Motif 275 (n=58)

Position-wise Probabilities

Download

uniprot	genes	site	source	protein	function
A0A0C4DFX4	None	S2663	ochoa	Snf2 related CREBBP activator protein	None
A6NFI3	ZNF316	S221	ochoa	Zinc finger protein 316	May be involved in transcriptional regulation. {ECO:0000250}.
A6NI72	NCF1B	S349	ochoa	Putative neutrophil cytosol factor 1B (NCF-1B) (Putative SH3 and PX domain-containing protein 1B)	May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.
A8MVU1	NCF1C	S324	ochoa	Putative neutrophil cytosol factor 1C (NCF-1C) (Putative SH3 and PX domain-containing protein 1C)	May be required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250}.
O15020	SPTBN2	S2359	ochoa	Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)	Probably plays an important role in neuronal membrane skeleton.
P05023	ATP1A1	S216	ochoa	Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250\|UniProtKB:Q8VDN2, ECO:0000269\|PubMed:29499166, ECO:0000269\|PubMed:30388404}.
P06732	CKM	S199	ochoa	Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250\|UniProtKB:P00563}.
P0C1Z6	TFPT	S180	ochoa\|psp	TCF3 fusion partner (INO80 complex subunit F) (Protein FB1)	Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
P0DSO3	GAGE4	T40	ochoa	G antigen 4 (Cancer/testis antigen 4.4) (CT4.4)	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269\|PubMed:7544395}.
P0DTW1	GAGE1	T40	ochoa	G antigen 1 (GAGE-1) (Antigen MZ2-F) (Cancer/testis antigen 4.1) (CT4.1)	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269\|PubMed:7544395}.
P12277	CKB	S199	ochoa	Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250\|UniProtKB:Q04447, ECO:0000269\|PubMed:8186255, ECO:0000305}.
P13637	ATP1A3	S206	ochoa	Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269\|PubMed:33880529}.
P14598	NCF1	S348	ochoa\|psp	Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)	Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269\|PubMed:12732142, ECO:0000269\|PubMed:19801500, ECO:0000269\|PubMed:2547247, ECO:0000269\|PubMed:2550933, ECO:0000269\|PubMed:38355798}.
P17540	CKMT2	S233	ochoa	Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P20648	ATP4A	S227	ochoa	Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)	The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250\|UniProtKB:P09626, ECO:0000250\|UniProtKB:P19156, ECO:0000250\|UniProtKB:Q64436}.
P22415	USF1	S186	psp	Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)	Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
P25100	ADRA1D	T477	psp	Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a)	This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
P35520	CBS	S32	ochoa	Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250\|UniProtKB:P32232, ECO:0000269\|PubMed:20506325, ECO:0000269\|PubMed:23974653, ECO:0000269\|PubMed:23981774}.
P38936	CDKN1A	S130	ochoa\|psp	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)	Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250\|UniProtKB:P39689, ECO:0000269\|PubMed:11595739, ECO:0000269\|PubMed:8242751, ECO:0000269\|PubMed:9106657}.
P42695	NCAPD3	S1329	ochoa	Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269\|PubMed:14532007, ECO:0000269\|PubMed:27737959}.
P49069	CAMLG	S55	ochoa	Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand)	Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250\|UniProtKB:P49070, ECO:0000269\|PubMed:23041287, ECO:0000269\|PubMed:24392163, ECO:0000269\|PubMed:27226539, ECO:0000269\|PubMed:32187542, ECO:0000269\|PubMed:7522304}.
P50993	ATP1A2	S214	ochoa	Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2)	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269\|PubMed:33880529}.
P56182	RRP1	S383	ochoa	Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)	Plays a critical role in the generation of 28S rRNA. {ECO:0000269\|PubMed:10341208}.
P67809	YBX1	S174	ochoa\|psp	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250\|UniProtKB:P62960, ECO:0000250\|UniProtKB:Q28618, ECO:0000269\|PubMed:10817758, ECO:0000269\|PubMed:11698476, ECO:0000269\|PubMed:12604611, ECO:0000269\|PubMed:14718551, ECO:0000269\|PubMed:18809583, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:19483673, ECO:0000269\|PubMed:19561594, ECO:0000269\|PubMed:27559612, ECO:0000269\|PubMed:28341602, ECO:0000269\|PubMed:29073095, ECO:0000269\|PubMed:29712925, ECO:0000269\|PubMed:31358969, ECO:0000269\|PubMed:8188694}.
Q08050	FOXM1	S331	ochoa\|psp	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)	Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269\|PubMed:17101782, ECO:0000269\|PubMed:19160488, ECO:0000269\|PubMed:20360045, ECO:0000269\|PubMed:33754036}.
Q13066	GAGE2B	T39	ochoa	G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C)	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.
Q13069	GAGE5	T40	ochoa	G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5)	None
Q13070	GAGE6	T40	ochoa	G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6)	None
Q14160	SCRIB	S504	ochoa	Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)	Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250\|UniProtKB:A0A8P0N4K0, ECO:0000250\|UniProtKB:Q80U72, ECO:0000269\|PubMed:15182672, ECO:0000269\|PubMed:16344308, ECO:0000269\|PubMed:16965391, ECO:0000269\|PubMed:18641685, ECO:0000269\|PubMed:18716323, ECO:0000269\|PubMed:19041750, ECO:0000269\|PubMed:27380321}.
Q14676	MDC1	S793	ochoa	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q15464	SHB	S388	ochoa	SH2 domain-containing adapter protein B	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269\|PubMed:10828022, ECO:0000269\|PubMed:10837138, ECO:0000269\|PubMed:12084069, ECO:0000269\|PubMed:12464388, ECO:0000269\|PubMed:12520086, ECO:0000269\|PubMed:15026417, ECO:0000269\|PubMed:15919073, ECO:0000269\|PubMed:8806685, ECO:0000269\|PubMed:9484780, ECO:0000269\|PubMed:9751119}.
