Motif 283 (n=162)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S168 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0FGR8 | ESYT2 | S685 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| A1L170 | C1orf226 | S30 | ochoa | Uncharacterized protein C1orf226 | None |
| A6NKD9 | CCDC85C | T161 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A7E2V4 | ZSWIM8 | S48 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A7KAX9 | ARHGAP32 | S2031 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| B0I1T2 | MYO1G | S325 | ochoa | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)] | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}. |
| H7C1W4 | None | S25 | ochoa | Uncharacterized protein | None |
| K7EM74 | None | S151 | ochoa | Zinc finger protein 653 | None |
| O00330 | PDHX | S196 | ochoa | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
| O14545 | TRAFD1 | S528 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O15211 | RGL2 | S748 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15534 | PER1 | S811 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O60381 | HBP1 | S372 | psp | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60884 | DNAJA2 | Y69 | ochoa | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877}. |
| O75369 | FLNB | S2307 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1742 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75962 | TRIO | S2282 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O76061 | STC2 | S250 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
| O94819 | KBTBD11 | S508 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O95232 | LUC7L3 | S110 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| P02671 | FGA | S291 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P05783 | KRT18 | S31 | ochoa|psp | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P05783 | KRT18 | S49 | ochoa|psp | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P08913 | ADRA2A | S247 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
| P09651 | HNRNPA1 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09651 | HNRNPA1 | S191 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P14317 | HCLS1 | S112 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14373 | TRIM27 | S493 | ochoa | Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) | E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-alpha-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (PubMed:26358190, PubMed:29688809). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (PubMed:22829933). Alternatively, facilitates mitophagy via stabilization of active TBK1 (PubMed:36111389). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (PubMed:35670107). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (PubMed:35670107). {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:22829933, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:26358190, ECO:0000269|PubMed:29688809, ECO:0000269|PubMed:35670107, ECO:0000269|PubMed:36111389}.; FUNCTION: (Microbial infection) Positively regulates hepatitis C virus replication by suppressing type I IFN response during infection. {ECO:0000269|PubMed:29688809}. |
| P17275 | JUNB | Y47 | psp | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| P17600 | SYN1 | S62 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18615 | NELFE | S140 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P21359 | NF1 | S665 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P22626 | HNRNPA2B1 | S198 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P25440 | BRD2 | S591 | ochoa | Bromodomain-containing protein 2 (O27.1.1) | Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269|PubMed:17148447, ECO:0000269|PubMed:17848202, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:20048151, ECO:0000269|PubMed:20709061, ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:35410381, ECO:0000269|PubMed:37731000}. |
| P27815 | PDE4A | S89 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P29692 | EEF1D | S65 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P30086 | PEBP1 | S98 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P35716 | SOX11 | S135 | ochoa | Transcription factor SOX-11 | Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2, ECO:0000269|PubMed:24886874, ECO:0000269|PubMed:26543203}. |
| P38936 | CDKN1A | S123 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P39019 | RPS19 | S59 | psp | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P41440 | SLC19A1 | S223 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
| P42261 | GRIA1 | S863 | psp | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| P49321 | NASP | S678 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P52272 | HNRNPM | S633 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P54760 | EPHB4 | S769 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P56693 | SOX10 | S27 | ochoa | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P57737 | CORO7 | S668 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P62995 | TRA2B | Y235 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P67809 | YBX1 | S21 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78316 | NOP14 | S157 | ochoa | Nucleolar protein 14 (Nucleolar complex protein 14) | Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}. |
| P98172 | EFNB1 | S283 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| Q01130 | SRSF2 | S101 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q01813 | PFKP | S21 | ochoa | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| Q02156 | PRKCE | S380 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q03468 | ERCC6 | S430 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q09019 | DMWD | S545 | ochoa | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}. |
| Q09472 | EP300 | S89 | ochoa|psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q09666 | AHNAK | S5332 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13371 | PDCL | S40 | ochoa | Phosducin-like protein (PHLP) | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}.; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. |
| Q13526 | PIN1 | S32 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13526 | PIN1 | S138 | psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13685 | AAMP | S248 | ochoa | Angio-associated migratory cell protein | Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}. |
| Q14157 | UBAP2L | S337 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14247 | CTTN | S113 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S150 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S261 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14247 | CTTN | S298 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14315 | FLNC | S2428 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14498 | RBM39 | S100 | ochoa | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q15464 | SHB | S190 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q15758 | SLC1A5 | S27 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q15768 | EFNB3 | S268 | ochoa | Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for nipah virus and hendra virus. {ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| Q16576 | RBBP7 | S95 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q4KMP7 | TBC1D10B | S248 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q53GG5 | PDLIM3 | S273 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5C9Z4 | NOM1 | S57 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5FWE3 | PRRT3 | S769 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5FWE3 | PRRT3 | S774 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5PRF9 | SAMD4B | S172 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5PRF9 | SAMD4B | S555 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5VT52 | RPRD2 | S1144 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q69YZ2 | TMEM200B | S282 | ochoa | Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B) | None |
| Q6DT37 | CDC42BPG | S1484 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6P1R3 | MSANTD2 | S54 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6ZNJ1 | NBEAL2 | S1363 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q7KZI7 | MARK2 | S619 | ochoa|psp | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7RTP6 | MICAL3 | S862 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2W4 | ZC3HAV1 | S335 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z460 | CLASP1 | S686 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q86U70 | LDB1 | S294 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86UR5 | RIMS1 | S1414 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q8IZD0 | SAMD14 | S56 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8NC51 | SERBP1 | S353 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NHG8 | ZNRF2 | S27 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAP9 | MPLKIP | S72 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TF76 | HASPIN | S317 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUI4 | HDAC7 | S405 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q92945 | KHSRP | S395 | psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q93075 | TATDN2 | S82 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96FF9 | CDCA5 | S154 | ochoa | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96GS4 | BORCS6 | S173 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96KQ4 | PPP1R13B | S709 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96MG7 | NSMCE3 | S49 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96N67 | DOCK7 | Y859 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PD2 | DCBLD2 | S618 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96PE1 | ADGRA2 | S991 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
