e-02 1.395
R-HSA-9034015 Signaling by NTRK3 (TRKC) 3.282624e-02 1.484
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 3.282624e-02 1.484
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.506656e-02 1.455
R-HSA-450294 MAP kinase activation 3.625604e-02 1.441
R-HSA-73887 Death Receptor Signaling 3.515767e-02 1.454
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 3.471127e-02 1.460
R-HSA-166520 Signaling by NTRKs 3.090582e-02 1.510
R-HSA-422475 Axon guidance 3.601797e-02 1.443
R-HSA-1266738 Developmental Biology 3.478286e-02 1.459
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.167965e-02 1.380
R-HSA-9830369 Kidney development 4.453599e-02 1.351
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 4.458991e-02 1.351
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 4.458991e-02 1.351
R-HSA-525793 Myogenesis 4.458991e-02 1.351
R-HSA-5654699 SHC-mediated cascade:FGFR2 4.710433e-02 1.327
R-HSA-9006115 Signaling by NTRK2 (TRKB) 4.710433e-02 1.327
R-HSA-448424 Interleukin-17 signaling 4.899846e-02 1.310
R-HSA-9664565 Signaling by ERBB2 KD Mutants 5.228405e-02 1.282
R-HSA-5654708 Downstream signaling of activated FGFR3 5.228405e-02 1.282
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 5.228405e-02 1.282
R-HSA-9675108 Nervous system development 5.234793e-02 1.281
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 5.367120e-02 1.270
R-HSA-8939211 ESR-mediated signaling 5.376228e-02 1.270
R-HSA-1227990 Signaling by ERBB2 in Cancer 5.494676e-02 1.260
R-HSA-5654716 Downstream signaling of activated FGFR4 5.494676e-02 1.260
R-HSA-2559583 Cellular Senescence 5.862158e-02 1.232
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 7.044170e-02 1.152
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 7.044170e-02 1.152
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 8.009369e-02 1.096
R-HSA-164525 Plus-strand DNA synthesis 8.009369e-02 1.096
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 8.964605e-02 1.047
R-HSA-162585 Uncoating of the HIV Virion 8.964605e-02 1.047
R-HSA-4641258 Degradation of DVL 7.783351e-02 1.109
R-HSA-3371568 Attenuation phase 8.706553e-02 1.060
R-HSA-451927 Interleukin-2 family signaling 8.706553e-02 1.060
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 9.021277e-02 1.045
R-HSA-4791275 Signaling by WNT in cancer 6.041153e-02 1.219
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 6.068904e-02 1.217
R-HSA-6794362 Protein-protein interactions at synapses 7.437889e-02 1.129
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 8.009369e-02 1.096
R-HSA-5654696 Downstream signaling of activated FGFR2 7.186431e-02 1.143
R-HSA-5654687 Downstream signaling of activated FGFR1 7.186431e-02 1.143
R-HSA-9845576 Glycosphingolipid transport 7.482963e-02 1.126
R-HSA-3214841 PKMTs methylate histone lysines 9.021277e-02 1.045
R-HSA-1500620 Meiosis 7.437889e-02 1.129
R-HSA-9958790 SLC-mediated transport of inorganic anions 8.087484e-02 1.092
R-HSA-111465 Apoptotic cleavage of cellular proteins 6.041153e-02 1.219
R-HSA-9768919 NPAS4 regulates expression of target genes 6.893869e-02 1.162
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 9.660582e-02 1.015
R-HSA-162589 Reverse Transcription of HIV RNA 1.084560e-01 0.965
R-HSA-164516 Minus-strand DNA synthesis 1.084560e-01 0.965
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 1.084560e-01 0.965
R-HSA-446107 Type I hemidesmosome assembly 1.084560e-01 0.965
R-HSA-9700645 ALK mutants bind TKIs 1.177155e-01 0.929
R-HSA-173107 Binding and entry of HIV virion 1.268795e-01 0.897
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.359488e-01 0.867
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.359488e-01 0.867
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.359488e-01 0.867
R-HSA-5339716 Signaling by GSK3beta mutants 1.449245e-01 0.839
R-HSA-937039 IRAK1 recruits IKK complex 1.538075e-01 0.813
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.538075e-01 0.813
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.538075e-01 0.813
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.538075e-01 0.813
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.538075e-01 0.813
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.538075e-01 0.813
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.538075e-01 0.813
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.538075e-01 0.813
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1.625988e-01 0.789
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.799098e-01 0.745
R-HSA-196299 Beta-catenin phosphorylation cascade 1.799098e-01 0.745
R-HSA-180336 SHC1 events in EGFR signaling 1.799098e-01 0.745
R-HSA-1250347 SHC1 events in ERBB4 signaling 1.968651e-01 0.706
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 9.909980e-02 1.004
R-HSA-9020958 Interleukin-21 signaling 1.177155e-01 0.929
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.968651e-01 0.706
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocy... 1.084560e-01 0.965
R-HSA-9027284 Erythropoietin activates RAS 1.799098e-01 0.745
R-HSA-174430 Telomere C-strand synthesis initiation 1.799098e-01 0.745
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 1.084560e-01 0.965
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 1.449245e-01 0.839