Q15853	USF2	S222	psp	Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)	Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Q17RS7	GEN1	S269	ochoa	Flap endonuclease GEN homolog 1 (EC 3.1.-.-)	Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Also has endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). {ECO:0000269\|PubMed:19020614, ECO:0000269\|PubMed:26578604, ECO:0000269\|PubMed:26682650, ECO:0000269\|PubMed:28049850}.
Q5T011	SZT2	S1825	ochoa	KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250\|UniProtKB:A2A9C3, ECO:0000269\|PubMed:28199306, ECO:0000269\|PubMed:28199315}.
Q5T6C5	ATXN7L2	S213	ochoa	Ataxin-7-like protein 2	None
Q5UE93	PIK3R6	S358	ochoa\|psp	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)	Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269\|PubMed:21393242}.
Q6IPM2	IQCE	S598	ochoa	IQ domain-containing protein E	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250\|UniProtKB:Q6PCQ0, ECO:0000269\|PubMed:28488682}.
Q6NT46	GAGE2A	T39	ochoa	G antigen 2A (GAGE-2A)	None
Q6NYC8	PPP1R18	S133	ochoa	Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)	[Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269\|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269\|PubMed:17374523}.
Q6PJ61	FBXO46	S293	ochoa	F-box only protein 46 (F-box only protein 34-like)	Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269\|PubMed:30171069}.
Q6UXY8	TMC5	S184	ochoa	Transmembrane channel-like protein 5	Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}.
Q6ZRS2	SRCAP	S2840	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q765P7	MTSS2	Y655	ochoa	Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein)	Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269\|PubMed:14752106}.
Q76NI1	KNDC1	S392	ochoa	Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)	RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250\|UniProtKB:Q0KK55, ECO:0000269\|PubMed:24788352}.
Q86VQ1	GLCCI1	S148	ochoa	Glucocorticoid-induced transcript 1 protein	None
Q8IU68	TMC8	S683	ochoa	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2)	Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269\|PubMed:18158319, ECO:0000269\|PubMed:23429285, ECO:0000269\|PubMed:25220380, ECO:0000269\|PubMed:30068544, ECO:0000269\|PubMed:32917726}.
Q8IX07	ZFPM1	S84	ochoa	Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IZT6	ASPM	S225	ochoa	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)	Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269\|PubMed:12355089, ECO:0000269\|PubMed:15972725, ECO:0000269\|PubMed:28436967}.
Q8N8E2	ZNF513	S253	ochoa	Zinc finger protein 513	Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269\|PubMed:20797688}.
Q8WZ73	RFFL	S39	ochoa	E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269\|PubMed:15069192, ECO:0000269\|PubMed:17121812, ECO:0000269\|PubMed:18382127, ECO:0000269\|PubMed:18450452, ECO:0000269\|PubMed:22609986}.
Q92797	SYMPK	S510	ochoa	Symplekin	Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269\|PubMed:16230528, ECO:0000269\|PubMed:20861839}.
Q96G74	OTUD5	S165	ochoa	OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269\|PubMed:17991829, ECO:0000269\|PubMed:22245969, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:33110214, ECO:0000269\|PubMed:33523931}.
Q96KM6	ZNF512B	S63	ochoa	Zinc finger protein 512B	Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269\|PubMed:39460621}.
Q9BV73	CEP250	S2259	ochoa	Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)	Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269\|PubMed:28005958, ECO:0000269\|PubMed:30404835, ECO:0000269\|PubMed:36282799}.
Q9UET6	FTSJ1	S271	ochoa	tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1)	Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269\|PubMed:25404562, ECO:0000269\|PubMed:26310293, ECO:0000269\|PubMed:32198346, ECO:0000269\|PubMed:32393790, ECO:0000269\|PubMed:32558197, ECO:0000269\|PubMed:33771871, ECO:0000269\|PubMed:36720500}.
Q9UEU5	GAGE2D;	T39	ochoa	G antigen 2D (GAGE-2D) (Cancer/testis antigen 4.8) (CT4.8) (G antigen 8) (GAGE-8)	None
Q9UKS6	PACSIN3	S344	ochoa	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)	Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11082044}.
Q9Y4B5	MTCL1	T315	ochoa	Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)	Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269\|PubMed:23902687, ECO:0000269\|PubMed:33587225}.

