Motif 284 (n=145)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S41 | ochoa | Golgin A8 family member Q | None |
| A1L170 | C1orf226 | S47 | ochoa | Uncharacterized protein C1orf226 | None |
| A6NEQ0 | RBMY1E | S473 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NNA2 | SRRM3 | S447 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
| I6L899 | GOLGA8R | S41 | ochoa | Golgin subfamily A member 8R | None |
| O00267 | SUPT5H | S773 | ochoa|psp | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14686 | KMT2D | S3207 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15234 | CASC3 | S45 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15355 | PPM1G | T177 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15355 | PPM1G | S183 | ochoa|psp | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15417 | TNRC18 | S175 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43526 | KCNQ2 | S52 | psp | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| O75385 | ULK1 | S538 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75385 | ULK1 | S763 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75385 | ULK1 | S781 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O94913 | PCF11 | S794 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95049 | TJP3 | S159 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95278 | EPM2A | S25 | psp | Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) | Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:25538239, PubMed:25544560, PubMed:26231210). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:14722920, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). {ECO:0000250|UniProtKB:Q9WUA5, ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:16901901, ECO:0000269|PubMed:16971387, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:20453062, ECO:0000269|PubMed:22036712, ECO:0000269|PubMed:23624058, ECO:0000269|PubMed:23922729, ECO:0000269|PubMed:25538239, ECO:0000269|PubMed:25544560, ECO:0000269|PubMed:26231210}.; FUNCTION: [Isoform 2]: Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712). {ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}.; FUNCTION: [Isoform 7]: Has phosphatase activity (in vitro). {ECO:0000269|PubMed:22036712}. |
| P02452 | COL1A1 | S513 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S522 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S543 | ochoa|psp | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S546 | ochoa|psp | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S936 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | T948 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1023 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1029 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P02452 | COL1A1 | S1125 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P04626 | ERBB2 | S1083 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P07954 | FH | S365 | ochoa | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. |
| P08572 | COL4A2 | S1475 | ochoa | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. |
| P0C7P1 | RBMY1D | S473 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0DJD3 | RBMY1A1 | S473 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S473 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P12109 | COL6A1 | S348 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P12109 | COL6A1 | S387 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P17676 | CEBPB | S65 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P17844 | DDX5 | S24 | ochoa | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. |
| P19622 | EN2 | S148 | ochoa | Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2) | None |
| P21333 | FLNA | S1084 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25440 | BRD2 | T613 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27987 | ITPKB | S31 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P27987 | ITPKB | S447 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P29353 | SHC1 | S80 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P29353 | SHC1 | S139 | ochoa|psp | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P46531 | NOTCH1 | S2148 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P48382 | RFX5 | S505 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P54259 | ATN1 | S661 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| Q01804 | OTUD4 | S1049 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q01826 | SATB1 | S38 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q01955 | COL4A3 | S382 | ochoa | Collagen alpha-3(IV) chain (Goodpasture antigen) [Cleaved into: Tumstatin] | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. |
| Q02388 | COL7A1 | S2600 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q05707 | COL14A1 | S1543 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q05707 | COL14A1 | S1728 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q05707 | COL14A1 | S1734 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q06587 | RING1 | S163 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
| Q08357 | SLC20A2 | S321 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08357 | SLC20A2 | S324 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q09472 | EP300 | S255 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q10571 | MN1 | S1081 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q12852 | MAP3K12 | S555 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12852 | MAP3K12 | S634 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q12852 | MAP3K12 | S652 | ochoa | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) | Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074}. |
| Q13148 | TARDBP | S369 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q14055 | COL9A2 | S329 | ochoa | Collagen alpha-2(IX) chain | Structural component of hyaline cartilage and vitreous of the eye. |
| Q14151 | SAFB2 | S827 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14153 | FAM53B | S201 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14674 | ESPL1 | S1305 | psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q15027 | ACAP1 | S386 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}. |
| Q15056 | EIF4H | S30 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15424 | SAFB | S803 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15722 | LTB4R | S310 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q15744 | CEBPE | S112 | ochoa | CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) | Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269|PubMed:10359588, ECO:0000269|PubMed:26019275}. |
| Q15942 | ZYX | S290 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16763 | UBE2S | T175 | ochoa | Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| Q17RW2 | COL24A1 | T721 | ochoa | Collagen alpha-1(XXIV) chain | May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. {ECO:0000269|PubMed:12874293}. |
| Q32P44 | EML3 | S204 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q3ZCQ8 | TIMM50 | S45 | ochoa | Mitochondrial import inner membrane translocase subunit TIM50 | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:30190335, PubMed:38828998). Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:30190335, ECO:0000269|PubMed:38828998}.; FUNCTION: [Isoform 2]: May participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:16008839}. |
| Q5FWE3 | PRRT3 | S774 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5FWE3 | PRRT3 | S865 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JRA6 | MIA3 | S1666 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JSP0 | FGD3 | S56 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q66K74 | MAP1S | S478 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68CZ2 | TNS3 | S762 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6IN85 | PPP4R3A | S780 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6P996 | PDXDC1 | S695 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6ZNJ1 | NBEAL2 | S1367 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZNJ1 | NBEAL2 | S1376 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRI6 | C15orf39 | S322 | ochoa | Uncharacterized protein C15orf39 | None |
