Motif 290 (n=167)

Position-wise Probabilities

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uniprot genes site source protein function
A0A096LP49 CCDC187 S592 ochoa Coiled-coil domain-containing protein 187 None
A0A0A6YYK5 None S218 ochoa Uncharacterized protein None
A6H8Y1 BDP1 S33 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
A6NDB9 PALM3 S375 ochoa Paralemmin-3 ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}.
A6NNA2 SRRM3 S333 ochoa Serine/arginine repetitive matrix protein 3 May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}.
C9JVG2 ZNF775 S71 ochoa Zinc finger protein 775 None
D6RIA3 C4orf54 S895 ochoa Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) None
H3BNR1 BORCS8-MEF2B S356 ochoa BORCS8-MEF2B readthrough None
O00358 FOXE1 S308 ochoa Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}.
O00358 FOXE1 S329 ochoa Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}.
O14508 SOCS2 S30 ochoa Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2) Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (PubMed:11781573, PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:21980433, PubMed:25505247, PubMed:34857742). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (PubMed:11781573). {ECO:0000269|PubMed:11781573, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:31182716, ECO:0000269|PubMed:34857742, ECO:0000269|PubMed:37816714}.
O14526 FCHO1 S523 ochoa F-BAR domain only protein 1 Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}.
O14641 DVL2 S651 ochoa Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}.
O14901 KLF11 S166 ochoa|psp Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.
O15534 PER1 S27 ochoa Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}.
O43306 ADCY6 S54 ochoa Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17110384, PubMed:17916776). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). {ECO:0000250|UniProtKB:Q01341, ECO:0000250|UniProtKB:Q03343, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:17916776}.
O43521 BCL2L11 S59 psp Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}.
O60336 MAPKBP1 S761 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O60347 TBC1D12 S187 ochoa TBC1 domain family member 12 RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}.
O75061 DNAJC6 S709 ochoa Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}.
O75362 ZNF217 S421 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O94762 RECQL5 S727 ochoa|psp ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5) DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052, PubMed:28100692). Probably unwinds DNA in a 3'-5' direction (Probable) (PubMed:28100692). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Also associates with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA (PubMed:28100692). {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:27502483, ECO:0000269|PubMed:28100692, ECO:0000269|PubMed:28575661, ECO:0000305|PubMed:28100692}.
O94826 TOMM70 S91 ochoa Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). {ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:35025629}.
P10275 AR S426 psp Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
P10588 NR2F6 S145 ochoa Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.
P21359 NF1 S2515 ochoa Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.
P23497 SP100 S191 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P30291 WEE1 S123 psp Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}.
P30291 WEE1 S150 ochoa Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}.
P33240 CSTF2 S524 ochoa Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}.
P36507 MAP2K2 S295 ochoa Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}.
P42684 ABL2 S915 ochoa Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.
P43694 GATA4 S105 psp Transcription factor GATA-4 (GATA-binding factor 4) Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735). {ECO:0000250|UniProtKB:P46152, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15734735, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169, ECO:0000269|PubMed:27984724, ECO:0000269|PubMed:35182466}.
P48634 PRRC2A S1691 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49006 MARCKSL1 S41 ochoa MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}.
P49023 PXN S322 ochoa Paxillin Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
P50461 CSRP3 S95 ochoa Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein) Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.; FUNCTION: [Isoform 2]: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. {ECO:0000269|PubMed:24860983}.
P51798 CLCN7 S48 ochoa H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.
P52735 VAV2 S576 ochoa Guanine nucleotide exchange factor VAV2 (VAV-2) Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.
P53621 COPA S895 ochoa Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.
Q00587 CDC42EP1 S19 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q00587 CDC42EP1 Y331 ochoa Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.
Q02080 MEF2B S339 ochoa Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Q02952 AKAP12 S19 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q02952 AKAP12 S743 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q06587 RING1 S248 ochoa E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Q07687 DLX2 S232 ochoa Homeobox protein DLX-2 Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}.
Q10586 DBP S86 ochoa D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Q12852 MAP3K12 S634 ochoa Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}.
Q13425 SNTB2 S95 ochoa Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Q13501 SQSTM1 S207 ochoa|psp Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}.
Q13627 DYRK1A S555 ochoa Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}.
Q14681 KCTD2 S33 ochoa BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2) None
Q14934 NFATC4 S142 ochoa Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}.
Q15036 SNX17 S446 ochoa Sorting nexin-17 Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}.
Q15464 SHB S211 ochoa SH2 domain-containing adapter protein B Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Q15653 NFKBIB S23 psp NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Q15742 NAB2 S205 ochoa NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q15742 NAB2 S209 ochoa NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q15772 SPEG S2047 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q16584 MAP3K11 S548 ochoa|psp Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Q2TAL5 SMTNL2 S101 ochoa Smoothelin-like protein 2 None
Q4KMQ1 TPRN S362 ochoa Taperin Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}.
Q53F19 NCBP3 S25 ochoa Nuclear cap-binding protein subunit 3 (Protein ELG) Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.
Q5JPI9 EEF1AKMT2 S21 ochoa EEF1A lysine methyltransferase 2 (EC 2.1.1.-) (Methyltransferase-like protein 10) (Protein-lysine N-methyltransferase METTL10) [Isoform 2]: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183, ECO:0000269|PubMed:38199565}.
Q5SV97 PERM1 S206 ochoa PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}.
Q5SV97 PERM1 S242 ochoa PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}.
Q5T8A7 PPP1R26 S1132 ochoa Protein phosphatase 1 regulatory subunit 26 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. {ECO:0000269|PubMed:16053918, ECO:0000269|PubMed:19389623}.
Q5TC12 ATPAF1 S40 ochoa ATP synthase mitochondrial F1 complex assembly factor 1 (ATP11 homolog) Has a complex stabilizing activity in the assembly of the mitochondrial F1-F0 complex. {ECO:0000250|UniProtKB:Q811I0}.
Q5U651 RASIP1 S197 ochoa Ras-interacting protein 1 (Rain) Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.
Q5UE93 PIK3R6 S358 ochoa|psp Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.
Q63HR2 TNS2 S825 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q63ZY3 KANK2 S171 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q63ZY6 NSUN5P2 S143 ochoa Putative methyltransferase NSUN5C (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5C) (Williams-Beuren syndrome chromosomal region 20C protein) May have S-adenosyl-L-methionine-dependent methyl-transferase activity. {ECO:0000305}.
Q6F5E8 CARMIL2 S1321 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6PK04 CCDC137 S19 ochoa Coiled-coil domain-containing protein 137 None
Q6ZVH7 ESPNL S786 ochoa Espin-like protein Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.
Q765P7 MTSS2 S428 ochoa Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.
Q7L2J0 MEPCE S69 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q7L311 ARMCX2 S213 ochoa Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}.
Q7Z2K8 GPRIN1 S507 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q86TB9 PATL1 S278 ochoa Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}.
Q86UU0 BCL9L S750 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86WR7 PROSER2 S312 ochoa Proline and serine-rich protein 2 None
Q86XL3 ANKLE2 S919 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8IUW3 SPATA2L S252 ochoa Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) None
Q8IV31 TMEM139 S155 ochoa Transmembrane protein 139 May be involved in cellular trafficking of proteins such as SLC4A1. {ECO:0000305|PubMed:26049106}.
Q8IWE5 PLEKHM2 S496 ochoa Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.
Q8IX07 ZFPM1 S128 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IYA7 MKX S36 ochoa Homeobox protein Mohawk May act as a morphogenetic regulator of cell adhesion. {ECO:0000250}.
Q8IZD0 SAMD14 S77 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8N3D4 EHBP1L1 S1017 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N8E2 ZNF513 S515 ochoa Zinc finger protein 513 Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}.
Q8NDT2 RBM15B S267 ochoa Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
Q8NHW3 MAFA S65 psp Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) Transcription factor that activates insulin gene expression (PubMed:12011435, PubMed:15993959). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:23148532, ECO:0000269|PubMed:29339498}.
Q8NHW3 MAFA S336 psp Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) Transcription factor that activates insulin gene expression (PubMed:12011435, PubMed:15993959). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:23148532, ECO:0000269|PubMed:29339498}.
Q8TAP9 MPLKIP S40 ochoa M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
Q8TBC3 SHKBP1 S649 ochoa SH3KBP1-binding protein 1 (SETA-binding protein 1) Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.
Q8TD19 NEK9 S29 ochoa|psp Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TD19 NEK9 S793 ochoa Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}.
Q8TDN4 CABLES1 S109 ochoa CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Q8TDN4 CABLES1 S168 ochoa CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
Q8WW22 DNAJA4 S84 ochoa DnaJ homolog subfamily A member 4 None
Q8WWA1 TMEM40 S99 ochoa Transmembrane protein 40 None
Q8WXE0 CASKIN2 S725 ochoa Caskin-2 (CASK-interacting protein 2) None
Q8WXF1 PSPC1 S409 ochoa Paraspeckle component 1 (Paraspeckle protein 1) RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.
