Motif 285 (n=145)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0FGR8 | ESYT2 | S693 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A6NNA2 | SRRM3 | S447 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
| K7EQG2 | None | S49 | ochoa | Uncharacterized protein | None |
| O00267 | SUPT5H | S686 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00267 | SUPT5H | S773 | ochoa|psp | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00358 | FOXE1 | S329 | ochoa | Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) | Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}. |
| O00716 | E2F3 | S124 | psp | Transcription factor E2F3 (E2F-3) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}. |
| O14641 | DVL2 | S597 | psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14654 | IRS4 | S863 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O15209 | ZBTB22 | S592 | ochoa | Zinc finger and BTB domain-containing protein 22 (Protein BING1) (Zinc finger and BTB domain-containing protein 22A) (Zinc finger protein 297) | May be involved in transcriptional regulation. |
| O15211 | RGL2 | S755 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15355 | PPM1G | T177 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43237 | DYNC1LI2 | S443 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43237 | DYNC1LI2 | S446 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43561 | LAT | S109 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O75069 | TMCC2 | S491 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O94887 | FARP2 | S1033 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O94913 | PCF11 | S794 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95049 | TJP3 | S159 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| P02452 | COL1A1 | S171 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S513 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S522 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S543 | ochoa|psp | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S546 | ochoa|psp | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S936 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | T948 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1023 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1029 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1125 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P08572 | COL4A2 | S1475 | ochoa | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. |
| P10589 | NR2F1 | T51 | ochoa | COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) | Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}. |
| P10589 | NR2F1 | T54 | ochoa | COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) | Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}. |
| P10589 | NR2F1 | T63 | ochoa | COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3) | Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}. |
| P10636 | MAPT | S519 | ochoa|psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P12109 | COL6A1 | S348 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12109 | COL6A1 | S387 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P17275 | JUNB | S117 | ochoa | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| P17844 | DDX5 | S24 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P27987 | ITPKB | S228 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P29353 | SHC1 | S80 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P32927 | CSF2RB | S665 | ochoa | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P36871 | PGM1 | S117 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P38159 | RBMX | S116 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P48382 | RFX5 | S505 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49006 | MARCKSL1 | S48 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P53990 | IST1 | S214 | ochoa | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| P56693 | SOX10 | S30 | ochoa|psp | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P58012 | FOXL2 | S33 | ochoa|psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| P60709 | ACTB | S52 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61978 | HNRNPK | S379 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P62736 | ACTA2 | S54 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | S52 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S53 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P67809 | YBX1 | S32 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P68032 | ACTC1 | S54 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S54 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Q01826 | SATB1 | S38 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q01955 | COL4A3 | S382 | ochoa | Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin] | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. |
| Q02078 | MEF2A | S223 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q02241 | KIF23 | S125 | ochoa | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
| Q02388 | COL7A1 | S2600 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q05707 | COL14A1 | S1543 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q05707 | COL14A1 | S1728 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q05707 | COL14A1 | S1734 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q06587 | RING1 | T243 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q08357 | SLC20A2 | S321 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08357 | SLC20A2 | S324 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09472 | EP300 | S255 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12852 | MAP3K12 | S634 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12852 | MAP3K12 | S652 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q13428 | TCOF1 | S734 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14055 | COL9A2 | S329 | ochoa | Collagen alpha-2(IX) chain | Structural component of hyaline cartilage and vitreous of the eye. |
| Q14681 | KCTD2 | S19 | ochoa | BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2) | None |
| Q15056 | EIF4H | S21 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15056 | EIF4H | S24 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15124 | PGM5 | S122 | ochoa | Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) | Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}. |
| Q15464 | SHB | S388 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15768 | EFNB3 | S274 | ochoa | Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for nipah virus and hendra virus. {ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| Q15796 | SMAD2 | S21 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q16763 | UBE2S | T175 | ochoa | Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| Q17RW2 | COL24A1 | T721 | ochoa | Collagen alpha-1(XXIV) chain | May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. {ECO:0000269|PubMed:12874293}. |
| Q2M3G4 | SHROOM1 | S314 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q3ZCQ8 | TIMM50 | S45 | ochoa | Mitochondrial import inner membrane translocase subunit TIM50 | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:30190335, PubMed:38828998). Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:30190335, ECO:0000269|PubMed:38828998}.; FUNCTION: [Isoform 2]: May participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:16008839}. |
| Q4KMQ1 | TPRN | S369 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q5JSL3 | DOCK11 | S1237 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5S007 | LRRK2 | S2032 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q63HR2 | TNS2 | S811 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q6IN85 | PPP4R3A | S768 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IN85 | PPP4R3A | S771 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IN85 | PPP4R3A | S774 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IN85 | PPP4R3A | S777 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IN85 | PPP4R3A | S780 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6IN85 | PPP4R3A | S783 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6ZN18 | AEBP2 | S167 | ochoa | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q6ZNJ1 | NBEAL2 | S1367 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZNJ1 | NBEAL2 | S1376 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q7LBC6 | KDM3B | S311 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7LBC6 | KDM3B | S314 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7LBC6 | KDM3B | S320 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z434 | MAVS | S249 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q86U42 | PABPN1 | S95 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q8N2Y8 | RUSC2 | S342 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8NFC6 | BOD1L1 | S1704 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFW1 | COL22A1 | S962 | ochoa | Collagen alpha-1(XXII) chain | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
| Q8NFW1 | COL22A1 | S1061 | ochoa | Collagen alpha-1(XXII) chain | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
| Q8TAE6 | PPP1R14C | S33 | ochoa | Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Serologically defined breast cancer antigen NY-BR-81) | Inhibitor of the PP1 regulatory subunit PPP1CA. |