| Q7LBC6 | KDM3B | S314 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7LBC6 | KDM3B | S320 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q86U42 | PABPN1 | S90 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q86U42 | PABPN1 | S95 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q86VQ1 | GLCCI1 | S30 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86YV5 | PRAG1 | S889 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8NFW1 | COL22A1 | S962 | ochoa | Collagen alpha-1(XXII) chain | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
| Q8NFW1 | COL22A1 | S1061 | ochoa | Collagen alpha-1(XXII) chain | Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. |
| Q8NHG8 | ZNRF2 | S145 | ochoa|psp | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAP9 | MPLKIP | S47 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TAP9 | MPLKIP | S97 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8WWM7 | ATXN2L | S396 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WXE0 | CASKIN2 | S409 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WXE0 | CASKIN2 | S412 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WYP3 | RIN2 | S395 | ochoa | Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2) | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
| Q93052 | LPP | Y307 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969E4 | TCEAL3 | S65 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
| Q96C90 | PPP1R14B | S21 | ochoa | Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein) | Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}. |
| Q96MG7 | NSMCE3 | S60 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96NU1 | SAMD11 | S418 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96PE2 | ARHGEF17 | S138 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PE2 | ARHGEF17 | S717 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PV0 | SYNGAP1 | S895 | ochoa | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). {ECO:0000250}. |
| Q96QC0 | PPP1R10 | S552 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q99704 | DOK1 | S439 | ochoa|psp | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q99715 | COL12A1 | S2861 | ochoa | Collagen alpha-1(XII) chain | Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}. |
| Q99715 | COL12A1 | S2864 | ochoa | Collagen alpha-1(XII) chain | Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}. |
| Q9BQ61 | TRIR | S111 | ochoa | Telomerase RNA component interacting RNase (EC 3.1.13.-) (Exoribonuclease TRIR) | Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}. |
| Q9BXB5 | OSBPL10 | S322 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BXS0 | COL25A1 | S468 | ochoa | Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}. |
| Q9C0K0 | BCL11B | S775 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0W8 | SMG9 | S25 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H165 | BCL11A | S721 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H1J1 | UPF3A | S401 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H3P7 | ACBD3 | S47 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H4M7 | PLEKHA4 | S559 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H598 | SLC32A1 | S98 | ochoa | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT) | Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity). {ECO:0000250|UniProtKB:O35458, ECO:0000250|UniProtKB:O35633}. |
| Q9H6A9 | PCNX3 | S1947 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6K5 | PRR36 | S110 | ochoa | Proline-rich protein 36 | None |
| Q9H9D4 | ZNF408 | S345 | ochoa | Zinc finger protein 408 (PR domain zinc finger protein 17) | May be involved in transcriptional regulation. |
| Q9HC52 | CBX8 | S311 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCE6 | ARHGEF10L | S1256 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
| Q9NP98 | MYOZ1 | S167 | ochoa | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Q9NY59 | SMPD3 | S203 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NY59 | SMPD3 | S291 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NZB2 | FAM120A | S487 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9UHV7 | MED13 | S1033 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9ULC8 | ZDHHC8 | S664 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9UMN6 | KMT2B | S2146 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9Y2H5 | PLEKHA6 | S251 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2H5 | PLEKHA6 | S282 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2W1 | THRAP3 | S891 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y5B6 | PAXBP1 | S65 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6C2 | EMILIN1 | S839 | ochoa | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity. {ECO:0000269|PubMed:36351433}. |
| Q9Y6M5 | SLC30A1 | S172 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q13422 | IKZF1 | S101 | SIGNOR | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q9NQU5 | PAK6 | S224 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8948216 | Collagen chain trimerization | 1.619815e-13 | 12.791 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.305967e-11 | 10.275 |
| R-HSA-1474290 | Collagen formation | 1.378390e-09 | 8.861 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.982893e-09 | 8.223 |
| R-HSA-1442490 | Collagen degradation | 7.689803e-09 | 8.114 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.297684e-06 | 5.367 |
| R-HSA-2214320 | Anchoring fibril formation | 8.270775e-06 | 5.082 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.766689e-05 | 4.558 |
| R-HSA-1474244 | Extracellular matrix organization | 3.572377e-05 | 4.447 |
| R-HSA-1566977 | Fibronectin matrix formation | 3.058813e-05 | 4.514 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.338913e-05 | 4.198 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.338913e-05 | 4.198 |
| R-HSA-216083 | Integrin cell surface interactions | 8.552639e-05 | 4.068 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.402809e-04 | 3.619 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 3.339227e-04 | 3.476 |
| R-HSA-9842663 | Signaling by LTK | 3.339227e-04 | 3.476 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 3.981427e-04 | 3.400 |
| R-HSA-3000178 | ECM proteoglycans | 5.245511e-04 | 3.280 |
| R-HSA-419037 | NCAM1 interactions | 5.098265e-04 | 3.293 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 1.074470e-03 | 2.969 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.240494e-03 | 2.906 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.994149e-03 | 2.700 |
| R-HSA-3000157 | Laminin interactions | 2.221064e-03 | 2.653 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.226567e-03 | 2.652 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.501518e-03 | 2.602 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 2.573415e-03 | 2.589 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.774111e-03 | 2.557 |
| R-HSA-186797 | Signaling by PDGF | 2.774111e-03 | 2.557 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.376718e-03 | 2.472 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.217544e-03 | 2.375 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 4.502166e-03 | 2.347 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.804228e-03 | 2.318 |
| R-HSA-1266738 | Developmental Biology | 4.877331e-03 | 2.312 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 6.062877e-03 | 2.217 |
| R-HSA-8875878 | MET promotes cell motility | 6.252977e-03 | 2.204 |
| R-HSA-6806834 | Signaling by MET | 6.192375e-03 | 2.208 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 6.922919e-03 | 2.160 |
| R-HSA-201556 | Signaling by ALK | 6.639828e-03 | 2.178 |
| R-HSA-422475 | Axon guidance | 7.120966e-03 | 2.147 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 7.834878e-03 | 2.106 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 7.834878e-03 | 2.106 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 7.834878e-03 | 2.106 |
| R-HSA-9843745 | Adipogenesis | 7.542112e-03 | 2.123 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 9.583296e-03 | 2.018 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.258027e-03 | 2.033 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.087339e-02 | 1.964 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.087339e-02 | 1.964 |
