Motif 289 (n=184)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PPC1 | PRR33 | S215 | ochoa | Proline rich 33 | None |
| A0A1W2PPC1 | PRR33 | S409 | ochoa | Proline rich 33 | None |
| A1L020 | MEX3A | S462 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A4D2B0 | MBLAC1 | S61 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A6ND36 | FAM83G | S666 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A6NEL2 | SOWAHB | S166 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A6NFI3 | ZNF316 | S328 | ochoa | Zinc finger protein 316 | May be involved in transcriptional regulation. {ECO:0000250}. |
| A7E2V4 | ZSWIM8 | S1130 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A8MYA2 | CXorf49; | S281 | ochoa | Uncharacterized protein CXorf49 | None |
| A8MZF0 | PRR33 | S67 | ochoa | Proline-rich protein 33 | None |
| A8MZF0 | PRR33 | S261 | ochoa | Proline-rich protein 33 | None |
| C9JVG2 | ZNF775 | S71 | ochoa | Zinc finger protein 775 | None |
| O00267 | SUPT5H | S666 | ochoa|psp | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00358 | FOXE1 | S329 | ochoa | Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) | Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}. |
| O00443 | PIK3C2A | S1553 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O14508 | SOCS2 | S30 | ochoa | Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2) | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (PubMed:11781573, PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:21980433, PubMed:25505247, PubMed:34857742). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (PubMed:11781573). {ECO:0000269|PubMed:11781573, ECO:0000269|PubMed:21980433, ECO:0000269|PubMed:25505247, ECO:0000269|PubMed:31182716, ECO:0000269|PubMed:34857742, ECO:0000269|PubMed:37816714}. |
| O15015 | ZNF646 | S1442 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15047 | SETD1A | S565 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15119 | TBX3 | S456 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15156 | ZBTB7B | S150 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15173 | PGRMC2 | S90 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O15534 | PER1 | S830 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43379 | WDR62 | S1144 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43586 | PSTPIP1 | S318 | ochoa | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}. |
| O60244 | MED14 | S1112 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O75362 | ZNF217 | S421 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | S2227 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O94819 | KBTBD11 | S314 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O94913 | PCF11 | S777 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94964 | MTCL2 | S1320 | ochoa | Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)] | Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (By similarity). Required for faithful chromosome segregation during mitosis (PubMed:33587225). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:E1U8D0, ECO:0000269|PubMed:33587225}. |
| O95180 | CACNA1H | S758 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95201 | ZNF205 | S94 | ochoa | Transcriptional repressor RHIT (Repressor of heat-inducible transcription) (RhitH) (Zinc finger protein 205) (Zinc finger protein 210) | Transcriptional repressor involved in regulating MPV17L expression (PubMed:22306510). By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:22306510). {ECO:0000269|PubMed:22306510}. |
| O95359 | TACC2 | S137 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95365 | ZBTB7A | S511 | ochoa | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}. |
| P02671 | FGA | S285 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04198 | MYCN | S149 | ochoa | N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37) | Positively regulates the transcription of MYCNOS in neuroblastoma cells. {ECO:0000269|PubMed:24391509}. |
| P04198 | MYCN | S156 | ochoa | N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37) | Positively regulates the transcription of MYCNOS in neuroblastoma cells. {ECO:0000269|PubMed:24391509}. |
| P06401 | PGR | S400 | ochoa|psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P12931 | SRC | S35 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P21333 | FLNA | S1899 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P26368 | U2AF2 | S79 | ochoa | Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) | Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}. |
| P30050 | RPL12 | S38 | ochoa|psp | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680). {ECO:0000269|PubMed:25901680}. |
| P30291 | WEE1 | S150 | ochoa | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30291 | WEE1 | S165 | ochoa|psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30405 | PPIF | S40 | ochoa | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| P30518 | AVPR2 | S255 | psp | Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}. |
| P31277 | HOXD11 | S223 | ochoa | Homeobox protein Hox-D11 (Homeobox protein Hox-4F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P35637 | FUS | S340 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P46531 | NOTCH1 | S2136 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P49790 | NUP153 | Y260 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51798 | CLCN7 | S48 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P52824 | DGKQ | S26 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P53602 | MVD | S104 | ochoa | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}. |
| P61086 | UBE2K | S159 | ochoa | Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:17873885, ECO:0000269|PubMed:19906396, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8702625}. |
| P78559 | MAP1A | S2366 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P81408 | ENTREP3 | S389 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
| Q00536 | CDK16 | S42 | ochoa | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q01995 | TAGLN | S181 | ochoa|psp | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q02040 | AKAP17A | S499 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q02410 | APBA1 | S313 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
| Q07617 | SPAG1 | S418 | ochoa | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
| Q08495 | DMTN | S105 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q0VDD7 | BRME1 | S367 | ochoa | Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}. |
| Q10571 | MN1 | S975 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q12888 | TP53BP1 | S1460 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13029 | PRDM2 | S914 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13233 | MAP3K1 | S34 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13469 | NFATC2 | S110 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13470 | TNK1 | S519 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q14103 | HNRNPD | S83 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q14162 | SCARF1 | S753 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14315 | FLNC | S1893 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S2348 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14526 | HIC1 | S366 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14767 | LTBP2 | S1397 | ochoa | Latent-transforming growth factor beta-binding protein 2 (LTBP-2) | May play an integral structural role in elastic-fiber architectural organization and/or assembly. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}. |
| Q14781 | CBX2 | S302 | ochoa | Chromobox protein homolog 2 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}. |
| Q147X3 | NAA30 | S55 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q16799 | RTN1 | S48 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2TAZ0 | ATG2A | S1327 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q4ZG55 | GREB1 | S1160 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q5C9Z4 | NOM1 | S114 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5SYE7 | NHSL1 | S1167 | ochoa | NHS-like protein 1 | None |
| Q5T481 | RBM20 | S1080 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5T7B8 | KIF24 | S636 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5U651 | RASIP1 | S197 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q5U651 | RASIP1 | S299 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q641Q2 | WASHC2A | S1169 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68DK7 | MSL1 | S126 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6DN90 | IQSEC1 | S417 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6DT37 | CDC42BPG | S1462 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IE81 | JADE1 | S392 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6NV74 | CRACDL | S646 | ochoa | CRACD-like protein | None |
| Q6P1L5 | FAM117B | S106 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6VN20 | RANBP10 | S29 | ochoa | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q6ZN17 | LIN28B | S203 | ochoa | Protein lin-28 homolog B (Lin-28B) | Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000250|UniProtKB:Q45KJ6, ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22118463}. |
| Q70J99 | UNC13D | S150 | ochoa | Protein unc-13 homolog D (Munc13-4) | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}. |