R-HSA-3371571 HSF1-dependent transactivation 1.268082e-01 0.897
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 1.449245e-01 0.839
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 1.968651e-01 0.706
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.959987e-01 0.708
R-HSA-8985947 Interleukin-9 signaling 1.084560e-01 0.965
R-HSA-190370 FGFR1b ligand binding and activation 1.084560e-01 0.965
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.177155e-01 0.929
R-HSA-428543 Inactivation of CDC42 and RAC1 1.177155e-01 0.929
R-HSA-4839744 Signaling by APC mutants 1.359488e-01 0.867
R-HSA-209560 NF-kB is activated and signals survival 1.449245e-01 0.839
R-HSA-4839735 Signaling by AXIN mutants 1.449245e-01 0.839
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.625988e-01 0.789
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.922342e-01 0.716
R-HSA-74749 Signal attenuation 1.268795e-01 0.897
R-HSA-9761174 Formation of intermediate mesoderm 1.268795e-01 0.897
R-HSA-8851805 MET activates RAS signaling 1.538075e-01 0.813
R-HSA-429914 Deadenylation-dependent mRNA decay 1.552385e-01 0.809
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 1.798660e-01 0.745
R-HSA-2025928 Calcineurin activates NFAT 1.177155e-01 0.929
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 1.268795e-01 0.897
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 1.625988e-01 0.789
R-HSA-190373 FGFR1c ligand binding and activation 1.625988e-01 0.789
R-HSA-445355 Smooth Muscle Contraction 1.337946e-01 0.874
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 1.625988e-01 0.789
R-HSA-975155 MyD88 dependent cascade initiated on endosome 1.336823e-01 0.874
R-HSA-9839389 TGFBR3 regulates TGF-beta signaling 9.909980e-02 1.004
R-HSA-425381 Bicarbonate transporters 1.359488e-01 0.867
R-HSA-2980766 Nuclear Envelope Breakdown 1.480161e-01 0.830
R-HSA-975871 MyD88 cascade initiated on plasma membrane 1.065737e-01 0.972
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 1.065737e-01 0.972
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 1.065737e-01 0.972
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.432053e-01 0.844
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 1.661948e-01 0.779
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 1.504918e-01 0.822
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1.628923e-01 0.788
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 1.628923e-01 0.788
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 1.704762e-01 0.768
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 1.359488e-01 0.867
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.064269e-01 0.973
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 1.704762e-01 0.768
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.313375e-01 0.882
R-HSA-449147 Signaling by Interleukins 1.397498e-01 0.855
R-HSA-162592 Integration of provirus 1.449245e-01 0.839
R-HSA-418555 G alpha (s) signalling events 1.386006e-01 0.858
R-HSA-190236 Signaling by FGFR 1.065737e-01 0.972
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 1.177155e-01 0.929
R-HSA-445717 Aquaporin-mediated transport 1.625274e-01 0.789
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.538075e-01 0.813
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1.177155e-01 0.929
R-HSA-177929 Signaling by EGFR 1.444317e-01 0.840
R-HSA-5654743 Signaling by FGFR4 9.984963e-02 1.001
R-HSA-5654741 Signaling by FGFR3 1.064269e-01 0.973
R-HSA-187037 Signaling by NTRK1 (TRKA) 1.885509e-01 0.725
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.064269e-01 0.973
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 1.735725e-01 0.761
R-HSA-9700206 Signaling by ALK in cancer 1.290075e-01 0.889
R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 9.984963e-02 1.001
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.290075e-01 0.889
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.360417e-01 0.866
R-HSA-166166 MyD88-independent TLR4 cascade 1.360417e-01 0.866
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1.243928e-01 0.905
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 1.302904e-01 0.885
R-HSA-9945266 Differentiation of T cells 1.884315e-01 0.725
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 1.884315e-01 0.725
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.480161e-01 0.830
R-HSA-1474165 Reproduction 1.964449e-01 0.707
R-HSA-75105 Fatty acyl-CoA biosynthesis 1.959987e-01 0.708
R-HSA-9856651 MITF-M-dependent gene expression 1.002119e-01 0.999
R-HSA-75153 Apoptotic execution phase 1.097584e-01 0.960
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 1.772813e-01 0.751
R-HSA-9634815 Transcriptional Regulation by NPAS4 1.302904e-01 0.885
R-HSA-446203 Asparagine N-linked glycosylation 1.822740e-01 0.739
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.989646e-01 0.701
R-HSA-5632684 Hedgehog 'on' state 1.997725e-01 0.699
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 2.035550e-01 0.691
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 2.035550e-01 0.691
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 2.052116e-01 0.688
R-HSA-5637810 Constitutive Signaling by EGFRvIII 2.052116e-01 0.688