| Q8TAP9 | MPLKIP | S80 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TF74 | WIPF2 | S70 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WUF5 | PPP1R13L | S81 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WYP3 | RIN2 | S395 | ochoa | Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
| Q92793 | CREBBP | S281 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92994 | BRF1 | S398 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q969E4 | TCEAL3 | S65 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q96E09 | PABIR1 | S19 | ochoa | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}. |
| Q96E39 | RBMXL1 | S116 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96PE2 | ARHGEF17 | S138 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PG8 | BBC3 | S160 | ochoa | Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis) | [Isoform 3]: Does not affect cell growth. {ECO:0000269|PubMed:11463392}. |
| Q96PV7 | FAM193B | S785 | ochoa | Protein FAM193B | None |
| Q99715 | COL12A1 | S2861 | ochoa | Collagen alpha-1(XII) chain | Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}. |
| Q99715 | COL12A1 | S2864 | ochoa | Collagen alpha-1(XII) chain | Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}. |
| Q9BXP5 | SRRT | Y836 | psp | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BXS0 | COL25A1 | S468 | ochoa | Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}. |
| Q9BZI7 | UPF3B | S25 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9H0W8 | SMG9 | S25 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H3P7 | ACBD3 | S47 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H598 | SLC32A1 | S98 | ochoa | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT) | Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity). {ECO:0000250|UniProtKB:O35458, ECO:0000250|UniProtKB:O35633}. |
| Q9H6A9 | PCNX3 | S1947 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6I2 | SOX17 | S302 | ochoa | Transcription factor SOX-17 | Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. {ECO:0000250|UniProtKB:Q61473}. |
| Q9H6K5 | PRR36 | S116 | ochoa | Proline-rich protein 36 | None |
| Q9H9D4 | ZNF408 | S345 | ochoa | Zinc finger protein 408 (PR domain zinc finger protein 17) | May be involved in transcriptional regulation. |
| Q9HBE1 | PATZ1 | S282 | ochoa | POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) | Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}. |
| Q9HCC9 | ZFYVE28 | S378 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NS62 | THSD1 | S479 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
| Q9P0U4 | CXXC1 | S124 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P260 | RELCH | T143 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P260 | RELCH | S167 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9UKY7 | CDV3 | T56 | ochoa | Protein CDV3 homolog | None |
| Q9UMN6 | KMT2B | S941 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y2H5 | PLEKHA6 | S251 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y446 | PKP3 | S163 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y5B6 | PAXBP1 | S62 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6C2 | EMILIN1 | S839 | ochoa | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity. {ECO:0000269|PubMed:36351433}. |
| Q9Y6G9 | DYNC1LI1 | S458 | ochoa | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
| Q9Y6R0 | NUMBL | S270 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| Q14203 | DCTN1 | S31 | Sugiyama | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8948216 | Collagen chain trimerization | 2.873257e-13 | 12.542 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 9.291756e-11 | 10.032 |
| R-HSA-1474290 | Collagen formation | 2.387160e-09 | 8.622 |
| R-HSA-1474244 | Extracellular matrix organization | 1.850838e-09 | 8.733 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 9.413630e-09 | 8.026 |
| R-HSA-1442490 | Collagen degradation | 1.208992e-08 | 7.918 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.759404e-08 | 7.240 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.017355e-06 | 5.993 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.553435e-06 | 5.184 |
| R-HSA-2214320 | Anchoring fibril formation | 1.014062e-05 | 4.994 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.455223e-05 | 4.610 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.742597e-05 | 4.427 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.673174e-05 | 4.435 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.518146e-05 | 4.345 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 5.313878e-05 | 4.275 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 8.505609e-05 | 4.070 |
| R-HSA-216083 | Integrin cell surface interactions | 1.136408e-04 | 3.944 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.938540e-04 | 3.713 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.563688e-04 | 3.591 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.684132e-04 | 3.571 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 3.883476e-04 | 3.411 |
| R-HSA-9842663 | Signaling by LTK | 3.883476e-04 | 3.411 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.330882e-04 | 3.199 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.330882e-04 | 3.199 |
| R-HSA-419037 | NCAM1 interactions | 6.189092e-04 | 3.208 |
| R-HSA-3000178 | ECM proteoglycans | 6.628774e-04 | 3.179 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 8.508645e-04 | 3.070 |
| R-HSA-162582 | Signal Transduction | 9.206745e-04 | 3.036 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 1.246390e-03 | 2.904 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 1.287072e-03 | 2.890 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.399959e-03 | 2.854 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 1.741983e-03 | 2.759 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.741983e-03 | 2.759 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.596529e-03 | 2.586 |
| R-HSA-3000157 | Laminin interactions | 2.570700e-03 | 2.590 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.478746e-03 | 2.606 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.482539e-03 | 2.605 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 2.847295e-03 | 2.546 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.807514e-03 | 2.552 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.793660e-03 | 2.554 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 3.495424e-03 | 2.457 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.062485e-03 | 2.514 |
| R-HSA-166520 | Signaling by NTRKs | 3.362112e-03 | 2.473 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.338262e-03 | 2.476 |
| R-HSA-186797 | Signaling by PDGF | 3.338262e-03 | 2.476 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.687517e-03 | 2.433 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.871101e-03 | 2.412 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.902082e-03 | 2.409 |
| R-HSA-196025 | Formation of annular gap junctions | 4.205709e-03 | 2.376 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.209997e-03 | 2.376 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 4.977051e-03 | 2.303 |
| R-HSA-190873 | Gap junction degradation | 4.977051e-03 | 2.303 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.649747e-03 | 2.333 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 4.977051e-03 | 2.303 |
| R-HSA-418990 | Adherens junctions interactions | 4.839468e-03 | 2.315 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.634642e-03 | 2.249 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.808776e-03 | 2.236 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.968702e-03 | 2.224 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 6.698568e-03 | 2.174 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 6.777662e-03 | 2.169 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.413689e-03 | 2.193 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.721855e-03 | 2.173 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.721855e-03 | 2.173 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 7.646613e-03 | 2.117 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 7.646613e-03 | 2.117 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 7.646613e-03 | 2.117 |
| R-HSA-201556 | Signaling by ALK | 7.648736e-03 | 2.116 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 8.651449e-03 | 2.063 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 8.651449e-03 | 2.063 |
| R-HSA-451927 | Interleukin-2 family signaling | 8.107903e-03 | 2.091 |
| R-HSA-421270 | Cell-cell junction organization | 9.526285e-03 | 2.021 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 9.712046e-03 | 2.013 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.064476e-02 | 1.973 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.083802e-02 | 1.965 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.236329e-02 | 1.908 |
| R-HSA-9634597 | GPER1 signaling | 1.296937e-02 | 1.887 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.296937e-02 | 1.887 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.199646e-02 | 1.921 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.321828e-02 | 1.879 |
| R-HSA-72172 | mRNA Splicing | 1.359053e-02 | 1.867 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.581625e-02 | 1.801 |