Q92733 PRCC S114 ochoa Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}.
Q92908 GATA6 S268 ochoa Transcription factor GATA-6 (GATA-binding factor 6) Transcriptional activator (PubMed:19666519, PubMed:22750565, PubMed:22824924, PubMed:27756709). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:33082341, ECO:0000269|PubMed:9315713}.
Q969W3 VCF1 S21 ochoa Protein VCF1 (VCP nuclear cofactor family member 1) None
Q96BV0 ZNF775 S71 ochoa Zinc finger protein 775 May be involved in transcriptional regulation.
Q96CX2 KCTD12 S176 ochoa BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q96FS4 SIPA1 S67 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q96G74 OTUD5 S64 ochoa OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:33523931}.
Q96H86 ZNF764 S136 ochoa Zinc finger protein 764 Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR (PubMed:28139699). Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes (PubMed:28139699). {ECO:0000269|PubMed:28139699}.
Q96I51 RCC1L S272 ochoa RCC1-like G exchanging factor-like protein (RCC1-like protein) (Williams-Beuren syndrome chromosomal region 16 protein) Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:28746876}.; FUNCTION: [Isoform 1]: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the large ribosome subunit. {ECO:0000269|PubMed:32735630}.; FUNCTION: [Isoform 2]: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the small ribosome subunit. {ECO:0000269|PubMed:32735630}.
Q96IF1 AJUBA S175 ochoa|psp LIM domain-containing protein ajuba Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}.
Q96JH8 RADIL S393 ochoa Ras-associating and dilute domain-containing protein Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}.
Q96P11 NSUN5 S327 ochoa 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}.
Q96PE2 ARHGEF17 S507 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96PN7 TRERF1 S54 ochoa Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q96PN7 TRERF1 S491 ochoa Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q96T37 RBM15 S294 ochoa|psp RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q9BQQ3 GORASP1 S274 psp Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.
Q9BT81 SOX7 S166 ochoa Transcription factor SOX-7 Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}.
Q9BUG6 ZSCAN5A S335 ochoa Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) May be involved in transcriptional regulation.
Q9BX95 SGPP1 S101 ochoa Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:11756451, PubMed:12815058, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:18583713, PubMed:20798685). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9JI99, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12815058, ECO:0000269|PubMed:16782891, ECO:0000269|PubMed:18583713, ECO:0000269|PubMed:20798685}.
Q9BXB5 OSBPL10 S57 ochoa Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}.
Q9BYB0 SHANK3 S986 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYB0 SHANK3 S1529 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYB0 SHANK3 S1577 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYX2 TBC1D2 S240 ochoa TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}.
Q9C0B0 UNK S631 psp RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0C2 TNKS1BP1 S1029 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S1503 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C9 UBE2O S115 ochoa (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}.
Q9C0K0 BCL11B S497 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H008 LHPP S191 ochoa Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (hLHPP) (EC 3.1.3.-) (EC 3.6.1.1) Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.
Q9H0L4 CSTF2T S563 ochoa Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64) May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}.
Q9H3T3 SEMA6B S822 ochoa Semaphorin-6B (Semaphorin-Z) (Sema Z) Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}.
Q9H6K5 PRR36 S173 ochoa Proline-rich protein 36 None
Q9H773 DCTPP1 S26 ochoa dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.
Q9H7S9 ZNF703 S252 ochoa Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.
Q9H7Z6 KAT8 S42 ochoa Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}.
Q9H7Z7 PTGES2 S46 ochoa Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}.
Q9HBL0 TNS1 S1393 psp Tensin-1 (EC 3.1.3.-) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}.
Q9HC52 CBX8 S332 ochoa Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.
Q9HCE5 METTL14 S399 ochoa|psp N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14) (hMETTL14) The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27281194, PubMed:27373337, PubMed:29348140). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q3UIK4, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:29348140}.
Q9HCM7 FBRSL1 S728 ochoa Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) None
Q9NP08 HMX1 S129 ochoa Homeobox protein HMX1 (Homeobox protein H6) DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269|PubMed:10206974}.
Q9NY59 SMPD3 S238 ochoa Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Q9P0U4 CXXC1 S138 ochoa CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.
Q9P270 SLAIN2 S48 ochoa|psp SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UBB5 MBD2 S44 ochoa Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.
Q9UIF9 BAZ2A S135 ochoa Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}.
Q9UIU6 SIX4 S44 ochoa Homeobox protein SIX4 (Sine oculis homeobox homolog 4) Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}.
Q9UK39 NOCT S33 ochoa Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}.
Q9ULD9 ZNF608 S421 ochoa Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}.
Q9UPE1 SRPK3 S335 ochoa SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). {ECO:0000250|UniProtKB:Q9Z0G2}.
Q9UQF2 MAPK8IP1 S341 psp C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.
Q9Y261 FOXA2 S107 psp Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.
Q9Y2H5 PLEKHA6 S251 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y3Q4 HCN4 S1026 ochoa Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353). Exhibits higher selectivity for K(+) over Na(+) ions (PubMed:10228147). Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (Probable) (PubMed:10228147, PubMed:16407510, PubMed:19165230). Contributes to the native pacemaker currents in neurons (Ih) (Probable). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:Q9JKA7, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353, ECO:0000305|PubMed:10430953}.
Q9Y3Q8 TSC22D4 S62 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y4B5 MTCL1 S1106 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y566 SHANK1 S413 ochoa SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Q9Y5B6 PAXBP1 S62 ochoa PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}.