R-HSA-5637812 Signaling by EGFRvIII in Cancer 2.052116e-01 0.688
R-HSA-2028269 Signaling by Hippo 2.052116e-01 0.688
R-HSA-9006931 Signaling by Nuclear Receptors 2.123040e-01 0.673
R-HSA-163615 PKA activation 2.134719e-01 0.671
R-HSA-164378 PKA activation in glucagon signalling 2.134719e-01 0.671
R-HSA-190242 FGFR1 ligand binding and activation 2.134719e-01 0.671
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.134719e-01 0.671
R-HSA-180292 GAB1 signalosome 2.134719e-01 0.671
R-HSA-210993 Tie2 Signaling 2.134719e-01 0.671
R-HSA-1169408 ISG15 antiviral mechanism 2.149487e-01 0.668
R-HSA-9020591 Interleukin-12 signaling 2.187602e-01 0.660
R-HSA-109582 Hemostasis 2.210079e-01 0.656
R-HSA-844456 The NLRP3 inflammasome 2.216468e-01 0.654
R-HSA-5673001 RAF/MAP kinase cascade 2.222692e-01 0.653
R-HSA-4086400 PCP/CE pathway 2.264003e-01 0.645
R-HSA-416482 G alpha (12/13) signalling events 2.264003e-01 0.645
R-HSA-9730414 MITF-M-regulated melanocyte development 2.268688e-01 0.644
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 2.297373e-01 0.639
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2.297373e-01 0.639
R-HSA-5654738 Signaling by FGFR2 2.340598e-01 0.631
R-HSA-5684996 MAPK1/MAPK3 signaling 2.355402e-01 0.628
R-HSA-162594 Early Phase of HIV Life Cycle 2.377442e-01 0.624
R-HSA-167044 Signalling to RAS 2.377442e-01 0.624
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.377442e-01 0.624
R-HSA-111931 PKA-mediated phosphorylation of CREB 2.377442e-01 0.624
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 2.377442e-01 0.624
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 2.377442e-01 0.624
R-HSA-210991 Basigin interactions 2.377442e-01 0.624
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 2.456683e-01 0.610
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 2.456683e-01 0.610
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 2.456683e-01 0.610
R-HSA-175474 Assembly Of The HIV Virion 2.456683e-01 0.610
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 2.508351e-01 0.601
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 2.535105e-01 0.596
R-HSA-166208 mTORC1-mediated signalling 2.535105e-01 0.596
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2.612717e-01 0.583
R-HSA-9830674 Formation of the ureteric bud 2.612717e-01 0.583
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 2.619912e-01 0.582
R-HSA-70268 Pyruvate metabolism 2.648129e-01 0.577
R-HSA-447115 Interleukin-12 family signaling 2.648129e-01 0.577
R-HSA-199991 Membrane Trafficking 2.653852e-01 0.576
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.689527e-01 0.570
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.689527e-01 0.570
R-HSA-8863678 Neurodegenerative Diseases 2.689527e-01 0.570
R-HSA-112310 Neurotransmitter release cycle 2.763604e-01 0.559
R-HSA-174411 Polymerase switching on the C-strand of the telomere 2.765542e-01 0.558
R-HSA-1266695 Interleukin-7 signaling 2.765542e-01 0.558
R-HSA-400685 Sema4D in semaphorin signaling 2.765542e-01 0.558
R-HSA-8986944 Transcriptional Regulation by MECP2 2.802080e-01 0.553
R-HSA-1643713 Signaling by EGFR in Cancer 2.840772e-01 0.547
R-HSA-70635 Urea cycle 2.840772e-01 0.547
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 2.840772e-01 0.547
R-HSA-109581 Apoptosis 2.901314e-01 0.537
R-HSA-174414 Processive synthesis on the C-strand of the telomere 2.915225e-01 0.535
R-HSA-171306 Packaging Of Telomere Ends 2.915225e-01 0.535
R-HSA-3928663 EPHA-mediated growth cone collapse 2.915225e-01 0.535
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 2.915225e-01 0.535
R-HSA-171319 Telomere Extension By Telomerase 2.988907e-01 0.524
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 2.988907e-01 0.524
R-HSA-622312 Inflammasomes 2.988907e-01 0.524
R-HSA-9006335 Signaling by Erythropoietin 3.061828e-01 0.514
R-HSA-180024 DARPP-32 events 3.061828e-01 0.514
R-HSA-9674555 Signaling by CSF3 (G-CSF) 3.061828e-01 0.514
R-HSA-2424491 DAP12 signaling 3.133995e-01 0.504
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.133995e-01 0.504
R-HSA-8863795 Downregulation of ERBB2 signaling 3.133995e-01 0.504
R-HSA-9614085 FOXO-mediated transcription 3.185447e-01 0.497
R-HSA-162588 Budding and maturation of HIV virion 3.205415e-01 0.494
R-HSA-70171 Glycolysis 3.223568e-01 0.492
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 3.276097e-01 0.485
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 3.276097e-01 0.485
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 3.346049e-01 0.475
R-HSA-9930044 Nuclear RNA decay 3.346049e-01 0.475
R-HSA-354192 Integrin signaling 3.346049e-01 0.475
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.346049e-01 0.475
R-HSA-5683057 MAPK family signaling cascades 3.373728e-01 0.472
R-HSA-163359 Glucagon signaling in metabolic regulation 3.415276e-01 0.467
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 3.483788e-01 0.458
R-HSA-168638 NOD1/2 Signaling Pathway 3.483788e-01 0.458
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 3.483788e-01 0.458
R-HSA-9692914 SARS-CoV-1-host interactions 3.488786e-01 0.457
R-HSA-201681 TCF dependent signaling in response to WNT 3.525556e-01 0.453
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.551591e-01 0.450