| Q7Z591 | AKNA | S159 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S106 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6I6 | ARHGAP30 | S822 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6J9 | TSEN54 | S267 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q7Z7G8 | VPS13B | S1263 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86X29 | LSR | S467 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XL3 | ANKLE2 | S45 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86XN8 | MEX3D | S514 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q86YV0 | RASAL3 | S377 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IU81 | IRF2BP1 | S478 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IUD2 | ERC1 | S110 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IY67 | RAVER1 | S399 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IZL2 | MAML2 | S491 | ochoa | Mastermind-like protein 2 (Mam-2) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}. |
| Q8N163 | CCAR2 | S124 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N2Y8 | RUSC2 | S1380 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N350 | CBARP | S399 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N612 | FHIP1B | S897 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8N9M1 | C19orf47 | S306 | ochoa | Uncharacterized protein C19orf47 | None |
| Q8NEL9 | DDHD1 | S139 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8TD16 | BICD2 | S568 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TER5 | ARHGEF40 | S961 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TF44 | C2CD4C | S178 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WUU4 | ZNF296 | S69 | ochoa | Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) | May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}. |
| Q8WXX7 | AUTS2 | S1233 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92610 | ZNF592 | S441 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92618 | ZNF516 | S928 | ochoa | Zinc finger protein 516 | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
| Q92733 | PRCC | S114 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92804 | TAF15 | S289 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92945 | KHSRP | S670 | ochoa|psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q92993 | KAT5 | S90 | ochoa|psp | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q969U6 | FBXW5 | S275 | ochoa | F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) | Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}. |
| Q96A73 | KIAA1191 | S251 | ochoa | Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) | Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. |
| Q96B18 | DACT3 | S316 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96BV0 | ZNF775 | S71 | ochoa | Zinc finger protein 775 | May be involved in transcriptional regulation. |
| Q96DX5 | ASB9 | S201 | ochoa | Ankyrin repeat and SOCS box protein 9 (ASB-9) | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465). {ECO:0000269|PubMed:20302626, ECO:0000269|PubMed:22418839, ECO:0000269|PubMed:25654263, ECO:0000269|PubMed:33268465}.; FUNCTION: [Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1. {ECO:0000269|PubMed:20302626}. |
| Q96EA4 | SPDL1 | S555 | ochoa|psp | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100). {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:30258100}. |
| Q96EG3 | ZNF837 | S351 | ochoa | Zinc finger protein 837 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q96F45 | ZNF503 | S129 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
| Q96GV9 | MACIR | S25 | ochoa | Macrophage immunometabolism regulator | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. |
| Q96GY0 | ZC2HC1A | S292 | ochoa | Zinc finger C2HC domain-containing protein 1A | None |
| Q96HA7 | TONSL | S719 | ochoa | Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) | Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:27338793, PubMed:29478807). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30773278}. |
| Q96HR8 | NAF1 | S98 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96L73 | NSD1 | S2573 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MG7 | NSMCE3 | S64 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96N67 | DOCK7 | S873 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NY7 | CLIC6 | S305 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q96PK6 | RBM14 | S161 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96QC0 | PPP1R10 | S545 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96RI0 | F2RL3 | S359 | ochoa | Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) | Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109). {ECO:0000269|PubMed:10079109}. |
| Q96RT7 | TUBGCP6 | S1397 | ochoa|psp | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96S55 | WRNIP1 | S153 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99611 | SEPHS2 | S97 | ochoa | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | Synthesizes selenophosphate from selenide and ATP. {ECO:0000250|UniProtKB:P49903}. |
| Q9BUH8 | BEGAIN | S455 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BV19 | C1orf50 | S43 | ochoa | Uncharacterized protein C1orf50 | None |
| Q9BWW4 | SSBP3 | S347 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Q9BXI6 | TBC1D10A | S383 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BYE2 | TMPRSS13 | S70 | ochoa | Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) | Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). {ECO:0000250|UniProtKB:Q5U405, ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}. |
| Q9BYJ9 | YTHDF1 | S350 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
| Q9BYN7 | ZNF341 | S295 | ochoa | Zinc finger protein 341 | Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. {ECO:0000269|PubMed:29907690, ECO:0000269|PubMed:29907691}. |
| Q9C0C2 | TNKS1BP1 | S762 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C6 | CIPC | S211 | ochoa | CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) | Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}. |
| Q9GZR7 | DDX24 | S287 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H3Q1 | CDC42EP4 | S322 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H6K5 | PRR36 | S173 | ochoa | Proline-rich protein 36 | None |
| Q9H6Y5 | MAGIX | S21 | ochoa | PDZ domain-containing protein MAGIX | None |
| Q9H972 | C14orf93 | S130 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9H987 | SYNPO2L | S421 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9NRI5 | DISC1 | S97 | ochoa | Disrupted in schizophrenia 1 protein | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}. |
| Q9NVE7 | PANK4 | S393 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NZC9 | SMARCAL1 | S151 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9NZN5 | ARHGEF12 | S1327 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Z2 | CALCOCO1 | S563 | ochoa | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Q9P275 | USP36 | S582 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UIW0 | VAX2 | S53 | ochoa | Ventral anterior homeobox 2 | Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}. |
| Q9UKW4 | VAV3 | S786 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9UMN6 | KMT2B | S493 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPU9 | SAMD4A | S447 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQ35 | SRRM2 | S2382 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQC2 | GAB2 | S474 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQL6 | HDAC5 | S53 | ochoa | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y490 | TLN1 | S1940 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B5 | MTCL1 | S87 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S972 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4G2 | PLEKHM1 | S501 | ochoa | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q5PQS0, ECO:0000250|UniProtKB:Q7TSI1, ECO:0000269|PubMed:12820725, ECO:0000269|PubMed:20943950, ECO:0000269|PubMed:25498145, ECO:0000269|PubMed:28325809}.; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. {ECO:0000269|PubMed:25500191}. |
| Q9Y6I3 | EPN1 | S442 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| P52926 | HMGA2 | S59 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| Q96G03 | PGM2 | S186 | Sugiyama | Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2) | Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed:17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed:17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:17804405). In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed:17804405, PubMed:18927083). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083}. |
| Q3KR16 | PLEKHG6 | S697 | PSP | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.002009 | 2.697 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.002626 | 2.581 |
| R-HSA-354192 | Integrin signaling | 0.001444 | 2.840 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000700 | 3.155 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.003000 | 2.523 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.004318 | 2.365 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.005133 | 2.290 |