P08151 GLI1 S602 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
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reactome_id name p -log10_p
R-HSA-9823730 Formation of definitive endoderm 4.373816e-07 6.359
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 4.794704e-06 5.319
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 3.190522e-05 4.496
R-HSA-9733709 Cardiogenesis 9.745830e-04 3.011
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 2.070689e-03 2.684
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.732460e-03 2.761
R-HSA-9909396 Circadian clock 1.366481e-03 2.864
R-HSA-9607240 FLT3 Signaling 2.072067e-03 2.684
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 2.923191e-03 2.534
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 3.628586e-03 2.440
R-HSA-9758920 Formation of lateral plate mesoderm 3.628586e-03 2.440
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 1.179177e-02 1.928
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.273030e-02 1.895
R-HSA-9758941 Gastrulation 1.088188e-02 1.963
R-HSA-9796292 Formation of axial mesoderm 1.536189e-02 1.814
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5.348384e-02 1.272
R-HSA-111446 Activation of BIM and translocation to mitochondria 5.348384e-02 1.272
R-HSA-1296061 HCN channels 6.383425e-02 1.195
R-HSA-9652169 Signaling by MAP2K mutants 6.383425e-02 1.195
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 9.421501e-02 1.026
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 9.421501e-02 1.026
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 1.041225e-01 0.982
R-HSA-201688 WNT mediated activation of DVL 1.236152e-01 0.908
R-HSA-112411 MAPK1 (ERK2) activation 1.236152e-01 0.908
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.520664e-01 0.818
R-HSA-170660 Adenylate cyclase activating pathway 1.705217e-01 0.768
R-HSA-170670 Adenylate cyclase inhibitory pathway 1.885775e-01 0.725
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 2.062424e-01 0.686
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 2.404332e-01 0.619
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.919074e-01 0.717
R-HSA-383280 Nuclear Receptor transcription pathway 2.440698e-01 0.612
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 4.104475e-01 0.387
R-HSA-5674135 MAP2K and MAPK activation 4.169116e-01 0.380
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.195589e-01 0.922
R-HSA-9649948 Signaling downstream of RAS mutants 1.195589e-01 0.922
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.195589e-01 0.922
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.705217e-01 0.768
R-HSA-5610780 Degradation of GLI1 by the proteasome 4.169116e-01 0.380
R-HSA-77595 Processing of Intronless Pre-mRNAs 2.278286e-02 1.642
R-HSA-5099900 WNT5A-dependent internalization of FZD4 1.974583e-01 0.705
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 2.278286e-02 1.642
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1.613445e-01 0.792
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 2.569754e-01 0.590
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 2.651116e-01 0.577
R-HSA-6802957 Oncogenic MAPK signaling 2.001544e-02 1.699
R-HSA-9656223 Signaling by RAF1 mutants 4.169116e-01 0.380
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.270913e-01 0.485
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.770425e-01 0.424
R-HSA-9664420 Killing mechanisms 1.974583e-01 0.705
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.974583e-01 0.705
R-HSA-6802949 Signaling by RAS mutants 1.195589e-01 0.922
R-HSA-72187 mRNA 3'-end processing 1.416402e-01 0.849
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.838708e-01 0.416
R-HSA-991365 Activation of GABAB receptors 4.233052e-01 0.373
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 2.651116e-01 0.577
R-HSA-74158 RNA Polymerase III Transcription 3.770425e-01 0.424
R-HSA-6807878 COPI-mediated anterograde transport 3.289359e-01 0.483
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.569754e-01 0.590
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.044829e-01 0.516
R-HSA-427413 NoRC negatively regulates rRNA expression 2.158394e-01 0.666
R-HSA-4641258 Degradation of DVL 3.838708e-01 0.416
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.104475e-01 0.387
R-HSA-8856828 Clathrin-mediated endocytosis 2.609594e-01 0.583
R-HSA-977444 GABA B receptor activation 4.233052e-01 0.373
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 4.301965e-02 1.366
R-HSA-69478 G2/M DNA replication checkpoint 9.421501e-02 1.026
R-HSA-9927354 Co-stimulation by ICOS 1.139221e-01 0.943
R-HSA-209560 NF-kB is activated and signals survival 1.520664e-01 0.818
R-HSA-164378 PKA activation in glucagon signalling 2.235249e-01 0.651
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 2.731592e-01 0.564
R-HSA-73728 RNA Polymerase I Promoter Opening 3.044829e-01 0.516
R-HSA-73856 RNA Polymerase II Transcription Termination 1.761641e-01 0.754
R-HSA-163359 Glucagon signaling in metabolic regulation 3.561031e-01 0.448
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.701391e-01 0.432
R-HSA-193639 p75NTR signals via NF-kB 1.885775e-01 0.725
R-HSA-9734767 Developmental Cell Lineages 9.366670e-02 1.028
R-HSA-209543 p75NTR recruits signalling complexes 1.613445e-01 0.792
R-HSA-4608870 Asymmetric localization of PCP proteins 4.420707e-01 0.355
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1.139221e-01 0.943
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 4.362425e-02 1.360
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.705217e-01 0.768
R-HSA-429914 Deadenylation-dependent mRNA decay 1.683734e-01 0.774
R-HSA-5632684 Hedgehog 'on' state 2.158394e-01 0.666
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3.344639e-01 0.476
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.038331e-01 0.691
R-HSA-114604 GPVI-mediated activation cascade 8.181655e-02 1.087
R-HSA-2424491 DAP12 signaling 3.270913e-01 0.485
R-HSA-5610787 Hedgehog 'off' state 1.243022e-01 0.906
R-HSA-5626978 TNFR1-mediated ceramide production 6.383425e-02 1.195
R-HSA-71737 Pyrophosphate hydrolysis 7.407210e-02 1.130
R-HSA-5674499 Negative feedback regulation of MAPK pathway 8.419862e-02 1.075
R-HSA-9690406 Transcriptional regulation of testis differentiation 2.062424e-01 0.686
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 2.521698e-01 0.598
R-HSA-9932298 Degradation of CRY and PER proteins 4.169116e-01 0.380
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 4.542425e-01 0.343
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.702800e-01 0.769
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 4.172751e-01 0.380
R-HSA-9664873 Pexophagy 1.332029e-01 0.875
R-HSA-170968 Frs2-mediated activation 1.705217e-01 0.768
R-HSA-68875 Mitotic Prophase 4.337284e-01 0.363
R-HSA-5358351 Signaling by Hedgehog 2.433772e-01 0.614