R-HSA-187687 Signalling to ERKs 3.551591e-01 0.450
R-HSA-381042 PERK regulates gene expression 3.551591e-01 0.450
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.618693e-01 0.441
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.618693e-01 0.441
R-HSA-74158 RNA Polymerase III Transcription 3.618693e-01 0.441
R-HSA-8853659 RET signaling 3.618693e-01 0.441
R-HSA-3371511 HSF1 activation 3.618693e-01 0.441
R-HSA-111933 Calmodulin induced events 3.618693e-01 0.441
R-HSA-111997 CaM pathway 3.618693e-01 0.441
R-HSA-110331 Cleavage of the damaged purine 3.685100e-01 0.434
R-HSA-549127 SLC-mediated transport of organic cations 3.685100e-01 0.434
R-HSA-73927 Depurination 3.750821e-01 0.426
R-HSA-168898 Toll-like Receptor Cascades 3.751779e-01 0.426
R-HSA-446728 Cell junction organization 3.773921e-01 0.423
R-HSA-9658195 Leishmania infection 3.844548e-01 0.415
R-HSA-9824443 Parasitic Infection Pathways 3.844548e-01 0.415
R-HSA-9670095 Inhibition of DNA recombination at telomere 3.880229e-01 0.411
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.898141e-01 0.409
R-HSA-9007101 Rab regulation of trafficking 3.971391e-01 0.401
R-HSA-70326 Glucose metabolism 3.971391e-01 0.401
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 4.006973e-01 0.397
R-HSA-5610780 Degradation of GLI1 by the proteasome 4.006973e-01 0.397
R-HSA-6811438 Intra-Golgi traffic 4.006973e-01 0.397
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 4.069363e-01 0.390
R-HSA-111996 Ca-dependent events 4.069363e-01 0.390
R-HSA-110329 Cleavage of the damaged pyrimidine 4.069363e-01 0.390
R-HSA-73928 Depyrimidination 4.069363e-01 0.390
R-HSA-165159 MTOR signalling 4.069363e-01 0.390
R-HSA-68875 Mitotic Prophase 4.080507e-01 0.389
R-HSA-3371556 Cellular response to heat stress 4.116669e-01 0.385
R-HSA-8854214 TBC/RABGAPs 4.131107e-01 0.384
R-HSA-5357801 Programmed Cell Death 4.171296e-01 0.380
R-HSA-9816359 Maternal to zygotic transition (MZT) 4.188667e-01 0.378
R-HSA-2172127 DAP12 interactions 4.192213e-01 0.378
R-HSA-375280 Amine ligand-binding receptors 4.192213e-01 0.378
R-HSA-195721 Signaling by WNT 4.242514e-01 0.372
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 4.252686e-01 0.371
R-HSA-76009 Platelet Aggregation (Plug Formation) 4.252686e-01 0.371
R-HSA-1489509 DAG and IP3 signaling 4.252686e-01 0.371
R-HSA-194138 Signaling by VEGF 4.295827e-01 0.367
R-HSA-9839373 Signaling by TGFBR3 4.312532e-01 0.365
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 4.312532e-01 0.365
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 4.312532e-01 0.365
R-HSA-9861718 Regulation of pyruvate metabolism 4.312532e-01 0.365
R-HSA-114608 Platelet degranulation 4.366690e-01 0.360
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 4.371760e-01 0.359
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 4.371760e-01 0.359
R-HSA-9031628 NGF-stimulated transcription 4.430374e-01 0.354
R-HSA-5658442 Regulation of RAS by GAPs 4.545788e-01 0.342
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 4.602601e-01 0.337
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.610910e-01 0.336
R-HSA-1500931 Cell-Cell communication 4.656869e-01 0.332
R-HSA-72187 mRNA 3'-end processing 4.658825e-01 0.332
R-HSA-6794361 Neurexins and neuroligins 4.658825e-01 0.332
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 4.658825e-01 0.332
R-HSA-9639288 Amino acids regulate mTORC1 4.714467e-01 0.327
R-HSA-9018519 Estrogen-dependent gene expression 4.747691e-01 0.324
R-HSA-3858494 Beta-catenin independent WNT signaling 4.747691e-01 0.324
R-HSA-72649 Translation initiation complex formation 4.769532e-01 0.322
R-HSA-73929 Base-Excision Repair, AP Site Formation 4.769532e-01 0.322
R-HSA-72702 Ribosomal scanning and start codon recognition 4.877959e-01 0.312
R-HSA-3299685 Detoxification of Reactive Oxygen Species 4.877959e-01 0.312
R-HSA-3247509 Chromatin modifying enzymes 4.953161e-01 0.305
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 4.984151e-01 0.302
R-HSA-5653656 Vesicle-mediated transport 4.995957e-01 0.301
R-HSA-180786 Extension of Telomeres 5.036423e-01 0.298
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 5.036423e-01 0.298
R-HSA-8873719 RAB geranylgeranylation 5.088154e-01 0.293
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 5.088154e-01 0.293
R-HSA-73856 RNA Polymerase II Transcription Termination 5.139348e-01 0.289
R-HSA-112043 PLC beta mediated events 5.139348e-01 0.289
R-HSA-6784531 tRNA processing in the nucleus 5.190013e-01 0.285
R-HSA-9616222 Transcriptional regulation of granulopoiesis 5.190013e-01 0.285
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 5.240152e-01 0.281
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.240152e-01 0.281
R-HSA-8848021 Signaling by PTK6 5.240152e-01 0.281
R-HSA-373755 Semaphorin interactions 5.240152e-01 0.281
R-HSA-74751 Insulin receptor signalling cascade 5.289772e-01 0.277
R-HSA-4839726 Chromatin organization 5.336953e-01 0.273
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.338877e-01 0.273
R-HSA-1234174 Cellular response to hypoxia 5.338877e-01 0.273
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 5.367817e-01 0.270
R-HSA-6782315 tRNA modification in the nucleus and cytosol 5.387474e-01 0.269