| Q96QE2 | SLC2A13 | S48 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96RI0 | F2RL3 | S366 | ochoa | Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) | Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109). {ECO:0000269|PubMed:10079109}. |
| Q96T37 | RBM15 | S269 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96T51 | RUFY1 | S80 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q9BUN8 | DERL1 | S226 | ochoa | Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1) | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (PubMed:15215856, PubMed:33658201). Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane (PubMed:33658201). This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:33658201). The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first (PubMed:33658201). May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:33658201}.; FUNCTION: (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856}. |
| Q9BXL6 | CARD14 | S498 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BXS6 | NUSAP1 | S255 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9C0C2 | TNKS1BP1 | S1013 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H4L4 | SENP3 | S238 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H4Q3 | PRDM13 | T545 | ochoa | PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13) | May be involved in transcriptional regulation. Is required for the differentiation of KISS1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (By similarity). {ECO:0000250|UniProtKB:E9PZZ1}. |
| Q9NQW6 | ANLN | S356 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR12 | PDLIM7 | S260 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRR3 | CDC42SE2 | S55 | ochoa | CDC42 small effector protein 2 (Small effector of CDC42 protein 2) | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}. |
| Q9NS62 | THSD1 | S477 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
| Q9NSI6 | BRWD1 | S1786 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NUG4 | CCM2L | S200 | ochoa | Cerebral cavernous malformations 2 protein-like (CCM2-like) | None |
| Q9NUQ6 | SPATS2L | S518 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NVP1 | DDX18 | S627 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9NZN5 | ARHGEF12 | S1308 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P244 | LRFN1 | S580 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P244 | LRFN1 | S731 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P260 | RELCH | S141 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9P270 | SLAIN2 | S35 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UBY9 | HSPB7 | S60 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
| Q9UHI5 | SLC7A8 | S21 | ochoa | Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8) | Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11847106, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. |
| Q9UKJ3 | GPATCH8 | S635 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKX2 | MYH2 | S625 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKY7 | CDV3 | S30 | ochoa | Protein CDV3 homolog | None |
| Q9UM47 | NOTCH3 | S2028 | ochoa | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}. |
| Q9UMS6 | SYNPO2 | S712 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMS6 | SYNPO2 | S717 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPU7 | TBC1D2B | S317 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y2I9 | TBC1D30 | S91 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| Q9Y2K6 | USP20 | S289 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2U8 | LEMD3 | S111 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2X7 | GIT1 | S514 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3Q8 | TSC22D4 | S104 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4F3 | MARF1 | S110 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y4F3 | MARF1 | S112 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y4H2 | IRS2 | S400 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S523 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5M8 | SRPRB | S219 | ochoa | Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) | Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity). {ECO:0000250|UniProtKB:P47758}. |
| P61604 | HSPE1 | T45 | Sugiyama | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}. |
| P31153 | MAT2A | S247 | Sugiyama | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
| Q9GZZ9 | UBA5 | S24 | Sugiyama | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q14103 | HNRNPD | S271 | Sugiyama | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}. |
| Q16881 | TXNRD1 | Y161 | Sugiyama | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) | Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). {ECO:0000269|PubMed:10849437, ECO:0000269|PubMed:8577704, ECO:0000305|PubMed:17512005}.; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704}.; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. {ECO:0000269|PubMed:15199063}.; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:9774665}. |
| Q8NDV7 | TNRC6A | S1047 | Sugiyama | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| O60245 | PCDH7 | Y180 | Sugiyama | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
| P17987 | TCP1 | S27 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q6PHR2 | ULK3 | S384 | GPS6|SIGNOR|EPSD|PSP | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| P57721 | PCBP3 | S139 | Sugiyama | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| Q15366 | PCBP2 | S107 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q9NWZ3 | IRAK4 | S186 | Sugiyama | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q96T58 | SPEN | S99 | Sugiyama | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000042 | 4.378 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000042 | 4.378 |
| R-HSA-3928664 | Ephrin signaling | 0.000124 | 3.907 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.000118 | 3.928 |
| R-HSA-72172 | mRNA Splicing | 0.000177 | 3.753 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000261 | 3.584 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000745 | 3.128 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.000695 | 3.158 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000738 | 3.132 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.000896 | 3.048 |
| R-HSA-162582 | Signal Transduction | 0.000983 | 3.007 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.001388 | 2.858 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.001392 | 2.856 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.001600 | 2.796 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.001980 | 2.703 |
| R-HSA-157118 | Signaling by NOTCH | 0.002164 | 2.665 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.002542 | 2.595 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.003471 | 2.460 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.003521 | 2.453 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.003471 | 2.460 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.003233 | 2.490 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.004760 | 2.322 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.004742 | 2.324 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.005167 | 2.287 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.005176 | 2.286 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.006515 | 2.186 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.006515 | 2.186 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.006515 | 2.186 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.006515 | 2.186 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.006515 | 2.186 |
| R-HSA-9675108 | Nervous system development | 0.005873 | 2.231 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.006535 | 2.185 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.006627 | 2.179 |
| R-HSA-422475 | Axon guidance | 0.008531 | 2.069 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.008305 | 2.081 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.009499 | 2.022 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.009669 | 2.015 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.009669 | 2.015 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.010845 | 1.965 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.011754 | 1.930 |
| R-HSA-8953854 | Metabolism of RNA | 0.011180 | 1.952 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.013125 | 1.882 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.013308 | 1.876 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.013067 | 1.884 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.013308 | 1.876 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.014597 | 1.836 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.014714 | 1.832 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.017833 | 1.749 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.017019 | 1.769 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.017171 | 1.765 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.018581 | 1.731 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.019020 | 1.721 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.019905 | 1.701 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.020589 | 1.686 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.021319 | 1.671 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.021836 | 1.661 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.021991 | 1.658 |