R-HSA-194138 Signaling by VEGF 2.004502e-01 0.698
R-HSA-205043 NRIF signals cell death from the nucleus 1.795990e-01 0.746
R-HSA-193648 NRAGE signals death through JNK 3.424896e-02 1.465
R-HSA-201681 TCF dependent signaling in response to WNT 3.831030e-01 0.417
R-HSA-445144 Signal transduction by L1 3.138466e-02 1.503
R-HSA-8953750 Transcriptional Regulation by E2F6 3.973048e-01 0.401
R-HSA-9031628 NGF-stimulated transcription 1.268202e-01 0.897
R-HSA-9706369 Negative regulation of FLT3 2.081228e-02 1.682
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 5.447696e-02 1.264
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.885775e-01 0.725
R-HSA-163615 PKA activation 2.235249e-01 0.651
R-HSA-112409 RAF-independent MAPK1/3 activation 2.651116e-01 0.577
R-HSA-429947 Deadenylation of mRNA 2.811192e-01 0.551
R-HSA-933542 TRAF6 mediated NF-kB activation 2.811192e-01 0.551
R-HSA-389357 CD28 dependent PI3K/Akt signaling 3.044829e-01 0.516
R-HSA-169893 Prolonged ERK activation events 1.974583e-01 0.705
R-HSA-6794361 Neurexins and neuroligins 1.416402e-01 0.849
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 2.198563e-01 0.658
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 8.419862e-02 1.075
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.694347e-02 1.570
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.885775e-01 0.725
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 6.920868e-02 1.160
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 7.860140e-02 1.105
R-HSA-193704 p75 NTR receptor-mediated signalling 3.402352e-02 1.468
R-HSA-5218920 VEGFR2 mediated vascular permeability 4.104475e-01 0.387
R-HSA-2172127 DAP12 interactions 4.358840e-01 0.361
R-HSA-5205647 Mitophagy 7.542750e-02 1.122
R-HSA-6793080 rRNA modification in the mitochondrion 1.705217e-01 0.768
R-HSA-210745 Regulation of gene expression in beta cells 5.732455e-02 1.242
R-HSA-5578768 Physiological factors 1.795990e-01 0.746
R-HSA-5673000 RAF activation 7.542750e-02 1.122
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 2.967801e-01 0.528
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 4.233052e-01 0.373
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 4.420707e-01 0.355
R-HSA-9659379 Sensory processing of sound 2.481187e-01 0.605
R-HSA-9932444 ATP-dependent chromatin remodelers 2.889925e-01 0.539
R-HSA-9932451 SWI/SNF chromatin remodelers 2.889925e-01 0.539
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 1.041225e-01 0.982
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.332029e-01 0.875
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... 2.062424e-01 0.686
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 8.507168e-02 1.070
R-HSA-392517 Rap1 signalling 2.320254e-01 0.634
R-HSA-111931 PKA-mediated phosphorylation of CREB 2.487496e-01 0.604
R-HSA-525793 Myogenesis 2.967801e-01 0.528
R-HSA-8863795 Downregulation of ERBB2 signaling 3.270913e-01 0.485
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 2.038331e-01 0.691
R-HSA-8868766 rRNA processing in the mitochondrion 4.039121e-01 0.394
R-HSA-9663891 Selective autophagy 2.886496e-01 0.540
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.088920e-01 0.680
R-HSA-8943724 Regulation of PTEN gene transcription 1.722613e-01 0.764
R-HSA-397795 G-protein beta:gamma signalling 3.489689e-01 0.457
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 4.420707e-01 0.355
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 3.607261e-01 0.443
R-HSA-9937008 Mitochondrial mRNA modification 2.731592e-01 0.564
R-HSA-1482801 Acyl chain remodelling of PS 2.889925e-01 0.539
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.568062e-01 0.805
R-HSA-187687 Signalling to ERKs 3.701391e-01 0.432
R-HSA-432720 Lysosome Vesicle Biogenesis 3.770425e-01 0.424
R-HSA-6794362 Protein-protein interactions at synapses 2.724418e-01 0.565
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 4.542425e-01 0.343
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.795990e-01 0.746
R-HSA-8876725 Protein methylation 1.885775e-01 0.725
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 7.542750e-02 1.122
R-HSA-114452 Activation of BH3-only proteins 3.270913e-01 0.485
R-HSA-5683826 Surfactant metabolism 4.358840e-01 0.361
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 2.935753e-01 0.532
R-HSA-446353 Cell-extracellular matrix interactions 1.885775e-01 0.725
R-HSA-9845614 Sphingolipid catabolism 2.967801e-01 0.528
R-HSA-73887 Death Receptor Signaling 4.241077e-02 1.373
R-HSA-212165 Epigenetic regulation of gene expression 3.258723e-01 0.487
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 2.694347e-02 1.570
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.235249e-01 0.651
R-HSA-180292 GAB1 signalosome 2.235249e-01 0.651
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 1.800808e-01 0.745
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.489689e-01 0.457
R-HSA-166520 Signaling by NTRKs 2.757356e-01 0.560
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3.121017e-01 0.506
R-HSA-1266695 Interleukin-7 signaling 4.625375e-02 1.335
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 4.894006e-02 1.310
R-HSA-186712 Regulation of beta-cell development 1.683734e-01 0.774
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 3.344639e-01 0.476
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1.101386e-01 0.958
R-HSA-2559580 Oxidative Stress Induced Senescence 3.528258e-01 0.452
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 3.561031e-01 0.448
R-HSA-9008059 Interleukin-37 signaling 6.022294e-02 1.220
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.651116e-01 0.577
R-HSA-982772 Growth hormone receptor signaling 2.731592e-01 0.564
R-HSA-9764560 Regulation of CDH1 Gene Transcription 2.118295e-01 0.674
R-HSA-5689896 Ovarian tumor domain proteases 3.838708e-01 0.416
R-HSA-8854214 TBC/RABGAPs 4.296291e-01 0.367
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 6.423094e-02 1.192
R-HSA-156711 Polo-like kinase mediated events 2.235249e-01 0.651
R-HSA-416482 G alpha (12/13) signalling events 2.440698e-01 0.612
R-HSA-400508 Incretin synthesis, secretion, and inactivation 4.233052e-01 0.373
R-HSA-8941326 RUNX2 regulates bone development 3.770425e-01 0.424
R-HSA-5675221 Negative regulation of MAPK pathway 4.169116e-01 0.380
R-HSA-373760 L1CAM interactions 4.187065e-01 0.378
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 2.198563e-01 0.658
R-HSA-9020702 Interleukin-1 signaling 3.488631e-01 0.457
R-HSA-5210891 Uptake and function of anthrax toxins 2.149310e-01 0.668
R-HSA-69202 Cyclin E associated events during G1/S transition 2.118295e-01 0.674
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 4.362425e-02 1.360
R-HSA-8863678 Neurodegenerative Diseases 4.362425e-02 1.360
R-HSA-446652 Interleukin-1 family signaling 1.189660e-01 0.925
R-HSA-111933 Calmodulin induced events 3.770425e-01 0.424