R-HSA-9824446 Viral Infection Pathways 5.399188e-01 0.268
R-HSA-112040 G-protein mediated events 5.435567e-01 0.265
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.483161e-01 0.261
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.576875e-01 0.254
R-HSA-9764560 Regulation of CDH1 Gene Transcription 5.576875e-01 0.254
R-HSA-9734767 Developmental Cell Lineages 5.680051e-01 0.246
R-HSA-1236394 Signaling by ERBB4 5.758543e-01 0.240
R-HSA-1222556 ROS and RNS production in phagocytes 5.758543e-01 0.240
R-HSA-9711123 Cellular response to chemical stress 5.798815e-01 0.237
R-HSA-8852135 Protein ubiquitination 5.802789e-01 0.236
R-HSA-917937 Iron uptake and transport 5.802789e-01 0.236
R-HSA-72306 tRNA processing 5.878839e-01 0.231
R-HSA-388396 GPCR downstream signalling 5.916903e-01 0.228
R-HSA-383280 Nuclear Receptor transcription pathway 5.932793e-01 0.227
R-HSA-76002 Platelet activation, signaling and aggregation 5.938617e-01 0.226
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 5.975232e-01 0.224
R-HSA-6806834 Signaling by MET 6.017230e-01 0.221
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 6.017230e-01 0.221
R-HSA-9678108 SARS-CoV-1 Infection 6.021029e-01 0.220
R-HSA-9707564 Cytoprotection by HMOX1 6.140630e-01 0.212
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.180912e-01 0.209
R-HSA-6802957 Oncogenic MAPK signaling 6.220777e-01 0.206
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 6.260228e-01 0.203
R-HSA-9645723 Diseases of programmed cell death 6.376141e-01 0.195
R-HSA-73884 Base Excision Repair 6.451425e-01 0.190
R-HSA-1912408 Pre-NOTCH Transcription and Translation 6.488482e-01 0.188
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.525155e-01 0.185
R-HSA-74752 Signaling by Insulin receptor 6.561446e-01 0.183
R-HSA-2682334 EPH-Ephrin signaling 6.561446e-01 0.183
R-HSA-1474290 Collagen formation 6.632903e-01 0.178
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 6.737329e-01 0.172
R-HSA-8953854 Metabolism of RNA 6.741921e-01 0.171
R-HSA-376176 Signaling by ROBO receptors 6.749255e-01 0.171
R-HSA-157579 Telomere Maintenance 6.771418e-01 0.169
R-HSA-8957275 Post-translational protein phosphorylation 6.805152e-01 0.167
R-HSA-422356 Regulation of insulin secretion 6.805152e-01 0.167
R-HSA-3214847 HATs acetylate histones 6.838536e-01 0.165
R-HSA-9020702 Interleukin-1 signaling 6.904267e-01 0.161
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.936621e-01 0.159
R-HSA-397014 Muscle contraction 6.981937e-01 0.156
R-HSA-9860931 Response of endothelial cells to shear stress 7.000325e-01 0.155
R-HSA-111885 Opioid Signalling 7.000325e-01 0.155
R-HSA-372790 Signaling by GPCR 7.013623e-01 0.154
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.031681e-01 0.153
R-HSA-5619507 Activation of HOX genes during differentiation 7.031681e-01 0.153
R-HSA-5663205 Infectious disease 7.153288e-01 0.145
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.153881e-01 0.145
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.153881e-01 0.145
R-HSA-1236975 Antigen processing-Cross presentation 7.153881e-01 0.145
R-HSA-927802 Nonsense-Mediated Decay (NMD) 7.271079e-01 0.138
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 7.271079e-01 0.138
R-HSA-2871796 FCERI mediated MAPK activation 7.271079e-01 0.138
R-HSA-8878171 Transcriptional regulation by RUNX1 7.284484e-01 0.138
R-HSA-1912422 Pre-NOTCH Expression and Processing 7.299620e-01 0.137
R-HSA-9855142 Cellular responses to mechanical stimuli 7.327866e-01 0.135
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 7.355817e-01 0.133
R-HSA-2871809 FCERI mediated Ca+2 mobilization 7.410851e-01 0.130
R-HSA-72737 Cap-dependent Translation Initiation 7.437939e-01 0.129
R-HSA-72613 Eukaryotic Translation Initiation 7.437939e-01 0.129
R-HSA-202733 Cell surface interactions at the vascular wall 7.503943e-01 0.125
R-HSA-8878166 Transcriptional regulation by RUNX2 7.517526e-01 0.124
R-HSA-73886 Chromosome Maintenance 7.569214e-01 0.121
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.619831e-01 0.118
R-HSA-162909 Host Interactions of HIV factors 7.644746e-01 0.117
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.693799e-01 0.114
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.693799e-01 0.114
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.693799e-01 0.114
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 7.717944e-01 0.112
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.812036e-01 0.107
R-HSA-1280218 Adaptive Immune System 7.886795e-01 0.103
R-HSA-416476 G alpha (q) signalling events 7.979114e-01 0.098
R-HSA-163685 Integration of energy metabolism 7.988805e-01 0.098
R-HSA-162599 Late Phase of HIV Life Cycle 8.131786e-01 0.090
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 8.131786e-01 0.090
R-HSA-425407 SLC-mediated transmembrane transport 8.139186e-01 0.089
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 8.207199e-01 0.086
R-HSA-9758941 Gastrulation 8.264659e-01 0.083
R-HSA-382551 Transport of small molecules 8.265086e-01 0.083
R-HSA-9679191 Potential therapeutics for SARS 8.282858e-01 0.082
R-HSA-9755511 KEAP1-NFE2L2 pathway 8.300867e-01 0.081
R-HSA-446652 Interleukin-1 family signaling 8.318688e-01 0.080