| R-HSA-9909396 | Circadian clock | 0.022534 | 1.647 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.024105 | 1.618 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.024105 | 1.618 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.021836 | 1.661 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.023035 | 1.638 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.024221 | 1.616 |
| R-HSA-6807070 | PTEN Regulation | 0.027417 | 1.562 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.025832 | 1.588 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.025832 | 1.588 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.025832 | 1.588 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.027417 | 1.562 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.029921 | 1.524 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.034626 | 1.461 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.031081 | 1.507 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.031081 | 1.507 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.031871 | 1.497 |
| R-HSA-2262752 | Cellular responses to stress | 0.031325 | 1.504 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.032336 | 1.490 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.031684 | 1.499 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.034626 | 1.461 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.034925 | 1.457 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.036982 | 1.432 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.036982 | 1.432 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.036982 | 1.432 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.037330 | 1.428 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.037330 | 1.428 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.037618 | 1.425 |
| R-HSA-9839394 | TGFBR3 expression | 0.044402 | 1.353 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.040616 | 1.391 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.041850 | 1.378 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.044134 | 1.355 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.039333 | 1.405 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.041871 | 1.378 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.044799 | 1.349 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.046311 | 1.334 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.046988 | 1.328 |
| R-HSA-449147 | Signaling by Interleukins | 0.047103 | 1.327 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.049628 | 1.304 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.052307 | 1.281 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 0.052307 | 1.281 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.062438 | 1.205 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.062438 | 1.205 |
| R-HSA-399710 | Activation of AMPA receptors | 0.072460 | 1.140 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.072460 | 1.140 |
| R-HSA-74713 | IRS activation | 0.072460 | 1.140 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.082376 | 1.084 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.092187 | 1.035 |
| R-HSA-5263617 | Metabolism of ingested MeSeO2H into MeSeH | 0.092187 | 1.035 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.092187 | 1.035 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.101894 | 0.992 |
| R-HSA-112412 | SOS-mediated signalling | 0.101894 | 0.992 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.111497 | 0.953 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.120998 | 0.917 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.130398 | 0.885 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.130398 | 0.885 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.139698 | 0.855 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.148900 | 0.827 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.158003 | 0.801 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.167010 | 0.777 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.167010 | 0.777 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.057857 | 1.238 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.184737 | 0.733 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.184737 | 0.733 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.193459 | 0.713 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.193459 | 0.713 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.072520 | 1.140 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.072520 | 1.140 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.078687 | 1.104 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.078687 | 1.104 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.210626 | 0.676 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.088230 | 1.054 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.219073 | 0.659 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.227430 | 0.643 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.227430 | 0.643 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.101451 | 0.994 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.235698 | 0.628 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.235698 | 0.628 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.243878 | 0.613 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.115176 | 0.939 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.267900 | 0.572 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.275737 | 0.560 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.140217 | 0.853 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.298752 | 0.525 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.298752 | 0.525 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.166288 | 0.779 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.306261 | 0.514 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.306261 | 0.514 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.313690 | 0.503 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.275810 | 0.559 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.167010 | 0.777 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.057857 | 1.238 |
| R-HSA-198203 | PI3K/AKT activation | 0.130398 | 0.885 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.158003 | 0.801 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.111701 | 0.952 |
| R-HSA-774815 | Nucleosome assembly | 0.111701 | 0.952 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.158003 | 0.801 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.319243 | 0.496 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.072460 | 1.140 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.175921 | 0.755 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.072520 | 1.140 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.081830 | 1.087 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.098095 | 1.008 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.299551 | 0.524 |
| R-HSA-391251 | Protein folding | 0.299551 | 0.524 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.212596 | 0.672 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.202088 | 0.694 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.136570 | 0.865 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.178224 | 0.749 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.111701 | 0.952 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.291162 | 0.536 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.148900 | 0.827 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.115176 | 0.939 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.115176 | 0.939 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.115176 | 0.939 |
| R-HSA-9843745 | Adipogenesis | 0.075099 | 1.124 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.130398 | 0.885 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.148900 | 0.827 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.167010 | 0.777 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.167010 | 0.777 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.267900 | 0.572 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.212596 | 0.672 |
| R-HSA-418597 | G alpha (z) signalling events | 0.147574 | 0.831 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.158003 | 0.801 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.115176 | 0.939 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.110214 | 0.958 |
| R-HSA-74749 | Signal attenuation | 0.130398 | 0.885 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.184737 | 0.733 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.082376 | 1.084 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.101894 | 0.992 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.130398 | 0.885 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.251971 | 0.599 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.306261 | 0.514 |