| R-HSA-9634597 | GPER1 signaling | 1.129387e-02 | 1.947 |
| R-HSA-9675108 | Nervous system development | 1.109446e-02 | 1.955 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.198421e-02 | 1.921 |
| R-HSA-72187 | mRNA 3'-end processing | 1.356808e-02 | 1.867 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.314259e-02 | 1.881 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.314259e-02 | 1.881 |
| R-HSA-73887 | Death Receptor Signaling | 1.409319e-02 | 1.851 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.543252e-02 | 1.812 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.559871e-02 | 1.807 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 2.429401e-02 | 1.615 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 2.429401e-02 | 1.615 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.226113e-02 | 1.491 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.226113e-02 | 1.491 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.226113e-02 | 1.491 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 3.226113e-02 | 1.491 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.226113e-02 | 1.491 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.226113e-02 | 1.491 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.226113e-02 | 1.491 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.226113e-02 | 1.491 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.226113e-02 | 1.491 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 3.226113e-02 | 1.491 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.226113e-02 | 1.491 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.226113e-02 | 1.491 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.226113e-02 | 1.491 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.823517e-02 | 1.739 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.961901e-02 | 1.707 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.104553e-02 | 1.677 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.251397e-02 | 1.648 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.557351e-02 | 1.592 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.557351e-02 | 1.592 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 3.045825e-02 | 1.516 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.390316e-02 | 1.470 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.568001e-02 | 1.448 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.952938e-02 | 1.709 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.952938e-02 | 1.709 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 2.429401e-02 | 1.615 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 3.390316e-02 | 1.470 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.957450e-02 | 1.708 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.004301e-02 | 1.698 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.957450e-02 | 1.708 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.510811e-02 | 1.600 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.557351e-02 | 1.592 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.185339e-02 | 1.660 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.264391e-02 | 1.645 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.104553e-02 | 1.677 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.879160e-02 | 1.541 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.884572e-02 | 1.725 |
| R-HSA-2559583 | Cellular Senescence | 2.459875e-02 | 1.609 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.390316e-02 | 1.470 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.568001e-02 | 1.448 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.716311e-02 | 1.566 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.716311e-02 | 1.566 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 2.879160e-02 | 1.541 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.608449e-02 | 1.794 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.961901e-02 | 1.707 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.045825e-02 | 1.516 |
| R-HSA-162582 | Signal Transduction | 3.288399e-02 | 1.483 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.139702e-02 | 1.503 |
| R-HSA-4839726 | Chromatin organization | 2.403120e-02 | 1.619 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.216234e-02 | 1.493 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.879160e-02 | 1.541 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.432190e-02 | 1.464 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.952341e-02 | 1.530 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.749218e-02 | 1.426 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.843387e-02 | 1.415 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 4.016369e-02 | 1.396 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 4.016369e-02 | 1.396 |
| R-HSA-8875513 | MET interacts with TNS proteins | 4.016369e-02 | 1.396 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.800219e-02 | 1.319 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 4.800219e-02 | 1.319 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 4.800219e-02 | 1.319 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 4.800219e-02 | 1.319 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 4.800219e-02 | 1.319 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 4.800219e-02 | 1.319 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 5.577717e-02 | 1.254 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 5.577717e-02 | 1.254 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 5.577717e-02 | 1.254 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.387577e-02 | 1.269 |
| R-HSA-8853659 | RET signaling | 4.906940e-02 | 1.309 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 4.800219e-02 | 1.319 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.705934e-02 | 1.327 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 5.577717e-02 | 1.254 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 4.705934e-02 | 1.327 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 4.705934e-02 | 1.327 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.956795e-02 | 1.225 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 5.577717e-02 | 1.254 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.956795e-02 | 1.225 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.275531e-02 | 1.278 |
| R-HSA-166520 | Signaling by NTRKs | 4.848177e-02 | 1.314 |
| R-HSA-9931953 | Biofilm formation | 5.318103e-02 | 1.274 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.906940e-02 | 1.309 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.985058e-02 | 1.223 |
| R-HSA-8939211 | ESR-mediated signaling | 6.126979e-02 | 1.213 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 6.175303e-02 | 1.209 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.251379e-02 | 1.204 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 6.348912e-02 | 1.197 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 6.348912e-02 | 1.197 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 6.348912e-02 | 1.197 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 6.348912e-02 | 1.197 |
| R-HSA-157118 | Signaling by NOTCH | 6.372008e-02 | 1.196 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 6.396518e-02 | 1.194 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.523143e-02 | 1.186 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.620382e-02 | 1.179 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.747374e-02 | 1.171 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 7.872598e-02 | 1.104 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 8.625190e-02 | 1.064 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 9.371680e-02 | 1.028 |