| R-HSA-9036092 | Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus... | 0.024172 | 1.617 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.070786 | 1.150 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.070786 | 1.150 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.070786 | 1.150 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.093255 | 1.030 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.093255 | 1.030 |
| R-HSA-9645135 | STAT5 Activation | 0.104286 | 0.982 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.115184 | 0.939 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.167724 | 0.775 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.177854 | 0.750 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.177854 | 0.750 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.177854 | 0.750 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.177854 | 0.750 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.217160 | 0.663 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.098007 | 1.009 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.051745 | 1.286 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.051745 | 1.286 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.051745 | 1.286 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.051745 | 1.286 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.051745 | 1.286 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.113534 | 0.945 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.254596 | 0.594 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.254596 | 0.594 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.254596 | 0.594 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.061308 | 1.212 |
| R-HSA-167161 | HIV Transcription Initiation | 0.121520 | 0.915 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.121520 | 0.915 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.263673 | 0.579 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.263673 | 0.579 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.263673 | 0.579 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.263673 | 0.579 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.272641 | 0.564 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.281499 | 0.551 |
| R-HSA-72187 | mRNA 3'-end processing | 0.167539 | 0.776 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.315873 | 0.500 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.332441 | 0.478 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.332441 | 0.478 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.340575 | 0.468 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.340575 | 0.468 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.348610 | 0.458 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.356548 | 0.448 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.364390 | 0.438 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.364390 | 0.438 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.379789 | 0.420 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.379789 | 0.420 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.387348 | 0.412 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.260897 | 0.584 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.402194 | 0.396 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.122074 | 0.913 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.283450 | 0.548 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.301453 | 0.521 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.072527 | 1.139 |
| R-HSA-3928664 | Ephrin signaling | 0.245407 | 0.610 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.324208 | 0.489 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.084973 | 1.071 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.040910 | 1.388 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.033537 | 1.474 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.296958 | 0.527 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.076263 | 1.118 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.137881 | 0.860 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.115184 | 0.939 |
| R-HSA-167172 | Transcription of the HIV genome | 0.067414 | 1.171 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.090491 | 1.043 |
| R-HSA-191650 | Regulation of gap junction activity | 0.070786 | 1.150 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.027762 | 1.557 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.177854 | 0.750 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.072527 | 1.139 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.332441 | 0.478 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.198155 | 0.703 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.016767 | 1.776 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.022851 | 1.641 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.029273 | 1.534 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.029273 | 1.534 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.029273 | 1.534 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.129639 | 0.887 |
| R-HSA-72172 | mRNA Splicing | 0.141812 | 0.848 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.009737 | 2.012 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.017289 | 1.762 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.022851 | 1.641 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.207512 | 0.683 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.121520 | 0.915 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.125564 | 0.901 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.340575 | 0.468 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.233867 | 0.631 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.379789 | 0.420 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.080414 | 1.095 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.290250 | 0.537 |
| R-HSA-72086 | mRNA Capping | 0.348610 | 0.458 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.210573 | 0.677 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.106780 | 0.972 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.387348 | 0.412 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.226691 | 0.645 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.324208 | 0.489 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.340575 | 0.468 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.379789 | 0.420 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.351653 | 0.454 |
| R-HSA-388479 | Vasopressin-like receptors | 0.070786 | 1.150 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.281499 | 0.551 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.315061 | 0.502 |
| R-HSA-157118 | Signaling by NOTCH | 0.214781 | 0.668 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.029273 | 1.534 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.146234 | 0.835 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.394816 | 0.404 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.180565 | 0.743 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.104286 | 0.982 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.187861 | 0.726 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.197746 | 0.704 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.090491 | 1.043 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.298896 | 0.524 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.307436 | 0.512 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.207028 | 0.684 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.134350 | 0.872 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.387348 | 0.412 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.394816 | 0.404 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.416681 | 0.380 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.363650 | 0.439 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.129639 | 0.887 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.068622 | 1.164 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.354873 | 0.450 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.398278 | 0.400 |
| R-HSA-9824272 | Somitogenesis | 0.137881 | 0.860 |
| R-HSA-8875878 | MET promotes cell motility | 0.105692 | 0.976 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.080414 | 1.095 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.394816 | 0.404 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.147091 | 0.832 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.157471 | 0.803 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.187861 | 0.726 |
| R-HSA-171007 | p38MAPK events | 0.207512 | 0.683 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.263673 | 0.579 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.290250 | 0.537 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.387348 | 0.412 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.265408 | 0.576 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.211480 | 0.675 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.010849 | 1.965 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.053595 | 1.271 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.197746 | 0.704 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.307436 | 0.512 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.256385 | 0.591 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.238363 | 0.623 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.245407 | 0.610 |