| R-HSA-9707616 | Heme signaling | 0.173887 | 0.760 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.204777 | 0.689 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.309214 | 0.510 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.111701 | 0.952 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.196991 | 0.706 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.091484 | 1.039 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.091484 | 1.039 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.276199 | 0.559 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.055905 | 1.253 |
| R-HSA-429593 | Inositol transporters | 0.072460 | 1.140 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.120998 | 0.917 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.148900 | 0.827 |
| R-HSA-8963901 | Chylomicron remodeling | 0.167010 | 0.777 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.219073 | 0.659 |
| R-HSA-9710421 | Defective pyroptosis | 0.104837 | 0.979 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.243878 | 0.613 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.275737 | 0.560 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.291162 | 0.536 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.306261 | 0.514 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.173887 | 0.760 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.313690 | 0.503 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.287691 | 0.541 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.199360 | 0.700 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.060698 | 1.217 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.092187 | 1.035 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.175921 | 0.755 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.066521 | 1.177 |
| R-HSA-5260271 | Diseases of Immune System | 0.091484 | 1.039 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.091484 | 1.039 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.235698 | 0.628 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.202088 | 0.694 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.101894 | 0.992 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.120998 | 0.917 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.193459 | 0.713 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.275737 | 0.560 |
| R-HSA-429947 | Deadenylation of mRNA | 0.275737 | 0.560 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.291162 | 0.536 |
| R-HSA-69275 | G2/M Transition | 0.180105 | 0.744 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.064563 | 1.190 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.184360 | 0.734 |
| R-HSA-194138 | Signaling by VEGF | 0.191627 | 0.718 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.158003 | 0.801 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.208683 | 0.681 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.078712 | 1.104 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.115176 | 0.939 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.239788 | 0.620 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.104708 | 0.980 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.072460 | 1.140 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.101894 | 0.992 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.158003 | 0.801 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.158003 | 0.801 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.158003 | 0.801 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.219073 | 0.659 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.235698 | 0.628 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.243878 | 0.613 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.066365 | 1.178 |
| R-HSA-69242 | S Phase | 0.264633 | 0.577 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.120874 | 0.918 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.253745 | 0.596 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.066521 | 1.177 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.202088 | 0.694 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.210626 | 0.676 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.275737 | 0.560 |
| R-HSA-114608 | Platelet degranulation | 0.197060 | 0.705 |
| R-HSA-74160 | Gene expression (Transcription) | 0.304401 | 0.517 |
| R-HSA-390696 | Adrenoceptors | 0.111497 | 0.953 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.202088 | 0.694 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.078687 | 1.104 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.219073 | 0.659 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.291162 | 0.536 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.102392 | 0.990 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.122208 | 0.913 |
| R-HSA-1266738 | Developmental Biology | 0.285192 | 0.545 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.298752 | 0.525 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.077564 | 1.110 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.283491 | 0.547 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.157290 | 0.803 |
| R-HSA-1989781 | PPARA activates gene expression | 0.117272 | 0.931 |
| R-HSA-2559583 | Cellular Senescence | 0.064765 | 1.189 |
| R-HSA-9635465 | Suppression of apoptosis | 0.139698 | 0.855 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.184737 | 0.733 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 0.210626 | 0.676 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.251971 | 0.599 |
| R-HSA-9620244 | Long-term potentiation | 0.283491 | 0.547 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.306261 | 0.514 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.313690 | 0.503 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.204777 | 0.689 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.216354 | 0.665 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.235698 | 0.628 |
| R-HSA-212436 | Generic Transcription Pathway | 0.176590 | 0.753 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.208683 | 0.681 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.217256 | 0.663 |
| R-HSA-5619084 | ABC transporter disorders | 0.236208 | 0.627 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.193459 | 0.713 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.275737 | 0.560 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.122954 | 0.910 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.212596 | 0.672 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.224378 | 0.649 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.263919 | 0.579 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.267883 | 0.572 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.243878 | 0.613 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.083562 | 1.078 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.158003 | 0.801 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.243878 | 0.613 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.125762 | 0.900 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.298752 | 0.525 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.173887 | 0.760 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.139876 | 0.854 |
| R-HSA-2586552 | Signaling by Leptin | 0.130398 | 0.885 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.259978 | 0.585 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.167010 | 0.777 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.184737 | 0.733 |
| R-HSA-210991 | Basigin interactions | 0.243878 | 0.613 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.062785 | 1.202 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.263919 | 0.579 |
| R-HSA-418990 | Adherens junctions interactions | 0.115065 | 0.939 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.199790 | 0.699 |
| R-HSA-421270 | Cell-cell junction organization | 0.168568 | 0.773 |
| R-HSA-446728 | Cell junction organization | 0.103658 | 0.984 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.184737 | 0.733 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.291647 | 0.535 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.244114 | 0.612 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.153317 | 0.814 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.153317 | 0.814 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.162512 | 0.789 |
| R-HSA-4839726 | Chromatin organization | 0.165078 | 0.782 |
| R-HSA-180024 | DARPP-32 events | 0.313690 | 0.503 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.193112 | 0.714 |
| R-HSA-1500931 | Cell-Cell communication | 0.155189 | 0.809 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.107784 | 0.967 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.275810 | 0.559 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.081493 | 1.089 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.259978 | 0.585 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.066365 | 1.178 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.166288 | 0.779 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.108480 | 0.965 |
