Motif 274 (n=80)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKD9 | CCDC85C | S258 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A6NKT7 | RGPD3 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14715 | RGPD8 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15061 | SYNM | S1304 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15371 | EIF3D | S34 | ochoa | Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66) | mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O60271 | SPAG9 | S1188 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| P04075 | ALDOA | S100 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P04155 | TFF1 | S49 | ochoa | Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2) | Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}. |
| P06576 | ATP5F1B | S316 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P08588 | ADRB1 | S423 | ochoa|psp | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:31473062}. |
| P0CG47 | UBB | S57 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | S57 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P0DJD0 | RGPD1 | S1465 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1473 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10768 | ESD | S214 | ochoa | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) | Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}. |
| P11836 | MS4A1 | S25 | ochoa | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
| P17661 | DES | S82 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P21554 | CNR1 | S316 | ochoa | Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) | G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712). {ECO:0000250|UniProtKB:O02777, ECO:0000250|UniProtKB:P47746, ECO:0000269|PubMed:15620723, ECO:0000269|PubMed:1718258, ECO:0000269|PubMed:17895407, ECO:0000269|PubMed:21895628, ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}.; FUNCTION: [Isoform 1]: Binds both 2-arachidonoylglycerol (2-AG) and anandamide. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 2]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 3]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}. |
| P31629 | HIVEP2 | S563 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P39019 | RPS19 | S59 | psp | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P42566 | EPS15 | S330 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P45974 | USP5 | S715 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P49327 | FASN | S286 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S2456 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51812 | RPS6KA3 | S375 | ochoa | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| P55072 | VCP | S352 | ochoa|psp | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56945 | BCAR1 | S292 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P62979 | RPS27A | S57 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | S57 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P68363 | TUBA1B | S237 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S237 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P79483 | HLA-DRB3 | S117 | ochoa | HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3) | A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:16148104, PubMed:19531622, PubMed:19830726, PubMed:20368442, PubMed:22929521, PubMed:23569328, PubMed:2463305, PubMed:2788702, PubMed:30282837, PubMed:31020640, PubMed:31308093, PubMed:31333679). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity). {ECO:0000250|UniProtKB:P01911, ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2463305, PubMed:2788702). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:31020640}.; FUNCTION: ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:23569328, PubMed:31308093). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M.tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104). {ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:32341563}. |
| Q00613 | HSF1 | S344 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q03252 | LMNB2 | S559 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q13009 | TIAM1 | S329 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q14934 | NFATC4 | S279 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15398 | DLGAP5 | S332 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15398 | DLGAP5 | S812 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15418 | RPS6KA1 | S369 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q30154 | HLA-DRB5 | S117 | ochoa | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. |
| Q32P44 | EML3 | S204 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q5SYE7 | NHSL1 | S1367 | ochoa | NHS-like protein 1 | None |
| Q7L9B9 | EEPD1 | S247 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7RTP6 | MICAL3 | S870 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z3J3 | RGPD4 | S1481 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6Z7 | HUWE1 | S2600 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q8TBZ3 | WDR20 | S364 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TCG2 | PI4K2B | S45 | ochoa | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. |
| Q8WWI1 | LMO7 | S930 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WX93 | PALLD | S1179 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WYP5 | AHCTF1 | S1108 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q96C34 | RUNDC1 | S497 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96JY6 | PDLIM2 | S178 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96PE1 | ADGRA2 | S987 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
| Q96RG2 | PASK | S956 | ochoa|psp | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RT1 | ERBIN | S1179 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99459 | CDC5L | S358 | ochoa|psp | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q99666 | RGPD5 | S1480 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99959 | PKP2 | S251 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQE3 | TUBA1C | S237 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BX66 | SORBS1 | S479 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9H853 | TUBA4B | S176 | ochoa | Tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed ofalpha- and beta-tubulin heterodimers. {ECO:0000250|UniProtKB:P68363}. |
| Q9NR48 | ASH1L | S1754 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NXH8 | TOR4A | S87 | ochoa | Torsin-4A (Torsin family 4 member A) | None |
| Q9NY65 | TUBA8 | S237 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9NYF3 | FAM53C | S82 | ochoa | Protein FAM53C | None |
| Q9P1Y6 | PHRF1 | S107 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P242 | NYAP2 | S475 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9UHR4 | BAIAP2L1 | S395 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UK32 | RPS6KA6 | S378 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UQ35 | SRRM2 | S2198 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y282 | ERGIC3 | S116 | ochoa | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) | Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}. |
| P14314 | PRKCSH | S478 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| Q8NBJ7 | SUMF2 | S281 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| O15111 | CHUK | S369 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O15013 | ARHGEF10 | S1330 | Sugiyama | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| P49588 | AARS1 | S237 | Sugiyama | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| Q15349 | RPS6KA2 | S366 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9NP81 | SARS2 | S184 | Sugiyama | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO:0000250|UniProtKB:Q9N0F3}. |
| Q04637 | EIF4G1 | S1041 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9646399 | Aggrephagy | 4.440892e-15 | 14.353 |
| R-HSA-9663891 | Selective autophagy | 1.018541e-11 | 10.992 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.799549e-11 | 10.745 |
| R-HSA-437239 | Recycling pathway of L1 | 3.482559e-11 | 10.458 |
| R-HSA-913531 | Interferon Signaling | 1.008251e-10 | 9.996 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.851065e-10 | 9.545 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.262434e-10 | 9.279 |
| R-HSA-1632852 | Macroautophagy | 1.656572e-09 | 8.781 |
| R-HSA-450294 | MAP kinase activation | 6.446083e-09 | 8.191 |
| R-HSA-9612973 | Autophagy | 4.452982e-09 | 8.351 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.349195e-09 | 8.362 |
| R-HSA-68882 | Mitotic Anaphase | 9.327739e-09 | 8.030 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.769164e-09 | 8.010 |