Download

reactome_id	name	p	-log10_p
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.000002	5.654
R-HSA-69895	Transcriptional activation of cell cycle inhibitor p21	0.000002	5.654
R-HSA-936837	Ion transport by P-type ATPases	0.000012	4.928
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.000079	4.102
R-HSA-71288	Creatine metabolism	0.000152	3.818
R-HSA-5578775	Ion homeostasis	0.000139	3.856
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.000190	3.720
R-HSA-8866911	TFAP2 (AP-2) family regulates transcription of cell cycle factors	0.000284	3.546
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.000503	3.299
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.001644	2.784
R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.001644	2.784
R-HSA-983712	Ion channel transport	0.001561	2.807
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.002383	2.623
R-HSA-69615	G1/S DNA Damage Checkpoints	0.003053	2.515
R-HSA-9702518	STAT5 activation downstream of FLT3 ITD mutants	0.003349	2.475
R-HSA-5576891	Cardiac conduction	0.003019	2.520
R-HSA-3700989	Transcriptional Regulation by TP53	0.003434	2.464
R-HSA-9679191	Potential therapeutics for SARS	0.004837	2.315
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.005199	2.284
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.005451	2.263
R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	0.006678	2.175
R-HSA-9703465	Signaling by FLT3 fusion proteins	0.007559	2.122
R-HSA-9614085	FOXO-mediated transcription	0.010161	1.993
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.012540	1.902
R-HSA-9700206	Signaling by ALK in cancer	0.012540	1.902
R-HSA-9682385	FLT3 signaling in disease	0.013267	1.877
R-HSA-397014	Muscle contraction	0.014540	1.837
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.018958	1.722
R-HSA-69620	Cell Cycle Checkpoints	0.026159	1.582
R-HSA-1640170	Cell Cycle	0.027388	1.562
R-HSA-9856651	MITF-M-dependent gene expression	0.030725	1.513
R-HSA-9017802	Noncanonical activation of NOTCH3	0.031784	1.498
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.032805	1.484
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.066353	1.178
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.081324	1.090
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	0.103339	0.986
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	0.103339	0.986
R-HSA-72165	mRNA Splicing - Minor Pathway	0.196146	0.707
R-HSA-72187	mRNA 3'-end processing	0.215449	0.667
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.249658	0.603
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.249658	0.603
R-HSA-8854518	AURKA Activation by TPX2	0.258730	0.587
R-HSA-156711	Polo-like kinase mediated events	0.088721	1.052
R-HSA-2299718	Condensation of Prophase Chromosomes	0.196146	0.707
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.237392	0.625
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.189609	0.722
R-HSA-1614603	Cysteine formation from homocysteine	0.039573	1.403
R-HSA-9927354	Co-stimulation by ICOS	0.043445	1.362
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	0.066353	1.178
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.066353	1.178
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	0.110561	0.956
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.114151	0.943
R-HSA-445095	Interaction between L1 and Ankyrins	0.124834	0.904
R-HSA-73856	RNA Polymerase II Transcription Termination	0.243549	0.613
R-HSA-5693606	DNA Double Strand Break Response	0.261730	0.582
R-HSA-69231	Cyclin D associated events in G1	0.189609	0.722
R-HSA-69236	G1 Phase	0.189609	0.722
R-HSA-9620244	Long-term potentiation	0.117726	0.929
R-HSA-9639288	Amino acids regulate mTORC1	0.218621	0.660
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.264718	0.577
R-HSA-69202	Cyclin E associated events during G1/S transition	0.270658	0.568
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.051142	1.291
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.135390	0.868
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.169681	0.770
R-HSA-9711097	Cellular response to starvation	0.158875	0.799
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.202632	0.693
R-HSA-69275	G2/M Transition	0.050327	1.298
R-HSA-375165	NCAM signaling for neurite out-growth	0.246610	0.608
R-HSA-453274	Mitotic G2-G2/M phases	0.051526	1.288
R-HSA-9609523	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	0.096059	1.017