| R-HSA-166520 | Signaling by NTRKs | 0.264633 | 0.577 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.088230 | 1.054 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.057589 | 1.240 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.267900 | 0.572 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.204777 | 0.689 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.094773 | 1.023 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.192967 | 0.715 |
| R-HSA-8853659 | RET signaling | 0.078687 | 1.104 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.078687 | 1.104 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.267900 | 0.572 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.200100 | 0.699 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.157335 | 0.803 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.279772 | 0.553 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.115980 | 0.936 |
| R-HSA-73887 | Death Receptor Signaling | 0.282002 | 0.550 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.321040 | 0.493 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.321040 | 0.493 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.321040 | 0.493 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.321040 | 0.493 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.321040 | 0.493 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.327086 | 0.485 |
| R-HSA-190236 | Signaling by FGFR | 0.327086 | 0.485 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.328312 | 0.484 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.328312 | 0.484 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.328312 | 0.484 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.328312 | 0.484 |
| R-HSA-3214847 | HATs acetylate histones | 0.330998 | 0.480 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.331622 | 0.479 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.334904 | 0.475 |
| R-HSA-1538133 | G0 and Early G1 | 0.335506 | 0.474 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.335506 | 0.474 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.335506 | 0.474 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.342624 | 0.465 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 0.342624 | 0.465 |
| R-HSA-354192 | Integrin signaling | 0.342624 | 0.465 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.342624 | 0.465 |
| R-HSA-9733709 | Cardiogenesis | 0.342624 | 0.465 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.342697 | 0.465 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.342697 | 0.465 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.349665 | 0.456 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.349665 | 0.456 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.349665 | 0.456 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.349665 | 0.456 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.349745 | 0.456 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.356632 | 0.448 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.356632 | 0.448 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.356632 | 0.448 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.356632 | 0.448 |
| R-HSA-392518 | Signal amplification | 0.356632 | 0.448 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.363525 | 0.439 |
| R-HSA-381042 | PERK regulates gene expression | 0.363525 | 0.439 |
| R-HSA-416476 | G alpha (q) signalling events | 0.364313 | 0.439 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.365893 | 0.437 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.369730 | 0.432 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.370344 | 0.431 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.370344 | 0.431 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 0.377090 | 0.424 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.377090 | 0.424 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.377090 | 0.424 |
| R-HSA-1640170 | Cell Cycle | 0.383427 | 0.416 |
| R-HSA-8875878 | MET promotes cell motility | 0.383765 | 0.416 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.384065 | 0.416 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.390369 | 0.409 |
| R-HSA-201556 | Signaling by ALK | 0.390369 | 0.409 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.396319 | 0.402 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.396902 | 0.401 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.396902 | 0.401 |
| R-HSA-167169 | HIV Transcription Elongation | 0.396902 | 0.401 |
| R-HSA-3371568 | Attenuation phase | 0.396902 | 0.401 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.396902 | 0.401 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.396902 | 0.401 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.400077 | 0.398 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.403365 | 0.394 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.403365 | 0.394 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.403365 | 0.394 |
| R-HSA-9609690 | HCMV Early Events | 0.407113 | 0.390 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.409760 | 0.387 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.409760 | 0.387 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.409760 | 0.387 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.414997 | 0.382 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.418699 | 0.378 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.418699 | 0.378 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.418699 | 0.378 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.422346 | 0.374 |
| R-HSA-8854214 | TBC/RABGAPs | 0.422346 | 0.374 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.422346 | 0.374 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.426066 | 0.371 |
| R-HSA-73886 | Chromosome Maintenance | 0.426066 | 0.371 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.428538 | 0.368 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.428538 | 0.368 |
| R-HSA-69236 | G1 Phase | 0.428538 | 0.368 |
| R-HSA-373752 | Netrin-1 signaling | 0.428538 | 0.368 |
| R-HSA-156581 | Methylation | 0.428538 | 0.368 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.428538 | 0.368 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.428538 | 0.368 |
| R-HSA-5683826 | Surfactant metabolism | 0.428538 | 0.368 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.429732 | 0.367 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.429732 | 0.367 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.433386 | 0.363 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.433386 | 0.363 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.434665 | 0.362 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.434665 | 0.362 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.440726 | 0.356 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.440726 | 0.356 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.440726 | 0.356 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.444270 | 0.352 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.444270 | 0.352 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.444270 | 0.352 |
| R-HSA-69206 | G1/S Transition | 0.444270 | 0.352 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.452655 | 0.344 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.462152 | 0.335 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.464331 | 0.333 |
| R-HSA-109704 | PI3K Cascade | 0.464331 | 0.333 |
| R-HSA-68882 | Mitotic Anaphase | 0.466248 | 0.331 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.469003 | 0.329 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.470076 | 0.328 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.470076 | 0.328 |
| R-HSA-72187 | mRNA 3'-end processing | 0.475759 | 0.323 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.475759 | 0.323 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.475759 | 0.323 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.475759 | 0.323 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.475759 | 0.323 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.475759 | 0.323 |
| R-HSA-8951664 | Neddylation | 0.479959 | 0.319 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.481382 | 0.318 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.481382 | 0.318 |
| R-HSA-72649 | Translation initiation complex formation | 0.486945 | 0.313 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.486945 | 0.313 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.490055 | 0.310 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.493506 | 0.307 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.496889 | 0.304 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.497894 | 0.303 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.497894 | 0.303 |
| R-HSA-177929 | Signaling by EGFR | 0.497894 | 0.303 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.497894 | 0.303 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.497894 | 0.303 |
| R-HSA-109582 | Hemostasis | 0.499466 | 0.301 |
| R-HSA-112399 | IRS-mediated signalling | 0.503281 | 0.298 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.503281 | 0.298 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.504248 | 0.297 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.508610 | 0.294 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.508610 | 0.294 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.508610 | 0.294 |