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.318688e-01 0.080
R-HSA-9609507 Protein localization 8.336324e-01 0.079
R-HSA-1989781 PPARA activates gene expression 8.371045e-01 0.077
R-HSA-162587 HIV Life Cycle 8.405046e-01 0.075
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 8.405046e-01 0.075
R-HSA-74160 Gene expression (Transcription) 8.413912e-01 0.075
R-HSA-9711097 Cellular response to starvation 8.421780e-01 0.075
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 8.421780e-01 0.075
R-HSA-9006936 Signaling by TGFB family members 8.454728e-01 0.073
R-HSA-212436 Generic Transcription Pathway 8.459980e-01 0.073
R-HSA-9679506 SARS-CoV Infections 8.544583e-01 0.068
R-HSA-1643685 Disease 8.576411e-01 0.067
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 8.624089e-01 0.064
R-HSA-73857 RNA Polymerase II Transcription 8.660587e-01 0.062
R-HSA-9664433 Leishmania parasite growth and survival 8.666986e-01 0.062
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.666986e-01 0.062
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.666986e-01 0.062
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.666986e-01 0.062
R-HSA-212165 Epigenetic regulation of gene expression 8.749316e-01 0.058
R-HSA-168256 Immune System 8.765014e-01 0.057
R-HSA-6798695 Neutrophil degranulation 8.780291e-01 0.056
R-HSA-375276 Peptide ligand-binding receptors 8.838023e-01 0.054
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.862325e-01 0.052
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.924278e-01 0.049
R-HSA-72163 mRNA Splicing - Major Pathway 8.932240e-01 0.049
R-HSA-9006925 Intracellular signaling by second messengers 8.933303e-01 0.049
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.954583e-01 0.048
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 9.029184e-01 0.044
R-HSA-72172 mRNA Splicing 9.049510e-01 0.043
R-HSA-418990 Adherens junctions interactions 9.180419e-01 0.037
R-HSA-8951664 Neddylation 9.206049e-01 0.036
R-HSA-162906 HIV Infection 9.254942e-01 0.034
R-HSA-9705683 SARS-CoV-2-host interactions 9.262795e-01 0.033
R-HSA-72312 rRNA processing 9.293392e-01 0.032
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.322447e-01 0.030
R-HSA-157118 Signaling by NOTCH 9.350849e-01 0.029
R-HSA-418594 G alpha (i) signalling events 9.395050e-01 0.027
R-HSA-8978868 Fatty acid metabolism 9.395050e-01 0.027
R-HSA-421270 Cell-cell junction organization 9.422343e-01 0.026
R-HSA-168249 Innate Immune System 9.479690e-01 0.023
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.604341e-01 0.018
R-HSA-1257604 PIP3 activates AKT signaling 9.638078e-01 0.016
R-HSA-3700989 Transcriptional Regulation by TP53 9.638244e-01 0.016
R-HSA-597592 Post-translational protein modification 9.688935e-01 0.014
R-HSA-8957322 Metabolism of steroids 9.734250e-01 0.012
R-HSA-1474244 Extracellular matrix organization 9.753364e-01 0.011
R-HSA-9694516 SARS-CoV-2 Infection 9.796467e-01 0.009
R-HSA-73894 DNA Repair 9.819029e-01 0.008
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.859992e-01 0.006
R-HSA-500792 GPCR ligand binding 9.884103e-01 0.005
R-HSA-72766 Translation 9.914483e-01 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 9.988890e-01 0.000
R-HSA-392499 Metabolism of proteins 9.994436e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999889e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.763 0.418 1 0.903
HIPK2HIPK2 0.758 0.420 1 0.921
CDK18CDK18 0.757 0.464 1 0.923
CDK19CDK19 0.755 0.437 1 0.910
P38GP38G 0.751 0.460 1 0.907
HIPK4HIPK4 0.750 0.345 1 0.805
JNK2JNK2 0.749 0.457 1 0.911
DYRK2DYRK2 0.748 0.406 1 0.904
CDK8CDK8 0.747 0.418 1 0.906
CDK7CDK7 0.746 0.426 1 0.922
CDK1CDK1 0.746 0.409 1 0.921
P38DP38D 0.745 0.441 1 0.918
CDK3CDK3 0.744 0.390 1 0.919
CDK13CDK13 0.743 0.428 1 0.923
CDK17CDK17 0.743 0.437 1 0.911
CLK3CLK3 0.742 0.264 1 0.793
CDK12CDK12 0.742 0.439 1 0.919
JNK3JNK3 0.742 0.435 1 0.917
P38BP38B 0.741 0.437 1 0.890
DYRK4DYRK4 0.741 0.396 1 0.927
CDK5CDK5 0.740 0.422 1 0.920
HIPK1HIPK1 0.738 0.376 1 0.903
ERK1ERK1 0.737 0.414 1 0.901
P38AP38A 0.737 0.434 1 0.895
CDK16CDK16 0.735 0.420 1 0.912
PRP4PRP4 0.734 0.463 -3 0.868
CDK9CDK9 0.734 0.411 1 0.923
SRPK1SRPK1 0.733 0.186 -3 0.584
CLK2CLK2 0.733 0.242 -3 0.565
MTORMTOR 0.730 0.255 1 0.645
DYRK1BDYRK1B 0.729 0.363 1 0.927
CDK14CDK14 0.729 0.410 1 0.921
CDK10CDK10 0.728 0.368 1 0.931
COTCOT 0.728 0.096 2 0.737
NLKNLK 0.726 0.342 1 0.819
DYRK1ADYRK1A 0.725 0.309 1 0.891
HIPK3HIPK3 0.724 0.348 1 0.873
JNK1JNK1 0.723 0.380 1 0.914
MOSMOS 0.720 0.112 1 0.611
ERK5ERK5 0.719 0.198 1 0.733
MAKMAK 0.719 0.297 -2 0.724
DYRK3DYRK3 0.718 0.281 1 0.882
CDC7CDC7 0.717 0.027 1 0.563
SRPK2SRPK2 0.716 0.119 -3 0.506
ICKICK 0.715 0.198 -3 0.644
CLK4CLK4 0.714 0.187 -3 0.581
CDKL5CDKL5 0.714 0.101 -3 0.609
CDK2CDK2 0.713 0.287 1 0.882
PRKD1PRKD1 0.713 0.121 -3 0.651
CLK1CLK1 0.713 0.193 -3 0.555
ERK2ERK2 0.713 0.359 1 0.896
NDR2NDR2 0.712 0.048 -3 0.638
CDK6CDK6 0.711 0.372 1 0.924
CDKL1CDKL1 0.711 0.086 -3 0.612
PIM3PIM3 0.711 0.032 -3 0.640
PRPKPRPK 0.710 0.041 -1 0.625
CDK4CDK4 0.710 0.382 1 0.916
NEK6NEK6 0.709 0.035 -2 0.775
SKMLCKSKMLCK 0.708 0.074 -2 0.787
SRPK3SRPK3 0.706 0.098 -3 0.548
CHAK2CHAK2 0.706 0.063 -1 0.561
ATRATR 0.705 0.004 1 0.569
DSTYKDSTYK 0.704 -0.021 2 0.761