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.145821	0.836
R-HSA-4608870	Asymmetric localization of PCP proteins	0.192884	0.715
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.177434	0.751
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.095948	1.018
R-HSA-5693532	DNA Double-Strand Break Repair	0.151842	0.819
R-HSA-390696	Adrenoceptors	0.043445	1.362
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	0.103339	0.986
R-HSA-194138	Signaling by VEGF	0.109938	0.959
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.124834	0.904
R-HSA-9675126	Diseases of mitotic cell cycle	0.142358	0.847
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.149271	0.826
R-HSA-1614517	Sulfide oxidation to sulfate	0.085030	1.070
R-HSA-8953854	Metabolism of RNA	0.263253	0.580
R-HSA-69278	Cell Cycle, Mitotic	0.212434	0.673
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	0.106957	0.971
R-HSA-397795	G-protein beta:gamma signalling	0.145821	0.836
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.203650	0.691
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.192884	0.715
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.062573	1.204
R-HSA-5635838	Activation of SMO	0.077604	1.110
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.173036	0.762
R-HSA-389356	Co-stimulation by CD28	0.202632	0.693
R-HSA-2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	0.156129	0.807
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.246610	0.608
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.099710	1.001
R-HSA-2408522	Selenoamino acid metabolism	0.167395	0.776
R-HSA-72312	rRNA processing	0.270612	0.568
R-HSA-73894	DNA Repair	0.198267	0.703
R-HSA-2559583	Cellular Senescence	0.191935	0.717
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.145821	0.836
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.162932	0.788
R-HSA-375280	Amine ligand-binding receptors	0.189609	0.722
R-HSA-114604	GPVI-mediated activation cascade	0.159537	0.797
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	0.138881	0.857
R-HSA-5693537	Resolution of D-Loop Structures	0.149271	0.826
R-HSA-5689896	Ovarian tumor domain proteases	0.162932	0.788
R-HSA-8878159	Transcriptional regulation by RUNX3	0.070903	1.149
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.092229	1.035
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	0.202632	0.693
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.246610	0.608
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	0.145821	0.836
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.110561	0.956
R-HSA-1614635	Sulfur amino acid metabolism	0.056696	1.246
R-HSA-5693538	Homology Directed Repair	0.099710	1.001
R-HSA-9012852	Signaling by NOTCH3	0.224928	0.648
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.258730	0.587
R-HSA-1614558	Degradation of cysteine and homocysteine	0.192884	0.715
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	0.179705	0.745
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.261730	0.582
R-HSA-212436	Generic Transcription Pathway	0.180855	0.743
R-HSA-73857	RNA Polymerase II Transcription	0.149866	0.824
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.228062	0.642
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.246610	0.608
R-HSA-6804757	Regulation of TP53 Degradation	0.159537	0.797
R-HSA-9730414	MITF-M-regulated melanocyte development	0.068350	1.165
R-HSA-9018519	Estrogen-dependent gene expression	0.127112	0.896
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.228062	0.642
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.169681	0.770
R-HSA-8878166	Transcriptional regulation by RUNX2	0.100973	0.996
R-HSA-71291	Metabolism of amino acids and derivatives	0.044013	1.356
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.209539	0.679
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.170742	0.768
R-HSA-9679506	SARS-CoV Infections	0.203193	0.692
R-HSA-5632684	Hedgehog 'on' state	0.273611	0.563
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.276552	0.558
R-HSA-8939211	ESR-mediated signaling	0.278094	0.556
R-HSA-74160	Gene expression (Transcription)	0.279040	0.554
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.279480	0.554
R-HSA-69473	G2/M DNA damage checkpoint	0.282398	0.549
R-HSA-1222556	ROS and RNS production in phagocytes	0.282398	0.549
R-HSA-380287	Centrosome maturation	0.285303	0.545
R-HSA-5689603	UCH proteinases	0.288197	0.540