| R-HSA-5689877 | Josephin domain DUBs | 1.423350e-08 | 7.847 |
| R-HSA-422475 | Axon guidance | 1.531886e-08 | 7.815 |
| R-HSA-448424 | Interleukin-17 signaling | 1.650332e-08 | 7.782 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.746707e-08 | 7.758 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 3.967069e-08 | 7.402 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 3.967069e-08 | 7.402 |
| R-HSA-9675108 | Nervous system development | 3.820860e-08 | 7.418 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 7.086249e-08 | 7.150 |
| R-HSA-373760 | L1CAM interactions | 5.708828e-08 | 7.243 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 8.855341e-08 | 7.053 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 9.245154e-08 | 7.034 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 9.245154e-08 | 7.034 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.189566e-07 | 6.925 |
| R-HSA-9694493 | Maturation of protein E | 1.504248e-07 | 6.823 |
| R-HSA-9683683 | Maturation of protein E | 1.504248e-07 | 6.823 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.899053e-07 | 6.721 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.085956e-07 | 6.681 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.085956e-07 | 6.681 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.085956e-07 | 6.681 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.361325e-07 | 6.627 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.908478e-07 | 6.536 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.908478e-07 | 6.536 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.545359e-07 | 6.450 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.551425e-07 | 6.450 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.551425e-07 | 6.450 |
| R-HSA-8948747 | Regulation of PTEN localization | 3.641268e-07 | 6.439 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.282808e-07 | 6.368 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.556137e-07 | 6.341 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.556137e-07 | 6.341 |
| R-HSA-444257 | RSK activation | 5.308481e-07 | 6.275 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 5.308481e-07 | 6.275 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 5.308481e-07 | 6.275 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 5.308481e-07 | 6.275 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.844262e-07 | 6.315 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.844262e-07 | 6.315 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 5.172591e-07 | 6.286 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.967675e-07 | 6.304 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 5.308481e-07 | 6.275 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 5.308481e-07 | 6.275 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.804096e-07 | 6.236 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 7.486378e-07 | 6.126 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.922133e-07 | 6.160 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.484310e-07 | 6.071 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 8.645232e-07 | 6.063 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.026757e-06 | 5.989 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 9.494500e-07 | 6.023 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.194958e-07 | 6.036 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.194958e-07 | 6.036 |
| R-HSA-9664873 | Pexophagy | 1.026757e-06 | 5.989 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.026780e-06 | 5.989 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.084311e-06 | 5.965 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.084311e-06 | 5.965 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.374113e-06 | 5.862 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.374113e-06 | 5.862 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.375162e-06 | 5.862 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.375162e-06 | 5.862 |
| R-HSA-202424 | Downstream TCR signaling | 1.587707e-06 | 5.799 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.588334e-06 | 5.799 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.685173e-06 | 5.773 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.804491e-06 | 5.744 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.095314e-06 | 5.679 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.804491e-06 | 5.744 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.804491e-06 | 5.744 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.163868e-06 | 5.665 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.326044e-06 | 5.633 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.326044e-06 | 5.633 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.326044e-06 | 5.633 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.326044e-06 | 5.633 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 2.326044e-06 | 5.633 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.392434e-06 | 5.621 |
| R-HSA-182971 | EGFR downregulation | 2.392434e-06 | 5.621 |
| R-HSA-69275 | G2/M Transition | 2.450224e-06 | 5.611 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.649822e-06 | 5.577 |
| R-HSA-68886 | M Phase | 2.699676e-06 | 5.569 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.832510e-06 | 5.548 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.951767e-06 | 5.530 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 3.694239e-06 | 5.432 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.694239e-06 | 5.432 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 3.694239e-06 | 5.432 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.350661e-06 | 5.475 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.085635e-06 | 5.511 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.927640e-06 | 5.406 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.927640e-06 | 5.406 |
| R-HSA-190861 | Gap junction assembly | 3.927640e-06 | 5.406 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 4.566656e-06 | 5.340 |
| R-HSA-110312 | Translesion synthesis by REV1 | 4.566656e-06 | 5.340 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 4.566656e-06 | 5.340 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 4.566656e-06 | 5.340 |
| R-HSA-193639 | p75NTR signals via NF-kB | 4.566656e-06 | 5.340 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.664194e-06 | 5.331 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.940217e-06 | 5.306 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.517763e-06 | 5.258 |
| R-HSA-5656121 | Translesion synthesis by POLI | 5.582811e-06 | 5.253 |
| R-HSA-9708530 | Regulation of BACH1 activity | 5.582811e-06 | 5.253 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.582811e-06 | 5.253 |
| R-HSA-202403 | TCR signaling | 6.178669e-06 | 5.209 |
| R-HSA-5655862 | Translesion synthesis by POLK | 6.757087e-06 | 5.170 |
| R-HSA-8852135 | Protein ubiquitination | 8.060349e-06 | 5.094 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 8.104433e-06 | 5.091 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 6.757087e-06 | 5.170 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 6.757087e-06 | 5.170 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.025308e-06 | 5.153 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 6.757087e-06 | 5.170 |
| R-HSA-3229121 | Glycogen storage diseases | 8.104433e-06 | 5.091 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.601719e-06 | 5.180 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 8.377048e-06 | 5.077 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 8.377048e-06 | 5.077 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 8.377048e-06 | 5.077 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 9.246171e-06 | 5.034 |
| R-HSA-9683701 | Translation of Structural Proteins | 9.246171e-06 | 5.034 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.640357e-06 | 5.016 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 9.640357e-06 | 5.016 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.119505e-05 | 4.951 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.119716e-05 | 4.951 |