| R-HSA-9700645 | ALK mutants bind TKIs | 9.371680e-02 | 1.028 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.229760e-01 | 0.910 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.229760e-01 | 0.910 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.372520e-01 | 0.862 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.443033e-01 | 0.841 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.443033e-01 | 0.841 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.512974e-01 | 0.820 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.512974e-01 | 0.820 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.582348e-01 | 0.801 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.582348e-01 | 0.801 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.651159e-01 | 0.782 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.787110e-01 | 0.748 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.787110e-01 | 0.748 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 1.787110e-01 | 0.748 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.920865e-01 | 0.717 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.117453e-01 | 0.674 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.077867e-01 | 0.967 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.077867e-01 | 0.967 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.077867e-01 | 0.967 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.077867e-01 | 0.967 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.077867e-01 | 0.967 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.319755e-01 | 0.880 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.515576e-01 | 0.819 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 8.016035e-02 | 1.096 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.085742e-01 | 0.964 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.085742e-01 | 0.964 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.229760e-01 | 0.910 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 1.301431e-01 | 0.886 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.443033e-01 | 0.841 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.085742e-01 | 0.964 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.651159e-01 | 0.782 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.001573e-01 | 0.999 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.157503e-01 | 0.936 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.157503e-01 | 0.936 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.582348e-01 | 0.801 |
| R-HSA-167044 | Signalling to RAS | 1.920865e-01 | 0.717 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.052457e-01 | 0.688 |
| R-HSA-1268020 | Mitochondrial protein import | 1.130524e-01 | 0.947 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.402951e-01 | 0.853 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.621851e-01 | 0.790 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.229760e-01 | 0.910 |
| R-HSA-74749 | Signal attenuation | 1.011212e-01 | 0.995 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.854260e-01 | 0.732 |
| R-HSA-9824272 | Somitogenesis | 7.075827e-02 | 1.150 |
| R-HSA-8851805 | MET activates RAS signaling | 1.229760e-01 | 0.910 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.117453e-01 | 0.674 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.229760e-01 | 0.910 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.582348e-01 | 0.801 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.719412e-01 | 0.765 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 1.854260e-01 | 0.732 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.011212e-01 | 0.995 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.582348e-01 | 0.801 |
| R-HSA-3322077 | Glycogen synthesis | 1.854260e-01 | 0.732 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.034487e-01 | 0.692 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 8.625190e-02 | 1.064 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 9.371680e-02 | 1.028 |
| R-HSA-428540 | Activation of RAC1 | 1.157503e-01 | 0.936 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.229760e-01 | 0.910 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.301431e-01 | 0.886 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.025900e-01 | 0.989 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.229760e-01 | 0.910 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.651159e-01 | 0.782 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.651159e-01 | 0.782 |
| R-HSA-9671793 | Diseases of hemostasis | 1.787110e-01 | 0.748 |
| R-HSA-391906 | Leukotriene receptors | 7.113856e-02 | 1.148 |
| R-HSA-3229121 | Glycogen storage diseases | 1.651159e-01 | 0.782 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.719412e-01 | 0.765 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.117453e-01 | 0.674 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.117453e-01 | 0.674 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.582348e-01 | 0.801 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.833501e-01 | 0.737 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.920865e-01 | 0.717 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.920865e-01 | 0.717 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.582348e-01 | 0.801 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.034913e-01 | 0.985 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 7.075827e-02 | 1.150 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.443033e-01 | 0.841 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.719412e-01 | 0.765 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 1.487249e-01 | 0.828 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.068678e-01 | 0.684 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.920865e-01 | 0.717 |
| R-HSA-74160 | Gene expression (Transcription) | 1.967462e-01 | 0.706 |
| R-HSA-8963896 | HDL assembly | 1.372520e-01 | 0.862 |
| R-HSA-9758941 | Gastrulation | 1.582576e-01 | 0.801 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.084655e-01 | 0.965 |
| R-HSA-1989781 | PPARA activates gene expression | 1.701278e-01 | 0.769 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.804181e-01 | 0.744 |
| R-HSA-5654741 | Signaling by FGFR3 | 7.075827e-02 | 1.150 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.443033e-01 | 0.841 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.629923e-01 | 0.788 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.741411e-01 | 0.759 |
| R-HSA-212436 | Generic Transcription Pathway | 1.456422e-01 | 0.837 |
| R-HSA-5654736 | Signaling by FGFR1 | 9.746602e-02 | 1.011 |
| R-HSA-435354 | Zinc transporters | 1.372520e-01 | 0.862 |
| R-HSA-8848021 | Signaling by PTK6 | 1.157101e-01 | 0.937 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.157101e-01 | 0.937 |
| R-HSA-210993 | Tie2 Signaling | 1.719412e-01 | 0.765 |
| R-HSA-418555 | G alpha (s) signalling events | 2.050356e-01 | 0.688 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.566080e-01 | 0.805 |
| R-HSA-8983711 | OAS antiviral response | 1.229760e-01 | 0.910 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 1.854260e-01 | 0.732 |
| R-HSA-3000170 | Syndecan interactions | 2.117453e-01 | 0.674 |
| R-HSA-6807070 | PTEN Regulation | 1.372229e-01 | 0.863 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.459034e-01 | 0.836 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.301431e-01 | 0.886 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.651159e-01 | 0.782 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.113207e-01 | 0.953 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.372520e-01 | 0.862 |
| R-HSA-186712 | Regulation of beta-cell development | 1.051795e-01 | 0.978 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.192355e-01 | 0.924 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 1.787110e-01 | 0.748 |
| R-HSA-75893 | TNF signaling | 9.746602e-02 | 1.011 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.130524e-01 | 0.947 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.981098e-01 | 0.703 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.842027e-01 | 0.735 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.833501e-01 | 0.737 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.372229e-01 | 0.863 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.010797e-01 | 0.697 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.181921e-01 | 0.661 |
| R-HSA-9865881 | Complex III assembly | 2.181921e-01 | 0.661 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.181921e-01 | 0.661 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.222155e-01 | 0.653 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.245867e-01 | 0.649 |