R-HSA-416482	G alpha (12/13) signalling events	0.293951	0.532
R-HSA-4086400	PCP/CE pathway	0.293951	0.532
R-HSA-5693607	Processing of DNA double-strand break ends	0.302495	0.519
R-HSA-5688426	Deubiquitination	0.304986	0.516
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.305321	0.515
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.305321	0.515
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.310938	0.507
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.310938	0.507
R-HSA-438064	Post NMDA receptor activation events	0.322039	0.492
R-HSA-9711123	Cellular response to chemical stress	0.324312	0.489
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.324786	0.488
R-HSA-156902	Peptide chain elongation	0.324786	0.488
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.330248	0.481
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	0.332963	0.478
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.335667	0.474
R-HSA-156842	Eukaryotic Translation Elongation	0.338360	0.471
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.340566	0.468
R-HSA-162582	Signal Transduction	0.342605	0.465
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.343714	0.464
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	0.346375	0.460
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.346375	0.460
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	0.349026	0.457
R-HSA-72764	Eukaryotic Translation Termination	0.349026	0.457
R-HSA-72689	Formation of a pool of free 40S subunits	0.349026	0.457
R-HSA-6807878	COPI-mediated anterograde transport	0.351665	0.454
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.354295	0.451
R-HSA-5673001	RAF/MAP kinase cascade	0.355244	0.449
R-HSA-1257604	PIP3 activates AKT signaling	0.363999	0.439
R-HSA-2408557	Selenocysteine synthesis	0.364707	0.438
R-HSA-5684996	MAPK1/MAPK3 signaling	0.365454	0.437
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.367284	0.435
R-HSA-1483255	PI Metabolism	0.367284	0.435
R-HSA-192823	Viral mRNA Translation	0.369851	0.432
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	0.372408	0.429
R-HSA-5696398	Nucleotide Excision Repair	0.377490	0.423
R-HSA-382551	Transport of small molecules	0.380091	0.420
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	0.382533	0.417
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.385039	0.414
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.385039	0.414
R-HSA-1236975	Antigen processing-Cross presentation	0.385039	0.414
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.394963	0.403
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.394963	0.403
R-HSA-72613	Eukaryotic Translation Initiation	0.409554	0.388
R-HSA-72737	Cap-dependent Translation Initiation	0.409554	0.388
R-HSA-373760	L1CAM interactions	0.409554	0.388
R-HSA-2262752	Cellular responses to stress	0.410204	0.387
R-HSA-68875	Mitotic Prophase	0.419088	0.378
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.426139	0.370
R-HSA-2132295	MHC class II antigen presentation	0.426139	0.370
R-HSA-9006925	Intracellular signaling by second messengers	0.430887	0.366
R-HSA-69206	G1/S Transition	0.433106	0.363
R-HSA-69481	G2/M Checkpoints	0.437704	0.359
R-HSA-5683057	MAPK family signaling cascades	0.437797	0.359
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.444533	0.352
R-HSA-9006931	Signaling by Nuclear Receptors	0.459610	0.338
R-HSA-3858494	Beta-catenin independent WNT signaling	0.462346	0.335
R-HSA-9948299	Ribosome-associated quality control	0.466710	0.331
R-HSA-5358351	Signaling by Hedgehog	0.466710	0.331
R-HSA-8856828	Clathrin-mediated endocytosis	0.479596	0.319
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.485923	0.313
R-HSA-68886	M Phase	0.486195	0.313
R-HSA-199977	ER to Golgi Anterograde Transport	0.488015	0.312
R-HSA-69242	S Phase	0.490099	0.310
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.496301	0.304
R-HSA-9824446	Viral Infection Pathways	0.497486	0.303
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.498351	0.302
R-HSA-9609507	Protein localization	0.500394	0.301
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.504454	0.297
R-HSA-8953897	Cellular responses to stimuli	0.511518	0.291
R-HSA-877300	Interferon gamma signaling	0.512477	0.290
R-HSA-9006936	Signaling by TGFB family members	0.514463	0.289
R-HSA-5633007	Regulation of TP53 Activity	0.514463	0.289
R-HSA-72306	tRNA processing	0.535788	0.271