| R-HSA-72312 | rRNA processing | 0.509531 | 0.293 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.513883 | 0.289 |
| R-HSA-186712 | Regulation of beta-cell development | 0.513883 | 0.289 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.519099 | 0.285 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.519099 | 0.285 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.524260 | 0.280 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.524260 | 0.280 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.524260 | 0.280 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.526914 | 0.278 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.529365 | 0.276 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.529365 | 0.276 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.533421 | 0.273 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.534416 | 0.272 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.534416 | 0.272 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.534416 | 0.272 |
| R-HSA-373755 | Semaphorin interactions | 0.534416 | 0.272 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.539414 | 0.268 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.539414 | 0.268 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.539414 | 0.268 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.539867 | 0.268 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.544358 | 0.264 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.544358 | 0.264 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.549249 | 0.260 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.552575 | 0.258 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.552575 | 0.258 |
| R-HSA-9609646 | HCMV Infection | 0.555961 | 0.255 |
| R-HSA-167172 | Transcription of the HIV genome | 0.558875 | 0.253 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.558875 | 0.253 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.558875 | 0.253 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.568297 | 0.245 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.568297 | 0.245 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.572932 | 0.242 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.572932 | 0.242 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.572932 | 0.242 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.577518 | 0.238 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.577518 | 0.238 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.582055 | 0.235 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.582055 | 0.235 |
| R-HSA-4086398 | Ca2+ pathway | 0.582055 | 0.235 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.583259 | 0.234 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.583259 | 0.234 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.586544 | 0.232 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.586544 | 0.232 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.586544 | 0.232 |
| R-HSA-9679506 | SARS-CoV Infections | 0.587419 | 0.231 |
| R-HSA-380287 | Centrosome maturation | 0.590985 | 0.228 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.590985 | 0.228 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.590985 | 0.228 |
| R-HSA-8852135 | Protein ubiquitination | 0.590985 | 0.228 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.591158 | 0.228 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.604025 | 0.219 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.604025 | 0.219 |
| R-HSA-216083 | Integrin cell surface interactions | 0.604025 | 0.219 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.605878 | 0.218 |
| R-HSA-112316 | Neuronal System | 0.606019 | 0.218 |
| R-HSA-9659379 | Sensory processing of sound | 0.608279 | 0.216 |
| R-HSA-168256 | Immune System | 0.611111 | 0.214 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.612487 | 0.213 |
| R-HSA-6806834 | Signaling by MET | 0.612487 | 0.213 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.615201 | 0.211 |
| R-HSA-977225 | Amyloid fiber formation | 0.616651 | 0.210 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.616651 | 0.210 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.616651 | 0.210 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.620770 | 0.207 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.620770 | 0.207 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.624845 | 0.204 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.628877 | 0.201 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.628877 | 0.201 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.636811 | 0.196 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.636811 | 0.196 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.640715 | 0.193 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.640715 | 0.193 |
| R-HSA-3781865 | Diseases of glycosylation | 0.642594 | 0.192 |
| R-HSA-70268 | Pyruvate metabolism | 0.644577 | 0.191 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.648398 | 0.188 |
| R-HSA-156902 | Peptide chain elongation | 0.648398 | 0.188 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.652178 | 0.186 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.655917 | 0.183 |
| R-HSA-5617833 | Cilium Assembly | 0.658284 | 0.182 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.659617 | 0.181 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.660845 | 0.180 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.663277 | 0.178 |
| R-HSA-68877 | Mitotic Prometaphase | 0.665921 | 0.177 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.666898 | 0.176 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.666898 | 0.176 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.674024 | 0.171 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.677530 | 0.169 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.680998 | 0.167 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.680998 | 0.167 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.691183 | 0.160 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.691183 | 0.160 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.691183 | 0.160 |
| R-HSA-422356 | Regulation of insulin secretion | 0.691183 | 0.160 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.697792 | 0.156 |
| R-HSA-70171 | Glycolysis | 0.697792 | 0.156 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.701044 | 0.154 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.701044 | 0.154 |
| R-HSA-1483255 | PI Metabolism | 0.704261 | 0.152 |
| R-HSA-192823 | Viral mRNA Translation | 0.707443 | 0.150 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.709529 | 0.149 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.710592 | 0.148 |
| R-HSA-111885 | Opioid Signalling | 0.710592 | 0.148 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.713381 | 0.147 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.713706 | 0.146 |
| R-HSA-9833110 | RSV-host interactions | 0.713706 | 0.146 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.716788 | 0.145 |
| R-HSA-211000 | Gene Silencing by RNA | 0.722852 | 0.141 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.725836 | 0.139 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.725836 | 0.139 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.725836 | 0.139 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.725836 | 0.139 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.728788 | 0.137 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.728788 | 0.137 |
| R-HSA-1643685 | Disease | 0.731122 | 0.136 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.737454 | 0.132 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.737454 | 0.132 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.740281 | 0.131 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.748583 | 0.126 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.751291 | 0.124 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.751291 | 0.124 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.753970 | 0.123 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.753970 | 0.123 |
| R-HSA-388396 | GPCR downstream signalling | 0.754930 | 0.122 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.756621 | 0.121 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.756621 | 0.121 |
| R-HSA-70326 | Glucose metabolism | 0.756621 | 0.121 |
| R-HSA-68875 | Mitotic Prophase | 0.764403 | 0.117 |
| R-HSA-8939211 | ESR-mediated signaling | 0.764673 | 0.117 |
| R-HSA-3371556 | Cellular response to heat stress | 0.766941 | 0.115 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.766941 | 0.115 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.774395 | 0.111 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.782865 | 0.106 |
| R-HSA-5688426 | Deubiquitination | 0.796524 | 0.099 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.808255 | 0.092 |
| R-HSA-163685 | Integration of energy metabolism | 0.808255 | 0.092 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.809422 | 0.092 |
| R-HSA-597592 | Post-translational protein modification | 0.809494 | 0.092 |
| R-HSA-68886 | M Phase | 0.809957 | 0.092 |
| R-HSA-5173105 | O-linked glycosylation | 0.810324 | 0.091 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.810324 | 0.091 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.811284 | 0.091 |