| R-HSA-9839394 | TGFBR3 expression | 2.245867e-01 | 0.649 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.245867e-01 | 0.649 |
| R-HSA-3214842 | HDMs demethylate histones | 2.245867e-01 | 0.649 |
| R-HSA-190236 | Signaling by FGFR | 2.250054e-01 | 0.648 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.308958e-01 | 0.637 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.309293e-01 | 0.637 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.309293e-01 | 0.637 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.309293e-01 | 0.637 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.370521e-01 | 0.625 |
| R-HSA-1483255 | PI Metabolism | 2.370521e-01 | 0.625 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.372204e-01 | 0.625 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.372204e-01 | 0.625 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.372204e-01 | 0.625 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.372204e-01 | 0.625 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.430895e-01 | 0.614 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.434605e-01 | 0.614 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.434605e-01 | 0.614 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.434605e-01 | 0.614 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.434605e-01 | 0.614 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.434605e-01 | 0.614 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.461108e-01 | 0.609 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.461108e-01 | 0.609 |
| R-HSA-9833110 | RSV-host interactions | 2.461108e-01 | 0.609 |
| R-HSA-72086 | mRNA Capping | 2.496498e-01 | 0.603 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.496498e-01 | 0.603 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.496498e-01 | 0.603 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.557890e-01 | 0.592 |
| R-HSA-2424491 | DAP12 signaling | 2.557890e-01 | 0.592 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.557890e-01 | 0.592 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.557890e-01 | 0.592 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.557890e-01 | 0.592 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 2.582088e-01 | 0.588 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.592071e-01 | 0.586 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.618783e-01 | 0.582 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.618783e-01 | 0.582 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.679181e-01 | 0.572 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.679181e-01 | 0.572 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.739089e-01 | 0.562 |
| R-HSA-9930044 | Nuclear RNA decay | 2.739089e-01 | 0.562 |
| R-HSA-354192 | Integrin signaling | 2.739089e-01 | 0.562 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.739089e-01 | 0.562 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.743411e-01 | 0.562 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.798510e-01 | 0.553 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.857449e-01 | 0.544 |
| R-HSA-1980145 | Signaling by NOTCH2 | 2.857449e-01 | 0.544 |
| R-HSA-5205647 | Mitophagy | 2.857449e-01 | 0.544 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.914895e-01 | 0.535 |
| R-HSA-187687 | Signalling to ERKs | 2.915908e-01 | 0.535 |
| R-HSA-381042 | PERK regulates gene expression | 2.915908e-01 | 0.535 |
| R-HSA-114604 | GPVI-mediated activation cascade | 2.973893e-01 | 0.527 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.975279e-01 | 0.526 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.031407e-01 | 0.518 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.031407e-01 | 0.518 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.031407e-01 | 0.518 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.031407e-01 | 0.518 |
| R-HSA-1566948 | Elastic fibre formation | 3.088454e-01 | 0.510 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.088454e-01 | 0.510 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.101924e-01 | 0.508 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.145037e-01 | 0.502 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.145037e-01 | 0.502 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.145037e-01 | 0.502 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.145037e-01 | 0.502 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.201161e-01 | 0.495 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.201161e-01 | 0.495 |
| R-HSA-167169 | HIV Transcription Elongation | 3.201161e-01 | 0.495 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.201161e-01 | 0.495 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3.201161e-01 | 0.495 |
| R-HSA-3371568 | Attenuation phase | 3.201161e-01 | 0.495 |
| R-HSA-8982491 | Glycogen metabolism | 3.201161e-01 | 0.495 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.201161e-01 | 0.495 |
| R-HSA-114608 | Platelet degranulation | 3.245889e-01 | 0.489 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.256828e-01 | 0.487 |
| R-HSA-9694548 | Maturation of spike protein | 3.256828e-01 | 0.487 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.275813e-01 | 0.485 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.312043e-01 | 0.480 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.366809e-01 | 0.473 |
| R-HSA-8854214 | TBC/RABGAPs | 3.421130e-01 | 0.466 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.453709e-01 | 0.462 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.454578e-01 | 0.462 |
| R-HSA-2262752 | Cellular responses to stress | 3.470449e-01 | 0.460 |
| R-HSA-2172127 | DAP12 interactions | 3.475010e-01 | 0.459 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.572921e-01 | 0.447 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.581459e-01 | 0.446 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.581459e-01 | 0.446 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.581459e-01 | 0.446 |
| R-HSA-75153 | Apoptotic execution phase | 3.581459e-01 | 0.446 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.602391e-01 | 0.443 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.634036e-01 | 0.440 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.686185e-01 | 0.433 |
| R-HSA-425410 | Metal ion SLC transporters | 3.686185e-01 | 0.433 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.789214e-01 | 0.421 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.840101e-01 | 0.416 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.890575e-01 | 0.410 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.890575e-01 | 0.410 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.923091e-01 | 0.406 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.940638e-01 | 0.404 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.940638e-01 | 0.404 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.940638e-01 | 0.404 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.940638e-01 | 0.404 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.940638e-01 | 0.404 |
| R-HSA-72649 | Translation initiation complex formation | 3.990294e-01 | 0.399 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.990294e-01 | 0.399 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 4.009342e-01 | 0.397 |
| R-HSA-8953854 | Metabolism of RNA | 4.038262e-01 | 0.394 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.039546e-01 | 0.394 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.066527e-01 | 0.391 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.066527e-01 | 0.391 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.088397e-01 | 0.388 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.088397e-01 | 0.388 |
| R-HSA-177929 | Signaling by EGFR | 4.088397e-01 | 0.388 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.088397e-01 | 0.388 |
| R-HSA-9609507 | Protein localization | 4.095023e-01 | 0.388 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.136851e-01 | 0.383 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.184911e-01 | 0.378 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.184911e-01 | 0.378 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.184911e-01 | 0.378 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.208709e-01 | 0.376 |