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.545173	0.263
R-HSA-168255	Influenza Infection	0.552547	0.258
R-HSA-5617833	Cilium Assembly	0.572223	0.242
R-HSA-68877	Mitotic Prometaphase	0.577440	0.238
R-HSA-72163	mRNA Splicing - Major Pathway	0.579165	0.237
R-HSA-948021	Transport to the Golgi and subsequent modification	0.592717	0.227
R-HSA-376176	Signaling by ROBO receptors	0.594381	0.226
R-HSA-72172	mRNA Splicing	0.597688	0.224
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.610652	0.214
R-HSA-8951664	Neddylation	0.624746	0.204
R-HSA-8878171	Transcriptional regulation by RUNX1	0.632358	0.199
R-HSA-157118	Signaling by NOTCH	0.652871	0.185
R-HSA-422475	Axon guidance	0.670934	0.173
R-HSA-388841	Regulation of T cell activation by CD28 family	0.674937	0.171
R-HSA-416476	G alpha (q) signalling events	0.685446	0.164
R-HSA-76002	Platelet activation, signaling and aggregation	0.698113	0.156
R-HSA-9675108	Nervous system development	0.704719	0.152
R-HSA-1483257	Phospholipid metabolism	0.723101	0.141
R-HSA-195721	Signaling by WNT	0.726500	0.139
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.730807	0.136
R-HSA-449147	Signaling by Interleukins	0.740379	0.131
R-HSA-1852241	Organelle biogenesis and maintenance	0.750204	0.125
R-HSA-112315	Transmission across Chemical Synapses	0.753275	0.123
R-HSA-199991	Membrane Trafficking	0.757932	0.120
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.808249	0.092
R-HSA-913531	Interferon Signaling	0.808249	0.092
R-HSA-1280218	Adaptive Immune System	0.813305	0.090
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.816789	0.088
R-HSA-597592	Post-translational protein modification	0.821245	0.086
R-HSA-1280215	Cytokine Signaling in Immune system	0.827123	0.082
R-HSA-5663205	Infectious disease	0.833959	0.079
R-HSA-1643685	Disease	0.836729	0.077
R-HSA-446203	Asparagine N-linked glycosylation	0.836874	0.077
R-HSA-388396	GPCR downstream signalling	0.837144	0.077
R-HSA-72766	Translation	0.841547	0.075
R-HSA-109582	Hemostasis	0.842322	0.075
R-HSA-5653656	Vesicle-mediated transport	0.854157	0.068
R-HSA-6798695	Neutrophil degranulation	0.858954	0.066
R-HSA-112316	Neuronal System	0.865265	0.063
R-HSA-372790	Signaling by GPCR	0.875882	0.058
R-HSA-168256	Immune System	0.896370	0.048
R-HSA-1266738	Developmental Biology	0.911634	0.040
R-HSA-168249	Innate Immune System	0.917767	0.037
R-HSA-500792	GPCR ligand binding	0.918742	0.037
R-HSA-392499	Metabolism of proteins	0.940607	0.027
R-HSA-1430728	Metabolism	0.997082	0.001
R-HSA-556833	Metabolism of lipids	0.998331	0.001

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CDK18	0.733	0.699	1	0.841
CDK19	0.732	0.721	1	0.818
P38G	0.729	0.681	1	0.877
CDK8	0.728	0.719	1	0.786
P38B	0.728	0.733	1	0.800
CDK17	0.727	0.679	1	0.871
CDK16	0.725	0.661	1	0.859
P38D	0.724	0.674	1	0.860
HIPK2	0.722	0.610	1	0.828
JNK2	0.722	0.675	1	0.834
ERK1	0.720	0.695	1	0.812
CDK1	0.714	0.625	1	0.836
JNK3	0.714	0.656	1	0.808
MAK	0.714	0.604	-2	0.751
P38A	0.714	0.720	1	0.739
CDK3	0.713	0.561	1	0.869
CDK5	0.711	0.629	1	0.777
DYRK2	0.710	0.594	1	0.749
KIS	0.710	0.549	1	0.763
DYRK4	0.710	0.584	1	0.838
CDK7	0.707	0.641	1	0.798
JNK1	0.703	0.595	1	0.843
CDK13	0.702	0.600	1	0.815
CDK12	0.701	0.604	1	0.830
CDK14	0.701	0.624	1	0.807
DYRK1B	0.700	0.550	1	0.802
DYRK1A	0.698	0.533	1	0.701
HIPK1	0.696	0.520	1	0.731
CLK3	0.692	0.372	1	0.522
HIPK4	0.691	0.451	1	0.542
ERK2	0.690	0.619	1	0.768
CDK9	0.687	0.568	1	0.807
CDK10	0.685	0.543	1	0.824
ICK	0.685	0.472	-3	0.642
CDK6	0.680	0.558	1	0.816
MOK	0.680	0.484	1	0.628
HIPK3	0.680	0.498	1	0.689
CDK4	0.680	0.580	1	0.837
DYRK3	0.675	0.398	1	0.694
MTOR	0.675	0.355	1	0.335
CDKL5	0.675	0.293	-3	0.609
CDK2	0.674	0.437	1	0.723
ERK5	0.673	0.327	1	0.465
CLK2	0.673	0.273	-3	0.607
NLK	0.671	0.483	1	0.550
CDKL1	0.670	0.249	-3	0.616
SRPK1	0.668	0.217	-3	0.592
GRK7	0.664	0.115	1	0.226
PRP4	0.661	0.324	-3	0.596
MOS	0.660	0.044	1	0.259
CLK1	0.660	0.246	-3	0.592
FAM20C	0.659	0.155	2	0.668
CDC7	0.659	0.021	1	0.229
SRPK2	0.659	0.173	-3	0.530
CLK4	0.658	0.219	-3	0.612
COT	0.657	-0.019	2	0.633
BMPR1B	0.656	0.008	1	0.227
PRPK	0.652	0.013	-1	0.549
NDR2	0.652	0.045	-3	0.677
MPSK1	0.652	0.249	1	0.240
LATS1	0.651	0.066	-3	0.688
PIM3	0.650	-0.014	-3	0.669
ATR	0.650	0.024	1	0.216
TGFBR1	0.650	0.010	-2	0.487
TBK1	0.649	-0.033	1	0.123
ERK7	0.648	0.186	2	0.367
SRPK3	0.647	0.136	-3	0.560
GSK3A	0.647	0.167	4	0.320
BMPR2	0.646	-0.114	-2	0.497
PDHK4	0.646	-0.028	1	0.232