| R-HSA-913531 | Interferon Signaling | 0.811284 | 0.091 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.812370 | 0.090 |
| R-HSA-1280218 | Adaptive Immune System | 0.815741 | 0.088 |
| R-HSA-9664407 | Parasite infection | 0.816397 | 0.088 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.816397 | 0.088 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.816397 | 0.088 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.818378 | 0.087 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.822277 | 0.085 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.824195 | 0.084 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.829061 | 0.081 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.831664 | 0.080 |
| R-HSA-2187338 | Visual phototransduction | 0.831664 | 0.080 |
| R-HSA-9758941 | Gastrulation | 0.835280 | 0.078 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.837190 | 0.077 |
| R-HSA-372790 | Signaling by GPCR | 0.837324 | 0.077 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.840558 | 0.075 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.845669 | 0.073 |
| R-HSA-162587 | HIV Life Cycle | 0.848985 | 0.071 |
| R-HSA-382551 | Transport of small molecules | 0.849378 | 0.071 |
| R-HSA-9711097 | Cellular response to starvation | 0.850616 | 0.070 |
| R-HSA-877300 | Interferon gamma signaling | 0.852230 | 0.069 |
| R-HSA-109581 | Apoptosis | 0.856969 | 0.067 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.857269 | 0.067 |
| R-HSA-195721 | Signaling by WNT | 0.857695 | 0.067 |
| R-HSA-72766 | Translation | 0.864406 | 0.063 |
| R-HSA-418555 | G alpha (s) signalling events | 0.871699 | 0.060 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.871699 | 0.060 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.874458 | 0.058 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.877159 | 0.057 |
| R-HSA-168255 | Influenza Infection | 0.882388 | 0.054 |
| R-HSA-392499 | Metabolism of proteins | 0.885579 | 0.053 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.887396 | 0.052 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.891013 | 0.050 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.908436 | 0.042 |
| R-HSA-5357801 | Programmed Cell Death | 0.912341 | 0.040 |
| R-HSA-6805567 | Keratinization | 0.913291 | 0.039 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.919680 | 0.036 |
| R-HSA-162906 | HIV Infection | 0.931036 | 0.031 |
| R-HSA-9824446 | Viral Infection Pathways | 0.931346 | 0.031 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.931784 | 0.031 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.933257 | 0.030 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.936863 | 0.028 |
| R-HSA-15869 | Metabolism of nucleotides | 0.937488 | 0.028 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.938166 | 0.028 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.939092 | 0.027 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.939502 | 0.027 |
| R-HSA-418594 | G alpha (i) signalling events | 0.945836 | 0.024 |
| R-HSA-5668914 | Diseases of metabolism | 0.954848 | 0.020 |
| R-HSA-168249 | Innate Immune System | 0.958333 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.961778 | 0.017 |
| R-HSA-9658195 | Leishmania infection | 0.961778 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 0.967212 | 0.014 |
| R-HSA-199991 | Membrane Trafficking | 0.976361 | 0.010 |
| R-HSA-1474244 | Extracellular matrix organization | 0.977910 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.980208 | 0.009 |
| R-HSA-5663205 | Infectious disease | 0.980459 | 0.009 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.981874 | 0.008 |
| R-HSA-73894 | DNA Repair | 0.983940 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 0.990198 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.992606 | 0.003 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.994204 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.994433 | 0.002 |
| R-HSA-6798695 | Neutrophil degranulation | 0.994555 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.997382 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999788 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999872 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999905 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999945 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.857 | 0.143 | 2 | 0.803 |
CDC7 |
0.854 | 0.151 | 1 | 0.811 |
CLK3 |
0.853 | 0.214 | 1 | 0.767 |
PIM3 |
0.852 | 0.191 | -3 | 0.870 |
MOS |
0.848 | 0.163 | 1 | 0.830 |
CDKL5 |
0.847 | 0.262 | -3 | 0.827 |
SRPK1 |
0.845 | 0.176 | -3 | 0.800 |
HIPK4 |
0.845 | 0.225 | 1 | 0.741 |
NDR2 |
0.844 | 0.113 | -3 | 0.868 |
MTOR |
0.844 | 0.063 | 1 | 0.749 |
CDKL1 |
0.844 | 0.191 | -3 | 0.837 |
PRKD1 |
0.842 | 0.182 | -3 | 0.846 |
ERK5 |
0.842 | 0.179 | 1 | 0.841 |
RSK2 |
0.841 | 0.138 | -3 | 0.814 |
ATR |
0.841 | 0.107 | 1 | 0.814 |
PIM1 |
0.840 | 0.168 | -3 | 0.822 |
CAMK1B |
0.840 | 0.089 | -3 | 0.880 |
ICK |
0.839 | 0.227 | -3 | 0.866 |
PRPK |
0.839 | -0.058 | -1 | 0.804 |
SKMLCK |
0.838 | 0.113 | -2 | 0.815 |
RAF1 |
0.837 | -0.040 | 1 | 0.806 |
IKKB |
0.836 | -0.058 | -2 | 0.699 |
GCN2 |
0.835 | -0.080 | 2 | 0.731 |
PRKD2 |
0.835 | 0.133 | -3 | 0.806 |
P90RSK |
0.834 | 0.101 | -3 | 0.813 |
TBK1 |
0.834 | -0.033 | 1 | 0.710 |
NLK |
0.834 | 0.031 | 1 | 0.783 |
PKN3 |
0.834 | 0.062 | -3 | 0.842 |
CAMK2G |
0.834 | -0.033 | 2 | 0.743 |
PDHK4 |
0.834 | -0.153 | 1 | 0.806 |
NDR1 |
0.834 | 0.060 | -3 | 0.860 |
KIS |
0.833 | 0.074 | 1 | 0.655 |
CAMK2D |
0.833 | 0.081 | -3 | 0.844 |
DSTYK |
0.833 | -0.024 | 2 | 0.823 |
WNK1 |
0.832 | 0.064 | -2 | 0.830 |
MAPKAPK2 |
0.832 | 0.120 | -3 | 0.779 |
NUAK2 |
0.832 | 0.081 | -3 | 0.857 |
DYRK2 |
0.832 | 0.136 | 1 | 0.668 |
RSK3 |
0.832 | 0.084 | -3 | 0.806 |
BMPR2 |
0.832 | -0.099 | -2 | 0.836 |
NEK6 |
0.831 | 0.003 | -2 | 0.812 |
GRK5 |
0.831 | -0.040 | -3 | 0.848 |
CAMLCK |
0.830 | 0.047 | -2 | 0.799 |
FAM20C |
0.830 | 0.090 | 2 | 0.581 |
NIK |
0.830 | 0.028 | -3 | 0.885 |
GRK1 |
0.830 | 0.073 | -2 | 0.733 |
CLK2 |
0.830 | 0.195 | -3 | 0.796 |
MAPKAPK3 |
0.830 | 0.092 | -3 | 0.801 |
MST4 |
0.830 | 0.026 | 2 | 0.781 |
DAPK2 |
0.830 | 0.065 | -3 | 0.875 |
AMPKA1 |
0.830 | 0.075 | -3 | 0.863 |
LATS2 |
0.830 | 0.049 | -5 | 0.788 |
AURC |
0.829 | 0.091 | -2 | 0.601 |
CHAK2 |
0.829 | 0.027 | -1 | 0.762 |
HUNK |
0.829 | 0.017 | 2 | 0.766 |
IKKE |
0.829 | -0.084 | 1 | 0.703 |
SRPK2 |
0.829 | 0.124 | -3 | 0.727 |
BMPR1B |
0.828 | 0.137 | 1 | 0.782 |
MARK4 |
0.828 | 0.039 | 4 | 0.809 |
CAMK2B |
0.828 | 0.086 | 2 | 0.718 |
RIPK3 |
0.828 | -0.023 | 3 | 0.659 |
TGFBR2 |
0.828 | -0.014 | -2 | 0.748 |
CDK8 |
0.828 | 0.082 | 1 | 0.611 |
SRPK3 |
0.828 | 0.123 | -3 | 0.771 |
GRK6 |
0.827 | 0.020 | 1 | 0.797 |
CDK19 |
0.827 | 0.105 | 1 | 0.576 |
PKN2 |
0.827 | 0.040 | -3 | 0.848 |
PDHK1 |
0.827 | -0.161 | 1 | 0.789 |
CAMK2A |
0.827 | 0.099 | 2 | 0.733 |
AMPKA2 |
0.827 | 0.090 | -3 | 0.840 |
ULK2 |
0.826 | -0.147 | 2 | 0.709 |
LATS1 |
0.825 | 0.111 | -3 | 0.877 |
GRK7 |
0.825 | 0.099 | 1 | 0.741 |
TSSK1 |
0.825 | 0.095 | -3 | 0.876 |
PKACG |
0.825 | 0.039 | -2 | 0.684 |
MASTL |
0.824 | -0.101 | -2 | 0.770 |
IKKA |
0.824 | -0.020 | -2 | 0.699 |
CDK18 |
0.824 | 0.112 | 1 | 0.573 |
TGFBR1 |
0.824 | 0.084 | -2 | 0.762 |
PKCD |
0.823 | 0.032 | 2 | 0.700 |
MLK1 |
0.823 | -0.082 | 2 | 0.735 |
P70S6KB |
0.823 | 0.036 | -3 | 0.823 |
P38A |
0.823 | 0.147 | 1 | 0.696 |
HIPK2 |
0.823 | 0.142 | 1 | 0.580 |
JNK2 |
0.823 | 0.103 | 1 | 0.581 |
BCKDK |
0.823 | -0.111 | -1 | 0.757 |
RSK4 |
0.823 | 0.100 | -3 | 0.791 |
NEK7 |
0.823 | -0.127 | -3 | 0.823 |
PKACB |
0.822 | 0.095 | -2 | 0.620 |
ATM |
0.822 | 0.024 | 1 | 0.764 |
TSSK2 |
0.822 | 0.053 | -5 | 0.902 |
NIM1 |
0.822 | 0.018 | 3 | 0.722 |
P38B |
0.822 | 0.141 | 1 | 0.626 |
CLK1 |
0.821 | 0.113 | -3 | 0.786 |
CLK4 |
0.821 | 0.092 | -3 | 0.803 |
PAK1 |
0.821 | 0.030 | -2 | 0.753 |
MLK2 |
0.821 | -0.000 | 2 | 0.745 |
ALK4 |
0.820 | 0.031 | -2 | 0.790 |
CDK7 |
0.820 | 0.049 | 1 | 0.633 |
GRK4 |
0.820 | -0.078 | -2 | 0.779 |
PAK6 |
0.819 | 0.113 | -2 | 0.656 |
MSK1 |
0.819 | 0.073 | -3 | 0.783 |
HIPK1 |
0.819 | 0.128 | 1 | 0.682 |
DNAPK |
0.819 | 0.078 | 1 | 0.712 |
DLK |
0.819 | -0.103 | 1 | 0.786 |
CDK1 |
0.818 | 0.059 | 1 | 0.592 |
MAK |
0.818 | 0.297 | -2 | 0.828 |
QSK |
0.818 | 0.055 | 4 | 0.782 |
PIM2 |
0.818 | 0.126 | -3 | 0.783 |
MPSK1 |
0.818 | 0.294 | 1 | 0.797 |
CDK5 |
0.818 | 0.076 | 1 | 0.654 |
PRKD3 |
0.817 | 0.081 | -3 | 0.783 |
JNK3 |
0.817 | 0.062 | 1 | 0.612 |
NEK9 |
0.817 | -0.102 | 2 | 0.767 |
MNK2 |
0.817 | 0.032 | -2 | 0.731 |
ERK1 |
0.817 | 0.095 | 1 | 0.614 |
IRE1 |
0.817 | -0.024 | 1 | 0.773 |
PKCB |
0.817 | 0.035 | 2 | 0.662 |
PRKX |
0.817 | 0.106 | -3 | 0.729 |
DYRK4 |
0.817 | 0.113 | 1 | 0.590 |
AKT2 |
0.816 | 0.098 | -3 | 0.734 |
MSK2 |
0.816 | 0.020 | -3 | 0.783 |
PKR |
0.816 | 0.024 | 1 | 0.808 |
SGK3 |
0.816 | 0.092 | -3 | 0.791 |
PLK1 |
0.816 | -0.035 | -2 | 0.755 |
MLK3 |
0.816 | -0.017 | 2 | 0.666 |
CHK1 |
0.815 | 0.081 | -3 | 0.837 |
CAMK4 |
0.815 | -0.037 | -3 | 0.831 |
ACVR2B |
0.815 | 0.041 | -2 | 0.760 |
NUAK1 |
0.815 | 0.026 | -3 | 0.817 |
PKCA |
0.815 | 0.035 | 2 | 0.649 |
RIPK1 |
0.815 | -0.124 | 1 | 0.798 |
DYRK1A |
0.815 | 0.124 | 1 | 0.686 |
PAK3 |
0.815 | -0.017 | -2 | 0.743 |
ANKRD3 |
0.815 | -0.139 | 1 | 0.839 |
MELK |
0.815 | 0.022 | -3 | 0.821 |
PKCG |
0.815 | 0.015 | 2 | 0.661 |
CDK13 |
0.814 | 0.024 | 1 | 0.606 |
TLK2 |
0.814 | -0.004 | 1 | 0.753 |
SMG1 |