| R-HSA-9711097 | Cellular response to starvation | 4.236500e-01 | 0.373 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.373272e-01 | 0.359 |
| R-HSA-9707616 | Heme signaling | 4.373272e-01 | 0.359 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.403963e-01 | 0.356 |
| R-HSA-373755 | Semaphorin interactions | 4.419408e-01 | 0.355 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.465169e-01 | 0.350 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.510557e-01 | 0.346 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.555576e-01 | 0.341 |
| R-HSA-167172 | Transcription of the HIV genome | 4.644517e-01 | 0.333 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.730774e-01 | 0.325 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.732017e-01 | 0.325 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 4.732017e-01 | 0.325 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.732017e-01 | 0.325 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.775233e-01 | 0.321 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.775233e-01 | 0.321 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.775233e-01 | 0.321 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.775233e-01 | 0.321 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.775233e-01 | 0.321 |
| R-HSA-388396 | GPCR downstream signalling | 4.781713e-01 | 0.320 |
| R-HSA-1483257 | Phospholipid metabolism | 4.785232e-01 | 0.320 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.818097e-01 | 0.317 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.818097e-01 | 0.317 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.860613e-01 | 0.313 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.860613e-01 | 0.313 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 4.860613e-01 | 0.313 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.884074e-01 | 0.311 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.902782e-01 | 0.310 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.902782e-01 | 0.310 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.942251e-01 | 0.306 |
| R-HSA-8852135 | Protein ubiquitination | 4.944607e-01 | 0.306 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.027240e-01 | 0.299 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.027240e-01 | 0.299 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.068052e-01 | 0.295 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.224204e-01 | 0.282 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.226186e-01 | 0.282 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.228002e-01 | 0.282 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.422622e-01 | 0.266 |
| R-HSA-9640148 | Infection with Enterobacteria | 5.447023e-01 | 0.264 |
| R-HSA-72172 | mRNA Splicing | 5.495558e-01 | 0.260 |
| R-HSA-9663891 | Selective autophagy | 5.495624e-01 | 0.260 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.569314e-01 | 0.254 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.677611e-01 | 0.246 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 5.677611e-01 | 0.246 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.677611e-01 | 0.246 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.713123e-01 | 0.243 |
| R-HSA-1643685 | Disease | 5.714554e-01 | 0.243 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.748345e-01 | 0.240 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.748345e-01 | 0.240 |
| R-HSA-68882 | Mitotic Anaphase | 5.779165e-01 | 0.238 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.783280e-01 | 0.238 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.802207e-01 | 0.236 |
| R-HSA-372790 | Signaling by GPCR | 5.841050e-01 | 0.234 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.852298e-01 | 0.233 |
| R-HSA-1296071 | Potassium Channels | 5.852298e-01 | 0.233 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.886385e-01 | 0.230 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.920195e-01 | 0.228 |
| R-HSA-9614085 | FOXO-mediated transcription | 5.953728e-01 | 0.225 |
| R-HSA-3214847 | HATs acetylate histones | 5.953728e-01 | 0.225 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 5.986988e-01 | 0.223 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.149261e-01 | 0.211 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.212332e-01 | 0.207 |
| R-HSA-69239 | Synthesis of DNA | 6.243482e-01 | 0.205 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 6.243829e-01 | 0.205 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.274377e-01 | 0.202 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.274377e-01 | 0.202 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.305021e-01 | 0.200 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.395458e-01 | 0.194 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.395458e-01 | 0.194 |
| R-HSA-199991 | Membrane Trafficking | 6.449118e-01 | 0.190 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.483698e-01 | 0.188 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.541330e-01 | 0.184 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.569794e-01 | 0.182 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.569794e-01 | 0.182 |
| R-HSA-373760 | L1CAM interactions | 6.569794e-01 | 0.182 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.626025e-01 | 0.179 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 6.689118e-01 | 0.175 |
| R-HSA-3371556 | Cellular response to heat stress | 6.708662e-01 | 0.173 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.762634e-01 | 0.170 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 6.762634e-01 | 0.170 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.969878e-01 | 0.157 |
| R-HSA-446728 | Cell junction organization | 7.036141e-01 | 0.153 |
| R-HSA-9909396 | Circadian clock | 7.044152e-01 | 0.152 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.105560e-01 | 0.148 |
| R-HSA-1632852 | Macroautophagy | 7.278925e-01 | 0.138 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.323610e-01 | 0.135 |
| R-HSA-195721 | Signaling by WNT | 7.369860e-01 | 0.133 |
| R-HSA-69242 | S Phase | 7.453340e-01 | 0.128 |
| R-HSA-69306 | DNA Replication | 7.556667e-01 | 0.122 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.576828e-01 | 0.121 |
| R-HSA-9612973 | Autophagy | 7.616655e-01 | 0.118 |
| R-HSA-162587 | HIV Life Cycle | 7.636324e-01 | 0.117 |
| R-HSA-1500931 | Cell-Cell communication | 7.642548e-01 | 0.117 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.694370e-01 | 0.114 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.694370e-01 | 0.114 |
| R-HSA-109581 | Apoptosis | 7.732280e-01 | 0.112 |
| R-HSA-5619102 | SLC transporter disorders | 7.824368e-01 | 0.107 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.912744e-01 | 0.102 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.929987e-01 | 0.101 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.980707e-01 | 0.098 |
| R-HSA-611105 | Respiratory electron transport | 8.030516e-01 | 0.095 |
| R-HSA-168255 | Influenza Infection | 8.046793e-01 | 0.094 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.079561e-01 | 0.093 |
| R-HSA-3781865 | Diseases of glycosylation | 8.126198e-01 | 0.090 |
| R-HSA-69275 | G2/M Transition | 8.157055e-01 | 0.088 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.187408e-01 | 0.087 |
| R-HSA-597592 | Post-translational protein modification | 8.232322e-01 | 0.084 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.359383e-01 | 0.078 |
| R-HSA-428157 | Sphingolipid metabolism | 8.372961e-01 | 0.077 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.399783e-01 | 0.076 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.399783e-01 | 0.076 |
| R-HSA-5357801 | Programmed Cell Death | 8.439195e-01 | 0.074 |
| R-HSA-68886 | M Phase | 8.453493e-01 | 0.073 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.463428e-01 | 0.072 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.531375e-01 | 0.069 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.539648e-01 | 0.069 |
| R-HSA-9679506 | SARS-CoV Infections | 8.547354e-01 | 0.068 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.634458e-01 | 0.064 |