GRK1	0.644	-0.005	-2	0.444
SKMLCK	0.644	-0.035	-2	0.446
IKKA	0.643	-0.033	-2	0.370
GRK5	0.643	-0.080	-3	0.681
PIM1	0.643	0.003	-3	0.630
BMPR1A	0.642	-0.008	1	0.214
MARK4	0.641	0.011	4	0.616
PRKD1	0.641	-0.025	-3	0.646
LATS2	0.641	-0.018	-5	0.609
ALK4	0.641	-0.037	-2	0.498
MAPKAPK2	0.641	-0.005	-3	0.590
ALK2	0.641	-0.023	-2	0.483
CAMK2G	0.640	-0.053	2	0.590
CAMK1B	0.640	-0.060	-3	0.665
DNAPK	0.639	0.026	1	0.172
ACVR2B	0.639	-0.049	-2	0.489
IKKE	0.639	-0.112	1	0.122
TGFBR2	0.638	-0.093	-2	0.500
ACVR2A	0.638	-0.048	-2	0.489
PKCD	0.638	-0.015	2	0.568
CAMK2B	0.638	-0.012	2	0.583
RAF1	0.637	-0.146	1	0.176
RSK2	0.637	-0.027	-3	0.612
CAMLCK	0.637	-0.050	-2	0.419
PKN3	0.637	-0.056	-3	0.640
ATM	0.637	-0.034	1	0.184
PDHK1	0.636	-0.125	1	0.198
NIK	0.636	-0.095	-3	0.675
NUAK2	0.636	-0.033	-3	0.661
MLK2	0.635	-0.042	2	0.587
MLK3	0.635	-0.008	2	0.547
GRK6	0.635	-0.069	1	0.203
CAMK2D	0.635	-0.057	-3	0.626
GCN2	0.634	-0.155	2	0.545
IKKB	0.634	-0.156	-2	0.336
P90RSK	0.634	-0.028	-3	0.606
NDR1	0.633	-0.054	-3	0.665
CK2A2	0.633	0.050	1	0.209
TLK2	0.633	-0.072	1	0.147
CAMK2A	0.633	-0.018	2	0.568
MLK1	0.633	-0.103	2	0.597
DSTYK	0.633	-0.163	2	0.657
BCKDK	0.632	-0.071	-1	0.568
MST4	0.632	-0.031	2	0.656
DAPK2	0.632	-0.080	-3	0.662
MASTL	0.632	-0.114	-2	0.437
GRK4	0.631	-0.111	-2	0.470
PKCA	0.631	0.010	2	0.525
CHAK2	0.631	-0.068	-1	0.455
GRK2	0.631	-0.053	-2	0.399
RSK4	0.630	-0.009	-3	0.591
VRK2	0.630	0.018	1	0.271
MAPKAPK3	0.630	-0.066	-3	0.611
PLK3	0.629	-0.052	2	0.537
QSK	0.629	-0.001	4	0.599
WNK1	0.629	-0.086	-2	0.464
MLK4	0.628	-0.052	2	0.525
NIM1	0.628	0.011	3	0.699
TSSK1	0.628	-0.061	-3	0.687
CHK1	0.628	-0.058	-3	0.677
AMPKA1	0.628	-0.073	-3	0.673
RSK3	0.628	-0.049	-3	0.615
NEK6	0.628	-0.130	-2	0.493
RIPK3	0.627	-0.108	3	0.675
DLK	0.627	-0.164	1	0.189
PKACB	0.627	-0.026	-2	0.281
MEK1	0.627	-0.099	2	0.583
SGK3	0.626	-0.018	-3	0.627
PKCG	0.626	-0.018	2	0.530
PKCB	0.626	-0.031	2	0.538
PRKD2	0.626	-0.050	-3	0.606
YSK4	0.626	-0.143	1	0.145
PLK1	0.626	-0.118	-2	0.457
MARK3	0.626	-0.006	4	0.551
PAK1	0.625	-0.058	-2	0.395
AMPKA2	0.624	-0.056	-3	0.648
PKN2	0.624	-0.097	-3	0.654
ULK2	0.624	-0.209	2	0.550
P70S6KB	0.623	-0.067	-3	0.618
PKACG	0.623	-0.071	-2	0.333
TAO3	0.623	0.001	1	0.192
MARK2	0.623	-0.017	4	0.521
PKR	0.623	-0.116	1	0.189
TTBK2	0.622	-0.143	2	0.482
PRKX	0.622	-0.012	-3	0.580
HUNK	0.622	-0.185	2	0.565
AURC	0.622	-0.059	-2	0.284
PASK	0.622	-0.026	-3	0.671
SIK	0.621	-0.023	-3	0.594
CK2A1	0.621	0.026	1	0.202
GRK3	0.621	-0.055	-2	0.384
NEK7	0.621	-0.229	-3	0.584
MSK2	0.620	-0.063	-3	0.585
PLK4	0.620	-0.066	2	0.430
IRE2	0.620	-0.080	2	0.560
GSK3B	0.620	0.024	4	0.307
TSSK2	0.620	-0.127	-5	0.669
NEK9	0.620	-0.204	2	0.592
IRE1	0.619	-0.106	1	0.163
DCAMKL1	0.619	-0.053	-3	0.642
CK1E	0.619	0.014	-3	0.489
SMG1	0.619	-0.086	1	0.190
NUAK1	0.618	-0.068	-3	0.618
AKT2	0.618	-0.027	-3	0.548
PLK2	0.618	0.003	-3	0.695
MEKK2	0.618	-0.101	2	0.566
PIM2	0.618	-0.035	-3	0.587
SBK	0.617	0.067	-3	0.456
MSK1	0.617	-0.060	-3	0.595
WNK3	0.617	-0.186	1	0.154
ANKRD3	0.617	-0.257	1	0.185
MARK1	0.617	-0.038	4	0.570
RIPK1	0.616	-0.185	1	0.160
PKCZ	0.616	-0.074	2	0.544
TLK1	0.616	-0.142	-2	0.492
PERK	0.616	-0.171	-2	0.490
QIK	0.615	-0.082	-3	0.629
PKCH	0.615	-0.080	2	0.516
PINK1	0.615	0.010	1	0.380
PAK3	0.615	-0.107	-2	0.364
BRSK1	0.614	-0.067	-3	0.626
MNK2	0.614	-0.087	-2	0.353
MST3	0.614	-0.065	2	0.614
MEK5	0.614	-0.162	2	0.578
PRKD3	0.613	-0.072	-3	0.588
MST2	0.613	-0.080	1	0.163
ULK1	0.613	-0.207	-3	0.559
BRAF	0.613	-0.131	-4	0.798
GCK	0.613	-0.042	1	0.185
MEKK1	0.613	-0.139	1	0.162
MNK1	0.613	-0.080	-2	0.355
PAK2	0.612	-0.104	-2	0.376
CAMK4	0.612	-0.159	-3	0.639
AURA	0.612	-0.079	-2	0.269
ZAK	0.612	-0.153	1	0.150
SGK1	0.612	0.002	-3	0.503
PHKG1	0.611	-0.115	-3	0.644
WNK4	0.611	-0.098	-2	0.482
MEKK3	0.611	-0.165	1	0.174
MELK	0.611	-0.126	-3	0.626
CK1D	0.611	0.001	-3	0.437
PAK6	0.611	-0.064	-2	0.290
PKG2	0.610	-0.087	-2	0.283
PKACA	0.610	-0.047	-2	0.247
HRI	0.610	-0.197	-2	0.499
MAP3K15	0.609	-0.007	1	0.154
PDK1	0.609	-0.062	1	0.194
GAK	0.609	-0.073	1	0.250
NEK5	0.609	-0.176	1	0.157
BRSK2	0.609	-0.094	-3	0.630
AURB	0.609	-0.092	-2	0.277
DRAK1	0.608	-0.145	1	0.196
TNIK	0.608	-0.043	3	0.690
TAO2	0.607	-0.074	2	0.616
DCAMKL2	0.607	-0.082	-3	0.638
NEK11	0.607	-0.113	1	0.185
AKT1	0.607	-0.049	-3	0.564
MYLK4	0.607	-0.105	-2	0.331
NEK2	0.606	-0.193	2	0.570
KHS1	0.606	-0.024	1	0.157
PBK	0.606	-0.028	1	0.214
HGK	0.605	-0.072	3	0.689
MEKK6	0.605	-0.058	1	0.160
PKCT	0.604	-0.086	2	0.521