| R-HSA-9833482 | PKR-mediated signaling | 1.119716e-05 | 4.951 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.138091e-05 | 4.944 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.138091e-05 | 4.944 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.604642e-05 | 4.795 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.300530e-05 | 4.886 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.554269e-05 | 4.808 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.345083e-05 | 4.871 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 1.604642e-05 | 4.795 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.345083e-05 | 4.871 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.470402e-05 | 4.833 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.554269e-05 | 4.808 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 1.554269e-05 | 4.808 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.554269e-05 | 4.808 |
| R-HSA-190828 | Gap junction trafficking | 1.228257e-05 | 4.911 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 1.554269e-05 | 4.808 |
| R-HSA-2262752 | Cellular responses to stress | 1.571047e-05 | 4.804 |
| R-HSA-3322077 | Glycogen synthesis | 1.334265e-05 | 4.875 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.430012e-05 | 4.845 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.554269e-05 | 4.808 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.554269e-05 | 4.808 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.799860e-05 | 4.745 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.799860e-05 | 4.745 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.799860e-05 | 4.745 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.799860e-05 | 4.745 |
| R-HSA-73893 | DNA Damage Bypass | 1.901668e-05 | 4.721 |
| R-HSA-9766229 | Degradation of CDH1 | 1.901668e-05 | 4.721 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.901668e-05 | 4.721 |
| R-HSA-199920 | CREB phosphorylation | 1.977647e-05 | 4.704 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.055485e-05 | 4.687 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.072845e-05 | 4.683 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.072845e-05 | 4.683 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.239838e-05 | 4.650 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.239838e-05 | 4.650 |
| R-HSA-162582 | Signal Transduction | 2.334797e-05 | 4.632 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.425556e-05 | 4.615 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.425556e-05 | 4.615 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.507655e-05 | 4.601 |
| R-HSA-68877 | Mitotic Prometaphase | 2.680861e-05 | 4.572 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.708461e-05 | 4.567 |
| R-HSA-72649 | Translation initiation complex formation | 2.832765e-05 | 4.548 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.846129e-05 | 4.546 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.995547e-05 | 4.524 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.055299e-05 | 4.515 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.912145e-05 | 4.309 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.912145e-05 | 4.309 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.291166e-05 | 4.483 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.476493e-05 | 4.459 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.805118e-05 | 4.420 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.912145e-05 | 4.309 |
| R-HSA-72766 | Translation | 4.418284e-05 | 4.355 |
| R-HSA-75893 | TNF signaling | 3.291166e-05 | 4.483 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.379172e-05 | 4.359 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.540918e-05 | 4.451 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.476493e-05 | 4.459 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.915159e-05 | 4.407 |
| R-HSA-177929 | Signaling by EGFR | 3.291166e-05 | 4.483 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.393007e-05 | 4.357 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.912145e-05 | 4.309 |
| R-HSA-983189 | Kinesins | 4.379172e-05 | 4.359 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.872875e-05 | 4.412 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.476493e-05 | 4.459 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.393007e-05 | 4.357 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.838403e-05 | 4.416 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.293625e-05 | 4.367 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.912145e-05 | 4.309 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.476493e-05 | 4.459 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.079282e-05 | 4.294 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.363385e-05 | 4.271 |
| R-HSA-8848021 | Signaling by PTK6 | 5.363385e-05 | 4.271 |
| R-HSA-73887 | Death Receptor Signaling | 5.463323e-05 | 4.263 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.695265e-05 | 4.244 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.726773e-05 | 4.242 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 5.964474e-05 | 4.224 |
| R-HSA-9700206 | Signaling by ALK in cancer | 5.964474e-05 | 4.224 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 6.082922e-05 | 4.216 |
| R-HSA-162588 | Budding and maturation of HIV virion | 6.082922e-05 | 4.216 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 6.082922e-05 | 4.216 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 6.082922e-05 | 4.216 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.243764e-05 | 4.205 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.243764e-05 | 4.205 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6.738966e-05 | 4.171 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.374252e-05 | 4.132 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.445110e-05 | 4.128 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 7.445110e-05 | 4.128 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 7.445110e-05 | 4.128 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.990048e-05 | 4.097 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.203641e-05 | 4.086 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 8.203641e-05 | 4.086 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 8.323869e-05 | 4.080 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 8.323869e-05 | 4.080 |
| R-HSA-5696400 | Dual Incision in GG-NER | 9.016883e-05 | 4.045 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 9.016883e-05 | 4.045 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 9.016883e-05 | 4.045 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 9.016883e-05 | 4.045 |
| R-HSA-1980145 | Signaling by NOTCH2 | 9.016883e-05 | 4.045 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 9.016883e-05 | 4.045 |
| R-HSA-5205647 | Mitophagy | 9.016883e-05 | 4.045 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 9.364940e-05 | 4.028 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.654075e-05 | 4.015 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.654075e-05 | 4.015 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 9.887185e-05 | 4.005 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 9.887185e-05 | 4.005 |
| R-HSA-169911 | Regulation of Apoptosis | 9.887185e-05 | 4.005 |
| R-HSA-2559585 | Oncogene Induced Senescence | 9.887185e-05 | 4.005 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 9.921603e-05 | 4.003 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.070101e-04 | 3.971 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.081693e-04 | 3.966 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.081693e-04 | 3.966 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.081693e-04 | 3.966 |
| R-HSA-4641258 | Degradation of DVL | 1.180854e-04 | 3.928 |
| R-HSA-4641257 | Degradation of AXIN | 1.180854e-04 | 3.928 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.180854e-04 | 3.928 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.180854e-04 | 3.928 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.180854e-04 | 3.928 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.240680e-04 | 3.906 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.286443e-04 | 3.891 |
| R-HSA-5619084 | ABC transporter disorders | 1.309664e-04 | 3.883 |
| R-HSA-2559583 | Cellular Senescence | 1.342996e-04 | 3.872 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.347091e-04 | 3.871 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.398709e-04 | 3.854 |
| R-HSA-69541 | Stabilization of p53 | 1.398709e-04 | 3.854 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.398709e-04 | 3.854 |
| R-HSA-9648002 | RAS processing | 1.398709e-04 | 3.854 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.398709e-04 | 3.854 |
| R-HSA-6806834 | Signaling by MET | 1.456419e-04 | 3.837 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.517901e-04 | 3.819 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.517901e-04 | 3.819 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.517901e-04 | 3.819 |