R-HSA-8878159 Transcriptional regulation by RUNX3 3.329354e-01 0.478
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 5.168164e-02 1.287
R-HSA-111997 CaM pathway 3.770425e-01 0.424
R-HSA-8853659 RET signaling 3.770425e-01 0.424
R-HSA-1538133 G0 and Early G1 3.417561e-01 0.466
R-HSA-111996 Ca-dependent events 4.233052e-01 0.373
R-HSA-1489509 DAG and IP3 signaling 4.420707e-01 0.355
R-HSA-9614085 FOXO-mediated transcription 3.409140e-01 0.467
R-HSA-1483255 PI Metabolism 3.528258e-01 0.452
R-HSA-2028269 Signaling by Hippo 2.149310e-01 0.668
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 2.562227e-01 0.591
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 3.906246e-01 0.408
R-HSA-1592230 Mitochondrial biogenesis 4.224810e-01 0.374
R-HSA-9645723 Diseases of programmed cell death 2.886496e-01 0.540
R-HSA-8986944 Transcriptional Regulation by MECP2 3.007805e-01 0.522
R-HSA-9759194 Nuclear events mediated by NFE2L2 4.374517e-01 0.359
R-HSA-381038 XBP1(S) activates chaperone genes 2.805490e-01 0.552
R-HSA-453279 Mitotic G1 phase and G1/S transition 2.698136e-01 0.569
R-HSA-381070 IRE1alpha activates chaperones 3.048171e-01 0.516
R-HSA-69206 G1/S Transition 4.558670e-01 0.341
R-HSA-9634597 GPER1 signaling 4.602290e-01 0.337
R-HSA-389356 Co-stimulation by CD28 4.602290e-01 0.337
R-HSA-69278 Cell Cycle, Mitotic 4.672492e-01 0.330
R-HSA-5658442 Regulation of RAS by GAPs 4.720068e-01 0.326
R-HSA-9748787 Azathioprine ADME 4.720068e-01 0.326
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 4.720068e-01 0.326
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 4.777995e-01 0.321
R-HSA-1169091 Activation of NF-kappaB in B cells 4.777995e-01 0.321
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 4.835290e-01 0.316
R-HSA-5339562 Uptake and actions of bacterial toxins 4.835290e-01 0.316
R-HSA-445355 Smooth Muscle Contraction 4.891960e-01 0.311
R-HSA-432722 Golgi Associated Vesicle Biogenesis 4.891960e-01 0.311
R-HSA-418597 G alpha (z) signalling events 5.003452e-01 0.301
R-HSA-109606 Intrinsic Pathway for Apoptosis 5.058287e-01 0.296
R-HSA-177929 Signaling by EGFR 5.058287e-01 0.296
R-HSA-75893 TNF signaling 5.058287e-01 0.296
R-HSA-8878171 Transcriptional regulation by RUNX1 5.086732e-01 0.294
R-HSA-2980766 Nuclear Envelope Breakdown 5.112524e-01 0.291
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.112524e-01 0.291
R-HSA-6807070 PTEN Regulation 5.123833e-01 0.290
R-HSA-381119 Unfolded Protein Response (UPR) 5.123833e-01 0.290
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 5.166168e-01 0.287
R-HSA-1632852 Macroautophagy 5.191749e-01 0.285
R-HSA-74160 Gene expression (Transcription) 5.225623e-01 0.282
R-HSA-977443 GABA receptor activation 5.271708e-01 0.278
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 5.271708e-01 0.278
R-HSA-1227986 Signaling by ERBB2 5.271708e-01 0.278
R-HSA-445717 Aquaporin-mediated transport 5.323615e-01 0.274
R-HSA-112043 PLC beta mediated events 5.323615e-01 0.274
R-HSA-6784531 tRNA processing in the nucleus 5.374955e-01 0.270
R-HSA-1268020 Mitochondrial protein import 5.374955e-01 0.270
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.392210e-01 0.268
R-HSA-199977 ER to Golgi Anterograde Transport 5.424476e-01 0.266
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.425735e-01 0.266
R-HSA-8848021 Signaling by PTK6 5.425735e-01 0.266
R-HSA-69242 S Phase 5.457084e-01 0.263
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 5.485429e-01 0.261
R-HSA-9856651 MITF-M-dependent gene expression 5.521814e-01 0.258
R-HSA-1234174 Cellular response to hypoxia 5.525638e-01 0.258
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.553937e-01 0.255
R-HSA-112040 G-protein mediated events 5.623371e-01 0.250
R-HSA-9006925 Intracellular signaling by second messengers 5.646062e-01 0.248
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.671439e-01 0.246
R-HSA-9612973 Autophagy 5.712109e-01 0.243
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.766004e-01 0.239
R-HSA-204005 COPII-mediated vesicle transport 5.766004e-01 0.239
R-HSA-9840310 Glycosphingolipid catabolism 5.766004e-01 0.239
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 5.766004e-01 0.239
R-HSA-877300 Interferon gamma signaling 5.805052e-01 0.236
R-HSA-5688426 Deubiquitination 5.838421e-01 0.234
R-HSA-199992 trans-Golgi Network Vesicle Budding 5.858516e-01 0.232
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 5.858516e-01 0.232
R-HSA-69473 G2/M DNA damage checkpoint 5.949017e-01 0.226
R-HSA-3000171 Non-integrin membrane-ECM interactions 5.993527e-01 0.222
R-HSA-73854 RNA Polymerase I Promoter Clearance 6.037551e-01 0.219
R-HSA-4086400 PCP/CE pathway 6.124161e-01 0.213
R-HSA-73864 RNA Polymerase I Transcription 6.124161e-01 0.213
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 6.208888e-01 0.207
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 6.208888e-01 0.207
R-HSA-5689880 Ub-specific processing proteases 6.247589e-01 0.204
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 6.247589e-01 0.204
R-HSA-9764265 Regulation of CDH1 Expression and Function 6.247589e-01 0.204
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 6.372857e-01 0.196
R-HSA-446728 Cell junction organization 6.380535e-01 0.195
R-HSA-2559583 Cellular Senescence 6.441487e-01 0.191
R-HSA-9658195 Leishmania infection 6.447520e-01 0.191
R-HSA-9824443 Parasitic Infection Pathways 6.447520e-01 0.191
R-HSA-69275 G2/M Transition 6.601358e-01 0.180
R-HSA-5673001 RAF/MAP kinase cascade 6.621879e-01 0.179
R-HSA-1280215 Cytokine Signaling in Immune system 6.640421e-01 0.178
R-HSA-453274 Mitotic G2-G2/M phases 6.653362e-01 0.177
R-HSA-1257604 PIP3 activates AKT signaling 6.748565e-01 0.171
R-HSA-1483257 Phospholipid metabolism 6.748565e-01 0.171
R-HSA-2682334 EPH-Ephrin signaling 6.752577e-01 0.171
R-HSA-5684996 MAPK1/MAPK3 signaling 6.769339e-01 0.169
R-HSA-1266738 Developmental Biology 6.796344e-01 0.168
R-HSA-195721 Signaling by WNT 6.810595e-01 0.167
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 6.823638e-01 0.166
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 6.855023e-01 0.164
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 6.927339e-01 0.159
R-HSA-1296071 Potassium Channels 6.927339e-01 0.159
R-HSA-1640170 Cell Cycle 6.938955e-01 0.159
R-HSA-428157 Sphingolipid metabolism 6.975965e-01 0.156
R-HSA-422356 Regulation of insulin secretion 6.994596e-01 0.155
R-HSA-975871 MyD88 cascade initiated on plasma membrane 6.994596e-01 0.155
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 6.994596e-01 0.155
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 6.994596e-01 0.155
R-HSA-948021 Transport to the Golgi and subsequent modification 6.999690e-01 0.155
R-HSA-3214847 HATs acetylate histones 7.027673e-01 0.153
R-HSA-1500931 Cell-Cell communication 7.164468e-01 0.145
R-HSA-449147 Signaling by Interleukins 7.172998e-01 0.144