PDHK4PDHK4 0.704 -0.050 1 0.588
AURCAURC 0.703 0.052 -2 0.567
GCN2GCN2 0.703 -0.071 2 0.664
MOKMOK 0.702 0.246 1 0.843
MST4MST4 0.702 0.045 2 0.785
RAF1RAF1 0.701 -0.060 1 0.537
TBK1TBK1 0.701 -0.039 1 0.456
GRK1GRK1 0.701 0.001 -2 0.684
PRKD2PRKD2 0.701 0.048 -3 0.589
IKKEIKKE 0.700 -0.031 1 0.448
IKKBIKKB 0.700 -0.079 -2 0.629
MARK4MARK4 0.700 0.069 4 0.743
GRK7GRK7 0.700 0.042 1 0.536
IKKAIKKA 0.699 0.003 -2 0.632
PDHK1PDHK1 0.699 -0.037 1 0.551
GSK3AGSK3A 0.699 0.155 4 0.439
ULK2ULK2 0.699 -0.016 2 0.649
RSK2RSK2 0.698 0.004 -3 0.585
BMPR2BMPR2 0.698 -0.073 -2 0.762
ERK7ERK7 0.698 0.157 2 0.497
PKN3PKN3 0.697 -0.008 -3 0.630
BMPR1BBMPR1B 0.697 0.025 1 0.524
P90RSKP90RSK 0.697 0.012 -3 0.595
PIM1PIM1 0.697 0.014 -3 0.592
MLK2MLK2 0.697 0.047 2 0.697
RSK3RSK3 0.697 0.002 -3 0.584
BCKDKBCKDK 0.696 -0.033 -1 0.606
PKCAPKCA 0.696 0.082 2 0.628
PKCDPKCD 0.696 0.046 2 0.663
PKACBPKACB 0.696 0.052 -2 0.574
CAMK1BCAMK1B 0.696 -0.058 -3 0.653
NDR1NDR1 0.695 -0.023 -3 0.631
GRK5GRK5 0.695 -0.083 -3 0.678
CAMK2GCAMK2G 0.695 -0.082 2 0.669
MASTLMASTL 0.695 -0.007 -2 0.711
MPSK1MPSK1 0.694 0.148 1 0.611
MLK3MLK3 0.694 0.009 2 0.631
PKCBPKCB 0.694 0.047 2 0.626
NUAK2NUAK2 0.693 -0.020 -3 0.638
NIKNIK 0.693 -0.029 -3 0.676
NIM1NIM1 0.693 0.080 3 0.708
CAMLCKCAMLCK 0.693 -0.013 -2 0.746
NEK7NEK7 0.693 -0.097 -3 0.658
CAMK2DCAMK2D 0.692 -0.024 -3 0.650
DAPK2DAPK2 0.692 -0.009 -3 0.670
FAM20CFAM20C 0.692 0.018 2 0.526
TGFBR2TGFBR2 0.692 -0.046 -2 0.690
PKN2PKN2 0.692 -0.017 -3 0.644
WNK1WNK1 0.692 -0.057 -2 0.802
DNAPKDNAPK 0.692 0.056 1 0.485
QSKQSK 0.692 0.064 4 0.728
PKCZPKCZ 0.692 0.046 2 0.673
NEK9NEK9 0.692 -0.014 2 0.718
P70S6KBP70S6KB 0.691 -0.021 -3 0.596
MLK1MLK1 0.691 -0.090 2 0.687
LATS1LATS1 0.690 0.018 -3 0.648
AMPKA1AMPKA1 0.690 -0.007 -3 0.658
RIPK3RIPK3 0.690 -0.077 3 0.644
MAPKAPK2MAPKAPK2 0.690 -0.016 -3 0.544
PKACGPKACG 0.689 -0.017 -2 0.631
TGFBR1TGFBR1 0.689 0.008 -2 0.679
PKCGPKCG 0.688 0.023 2 0.627
HUNKHUNK 0.688 -0.085 2 0.670
LATS2LATS2 0.688 -0.035 -5 0.672
MNK2MNK2 0.687 0.027 -2 0.691
AKT2AKT2 0.687 0.024 -3 0.516
PRKXPRKX 0.687 0.023 -3 0.506
SMG1SMG1 0.687 -0.010 1 0.530
PAK1PAK1 0.687 -0.002 -2 0.686
MAPKAPK3MAPKAPK3 0.686 -0.044 -3 0.593
TLK2TLK2 0.686 0.020 1 0.503
IRE1IRE1 0.686 -0.025 1 0.547
SGK3SGK3 0.685 0.030 -3 0.591
PKRPKR 0.685 0.006 1 0.576
VRK2VRK2 0.685 0.103 1 0.634
ULK1ULK1 0.685 -0.094 -3 0.630
AMPKA2AMPKA2 0.685 -0.014 -3 0.621
RSK4RSK4 0.684 -0.008 -3 0.545
GRK4GRK4 0.684 -0.118 -2 0.719
ATMATM 0.683 -0.048 1 0.518
ANKRD3ANKRD3 0.683 -0.103 1 0.576
LKB1LKB1 0.682 0.141 -3 0.707
PHKG1PHKG1 0.682 -0.026 -3 0.636
ALK4ALK4 0.682 -0.036 -2 0.706
CAMK2BCAMK2B 0.682 -0.041 2 0.655
CAMK2ACAMK2A 0.682 -0.041 2 0.667
NEK2NEK2 0.682 0.000 2 0.712
YSK4YSK4 0.682 -0.040 1 0.485
MST3MST3 0.681 0.075 2 0.748
GRK6GRK6 0.681 -0.121 1 0.542
MLK4MLK4 0.681 -0.040 2 0.594
RIPK1RIPK1 0.681 -0.094 1 0.555
CK1ECK1E 0.681 -0.015 -3 0.481
MSK2MSK2 0.681 -0.034 -3 0.575
PAK3PAK3 0.680 -0.027 -2 0.677
ACVR2BACVR2B 0.680 -0.038 -2 0.686
MARK3MARK3 0.680 0.030 4 0.676
MNK1MNK1 0.680 -0.006 -2 0.691
TAO3TAO3 0.680 0.076 1 0.538
GSK3BGSK3B 0.680 0.052 4 0.435
TSSK1TSSK1 0.679 -0.021 -3 0.679
MSK1MSK1 0.679 -0.009 -3 0.574
PINK1PINK1 0.679 0.042 1 0.717
SIKSIK 0.679 0.004 -3 0.565
PRKD3PRKD3 0.678 -0.022 -3 0.562
DLKDLK 0.678 -0.175 1 0.538
MEKK1MEKK1 0.678 0.029 1 0.525
TTBK2TTBK2 0.678 -0.121 2 0.588
DCAMKL1DCAMKL1 0.677 -0.003 -3 0.601
CK1DCK1D 0.677 -0.006 -3 0.442
AURBAURB 0.676 -0.008 -2 0.560
PAK6PAK6 0.676 -0.005 -2 0.610
BRSK1BRSK1 0.676 -0.033 -3 0.600
PKG2PKG2 0.676 -0.012 -2 0.570
ALK2ALK2 0.676 -0.041 -2 0.693
QIKQIK 0.676 -0.040 -3 0.638
NEK5NEK5 0.676 0.034 1 0.550
BRSK2BRSK2 0.675 -0.047 -3 0.623
PLK1PLK1 0.675 -0.089 -2 0.684
PLK4PLK4 0.675 0.008 2 0.497
PIM2PIM2 0.674 -0.013 -3 0.557
AURAAURA 0.674 -0.006 -2 0.541
ACVR2AACVR2A 0.674 -0.062 -2 0.670
CHAK1CHAK1 0.673 -0.090 2 0.700
MEK1MEK1 0.673 -0.112 2 0.699
MELKMELK 0.673 -0.060 -3 0.609
PKCHPKCH 0.673 -0.040 2 0.601
MARK2MARK2 0.672 0.004 4 0.640
TSSK2TSSK2 0.672 -0.074 -5 0.715
PKACAPKACA 0.672 0.008 -2 0.528
DRAK1DRAK1 0.671 -0.069 1 0.542
AKT1AKT1 0.671 0.005 -3 0.533
WNK3WNK3 0.671 -0.233 1 0.531
IRE2IRE2 0.671 -0.071 2 0.601
PERKPERK 0.670 -0.085 -2 0.734
PKCTPKCT 0.670 0.006 2 0.611
BMPR1ABMPR1A 0.670 -0.039 1 0.508
AKT3AKT3 0.670 0.023 -3 0.475
MEKK2MEKK2 0.670 0.004 2 0.661
GCKGCK 0.670 0.077 1 0.523
NUAK1NUAK1 0.669 -0.079 -3 0.575
PLK3PLK3 0.669 -0.096 2 0.636
CAMK4CAMK4 0.669 -0.130 -3 0.611
ZAKZAK 0.668 -0.055 1 0.493
PAK2PAK2 0.668 -0.064 -2 0.665
PDK1PDK1 0.668 0.035 1 0.584
PASKPASK 0.668 -0.052 -3 0.659
MEK5MEK5 0.668 -0.083 2 0.692
CK1G1CK1G1 0.668 -0.038 -3 0.464
NEK11NEK11 0.668 -0.004 1 0.538
CK1A2CK1A2 0.667 -0.029 -3 0.440
BRAFBRAF 0.667 -0.070 -4 0.363
SGK1SGK1 0.666 0.020 -3 0.455
PBKPBK 0.666 0.063 1 0.584
TNIKTNIK 0.666 0.072 3 0.788
MYLK4MYLK4 0.665 -0.067 -2 0.670
GRK2GRK2 0.665 -0.095 -2 0.604
WNK4WNK4 0.665 -0.070 -2 0.811
PKCIPKCI 0.665 -0.018 2 0.643
GAKGAK 0.664 -0.014 1 0.631
CAMKK2CAMKK2 0.664 -0.009 -2 0.664
HPK1HPK1 0.664 0.048 1 0.513
PKCEPKCE 0.664 -0.004 2 0.620
MARK1MARK1 0.664 -0.034 4 0.688
HRIHRI 0.663 -0.133 -2 0.740
IRAK4IRAK4 0.662 -0.066 1 0.532
MAP3K15MAP3K15 0.662 0.061 1 0.500
MAPKAPK5MAPKAPK5 0.662 -0.109 -3 0.552