| R-HSA-8982491 | Glycogen metabolism | 1.517901e-04 | 3.819 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.644269e-04 | 3.784 |
| R-HSA-9607240 | FLT3 Signaling | 1.644269e-04 | 3.784 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.699767e-04 | 3.770 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.778069e-04 | 3.750 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.778069e-04 | 3.750 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.778069e-04 | 3.750 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.778069e-04 | 3.750 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.778069e-04 | 3.750 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.787413e-04 | 3.748 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.919556e-04 | 3.717 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.973025e-04 | 3.705 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.068990e-04 | 3.684 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.068990e-04 | 3.684 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.068990e-04 | 3.684 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.172989e-04 | 3.663 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.567584e-04 | 3.590 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.278580e-04 | 3.642 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.740509e-04 | 3.562 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.414137e-04 | 3.467 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.414137e-04 | 3.467 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.751428e-04 | 3.560 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.815095e-04 | 3.418 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.058626e-04 | 3.392 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.058626e-04 | 3.392 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.815095e-04 | 3.418 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.313066e-04 | 3.365 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.058626e-04 | 3.392 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.567584e-04 | 3.590 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.392740e-04 | 3.621 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.380059e-04 | 3.359 |
| R-HSA-391251 | Protein folding | 2.866357e-04 | 3.543 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.567584e-04 | 3.590 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.582196e-04 | 3.446 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.226630e-04 | 3.652 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.562677e-04 | 3.448 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 3.529844e-04 | 3.452 |
| R-HSA-1280218 | Adaptive Immune System | 2.653236e-04 | 3.576 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.359653e-04 | 3.474 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.392740e-04 | 3.621 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.392740e-04 | 3.621 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.567584e-04 | 3.590 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.147192e-04 | 3.502 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.147192e-04 | 3.502 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.388033e-04 | 3.622 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.562677e-04 | 3.448 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.400148e-04 | 3.620 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.562677e-04 | 3.448 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.270336e-04 | 3.485 |
| R-HSA-382556 | ABC-family proteins mediated transport | 4.206278e-04 | 3.376 |
| R-HSA-198753 | ERK/MAPK targets | 4.451866e-04 | 3.351 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.392740e-04 | 3.621 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.815095e-04 | 3.418 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.937022e-04 | 3.532 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.604691e-04 | 3.584 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.392740e-04 | 3.621 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.226630e-04 | 3.652 |
| R-HSA-69236 | G1 Phase | 2.226630e-04 | 3.652 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.147192e-04 | 3.502 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.866357e-04 | 3.543 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.578692e-04 | 3.339 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.855783e-04 | 3.314 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.855783e-04 | 3.314 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.855783e-04 | 3.314 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.855783e-04 | 3.314 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.934015e-04 | 3.307 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.445480e-04 | 3.264 |
| R-HSA-9033241 | Peroxisomal protein import | 5.758648e-04 | 3.240 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.758648e-04 | 3.240 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.972507e-04 | 3.224 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.084405e-04 | 3.216 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.084405e-04 | 3.216 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.084405e-04 | 3.216 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.084405e-04 | 3.216 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.084405e-04 | 3.216 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.423035e-04 | 3.192 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.774820e-04 | 3.169 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.915017e-04 | 3.160 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.915017e-04 | 3.160 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.140045e-04 | 3.146 |
| R-HSA-1640170 | Cell Cycle | 7.558492e-04 | 3.122 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.609951e-04 | 3.119 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.609951e-04 | 3.119 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.609951e-04 | 3.119 |
| R-HSA-1234174 | Cellular response to hypoxia | 7.911954e-04 | 3.102 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.316784e-04 | 3.080 |
| R-HSA-5693606 | DNA Double Strand Break Response | 8.741040e-04 | 3.058 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 8.741040e-04 | 3.058 |
| R-HSA-5218859 | Regulated Necrosis | 9.177739e-04 | 3.037 |
| R-HSA-5688426 | Deubiquitination | 9.193409e-04 | 3.037 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.387874e-04 | 3.027 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.786547e-04 | 3.009 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.009688e-03 | 2.996 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.009688e-03 | 2.996 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.047362e-03 | 2.980 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.057989e-03 | 2.976 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.057989e-03 | 2.976 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.057989e-03 | 2.976 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.057989e-03 | 2.976 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.107891e-03 | 2.956 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.110766e-03 | 2.954 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.159423e-03 | 2.936 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.159423e-03 | 2.936 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.212612e-03 | 2.916 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.212612e-03 | 2.916 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.267489e-03 | 2.897 |
| R-HSA-917937 | Iron uptake and transport | 1.267489e-03 | 2.897 |
| R-HSA-5689603 | UCH proteinases | 1.324080e-03 | 2.878 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.324080e-03 | 2.878 |
| R-HSA-9609690 | HCMV Early Events | 1.355171e-03 | 2.868 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.355171e-03 | 2.868 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.382415e-03 | 2.859 |
| R-HSA-9679506 | SARS-CoV Infections | 1.441079e-03 | 2.841 |
| R-HSA-4086400 | PCP/CE pathway | 1.442522e-03 | 2.841 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.508894e-03 | 2.821 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.568166e-03 | 2.805 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.569407e-03 | 2.804 |
| R-HSA-977225 | Amyloid fiber formation | 1.633759e-03 | 2.787 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.633759e-03 | 2.787 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.643526e-03 | 2.784 |