| R-HSA-162906 | HIV Infection | 8.700239e-01 | 0.060 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.721702e-01 | 0.059 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.808613e-01 | 0.055 |
| R-HSA-5668914 | Diseases of metabolism | 8.847330e-01 | 0.053 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.899707e-01 | 0.051 |
| R-HSA-5688426 | Deubiquitination | 8.970703e-01 | 0.047 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.979251e-01 | 0.047 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.996138e-01 | 0.046 |
| R-HSA-109582 | Hemostasis | 9.006924e-01 | 0.045 |
| R-HSA-416476 | G alpha (q) signalling events | 9.045151e-01 | 0.044 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.105821e-01 | 0.041 |
| R-HSA-112316 | Neuronal System | 9.123748e-01 | 0.040 |
| R-HSA-9824446 | Viral Infection Pathways | 9.150666e-01 | 0.039 |
| R-HSA-1640170 | Cell Cycle | 9.410249e-01 | 0.026 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.416926e-01 | 0.026 |
| R-HSA-913531 | Interferon Signaling | 9.650533e-01 | 0.015 |
| R-HSA-382551 | Transport of small molecules | 9.673622e-01 | 0.014 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.681416e-01 | 0.014 |
| R-HSA-556833 | Metabolism of lipids | 9.689864e-01 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 9.702211e-01 | 0.013 |
| R-HSA-5663205 | Infectious disease | 9.752108e-01 | 0.011 |
| R-HSA-72766 | Translation | 9.762762e-01 | 0.010 |
| R-HSA-1280218 | Adaptive Immune System | 9.779481e-01 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.809505e-01 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 9.812696e-01 | 0.008 |
| R-HSA-500792 | GPCR ligand binding | 9.938879e-01 | 0.003 |
| R-HSA-449147 | Signaling by Interleukins | 9.955040e-01 | 0.002 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.990239e-01 | 0.000 |
| R-HSA-168249 | Innate Immune System | 9.991828e-01 | 0.000 |
| R-HSA-168256 | Immune System | 9.999661e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999984e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.768 | 0.336 | 1 | 0.822 |
CLK3 |
0.765 | 0.219 | 1 | 0.861 |
HIPK4 |
0.765 | 0.293 | 1 | 0.855 |
HIPK2 |
0.764 | 0.296 | 1 | 0.830 |
CDK7 |
0.759 | 0.272 | 1 | 0.851 |
KIS |
0.759 | 0.257 | 1 | 0.858 |
CDK19 |
0.758 | 0.311 | 1 | 0.814 |
CDK5 |
0.756 | 0.312 | 1 | 0.860 |
CDK8 |
0.754 | 0.290 | 1 | 0.829 |
CDK17 |
0.753 | 0.295 | 1 | 0.782 |
NDR2 |
0.753 | 0.196 | -3 | 0.779 |
MAK |
0.751 | 0.342 | -2 | 0.897 |
SRPK1 |
0.750 | 0.152 | -3 | 0.718 |
HIPK1 |
0.750 | 0.269 | 1 | 0.876 |
CDK13 |
0.750 | 0.260 | 1 | 0.837 |
CDK16 |
0.750 | 0.299 | 1 | 0.796 |
MTOR |
0.749 | 0.364 | 1 | 0.720 |
CDKL5 |
0.749 | 0.198 | -3 | 0.737 |
CDK1 |
0.749 | 0.262 | 1 | 0.830 |
DYRK2 |
0.749 | 0.260 | 1 | 0.865 |
CDK12 |
0.748 | 0.269 | 1 | 0.818 |
CDK3 |
0.747 | 0.256 | 1 | 0.800 |
P38B |
0.746 | 0.303 | 1 | 0.820 |
P38G |
0.746 | 0.275 | 1 | 0.778 |
ICK |
0.746 | 0.256 | -3 | 0.776 |
ERK1 |
0.746 | 0.276 | 1 | 0.817 |
PIM3 |
0.745 | 0.096 | -3 | 0.784 |
COT |
0.745 | 0.100 | 2 | 0.698 |
P38A |
0.745 | 0.315 | 1 | 0.854 |
CDKL1 |
0.745 | 0.196 | -3 | 0.742 |
CDK10 |
0.742 | 0.253 | 1 | 0.840 |
CDK14 |
0.741 | 0.286 | 1 | 0.842 |
NLK |
0.741 | 0.193 | 1 | 0.868 |
CDK9 |
0.740 | 0.241 | 1 | 0.840 |
CDC7 |
0.740 | 0.100 | 1 | 0.742 |
CLK2 |
0.740 | 0.190 | -3 | 0.708 |
JNK2 |
0.739 | 0.263 | 1 | 0.816 |
MOS |
0.739 | 0.101 | 1 | 0.785 |
PRKD1 |
0.738 | 0.131 | -3 | 0.777 |
ERK5 |
0.737 | 0.143 | 1 | 0.821 |
DYRK1A |
0.737 | 0.231 | 1 | 0.861 |
MST4 |
0.736 | 0.193 | 2 | 0.809 |
P38D |
0.735 | 0.257 | 1 | 0.802 |
SRPK2 |
0.734 | 0.108 | -3 | 0.642 |
NDR1 |
0.734 | 0.095 | -3 | 0.757 |
PIM1 |
0.733 | 0.082 | -3 | 0.720 |
HIPK3 |
0.732 | 0.230 | 1 | 0.848 |
DYRK4 |
0.732 | 0.239 | 1 | 0.834 |
MOK |
0.732 | 0.267 | 1 | 0.866 |
DYRK1B |
0.732 | 0.224 | 1 | 0.843 |
PRPK |
0.731 | 0.078 | -1 | 0.203 |
JNK3 |
0.730 | 0.232 | 1 | 0.832 |
PKCA |
0.730 | 0.165 | 2 | 0.643 |
PRKD2 |
0.730 | 0.071 | -3 | 0.718 |
PKCD |
0.730 | 0.124 | 2 | 0.674 |
RSK2 |
0.730 | 0.069 | -3 | 0.722 |
PRP4 |
0.729 | 0.211 | -3 | 0.797 |
P90RSK |
0.729 | 0.071 | -3 | 0.733 |
PKCB |
0.728 | 0.115 | 2 | 0.644 |
NIM1 |
0.728 | 0.281 | 3 | 0.742 |
AURC |
0.727 | 0.049 | -2 | 0.590 |
SKMLCK |
0.727 | 0.059 | -2 | 0.822 |
MPSK1 |
0.727 | 0.320 | 1 | 0.743 |
MARK4 |
0.726 | 0.181 | 4 | 0.818 |
CLK4 |
0.726 | 0.118 | -3 | 0.705 |
ATR |
0.726 | 0.061 | 1 | 0.739 |
ERK2 |
0.725 | 0.205 | 1 | 0.837 |
DYRK3 |
0.725 | 0.182 | 1 | 0.866 |
CLK1 |
0.724 | 0.124 | -3 | 0.681 |
PKCG |
0.724 | 0.116 | 2 | 0.636 |
SRPK3 |
0.724 | 0.094 | -3 | 0.682 |
CHAK2 |
0.724 | -0.002 | -1 | 0.134 |
NUAK2 |
0.724 | 0.066 | -3 | 0.761 |
LATS2 |
0.723 | 0.041 | -5 | 0.698 |
RSK3 |
0.723 | 0.064 | -3 | 0.722 |
RAF1 |
0.723 | -0.017 | 1 | 0.690 |
CDK6 |
0.722 | 0.230 | 1 | 0.832 |
CDK2 |
0.721 | 0.170 | 1 | 0.848 |
NEK6 |
0.721 | -0.018 | -2 | 0.805 |
MLK2 |
0.721 | 0.045 | 2 | 0.708 |
PKACB |
0.721 | 0.082 | -2 | 0.614 |
WNK1 |
0.721 | 0.020 | -2 | 0.858 |
PKCZ |
0.721 | 0.078 | 2 | 0.663 |
MLK3 |
0.720 | 0.024 | 2 | 0.657 |
PDHK4 |
0.720 | -0.010 | 1 | 0.729 |
GCN2 |
0.720 | -0.048 | 2 | 0.683 |
QSK |
0.720 | 0.167 | 4 | 0.799 |
CDK4 |
0.720 | 0.228 | 1 | 0.814 |
BMPR2 |
0.719 | -0.077 | -2 | 0.834 |
NIK |
0.719 | 0.035 | -3 | 0.780 |
RSK4 |
0.719 | 0.064 | -3 | 0.702 |
AMPKA1 |
0.719 | 0.062 | -3 | 0.768 |
PKN3 |
0.718 | 0.016 | -3 | 0.754 |
MNK2 |
0.718 | 0.043 | -2 | 0.746 |
CAMK1B |
0.717 | -0.015 | -3 | 0.770 |
TBK1 |
0.717 | -0.032 | 1 | 0.573 |
ULK2 |
0.717 | -0.031 | 2 | 0.643 |
PKACG |
0.717 | 0.037 | -2 | 0.692 |
GRK7 |
0.717 | 0.090 | 1 | 0.661 |
PDHK1 |
0.716 | -0.015 | 1 | 0.703 |
IRE1 |
0.716 | 0.013 | 1 | 0.695 |
PKN2 |
0.715 | 0.031 | -3 | 0.741 |
BCKDK |
0.715 | -0.004 | -1 | 0.215 |
TSSK1 |
0.715 | 0.057 | -3 | 0.795 |
AMPKA2 |
0.715 | 0.057 | -3 | 0.739 |
MLK1 |
0.715 | -0.066 | 2 | 0.705 |
GRK5 |
0.715 | -0.070 | -3 | 0.761 |
CAMLCK |
0.715 | 0.003 | -2 | 0.794 |
IKKA |
0.714 | -0.015 | -2 | 0.730 |
TGFBR2 |
0.714 | -0.036 | -2 | 0.713 |
IKKB |
0.714 | -0.114 | -2 | 0.723 |
P70S6KB |
0.714 | 0.016 | -3 | 0.717 |
LATS1 |
0.714 | 0.067 | -3 | 0.795 |
MAPKAPK2 |
0.713 | 0.030 | -3 | 0.681 |
DAPK2 |
0.713 | 0.011 | -3 | 0.781 |
SIK |
0.713 | 0.135 | -3 | 0.689 |
DSTYK |
0.713 | -0.088 | 2 | 0.731 |
PRKX |
0.713 | 0.062 | -3 | 0.637 |
MASTL |
0.713 | 0.030 | -2 | 0.803 |
CAMK2D |
0.712 | 0.013 | -3 | 0.753 |
PAK1 |
0.712 | 0.010 | -2 | 0.755 |
BMPR1B |
0.712 | 0.023 | 1 | 0.693 |
PIM2 |
0.712 | 0.058 | -3 | 0.682 |
IKKE |
0.711 | -0.071 | 1 | 0.566 |
AKT2 |
0.711 | 0.060 | -3 | 0.643 |
RIPK3 |
0.711 | -0.084 | 3 | 0.719 |
SGK3 |
0.711 | 0.089 | -3 | 0.697 |
NEK9 |
0.710 | -0.036 | 2 | 0.725 |
GRK1 |
0.710 | -0.024 | -2 | 0.743 |
MAPKAPK3 |
0.710 | -0.016 | -3 | 0.711 |
MNK1 |
0.710 | 0.027 | -2 | 0.751 |
MST3 |
0.710 | 0.158 | 2 | 0.750 |
DNAPK |
0.710 | 0.102 | 1 | 0.602 |
PHKG1 |
0.709 | -0.004 | -3 | 0.751 |
PRKD3 |
0.709 | 0.019 | -3 | 0.691 |
PKR |
0.709 | 0.032 | 1 | 0.736 |
ERK7 |
0.709 | 0.086 | 2 | 0.485 |
GSK3A |
0.709 | 0.116 | 4 | 0.434 |
JNK1 |
0.708 | 0.200 | 1 | 0.810 |
TAO3 |
0.708 | 0.166 | 1 | 0.663 |
CAMK2G |
0.708 | -0.093 | 2 | 0.641 |
QIK |
0.708 | 0.100 | -3 | 0.739 |
PKCH |
0.708 | 0.040 | 2 | 0.619 |
IRE2 |
0.707 | -0.009 | 2 | 0.618 |
MLK4 |
0.707 | -0.037 | 2 | 0.622 |
PAK3 |
0.707 | -0.018 | -2 | 0.744 |
NEK7 |
0.707 | -0.128 | -3 | 0.726 |
DCAMKL1 |
0.707 | 0.081 | -3 | 0.728 |
NUAK1 |
0.706 | 0.017 | -3 | 0.704 |
SMG1 |
0.706 | -0.024 | 1 | 0.697 |
MARK3 |
0.705 | 0.112 | 4 | 0.755 |
MSK2 |
0.704 | 0.004 | -3 | 0.698 |
PKCT |
0.704 | 0.067 | 2 | 0.626 |
FAM20C |
0.704 | 0.002 | 2 | 0.444 |
CAMK2A |
0.704 | -0.010 | 2 | 0.641 |
ATM |
0.704 | -0.025 | 1 | 0.676 |
VRK2 |
0.703 | 0.062 | 1 | 0.783 |
TSSK2 |
0.703 | -0.039 | -5 | 0.745 |
RIPK1 |
0.703 | -0.091 | 1 | 0.696 |
TLK2 |
0.703 | -0.000 | 1 | 0.646 |
AURB |
0.702 | -0.007 | -2 | 0.589 |
MELK |
0.702 | -0.022 | -3 | 0.721 |
DLK |
0.702 | -0.134 | 1 | 0.688 |
HUNK |
0.702 | -0.094 | 2 | 0.645 |
NEK2 |
0.702 | -0.015 | 2 | 0.708 |
CAMK2B |
0.701 | -0.009 | 2 | 0.614 |
PKG2 |
0.701 | -0.005 | -2 | 0.618 |
YSK4 |
0.701 | -0.044 | 1 | 0.616 |
ULK1 |
0.700 | -0.124 | -3 | 0.690 |
WNK3 |
0.700 | -0.159 | 1 | 0.674 |
BUB1 |
0.700 | 0.092 | -5 | 0.712 |
PKCE |
0.699 | 0.066 | 2 | 0.635 |