CK2A2CK2A2 0.662 -0.043 1 0.473
TAO2TAO2 0.662 0.001 2 0.733
KHS1KHS1 0.661 0.080 1 0.497
TLK1TLK1 0.661 -0.117 -2 0.723
MEKK3MEKK3 0.661 -0.140 1 0.525
DCAMKL2DCAMKL2 0.661 -0.045 -3 0.605
CAMK1GCAMK1G 0.661 -0.097 -3 0.558
KHS2KHS2 0.661 0.079 1 0.516
HGKHGK 0.661 0.031 3 0.778
CHK1CHK1 0.660 -0.087 -3 0.614
MEKK6MEKK6 0.660 0.025 1 0.502
PAK5PAK5 0.659 -0.023 -2 0.547
BUB1BUB1 0.659 0.041 -5 0.675
MINKMINK 0.659 0.022 1 0.495
NEK4NEK4 0.659 0.005 1 0.502
CAMKK1CAMKK1 0.658 -0.076 -2 0.663
MST2MST2 0.658 -0.042 1 0.507
PAK4PAK4 0.658 -0.014 -2 0.555
P70S6KP70S6K 0.657 -0.070 -3 0.524
SNRKSNRK 0.657 -0.145 2 0.548
LRRK2LRRK2 0.656 -0.011 2 0.735
NEK1NEK1 0.656 0.034 1 0.520
SMMLCKSMMLCK 0.656 -0.078 -3 0.615
NEK8NEK8 0.655 -0.123 2 0.695
ROCK2ROCK2 0.655 0.005 -3 0.602
SBKSBK 0.655 0.021 -3 0.413
GRK3GRK3 0.655 -0.092 -2 0.570
LOKLOK 0.654 -0.006 -2 0.649
CK2A1CK2A1 0.654 -0.041 1 0.457
VRK1VRK1 0.654 -0.026 2 0.690
PKN1PKN1 0.653 -0.032 -3 0.547
DAPK3DAPK3 0.652 -0.047 -3 0.606
PHKG2PHKG2 0.652 -0.102 -3 0.596
NEK3NEK3 0.652 0.043 1 0.501
YSK1YSK1 0.651 0.020 2 0.709
EEF2KEEF2K 0.651 -0.041 3 0.726
SSTKSSTK 0.651 -0.074 4 0.722
PLK2PLK2 0.651 -0.071 -3 0.593
CK1ACK1A 0.649 -0.035 -3 0.370
MYO3BMYO3B 0.648 0.081 2 0.728
TAK1TAK1 0.648 -0.106 1 0.517
DAPK1DAPK1 0.648 -0.051 -3 0.597
CAMK1DCAMK1D 0.648 -0.085 -3 0.502
OSR1OSR1 0.648 0.000 2 0.692
MRCKBMRCKB 0.647 -0.031 -3 0.547
SLKSLK 0.647 -0.057 -2 0.594
STK33STK33 0.646 -0.082 2 0.520
TTBK1TTBK1 0.646 -0.157 2 0.513
MST1MST1 0.644 -0.081 1 0.492
HASPINHASPIN 0.643 -0.020 -1 0.452
CHK2CHK2 0.642 -0.065 -3 0.474
MRCKAMRCKA 0.641 -0.058 -3 0.556
PDHK3_TYRPDHK3_TYR 0.641 0.243 4 0.808
MEK2MEK2 0.641 -0.095 2 0.674
IRAK1IRAK1 0.641 -0.210 -1 0.496
DMPK1DMPK1 0.640 -0.017 -3 0.562
CRIKCRIK 0.640 -0.014 -3 0.526
BIKEBIKE 0.639 0.013 1 0.584
YANK3YANK3 0.638 -0.031 2 0.348
TAO1TAO1 0.638 0.010 1 0.472
MAP2K4_TYRMAP2K4_TYR 0.637 0.211 -1 0.662
CAMK1ACAMK1A 0.637 -0.077 -3 0.476
ROCK1ROCK1 0.636 -0.029 -3 0.566
PKMYT1_TYRPKMYT1_TYR 0.635 0.238 3 0.778
TTKTTK 0.634 -0.046 -2 0.716
ASK1ASK1 0.634 -0.025 1 0.491
LIMK2_TYRLIMK2_TYR 0.634 0.182 -3 0.699
PDHK4_TYRPDHK4_TYR 0.634 0.107 2 0.756
MAP2K6_TYRMAP2K6_TYR 0.634 0.115 -1 0.661
AAK1AAK1 0.632 0.049 1 0.544
MYO3AMYO3A 0.632 -0.015 1 0.515
PKG1PKG1 0.631 -0.062 -2 0.482
TESK1_TYRTESK1_TYR 0.630 0.097 3 0.813
BMPR2_TYRBMPR2_TYR 0.630 0.034 -1 0.672
ALPHAK3ALPHAK3 0.629 -0.090 -1 0.562
RIPK2RIPK2 0.627 -0.219 1 0.471
PDHK1_TYRPDHK1_TYR 0.626 0.010 -1 0.649
MAP2K7_TYRMAP2K7_TYR 0.625 0.057 2 0.725
EPHA6EPHA6 0.618 -0.020 -1 0.613
EPHB4EPHB4 0.618 -0.003 -1 0.570
RETRET 0.617 -0.029 1 0.529
ABL2ABL2 0.616 0.004 -1 0.570
LIMK1_TYRLIMK1_TYR 0.616 0.006 2 0.725
TXKTXK 0.616 0.011 1 0.522
PINK1_TYRPINK1_TYR 0.615 -0.138 1 0.592
MST1RMST1R 0.613 -0.023 3 0.730
JAK2JAK2 0.613 0.004 1 0.520
FGRFGR 0.613 -0.056 1 0.543
ABL1ABL1 0.613 -0.009 -1 0.567
STLK3STLK3 0.613 -0.129 1 0.457
CSF1RCSF1R 0.612 -0.025 3 0.708
CK1G3CK1G3 0.612 -0.070 -3 0.331
TNNI3K_TYRTNNI3K_TYR 0.611 0.065 1 0.524
LCKLCK 0.611 -0.015 -1 0.591
TYK2TYK2 0.610 -0.064 1 0.514
NEK10_TYRNEK10_TYR 0.610 0.010 1 0.457
JAK3JAK3 0.609 -0.058 1 0.523
BLKBLK 0.609 -0.009 -1 0.589
TNK2TNK2 0.609 -0.009 3 0.678
JAK1JAK1 0.608 0.017 1 0.477
ROS1ROS1 0.608 -0.035 3 0.683
DDR1DDR1 0.607 -0.106 4 0.742
HCKHCK 0.606 -0.061 -1 0.584
FGFR2FGFR2 0.606 -0.045 3 0.724
KDRKDR 0.605 -0.036 3 0.670
YES1YES1 0.605 -0.071 -1 0.586
TYRO3TYRO3 0.605 -0.076 3 0.715
TNK1TNK1 0.605 0.010 3 0.709
EPHA4EPHA4 0.604 -0.064 2 0.654
METMET 0.603 -0.055 3 0.714
KITKIT 0.603 -0.082 3 0.709
YANK2YANK2 0.602 -0.058 2 0.351
ITKITK 0.601 -0.078 -1 0.551
EPHB3EPHB3 0.601 -0.057 -1 0.551
FERFER 0.601 -0.132 1 0.540
FLT1FLT1 0.600 -0.082 -1 0.625
FYNFYN 0.600 -0.056 -1 0.580
FGFR1FGFR1 0.599 -0.044 3 0.684
SRMSSRMS 0.599 -0.116 1 0.512
INSRRINSRR 0.598 -0.118 3 0.662
CK1G2CK1G2 0.598 -0.072 -3 0.400
EPHB1EPHB1 0.598 -0.115 1 0.505
EPHB2EPHB2 0.597 -0.087 -1 0.551
MERTKMERTK 0.597 -0.060 3 0.711
WEE1_TYRWEE1_TYR 0.597 -0.066 -1 0.494
DDR2DDR2 0.596 -0.021 3 0.647
PTK6PTK6 0.595 -0.112 -1 0.499
PDGFRBPDGFRB 0.595 -0.132 3 0.712
PTK2PTK2 0.595 -0.030 -1 0.622
BMXBMX 0.595 -0.074 -1 0.475
TEKTEK 0.595 -0.054 3 0.653
FGFR3FGFR3 0.594 -0.076 3 0.689
FLT3FLT3 0.592 -0.142 3 0.709
EPHA7EPHA7 0.592 -0.073 2 0.652
AXLAXL 0.591 -0.089 3 0.698
NTRK3NTRK3 0.591 -0.074 -1 0.541
SRCSRC 0.590 -0.084 -1 0.573
PDGFRAPDGFRA 0.589 -0.139 3 0.710
MATKMATK 0.589 -0.078 -1 0.507
EPHA1EPHA1 0.589 -0.071 3 0.694
ERBB2ERBB2 0.589 -0.118 1 0.488
PTK2BPTK2B 0.589 -0.060 -1 0.508
SYKSYK 0.588 -0.068 -1 0.584
EPHA3EPHA3 0.588 -0.117 2 0.623
LYNLYN 0.588 -0.103 3 0.624
NTRK1NTRK1 0.588 -0.153 -1 0.581
EGFREGFR 0.587 -0.082 1 0.418
ALKALK 0.587 -0.116 3 0.629
TECTEC 0.586 -0.136 -1 0.474
FRKFRK 0.586 -0.108 -1 0.574
BTKBTK 0.586 -0.193 -1 0.509
EPHA8EPHA8 0.586 -0.084 -1 0.554
ZAP70ZAP70 0.586 -0.011 -1 0.528
INSRINSR 0.585 -0.112 3 0.640
LTKLTK 0.584 -0.136 3 0.660
FLT4FLT4 0.584 -0.148 3 0.667
FGFR4FGFR4 0.584 -0.080 -1 0.545
EPHA5EPHA5 0.583 -0.106 2 0.627
NTRK2NTRK2 0.580 -0.182 3 0.651
CSKCSK 0.580 -0.118 2 0.644
EPHA2EPHA2 0.578 -0.084 -1 0.544
ERBB4ERBB4 0.575 -0.075 1 0.425
MUSKMUSK 0.573 -0.110 1 0.420
IGF1RIGF1R 0.568 -0.135 3 0.584
FESFES 0.560 -0.113 -1 0.465