| R-HSA-112316 | Neuronal System | 1.691769e-03 | 2.772 |
| R-HSA-9824446 | Viral Infection Pathways | 1.708756e-03 | 2.767 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.841964e-03 | 2.735 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.841964e-03 | 2.735 |
| R-HSA-3371511 | HSF1 activation | 1.880807e-03 | 2.726 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.915268e-03 | 2.718 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.960520e-03 | 2.708 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.067896e-03 | 2.684 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.115055e-03 | 2.675 |
| R-HSA-70268 | Pyruvate metabolism | 2.147275e-03 | 2.668 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.172534e-03 | 2.663 |
| R-HSA-156902 | Peptide chain elongation | 2.228736e-03 | 2.652 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.231146e-03 | 2.651 |
| R-HSA-418990 | Adherens junctions interactions | 2.252568e-03 | 2.647 |
| R-HSA-8951664 | Neddylation | 2.396432e-03 | 2.620 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.413909e-03 | 2.617 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.485880e-03 | 2.605 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.668216e-03 | 2.574 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.668216e-03 | 2.574 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.674246e-03 | 2.573 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.742393e-03 | 2.562 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.762739e-03 | 2.559 |
| R-HSA-9609507 | Protein localization | 2.811790e-03 | 2.551 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.877117e-03 | 2.541 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.954392e-03 | 2.530 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.060044e-03 | 2.514 |
| R-HSA-162587 | HIV Life Cycle | 3.102158e-03 | 2.508 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.123943e-03 | 2.505 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.178011e-03 | 2.498 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.269963e-03 | 2.485 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.269963e-03 | 2.485 |
| R-HSA-190236 | Signaling by FGFR | 3.378516e-03 | 2.471 |
| R-HSA-157118 | Signaling by NOTCH | 3.474494e-03 | 2.459 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.718865e-03 | 2.430 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.837297e-03 | 2.416 |
| R-HSA-5620924 | Intraflagellar transport | 3.943521e-03 | 2.404 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.951084e-03 | 2.403 |
| R-HSA-192823 | Viral mRNA Translation | 3.958263e-03 | 2.402 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.081788e-03 | 2.389 |
| R-HSA-9609646 | HCMV Infection | 4.169551e-03 | 2.380 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 4.196459e-03 | 2.377 |
| R-HSA-9833110 | RSV-host interactions | 4.207898e-03 | 2.376 |
| R-HSA-199991 | Membrane Trafficking | 4.221235e-03 | 2.375 |
| R-HSA-421270 | Cell-cell junction organization | 4.244326e-03 | 2.372 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.336617e-03 | 2.363 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.385673e-03 | 2.358 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.482871e-03 | 2.348 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.601985e-03 | 2.337 |
| R-HSA-69239 | Synthesis of DNA | 4.601985e-03 | 2.337 |
| R-HSA-168256 | Immune System | 4.655686e-03 | 2.332 |
| R-HSA-2672351 | Stimuli-sensing channels | 4.738683e-03 | 2.324 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.783687e-03 | 2.320 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.878089e-03 | 2.312 |
| R-HSA-168255 | Influenza Infection | 5.206778e-03 | 2.283 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.224918e-03 | 2.282 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.616587e-03 | 2.251 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.093710e-03 | 2.215 |
| R-HSA-5693538 | Homology Directed Repair | 6.597113e-03 | 2.181 |
| R-HSA-446728 | Cell junction organization | 6.663026e-03 | 2.176 |
| R-HSA-392499 | Metabolism of proteins | 6.718459e-03 | 2.173 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.770859e-03 | 2.169 |
| R-HSA-3371556 | Cellular response to heat stress | 7.127399e-03 | 2.147 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.127399e-03 | 2.147 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.127399e-03 | 2.147 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.871965e-03 | 2.104 |
| R-HSA-69206 | G1/S Transition | 8.072542e-03 | 2.093 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.167292e-03 | 2.088 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.317809e-03 | 2.080 |
| R-HSA-114608 | Platelet degranulation | 8.472555e-03 | 2.072 |
| R-HSA-69481 | G2/M Checkpoints | 8.472555e-03 | 2.072 |
| R-HSA-9909396 | Circadian clock | 9.749976e-03 | 2.011 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.974368e-03 | 2.001 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.044766e-02 | 1.981 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.090545e-02 | 1.962 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.114669e-02 | 1.953 |
| R-HSA-1500931 | Cell-Cell communication | 1.158610e-02 | 1.936 |
| R-HSA-6807070 | PTEN Regulation | 1.163945e-02 | 1.934 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.169432e-02 | 1.932 |
| R-HSA-1266738 | Developmental Biology | 1.173560e-02 | 1.930 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.222247e-02 | 1.913 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 1.246978e-02 | 1.904 |
| R-HSA-162906 | HIV Infection | 1.273445e-02 | 1.895 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.375010e-02 | 1.862 |
| R-HSA-69242 | S Phase | 1.431330e-02 | 1.844 |
| R-HSA-166520 | Signaling by NTRKs | 1.431330e-02 | 1.844 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.492655e-02 | 1.826 |
| R-HSA-69306 | DNA Replication | 1.578483e-02 | 1.802 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.578483e-02 | 1.802 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.603234e-02 | 1.795 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.603234e-02 | 1.795 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 1.662881e-02 | 1.779 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 1.662881e-02 | 1.779 |
| R-HSA-9711097 | Cellular response to starvation | 1.734850e-02 | 1.761 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.745174e-02 | 1.758 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.757350e-02 | 1.755 |
| R-HSA-877300 | Interferon gamma signaling | 1.767243e-02 | 1.753 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.800013e-02 | 1.745 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.800013e-02 | 1.745 |
| R-HSA-109581 | Apoptosis | 1.866686e-02 | 1.729 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.934878e-02 | 1.713 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.069013e-02 | 1.684 |
| R-HSA-8953854 | Metabolism of RNA | 2.128039e-02 | 1.672 |
| R-HSA-390522 | Striated Muscle Contraction | 2.138673e-02 | 1.670 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.185642e-02 | 1.660 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 2.211075e-02 | 1.655 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 2.211075e-02 | 1.655 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 2.211075e-02 | 1.655 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 2.211075e-02 | 1.655 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 2.211075e-02 | 1.655 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 2.211075e-02 | 1.655 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 2.211075e-02 | 1.655 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 2.211075e-02 | 1.655 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 2.211075e-02 | 1.655 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 2.211075e-02 | 1.655 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 2.211075e-02 | 1.655 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.301870e-02 | 1.638 |
| R-HSA-597592 | Post-translational protein modification | 2.339043e-02 | 1.631 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.468259e-02 | 1.608 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.487191e-02 | 1.604 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.583636e-02 | 1.588 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.702156e-02 | 1.568 |
| R-HSA-5663205 | Infectious disease | 2.732962e-02 | 1.563 |
| R-HSA-449147 | Signaling by Interleukins | 2.830752e-02 | 1.548 |