| R-HSA-2424491 | DAP12 signaling | 0.356548 | 0.448 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.075967 | 1.119 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.009737 | 2.012 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.020887 | 1.680 |
| R-HSA-8964046 | VLDL clearance | 0.115184 | 0.939 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.167724 | 0.775 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.094227 | 1.026 |
| R-HSA-162587 | HIV Life Cycle | 0.168248 | 0.774 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.411042 | 0.386 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.035335 | 1.452 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.171863 | 0.765 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.150449 | 0.823 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.307436 | 0.512 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.138123 | 0.860 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.104286 | 0.982 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.226691 | 0.645 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.263673 | 0.579 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.298896 | 0.524 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.211480 | 0.675 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.394816 | 0.404 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.402194 | 0.396 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.236095 | 0.627 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.402547 | 0.395 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.409482 | 0.388 |
| R-HSA-182971 | EGFR downregulation | 0.364390 | 0.438 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.290250 | 0.537 |
| R-HSA-3214847 | HATs acetylate histones | 0.047194 | 1.326 |
| R-HSA-162906 | HIV Infection | 0.357671 | 0.447 |
| R-HSA-8953854 | Metabolism of RNA | 0.166551 | 0.778 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.025381 | 1.595 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.115184 | 0.939 |
| R-HSA-429947 | Deadenylation of mRNA | 0.307436 | 0.512 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.409482 | 0.388 |
| R-HSA-9607240 | FLT3 Signaling | 0.117510 | 0.930 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.021670 | 1.664 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.324208 | 0.489 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.281499 | 0.551 |
| R-HSA-8853659 | RET signaling | 0.098007 | 1.009 |
| R-HSA-69481 | G2/M Checkpoints | 0.252314 | 0.598 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.125950 | 0.900 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.136585 | 0.865 |
| R-HSA-8851805 | MET activates RAS signaling | 0.177854 | 0.750 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.083157 | 1.080 |
| R-HSA-167044 | Signalling to RAS | 0.272641 | 0.564 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.089639 | 1.048 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.298896 | 0.524 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.298896 | 0.524 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.202586 | 0.693 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.379789 | 0.420 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.262123 | 0.581 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.123942 | 0.907 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.324208 | 0.489 |
| R-HSA-114608 | Platelet degranulation | 0.097969 | 1.009 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.323846 | 0.490 |
| R-HSA-9909396 | Circadian clock | 0.036438 | 1.438 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.147274 | 0.832 |
| R-HSA-422475 | Axon guidance | 0.258577 | 0.587 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.018779 | 1.726 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.217160 | 0.663 |
| R-HSA-177929 | Signaling by EGFR | 0.044664 | 1.350 |
| R-HSA-9707616 | Heme signaling | 0.211480 | 0.675 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.167539 | 0.776 |
| R-HSA-9675108 | Nervous system development | 0.319559 | 0.495 |
| R-HSA-109582 | Hemostasis | 0.397451 | 0.401 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.281499 | 0.551 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.315873 | 0.500 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.315873 | 0.500 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.187861 | 0.726 |
| R-HSA-8939211 | ESR-mediated signaling | 0.014531 | 1.838 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.125950 | 0.900 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.147091 | 0.832 |
| R-HSA-210990 | PECAM1 interactions | 0.157471 | 0.803 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.044664 | 1.350 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.236106 | 0.627 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.307436 | 0.512 |
| R-HSA-9620244 | Long-term potentiation | 0.315873 | 0.500 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.340575 | 0.468 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.111509 | 0.953 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.263673 | 0.579 |
| R-HSA-6806834 | Signaling by MET | 0.094410 | 1.025 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.083322 | 1.079 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.247368 | 0.607 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.217160 | 0.663 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.307436 | 0.512 |
| R-HSA-9839394 | TGFBR3 expression | 0.315873 | 0.500 |
| R-HSA-186763 | Downstream signal transduction | 0.364390 | 0.438 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.269920 | 0.569 |
| R-HSA-201556 | Signaling by ALK | 0.019410 | 1.712 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.177854 | 0.750 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.387348 | 0.412 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.387348 | 0.412 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.156449 | 0.806 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.037934 | 1.421 |
| R-HSA-9758941 | Gastrulation | 0.335029 | 0.475 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.324208 | 0.489 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.023088 | 1.637 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.197746 | 0.704 |
| R-HSA-9629569 | Protein hydroxylation | 0.263673 | 0.579 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.364390 | 0.438 |
| R-HSA-419037 | NCAM1 interactions | 0.416681 | 0.380 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.348610 | 0.458 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.098007 | 1.009 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.207512 | 0.683 |
| R-HSA-180292 | GAB1 signalosome | 0.245407 | 0.610 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.254596 | 0.594 |
| R-HSA-381042 | PERK regulates gene expression | 0.402194 | 0.396 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.314907 | 0.502 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.020523 | 1.688 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.273660 | 0.563 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.100115 | 1.000 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.211480 | 0.675 |
| R-HSA-4839726 | Chromatin organization | 0.048869 | 1.311 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.379789 | 0.420 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.315873 | 0.500 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.340575 | 0.468 |
| R-HSA-5673000 | RAF activation | 0.394816 | 0.404 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.416681 | 0.380 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.055920 | 1.252 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.059122 | 1.228 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.080414 | 1.095 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.111897 | 0.951 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.364390 | 0.438 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.394816 | 0.404 |
| R-HSA-9733709 | Cardiogenesis | 0.379789 | 0.420 |
| R-HSA-373755 | Semaphorin interactions | 0.215942 | 0.666 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.290250 | 0.537 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.298896 | 0.524 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.340575 | 0.468 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.348610 | 0.458 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.394816 | 0.404 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.416681 | 0.380 |
| R-HSA-8983711 | OAS antiviral response | 0.177854 | 0.750 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.245407 | 0.610 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.144433 | 0.840 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.379789 | 0.420 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.409482 | 0.388 |
| R-HSA-2262752 | Cellular responses to stress | 0.394086 | 0.404 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.150449 | 0.823 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.332441 | 0.478 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.387348 | 0.412 |