0.814 | 0.005 | 1 | 0.771 |
ULK1 |
0.814 | -0.197 | -3 | 0.790 |
P38G |
0.814 | 0.069 | 1 | 0.510 |
MNK1 |
0.814 | 0.028 | -2 | 0.735 |
AURB |
0.813 | 0.031 | -2 | 0.601 |
TTBK2 |
0.813 | -0.128 | 2 | 0.669 |
WNK3 |
0.813 | -0.215 | 1 | 0.778 |
ACVR2A |
0.813 | 0.017 | -2 | 0.746 |
MYLK4 |
0.812 | 0.025 | -2 | 0.715 |
PLK3 |
0.812 | -0.021 | 2 | 0.713 |
SIK |
0.812 | 0.034 | -3 | 0.789 |
VRK2 |
0.812 | -0.084 | 1 | 0.824 |
QIK |
0.811 | -0.035 | -3 | 0.834 |
ALK2 |
0.811 | 0.024 | -2 | 0.764 |
MEK1 |
0.811 | -0.102 | 2 | 0.770 |
YSK4 |
0.811 | -0.085 | 1 | 0.741 |
DCAMKL1 |
0.811 | 0.061 | -3 | 0.816 |
GSK3A |
0.811 | 0.145 | 4 | 0.593 |
PKG2 |
0.811 | 0.034 | -2 | 0.620 |
PKCZ |
0.811 | 0.003 | 2 | 0.711 |
MARK3 |
0.810 | 0.028 | 4 | 0.737 |
P38D |
0.810 | 0.097 | 1 | 0.538 |
PHKG1 |
0.810 | -0.017 | -3 | 0.842 |
PASK |
0.810 | 0.104 | -3 | 0.878 |
CDK12 |
0.810 | 0.028 | 1 | 0.579 |
GSK3B |
0.809 | 0.117 | 4 | 0.588 |
AURA |
0.809 | 0.008 | -2 | 0.574 |
HIPK3 |
0.809 | 0.091 | 1 | 0.688 |
CDK17 |
0.808 | 0.043 | 1 | 0.515 |
MLK4 |
0.808 | -0.064 | 2 | 0.646 |
BRSK1 |
0.808 | -0.015 | -3 | 0.816 |
GRK2 |
0.808 | -0.017 | -2 | 0.687 |
DYRK3 |
0.807 | 0.096 | 1 | 0.686 |
PKCH |
0.807 | -0.025 | 2 | 0.642 |
CDK14 |
0.807 | 0.070 | 1 | 0.616 |
CDK3 |
0.807 | 0.053 | 1 | 0.538 |
IRE2 |
0.807 | -0.060 | 2 | 0.664 |
PAK2 |
0.807 | -0.047 | -2 | 0.731 |
BMPR1A |
0.807 | 0.067 | 1 | 0.749 |
DRAK1 |
0.806 | -0.021 | 1 | 0.788 |
NEK2 |
0.806 | -0.073 | 2 | 0.751 |
PKACA |
0.806 | 0.069 | -2 | 0.570 |
CDK9 |
0.805 | -0.005 | 1 | 0.617 |
MARK2 |
0.805 | -0.007 | 4 | 0.703 |
CDK16 |
0.805 | 0.077 | 1 | 0.531 |
CAMK1G |
0.805 | 0.015 | -3 | 0.786 |
MOK |
0.805 | 0.232 | 1 | 0.742 |
DYRK1B |
0.804 | 0.061 | 1 | 0.622 |
PERK |
0.804 | -0.064 | -2 | 0.775 |
CHAK1 |
0.804 | -0.116 | 2 | 0.722 |
BRSK2 |
0.803 | -0.064 | -3 | 0.826 |
MST3 |
0.803 | 0.011 | 2 | 0.780 |
CDK10 |
0.803 | 0.070 | 1 | 0.605 |
GAK |
0.803 | 0.168 | 1 | 0.866 |
WNK4 |
0.803 | -0.030 | -2 | 0.830 |
PLK4 |
0.802 | -0.085 | 2 | 0.572 |
CK2A2 |
0.802 | 0.076 | 1 | 0.690 |
BRAF |
0.801 | -0.099 | -4 | 0.778 |
ERK2 |
0.801 | -0.004 | 1 | 0.638 |
MARK1 |
0.801 | -0.020 | 4 | 0.751 |
PRP4 |
0.801 | 0.001 | -3 | 0.751 |
MAPKAPK5 |
0.801 | -0.046 | -3 | 0.733 |
CK1E |
0.800 | -0.006 | -3 | 0.540 |
CDK2 |
0.800 | -0.044 | 1 | 0.671 |
HRI |
0.800 | -0.124 | -2 | 0.806 |
TLK1 |
0.800 | -0.090 | -2 | 0.793 |
NEK5 |
0.799 | -0.049 | 1 | 0.817 |
AKT1 |
0.799 | 0.059 | -3 | 0.746 |
TAO3 |
0.799 | -0.024 | 1 | 0.762 |
DCAMKL2 |
0.799 | -0.005 | -3 | 0.835 |
SMMLCK |
0.799 | -0.004 | -3 | 0.838 |
ERK7 |
0.798 | 0.057 | 2 | 0.515 |
CAMK1D |
0.798 | 0.050 | -3 | 0.730 |
MEKK2 |
0.798 | -0.096 | 2 | 0.725 |
PAK5 |
0.798 | 0.035 | -2 | 0.600 |
MEK5 |
0.798 | -0.202 | 2 | 0.747 |
MEKK3 |
0.798 | -0.147 | 1 | 0.778 |
DAPK3 |
0.798 | 0.050 | -3 | 0.830 |
JNK1 |
0.798 | 0.036 | 1 | 0.563 |
GRK3 |
0.798 | -0.006 | -2 | 0.644 |
MEKK1 |
0.798 | -0.142 | 1 | 0.771 |
PAK4 |
0.797 | 0.051 | -2 | 0.605 |
BUB1 |
0.796 | 0.166 | -5 | 0.866 |
P70S6K |
0.795 | 0.006 | -3 | 0.737 |
ZAK |
0.795 | -0.169 | 1 | 0.735 |
EEF2K |
0.795 | 0.046 | 3 | 0.784 |
PINK1 |
0.795 | -0.145 | 1 | 0.786 |
PKCT |
0.794 | -0.029 | 2 | 0.648 |
GCK |
0.794 | 0.014 | 1 | 0.776 |
SGK1 |
0.794 | 0.088 | -3 | 0.665 |
PLK2 |
0.794 | 0.027 | -3 | 0.816 |
PDK1 |
0.794 | -0.001 | 1 | 0.787 |
DAPK1 |
0.794 | 0.046 | -3 | 0.812 |
SNRK |
0.794 | -0.183 | 2 | 0.608 |
LKB1 |
0.794 | 0.004 | -3 | 0.801 |
SSTK |
0.794 | -0.030 | 4 | 0.771 |
CK2A1 |
0.793 | 0.072 | 1 | 0.670 |
PHKG2 |
0.793 | -0.042 | -3 | 0.813 |
AKT3 |
0.793 | 0.078 | -3 | 0.683 |
PKCE |
0.793 | 0.024 | 2 | 0.651 |
IRAK4 |
0.792 | -0.104 | 1 | 0.781 |
PBK |
0.792 | 0.171 | 1 | 0.824 |
PKCI |
0.792 | -0.017 | 2 | 0.676 |
TNIK |
0.791 | 0.035 | 3 | 0.814 |
CK1G1 |
0.791 | -0.048 | -3 | 0.551 |
CK1D |
0.790 | -0.027 | -3 | 0.488 |
HPK1 |
0.789 | 0.011 | 1 | 0.768 |
HGK |
0.789 | -0.009 | 3 | 0.802 |
TAO2 |
0.788 | -0.093 | 2 | 0.770 |
MINK |
0.788 | -0.021 | 1 | 0.765 |
NEK11 |
0.788 | -0.149 | 1 | 0.769 |
ROCK2 |
0.788 | 0.069 | -3 | 0.814 |
CK1A2 |
0.788 | -0.029 | -3 | 0.489 |
PKN1 |
0.788 | 0.032 | -3 | 0.750 |
MST2 |
0.787 | -0.085 | 1 | 0.781 |
MEKK6 |
0.787 | -0.032 | 1 | 0.767 |
CDK6 |
0.787 | 0.028 | 1 | 0.599 |
CHK2 |
0.787 | 0.053 | -3 | 0.684 |
NEK8 |
0.787 | -0.169 | 2 | 0.742 |
KHS1 |
0.786 | 0.044 | 1 | 0.754 |
MAP3K15 |
0.786 | -0.046 | 1 | 0.731 |
CAMK1A |
0.786 | 0.056 | -3 | 0.713 |
CAMKK1 |
0.786 | -0.158 | -2 | 0.687 |
CAMKK2 |
0.786 | -0.107 | -2 | 0.684 |
SBK |
0.786 | 0.086 | -3 | 0.628 |
MRCKB |
0.786 | 0.045 | -3 | 0.771 |
KHS2 |
0.785 | 0.049 | 1 | 0.765 |
NEK4 |
0.785 | -0.093 | 1 | 0.768 |
CDK4 |
0.784 | 0.024 | 1 | 0.562 |
PDHK3_TYR |
0.784 | 0.239 | 4 | 0.885 |
MRCKA |
0.784 | 0.028 | -3 | 0.787 |
LRRK2 |
0.784 | -0.089 | 2 | 0.779 |
NEK1 |
0.783 | -0.024 | 1 | 0.783 |
TTBK1 |
0.783 | -0.182 | 2 | 0.585 |
TAK1 |
0.783 | -0.101 | 1 | 0.782 |
DMPK1 |
0.782 | 0.089 | -3 | 0.800 |
VRK1 |
0.782 | -0.087 | 2 | 0.775 |
IRAK1 |
0.781 | -0.240 | -1 | 0.697 |
LOK |
0.779 | -0.075 | -2 | 0.700 |
MST1 |
0.778 | -0.116 | 1 | 0.761 |
YSK1 |
0.776 | -0.059 | 2 | 0.739 |
HASPIN |
0.775 | 0.060 | -1 | 0.699 |
MAP2K6_TYR |
0.775 | 0.076 | -1 | 0.828 |
MAP2K4_TYR |
0.775 | 0.072 | -1 | 0.823 |
BIKE |
0.775 | 0.151 | 1 | 0.789 |
CRIK |
0.774 | 0.061 | -3 | 0.753 |
PDHK4_TYR |
0.773 | 0.051 | 2 | 0.801 |
MEK2 |
0.773 | -0.190 | 2 | 0.742 |
BMPR2_TYR |
0.772 | 0.045 | -1 | 0.823 |
TESK1_TYR |
0.772 | -0.029 | 3 | 0.824 |
SLK |
0.772 | -0.125 | -2 | 0.653 |
PKMYT1_TYR |
0.771 | 0.020 | 3 | 0.782 |
ROCK1 |
0.771 | 0.027 | -3 | 0.781 |
STK33 |
0.770 | -0.166 | 2 | 0.558 |
LIMK2_TYR |
0.770 | 0.079 | -3 | 0.885 |
OSR1 |
0.769 | -0.085 | 2 | 0.721 |
PKG1 |
0.769 | -0.011 | -2 | 0.537 |
PDHK1_TYR |
0.769 | -0.000 | -1 | 0.816 |
TTK |
0.768 | -0.056 | -2 | 0.772 |
MAP2K7_TYR |
0.767 | -0.149 | 2 | 0.786 |
NEK3 |
0.767 | -0.112 | 1 | 0.735 |
MYO3B |
0.766 | -0.023 | 2 | 0.756 |
AAK1 |
0.766 | 0.203 | 1 | 0.711 |
EPHA6 |
0.764 | 0.020 | -1 | 0.781 |
PINK1_TYR |
0.764 | -0.157 | 1 | 0.800 |
RIPK2 |
0.763 | -0.285 | 1 | 0.714 |
YANK3 |
0.763 | -0.069 | 2 | 0.378 |
EPHB4 |
0.763 | 0.014 | -1 | 0.747 |
ABL2 |
0.762 | 0.060 | -1 | 0.727 |
FGR |
0.761 | 0.026 | 1 | 0.856 |
ASK1 |
0.760 | -0.148 | 1 | 0.713 |
TXK |
0.759 | 0.077 | 1 | 0.815 |
RET |
0.759 | -0.126 | 1 | 0.766 |
ABL1 |
0.758 | 0.051 | -1 | 0.718 |
TNK2 |
0.758 | 0.048 | 3 | 0.655 |
LCK |
0.758 | 0.090 | -1 | 0.755 |
LIMK1_TYR |
0.757 | -0.140 | 2 | 0.777 |
CK1A |
0.757 | -0.042 | -3 | 0.403 |
MYO3A |
0.757 | -0.102 | 1 | 0.741 |
YES1 |
0.757 | -0.005 | -1 | 0.756 |
BLK |
0.756 | 0.099 | -1 | 0.757 |
TYK2 |
0.756 | -0.156 | 1 | 0.765 |
TAO1 |
0.755 | -0.125 | 1 | 0.691 |
MST1R |
0.755 | -0.134 | 3 | 0.726 |
DDR1 |
0.754 | -0.128 | 4 | 0.806 |
TYRO3 |
0.754 | -0.127 | 3 | 0.710 |
ALPHAK3 |
0.754 | -0.111 | -1 | 0.703 |
HCK |
0.754 | -0.004 | -1 | 0.752 |
ROS1 |
0.754 | -0.115 | 3 | 0.674 |
SRMS |
0.753 | -0.031 | 1 | 0.820 |
JAK2 |
0.753 | -0.142 | 1 | 0.757 |
EPHA4 |
0.753 | -0.036 | 2 | 0.720 |
ITK |
0.753 | -0.012 | -1 | 0.722 |
CSF1R |
0.752 | -0.103 | 3 | 0.689 |
FER |
0.752 | -0.118 | 1 | 0.837 |
EPHB1 |
0.751 | -0.059 | 1 | 0.820 |
FYN |
0.751 | 0.064 | -1 | 0.742 |
TNNI3K_TYR |
0.750 | 0.001 | 1 | 0.767 |
INSRR |
0.749 | -0.125 | 3 | 0.652 |
EPHB3 |
0.749 | -0.056 | -1 | 0.732 |
EPHB2 |
0.749 | -0.042 | -1 | 0.720 |
JAK3 |
0.749 | -0.144 | 1 | 0.750 |
BMX |
0.748 | -0.017 | -1 | 0.649 |
TNK1 |
0.748 | -0.044 | 3 | 0.701 |
MERTK |
0.746 | -0.067 | 3 | 0.686 |
JAK1 |
0.746 | -0.060 | 1 | 0.713 |
NEK10_TYR |
0.745 | -0.108 | 1 | 0.652 |
FGFR2 |
0.743 | -0.195 | 3 | 0.708 |
STLK3 |
0.743 | -0.234 | 1 | 0.704 |
KIT |
0.743 | -0.161 | 3 | 0.691 |
FLT3 |
0.742 | -0.175 | 3 | 0.706 |
PTK6 |
0.742 | -0.154 | -1 | 0.653 |
TEC |
0.742 | -0.088 | -1 | 0.644 |
AXL |
0.741 | -0.134 | 3 | 0.678 |
MET |
0.741 | -0.113 | 3 | 0.692 |
PDGFRB |
0.741 | -0.223 | 3 | 0.706 |
BTK |
0.741 | -0.153 | -1 | 0.683 |
EPHA3 |
0.740 | -0.105 | 2 | 0.689 |
EPHA7 |
0.740 | -0.075 | 2 | 0.714 |
KDR |
0.740 | -0.167 | 3 | 0.654 |
LYN |
0.740 | -0.044 | 3 | 0.622 |
PTK2B |
0.739 | -0.038 | -1 | 0.685 |
WEE1_TYR |
0.739 | -0.110 | -1 | 0.677 |
PTK2 |
0.738 | 0.037 | -1 | 0.735 |
NTRK1 |
0.737 | -0.202 | -1 | 0.741 |
LTK |
0.737 | -0.146 | 3 | 0.630 |
FRK |
0.737 | -0.100 | -1 | 0.751 |
SRC |
0.737 | -0.030 | -1 | 0.728 |
EPHA1 |
0.737 | -0.113 | 3 | 0.668 |
DDR2 |
0.736 | -0.052 | 3 | 0.621 |
PDGFRA |
0.735 | -0.242 | 3 | 0.704 |
EPHA5 |
0.735 | -0.082 | 2 | 0.699 |
ALK |
0.735 | -0.191 | 3 | 0.605 |
FGFR1 |
0.735 | -0.243 | 3 | 0.668 |
NTRK3 |
0.734 | -0.141 | -1 | 0.704 |
INSR |
0.734 | -0.165 | 3 | 0.638 |
TEK |
0.734 | -0.237 | 3 | 0.633 |
FLT1 |
0.734 | -0.165 | -1 | 0.752 |
EPHA8 |
0.733 | -0.082 | -1 | 0.726 |
FGFR3 |
0.731 | -0.214 | 3 | 0.677 |
ERBB2 |
0.731 | -0.209 | 1 | 0.712 |
NTRK2 |
0.731 | -0.238 | 3 | 0.656 |
SYK |
0.731 | -0.016 | -1 | 0.720 |
CSK |
0.730 | -0.125 | 2 | 0.717 |
EGFR |
0.729 | -0.113 | 1 | 0.621 |
YANK2 |
0.729 | -0.100 | 2 | 0.382 |
FLT4 |
0.727 | -0.242 | 3 | 0.654 |
MATK |
0.727 | -0.154 | -1 | 0.649 |
CK1G3 |
0.725 | -0.098 | -3 | 0.361 |
EPHA2 |
0.723 | -0.096 | -1 | 0.696 |
FGFR4 |
0.723 | -0.154 | -1 | 0.681 |
IGF1R |
0.720 | -0.162 | 3 | 0.578 |
MUSK |
0.718 | -0.172 | 1 | 0.640 |
ERBB4 |
0.717 | -0.095 | 1 | 0.643 |
CK1G2 |
0.714 | -0.078 | -3 | 0.459 |
FES |
0.705 | -0.169 | -1 | 0.620 |
ZAP70 |
0.704 | -0.078 | -1 | 0.661 |