| R-HSA-3371568 | Attenuation phase | 2.879692e-02 | 1.541 |
| R-HSA-202433 | Generation of second messenger molecules | 2.879692e-02 | 1.541 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.918706e-02 | 1.535 |
| R-HSA-983712 | Ion channel transport | 2.963221e-02 | 1.528 |
| R-HSA-5617833 | Cilium Assembly | 3.008139e-02 | 1.522 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.210560e-02 | 1.493 |
| R-HSA-109582 | Hemostasis | 3.612533e-02 | 1.442 |
| R-HSA-5357801 | Programmed Cell Death | 3.781984e-02 | 1.422 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.348008e-02 | 1.362 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 4.373793e-02 | 1.359 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 4.373793e-02 | 1.359 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.654094e-02 | 1.332 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.956310e-02 | 1.305 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.026207e-02 | 1.299 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.088069e-02 | 1.293 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 5.219461e-02 | 1.282 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.269772e-02 | 1.278 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.307509e-02 | 1.275 |
| R-HSA-72312 | rRNA processing | 5.324913e-02 | 1.274 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 5.437346e-02 | 1.265 |
| R-HSA-379724 | tRNA Aminoacylation | 5.594301e-02 | 1.252 |
| R-HSA-390696 | Adrenoceptors | 5.964728e-02 | 1.224 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.034451e-02 | 1.219 |
| R-HSA-73894 | DNA Repair | 6.224127e-02 | 1.206 |
| R-HSA-9683686 | Maturation of spike protein | 7.010780e-02 | 1.154 |
| R-HSA-168249 | Innate Immune System | 7.291632e-02 | 1.137 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 7.529483e-02 | 1.123 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 7.529483e-02 | 1.123 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.083184e-02 | 1.092 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.398020e-02 | 1.076 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 8.558319e-02 | 1.068 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 8.558319e-02 | 1.068 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 8.558319e-02 | 1.068 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 8.558319e-02 | 1.068 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 8.564356e-02 | 1.067 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.900015e-02 | 1.051 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.537728e-02 | 1.021 |
| R-HSA-1663150 | The activation of arylsulfatases | 9.575835e-02 | 1.019 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.008039e-01 | 0.997 |
| R-HSA-8876725 | Protein methylation | 1.008039e-01 | 0.997 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.013967e-01 | 0.994 |
| R-HSA-195721 | Signaling by WNT | 1.031485e-01 | 0.987 |
| R-HSA-9678110 | Attachment and Entry | 1.058215e-01 | 0.975 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.157739e-01 | 0.936 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.157739e-01 | 0.936 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.207090e-01 | 0.918 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.207090e-01 | 0.918 |
| R-HSA-70171 | Glycolysis | 1.282163e-01 | 0.892 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 1.304975e-01 | 0.884 |
| R-HSA-9694614 | Attachment and Entry | 1.401783e-01 | 0.853 |
| R-HSA-397014 | Muscle contraction | 1.409346e-01 | 0.851 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.449786e-01 | 0.839 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 1.497524e-01 | 0.825 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.501831e-01 | 0.823 |
| R-HSA-429947 | Deadenylation of mRNA | 1.544999e-01 | 0.811 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.544999e-01 | 0.811 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.544999e-01 | 0.811 |
| R-HSA-388396 | GPCR downstream signalling | 1.567271e-01 | 0.805 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.592212e-01 | 0.798 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.639163e-01 | 0.785 |
| R-HSA-525793 | Myogenesis | 1.639163e-01 | 0.785 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 1.639163e-01 | 0.785 |
| R-HSA-70326 | Glucose metabolism | 1.666696e-01 | 0.778 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.666696e-01 | 0.778 |
| R-HSA-8949613 | Cristae formation | 1.685856e-01 | 0.773 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.685856e-01 | 0.773 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.685856e-01 | 0.773 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.778469e-01 | 0.750 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.824392e-01 | 0.739 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.824392e-01 | 0.739 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.870061e-01 | 0.728 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.870061e-01 | 0.728 |
| R-HSA-186763 | Downstream signal transduction | 1.870061e-01 | 0.728 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.960645e-01 | 0.708 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.960645e-01 | 0.708 |
| R-HSA-354192 | Integrin signaling | 1.960645e-01 | 0.708 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.005561e-01 | 0.698 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.005561e-01 | 0.698 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.005561e-01 | 0.698 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 2.005561e-01 | 0.698 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.050230e-01 | 0.688 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.094651e-01 | 0.679 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.094651e-01 | 0.679 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.108881e-01 | 0.676 |
| R-HSA-163685 | Integration of energy metabolism | 2.108881e-01 | 0.676 |
| R-HSA-416476 | G alpha (q) signalling events | 2.124015e-01 | 0.673 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.182760e-01 | 0.661 |
| R-HSA-372790 | Signaling by GPCR | 2.198812e-01 | 0.658 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.226449e-01 | 0.652 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.269897e-01 | 0.644 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.269897e-01 | 0.644 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.313104e-01 | 0.636 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.313104e-01 | 0.636 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.313104e-01 | 0.636 |
| R-HSA-5260271 | Diseases of Immune System | 2.313104e-01 | 0.636 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.313104e-01 | 0.636 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 2.313104e-01 | 0.636 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.343503e-01 | 0.630 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.356073e-01 | 0.628 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.356073e-01 | 0.628 |
| R-HSA-9694548 | Maturation of spike protein | 2.356073e-01 | 0.628 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.356073e-01 | 0.628 |
| R-HSA-5668914 | Diseases of metabolism | 2.417293e-01 | 0.617 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.441299e-01 | 0.612 |
| R-HSA-165159 | MTOR signalling | 2.441299e-01 | 0.612 |
| R-HSA-375280 | Amine ligand-binding receptors | 2.525586e-01 | 0.598 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.525586e-01 | 0.598 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.567380e-01 | 0.591 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.567380e-01 | 0.591 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.608943e-01 | 0.584 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.650276e-01 | 0.577 |
| R-HSA-70263 | Gluconeogenesis | 2.691380e-01 | 0.570 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.885100e-01 | 0.540 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.893517e-01 | 0.539 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.051238e-01 | 0.516 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.090124e-01 | 0.510 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.128795e-01 | 0.505 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.128795e-01 | 0.505 |
| R-HSA-191859 | snRNP Assembly | 3.128795e-01 | 0.505 |
| R-HSA-156590 | Glutathione conjugation | 3.167252e-01 | 0.499 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.205496e-01 | 0.494 |
| R-HSA-1268020 | Mitochondrial protein import | 3.243528e-01 | 0.489 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.243528e-01 | 0.489 |