| R-HSA-72187 | mRNA 3'-end processing | 1.556165e-02 | 1.808 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.449186e-02 | 1.839 |
| R-HSA-9675108 | Nervous system development | 1.584553e-02 | 1.800 |
| R-HSA-9758941 | Gastrulation | 1.539225e-02 | 1.813 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.479354e-02 | 1.830 |
| R-HSA-446728 | Cell junction organization | 1.533258e-02 | 1.814 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.724843e-02 | 1.763 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.768361e-02 | 1.752 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.768361e-02 | 1.752 |
| R-HSA-1266738 | Developmental Biology | 1.772672e-02 | 1.751 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.842499e-02 | 1.735 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.160285e-02 | 1.665 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.238835e-02 | 1.650 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.966497e-02 | 1.706 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.156144e-02 | 1.666 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.160285e-02 | 1.665 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.316716e-02 | 1.635 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.316716e-02 | 1.635 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 2.556573e-02 | 1.592 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 2.556573e-02 | 1.592 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 2.556573e-02 | 1.592 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 2.556573e-02 | 1.592 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 2.556573e-02 | 1.592 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 2.556573e-02 | 1.592 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.643065e-02 | 1.578 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.812810e-02 | 1.551 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 2.556573e-02 | 1.592 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.812810e-02 | 1.551 |
| R-HSA-422475 | Axon guidance | 2.548050e-02 | 1.594 |
| R-HSA-8939211 | ESR-mediated signaling | 2.471292e-02 | 1.607 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.812810e-02 | 1.551 |
| R-HSA-157118 | Signaling by NOTCH | 2.595641e-02 | 1.586 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.351001e-02 | 1.629 |
| R-HSA-1500931 | Cell-Cell communication | 2.725767e-02 | 1.565 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.865595e-02 | 1.543 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.865595e-02 | 1.543 |
| R-HSA-4839726 | Chromatin organization | 2.993530e-02 | 1.524 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.999536e-02 | 1.523 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 3.394259e-02 | 1.469 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 3.394259e-02 | 1.469 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 3.347292e-02 | 1.475 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.723823e-02 | 1.429 |
| R-HSA-2424491 | DAP12 signaling | 3.917906e-02 | 1.407 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.917906e-02 | 1.407 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.917906e-02 | 1.407 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.347292e-02 | 1.475 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.688801e-02 | 1.433 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.917906e-02 | 1.407 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.165007e-02 | 1.500 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.159790e-02 | 1.500 |
| R-HSA-74160 | Gene expression (Transcription) | 3.442212e-02 | 1.463 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.723823e-02 | 1.429 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.917906e-02 | 1.407 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.261246e-02 | 1.487 |
| R-HSA-525793 | Myogenesis | 3.165007e-02 | 1.500 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.165007e-02 | 1.500 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.917906e-02 | 1.407 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.610883e-02 | 1.442 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.347292e-02 | 1.475 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.533591e-02 | 1.452 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.575732e-02 | 1.447 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.162177e-02 | 1.500 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.011542e-02 | 1.397 |
| R-HSA-9659379 | Sensory processing of sound | 4.018474e-02 | 1.396 |
| R-HSA-6806834 | Signaling by MET | 4.133306e-02 | 1.384 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 4.224796e-02 | 1.374 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.317314e-02 | 1.365 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.317314e-02 | 1.365 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.317314e-02 | 1.365 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 5.048243e-02 | 1.297 |
| R-HSA-68911 | G2 Phase | 5.864661e-02 | 1.232 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 5.864661e-02 | 1.232 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 5.864661e-02 | 1.232 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 5.864661e-02 | 1.232 |
| R-HSA-390522 | Striated Muscle Contraction | 4.731194e-02 | 1.325 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.910478e-02 | 1.228 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.599966e-02 | 1.252 |
| R-HSA-9930044 | Nuclear RNA decay | 4.522483e-02 | 1.345 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.522483e-02 | 1.345 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 4.731194e-02 | 1.325 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 5.864661e-02 | 1.232 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.555842e-02 | 1.255 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.982841e-02 | 1.303 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.377830e-02 | 1.269 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.574791e-02 | 1.254 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.158941e-02 | 1.287 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.158941e-02 | 1.287 |
| R-HSA-9845576 | Glycosphingolipid transport | 5.377830e-02 | 1.269 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.637638e-02 | 1.249 |
| R-HSA-9931953 | Biofilm formation | 5.825279e-02 | 1.235 |
| R-HSA-8875878 | MET promotes cell motility | 5.825279e-02 | 1.235 |
| R-HSA-8941326 | RUNX2 regulates bone development | 5.377830e-02 | 1.269 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 6.053698e-02 | 1.218 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.063221e-02 | 1.217 |
| R-HSA-9646399 | Aggrephagy | 6.285154e-02 | 1.202 |
| R-HSA-3371568 | Attenuation phase | 6.285154e-02 | 1.202 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.331208e-02 | 1.199 |
| R-HSA-199991 | Membrane Trafficking | 6.512388e-02 | 1.186 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.519579e-02 | 1.186 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.619225e-02 | 1.179 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 6.674109e-02 | 1.176 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 6.674109e-02 | 1.176 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 6.674109e-02 | 1.176 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 6.674109e-02 | 1.176 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 6.674109e-02 | 1.176 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 6.674109e-02 | 1.176 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 6.674109e-02 | 1.176 |
| R-HSA-9020958 | Interleukin-21 signaling | 9.843379e-02 | 1.007 |
| R-HSA-201688 | WNT mediated activation of DVL | 9.843379e-02 | 1.007 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.061886e-01 | 0.974 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.138771e-01 | 0.944 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.215000e-01 | 0.915 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.365509e-01 | 0.865 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.513459e-01 | 0.820 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.513459e-01 | 0.820 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.586487e-01 | 0.800 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.586487e-01 | 0.800 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.658891e-01 | 0.780 |
| R-HSA-3928664 | Ephrin signaling | 1.801848e-01 | 0.744 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.872412e-01 | 0.728 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.872412e-01 | 0.728 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.942373e-01 | 0.712 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.011736e-01 | 0.696 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 9.807876e-02 | 1.008 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.433418e-01 | 0.844 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.951115e-01 | 0.710 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.951115e-01 | 0.710 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.586487e-01 | 0.800 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.316361e-01 | 0.881 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.843379e-02 | 1.007 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.290577e-01 | 0.889 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.290577e-01 | 0.889 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.365509e-01 | 0.865 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.513459e-01 | 0.820 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.658891e-01 | 0.780 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.212966e-02 | 1.142 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.476647e-02 | 1.126 |