| R-HSA-187687 | Signalling to ERKs | 0.402194 | 0.396 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.078177 | 1.107 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.342303 | 0.466 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.368021 | 0.434 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.254596 | 0.594 |
| R-HSA-392518 | Signal amplification | 0.394816 | 0.404 |
| R-HSA-212436 | Generic Transcription Pathway | 0.286343 | 0.543 |
| R-HSA-8964038 | LDL clearance | 0.290250 | 0.537 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.215942 | 0.666 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.410932 | 0.386 |
| R-HSA-5205647 | Mitophagy | 0.394816 | 0.404 |
| R-HSA-1500931 | Cell-Cell communication | 0.230858 | 0.637 |
| R-HSA-446728 | Cell junction organization | 0.301668 | 0.520 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.402547 | 0.395 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.351653 | 0.454 |
| R-HSA-186712 | Regulation of beta-cell development | 0.198155 | 0.703 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.287956 | 0.541 |
| R-HSA-622312 | Inflammasomes | 0.340575 | 0.468 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.332441 | 0.478 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.346054 | 0.461 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.323846 | 0.490 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.371539 | 0.430 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.298442 | 0.525 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.153010 | 0.815 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.350468 | 0.455 |
| R-HSA-73887 | Death Receptor Signaling | 0.351653 | 0.454 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.417430 | 0.379 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.417430 | 0.379 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.423794 | 0.373 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.423794 | 0.373 |
| R-HSA-1566948 | Elastic fibre formation | 0.423794 | 0.373 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.427853 | 0.369 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.427853 | 0.369 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.430819 | 0.366 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.430819 | 0.366 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.430819 | 0.366 |
| R-HSA-71336 | Pentose phosphate pathway | 0.430819 | 0.366 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.430819 | 0.366 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.430819 | 0.366 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.432016 | 0.364 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.437760 | 0.359 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.437760 | 0.359 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.437760 | 0.359 |
| R-HSA-167169 | HIV Transcription Elongation | 0.437760 | 0.359 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.437760 | 0.359 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.437760 | 0.359 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.437760 | 0.359 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.437760 | 0.359 |
| R-HSA-5260271 | Diseases of Immune System | 0.437760 | 0.359 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.437760 | 0.359 |
| R-HSA-2559583 | Cellular Senescence | 0.439983 | 0.357 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.442619 | 0.354 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.444617 | 0.352 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.444617 | 0.352 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.444617 | 0.352 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.448508 | 0.348 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.451390 | 0.345 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.451390 | 0.345 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.451390 | 0.345 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.455225 | 0.342 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.456653 | 0.340 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.456653 | 0.340 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.458081 | 0.339 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.458601 | 0.339 |
| R-HSA-8854214 | TBC/RABGAPs | 0.464691 | 0.333 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.464691 | 0.333 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.464691 | 0.333 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.468740 | 0.329 |
| R-HSA-373752 | Netrin-1 signaling | 0.471221 | 0.327 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.471221 | 0.327 |
| R-HSA-2172127 | DAP12 interactions | 0.471221 | 0.327 |
| R-HSA-69236 | G1 Phase | 0.471221 | 0.327 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.471221 | 0.327 |
| R-HSA-74160 | Gene expression (Transcription) | 0.475774 | 0.323 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.477671 | 0.321 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.477671 | 0.321 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.477671 | 0.321 |
| R-HSA-162582 | Signal Transduction | 0.478032 | 0.321 |
| R-HSA-5693538 | Homology Directed Repair | 0.480667 | 0.318 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.480667 | 0.318 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.484043 | 0.315 |
| R-HSA-9675135 | Diseases of DNA repair | 0.484043 | 0.315 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.484043 | 0.315 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.484043 | 0.315 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.484043 | 0.315 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.484606 | 0.315 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.484606 | 0.315 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.484606 | 0.315 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.490195 | 0.310 |
| R-HSA-437239 | Recycling pathway of L1 | 0.490338 | 0.310 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.490338 | 0.310 |
| R-HSA-3371556 | Cellular response to heat stress | 0.492429 | 0.308 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.492429 | 0.308 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.496313 | 0.304 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.496313 | 0.304 |
| R-HSA-9634597 | GPER1 signaling | 0.496556 | 0.304 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.496556 | 0.304 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.502699 | 0.299 |
| R-HSA-9766229 | Degradation of CDH1 | 0.502699 | 0.299 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.508768 | 0.293 |
| R-HSA-109704 | PI3K Cascade | 0.508768 | 0.293 |
| R-HSA-9748787 | Azathioprine ADME | 0.508768 | 0.293 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.511473 | 0.291 |
| R-HSA-194138 | Signaling by VEGF | 0.511657 | 0.291 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.520684 | 0.283 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.524015 | 0.281 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.526534 | 0.279 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.526534 | 0.279 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.538022 | 0.269 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.541627 | 0.266 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.543661 | 0.265 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.549232 | 0.260 |
| R-HSA-112399 | IRS-mediated signalling | 0.549232 | 0.260 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.549232 | 0.260 |
| R-HSA-1483166 | Synthesis of PA | 0.549232 | 0.260 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.549232 | 0.260 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.554735 | 0.256 |
| R-HSA-418990 | Adherens junctions interactions | 0.558288 | 0.253 |
| R-HSA-191859 | snRNP Assembly | 0.560172 | 0.252 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.560172 | 0.252 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.560172 | 0.252 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.565542 | 0.248 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.565542 | 0.248 |
| R-HSA-8951664 | Neddylation | 0.566765 | 0.247 |
| R-HSA-6807070 | PTEN Regulation | 0.569903 | 0.244 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.570847 | 0.243 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.570847 | 0.243 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.570847 | 0.243 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.573373 | 0.242 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.573373 | 0.242 |
| R-HSA-9664407 | Parasite infection | 0.573373 | 0.242 |
| R-HSA-186797 | Signaling by PDGF | 0.576088 | 0.240 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.576088 | 0.240 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.586379 | 0.232 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.586379 | 0.232 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.586379 | 0.232 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.591431 | 0.228 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.596421 | 0.224 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.597096 | 0.224 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.601351 | 0.221 |