| R-HSA-186797 | Signaling by PDGF | 3.243528e-01 | 0.489 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.243528e-01 | 0.489 |
| R-HSA-1643685 | Disease | 3.257990e-01 | 0.487 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.281350e-01 | 0.484 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.281350e-01 | 0.484 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.343784e-01 | 0.476 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.393564e-01 | 0.469 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.540304e-01 | 0.451 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 3.540304e-01 | 0.451 |
| R-HSA-72172 | mRNA Splicing | 3.566881e-01 | 0.448 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.576483e-01 | 0.447 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.612461e-01 | 0.442 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.648240e-01 | 0.438 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.648240e-01 | 0.438 |
| R-HSA-380287 | Centrosome maturation | 3.719204e-01 | 0.430 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.961460e-01 | 0.402 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.128819e-01 | 0.384 |
| R-HSA-8939211 | ESR-mediated signaling | 4.218575e-01 | 0.375 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.259397e-01 | 0.371 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.355442e-01 | 0.361 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.418588e-01 | 0.355 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.573412e-01 | 0.340 |
| R-HSA-1483255 | PI Metabolism | 4.694206e-01 | 0.328 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.753602e-01 | 0.323 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.811560e-01 | 0.318 |
| R-HSA-211000 | Gene Silencing by RNA | 4.870429e-01 | 0.312 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.012851e-01 | 0.300 |
| R-HSA-6798695 | Neutrophil degranulation | 5.018780e-01 | 0.299 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.068718e-01 | 0.295 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.096420e-01 | 0.293 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.151361e-01 | 0.288 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.232634e-01 | 0.281 |
| R-HSA-68875 | Mitotic Prophase | 5.286066e-01 | 0.277 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.365105e-01 | 0.270 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 5.365105e-01 | 0.270 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.391159e-01 | 0.268 |
| R-HSA-194138 | Signaling by VEGF | 5.442834e-01 | 0.264 |
| R-HSA-8957322 | Metabolism of steroids | 5.754464e-01 | 0.240 |
| R-HSA-9610379 | HCMV Late Events | 6.259748e-01 | 0.203 |
| R-HSA-5619102 | SLC transporter disorders | 6.465291e-01 | 0.189 |
| R-HSA-72306 | tRNA processing | 6.544344e-01 | 0.184 |
| R-HSA-418555 | G alpha (s) signalling events | 6.563833e-01 | 0.183 |
| R-HSA-382551 | Transport of small molecules | 6.656870e-01 | 0.177 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 6.775292e-01 | 0.169 |
| R-HSA-428157 | Sphingolipid metabolism | 7.100542e-01 | 0.149 |
| R-HSA-6805567 | Keratinization | 7.197480e-01 | 0.143 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.306531e-01 | 0.136 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.554205e-01 | 0.122 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.609127e-01 | 0.119 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 7.676067e-01 | 0.115 |
| R-HSA-4839726 | Chromatin organization | 7.804435e-01 | 0.108 |
| R-HSA-1483257 | Phospholipid metabolism | 8.310224e-01 | 0.080 |
| R-HSA-500792 | GPCR ligand binding | 8.594019e-01 | 0.066 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.860719e-01 | 0.053 |
| R-HSA-418594 | G alpha (i) signalling events | 9.114746e-01 | 0.040 |
| R-HSA-8978868 | Fatty acid metabolism | 9.114746e-01 | 0.040 |
| R-HSA-211859 | Biological oxidations | 9.546330e-01 | 0.020 |
| R-HSA-556833 | Metabolism of lipids | 9.739074e-01 | 0.011 |
| R-HSA-1430728 | Metabolism | 9.742573e-01 | 0.011 |
| R-HSA-212436 | Generic Transcription Pathway | 9.801520e-01 | 0.009 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.893858e-01 | 0.005 |
| R-HSA-74160 | Gene expression (Transcription) | 9.899930e-01 | 0.004 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.790 | 0.314 | 1 | 0.748 |
CDKL5 |
0.789 | 0.370 | -3 | 0.762 |
CDKL1 |
0.781 | 0.313 | -3 | 0.758 |
CLK3 |
0.781 | 0.201 | 1 | 0.767 |
SRPK1 |
0.781 | 0.200 | -3 | 0.736 |
COT |
0.779 | 0.110 | 2 | 0.838 |
ICK |
0.775 | 0.356 | -3 | 0.767 |
NDR2 |
0.774 | 0.122 | -3 | 0.719 |
MAK |
0.772 | 0.425 | -2 | 0.882 |
PIM3 |
0.771 | 0.138 | -3 | 0.738 |
SKMLCK |
0.771 | 0.165 | -2 | 0.689 |
CDC7 |
0.770 | 0.070 | 1 | 0.821 |
CHAK2 |
0.770 | 0.188 | -1 | 0.762 |
MTOR |
0.767 | 0.097 | 1 | 0.735 |
WNK1 |
0.767 | 0.109 | -2 | 0.715 |
HIPK2 |
0.767 | 0.198 | 1 | 0.538 |
RSK2 |
0.767 | 0.125 | -3 | 0.739 |
AURC |
0.766 | 0.100 | -2 | 0.490 |
DYRK2 |
0.765 | 0.153 | 1 | 0.643 |
NUAK2 |
0.765 | 0.101 | -3 | 0.751 |
NDR1 |
0.764 | 0.077 | -3 | 0.723 |
PRKD1 |
0.764 | 0.133 | -3 | 0.731 |
SRPK2 |
0.764 | 0.153 | -3 | 0.681 |
RAF1 |
0.764 | 0.035 | 1 | 0.806 |
ATR |
0.763 | 0.088 | 1 | 0.820 |
CAMK1B |
0.763 | 0.083 | -3 | 0.762 |
SRPK3 |
0.763 | 0.152 | -3 | 0.709 |
PRKD2 |
0.763 | 0.137 | -3 | 0.709 |
MOS |
0.763 | 0.088 | 1 | 0.840 |
MARK4 |
0.763 | 0.095 | 4 | 0.828 |
TSSK1 |
0.763 | 0.145 | -3 | 0.751 |
KIS |
0.762 | 0.056 | 1 | 0.610 |
AMPKA1 |
0.762 | 0.112 | -3 | 0.738 |
RSK3 |
0.762 | 0.109 | -3 | 0.718 |
ERK5 |
0.761 | 0.134 | 1 | 0.771 |
NLK |
0.761 | 0.067 | 1 | 0.756 |
PRPK |
0.761 | -0.003 | -1 | 0.739 |
QSK |
0.760 | 0.128 | 4 | 0.823 |
PKN2 |
0.760 | 0.085 | -3 | 0.732 |
HIPK1 |
0.760 | 0.177 | 1 | 0.653 |
RIPK3 |
0.760 | 0.056 | 3 | 0.620 |
P90RSK |
0.759 | 0.118 | -3 | 0.729 |
IKKB |
0.759 | -0.066 | -2 | 0.555 |
PKACB |
0.759 | 0.113 | -2 | 0.493 |
PKACG |
0.759 | 0.064 | -2 | 0.555 |
MPSK1 |
0.758 | 0.345 | 1 | 0.732 |
PKCD |
0.758 | 0.113 | 2 | 0.694 |
TBK1 |
0.758 | 0.021 | 1 | 0.709 |
AMPKA2 |
0.758 | 0.111 | -3 | 0.724 |
PIM1 |
0.758 | 0.119 | -3 | 0.722 |
IRE1 |
0.757 | 0.106 | 1 | 0.819 |
MST4 |
0.757 | 0.055 | 2 | 0.781 |
CDK19 |
0.757 | 0.131 | 1 | 0.518 |
HUNK |
0.757 | -0.009 | 2 | 0.798 |
GRK1 |
0.756 | 0.055 | -2 | 0.667 |
CDK8 |
0.756 | 0.111 | 1 | 0.564 |
CLK2 |
0.756 | 0.159 | -3 | 0.701 |
GCN2 |
0.756 | -0.115 | 2 | 0.753 |
MOK |
0.756 | 0.335 | 1 | 0.707 |
PAK1 |
0.756 | 0.084 | -2 | 0.638 |
LATS2 |
0.756 | 0.040 | -5 | 0.588 |
CAMLCK |
0.755 | 0.073 | -2 | 0.654 |
ULK2 |
0.755 | -0.056 | 2 | 0.715 |
MAPKAPK3 |
0.755 | 0.086 | -3 | 0.697 |
PKCG |
0.754 | 0.107 | 2 | 0.649 |
PDHK4 |
0.754 | -0.145 | 1 | 0.815 |
PKN3 |
0.754 | 0.057 | -3 | 0.728 |
DYRK1A |
0.754 | 0.205 | 1 | 0.657 |
P38B |
0.754 | 0.182 | 1 | 0.553 |
TSSK2 |
0.754 | 0.076 | -5 | 0.619 |
DAPK2 |
0.754 | 0.085 | -3 | 0.761 |
CDK7 |
0.754 | 0.094 | 1 | 0.566 |
PKCB |
0.754 | 0.115 | 2 | 0.633 |
P38A |
0.754 | 0.190 | 1 | 0.619 |
TGFBR2 |
0.754 | -0.032 | -2 | 0.579 |
AKT2 |
0.753 | 0.137 | -3 | 0.693 |
CDK18 |
0.753 | 0.117 | 1 | 0.497 |
PAK3 |
0.753 | 0.057 | -2 | 0.615 |
NIK |
0.753 | 0.058 | -3 | 0.734 |
P70S6KB |
0.753 | 0.070 | -3 | 0.729 |
PKCA |
0.752 | 0.117 | 2 | 0.622 |
RSK4 |
0.752 | 0.116 | -3 | 0.706 |
MLK1 |
0.752 | 0.020 | 2 | 0.723 |
PRKX |
0.752 | 0.104 | -3 | 0.659 |
CLK4 |
0.752 | 0.108 | -3 | 0.722 |
HIPK3 |
0.752 | 0.160 | 1 | 0.647 |
MNK2 |
0.752 | 0.078 | -2 | 0.590 |
DSTYK |
0.752 | -0.084 | 2 | 0.823 |
IKKE |
0.752 | -0.041 | 1 | 0.704 |
RIPK1 |
0.752 | 0.026 | 1 | 0.846 |
SGK3 |
0.751 | 0.125 | -3 | 0.718 |
CLK1 |
0.751 | 0.119 | -3 | 0.708 |
MAPKAPK2 |
0.751 | 0.095 | -3 | 0.675 |
PKG2 |
0.750 | 0.070 | -2 | 0.500 |
CDK5 |
0.750 | 0.112 | 1 | 0.586 |
NIM1 |
0.750 | 0.040 | 3 | 0.664 |
QIK |
0.750 | 0.044 | -3 | 0.735 |
BMPR2 |
0.750 | -0.139 | -2 | 0.673 |
PKCZ |
0.750 | 0.112 | 2 | 0.687 |
NEK6 |
0.750 | -0.042 | -2 | 0.632 |
CAMK2D |
0.749 | 0.018 | -3 | 0.735 |
MARK3 |
0.749 | 0.085 | 4 | 0.780 |
GRK5 |
0.749 | -0.072 | -3 | 0.709 |
WNK3 |
0.749 | -0.063 | 1 | 0.799 |
SIK |
0.749 | 0.088 | -3 | 0.688 |
PDHK1 |
0.749 | -0.143 | 1 | 0.808 |
PRKD3 |
0.749 | 0.100 | -3 | 0.707 |
ERK1 |
0.748 | 0.138 | 1 | 0.527 |
DYRK4 |
0.748 | 0.113 | 1 | 0.545 |
CK1E |
0.748 | 0.072 | -3 | 0.505 |
CAMK2G |
0.748 | -0.094 | 2 | 0.807 |
AURB |
0.748 | 0.046 | -2 | 0.481 |
MNK1 |
0.748 | 0.071 | -2 | 0.596 |
MSK2 |
0.747 | 0.065 | -3 | 0.712 |
CDK1 |
0.747 | 0.080 | 1 | 0.537 |
MLK2 |
0.747 | 0.089 | 2 | 0.728 |
BRSK1 |
0.746 | 0.072 | -3 | 0.702 |
BRSK2 |
0.746 | 0.054 | -3 | 0.709 |
MLK3 |