R-HSA-111885 Opioid Signalling 7.187708e-01 0.143
R-HSA-9860931 Response of endothelial cells to shear stress 7.187708e-01 0.143
R-HSA-5619507 Activation of HOX genes during differentiation 7.218672e-01 0.142
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.218672e-01 0.142
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 7.249297e-01 0.140
R-HSA-397014 Muscle contraction 7.250636e-01 0.140
R-HSA-9730414 MITF-M-regulated melanocyte development 7.272552e-01 0.138
R-HSA-9692914 SARS-CoV-1-host interactions 7.279586e-01 0.138
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 7.309543e-01 0.136
R-HSA-9700206 Signaling by ALK in cancer 7.309543e-01 0.136
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 7.339173e-01 0.134
R-HSA-2672351 Stimuli-sensing channels 7.339173e-01 0.134
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 7.368478e-01 0.133
R-HSA-975155 MyD88 dependent cascade initiated on endosome 7.368478e-01 0.133
R-HSA-418990 Adherens junctions interactions 7.379937e-01 0.132
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 7.397462e-01 0.131
R-HSA-166166 MyD88-independent TLR4 cascade 7.397462e-01 0.131
R-HSA-8951664 Neddylation 7.442634e-01 0.128
R-HSA-2871796 FCERI mediated MAPK activation 7.454481e-01 0.128
R-HSA-199991 Membrane Trafficking 7.478705e-01 0.126
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 7.482523e-01 0.126
R-HSA-9855142 Cellular responses to mechanical stimuli 7.510258e-01 0.124
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 7.564820e-01 0.121
R-HSA-2871809 FCERI mediated Ca+2 mobilization 7.591653e-01 0.120
R-HSA-9007101 Rab regulation of trafficking 7.644441e-01 0.117
R-HSA-2980736 Peptide hormone metabolism 7.644441e-01 0.117
R-HSA-2219528 PI3K/AKT Signaling in Cancer 7.670402e-01 0.115
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 7.696078e-01 0.114
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 7.696078e-01 0.114
R-HSA-8878166 Transcriptional regulation by RUNX2 7.696078e-01 0.114
R-HSA-5683057 MAPK family signaling cascades 7.702022e-01 0.113
R-HSA-162582 Signal Transduction 7.769379e-01 0.110
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 7.771430e-01 0.109
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 7.771430e-01 0.109
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.795999e-01 0.108
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.795999e-01 0.108
R-HSA-1660662 Glycosphingolipid metabolism 7.795999e-01 0.108
R-HSA-109582 Hemostasis 7.860290e-01 0.105
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.868101e-01 0.104
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.868101e-01 0.104
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.868101e-01 0.104
R-HSA-112316 Neuronal System 7.881014e-01 0.103
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 7.891610e-01 0.103
R-HSA-73857 RNA Polymerase II Transcription 7.898915e-01 0.102
R-HSA-69481 G2/M Checkpoints 7.914861e-01 0.102
R-HSA-9675108 Nervous system development 7.956107e-01 0.099
R-HSA-4839726 Chromatin organization 7.968291e-01 0.099
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.983096e-01 0.098
R-HSA-421270 Cell-cell junction organization 8.001938e-01 0.097
R-HSA-5576891 Cardiac conduction 8.027348e-01 0.095
R-HSA-8856688 Golgi-to-ER retrograde transport 8.049110e-01 0.094
R-HSA-2262752 Cellular responses to stress 8.121578e-01 0.090
R-HSA-3858494 Beta-catenin independent WNT signaling 8.154393e-01 0.089
R-HSA-163685 Integration of energy metabolism 8.154393e-01 0.089
R-HSA-9018519 Estrogen-dependent gene expression 8.154393e-01 0.089
R-HSA-68886 M Phase 8.219412e-01 0.085
R-HSA-9664407 Parasite infection 8.234535e-01 0.084
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.234535e-01 0.084
R-HSA-9664417 Leishmania phagocytosis 8.234535e-01 0.084
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.254024e-01 0.083
R-HSA-9711123 Cellular response to chemical stress 8.268613e-01 0.083
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 8.292362e-01 0.081
R-HSA-212436 Generic Transcription Pathway 8.310096e-01 0.080
R-HSA-8953897 Cellular responses to stimuli 8.316576e-01 0.080
R-HSA-8953854 Metabolism of RNA 8.352798e-01 0.078
R-HSA-76002 Platelet activation, signaling and aggregation 8.354861e-01 0.078
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 8.402426e-01 0.076
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.463850e-01 0.072
R-HSA-2142753 Arachidonate metabolism 8.471853e-01 0.072
R-HSA-9609507 Protein localization 8.488736e-01 0.071
R-HSA-9610379 HCMV Late Events 8.554433e-01 0.068
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 8.570408e-01 0.067
R-HSA-109581 Apoptosis 8.632573e-01 0.064
R-HSA-422475 Axon guidance 8.720363e-01 0.059
R-HSA-72306 tRNA processing 8.762790e-01 0.057
R-HSA-418555 G alpha (s) signalling events 8.776475e-01 0.057
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.803395e-01 0.055
R-HSA-9664433 Leishmania parasite growth and survival 8.803395e-01 0.055
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 8.816633e-01 0.055
R-HSA-9678108 SARS-CoV-1 Infection 8.829726e-01 0.054
R-HSA-1852241 Organelle biogenesis and maintenance 8.897376e-01 0.051
R-HSA-5653656 Vesicle-mediated transport 8.971365e-01 0.047
R-HSA-983712 Ion channel transport 8.998590e-01 0.046
R-HSA-168898 Toll-like Receptor Cascades 9.020648e-01 0.045
R-HSA-68877 Mitotic Prometaphase 9.042222e-01 0.044
R-HSA-72163 mRNA Splicing - Major Pathway 9.052831e-01 0.043
R-HSA-9609690 HCMV Early Events 9.073700e-01 0.042
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 9.114077e-01 0.040
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 9.143206e-01 0.039
R-HSA-376176 Signaling by ROBO receptors 9.143206e-01 0.039
R-HSA-1483206 Glycerophospholipid biosynthesis 9.143206e-01 0.039
R-HSA-72172 mRNA Splicing 9.162095e-01 0.038
R-HSA-5357801 Programmed Cell Death 9.171383e-01 0.038
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 9.233597e-01 0.035
R-HSA-68882 Mitotic Anaphase 9.267039e-01 0.033
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.275170e-01 0.033
R-HSA-9748784 Drug ADME 9.283211e-01 0.032
R-HSA-9705683 SARS-CoV-2-host interactions 9.358904e-01 0.029
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 9.366021e-01 0.028
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.381244e-01 0.028
R-HSA-913531 Interferon Signaling 9.381244e-01 0.028
R-HSA-72312 rRNA processing 9.386905e-01 0.027
R-HSA-3247509 Chromatin modifying enzymes 9.400447e-01 0.027
R-HSA-15869 Metabolism of nucleotides 9.413691e-01 0.026
R-HSA-8939211 ESR-mediated signaling 9.420203e-01 0.026
R-HSA-9609646 HCMV Infection 9.498598e-01 0.022
R-HSA-388841 Regulation of T cell activation by CD28 family 9.531132e-01 0.021
R-HSA-69620 Cell Cycle Checkpoints 9.541504e-01 0.020
R-HSA-446203 Asparagine N-linked glycosylation 9.569173e-01 0.019