| R-HSA-9830369 | Kidney development | 0.601351 | 0.221 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.603690 | 0.219 |
| R-HSA-166520 | Signaling by NTRKs | 0.603690 | 0.219 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.606221 | 0.217 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.613430 | 0.212 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.615784 | 0.211 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.615784 | 0.211 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.616635 | 0.210 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.619821 | 0.208 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.620479 | 0.207 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.620479 | 0.207 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.625116 | 0.204 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.625116 | 0.204 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.625116 | 0.204 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.626131 | 0.203 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.629697 | 0.201 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.634222 | 0.198 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.635444 | 0.197 |
| R-HSA-380287 | Centrosome maturation | 0.638693 | 0.195 |
| R-HSA-8852135 | Protein ubiquitination | 0.638693 | 0.195 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.641552 | 0.193 |
| R-HSA-421270 | Cell-cell junction organization | 0.645874 | 0.190 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.651780 | 0.186 |
| R-HSA-216083 | Integrin cell surface interactions | 0.651780 | 0.186 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.651780 | 0.186 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.653527 | 0.185 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.658886 | 0.181 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.660242 | 0.180 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.660242 | 0.180 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.660242 | 0.180 |
| R-HSA-5619102 | SLC transporter disorders | 0.662299 | 0.179 |
| R-HSA-977225 | Amyloid fiber formation | 0.664396 | 0.178 |
| R-HSA-1640170 | Cell Cycle | 0.671773 | 0.173 |
| R-HSA-72306 | tRNA processing | 0.673717 | 0.172 |
| R-HSA-418555 | G alpha (s) signalling events | 0.676523 | 0.170 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.684420 | 0.165 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.684420 | 0.165 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.684822 | 0.164 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.687550 | 0.163 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.688279 | 0.162 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.692092 | 0.160 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.692092 | 0.160 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.695858 | 0.157 |
| R-HSA-156902 | Peptide chain elongation | 0.695858 | 0.157 |
| R-HSA-9663891 | Selective autophagy | 0.695858 | 0.157 |
| R-HSA-168255 | Influenza Infection | 0.698268 | 0.156 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.699579 | 0.155 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.703254 | 0.153 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.703254 | 0.153 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.706885 | 0.151 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.710471 | 0.148 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.711659 | 0.148 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.714014 | 0.146 |
| R-HSA-391251 | Protein folding | 0.714014 | 0.146 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.714014 | 0.146 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.714014 | 0.146 |
| R-HSA-199991 | Membrane Trafficking | 0.714025 | 0.146 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.714275 | 0.146 |
| R-HSA-9658195 | Leishmania infection | 0.714275 | 0.146 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.716295 | 0.145 |
| R-HSA-69275 | G2/M Transition | 0.716295 | 0.145 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.716370 | 0.145 |
| R-HSA-2029481 | FCGR activation | 0.717513 | 0.144 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.721277 | 0.142 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.724385 | 0.140 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.726738 | 0.139 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.727758 | 0.138 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.727758 | 0.138 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.727758 | 0.138 |
| R-HSA-68886 | M Phase | 0.728566 | 0.138 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.728613 | 0.138 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.730342 | 0.136 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.731090 | 0.136 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.731090 | 0.136 |
| R-HSA-68877 | Mitotic Prometaphase | 0.733413 | 0.135 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.734382 | 0.134 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.737633 | 0.132 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.737633 | 0.132 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.737633 | 0.132 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.737633 | 0.132 |
| R-HSA-190236 | Signaling by FGFR | 0.737633 | 0.132 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.744018 | 0.128 |
| R-HSA-70171 | Glycolysis | 0.744018 | 0.128 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.747152 | 0.127 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.749649 | 0.125 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.750248 | 0.125 |
| R-HSA-1483255 | PI Metabolism | 0.750248 | 0.125 |
| R-HSA-192823 | Viral mRNA Translation | 0.753306 | 0.123 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.756327 | 0.121 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.756327 | 0.121 |
| R-HSA-9833110 | RSV-host interactions | 0.759311 | 0.120 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.768047 | 0.115 |
| R-HSA-211000 | Gene Silencing by RNA | 0.768047 | 0.115 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.770889 | 0.113 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.770889 | 0.113 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.770889 | 0.113 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.770889 | 0.113 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.770889 | 0.113 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.773695 | 0.111 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.773695 | 0.111 |
| R-HSA-397014 | Muscle contraction | 0.777563 | 0.109 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.777563 | 0.109 |
| R-HSA-6803157 | Antimicrobial peptides | 0.779206 | 0.108 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.781912 | 0.107 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.781912 | 0.107 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.781912 | 0.107 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.784584 | 0.105 |
| R-HSA-68882 | Mitotic Anaphase | 0.785590 | 0.105 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.787556 | 0.104 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.789831 | 0.102 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.792381 | 0.101 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.792407 | 0.101 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.797465 | 0.098 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.797465 | 0.098 |
| R-HSA-373760 | L1CAM interactions | 0.797465 | 0.098 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.799420 | 0.097 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.799947 | 0.097 |
| R-HSA-70326 | Glucose metabolism | 0.799947 | 0.097 |
| R-HSA-68875 | Mitotic Prophase | 0.807215 | 0.093 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.809579 | 0.092 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.814220 | 0.089 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.816499 | 0.088 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.820972 | 0.086 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.820972 | 0.086 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.820972 | 0.086 |
| R-HSA-69206 | G1/S Transition | 0.820972 | 0.086 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.823168 | 0.085 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.827480 | 0.082 |
| R-HSA-9843745 | Adipogenesis | 0.835792 | 0.078 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.835792 | 0.078 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.837807 | 0.077 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.839618 | 0.076 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.849390 | 0.071 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.851239 | 0.070 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.852830 | 0.069 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.856652 | 0.067 |
| R-HSA-1632852 | Macroautophagy | 0.856652 | 0.067 |
| R-HSA-388396 | GPCR downstream signalling | 0.858166 | 0.066 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.860151 | 0.065 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.862416 | 0.064 |
| R-HSA-416476 | G alpha (q) signalling events | 0.863738 | 0.064 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.868911 | 0.061 |