| R-HSA-9664420 | Killing mechanisms | 1.586487e-01 | 0.800 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.586487e-01 | 0.800 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.730676e-01 | 0.762 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.756905e-02 | 1.170 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 8.752196e-02 | 1.058 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.997066e-02 | 1.155 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 7.476647e-02 | 1.126 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.756905e-02 | 1.170 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 7.984768e-02 | 1.098 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 7.984768e-02 | 1.098 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 7.984768e-02 | 1.098 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.872412e-01 | 0.728 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.173438e-01 | 0.931 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.173438e-01 | 0.931 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.173438e-01 | 0.931 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.173438e-01 | 0.931 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.919968e-01 | 0.717 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.290577e-01 | 0.889 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.365509e-01 | 0.865 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.365509e-01 | 0.865 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.365509e-01 | 0.865 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.586487e-01 | 0.800 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.658891e-01 | 0.780 |
| R-HSA-167044 | Signalling to RAS | 2.011736e-01 | 0.696 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.632863e-01 | 0.787 |
| R-HSA-6802949 | Signaling by RAS mutants | 7.984768e-02 | 1.098 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 9.061224e-02 | 1.043 |
| R-HSA-74749 | Signal attenuation | 1.061886e-01 | 0.974 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.492750e-01 | 0.826 |
| R-HSA-1181150 | Signaling by NODAL | 1.942373e-01 | 0.712 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 9.061224e-02 | 1.043 |
| R-HSA-8851805 | MET activates RAS signaling | 1.290577e-01 | 0.889 |
| R-HSA-1502540 | Signaling by Activin | 1.513459e-01 | 0.820 |
| R-HSA-2172127 | DAP12 interactions | 7.485634e-02 | 1.126 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.403946e-01 | 0.853 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.290577e-01 | 0.889 |
| R-HSA-68882 | Mitotic Anaphase | 1.483248e-01 | 0.829 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.061886e-01 | 0.974 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.658891e-01 | 0.780 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.801848e-01 | 0.744 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.570840e-01 | 0.804 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.499148e-01 | 0.824 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.469183e-01 | 0.833 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.550334e-01 | 0.810 |
| R-HSA-9664407 | Parasite infection | 1.550334e-01 | 0.810 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.550334e-01 | 0.810 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.290577e-01 | 0.889 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.173438e-01 | 0.931 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.643151e-01 | 0.784 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.801848e-01 | 0.744 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 7.733912e-02 | 1.112 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.859690e-02 | 1.006 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.015927e-01 | 0.993 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.215000e-01 | 0.915 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.365509e-01 | 0.865 |
| R-HSA-445355 | Smooth Muscle Contraction | 9.807876e-02 | 1.008 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.522603e-01 | 0.817 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.253068e-01 | 0.902 |
| R-HSA-8953854 | Metabolism of RNA | 6.746397e-02 | 1.171 |
| R-HSA-194138 | Signaling by VEGF | 1.215979e-01 | 0.915 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.290577e-01 | 0.889 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.730676e-01 | 0.762 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.730676e-01 | 0.762 |
| R-HSA-9671793 | Diseases of hemostasis | 1.872412e-01 | 0.728 |
| R-HSA-437239 | Recycling pathway of L1 | 8.238142e-02 | 1.084 |
| R-HSA-68886 | M Phase | 1.370377e-01 | 0.863 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.439801e-01 | 0.842 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.513459e-01 | 0.820 |
| R-HSA-190828 | Gap junction trafficking | 7.485634e-02 | 1.126 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.316361e-01 | 0.881 |
| R-HSA-3214847 | HATs acetylate histones | 7.062344e-02 | 1.151 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.658891e-01 | 0.780 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.365781e-01 | 0.865 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.011736e-01 | 0.696 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.011736e-01 | 0.696 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.439801e-01 | 0.842 |
| R-HSA-70370 | Galactose catabolism | 1.658891e-01 | 0.780 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.752196e-02 | 1.058 |
| R-HSA-9031628 | NGF-stimulated transcription | 8.493971e-02 | 1.071 |
| R-HSA-2262752 | Cellular responses to stress | 1.146303e-01 | 0.941 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.016309e-01 | 0.993 |
| R-HSA-397014 | Muscle contraction | 1.420320e-01 | 0.848 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 7.733912e-02 | 1.112 |
| R-HSA-9833110 | RSV-host interactions | 7.987451e-02 | 1.098 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.513459e-01 | 0.820 |
| R-HSA-198753 | ERK/MAPK targets | 2.011736e-01 | 0.696 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.645155e-01 | 0.784 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.801848e-01 | 0.744 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.552573e-01 | 0.809 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.153764e-01 | 0.938 |
| R-HSA-3371571 | HSF1-dependent transactivation | 9.275595e-02 | 1.033 |
| R-HSA-9707616 | Heme signaling | 1.230121e-01 | 0.910 |
| R-HSA-5635838 | Activation of SMO | 1.586487e-01 | 0.800 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.062196e-01 | 0.974 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.345413e-01 | 0.871 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.160045e-01 | 0.936 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.467688e-02 | 1.024 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.138771e-01 | 0.944 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.843379e-02 | 1.007 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.365509e-01 | 0.865 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 6.756905e-02 | 1.170 |
| R-HSA-5654743 | Signaling by FGFR4 | 7.239998e-02 | 1.140 |
| R-HSA-5654741 | Signaling by FGFR3 | 7.733912e-02 | 1.112 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.513459e-01 | 0.820 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.765329e-01 | 0.753 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.435949e-01 | 0.843 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.062196e-01 | 0.974 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.223614e-01 | 0.912 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.117450e-01 | 0.952 |
| R-HSA-9833482 | PKR-mediated signaling | 1.765329e-01 | 0.753 |
| R-HSA-1643685 | Disease | 1.405809e-01 | 0.852 |
| R-HSA-210993 | Tie2 Signaling | 1.801848e-01 | 0.744 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.201695e-01 | 0.920 |
| R-HSA-109581 | Apoptosis | 7.149142e-02 | 1.146 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 1.658891e-01 | 0.780 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.365028e-02 | 1.133 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.365509e-01 | 0.865 |
| R-HSA-5357801 | Programmed Cell Death | 1.312874e-01 | 0.882 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.730676e-01 | 0.762 |
| R-HSA-3322077 | Glycogen synthesis | 1.942373e-01 | 0.712 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.489337e-01 | 0.827 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.439801e-01 | 0.842 |
| R-HSA-186712 | Regulation of beta-cell development | 1.145354e-01 | 0.941 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 1.872412e-01 | 0.728 |
| R-HSA-75153 | Apoptotic execution phase | 7.984768e-02 | 1.098 |
| R-HSA-2028269 | Signaling by Hippo | 1.730676e-01 | 0.762 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 7.485634e-02 | 1.126 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.463021e-01 | 0.835 |