R-HSA-597592 Post-translational protein modification 9.634305e-01 0.016
R-HSA-388396 GPCR downstream signalling 9.769826e-01 0.010
R-HSA-112315 Transmission across Chemical Synapses 9.778717e-01 0.010
R-HSA-1280218 Adaptive Immune System 9.791677e-01 0.009
R-HSA-1474244 Extracellular matrix organization 9.797737e-01 0.009
R-HSA-9694516 SARS-CoV-2 Infection 9.834794e-01 0.007
R-HSA-9006931 Signaling by Nuclear Receptors 9.858877e-01 0.006
R-HSA-372790 Signaling by GPCR 9.883757e-01 0.005
R-HSA-9824439 Bacterial Infection Pathways 9.897067e-01 0.004
R-HSA-168256 Immune System 9.900616e-01 0.004
R-HSA-418594 G alpha (i) signalling events 9.915036e-01 0.004
R-HSA-8978868 Fatty acid metabolism 9.915036e-01 0.004
R-HSA-6798695 Neutrophil degranulation 9.951734e-01 0.002
R-HSA-3700989 Transcriptional Regulation by TP53 9.955917e-01 0.002
R-HSA-9679506 SARS-CoV Infections 9.984151e-01 0.001
R-HSA-392499 Metabolism of proteins 9.986153e-01 0.001
R-HSA-168249 Innate Immune System 9.993279e-01 0.000
R-HSA-556833 Metabolism of lipids 9.994027e-01 0.000
R-HSA-382551 Transport of small molecules 9.998532e-01 0.000
R-HSA-5663205 Infectious disease 9.999032e-01 0.000
R-HSA-9824446 Viral Infection Pathways 9.999699e-01 0.000
R-HSA-9709957 Sensory Perception 9.999911e-01 0.000
R-HSA-1643685 Disease 9.999935e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.810 0.726 1 0.822
CDK18CDK18 0.806 0.778 1 0.844
CDK19CDK19 0.799 0.742 1 0.829
KISKIS 0.799 0.676 1 0.770
P38GP38G 0.797 0.775 1 0.886
CDK17CDK17 0.795 0.758 1 0.876
CDK3CDK3 0.794 0.670 1 0.869
CDK12CDK12 0.792 0.758 1 0.841
CDK7CDK7 0.791 0.739 1 0.801
P38DP38D 0.790 0.761 1 0.875
CDK8CDK8 0.789 0.735 1 0.794
CDK13CDK13 0.789 0.745 1 0.820
DYRK2DYRK2 0.789 0.712 1 0.739
CDK1CDK1 0.786 0.713 1 0.829
CDK5CDK5 0.785 0.719 1 0.772
ERK1ERK1 0.784 0.735 1 0.832
P38BP38B 0.783 0.753 1 0.816
JNK2JNK2 0.783 0.755 1 0.848
HIPK4HIPK4 0.783 0.547 1 0.526
DYRK4DYRK4 0.782 0.686 1 0.834
CDK16CDK16 0.781 0.720 1 0.860
HIPK1HIPK1 0.781 0.657 1 0.718
CDK9CDK9 0.778 0.725 1 0.812
CDK10CDK10 0.776 0.670 1 0.821
CDK14CDK14 0.775 0.713 1 0.806
JNK3JNK3 0.774 0.739 1 0.816
DYRK1BDYRK1B 0.773 0.662 1 0.790
CLK3CLK3 0.772 0.475 1 0.500
DYRK1ADYRK1A 0.772 0.590 1 0.702
P38AP38A 0.770 0.731 1 0.747
MAKMAK 0.770 0.533 -2 0.860
HIPK3HIPK3 0.768 0.633 1 0.690
CDK4CDK4 0.766 0.708 1 0.848
SRPK1SRPK1 0.765 0.346 -3 0.607
DYRK3DYRK3 0.762 0.537 1 0.680
CDK6CDK6 0.761 0.682 1 0.821
CLK2CLK2 0.759 0.391 -3 0.592
PRP4PRP4 0.758 0.690 -3 0.869
JNK1JNK1 0.755 0.657 1 0.847
ERK2ERK2 0.755 0.688 1 0.779
NLKNLK 0.755 0.653 1 0.537
SRPK2SRPK2 0.752 0.274 -3 0.547
MOKMOK 0.748 0.478 1 0.605
CLK1CLK1 0.747 0.368 -3 0.560
CDKL5CDKL5 0.746 0.233 -3 0.624
ICKICK 0.746 0.402 -3 0.644
ERK5ERK5 0.746 0.379 1 0.457
CLK4CLK4 0.744 0.351 -3 0.586
CDK2CDK2 0.744 0.527 1 0.707
MTORMTOR 0.740 0.253 1 0.333
SRPK3SRPK3 0.738 0.241 -3 0.574
CDKL1CDKL1 0.735 0.193 -3 0.624
ERK7ERK7 0.730 0.304 2 0.602
COTCOT 0.728 -0.018 2 0.771
NDR2NDR2 0.726 0.050 -3 0.641
CDC7CDC7 0.725 -0.031 1 0.166
MOSMOS 0.724 0.064 1 0.203
PIM3PIM3 0.723 0.028 -3 0.650
PRKD1PRKD1 0.722 0.058 -3 0.640
TBK1TBK1 0.720 -0.059 1 0.135
AURCAURC 0.718 0.072 -2 0.675
RSK2RSK2 0.718 0.035 -3 0.606
P90RSKP90RSK 0.717 0.045 -3 0.620
PRPKPRPK 0.717 -0.004 -1 0.804
RSK3RSK3 0.717 0.031 -3 0.601
SKMLCKSKMLCK 0.717 0.050 -2 0.850
ATRATR 0.715 -0.010 1 0.196
IKKEIKKE 0.715 -0.090 1 0.137
MST4MST4 0.714 0.008 2 0.807
PRKD2PRKD2 0.714 0.033 -3 0.599
GRK1GRK1 0.714 0.012 -2 0.764
CHAK2CHAK2 0.714 0.015 -1 0.737
PKN3PKN3 0.713 0.004 -3 0.631
GCN2GCN2 0.712 -0.145 2 0.725
IKKBIKKB 0.712 -0.124 -2 0.671
NEK6NEK6 0.712 -0.044 -2 0.786
NDR1NDR1 0.711 -0.016 -3 0.626
MPSK1MPSK1 0.711 0.146 1 0.207
PKCDPKCD 0.711 0.027 2 0.724
PKCAPKCA 0.711 0.061 2 0.691
PDHK4PDHK4 0.711 -0.094 1 0.215
TGFBR2TGFBR2 0.711 -0.048 -2 0.751
MLK2MLK2 0.709 0.021 2 0.764
PIM1PIM1 0.709 0.035 -3 0.603
MNK2MNK2 0.708 0.037 -2 0.769
PKCBPKCB 0.708 0.029 2 0.696
PKACBPKACB 0.708 0.055 -2 0.677
GSK3AGSK3A 0.707 0.207 4 0.389
CAMLCKCAMLCK 0.707 0.030 -2 0.822
WNK1WNK1 0.707 -0.052 -2 0.845
GRK7GRK7 0.707 0.034 1 0.182
NUAK2NUAK2 0.707 0.006 -3 0.626
BMPR2BMPR2 0.707 -0.105 -2 0.810
RSK4RSK4 0.707 0.041 -3 0.593
PKACGPKACG 0.707 0.007 -2 0.730
RAF1RAF1 0.706 -0.159 1 0.157
MAPKAPK2MAPKAPK2 0.706 -0.008 -3 0.566
PDHK1PDHK1 0.706 -0.115 1 0.194
PHKG1PHKG1 0.706 -0.011 -3 0.618
PKCZPKCZ 0.706 0.039 2 0.740
IRE1IRE1 0.706 -0.020 1 0.137
MLK3MLK3 0.706 0.004 2 0.698
ULK2ULK2 0.706 -0.130 2 0.714
CAMK1BCAMK1B 0.706 -0.036 -3 0.626
MAPKAPK3MAPKAPK3 0.705 -0.028 -3 0.586
LATS1LATS1 0.705 0.059 -3 0.652
AKT2AKT2 0.705 0.054 -3 0.540
MLK1MLK1 0.705 -0.087 2 0.755
IKKAIKKA 0.705 -0.056 -2 0.666
NIKNIK 0.704 -0.029 -3 0.634
BCKDKBCKDK 0.704 -0.096 -1 0.725
PKN2PKN2 0.704 -0.037 -3 0.609
PKCGPKCG 0.704 0.017 2 0.683
DAPK2DAPK2 0.703 0.002 -3 0.640
LATS2LATS2 0.703 -0.027 -5 0.677
DSTYKDSTYK 0.702 -0.158 2 0.797
MARK4MARK4 0.702 -0.039 4 0.681
P70S6KBP70S6KB 0.702 -0.002 -3 0.594
SGK3SGK3 0.702 0.034 -3 0.588
AMPKA1AMPKA1 0.701 -0.041 -3 0.634
MNK1MNK1 0.701 0.025 -2 0.771
PKG2PKG2 0.701 0.031 -2 0.674
PRKXPRKX 0.701 0.048 -3 0.539
AMPKA2AMPKA2 0.700 -0.020 -3 0.612
RIPK3RIPK3 0.700 -0.090 3 0.687
GRK5GRK5 0.700 -0.131 -3 0.607
CAMK2DCAMK2D 0.699 -0.063 -3 0.620
BMPR1BBMPR1B 0.699 -0.036 1 0.145
PAK1PAK1 0.699 -0.004 -2 0.786
NEK7NEK7 0.698 -0.176 -3 0.592
NEK9NEK9 0.698 -0.101 2 0.779
PRKD3PRKD3 0.698 -0.004 -3 0.557
DNAPKDNAPK 0.698 -0.020 1 0.195
MSK2MSK2 0.698 -0.011 -3 0.585
MASTLMASTL 0.697 -0.100 -2 0.758
PAK3PAK3 0.697 -0.024 -2 0.769
TSSK1TSSK1 0.696 -0.031 -3 0.660
AURBAURB 0.696 0.023 -2 0.670
IRE2IRE2 0.695 -0.038 2 0.695
NIM1NIM1 0.695 -0.049 3 0.732
QSKQSK 0.695 -0.020 4 0.661
VRK2VRK2 0.694 0.132 1 0.241
AKT1AKT1 0.694 0.037 -3 0.551
CAMK2GCAMK2G 0.694 -0.137 2 0.677
PAK6PAK6 0.694 -0.002 -2 0.707
PIM2PIM2 0.694 0.033 -3 0.568
MSK1MSK1 0.694 0.005 -3 0.579
SMG1SMG1 0.693 -0.053 1 0.179
PKRPKR 0.693 -0.010 1 0.162
PKCHPKCH 0.693 -0.023 2 0.676
AURAAURA 0.692 0.022 -2 0.653
YSK4YSK4 0.692 -0.090 1 0.142
TGFBR1TGFBR1 0.692 -0.040 -2 0.752
ULK1ULK1 0.691 -0.174 -3 0.560
ATMATM 0.691 -0.086 1 0.163
MLK4MLK4 0.691 -0.063 2 0.684
PKACAPKACA 0.691 0.033 -2 0.632
PKCTPKCT 0.691 0.001 2 0.682
TLK2TLK2 0.691 -0.059 1 0.143
ALK4ALK4 0.691 -0.051 -2 0.781
MST3MST3 0.690 0.023 2 0.786
AKT3AKT3 0.690 0.048 -3 0.516
WNK3WNK3 0.690 -0.206 1 0.147
NEK2NEK2 0.690 -0.073 2 0.776
DLKDLK 0.689 -0.183 1 0.163
RIPK1RIPK1 0.689 -0.155 1 0.129
HUNKHUNK 0.689 -0.169 2 0.706
CAMK2ACAMK2A 0.689 -0.037 2 0.663
MELKMELK 0.688 -0.071 -3 0.595
TAO3TAO3 0.688 0.029 1 0.185
TTBK2TTBK2 0.688 -0.160 2 0.631
NUAK1NUAK1 0.688 -0.051 -3 0.575
FAM20CFAM20C 0.687 -0.002 2 0.574
DCAMKL1DCAMKL1 0.687 -0.024 -3 0.598
SIKSIK 0.687 -0.043 -3 0.554
BRSK2BRSK2 0.687 -0.070 -3 0.594
TSSK2TSSK2 0.686 -0.087 -5 0.778
PKCEPKCE 0.686 0.033 2 0.684
PINK1PINK1 0.686 0.083 1 0.353