CAMK1D	0.603	-0.068	-3	0.550
CHAK1	0.603	-0.194	2	0.518
ROCK2	0.603	-0.046	-3	0.640
MINK	0.603	-0.095	1	0.142
SMMLCK	0.602	-0.101	-3	0.621
VRK1	0.602	-0.114	2	0.609
LKB1	0.602	-0.104	-3	0.590
PKCE	0.601	-0.049	2	0.528
AKT3	0.601	-0.033	-3	0.512
EEF2K	0.601	-0.072	3	0.655
HPK1	0.601	-0.081	1	0.182
KHS2	0.600	-0.034	1	0.177
DAPK3	0.600	-0.087	-3	0.628
LRRK2	0.600	-0.078	2	0.596
BUB1	0.600	-0.044	-5	0.623
CAMK1G	0.599	-0.107	-3	0.566
CK1A2	0.599	-0.023	-3	0.443
MST1	0.599	-0.122	1	0.144
HASPIN	0.598	-0.021	-1	0.378
PAK5	0.598	-0.085	-2	0.282
CK1G1	0.597	-0.038	-3	0.490
IRAK4	0.597	-0.178	1	0.137
AAK1	0.597	0.001	1	0.238
MAPKAPK5	0.596	-0.135	-3	0.533
PKCI	0.595	-0.096	2	0.529
CAMKK2	0.595	-0.194	-2	0.321
TTK	0.595	-0.089	-2	0.502
SLK	0.595	-0.122	-2	0.366
ALPHAK3	0.595	-0.025	-1	0.427
SSTK	0.595	-0.120	4	0.578
BIKE	0.595	-0.040	1	0.237
P70S6K	0.595	-0.090	-3	0.546
NEK8	0.594	-0.238	2	0.585
NEK4	0.594	-0.179	1	0.134
LOK	0.594	-0.137	-2	0.357
DAPK1	0.594	-0.089	-3	0.610
TAK1	0.594	-0.215	1	0.154
PAK4	0.593	-0.079	-2	0.293
YSK1	0.593	-0.096	2	0.583
CAMKK1	0.593	-0.245	-2	0.314
CAMK1A	0.592	-0.066	-3	0.526
MRCKB	0.592	-0.069	-3	0.580
NEK1	0.592	-0.168	1	0.136
MRCKA	0.591	-0.077	-3	0.597
OSR1	0.591	-0.109	2	0.545
TTBK1	0.591	-0.165	2	0.425
DMPK1	0.590	-0.044	-3	0.605
CHK2	0.590	-0.079	-3	0.513
PKN1	0.589	-0.087	-3	0.560
SNRK	0.588	-0.208	2	0.460
MEK2	0.588	-0.184	2	0.560
ASK1	0.588	-0.072	1	0.154
PHKG2	0.588	-0.136	-3	0.622
CRIK	0.586	-0.041	-3	0.564
MYO3A	0.585	-0.073	1	0.161
ROCK1	0.584	-0.073	-3	0.601
MYO3B	0.583	-0.087	2	0.606
IRAK1	0.581	-0.262	-1	0.431
NEK3	0.581	-0.152	1	0.141
TAO1	0.580	-0.100	1	0.138
PKG1	0.578	-0.100	-2	0.218
YANK3	0.577	-0.056	2	0.263
PDHK3_TYR	0.576	0.190	4	0.703
RIPK2	0.573	-0.247	1	0.126
CK1A	0.572	-0.032	-3	0.381
STK33	0.570	-0.185	2	0.391
STLK3	0.570	-0.182	1	0.128
PKMYT1_TYR	0.569	0.161	3	0.752
MAP2K6_TYR	0.568	0.079	-1	0.542
PDHK4_TYR	0.568	0.084	2	0.623
MAP2K4_TYR	0.567	0.087	-1	0.566
PDHK1_TYR	0.566	0.067	-1	0.522
LIMK2_TYR	0.565	0.099	-3	0.668
TESK1_TYR	0.563	0.007	3	0.774
MAP2K7_TYR	0.561	-0.008	2	0.617
BMPR2_TYR	0.560	-0.005	-1	0.515
TXK	0.559	-0.012	1	0.199
YES1	0.554	-0.038	-1	0.520
CSF1R	0.553	-0.028	3	0.688
PINK1_TYR	0.552	-0.140	1	0.231
RET	0.550	-0.127	1	0.173
LIMK1_TYR	0.550	-0.030	2	0.621
YANK2	0.549	-0.071	2	0.272
EPHB4	0.549	-0.083	-1	0.478
JAK2	0.549	-0.089	1	0.172
CK1G3	0.548	-0.062	-3	0.346
ABL2	0.548	-0.077	-1	0.471
FYN	0.547	-0.036	-1	0.468
FGFR2	0.547	-0.050	3	0.716
FGR	0.547	-0.140	1	0.178
FER	0.547	-0.130	1	0.194
INSRR	0.546	-0.083	3	0.662
ROS1	0.546	-0.098	3	0.654
MST1R	0.546	-0.110	3	0.702
SRMS	0.546	-0.103	1	0.178
EPHA6	0.545	-0.112	-1	0.474
DDR1	0.545	-0.099	4	0.590
TYK2	0.544	-0.177	1	0.156
ABL1	0.544	-0.086	-1	0.479
TYRO3	0.544	-0.145	3	0.675
LCK	0.543	-0.087	-1	0.477
EPHA4	0.543	-0.065	2	0.549
JAK1	0.542	-0.064	1	0.139
FGFR1	0.542	-0.062	3	0.678
MERTK	0.542	-0.102	3	0.702
BLK	0.542	-0.069	-1	0.475
ITK	0.542	-0.106	-1	0.455
NEK10_TYR	0.542	-0.094	1	0.139
KIT	0.541	-0.103	3	0.688
EGFR	0.539	-0.062	1	0.131
HCK	0.539	-0.137	-1	0.479
EPHB2	0.538	-0.116	-1	0.462
TNNI3K_TYR	0.538	-0.071	1	0.178
JAK3	0.538	-0.148	1	0.169
TNK1	0.538	-0.070	3	0.676
FGFR3	0.537	-0.073	3	0.695
TNK2	0.537	-0.083	3	0.633
TEK	0.537	-0.064	3	0.623
AXL	0.537	-0.132	3	0.694
EPHB1	0.537	-0.152	1	0.171
EPHB3	0.537	-0.136	-1	0.472
DDR2	0.536	-0.019	3	0.636
KDR	0.536	-0.111	3	0.669
NTRK3	0.536	-0.100	-1	0.472
SRC	0.536	-0.068	-1	0.486
PDGFRB	0.535	-0.175	3	0.684
PTK6	0.535	-0.150	-1	0.445
BMX	0.535	-0.102	-1	0.387
NTRK1	0.535	-0.144	-1	0.495
MET	0.534	-0.103	3	0.682
CK1G2	0.534	-0.073	-3	0.418
FLT3	0.534	-0.159	3	0.661
PTK2B	0.533	-0.088	-1	0.480
FGFR4	0.533	-0.066	-1	0.439
CSK	0.532	-0.054	2	0.548
PTK2	0.531	-0.055	-1	0.402
EPHA7	0.531	-0.103	2	0.543
INSR	0.531	-0.114	3	0.635
TEC	0.530	-0.145	-1	0.429
FLT1	0.530	-0.145	-1	0.444
SYK	0.529	-0.083	-1	0.397
ALK	0.529	-0.152	3	0.612
PDGFRA	0.529	-0.171	3	0.671
EPHA8	0.528	-0.094	-1	0.436
EPHA5	0.528	-0.111	2	0.539
LTK	0.528	-0.153	3	0.649
FLT4	0.528	-0.142	3	0.678
ERBB2	0.527	-0.155	1	0.160
LYN	0.527	-0.119	3	0.618
NTRK2	0.527	-0.177	3	0.667
BTK	0.527	-0.195	-1	0.445
MATK	0.527	-0.095	-1	0.419
WEE1_TYR	0.527	-0.128	-1	0.446
EPHA3	0.526	-0.137	2	0.525
FRK	0.526	-0.140	-1	0.468
ERBB4	0.525	-0.072	1	0.154
EPHA1	0.523	-0.152	3	0.660
IGF1R	0.522	-0.104	3	0.591
EPHA2	0.516	-0.118	-1	0.396
ZAP70	0.516	-0.074	-1	0.358
MUSK	0.509	-0.166	1	0.120
FES	0.509	-0.115	-1	0.402