MSK1 |
0.699 | 0.005 | -3 | 0.693 |
TGFBR1 |
0.699 | -0.009 | -2 | 0.740 |
ALK4 |
0.699 | -0.049 | -2 | 0.767 |
ANKRD3 |
0.699 | -0.153 | 1 | 0.722 |
PLK4 |
0.698 | 0.057 | 2 | 0.472 |
PAK6 |
0.697 | -0.012 | -2 | 0.642 |
CHAK1 |
0.697 | -0.097 | 2 | 0.663 |
AKT1 |
0.697 | 0.047 | -3 | 0.655 |
MEK1 |
0.697 | -0.026 | 2 | 0.693 |
PKACA |
0.697 | 0.038 | -2 | 0.558 |
GRK4 |
0.697 | -0.122 | -2 | 0.775 |
MEKK2 |
0.697 | 0.055 | 2 | 0.677 |
MARK2 |
0.696 | 0.088 | 4 | 0.713 |
CK1E |
0.696 | 0.012 | -3 | 0.524 |
AKT3 |
0.696 | 0.061 | -3 | 0.602 |
PKCI |
0.696 | 0.034 | 2 | 0.647 |
GRK6 |
0.696 | -0.117 | 1 | 0.705 |
PAK2 |
0.696 | -0.046 | -2 | 0.735 |
NEK5 |
0.696 | 0.008 | 1 | 0.700 |
WNK4 |
0.695 | 0.012 | -2 | 0.857 |
GCK |
0.695 | 0.139 | 1 | 0.651 |
MEKK1 |
0.695 | 0.025 | 1 | 0.672 |
BRSK1 |
0.695 | -0.007 | -3 | 0.723 |
TNIK |
0.695 | 0.150 | 3 | 0.838 |
PASK |
0.694 | -0.005 | -3 | 0.798 |
TTBK2 |
0.694 | -0.135 | 2 | 0.573 |
LKB1 |
0.693 | 0.053 | -3 | 0.745 |
ACVR2A |
0.693 | -0.062 | -2 | 0.712 |
MEK5 |
0.693 | -0.024 | 2 | 0.690 |
BRSK2 |
0.693 | -0.014 | -3 | 0.727 |
SGK1 |
0.693 | 0.080 | -3 | 0.577 |
ACVR2B |
0.693 | -0.062 | -2 | 0.728 |
ZAK |
0.693 | -0.016 | 1 | 0.629 |
IRAK4 |
0.693 | -0.046 | 1 | 0.689 |
KHS1 |
0.693 | 0.160 | 1 | 0.629 |
KHS2 |
0.693 | 0.155 | 1 | 0.646 |
CHK1 |
0.693 | -0.028 | -3 | 0.740 |
PINK1 |
0.692 | -0.034 | 1 | 0.815 |
PBK |
0.692 | 0.115 | 1 | 0.730 |
AURA |
0.691 | -0.018 | -2 | 0.551 |
ALK2 |
0.691 | -0.051 | -2 | 0.731 |
HGK |
0.691 | 0.114 | 3 | 0.837 |
CAMK4 |
0.691 | -0.104 | -3 | 0.723 |
DRAK1 |
0.690 | -0.064 | 1 | 0.645 |
MAP3K15 |
0.690 | 0.181 | 1 | 0.618 |
MARK1 |
0.690 | 0.061 | 4 | 0.775 |
HPK1 |
0.690 | 0.113 | 1 | 0.641 |
MEKK6 |
0.690 | 0.140 | 1 | 0.651 |
PERK |
0.689 | -0.100 | -2 | 0.751 |
TAO2 |
0.689 | 0.060 | 2 | 0.722 |
GSK3B |
0.689 | 0.032 | 4 | 0.427 |
ROCK2 |
0.688 | 0.058 | -3 | 0.716 |
MYLK4 |
0.688 | -0.058 | -2 | 0.705 |
BMPR1A |
0.688 | -0.023 | 1 | 0.669 |
DCAMKL2 |
0.687 | -0.002 | -3 | 0.732 |
BRAF |
0.687 | -0.066 | -4 | 0.621 |
P70S6K |
0.686 | -0.009 | -3 | 0.636 |
CK1G1 |
0.686 | 0.006 | -3 | 0.518 |
NEK11 |
0.686 | 0.031 | 1 | 0.648 |
HASPIN |
0.685 | 0.008 | -1 | 0.153 |
GRK2 |
0.685 | -0.063 | -2 | 0.684 |
CK1D |
0.685 | -0.001 | -3 | 0.473 |
GAK |
0.685 | 0.033 | 1 | 0.792 |
MINK |
0.685 | 0.101 | 1 | 0.634 |
CAMK1G |
0.685 | -0.038 | -3 | 0.682 |
PDK1 |
0.685 | 0.037 | 1 | 0.668 |
LOK |
0.685 | 0.012 | -2 | 0.739 |
HRI |
0.685 | -0.144 | -2 | 0.790 |
NEK4 |
0.684 | 0.030 | 1 | 0.653 |
PLK1 |
0.684 | -0.154 | -2 | 0.749 |
SSTK |
0.683 | -0.041 | 4 | 0.796 |
MEKK3 |
0.683 | -0.092 | 1 | 0.662 |
PAK5 |
0.683 | -0.027 | -2 | 0.605 |
LRRK2 |
0.683 | 0.040 | 2 | 0.710 |
YSK1 |
0.682 | 0.125 | 2 | 0.725 |
NEK1 |
0.682 | 0.074 | 1 | 0.672 |
MAPKAPK5 |
0.682 | -0.090 | -3 | 0.652 |
EEF2K |
0.680 | 0.028 | 3 | 0.782 |
MRCKB |
0.680 | 0.015 | -3 | 0.662 |
PHKG2 |
0.680 | -0.044 | -3 | 0.705 |
SNRK |
0.680 | -0.123 | 2 | 0.519 |
SMMLCK |
0.679 | -0.045 | -3 | 0.730 |
PLK3 |
0.679 | -0.128 | 2 | 0.581 |
DAPK3 |
0.679 | -0.013 | -3 | 0.734 |
PAK4 |
0.679 | -0.027 | -2 | 0.604 |
CK1A2 |
0.679 | -0.011 | -3 | 0.473 |
SBK |
0.679 | 0.050 | -3 | 0.542 |
MST2 |
0.679 | -0.002 | 1 | 0.653 |
SLK |
0.678 | -0.041 | -2 | 0.710 |
CAMKK2 |
0.678 | -0.055 | -2 | 0.700 |
PKN1 |
0.677 | -0.005 | -3 | 0.655 |
MYO3B |
0.677 | 0.121 | 2 | 0.735 |
MRCKA |
0.676 | 0.007 | -3 | 0.674 |
CAMK1D |
0.676 | -0.032 | -3 | 0.630 |
CK2A2 |
0.675 | -0.016 | 1 | 0.639 |
TLK1 |
0.675 | -0.143 | -2 | 0.773 |
CRIK |
0.675 | 0.059 | -3 | 0.658 |
CAMKK1 |
0.674 | -0.113 | -2 | 0.696 |
NEK8 |
0.674 | -0.141 | 2 | 0.689 |
GRK3 |
0.672 | -0.062 | -2 | 0.635 |
DMPK1 |
0.672 | 0.032 | -3 | 0.686 |
NEK3 |
0.671 | 0.037 | 1 | 0.625 |
OSR1 |
0.671 | 0.001 | 2 | 0.699 |
ROCK1 |
0.671 | 0.024 | -3 | 0.675 |
VRK1 |
0.669 | -0.074 | 2 | 0.661 |
STK33 |
0.669 | -0.089 | 2 | 0.482 |
MST1 |
0.669 | -0.030 | 1 | 0.633 |
CHK2 |
0.669 | -0.023 | -3 | 0.593 |
DAPK1 |
0.668 | -0.033 | -3 | 0.719 |
TAK1 |
0.667 | -0.135 | 1 | 0.655 |
CK2A1 |
0.666 | -0.023 | 1 | 0.620 |
MEK2 |
0.666 | -0.037 | 2 | 0.677 |
TAO1 |
0.665 | 0.043 | 1 | 0.579 |
MYO3A |
0.665 | 0.076 | 1 | 0.657 |
BIKE |
0.664 | 0.046 | 1 | 0.724 |
CAMK1A |
0.664 | -0.028 | -3 | 0.606 |
IRAK1 |
0.663 | -0.220 | -1 | 0.116 |
PKMYT1_TYR |
0.662 | 0.363 | 3 | 0.830 |
PDHK3_TYR |
0.661 | 0.209 | 4 | 0.872 |
AAK1 |
0.661 | 0.097 | 1 | 0.661 |
TTBK1 |
0.660 | -0.174 | 2 | 0.485 |
TTK |
0.660 | -0.058 | -2 | 0.758 |
ASK1 |
0.660 | 0.039 | 1 | 0.608 |
LIMK2_TYR |
0.659 | 0.178 | -3 | 0.788 |
PLK2 |
0.657 | -0.081 | -3 | 0.716 |
MAP2K4_TYR |
0.657 | 0.255 | -1 | 0.232 |
TESK1_TYR |
0.655 | 0.102 | 3 | 0.854 |
PKG1 |
0.655 | -0.049 | -2 | 0.530 |
CK1A |
0.654 | -0.021 | -3 | 0.397 |
PDHK4_TYR |
0.653 | 0.103 | 2 | 0.717 |
YANK3 |
0.653 | -0.030 | 2 | 0.297 |
MAP2K6_TYR |
0.651 | 0.103 | -1 | 0.209 |
MAP2K7_TYR |
0.647 | 0.103 | 2 | 0.700 |
RIPK2 |
0.646 | -0.212 | 1 | 0.584 |
LIMK1_TYR |
0.645 | 0.075 | 2 | 0.705 |
ALPHAK3 |
0.644 | -0.094 | -1 | 0.137 |
PDHK1_TYR |
0.644 | -0.008 | -1 | 0.177 |
BMPR2_TYR |
0.643 | -0.003 | -1 | 0.204 |
PINK1_TYR |
0.639 | -0.057 | 1 | 0.732 |
TNNI3K_TYR |
0.639 | 0.073 | 1 | 0.693 |
ABL2 |
0.639 | -0.011 | -1 | 0.116 |
TXK |
0.638 | -0.012 | 1 | 0.720 |
ABL1 |
0.636 | -0.017 | -1 | 0.119 |
STLK3 |
0.635 | -0.125 | 1 | 0.594 |
ROS1 |
0.634 | -0.035 | 3 | 0.744 |
RET |
0.634 | -0.105 | 1 | 0.670 |
TNK1 |
0.633 | 0.020 | 3 | 0.766 |
EPHB4 |
0.633 | -0.077 | -1 | 0.103 |
FGR |
0.633 | -0.071 | 1 | 0.732 |
JAK2 |
0.632 | -0.022 | 1 | 0.659 |
LCK |
0.632 | -0.045 | -1 | 0.110 |
TYRO3 |
0.631 | -0.106 | 3 | 0.775 |
YES1 |
0.631 | -0.052 | -1 | 0.140 |
EPHA6 |
0.631 | -0.101 | -1 | 0.111 |
MST1R |
0.631 | -0.079 | 3 | 0.785 |
TYK2 |
0.631 | -0.049 | 1 | 0.657 |
CSF1R |
0.630 | -0.061 | 3 | 0.767 |
TNK2 |
0.630 | -0.036 | 3 | 0.710 |
NEK10_TYR |
0.629 | 0.009 | 1 | 0.552 |
BLK |
0.628 | -0.037 | -1 | 0.116 |
JAK1 |
0.627 | 0.027 | 1 | 0.590 |
ITK |
0.626 | -0.091 | -1 | 0.104 |
WEE1_TYR |
0.626 | -0.058 | -1 | 0.128 |
HCK |
0.626 | -0.100 | -1 | 0.115 |
BMX |
0.624 | -0.086 | -1 | 0.080 |
FER |
0.624 | -0.151 | 1 | 0.736 |
JAK3 |
0.623 | -0.127 | 1 | 0.644 |
YANK2 |
0.621 | -0.047 | 2 | 0.310 |
KDR |
0.620 | -0.093 | 3 | 0.725 |
DDR1 |
0.620 | -0.142 | 4 | 0.789 |
MERTK |
0.620 | -0.106 | 3 | 0.747 |
MET |
0.620 | -0.093 | 3 | 0.759 |
FYN |
0.620 | -0.067 | -1 | 0.111 |
PTK6 |
0.620 | -0.148 | -1 | 0.090 |
KIT |
0.619 | -0.126 | 3 | 0.768 |
EPHA4 |
0.618 | -0.100 | 2 | 0.586 |
AXL |
0.618 | -0.133 | 3 | 0.746 |
SRMS |
0.618 | -0.153 | 1 | 0.708 |
EPHB3 |
0.617 | -0.135 | -1 | 0.084 |
CK1G3 |
0.617 | -0.064 | -3 | 0.357 |
TEC |
0.617 | -0.138 | -1 | 0.086 |
INSRR |
0.616 | -0.150 | 3 | 0.712 |
PDGFRB |
0.616 | -0.159 | 3 | 0.772 |
FGFR2 |
0.615 | -0.151 | 3 | 0.753 |
EPHB2 |
0.614 | -0.144 | -1 | 0.081 |
EPHB1 |
0.613 | -0.181 | 1 | 0.692 |
MATK |
0.613 | -0.099 | -1 | 0.096 |
FLT3 |
0.612 | -0.157 | 3 | 0.773 |
LYN |
0.612 | -0.107 | 3 | 0.704 |
PTK2B |
0.612 | -0.085 | -1 | 0.097 |
TEK |
0.611 | -0.142 | 3 | 0.708 |
FGFR1 |
0.611 | -0.140 | 3 | 0.724 |
BTK |
0.611 | -0.202 | -1 | 0.095 |
FLT1 |
0.610 | -0.153 | -1 | 0.112 |
SRC |
0.609 | -0.089 | -1 | 0.121 |
ALK |
0.609 | -0.155 | 3 | 0.673 |
EPHA1 |
0.609 | -0.130 | 3 | 0.736 |
DDR2 |
0.609 | -0.052 | 3 | 0.681 |
PDGFRA |
0.608 | -0.166 | 3 | 0.767 |
LTK |
0.608 | -0.156 | 3 | 0.697 |
EPHA7 |
0.607 | -0.129 | 2 | 0.580 |
NTRK3 |
0.607 | -0.126 | -1 | 0.108 |
FRK |
0.606 | -0.137 | -1 | 0.101 |
FGFR3 |
0.605 | -0.160 | 3 | 0.725 |
EPHA3 |
0.604 | -0.158 | 2 | 0.560 |
PTK2 |
0.604 | -0.082 | -1 | 0.112 |
CSK |
0.604 | -0.116 | 2 | 0.595 |
INSR |
0.603 | -0.145 | 3 | 0.701 |
NTRK1 |
0.602 | -0.196 | -1 | 0.124 |
ERBB2 |
0.602 | -0.167 | 1 | 0.614 |
EPHA8 |
0.600 | -0.137 | -1 | 0.082 |
NTRK2 |
0.600 | -0.207 | 3 | 0.728 |
ZAP70 |
0.599 | -0.047 | -1 | 0.105 |
SYK |
0.598 | -0.110 | -1 | 0.090 |
FGFR4 |
0.598 | -0.124 | -1 | 0.098 |
EPHA5 |
0.598 | -0.155 | 2 | 0.552 |
FLT4 |
0.597 | -0.197 | 3 | 0.719 |
CK1G2 |
0.596 | -0.077 | -3 | 0.440 |
EGFR |
0.595 | -0.124 | 1 | 0.533 |
MUSK |
0.590 | -0.138 | 1 | 0.524 |
EPHA2 |
0.589 | -0.146 | -1 | 0.069 |
IGF1R |
0.587 | -0.158 | 3 | 0.650 |
ERBB4 |
0.585 | -0.110 | 1 | 0.562 |
FES |
0.582 | -0.139 | -1 | 0.079 |