| R-HSA-69242 | S Phase | 0.870146 | 0.060 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.873317 | 0.059 |
| R-HSA-913531 | Interferon Signaling | 0.873652 | 0.059 |
| R-HSA-1989781 | PPARA activates gene expression | 0.880912 | 0.055 |
| R-HSA-9612973 | Autophagy | 0.882375 | 0.054 |
| R-HSA-9610379 | HCMV Late Events | 0.883821 | 0.054 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.883821 | 0.054 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.883821 | 0.054 |
| R-HSA-9711097 | Cellular response to starvation | 0.885249 | 0.053 |
| R-HSA-1266738 | Developmental Biology | 0.890421 | 0.050 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.893458 | 0.049 |
| R-HSA-1483257 | Phospholipid metabolism | 0.899377 | 0.046 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.902300 | 0.045 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.904689 | 0.044 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.905862 | 0.043 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.905862 | 0.043 |
| R-HSA-168249 | Innate Immune System | 0.906483 | 0.043 |
| R-HSA-372790 | Signaling by GPCR | 0.916126 | 0.038 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.916828 | 0.038 |
| R-HSA-3781865 | Diseases of glycosylation | 0.917852 | 0.037 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.921825 | 0.035 |
| R-HSA-983712 | Ion channel transport | 0.922788 | 0.035 |
| R-HSA-5617833 | Cilium Assembly | 0.923739 | 0.034 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.923935 | 0.034 |
| R-HSA-8957322 | Metabolism of steroids | 0.924698 | 0.034 |
| R-HSA-9609690 | HCMV Early Events | 0.929205 | 0.032 |
| R-HSA-1474244 | Extracellular matrix organization | 0.929844 | 0.032 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.932631 | 0.030 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.935092 | 0.029 |
| R-HSA-112316 | Neuronal System | 0.939968 | 0.027 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.943374 | 0.025 |
| R-HSA-9748784 | Drug ADME | 0.946782 | 0.024 |
| R-HSA-73894 | DNA Repair | 0.947839 | 0.023 |
| R-HSA-1280218 | Adaptive Immune System | 0.952956 | 0.021 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.952998 | 0.021 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.954152 | 0.020 |
| R-HSA-72312 | rRNA processing | 0.955278 | 0.020 |
| R-HSA-597592 | Post-translational protein modification | 0.956231 | 0.019 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.957973 | 0.019 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.963746 | 0.016 |
| R-HSA-9609646 | HCMV Infection | 0.964247 | 0.016 |
| R-HSA-5688426 | Deubiquitination | 0.966404 | 0.015 |
| R-HSA-195721 | Signaling by WNT | 0.980342 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.981033 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 0.981437 | 0.008 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.982510 | 0.008 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.985064 | 0.007 |
| R-HSA-449147 | Signaling by Interleukins | 0.986509 | 0.006 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.989609 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.991389 | 0.004 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.993863 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.994379 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.994755 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 0.995043 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.995651 | 0.002 |
| R-HSA-9824446 | Viral Infection Pathways | 0.995734 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.995895 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 0.996145 | 0.002 |
| R-HSA-72766 | Translation | 0.996241 | 0.002 |
| R-HSA-168256 | Immune System | 0.996704 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996861 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998112 | 0.001 |
| R-HSA-1643685 | Disease | 0.998910 | 0.000 |
| R-HSA-9679506 | SARS-CoV Infections | 0.999235 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999493 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999967 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.807 | 0.660 | 1 | 0.911 |
CDK19 |
0.805 | 0.634 | 1 | 0.911 |
HIPK2 |
0.800 | 0.592 | 1 | 0.898 |
P38G |
0.800 | 0.671 | 1 | 0.931 |
CDK3 |
0.797 | 0.581 | 1 | 0.922 |
CDK12 |
0.796 | 0.651 | 1 | 0.912 |
KIS |
0.796 | 0.556 | 1 | 0.869 |
CDK17 |
0.796 | 0.644 | 1 | 0.923 |
CDK8 |
0.795 | 0.621 | 1 | 0.886 |
CDK13 |
0.795 | 0.642 | 1 | 0.899 |
CDK5 |
0.794 | 0.637 | 1 | 0.863 |
P38D |
0.792 | 0.648 | 1 | 0.951 |
ERK1 |
0.791 | 0.640 | 1 | 0.901 |
CDK7 |
0.791 | 0.622 | 1 | 0.887 |
CDK1 |
0.790 | 0.622 | 1 | 0.889 |
JNK2 |
0.789 | 0.656 | 1 | 0.913 |
CDK16 |
0.787 | 0.611 | 1 | 0.915 |
CDK9 |
0.785 | 0.628 | 1 | 0.895 |
P38B |
0.784 | 0.635 | 1 | 0.886 |
DYRK2 |
0.782 | 0.572 | 1 | 0.839 |
HIPK4 |
0.779 | 0.426 | 1 | 0.653 |
JNK3 |
0.779 | 0.639 | 1 | 0.895 |
CDK10 |
0.779 | 0.584 | 1 | 0.894 |
P38A |
0.777 | 0.625 | 1 | 0.839 |
HIPK1 |
0.777 | 0.536 | 1 | 0.825 |
CDK14 |
0.776 | 0.613 | 1 | 0.882 |
CLK3 |
0.775 | 0.381 | 1 | 0.624 |
DYRK4 |
0.773 | 0.561 | 1 | 0.912 |
DYRK1B |
0.769 | 0.542 | 1 | 0.870 |
CDK4 |
0.768 | 0.620 | 1 | 0.917 |
SRPK1 |
0.768 | 0.298 | -3 | 0.702 |
CDK6 |
0.768 | 0.603 | 1 | 0.900 |
NLK |
0.767 | 0.565 | 1 | 0.667 |
HIPK3 |
0.763 | 0.512 | 1 | 0.800 |
ERK2 |
0.763 | 0.597 | 1 | 0.855 |
MAK |
0.762 | 0.432 | -2 | 0.807 |
DYRK1A |
0.762 | 0.467 | 1 | 0.809 |
ERK5 |
0.757 | 0.331 | 1 | 0.585 |
JNK1 |
0.757 | 0.562 | 1 | 0.906 |
CLK2 |
0.757 | 0.329 | -3 | 0.685 |
DYRK3 |
0.752 | 0.414 | 1 | 0.793 |
PRP4 |
0.751 | 0.434 | -3 | 0.852 |
SRPK2 |
0.751 | 0.224 | -3 | 0.624 |
CLK1 |
0.751 | 0.314 | -3 | 0.667 |
MTOR |
0.750 | 0.219 | 1 | 0.467 |
CDKL5 |
0.750 | 0.183 | -3 | 0.746 |
ICK |
0.749 | 0.309 | -3 | 0.787 |
CDK2 |
0.749 | 0.447 | 1 | 0.794 |
COT |
0.747 | 0.042 | 2 | 0.804 |
CLK4 |
0.746 | 0.291 | -3 | 0.693 |
ERK7 |
0.744 | 0.297 | 2 | 0.682 |
NEK6 |
0.741 | 0.073 | -2 | 0.827 |
MOK |
0.740 | 0.371 | 1 | 0.722 |
CDKL1 |
0.739 | 0.138 | -3 | 0.748 |
SRPK3 |
0.739 | 0.199 | -3 | 0.668 |
NDR2 |
0.739 | 0.034 | -3 | 0.783 |
CDC7 |
0.734 | -0.043 | 1 | 0.310 |
MST4 |
0.734 | 0.053 | 2 | 0.875 |
MOS |
0.734 | 0.040 | 1 | 0.357 |
PRKD1 |
0.734 | 0.023 | -3 | 0.795 |
GCN2 |
0.733 | -0.066 | 2 | 0.782 |
AURC |
0.732 | 0.082 | -2 | 0.677 |
PIM3 |
0.732 | 0.015 | -3 | 0.780 |
ULK2 |
0.730 | -0.037 | 2 | 0.745 |
PKCD |
0.730 | 0.058 | 2 | 0.783 |
DSTYK |
0.730 | -0.023 | 2 | 0.848 |
PKCA |
0.729 | 0.105 | 2 | 0.760 |
PRPK |
0.729 | -0.022 | -1 | 0.819 |
TBK1 |
0.729 | -0.069 | 1 | 0.276 |
CHAK2 |
0.729 | 0.041 | -1 | 0.804 |
ATR |
0.728 | -0.014 | 1 | 0.362 |
PKN3 |
0.727 | 0.010 | -3 | 0.767 |
PKCB |
0.727 | 0.076 | 2 | 0.768 |
TGFBR2 |
0.726 | -0.012 | -2 | 0.775 |
IKKE |
0.726 | -0.079 | 1 | 0.273 |
WNK1 |
0.725 | -0.005 | -2 | 0.881 |
NEK7 |
0.725 | -0.064 | -3 | 0.817 |
MLK2 |
0.725 | 0.054 | 2 | 0.813 |
RSK3 |
0.725 | 0.020 | -3 | 0.709 |
SKMLCK |
0.724 | 0.037 | -2 | 0.865 |
NDR1 |
0.724 | -0.026 | -3 | 0.769 |
RSK2 |
0.724 | 0.015 | -3 | 0.712 |
GRK1 |
0.724 | 0.048 | -2 | 0.741 |
PKCZ |
0.724 | 0.080 | 2 | 0.798 |
MLK3 |
0.723 | 0.046 | 2 | 0.768 |
NEK9 |
0.723 | 0.013 | 2 | 0.837 |
IKKB |
0.723 | -0.103 | -2 | 0.678 |
PRKD2 |
0.723 | 0.002 | -3 | 0.722 |
PKCG |
0.723 | 0.056 | 2 | 0.752 |
BMPR2 |
0.722 | -0.054 | -2 | 0.844 |
PDHK4 |
0.722 | -0.095 | 1 | 0.369 |
MLK1 |
0.722 | -0.036 | 2 | 0.811 |
PDHK1 |
0.722 | -0.056 | 1 | 0.353 |
P90RSK |
0.722 | 0.015 | -3 | 0.726 |
IRE1 |
0.721 | 0.012 | 1 | 0.298 |
NUAK2 |
0.720 | -0.010 | -3 | 0.764 |
LATS2 |
0.720 | -0.030 | -5 | 0.330 |
PKN2 |
0.720 | -0.007 | -3 | 0.763 |
MNK2 |
0.720 | 0.023 | -2 | 0.794 |
BCKDK |
0.720 | -0.053 | -1 | 0.748 |
IKKA |
0.719 | -0.026 | -2 | 0.674 |
PIM1 |
0.719 | 0.018 | -3 | 0.719 |
RAF1 |
0.719 | -0.142 | 1 | 0.307 |
PHKG1 |
0.718 | -0.003 | -3 | 0.763 |
NIK |
0.717 | -0.024 | -3 | 0.807 |
NEK2 |
0.717 | 0.023 | 2 | 0.831 |
MARK4 |
0.717 | -0.015 | 4 | 0.756 |
CAMK1B |
0.715 | -0.060 | -3 | 0.783 |
MPSK1 |
0.715 | 0.102 | 1 | 0.371 |
PKACG |
0.715 | -0.007 | -2 | 0.739 |
ULK1 |
0.715 | -0.092 | -3 | 0.780 |
PKR |
0.715 | 0.061 | 1 | 0.326 |
CAMLCK |
0.714 | -0.005 | -2 | 0.835 |
PKACB |
0.714 | 0.045 | -2 | 0.683 |
MAPKAPK3 |
0.714 | -0.066 | -3 | 0.726 |
RIPK3 |
0.714 | -0.084 | 3 | 0.739 |
BMPR1B |
0.713 | -0.006 | 1 | 0.267 |
CAMK2D |
0.713 | -0.063 | -3 | 0.783 |
HUNK |
0.713 | -0.062 | 2 | 0.733 |
GRK7 |
0.713 | 0.021 | 1 | 0.308 |
DAPK2 |
0.712 | -0.015 | -3 | 0.799 |
GRK5 |
0.712 | -0.099 | -3 | 0.783 |
GSK3A |
0.712 | 0.152 | 4 | 0.408 |
LATS1 |
0.712 | 0.028 | -3 | 0.796 |
SGK3 |
0.711 | 0.034 | -3 | 0.699 |
MASTL |
0.711 | -0.066 | -2 | 0.777 |
CAMK2G |
0.711 | -0.101 | 2 | 0.720 |
IRE2 |
0.711 | -0.021 | 2 | 0.723 |
MNK1 |
0.711 | 0.007 | -2 | 0.797 |
NIM1 |
0.711 | -0.028 | 3 | 0.775 |
PAK1 |
0.711 | 0.007 | -2 | 0.784 |
P70S6KB |
0.711 | -0.018 | -3 | 0.721 |
MLK4 |
0.710 | -0.005 | 2 | 0.745 |
MAPKAPK2 |
0.710 | -0.047 | -3 | 0.683 |
RSK4 |
0.710 | 0.006 | -3 | 0.686 |
AMPKA1 |
0.710 | -0.064 | -3 | 0.786 |
PKCH |
0.710 | 0.007 | 2 | 0.735 |
SMG1 |
0.710 | -0.020 | 1 | 0.344 |
PAK6 |
0.709 | 0.029 | -2 | 0.698 |
VRK2 |
0.709 | 0.146 | 1 | 0.412 |
TSSK1 |
0.709 | -0.050 | -3 | 0.808 |
DNAPK |
0.709 | -0.008 | 1 | 0.337 |
PKG2 |
0.708 | 0.021 | -2 | 0.684 |