| R-HSA-9663891 | Selective autophagy | 2.044931e-01 | 0.689 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.075024e-01 | 0.683 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.080506e-01 | 0.682 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.080506e-01 | 0.682 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.085475e-01 | 0.681 |
| R-HSA-5688426 | Deubiquitination | 2.146846e-01 | 0.668 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.148688e-01 | 0.668 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.148688e-01 | 0.668 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.148688e-01 | 0.668 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.148688e-01 | 0.668 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.216288e-01 | 0.654 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.216288e-01 | 0.654 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.216288e-01 | 0.654 |
| R-HSA-3000170 | Syndecan interactions | 2.216288e-01 | 0.654 |
| R-HSA-418555 | G alpha (s) signalling events | 2.264832e-01 | 0.645 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.283309e-01 | 0.641 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.283309e-01 | 0.641 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.332863e-01 | 0.632 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.349758e-01 | 0.629 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.349758e-01 | 0.629 |
| R-HSA-9839394 | TGFBR3 expression | 2.349758e-01 | 0.629 |
| R-HSA-3214842 | HDMs demethylate histones | 2.349758e-01 | 0.629 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.349758e-01 | 0.629 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.355623e-01 | 0.628 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.355623e-01 | 0.628 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.360747e-01 | 0.627 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.392512e-01 | 0.621 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.415638e-01 | 0.617 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.415638e-01 | 0.617 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.415638e-01 | 0.617 |
| R-HSA-190236 | Signaling by FGFR | 2.424300e-01 | 0.615 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.440187e-01 | 0.613 |
| R-HSA-2559583 | Cellular Senescence | 2.470007e-01 | 0.607 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.480956e-01 | 0.605 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.480956e-01 | 0.605 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.480956e-01 | 0.605 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.480956e-01 | 0.605 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.545714e-01 | 0.594 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.545714e-01 | 0.594 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.545714e-01 | 0.594 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.545714e-01 | 0.594 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.545714e-01 | 0.594 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.551618e-01 | 0.593 |
| R-HSA-72086 | mRNA Capping | 2.609919e-01 | 0.583 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.609919e-01 | 0.583 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.609919e-01 | 0.583 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.609919e-01 | 0.583 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.609919e-01 | 0.583 |
| R-HSA-9658195 | Leishmania infection | 2.627734e-01 | 0.580 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.627734e-01 | 0.580 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.647210e-01 | 0.577 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.647210e-01 | 0.577 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.654753e-01 | 0.576 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.673575e-01 | 0.573 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.673575e-01 | 0.573 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.673575e-01 | 0.573 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.710950e-01 | 0.567 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.736687e-01 | 0.563 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.736687e-01 | 0.563 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.736687e-01 | 0.563 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.736687e-01 | 0.563 |
| R-HSA-68877 | Mitotic Prometaphase | 2.771090e-01 | 0.557 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.774678e-01 | 0.557 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.799258e-01 | 0.553 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.806532e-01 | 0.552 |
| R-HSA-212436 | Generic Transcription Pathway | 2.823948e-01 | 0.549 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 2.861295e-01 | 0.543 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.861295e-01 | 0.543 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.861295e-01 | 0.543 |
| R-HSA-354192 | Integrin signaling | 2.861295e-01 | 0.543 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.861295e-01 | 0.543 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 2.861295e-01 | 0.543 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.861295e-01 | 0.543 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.902026e-01 | 0.537 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.902026e-01 | 0.537 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 2.902026e-01 | 0.537 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.922801e-01 | 0.534 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.922801e-01 | 0.534 |
| R-HSA-1640170 | Cell Cycle | 2.947970e-01 | 0.530 |
| R-HSA-195721 | Signaling by WNT | 2.952680e-01 | 0.530 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.983780e-01 | 0.525 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.983780e-01 | 0.525 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.983780e-01 | 0.525 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.983780e-01 | 0.525 |
| R-HSA-187687 | Signalling to ERKs | 3.044238e-01 | 0.517 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.044238e-01 | 0.517 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 3.060832e-01 | 0.514 |
| R-HSA-373760 | L1CAM interactions | 3.092523e-01 | 0.510 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.104179e-01 | 0.508 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.104179e-01 | 0.508 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.104179e-01 | 0.508 |
| R-HSA-8853659 | RET signaling | 3.104179e-01 | 0.508 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 3.163607e-01 | 0.500 |
| R-HSA-4641258 | Degradation of DVL | 3.163607e-01 | 0.500 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.163607e-01 | 0.500 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.163607e-01 | 0.500 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.187419e-01 | 0.497 |
| R-HSA-1566948 | Elastic fibre formation | 3.222526e-01 | 0.492 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.222526e-01 | 0.492 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.222526e-01 | 0.492 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.250519e-01 | 0.488 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.250519e-01 | 0.488 |
| R-HSA-3371556 | Cellular response to heat stress | 3.250519e-01 | 0.488 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.280942e-01 | 0.484 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.280942e-01 | 0.484 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.280942e-01 | 0.484 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.338857e-01 | 0.476 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.338857e-01 | 0.476 |
| R-HSA-167169 | HIV Transcription Elongation | 3.338857e-01 | 0.476 |
| R-HSA-202433 | Generation of second messenger molecules | 3.338857e-01 | 0.476 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.338857e-01 | 0.476 |
| R-HSA-8982491 | Glycogen metabolism | 3.338857e-01 | 0.476 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.396277e-01 | 0.469 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.407593e-01 | 0.468 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.407593e-01 | 0.468 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.407593e-01 | 0.468 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.453205e-01 | 0.462 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.453205e-01 | 0.462 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.565604e-01 | 0.448 |
| R-HSA-1474165 | Reproduction | 3.594580e-01 | 0.444 |
| R-HSA-5683826 | Surfactant metabolism | 3.621083e-01 | 0.441 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.621083e-01 | 0.441 |
| R-HSA-69236 | G1 Phase | 3.621083e-01 | 0.441 |
| R-HSA-9843745 | Adipogenesis | 3.625565e-01 | 0.441 |
| R-HSA-9909396 | Circadian clock | 3.656494e-01 | 0.437 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.676087e-01 | 0.435 |
| R-HSA-168256 | Immune System | 3.693977e-01 | 0.433 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.730620e-01 | 0.428 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.730620e-01 | 0.428 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.730620e-01 | 0.428 |
| R-HSA-597592 | Post-translational protein modification | 3.780311e-01 | 0.422 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.784686e-01 | 0.422 |