CAMK2BCAMK2B 0.686 -0.070 2 0.653
CK1ECK1E 0.686 -0.038 -3 0.398
BRSK1BRSK1 0.686 -0.057 -3 0.591
CHAK1CHAK1 0.686 -0.115 2 0.741
QIKQIK 0.686 -0.093 -3 0.598
GRK4GRK4 0.686 -0.173 -2 0.773
PKCIPKCI 0.685 0.007 2 0.724
PAK2PAK2 0.685 -0.042 -2 0.770
SGK1SGK1 0.685 0.058 -3 0.497
BUB1BUB1 0.685 0.071 -5 0.733
CAMK4CAMK4 0.685 -0.118 -3 0.586
ACVR2BACVR2B 0.685 -0.089 -2 0.737
ANKRD3ANKRD3 0.684 -0.189 1 0.162
GSK3BGSK3B 0.684 0.046 4 0.384
GRK6GRK6 0.683 -0.181 1 0.152
MEK1MEK1 0.683 -0.146 2 0.751
ACVR2AACVR2A 0.683 -0.096 -2 0.726
PAK5PAK5 0.682 -0.008 -2 0.656
MEKK1MEKK1 0.682 -0.075 1 0.154
MYLK4MYLK4 0.682 -0.035 -2 0.760
WNK4WNK4 0.681 -0.076 -2 0.840
PERKPERK 0.681 -0.119 -2 0.776
MEKK2MEKK2 0.681 -0.048 2 0.738
ALK2ALK2 0.680 -0.076 -2 0.760
MAPKAPK5MAPKAPK5 0.680 -0.084 -3 0.555
MEK5MEK5 0.680 -0.101 2 0.746
ZAKZAK 0.680 -0.109 1 0.144
LKB1LKB1 0.679 0.065 -3 0.648
SBKSBK 0.679 0.105 -3 0.459
PKN1PKN1 0.679 -0.008 -3 0.545
CK1DCK1D 0.679 -0.026 -3 0.353
PLK4PLK4 0.679 -0.099 2 0.526
NEK5NEK5 0.679 -0.065 1 0.139
CK1G1CK1G1 0.678 -0.073 -3 0.382
KHS1KHS1 0.678 0.048 1 0.165
GCKGCK 0.678 0.010 1 0.177
MARK3MARK3 0.678 -0.065 4 0.604
PAK4PAK4 0.677 -0.005 -2 0.668
TNIKTNIK 0.677 0.032 3 0.859
PHKG2PHKG2 0.677 -0.074 -3 0.569
PDK1PDK1 0.677 -0.015 1 0.181
IRAK4IRAK4 0.677 -0.087 1 0.115
HGKHGK 0.677 0.008 3 0.855
CHK1CHK1 0.676 -0.072 -3 0.605
P70S6KP70S6K 0.676 -0.030 -3 0.532
KHS2KHS2 0.676 0.053 1 0.181
PASKPASK 0.676 -0.025 -3 0.659
PLK1PLK1 0.675 -0.162 -2 0.725
MARK2MARK2 0.675 -0.076 4 0.584
GRK2GRK2 0.675 -0.103 -2 0.667
HPK1HPK1 0.675 -0.006 1 0.178
TAO2TAO2 0.675 -0.006 2 0.774
BMPR1ABMPR1A 0.675 -0.075 1 0.134
DRAK1DRAK1 0.675 -0.138 1 0.132
HRIHRI 0.674 -0.156 -2 0.780
MAP3K15MAP3K15 0.673 -0.020 1 0.157
ROCK2ROCK2 0.673 0.031 -3 0.598
MEKK6MEKK6 0.672 -0.033 1 0.161
PBKPBK 0.671 0.000 1 0.180
MINKMINK 0.671 -0.040 1 0.146
CK1A2CK1A2 0.670 -0.055 -3 0.355
MEKK3MEKK3 0.670 -0.163 1 0.159
DCAMKL2DCAMKL2 0.670 -0.074 -3 0.592
NEK11NEK11 0.670 -0.108 1 0.180
SNRKSNRK 0.669 -0.170 2 0.575
CAMK1GCAMK1G 0.669 -0.085 -3 0.561
LOKLOK 0.668 -0.033 -2 0.703
MRCKBMRCKB 0.668 0.009 -3 0.548
LRRK2LRRK2 0.668 0.025 2 0.775
SMMLCKSMMLCK 0.668 -0.045 -3 0.602
SSTKSSTK 0.667 -0.079 4 0.645
NEK4NEK4 0.667 -0.101 1 0.134
CHK2CHK2 0.667 -0.016 -3 0.495
DAPK3DAPK3 0.666 -0.022 -3 0.603
EEF2KEEF2K 0.666 -0.031 3 0.801
MARK1MARK1 0.665 -0.112 4 0.619
NEK1NEK1 0.665 -0.049 1 0.122
NEK8NEK8 0.665 -0.148 2 0.751
MST2MST2 0.665 -0.097 1 0.154
BRAFBRAF 0.664 -0.173 -4 0.711
YSK1YSK1 0.664 -0.028 2 0.770
GAKGAK 0.664 -0.069 1 0.199
GRK3GRK3 0.664 -0.104 -2 0.635
TLK1TLK1 0.663 -0.184 -2 0.760
MRCKAMRCKA 0.663 -0.009 -3 0.558
HASPINHASPIN 0.663 0.004 -1 0.594
CAMK1DCAMK1D 0.663 -0.053 -3 0.520
PLK3PLK3 0.662 -0.174 2 0.632
VRK1VRK1 0.662 -0.068 2 0.746
SLKSLK 0.662 -0.055 -2 0.659
PKG1PKG1 0.660 -0.011 -2 0.584
CAMKK2CAMKK2 0.659 -0.137 -2 0.682
CK2A2CK2A2 0.659 -0.088 1 0.132
DAPK1DAPK1 0.659 -0.030 -3 0.597
TTBK1TTBK1 0.659 -0.173 2 0.540
MYO3BMYO3B 0.659 0.033 2 0.786
NEK3NEK3 0.658 -0.048 1 0.149
CRIKCRIK 0.658 0.020 -3 0.557
LIMK2_TYRLIMK2_TYR 0.658 0.227 -3 0.651
PDHK3_TYRPDHK3_TYR 0.658 0.219 4 0.769
OSR1OSR1 0.657 -0.031 2 0.756
TAO1TAO1 0.657 -0.003 1 0.152
ROCK1ROCK1 0.656 0.003 -3 0.564
DMPK1DMPK1 0.656 0.024 -3 0.567
CAMKK1CAMKK1 0.656 -0.202 -2 0.675
CAMK1ACAMK1A 0.655 -0.038 -3 0.496
TAK1TAK1 0.653 -0.192 1 0.147
MST1MST1 0.653 -0.130 1 0.144
PKMYT1_TYRPKMYT1_TYR 0.652 0.208 3 0.808
CK2A1CK2A1 0.652 -0.089 1 0.126
MEK2MEK2 0.651 -0.164 2 0.733
IRAK1IRAK1 0.650 -0.235 -1 0.697
AAK1AAK1 0.650 0.013 1 0.192
MAP2K4_TYRMAP2K4_TYR 0.648 0.079 -1 0.822
BIKEBIKE 0.648 -0.034 1 0.185
TESK1_TYRTESK1_TYR 0.648 0.080 3 0.842
RIPK2RIPK2 0.647 -0.216 1 0.128
ASK1ASK1 0.646 -0.078 1 0.154
CK1ACK1A 0.646 -0.064 -3 0.287
STK33STK33 0.646 -0.140 2 0.524
PDHK4_TYRPDHK4_TYR 0.645 0.060 2 0.760
MYO3AMYO3A 0.645 -0.052 1 0.156
PLK2PLK2 0.643 -0.118 -3 0.554
MAP2K6_TYRMAP2K6_TYR 0.643 0.024 -1 0.817
TTKTTK 0.642 -0.082 -2 0.763
MAP2K7_TYRMAP2K7_TYR 0.642 0.012 2 0.747
LIMK1_TYRLIMK1_TYR 0.640 0.062 2 0.769
NEK10_TYRNEK10_TYR 0.639 -0.028 1 0.153
TNNI3K_TYRTNNI3K_TYR 0.638 0.046 1 0.176
JAK2JAK2 0.638 -0.036 1 0.177
RETRET 0.638 -0.063 1 0.169
BMPR2_TYRBMPR2_TYR 0.637 -0.012 -1 0.795
JAK1JAK1 0.637 -0.006 1 0.152
PINK1_TYRPINK1_TYR 0.636 -0.115 1 0.200
CSF1RCSF1R 0.636 -0.028 3 0.753
PDHK1_TYRPDHK1_TYR 0.635 -0.060 -1 0.803
YANK3YANK3 0.635 -0.067 2 0.319
ROS1ROS1 0.635 -0.044 3 0.743
MST1RMST1R 0.635 -0.043 3 0.768
TYK2TYK2 0.634 -0.112 1 0.155
ABL2ABL2 0.632 -0.049 -1 0.718
TNK1TNK1 0.632 0.010 3 0.759
TXKTXK 0.631 -0.054 1 0.137
LCKLCK 0.630 -0.052 -1 0.759
TYRO3TYRO3 0.630 -0.099 3 0.772
FGRFGR 0.629 -0.098 1 0.139
ABL1ABL1 0.628 -0.063 -1 0.718
ALPHAK3ALPHAK3 0.627 -0.120 -1 0.703
EPHB4EPHB4 0.627 -0.098 -1 0.724
STLK3STLK3 0.627 -0.158 1 0.131
JAK3JAK3 0.626 -0.101 1 0.161
EPHA6EPHA6 0.626 -0.095 -1 0.742
YES1YES1 0.626 -0.085 -1 0.778
TNK2TNK2 0.624 -0.060 3 0.687
BLKBLK 0.623 -0.063 -1 0.747
HCKHCK 0.623 -0.114 -1 0.762
DDR1DDR1 0.622 -0.119 4 0.682
ITKITK 0.621 -0.105 -1 0.741
FGFR2FGFR2 0.621 -0.058 3 0.718
KDRKDR 0.620 -0.076 3 0.697
FGFR1FGFR1 0.619 -0.054 3 0.702
KITKIT 0.619 -0.115 3 0.743
WEE1_TYRWEE1_TYR 0.618 -0.061 -1 0.690
FERFER 0.618 -0.163 1 0.151
PDGFRBPDGFRB 0.618 -0.159 3 0.754
METMET 0.617 -0.087 3 0.736
MERTKMERTK 0.616 -0.112 3 0.724
INSRRINSRR 0.615 -0.150 3 0.691
BMXBMX 0.615 -0.102 -1 0.649
TEKTEK 0.615 -0.055 3 0.685
FYNFYN 0.615 -0.081 -1 0.747
FLT3FLT3 0.615 -0.166 3 0.765
DDR2DDR2 0.614 -0.024 3 0.652
AXLAXL 0.614 -0.131 3 0.720
SRMSSRMS 0.614 -0.162 1 0.129
PDGFRAPDGFRA 0.613 -0.160 3 0.753
CK1G3CK1G3 0.613 -0.091 -3 0.251
EPHB1EPHB1 0.611 -0.178 1 0.134
BTKBTK 0.610 -0.187 -1 0.717
EPHA4EPHA4 0.610 -0.122 2 0.632
EPHB3EPHB3 0.610 -0.159 -1 0.708
PTK6PTK6 0.609 -0.159 -1 0.697
TECTEC 0.609 -0.149 -1 0.668
ALKALK 0.609 -0.136 3 0.654
EPHB2EPHB2 0.608 -0.165 -1 0.695
FGFR3FGFR3 0.608 -0.099 3 0.687
FRKFRK 0.607 -0.139 -1 0.741
EPHA1EPHA1 0.607 -0.133 3 0.717
ERBB2ERBB2 0.606 -0.161 1 0.146
FLT1FLT1 0.606 -0.149 -1 0.731
SRCSRC 0.605 -0.112 -1 0.744
NTRK3NTRK3 0.605 -0.130 -1 0.688
LYNLYN 0.605 -0.138 3 0.667
INSRINSR 0.604 -0.149 3 0.689
EGFREGFR 0.603 -0.109 1 0.120
LTKLTK 0.603 -0.158 3 0.675
NTRK1NTRK1 0.602 -0.203 -1 0.729
EPHA7EPHA7 0.602 -0.141 2 0.642
MUSKMUSK 0.602 -0.111 1 0.104
PTK2BPTK2B 0.600 -0.109 -1 0.693
NTRK2NTRK2 0.600 -0.209 3 0.682
MATKMATK 0.599 -0.113 -1 0.630
FLT4FLT4 0.599 -0.174 3 0.688
YANK2YANK2 0.598 -0.096 2 0.339
SYKSYK 0.597 -0.096 -1 0.686
ZAP70ZAP70 0.597 -0.046 -1 0.624
CSKCSK 0.596 -0.146 2 0.642
FGFR4FGFR4 0.596 -0.121 -1 0.678
CK1G2CK1G2 0.595 -0.085 -3 0.318
EPHA8EPHA8 0.595 -0.137 -1 0.693
EPHA3EPHA3 0.594 -0.174 2 0.603
PTK2PTK2 0.594 -0.083 -1 0.704
ERBB4ERBB4 0.591 -0.103 1 0.122
EPHA5EPHA5 0.590 -0.173 2 0.608
IGF1RIGF1R 0.587 -0.151 3 0.617
EPHA2EPHA2 0.584 -0.151 -1 0.662
FESFES 0.573 -0.156 -1 0.638