PAK3 |
0.708 | -0.019 | -2 | 0.771 |
PKCT |
0.708 | 0.032 | 2 | 0.744 |
AKT2 |
0.708 | 0.033 | -3 | 0.621 |
TTBK2 |
0.707 | -0.094 | 2 | 0.690 |
PINK1 |
0.707 | 0.106 | 1 | 0.501 |
AURB |
0.707 | 0.021 | -2 | 0.669 |
TGFBR1 |
0.707 | -0.010 | -2 | 0.788 |
MEKK1 |
0.707 | 0.049 | 1 | 0.322 |
WNK3 |
0.707 | -0.151 | 1 | 0.309 |
YSK4 |
0.706 | -0.043 | 1 | 0.283 |
AMPKA2 |
0.706 | -0.053 | -3 | 0.751 |
ANKRD3 |
0.706 | -0.108 | 1 | 0.332 |
TLK2 |
0.706 | -0.026 | 1 | 0.294 |
MST3 |
0.706 | 0.056 | 2 | 0.854 |
ALK4 |
0.705 | -0.030 | -2 | 0.816 |
CHAK1 |
0.705 | -0.040 | 2 | 0.768 |
PRKD3 |
0.705 | -0.033 | -3 | 0.677 |
QSK |
0.704 | -0.015 | 4 | 0.734 |
PRKX |
0.704 | 0.037 | -3 | 0.609 |
ATM |
0.703 | -0.068 | 1 | 0.322 |
PKCI |
0.703 | 0.041 | 2 | 0.780 |
NEK5 |
0.703 | 0.037 | 1 | 0.310 |
RIPK1 |
0.703 | -0.119 | 1 | 0.294 |
MSK2 |
0.702 | -0.028 | -3 | 0.699 |
TAO3 |
0.702 | 0.036 | 1 | 0.328 |
PLK4 |
0.701 | -0.034 | 2 | 0.541 |
DLK |
0.701 | -0.160 | 1 | 0.314 |
NUAK1 |
0.700 | -0.059 | -3 | 0.709 |
PERK |
0.700 | -0.052 | -2 | 0.792 |
PKCE |
0.700 | 0.045 | 2 | 0.750 |
WNK4 |
0.699 | -0.031 | -2 | 0.882 |
PIM2 |
0.699 | 0.004 | -3 | 0.675 |
MEKK2 |
0.699 | -0.009 | 2 | 0.780 |
TSSK2 |
0.699 | -0.128 | -5 | 0.345 |
MELK |
0.699 | -0.073 | -3 | 0.736 |
DCAMKL1 |
0.698 | -0.020 | -3 | 0.721 |
FAM20C |
0.698 | -0.038 | 2 | 0.507 |
AKT1 |
0.697 | 0.015 | -3 | 0.641 |
IRAK4 |
0.697 | -0.030 | 1 | 0.289 |
QIK |
0.696 | -0.089 | -3 | 0.758 |
CAMK2B |
0.696 | -0.075 | 2 | 0.690 |
ZAK |
0.696 | -0.065 | 1 | 0.296 |
AURA |
0.696 | -0.001 | -2 | 0.644 |
GRK6 |
0.696 | -0.148 | 1 | 0.294 |
CAMK2A |
0.696 | -0.056 | 2 | 0.711 |
MSK1 |
0.696 | -0.013 | -3 | 0.694 |
GRK4 |
0.696 | -0.152 | -2 | 0.778 |
ALK2 |
0.696 | -0.042 | -2 | 0.789 |
SIK |
0.695 | -0.059 | -3 | 0.684 |
ACVR2A |
0.695 | -0.082 | -2 | 0.754 |
PLK1 |
0.694 | -0.107 | -2 | 0.751 |
LKB1 |
0.694 | 0.047 | -3 | 0.825 |
PAK2 |
0.694 | -0.051 | -2 | 0.764 |
ACVR2B |
0.694 | -0.083 | -2 | 0.761 |
MEK1 |
0.694 | -0.146 | 2 | 0.763 |
PKACA |
0.693 | 0.015 | -2 | 0.638 |
TNIK |
0.693 | 0.071 | 3 | 0.891 |
MEK5 |
0.693 | -0.090 | 2 | 0.780 |
CHK1 |
0.693 | -0.105 | -3 | 0.764 |
BRSK2 |
0.692 | -0.086 | -3 | 0.743 |
AKT3 |
0.692 | 0.028 | -3 | 0.579 |
BUB1 |
0.692 | 0.021 | -5 | 0.301 |
PAK5 |
0.692 | -0.003 | -2 | 0.642 |
HRI |
0.692 | -0.104 | -2 | 0.807 |
HGK |
0.692 | 0.043 | 3 | 0.888 |
KHS1 |
0.691 | 0.075 | 1 | 0.300 |
CAMK4 |
0.691 | -0.143 | -3 | 0.736 |
CK1E |
0.691 | -0.025 | -3 | 0.505 |
MAP3K15 |
0.691 | 0.019 | 1 | 0.307 |
BMPR1A |
0.690 | -0.045 | 1 | 0.258 |
PAK4 |
0.690 | 0.011 | -2 | 0.653 |
PDK1 |
0.690 | -0.007 | 1 | 0.338 |
GSK3B |
0.690 | 0.034 | 4 | 0.401 |
BRSK1 |
0.690 | -0.075 | -3 | 0.723 |
MARK3 |
0.690 | -0.049 | 4 | 0.678 |
TAO2 |
0.689 | 0.015 | 2 | 0.829 |
PHKG2 |
0.689 | -0.062 | -3 | 0.704 |
KHS2 |
0.689 | 0.072 | 1 | 0.309 |
MEKK6 |
0.689 | 0.007 | 1 | 0.313 |
GCK |
0.689 | 0.015 | 1 | 0.303 |
PKN1 |
0.688 | -0.009 | -3 | 0.656 |
MAPKAPK5 |
0.688 | -0.104 | -3 | 0.680 |
MARK2 |
0.688 | -0.062 | 4 | 0.654 |
DRAK1 |
0.687 | -0.107 | 1 | 0.255 |
MINK |
0.687 | 0.005 | 1 | 0.288 |
NEK11 |
0.687 | -0.045 | 1 | 0.319 |
NEK4 |
0.686 | -0.040 | 1 | 0.290 |
CK1G1 |
0.685 | -0.050 | -3 | 0.483 |
HASPIN |
0.685 | 0.060 | -1 | 0.755 |
SGK1 |
0.685 | 0.027 | -3 | 0.555 |
NEK8 |
0.685 | -0.075 | 2 | 0.803 |
PBK |
0.684 | 0.012 | 1 | 0.348 |
YSK1 |
0.684 | 0.034 | 2 | 0.840 |
MYLK4 |
0.684 | -0.064 | -2 | 0.761 |
MEKK3 |
0.684 | -0.157 | 1 | 0.306 |
LOK |
0.684 | 0.014 | -2 | 0.726 |
BRAF |
0.684 | -0.122 | -4 | 0.707 |
NEK3 |
0.684 | 0.036 | 1 | 0.315 |
EEF2K |
0.683 | 0.005 | 3 | 0.848 |
HPK1 |
0.683 | 0.002 | 1 | 0.298 |
NEK1 |
0.683 | -0.011 | 1 | 0.288 |
GAK |
0.682 | -0.035 | 1 | 0.366 |
PLK3 |
0.682 | -0.118 | 2 | 0.665 |
DCAMKL2 |
0.682 | -0.071 | -3 | 0.730 |
P70S6K |
0.682 | -0.058 | -3 | 0.639 |
SNRK |
0.681 | -0.150 | 2 | 0.605 |
CK1D |
0.681 | -0.022 | -3 | 0.453 |
ROCK2 |
0.681 | 0.017 | -3 | 0.719 |
LRRK2 |
0.681 | 0.032 | 2 | 0.825 |
GRK2 |
0.680 | -0.106 | -2 | 0.671 |
TLK1 |
0.680 | -0.149 | -2 | 0.786 |
PASK |
0.680 | -0.068 | -3 | 0.801 |
CAMKK2 |
0.679 | -0.060 | -2 | 0.698 |
MST2 |
0.679 | -0.078 | 1 | 0.298 |
CAMKK1 |
0.679 | -0.090 | -2 | 0.691 |
SMMLCK |
0.678 | -0.063 | -3 | 0.743 |
CAMK1G |
0.678 | -0.096 | -3 | 0.685 |
MRCKB |
0.677 | 0.001 | -3 | 0.656 |
SSTK |
0.677 | -0.103 | 4 | 0.720 |
SBK |
0.676 | 0.044 | -3 | 0.514 |
MYO3B |
0.676 | 0.071 | 2 | 0.841 |
VRK1 |
0.676 | -0.021 | 2 | 0.768 |
MARK1 |
0.675 | -0.105 | 4 | 0.695 |
SLK |
0.675 | -0.033 | -2 | 0.669 |
CK1A2 |
0.674 | -0.044 | -3 | 0.450 |
TTBK1 |
0.674 | -0.146 | 2 | 0.587 |
OSR1 |
0.673 | 0.015 | 2 | 0.793 |
DAPK3 |
0.673 | -0.039 | -3 | 0.726 |
PDHK3_TYR |
0.670 | 0.195 | 4 | 0.838 |
CK2A2 |
0.670 | -0.063 | 1 | 0.236 |
TAO1 |
0.670 | 0.009 | 1 | 0.292 |
CHK2 |
0.669 | -0.047 | -3 | 0.570 |
TAK1 |
0.669 | -0.118 | 1 | 0.297 |
LIMK2_TYR |
0.669 | 0.182 | -3 | 0.840 |
AAK1 |
0.669 | 0.021 | 1 | 0.336 |
STK33 |
0.669 | -0.072 | 2 | 0.561 |
GRK3 |
0.669 | -0.100 | -2 | 0.633 |
CAMK1D |
0.667 | -0.086 | -3 | 0.617 |
PKG1 |
0.667 | -0.019 | -2 | 0.605 |
BIKE |
0.666 | -0.019 | 1 | 0.346 |
MEK2 |
0.666 | -0.118 | 2 | 0.755 |
DMPK1 |
0.665 | 0.006 | -3 | 0.675 |
IRAK1 |
0.665 | -0.195 | -1 | 0.712 |
MST1 |
0.665 | -0.113 | 1 | 0.286 |
PKMYT1_TYR |
0.665 | 0.160 | 3 | 0.856 |
DAPK1 |
0.663 | -0.050 | -3 | 0.710 |
ROCK1 |
0.663 | -0.010 | -3 | 0.678 |
MRCKA |
0.663 | -0.057 | -3 | 0.675 |
ASK1 |
0.663 | -0.030 | 1 | 0.303 |
CRIK |
0.662 | -0.021 | -3 | 0.648 |
TESK1_TYR |
0.662 | 0.077 | 3 | 0.881 |
MYO3A |
0.661 | -0.016 | 1 | 0.297 |
TTK |
0.661 | -0.041 | -2 | 0.785 |
MAP2K4_TYR |
0.660 | 0.092 | -1 | 0.837 |
PLK2 |
0.660 | -0.075 | -3 | 0.750 |
CAMK1A |
0.659 | -0.073 | -3 | 0.586 |
CK2A1 |
0.659 | -0.074 | 1 | 0.222 |
PDHK4_TYR |
0.657 | 0.044 | 2 | 0.795 |
TNNI3K_TYR |
0.657 | 0.092 | 1 | 0.357 |
RIPK2 |
0.654 | -0.196 | 1 | 0.277 |
MAP2K7_TYR |
0.654 | -0.015 | 2 | 0.785 |
MAP2K6_TYR |
0.653 | 0.007 | -1 | 0.833 |
LIMK1_TYR |
0.653 | 0.055 | 2 | 0.803 |
JAK1 |
0.651 | 0.020 | 1 | 0.303 |
JAK2 |
0.651 | -0.027 | 1 | 0.340 |
RET |
0.650 | -0.039 | 1 | 0.329 |
TYK2 |
0.650 | -0.053 | 1 | 0.319 |
MST1R |
0.649 | -0.020 | 3 | 0.833 |
ROS1 |
0.649 | -0.007 | 3 | 0.798 |
PINK1_TYR |
0.649 | -0.096 | 1 | 0.355 |
BMPR2_TYR |
0.648 | -0.026 | -1 | 0.816 |
YANK3 |
0.647 | -0.049 | 2 | 0.359 |
PDHK1_TYR |
0.647 | -0.074 | -1 | 0.829 |
CSF1R |
0.647 | -0.022 | 3 | 0.809 |
NEK10_TYR |
0.647 | -0.016 | 1 | 0.282 |
TNK1 |
0.646 | 0.028 | 3 | 0.805 |
CK1A |
0.646 | -0.059 | -3 | 0.367 |
ABL2 |
0.644 | -0.031 | -1 | 0.728 |
TNK2 |
0.644 | 0.006 | 3 | 0.771 |
TYRO3 |
0.644 | -0.064 | 3 | 0.824 |
LCK |
0.643 | -0.026 | -1 | 0.752 |
EPHA6 |
0.642 | -0.047 | -1 | 0.765 |
TXK |
0.642 | -0.030 | 1 | 0.288 |
FGR |
0.642 | -0.065 | 1 | 0.307 |
EPHB4 |
0.641 | -0.053 | -1 | 0.735 |
BLK |
0.640 | -0.021 | -1 | 0.760 |
ABL1 |
0.640 | -0.043 | -1 | 0.721 |
JAK3 |
0.640 | -0.072 | 1 | 0.318 |
STLK3 |
0.639 | -0.132 | 1 | 0.275 |
HCK |
0.637 | -0.072 | -1 | 0.753 |
YES1 |
0.637 | -0.081 | -1 | 0.782 |
KDR |
0.634 | -0.051 | 3 | 0.752 |
DDR1 |
0.633 | -0.116 | 4 | 0.747 |
ITK |
0.632 | -0.093 | -1 | 0.719 |
FGFR2 |
0.632 | -0.039 | 3 | 0.775 |
PDGFRB |
0.632 | -0.122 | 3 | 0.820 |
FGFR1 |
0.631 | -0.039 | 3 | 0.767 |
KIT |
0.631 | -0.089 | 3 | 0.803 |
WEE1_TYR |
0.631 | -0.033 | -1 | 0.689 |
FER |
0.630 | -0.136 | 1 | 0.316 |
FLT3 |
0.630 | -0.113 | 3 | 0.820 |
ALPHAK3 |
0.630 | -0.148 | -1 | 0.705 |
MET |
0.630 | -0.080 | 3 | 0.801 |
TEK |
0.630 | -0.027 | 3 | 0.746 |
MERTK |
0.628 | -0.079 | 3 | 0.773 |
PDGFRA |
0.627 | -0.132 | 3 | 0.822 |
EPHB3 |
0.627 | -0.098 | -1 | 0.711 |
AXL |
0.627 | -0.086 | 3 | 0.779 |
INSRR |
0.626 | -0.140 | 3 | 0.750 |
FYN |
0.625 | -0.066 | -1 | 0.741 |
SRMS |
0.624 | -0.139 | 1 | 0.285 |
BMX |
0.624 | -0.090 | -1 | 0.641 |
EPHA4 |
0.624 | -0.106 | 2 | 0.661 |
EPHB1 |
0.624 | -0.158 | 1 | 0.292 |
DDR2 |
0.622 | -0.023 | 3 | 0.727 |
EPHA1 |
0.622 | -0.084 | 3 | 0.784 |
TEC |
0.622 | -0.116 | -1 | 0.658 |
FRK |
0.622 | -0.096 | -1 | 0.753 |
ALK |
0.621 | -0.109 | 3 | 0.734 |
EPHB2 |
0.621 | -0.137 | -1 | 0.705 |
BTK |
0.620 | -0.164 | -1 | 0.690 |
PTK6 |
0.620 | -0.139 | -1 | 0.640 |
NTRK3 |
0.619 | -0.088 | -1 | 0.684 |
LYN |
0.618 | -0.108 | 3 | 0.735 |
EPHA7 |
0.618 | -0.101 | 2 | 0.670 |
LTK |
0.618 | -0.122 | 3 | 0.745 |
FGFR3 |
0.618 | -0.084 | 3 | 0.745 |
INSR |
0.617 | -0.115 | 3 | 0.745 |
FLT1 |
0.617 | -0.130 | -1 | 0.734 |
CK1G3 |
0.617 | -0.078 | -3 | 0.317 |
MATK |
0.617 | -0.078 | -1 | 0.654 |
ERBB2 |
0.617 | -0.136 | 1 | 0.290 |
EGFR |
0.616 | -0.085 | 1 | 0.251 |
SRC |
0.615 | -0.093 | -1 | 0.733 |
NTRK1 |
0.615 | -0.173 | -1 | 0.735 |
NTRK2 |
0.614 | -0.176 | 3 | 0.756 |
PTK2B |
0.613 | -0.093 | -1 | 0.695 |
MUSK |
0.611 | -0.091 | 1 | 0.236 |
FLT4 |
0.611 | -0.153 | 3 | 0.735 |
EPHA3 |
0.610 | -0.144 | 2 | 0.642 |
EPHA8 |
0.610 | -0.098 | -1 | 0.693 |
CSK |
0.609 | -0.120 | 2 | 0.676 |
YANK2 |
0.609 | -0.078 | 2 | 0.370 |
FGFR4 |
0.609 | -0.087 | -1 | 0.671 |
PTK2 |
0.606 | -0.072 | -1 | 0.706 |
ZAP70 |
0.605 | -0.035 | -1 | 0.622 |
SYK |
0.605 | -0.094 | -1 | 0.685 |
EPHA5 |
0.605 | -0.137 | 2 | 0.635 |
ERBB4 |
0.600 | -0.091 | 1 | 0.248 |
IGF1R |
0.597 | -0.137 | 3 | 0.676 |
EPHA2 |
0.597 | -0.120 | -1 | 0.656 |
CK1G2 |
0.595 | -0.086 | -3 | 0.405 |
FES |
0.585 | -0.130 | -1 | 0.614 |