| R-HSA-168249 | Innate Immune System | 3.825873e-01 | 0.417 |
| R-HSA-1632852 | Macroautophagy | 3.962468e-01 | 0.402 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.022877e-01 | 0.395 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.048151e-01 | 0.393 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.048151e-01 | 0.393 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.048151e-01 | 0.393 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.048151e-01 | 0.393 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.099498e-01 | 0.387 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.099498e-01 | 0.387 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.099498e-01 | 0.387 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.099498e-01 | 0.387 |
| R-HSA-9609646 | HCMV Infection | 4.128005e-01 | 0.384 |
| R-HSA-72649 | Translation initiation complex formation | 4.150405e-01 | 0.382 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.150405e-01 | 0.382 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.200876e-01 | 0.377 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.250915e-01 | 0.372 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.250915e-01 | 0.372 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.250915e-01 | 0.372 |
| R-HSA-177929 | Signaling by EGFR | 4.250915e-01 | 0.372 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.261611e-01 | 0.370 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 4.261611e-01 | 0.370 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.291110e-01 | 0.367 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.300525e-01 | 0.366 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.311142e-01 | 0.365 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.349710e-01 | 0.362 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.349710e-01 | 0.362 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.349710e-01 | 0.362 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.379132e-01 | 0.359 |
| R-HSA-1989781 | PPARA activates gene expression | 4.408311e-01 | 0.356 |
| R-HSA-9612973 | Autophagy | 4.437407e-01 | 0.353 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.446819e-01 | 0.352 |
| R-HSA-983189 | Kinesins | 4.446819e-01 | 0.352 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.446819e-01 | 0.352 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.466421e-01 | 0.350 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.494751e-01 | 0.347 |
| R-HSA-450294 | MAP kinase activation | 4.494751e-01 | 0.347 |
| R-HSA-1268020 | Mitochondrial protein import | 4.542271e-01 | 0.343 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.542271e-01 | 0.343 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.542271e-01 | 0.343 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.542271e-01 | 0.343 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.552957e-01 | 0.342 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.589385e-01 | 0.338 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.589385e-01 | 0.338 |
| R-HSA-373755 | Semaphorin interactions | 4.589385e-01 | 0.338 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.589385e-01 | 0.338 |
| R-HSA-8848021 | Signaling by PTK6 | 4.589385e-01 | 0.338 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.589385e-01 | 0.338 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.636094e-01 | 0.334 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.671030e-01 | 0.331 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.728316e-01 | 0.325 |
| R-HSA-167172 | Transcription of the HIV genome | 4.818963e-01 | 0.317 |
| R-HSA-449147 | Signaling by Interleukins | 4.861041e-01 | 0.313 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.891224e-01 | 0.311 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.908062e-01 | 0.309 |
| R-HSA-448424 | Interleukin-17 signaling | 4.908062e-01 | 0.309 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.918824e-01 | 0.308 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.952040e-01 | 0.305 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.952040e-01 | 0.305 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.952040e-01 | 0.305 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.952040e-01 | 0.305 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.995640e-01 | 0.301 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.995640e-01 | 0.301 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.038867e-01 | 0.298 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.038867e-01 | 0.298 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.038867e-01 | 0.298 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.038867e-01 | 0.298 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.081723e-01 | 0.294 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.081723e-01 | 0.294 |
| R-HSA-380287 | Centrosome maturation | 5.124211e-01 | 0.290 |
| R-HSA-8852135 | Protein ubiquitination | 5.124211e-01 | 0.290 |
| R-HSA-5663205 | Infectious disease | 5.159913e-01 | 0.287 |
| R-HSA-5689603 | UCH proteinases | 5.166335e-01 | 0.287 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.208097e-01 | 0.283 |
| R-HSA-3781865 | Diseases of glycosylation | 5.242652e-01 | 0.280 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.249501e-01 | 0.280 |
| R-HSA-4086400 | PCP/CE pathway | 5.249501e-01 | 0.280 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.249501e-01 | 0.280 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.249501e-01 | 0.280 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.290551e-01 | 0.276 |
| R-HSA-69275 | G2/M Transition | 5.295275e-01 | 0.276 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.331247e-01 | 0.273 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.337430e-01 | 0.273 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.371595e-01 | 0.270 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.411597e-01 | 0.267 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.411597e-01 | 0.267 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.450782e-01 | 0.264 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.451255e-01 | 0.264 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.490573e-01 | 0.260 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.490573e-01 | 0.260 |
| R-HSA-9609690 | HCMV Early Events | 5.552468e-01 | 0.256 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.568199e-01 | 0.254 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.644499e-01 | 0.248 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.644499e-01 | 0.248 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.652552e-01 | 0.248 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.682158e-01 | 0.245 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.726557e-01 | 0.242 |
| R-HSA-9640148 | Infection with Enterobacteria | 5.726557e-01 | 0.242 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.756510e-01 | 0.240 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.756510e-01 | 0.240 |
| R-HSA-1280218 | Adaptive Immune System | 5.770693e-01 | 0.239 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.865660e-01 | 0.232 |
| R-HSA-391251 | Protein folding | 5.865660e-01 | 0.232 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.901420e-01 | 0.229 |
| R-HSA-6798695 | Neutrophil degranulation | 5.939740e-01 | 0.226 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.041417e-01 | 0.219 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.041417e-01 | 0.219 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.086203e-01 | 0.216 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.109624e-01 | 0.214 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.109624e-01 | 0.214 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.109624e-01 | 0.214 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.143289e-01 | 0.212 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.198796e-01 | 0.208 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.242558e-01 | 0.205 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.242558e-01 | 0.205 |
| R-HSA-1483255 | PI Metabolism | 6.242558e-01 | 0.205 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.307324e-01 | 0.200 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.329723e-01 | 0.199 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.370981e-01 | 0.196 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.370981e-01 | 0.196 |
| R-HSA-69239 | Synthesis of DNA | 6.433549e-01 | 0.192 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.464430e-01 | 0.189 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.464430e-01 | 0.189 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.464430e-01 | 0.189 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.495046e-01 | 0.187 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.495046e-01 | 0.187 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.522586e-01 | 0.186 |
| R-HSA-202403 | TCR signaling | 6.525398e-01 | 0.185 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.525398e-01 | 0.185 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.525398e-01 | 0.185 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.585322e-01 | 0.181 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.614898e-01 | 0.179 |
| R-HSA-9824446 | Viral Infection Pathways | 6.650297e-01 | 0.177 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.702109e-01 | 0.174 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.759007e-01 | 0.170 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.759007e-01 | 0.170 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.787089e-01 | 0.168 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.787089e-01 | 0.168 |
| R-HSA-913531 | Interferon Signaling | 6.803106e-01 | 0.167 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.842531e-01 | 0.165 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.842531e-01 | 0.165 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.903365e-01 | 0.161 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.923917e-01 | 0.160 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.923917e-01 | 0.160 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.977015e-01 | 0.156 |
| R-HSA-109582 | Hemostasis | 6.991768e-01 | 0.155 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.125881e-01 | 0.147 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.347280e-01 | 0.134 |
| R-HSA-9679506 | SARS-CoV Infections | 7.361129e-01 | 0.133 |
| R-HSA-5173105 | O-linked glycosylation | 7.370299e-01 | 0.133 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.393118e-01 | 0.131 |
| R-HSA-6807070 | PTEN Regulation | 7.415741e-01 | 0.130 |
| R-HSA-5668914 | Diseases of metabolism | 7.458832e-01 | 0.127 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.504301e-01 | 0.125 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.589847e-01 | 0.120 |
| R-HSA-69242 | S Phase | 7.631522e-01 | 0.117 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.631522e-01 | 0.117 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.712737e-01 | 0.113 |
| R-HSA-9609507 | Protein localization | 7.732605e-01 | 0.112 |
| R-HSA-69306 | DNA Replication | 7.732605e-01 | 0.112 |
| R-HSA-73887 | Death Receptor Signaling | 7.752302e-01 | 0.111 |
| R-HSA-162587 | HIV Life Cycle | 7.810378e-01 | 0.107 |
| R-HSA-9610379 | HCMV Late Events | 7.810378e-01 | 0.107 |
| R-HSA-877300 | Interferon gamma signaling | 7.848266e-01 | 0.105 |
| R-HSA-392499 | Metabolism of proteins | 7.924054e-01 | 0.101 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.941174e-01 | 0.100 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.981374e-01 | 0.098 |
| R-HSA-5619102 | SLC transporter disorders | 7.993416e-01 | 0.097 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.112422e-01 | 0.091 |
| R-HSA-168255 | Influenza Infection | 8.208832e-01 | 0.086 |
| R-HSA-5617833 | Cilium Assembly | 8.373059e-01 | 0.077 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.387226e-01 | 0.076 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.547967e-01 | 0.068 |
| R-HSA-6805567 | Keratinization | 8.597930e-01 | 0.066 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.669692e-01 | 0.062 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.724097e-01 | 0.059 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.784374e-01 | 0.056 |
| R-HSA-162906 | HIV Infection | 8.833536e-01 | 0.054 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.853810e-01 | 0.053 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.021233e-01 | 0.045 |
| R-HSA-388396 | GPCR downstream signalling | 9.161829e-01 | 0.038 |
| R-HSA-112316 | Neuronal System | 9.263725e-01 | 0.033 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.280366e-01 | 0.032 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.358162e-01 | 0.029 |
| R-HSA-1483257 | Phospholipid metabolism | 9.358162e-01 | 0.029 |
| R-HSA-372790 | Signaling by GPCR | 9.484745e-01 | 0.023 |
| R-HSA-8957322 | Metabolism of steroids | 9.502906e-01 | 0.022 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.575920e-01 | 0.019 |
| R-HSA-73894 | DNA Repair | 9.638275e-01 | 0.016 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.707475e-01 | 0.013 |
| R-HSA-382551 | Transport of small molecules | 9.761223e-01 | 0.010 |
| R-HSA-72766 | Translation | 9.805455e-01 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.845593e-01 | 0.007 |
| R-HSA-9709957 | Sensory Perception | 9.989963e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998646e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.776 | 0.407 | 1 | 0.911 |
CDK18 |
0.771 | 0.416 | 1 | 0.922 |
HIPK4 |
0.767 | 0.362 | 1 | 0.849 |
CDK19 |
0.765 | 0.407 | 1 | 0.902 |
MAK |
0.763 | 0.411 | -2 | 0.880 |
CLK3 |
0.762 | 0.263 | 1 | 0.852 |
CDK3 |
0.760 | 0.349 | 1 | 0.911 |
CDK8 |
0.760 | 0.393 | 1 | 0.907 |
CDK5 |
0.759 | 0.392 | 1 | 0.932 |
CDK1 |
0.759 | 0.363 | 1 | 0.919 |
CDK17 |
0.759 | 0.387 | 1 | 0.900 |
CDK7 |
0.759 | 0.375 | 1 | 0.922 |
KIS |
0.759 | 0.332 | 1 | 0.910 |
DYRK2 |
0.758 | 0.361 | 1 | 0.917 |
HIPK1 |
0.758 | 0.367 | 1 | 0.922 |
P38G |
0.757 | 0.390 | 1 | 0.888 |
P38B |
0.753 | 0.400 | 1 | 0.898 |
JNK2 |
0.753 | 0.387 | 1 | 0.896 |
CDK13 |
0.753 | 0.361 | 1 | 0.921 |
CDK12 |
0.753 | 0.371 | 1 | 0.907 |
P38A |
0.750 | 0.407 | 1 | 0.905 |
SRPK1 |
0.750 | 0.205 | -3 | 0.781 |
CLK2 |
0.749 | 0.247 | -3 | 0.771 |
CDK16 |
0.749 | 0.363 | 1 | 0.917 |
ERK1 |
0.748 | 0.377 | 1 | 0.895 |
ICK |
0.747 | 0.312 | -3 | 0.837 |
P38D |
0.747 | 0.369 | 1 | 0.900 |
CDK14 |
0.747 | 0.370 | 1 | 0.927 |
NDR2 |
0.747 | 0.220 | -3 | 0.822 |
CDK10 |
0.746 | 0.335 | 1 | 0.925 |
DYRK4 |
0.746 | 0.336 | 1 | 0.917 |
DYRK1A |
0.745 | 0.325 | 1 | 0.902 |
CDKL5 |
0.745 | 0.213 | -3 | 0.802 |
JNK3 |
0.743 | 0.356 | 1 | 0.916 |
CDK9 |
0.742 | 0.342 | 1 | 0.918 |
MTOR |
0.742 | 0.317 | 1 | 0.696 |
PRKD1 |
0.739 | 0.181 | -3 | 0.823 |
DYRK1B |
0.739 | 0.319 | 1 | 0.920 |
HIPK3 |
0.739 | 0.325 | 1 | 0.881 |
NLK |
0.738 | 0.285 | 1 | 0.857 |
MOK |
0.738 | 0.335 | 1 | 0.881 |
CDKL1 |
0.737 | 0.195 | -3 | 0.806 |
PIM3 |
0.735 | 0.098 | -3 | 0.837 |
COT |
0.735 | 0.072 | 2 | 0.553 |
MOS |
0.733 | 0.108 | 1 | 0.692 |
DYRK3 |
0.732 | 0.268 | 1 | 0.898 |
ERK5 |
0.731 | 0.184 | 1 | 0.792 |
SRPK2 |
0.731 | 0.147 | -3 | 0.716 |
PRKD2 |
0.730 | 0.119 | -3 | 0.779 |
CLK4 |
0.730 | 0.192 | -3 | 0.772 |
CDC7 |
0.729 | 0.085 | 1 | 0.625 |
RSK2 |
0.729 | 0.099 | -3 | 0.782 |
CDK2 |
0.728 | 0.249 | 1 | 0.917 |
AURC |
0.728 | 0.099 | -2 | 0.645 |
MST4 |
0.727 | 0.178 | 2 | 0.667 |
CLK1 |
0.726 | 0.194 | -3 | 0.745 |
PIM1 |
0.726 | 0.093 | -3 | 0.793 |
CDK4 |
0.726 | 0.326 | 1 | 0.915 |
NDR1 |
0.725 | 0.096 | -3 | 0.810 |
JNK1 |
0.725 | 0.314 | 1 | 0.913 |
CDK6 |
0.725 | 0.312 | 1 | 0.918 |
PRP4 |
0.725 | 0.239 | -3 | 0.770 |
ERK2 |
0.724 | 0.306 | 1 | 0.906 |
MPSK1 |
0.724 | 0.288 | 1 | 0.695 |
SRPK3 |
0.723 | 0.128 | -3 | 0.752 |
PRPK |
0.723 | 0.054 | -1 | 0.488 |
MAPKAPK2 |
0.723 | 0.087 | -3 | 0.754 |
P90RSK |
0.723 | 0.090 | -3 | 0.794 |
PKACB |
0.722 | 0.117 | -2 | 0.655 |
SKMLCK |
0.722 | 0.071 | -2 | 0.821 |
ATR |
0.721 | 0.046 | 1 | 0.663 |
RSK3 |
0.719 | 0.085 | -3 | 0.778 |
GRK7 |
0.719 | 0.094 | 1 | 0.643 |
PKCD |
0.719 | 0.092 | 2 | 0.508 |
PKCA |
0.719 | 0.116 | 2 | 0.483 |
PRKX |
0.718 | 0.103 | -3 | 0.700 |
PKACG |
0.717 | 0.067 | -2 | 0.723 |
CAMK1B |
0.717 | 0.013 | -3 | 0.822 |
LATS2 |
0.716 | 0.060 | -5 | 0.687 |
RSK4 |
0.716 | 0.082 | -3 | 0.767 |
CHAK2 |
0.715 | -0.008 | -1 | 0.425 |
PDHK4 |
0.715 | -0.002 | 1 | 0.660 |
MNK2 |
0.715 | 0.068 | -2 | 0.751 |
PKCB |
0.715 | 0.076 | 2 | 0.478 |
PKN3 |
0.715 | 0.018 | -3 | 0.812 |
GRK1 |
0.714 | 0.018 | -2 | 0.713 |
NEK6 |
0.714 | 0.008 | -2 | 0.751 |
CAMK2D |
0.713 | 0.037 | -3 | 0.805 |
LATS1 |
0.713 | 0.077 | -3 | 0.831 |
AKT2 |
0.713 | 0.101 | -3 | 0.714 |
P70S6KB |
0.712 | 0.046 | -3 | 0.779 |
WNK1 |
0.712 | 0.004 | -2 | 0.847 |
NIK |
0.712 | 0.015 | -3 | 0.822 |
CAMLCK |
0.712 | 0.028 | -2 | 0.783 |
GCN2 |
0.712 | -0.050 | 2 | 0.543 |
MAPKAPK3 |
0.711 | 0.021 | -3 | 0.774 |
PKCG |
0.711 | 0.066 | 2 | 0.468 |
PDHK1 |
0.711 | 0.020 | 1 | 0.625 |
AMPKA1 |
0.711 | 0.039 | -3 | 0.818 |
GRK5 |
0.711 | -0.049 | -3 | 0.789 |
TSSK1 |
0.711 | 0.074 | -3 | 0.835 |
NIM1 |
0.711 | 0.161 | 3 | 0.598 |
RAF1 |
0.711 | -0.054 | 1 | 0.595 |
NUAK2 |
0.710 | 0.040 | -3 | 0.822 |
PAK1 |
0.710 | 0.033 | -2 | 0.752 |
MARK4 |
0.710 | 0.087 | 4 | 0.728 |
MLK2 |
0.710 | 0.026 | 2 | 0.557 |
BMPR2 |
0.710 | -0.096 | -2 | 0.778 |
GSK3A |
0.710 | 0.124 | 4 | 0.383 |
PKCZ |
0.710 | 0.055 | 2 | 0.517 |
ERK7 |
0.710 | 0.102 | 2 | 0.366 |
ULK2 |
0.709 | -0.045 | 2 | 0.521 |
MASTL |
0.709 | 0.015 | -2 | 0.743 |
DAPK2 |
0.709 | 0.022 | -3 | 0.827 |
MNK1 |
0.709 | 0.045 | -2 | 0.752 |
SGK3 |
0.708 | 0.097 | -3 | 0.755 |
PKN2 |
0.707 | 0.008 | -3 | 0.796 |
CAMK2B |
0.707 | 0.013 | 2 | 0.492 |
TBK1 |
0.706 | -0.061 | 1 | 0.500 |
CAMK2G |
0.706 | -0.087 | 2 | 0.501 |
IKKA |
0.706 | 0.009 | -2 | 0.629 |
BCKDK |
0.706 | -0.000 | -1 | 0.475 |
CAMK2A |
0.706 | 0.006 | 2 | 0.489 |
IKKB |
0.706 | -0.089 | -2 | 0.634 |
DCAMKL1 |
0.706 | 0.086 | -3 | 0.781 |
AMPKA2 |
0.706 | 0.035 | -3 | 0.795 |
QSK |
0.705 | 0.101 | 4 | 0.706 |
PRKD3 |
0.705 | 0.051 | -3 | 0.748 |
MSK2 |
0.705 | 0.034 | -3 | 0.770 |
TGFBR2 |
0.704 | -0.026 | -2 | 0.691 |
MLK3 |
0.704 | -0.020 | 2 | 0.489 |
FAM20C |
0.704 | 0.006 | 2 | 0.395 |
DNAPK |
0.703 | 0.065 | 1 | 0.541 |
AURB |
0.703 | 0.039 | -2 | 0.633 |
PKR |
0.703 | 0.056 | 1 | 0.643 |
TGFBR1 |
0.703 | 0.024 | -2 | 0.709 |
PIM2 |
0.702 | 0.059 | -3 | 0.749 |
DSTYK |
0.702 | -0.106 | 2 | 0.570 |
MSK1 |
0.702 | 0.041 | -3 | 0.762 |
BMPR1B |
0.701 | 0.012 | 1 | 0.569 |
IRE1 |
0.701 | -0.031 | 1 | 0.608 |
TLK2 |
0.701 | 0.041 | 1 | 0.584 |
PKG2 |
0.700 | 0.036 | -2 | 0.669 |
PAK3 |
0.700 | -0.009 | -2 | 0.735 |
VRK2 |
0.700 | 0.116 | 1 | 0.711 |
PKACA |
0.700 | 0.075 | -2 | 0.616 |
NEK9 |
0.700 | -0.047 | 2 | 0.589 |
MLK1 |
0.699 | -0.109 | 2 | 0.543 |
TSSK2 |
0.699 | -0.043 | -5 | 0.808 |
IKKE |
0.699 | -0.093 | 1 | 0.489 |
SIK |
0.699 | 0.082 | -3 | 0.751 |
NEK7 |
0.698 | -0.112 | -3 | 0.772 |
MST3 |
0.698 | 0.102 | 2 | 0.585 |
ALK4 |
0.698 | -0.028 | -2 | 0.738 |
AKT3 |
0.698 | 0.097 | -3 | 0.678 |
AKT1 |
0.698 | 0.075 | -3 | 0.725 |
TAO3 |
0.697 | 0.107 | 1 | 0.589 |
RIPK3 |
0.697 | -0.112 | 3 | 0.583 |
SGK1 |
0.697 | 0.108 | -3 | 0.655 |
PHKG1 |
0.696 | -0.016 | -3 | 0.805 |
GRK6 |
0.696 | -0.097 | 1 | 0.625 |
PKCH |
0.696 | -0.002 | 2 | 0.465 |
ATM |
0.695 | -0.042 | 1 | 0.604 |
SMG1 |
0.695 | -0.029 | 1 | 0.630 |
AURA |
0.695 | 0.026 | -2 | 0.591 |
MELK |
0.694 | -0.014 | -3 | 0.774 |
PASK |
0.694 | 0.004 | -3 | 0.849 |
GRK4 |
0.694 | -0.107 | -2 | 0.718 |
HUNK |
0.694 | -0.123 | 2 | 0.531 |
PAK6 |
0.693 | 0.005 | -2 | 0.650 |
CK1E |
0.693 | 0.022 | -3 | 0.587 |
DLK |
0.693 | -0.156 | 1 | 0.601 |
CHK1 |
0.693 | -0.007 | -3 | 0.787 |
NEK2 |
0.693 | -0.035 | 2 | 0.563 |
RIPK1 |
0.693 | -0.099 | 1 | 0.595 |
ULK1 |
0.692 | -0.134 | -3 | 0.746 |
YSK4 |
0.691 | -0.070 | 1 | 0.536 |
SBK |
0.691 | 0.108 | -3 | 0.622 |
NUAK1 |
0.691 | -0.002 | -3 | 0.767 |
PKCE |
0.691 | 0.043 | 2 | 0.474 |
PAK2 |
0.691 | -0.035 | -2 | 0.730 |
PKCT |
0.691 | 0.034 | 2 | 0.477 |
QIK |
0.690 | 0.012 | -3 | 0.788 |
BUB1 |
0.690 | 0.078 | -5 | 0.769 |
MEK1 |
0.690 | -0.068 | 2 | 0.545 |
CAMK4 |
0.690 | -0.082 | -3 | 0.782 |
TTBK2 |
0.690 | -0.131 | 2 | 0.468 |
PBK |
0.690 | 0.116 | 1 | 0.673 |
IRE2 |
0.690 | -0.078 | 2 | 0.483 |
MLK4 |
0.690 | -0.081 | 2 | 0.470 |
WNK4 |
0.690 | 0.004 | -2 | 0.848 |
ALK2 |
0.689 | -0.029 | -2 | 0.705 |
ANKRD3 |
0.689 | -0.169 | 1 | 0.623 |
MARK3 |
0.689 | 0.039 | 4 | 0.649 |
LKB1 |
0.689 | 0.062 | -3 | 0.776 |
WNK3 |
0.689 | -0.175 | 1 | 0.595 |
GSK3B |
0.688 | 0.028 | 4 | 0.375 |
PINK1 |
0.687 | -0.008 | 1 | 0.785 |
PERK |
0.687 | -0.064 | -2 | 0.715 |
ROCK2 |
0.687 | 0.081 | -3 | 0.773 |
PLK4 |
0.686 | -0.004 | 2 | 0.385 |
NEK5 |
0.686 | -0.023 | 1 | 0.615 |
PKCI |
0.686 | 0.009 | 2 | 0.503 |
DCAMKL2 |
0.686 | -0.003 | -3 | 0.786 |
ACVR2A |
0.685 | -0.061 | -2 | 0.670 |
ACVR2B |
0.685 | -0.061 | -2 | 0.679 |
CHAK1 |
0.685 | -0.126 | 2 | 0.528 |
BRSK1 |
0.685 | -0.021 | -3 | 0.778 |
CK1D |
0.685 | 0.019 | -3 | 0.540 |
MEKK1 |
0.685 | -0.019 | 1 | 0.583 |
MEKK2 |
0.684 | -0.014 | 2 | 0.537 |
MYLK4 |
0.684 | -0.036 | -2 | 0.713 |
MEK5 |
0.684 | -0.073 | 2 | 0.545 |
GAK |
0.684 | 0.047 | 1 | 0.726 |
BRSK2 |
0.684 | -0.034 | -3 | 0.778 |
TNIK |
0.683 | 0.090 | 3 | 0.726 |
GCK |
0.683 | 0.074 | 1 | 0.562 |
P70S6K |
0.683 | 0.017 | -3 | 0.709 |
PDK1 |
0.682 | 0.039 | 1 | 0.593 |
CAMK1G |
0.682 | -0.032 | -3 | 0.756 |
PAK5 |
0.682 | 0.001 | -2 | 0.617 |
MARK2 |
0.682 | 0.014 | 4 | 0.617 |
ZAK |
0.681 | -0.073 | 1 | 0.535 |
KHS1 |
0.681 | 0.101 | 1 | 0.542 |
MAPKAPK5 |
0.680 | -0.054 | -3 | 0.735 |
CK1A2 |
0.680 | 0.005 | -3 | 0.542 |
BMPR1A |
0.680 | -0.020 | 1 | 0.546 |
KHS2 |
0.680 | 0.094 | 1 | 0.556 |
PAK4 |
0.680 | 0.002 | -2 | 0.619 |
BRAF |
0.679 | -0.086 | -4 | 0.570 |
MAP3K15 |
0.679 | 0.098 | 1 | 0.537 |
MRCKB |
0.679 | 0.048 | -3 | 0.726 |
IRAK4 |
0.679 | -0.086 | 1 | 0.588 |
HGK |
0.679 | 0.050 | 3 | 0.721 |
HPK1 |
0.678 | 0.055 | 1 | 0.544 |
GRK2 |
0.678 | -0.085 | -2 | 0.625 |
TAO2 |
0.678 | -0.003 | 2 | 0.564 |
DRAK1 |
0.678 | -0.106 | 1 | 0.539 |
CK1G1 |
0.677 | 0.011 | -3 | 0.569 |
MEKK6 |
0.677 | 0.054 | 1 | 0.564 |
CAMK1D |
0.676 | -0.005 | -3 | 0.695 |
EEF2K |
0.676 | -0.006 | 3 | 0.683 |
CRIK |
0.676 | 0.085 | -3 | 0.732 |
LRRK2 |
0.676 | 0.010 | 2 | 0.565 |
HRI |
0.676 | -0.151 | -2 | 0.736 |
SMMLCK |
0.675 | -0.036 | -3 | 0.790 |
MRCKA |
0.675 | 0.029 | -3 | 0.739 |
PLK1 |
0.675 | -0.173 | -2 | 0.668 |
DAPK3 |
0.675 | -0.005 | -3 | 0.795 |
NEK11 |
0.675 | -0.040 | 1 | 0.559 |
CK2A2 |
0.675 | -0.027 | 1 | 0.521 |
SSTK |
0.675 | -0.061 | 4 | 0.691 |
MARK1 |
0.674 | -0.015 | 4 | 0.673 |
LOK |
0.674 | 0.002 | -2 | 0.712 |
CAMKK2 |
0.674 | -0.040 | -2 | 0.643 |
MINK |
0.673 | 0.040 | 1 | 0.538 |
HASPIN |
0.673 | 0.005 | -1 | 0.366 |
DMPK1 |
0.673 | 0.056 | -3 | 0.751 |
PLK3 |
0.672 | -0.140 | 2 | 0.453 |
PKN1 |
0.672 | 0.001 | -3 | 0.725 |
YSK1 |
0.672 | 0.066 | 2 | 0.584 |
MEKK3 |
0.671 | -0.150 | 1 | 0.570 |
NEK1 |
0.671 | 0.014 | 1 | 0.580 |
NEK4 |
0.670 | -0.030 | 1 | 0.557 |
GRK3 |
0.670 | -0.066 | -2 | 0.588 |
PHKG2 |
0.669 | -0.063 | -3 | 0.757 |
MST2 |
0.669 | -0.048 | 1 | 0.564 |
SNRK |
0.669 | -0.148 | 2 | 0.397 |
TLK1 |
0.669 | -0.142 | -2 | 0.712 |
DAPK1 |
0.668 | -0.015 | -3 | 0.784 |
VRK1 |
0.667 | -0.047 | 2 | 0.537 |
CAMKK1 |
0.666 | -0.125 | -2 | 0.626 |
ROCK1 |
0.666 | 0.039 | -3 | 0.739 |
NEK8 |
0.666 | -0.158 | 2 | 0.538 |
SLK |
0.666 | -0.055 | -2 | 0.675 |
MYO3B |
0.666 | 0.067 | 2 | 0.577 |
CAMK1A |
0.666 | 0.002 | -3 | 0.678 |
CHK2 |
0.665 | 0.002 | -3 | 0.667 |
NEK3 |
0.664 | 0.038 | 1 | 0.536 |
CK2A1 |
0.664 | -0.038 | 1 | 0.498 |
OSR1 |
0.664 | 0.004 | 2 | 0.568 |
YANK3 |
0.663 | -0.022 | 2 | 0.241 |
STK33 |
0.663 | -0.099 | 2 | 0.385 |
BIKE |
0.661 | 0.047 | 1 | 0.684 |
AAK1 |
0.660 | 0.099 | 1 | 0.636 |
TAK1 |
0.660 | -0.131 | 1 | 0.572 |
PKG1 |
0.658 | -0.001 | -2 | 0.604 |
MST1 |
0.657 | -0.087 | 1 | 0.548 |
MEK2 |
0.657 | -0.077 | 2 | 0.546 |
PLK2 |
0.656 | -0.086 | -3 | 0.735 |
TTBK1 |
0.655 | -0.177 | 2 | 0.398 |
PDHK3_TYR |
0.654 | 0.242 | 4 | 0.827 |
TAO1 |
0.653 | -0.006 | 1 | 0.503 |
CK1A |
0.652 | -0.004 | -3 | 0.460 |
MYO3A |
0.652 | 0.008 | 1 | 0.562 |
IRAK1 |
0.650 | -0.246 | -1 | 0.356 |
ASK1 |
0.649 | -0.027 | 1 | 0.533 |
PKMYT1_TYR |
0.649 | 0.297 | 3 | 0.712 |
MAP2K4_TYR |
0.648 | 0.261 | -1 | 0.523 |
LIMK2_TYR |
0.647 | 0.183 | -3 | 0.817 |
TTK |
0.647 | -0.095 | -2 | 0.702 |
PDHK4_TYR |
0.643 | 0.098 | 2 | 0.553 |
TESK1_TYR |
0.642 | 0.081 | 3 | 0.740 |
ALPHAK3 |
0.642 | -0.102 | -1 | 0.420 |
MAP2K6_TYR |
0.641 | 0.102 | -1 | 0.511 |
PDHK1_TYR |
0.635 | 0.007 | -1 | 0.487 |
RIPK2 |
0.635 | -0.236 | 1 | 0.490 |
MAP2K7_TYR |
0.635 | 0.055 | 2 | 0.552 |
BMPR2_TYR |
0.632 | -0.007 | -1 | 0.508 |
LIMK1_TYR |
0.630 | 0.025 | 2 | 0.566 |
STLK3 |
0.628 | -0.131 | 1 | 0.510 |
PINK1_TYR |
0.627 | -0.107 | 1 | 0.673 |
YANK2 |
0.625 | -0.051 | 2 | 0.249 |
TNNI3K_TYR |
0.622 | 0.038 | 1 | 0.595 |
ABL2 |
0.620 | -0.047 | -1 | 0.386 |
RET |
0.620 | -0.116 | 1 | 0.607 |
ABL1 |
0.619 | -0.045 | -1 | 0.383 |
MST1R |
0.619 | -0.084 | 3 | 0.640 |
FGR |
0.618 | -0.083 | 1 | 0.652 |
JAK2 |
0.618 | -0.053 | 1 | 0.589 |
TNK1 |
0.618 | -0.009 | 3 | 0.622 |
TYK2 |
0.618 | -0.090 | 1 | 0.595 |
EPHB4 |
0.617 | -0.096 | -1 | 0.402 |
CK1G3 |
0.617 | -0.050 | -3 | 0.417 |
NEK10_TYR |
0.617 | 0.007 | 1 | 0.504 |
ROS1 |
0.615 | -0.090 | 3 | 0.592 |
YES1 |
0.615 | -0.073 | -1 | 0.415 |
EPHA6 |
0.615 | -0.128 | -1 | 0.425 |
TNK2 |
0.614 | -0.070 | 3 | 0.584 |
TXK |
0.613 | -0.056 | 1 | 0.595 |
CSF1R |
0.613 | -0.105 | 3 | 0.616 |
LCK |
0.613 | -0.061 | -1 | 0.392 |
TYRO3 |
0.611 | -0.156 | 3 | 0.630 |
JAK1 |
0.610 | -0.026 | 1 | 0.521 |
BLK |
0.609 | -0.060 | -1 | 0.395 |
JAK3 |
0.609 | -0.147 | 1 | 0.583 |
WEE1_TYR |
0.609 | -0.074 | -1 | 0.370 |
HCK |
0.609 | -0.113 | -1 | 0.391 |
DDR1 |
0.608 | -0.161 | 4 | 0.717 |
FGFR2 |
0.608 | -0.134 | 3 | 0.618 |
KDR |
0.607 | -0.113 | 3 | 0.573 |
EPHA4 |
0.606 | -0.115 | 2 | 0.457 |
FYN |
0.606 | -0.067 | -1 | 0.386 |
FER |
0.606 | -0.185 | 1 | 0.653 |
MET |
0.604 | -0.111 | 3 | 0.612 |
CK1G2 |
0.604 | -0.058 | -3 | 0.497 |
KIT |
0.602 | -0.155 | 3 | 0.619 |
EPHB3 |
0.602 | -0.150 | -1 | 0.377 |
FGFR1 |
0.602 | -0.131 | 3 | 0.580 |
INSRR |
0.601 | -0.177 | 3 | 0.561 |
PTK6 |
0.601 | -0.152 | -1 | 0.333 |
MERTK |
0.601 | -0.134 | 3 | 0.604 |
ITK |
0.601 | -0.148 | -1 | 0.366 |
SRMS |
0.600 | -0.179 | 1 | 0.612 |
EPHB2 |
0.600 | -0.153 | -1 | 0.376 |
PDGFRB |
0.599 | -0.199 | 3 | 0.622 |
FLT1 |
0.598 | -0.150 | -1 | 0.433 |
AXL |
0.598 | -0.163 | 3 | 0.594 |
TEK |
0.598 | -0.147 | 3 | 0.558 |
BMX |
0.597 | -0.123 | -1 | 0.312 |
SRC |
0.596 | -0.091 | -1 | 0.388 |
FLT3 |
0.596 | -0.198 | 3 | 0.623 |
PTK2 |
0.596 | -0.079 | -1 | 0.424 |
PDGFRA |
0.596 | -0.197 | 3 | 0.628 |
EPHB1 |
0.596 | -0.209 | 1 | 0.587 |
MATK |
0.595 | -0.109 | -1 | 0.349 |
FGFR3 |
0.595 | -0.152 | 3 | 0.584 |
DDR2 |
0.594 | -0.067 | 3 | 0.542 |
ERBB2 |
0.594 | -0.152 | 1 | 0.595 |
EGFR |
0.592 | -0.092 | 1 | 0.537 |
LYN |
0.592 | -0.138 | 3 | 0.560 |
EPHA7 |
0.592 | -0.145 | 2 | 0.456 |
EPHA3 |
0.592 | -0.170 | 2 | 0.435 |
LTK |
0.591 | -0.179 | 3 | 0.563 |
NTRK3 |
0.591 | -0.138 | -1 | 0.387 |
ALK |
0.591 | -0.187 | 3 | 0.529 |
SYK |
0.591 | -0.088 | -1 | 0.395 |
NTRK1 |
0.591 | -0.200 | -1 | 0.416 |
CSK |
0.590 | -0.125 | 2 | 0.464 |
EPHA1 |
0.589 | -0.158 | 3 | 0.582 |
FRK |
0.589 | -0.155 | -1 | 0.379 |
FGFR4 |
0.589 | -0.114 | -1 | 0.381 |
PTK2B |
0.589 | -0.129 | -1 | 0.341 |
ZAP70 |
0.589 | -0.031 | -1 | 0.371 |
INSR |
0.589 | -0.163 | 3 | 0.549 |
BTK |
0.588 | -0.239 | -1 | 0.332 |
FLT4 |
0.588 | -0.198 | 3 | 0.588 |
EPHA8 |
0.587 | -0.137 | -1 | 0.369 |
TEC |
0.586 | -0.196 | -1 | 0.311 |
EPHA5 |
0.585 | -0.167 | 2 | 0.426 |
NTRK2 |
0.583 | -0.232 | 3 | 0.576 |
MUSK |
0.582 | -0.120 | 1 | 0.540 |
ERBB4 |
0.577 | -0.093 | 1 | 0.558 |
EPHA2 |
0.576 | -0.150 | -1 | 0.357 |
IGF1R |
0.572 | -0.174 | 3 | 0.494 |
FES |
0.561 | -0.159 | -1 | 0.307 |