0.746 | 0.082 | 2 | 0.645 |
DYRK3 |
0.746 | 0.132 | 1 | 0.674 |
MSK1 |
0.746 | 0.076 | -3 | 0.709 |
NUAK1 |
0.746 | 0.045 | -3 | 0.700 |
NEK7 |
0.746 | -0.133 | -3 | 0.666 |
TTBK2 |
0.746 | -0.020 | 2 | 0.690 |
MYLK4 |
0.745 | 0.050 | -2 | 0.580 |
PKR |
0.745 | 0.108 | 1 | 0.847 |
MELK |
0.745 | 0.062 | -3 | 0.714 |
PAK6 |
0.745 | 0.039 | -2 | 0.524 |
DLK |
0.744 | -0.000 | 1 | 0.833 |
PIM2 |
0.744 | 0.109 | -3 | 0.718 |
BMPR1B |
0.743 | 0.035 | 1 | 0.791 |
MASTL |
0.743 | -0.095 | -2 | 0.632 |
CHAK1 |
0.743 | 0.058 | 2 | 0.693 |
PKACA |
0.743 | 0.082 | -2 | 0.446 |
MARK2 |
0.742 | 0.048 | 4 | 0.769 |
IKKA |
0.742 | -0.062 | -2 | 0.563 |
PAK2 |
0.742 | 0.013 | -2 | 0.613 |
LATS1 |
0.741 | 0.071 | -3 | 0.721 |
AKT1 |
0.741 | 0.110 | -3 | 0.695 |
SSTK |
0.741 | 0.092 | 4 | 0.823 |
JNK2 |
0.741 | 0.077 | 1 | 0.509 |
NEK9 |
0.741 | -0.069 | 2 | 0.757 |
PHKG1 |
0.740 | 0.036 | -3 | 0.714 |
PKCH |
0.740 | 0.046 | 2 | 0.614 |
BCKDK |
0.740 | -0.125 | -1 | 0.668 |
WNK4 |
0.740 | 0.074 | -2 | 0.714 |
CAMK1G |
0.740 | 0.072 | -3 | 0.711 |
P38G |
0.739 | 0.074 | 1 | 0.442 |
ULK1 |
0.739 | -0.139 | -3 | 0.623 |
CDK13 |
0.739 | 0.026 | 1 | 0.539 |
CAMK4 |
0.739 | -0.038 | -3 | 0.713 |
CAMK2A |
0.739 | 0.034 | 2 | 0.816 |
IRE2 |
0.739 | 0.022 | 2 | 0.623 |
DCAMKL1 |
0.738 | 0.088 | -3 | 0.696 |
GRK4 |
0.738 | -0.118 | -2 | 0.659 |
AURA |
0.738 | 0.007 | -2 | 0.459 |
CDK12 |
0.738 | 0.044 | 1 | 0.514 |
JNK3 |
0.738 | 0.044 | 1 | 0.556 |
CK1D |
0.737 | 0.049 | -3 | 0.468 |
DYRK1B |
0.737 | 0.082 | 1 | 0.574 |
CDK3 |
0.737 | 0.084 | 1 | 0.465 |
MARK1 |
0.737 | 0.028 | 4 | 0.800 |
GRK7 |
0.737 | 0.021 | 1 | 0.748 |
ANKRD3 |
0.737 | -0.106 | 1 | 0.855 |
VRK2 |
0.737 | 0.067 | 1 | 0.856 |
CK1G1 |
0.736 | 0.028 | -3 | 0.473 |
CDK17 |
0.736 | 0.056 | 1 | 0.447 |
CAMK2B |
0.736 | -0.004 | 2 | 0.802 |
PKCT |
0.735 | 0.073 | 2 | 0.621 |
GRK6 |
0.735 | -0.113 | 1 | 0.834 |
CDK10 |
0.735 | 0.084 | 1 | 0.527 |
MLK4 |
0.735 | 0.027 | 2 | 0.628 |
P38D |
0.735 | 0.094 | 1 | 0.449 |
CDK14 |
0.735 | 0.077 | 1 | 0.538 |
PRP4 |
0.735 | 0.053 | -3 | 0.603 |
SMG1 |
0.735 | -0.014 | 1 | 0.768 |
PKCE |
0.735 | 0.099 | 2 | 0.622 |
AKT3 |
0.734 | 0.121 | -3 | 0.656 |
MST3 |
0.734 | 0.090 | 2 | 0.758 |
IRAK4 |
0.734 | 0.069 | 1 | 0.825 |
BUB1 |
0.733 | 0.163 | -5 | 0.627 |
CK1A2 |
0.733 | 0.037 | -3 | 0.476 |
ATM |
0.732 | -0.042 | 1 | 0.764 |
PKCI |
0.732 | 0.056 | 2 | 0.649 |
MEK1 |
0.732 | -0.087 | 2 | 0.797 |
ALK4 |
0.732 | -0.074 | -2 | 0.623 |
MAPKAPK5 |
0.732 | 0.004 | -3 | 0.680 |
FAM20C |
0.732 | -0.017 | 2 | 0.588 |
TGFBR1 |
0.731 | -0.047 | -2 | 0.600 |
PASK |
0.731 | 0.083 | -3 | 0.758 |
ERK2 |
0.731 | 0.043 | 1 | 0.583 |
CDK9 |
0.731 | -0.002 | 1 | 0.547 |
SNRK |
0.731 | -0.073 | 2 | 0.604 |
NEK2 |
0.730 | -0.056 | 2 | 0.723 |
PAK5 |
0.729 | 0.022 | -2 | 0.484 |
CDK2 |
0.729 | 0.002 | 1 | 0.632 |
SMMLCK |
0.729 | 0.035 | -3 | 0.748 |
DNAPK |
0.729 | 0.010 | 1 | 0.665 |
DRAK1 |
0.728 | -0.006 | 1 | 0.788 |
MEKK1 |
0.728 | -0.004 | 1 | 0.811 |
SGK1 |
0.727 | 0.118 | -3 | 0.642 |
PLK4 |
0.727 | -0.050 | 2 | 0.597 |
YSK4 |
0.727 | -0.092 | 1 | 0.748 |
GRK2 |
0.727 | -0.052 | -2 | 0.570 |
TLK2 |
0.726 | -0.070 | 1 | 0.784 |
P70S6K |
0.726 | 0.038 | -3 | 0.692 |
DCAMKL2 |
0.726 | 0.040 | -3 | 0.711 |
PDK1 |
0.726 | 0.085 | 1 | 0.793 |
PAK4 |
0.726 | 0.023 | -2 | 0.489 |
TAO3 |
0.725 | 0.040 | 1 | 0.772 |
MEK5 |
0.725 | -0.059 | 2 | 0.755 |
CAMK1D |
0.725 | 0.067 | -3 | 0.648 |
PHKG2 |
0.725 | 0.012 | -3 | 0.714 |
PERK |
0.725 | -0.087 | -2 | 0.614 |
ACVR2B |
0.725 | -0.075 | -2 | 0.581 |
CDK16 |
0.724 | 0.060 | 1 | 0.460 |
HASPIN |
0.724 | 0.201 | -1 | 0.750 |
CDK4 |
0.724 | 0.075 | 1 | 0.497 |
ZAK |
0.724 | -0.043 | 1 | 0.801 |
ACVR2A |
0.724 | -0.090 | -2 | 0.564 |
ROCK2 |
0.723 | 0.117 | -3 | 0.711 |
MEKK3 |
0.723 | -0.081 | 1 | 0.799 |
PLK1 |
0.723 | -0.139 | -2 | 0.574 |
DAPK3 |
0.723 | 0.059 | -3 | 0.722 |
PINK1 |
0.723 | -0.103 | 1 | 0.772 |
ALK2 |
0.723 | -0.076 | -2 | 0.608 |
BRAF |
0.723 | -0.061 | -4 | 0.687 |
CDK6 |
0.723 | 0.062 | 1 | 0.511 |
NEK5 |
0.723 | -0.015 | 1 | 0.823 |
MEKK6 |
0.722 | 0.104 | 1 | 0.785 |
PKN1 |
0.722 | 0.073 | -3 | 0.706 |
LKB1 |
0.722 | 0.052 | -3 | 0.651 |
CHK2 |
0.722 | 0.099 | -3 | 0.650 |
CHK1 |
0.722 | -0.062 | -3 | 0.677 |
MEKK2 |
0.722 | -0.020 | 2 | 0.719 |
MRCKB |
0.721 | 0.085 | -3 | 0.696 |
MAP3K15 |
0.721 | 0.124 | 1 | 0.767 |
ERK7 |
0.721 | 0.047 | 2 | 0.468 |
TTBK1 |
0.720 | -0.066 | 2 | 0.630 |
STK33 |
0.720 | 0.005 | 2 | 0.638 |
CAMK1A |
0.719 | 0.087 | -3 | 0.642 |
BMPR1A |
0.718 | -0.040 | 1 | 0.768 |
CAMKK1 |
0.718 | -0.058 | -2 | 0.554 |
EEF2K |
0.718 | 0.086 | 3 | 0.766 |
HRI |
0.718 | -0.141 | -2 | 0.624 |
GRK3 |
0.717 | -0.053 | -2 | 0.542 |
TLK1 |
0.717 | -0.112 | -2 | 0.626 |
TNIK |
0.717 | 0.093 | 3 | 0.796 |
PLK3 |
0.716 | -0.128 | 2 | 0.794 |
JNK1 |
0.716 | 0.021 | 1 | 0.499 |
PKG1 |
0.716 | 0.036 | -2 | 0.426 |
CAMKK2 |
0.716 | -0.037 | -2 | 0.552 |
GCK |
0.716 | 0.060 | 1 | 0.756 |
HPK1 |
0.715 | 0.051 | 1 | 0.747 |
DAPK1 |
0.715 | 0.037 | -3 | 0.729 |
LRRK2 |
0.715 | 0.053 | 2 | 0.776 |
NEK11 |
0.715 | -0.046 | 1 | 0.785 |
TAO2 |
0.714 | -0.004 | 2 | 0.757 |
IRAK1 |
0.714 | -0.142 | -1 | 0.661 |
DMPK1 |
0.714 | 0.100 | -3 | 0.712 |
HGK |
0.714 | 0.044 | 3 | 0.789 |
KHS1 |
0.713 | 0.097 | 1 | 0.743 |
VRK1 |
0.713 | 0.077 | 2 | 0.753 |
NEK8 |
0.713 | -0.082 | 2 | 0.725 |
MINK |
0.713 | 0.035 | 1 | 0.764 |
GAK |
0.713 | -0.026 | 1 | 0.777 |
KHS2 |
0.713 | 0.088 | 1 | 0.747 |
NEK4 |
0.711 | -0.034 | 1 | 0.777 |
MRCKA |
0.710 | 0.036 | -3 | 0.690 |
ROCK1 |
0.710 | 0.088 | -3 | 0.691 |
NEK1 |
0.710 | 0.026 | 1 | 0.806 |
CK1A |
0.710 | 0.034 | -3 | 0.390 |
SBK |
0.709 | 0.095 | -3 | 0.615 |
LOK |
0.708 | 0.000 | -2 | 0.561 |
CRIK |
0.707 | 0.086 | -3 | 0.704 |
TAK1 |
0.706 | -0.045 | 1 | 0.782 |
PBK |
0.706 | 0.016 | 1 | 0.688 |
YSK1 |
0.706 | 0.020 | 2 | 0.716 |
GSK3A |
0.705 | -0.017 | 4 | 0.281 |
YANK3 |
0.704 | 0.028 | 2 | 0.481 |
GSK3B |
0.704 | -0.054 | 4 | 0.277 |
SLK |
0.702 | -0.045 | -2 | 0.531 |
MST2 |
0.701 | -0.098 | 1 | 0.778 |
OSR1 |
0.699 | 0.023 | 2 | 0.740 |
MYO3B |
0.699 | 0.067 | 2 | 0.720 |
MST1 |
0.699 | -0.059 | 1 | 0.769 |
MEK2 |
0.698 | -0.109 | 2 | 0.742 |
NEK3 |
0.698 | -0.051 | 1 | 0.760 |
CK2A2 |
0.696 | -0.067 | 1 | 0.707 |
RIPK2 |
0.694 | -0.168 | 1 | 0.753 |
PDHK3_TYR |
0.693 | 0.157 | 4 | 0.800 |
PLK2 |
0.693 | -0.099 | -3 | 0.531 |
ASK1 |
0.692 | 0.027 | 1 | 0.756 |
LIMK2_TYR |
0.691 | 0.169 | -3 | 0.724 |
TTK |
0.691 | -0.034 | -2 | 0.607 |
PKMYT1_TYR |
0.689 | 0.074 | 3 | 0.740 |
CK2A1 |
0.688 | -0.070 | 1 | 0.691 |
TAO1 |
0.688 | -0.005 | 1 | 0.714 |
TESK1_TYR |
0.688 | 0.066 | 3 | 0.765 |
MAP2K4_TYR |
0.688 | 0.050 | -1 | 0.756 |
MYO3A |
0.687 | -0.010 | 1 | 0.783 |
TNK2 |
0.684 | 0.128 | 3 | 0.651 |
PDHK4_TYR |
0.683 | 0.017 | 2 | 0.843 |
MAP2K6_TYR |
0.682 | -0.015 | -1 | 0.747 |
ABL2 |
0.682 | 0.087 | -1 | 0.656 |
EPHA6 |
0.682 | 0.055 | -1 | 0.658 |
PDHK1_TYR |
0.681 | 0.009 | -1 | 0.741 |
BIKE |
0.681 | -0.029 | 1 | 0.632 |
MAP2K7_TYR |
0.680 | -0.085 | 2 | 0.803 |
EPHB4 |
0.680 | 0.090 | -1 | 0.641 |
TNNI3K_TYR |
0.680 | 0.116 | 1 | 0.843 |
BMPR2_TYR |
0.679 | -0.058 | -1 | 0.701 |
CK1G3 |
0.678 | -0.013 | -3 | 0.353 |
TXK |
0.678 | 0.100 | 1 | 0.830 |
CSF1R |
0.678 | 0.043 | 3 | 0.699 |
PINK1_TYR |
0.678 | -0.088 | 1 | 0.824 |
ABL1 |
0.677 | 0.066 | -1 | 0.654 |
LIMK1_TYR |
0.676 | -0.019 | 2 | 0.768 |
ALPHAK3 |
0.676 | -0.079 | -1 | 0.626 |
TNK1 |
0.676 | 0.103 | 3 | 0.690 |
TYRO3 |
0.675 | -0.013 | 3 | 0.699 |
RET |
0.675 | -0.025 | 1 | 0.801 |
ITK |
0.674 | 0.049 | -1 | 0.618 |
MST1R |
0.674 | -0.024 | 3 | 0.706 |
JAK2 |
0.674 | 0.010 | 1 | 0.792 |
ROS1 |
0.674 | 0.015 | 3 | 0.668 |
TYK2 |
0.673 | -0.056 | 1 | 0.796 |
YANK2 |
0.673 | -0.000 | 2 | 0.488 |
FGR |
0.672 | -0.021 | 1 | 0.831 |
DDR1 |
0.672 | -0.053 | 4 | 0.743 |
BLK |
0.669 | 0.033 | -1 | 0.645 |
YES1 |
0.669 | -0.018 | -1 | 0.696 |
STLK3 |
0.669 | -0.112 | 1 | 0.756 |
LCK |
0.668 | 0.008 | -1 | 0.633 |
AAK1 |
0.668 | 0.001 | 1 | 0.516 |
KIT |
0.667 | -0.041 | 3 | 0.699 |
EPHA4 |
0.667 | -0.003 | 2 | 0.801 |
MET |
0.667 | -0.010 | 3 | 0.681 |
SRMS |
0.666 | -0.026 | 1 | 0.843 |
HCK |
0.665 | -0.040 | -1 | 0.640 |
FLT3 |
0.665 | -0.058 | 3 | 0.711 |
PDGFRB |
0.665 | -0.073 | 3 | 0.707 |
EPHB1 |
0.664 | -0.030 | 1 | 0.852 |
FER |
0.664 | -0.098 | 1 | 0.839 |
JAK1 |
0.664 | 0.001 | 1 | 0.739 |
BMX |
0.663 | 0.014 | -1 | 0.543 |
DDR2 |
0.663 | 0.064 | 3 | 0.606 |
CK1G2 |
0.663 | -0.019 | -3 | 0.414 |
EPHB2 |
0.663 | -0.002 | -1 | 0.603 |
EPHB3 |
0.663 | -0.014 | -1 | 0.616 |
WEE1_TYR |
0.662 | -0.022 | -1 | 0.618 |
JAK3 |
0.662 | -0.098 | 1 | 0.791 |
KDR |
0.662 | -0.064 | 3 | 0.650 |
BTK |
0.661 | -0.059 | -1 | 0.607 |
TEC |
0.660 | -0.041 | -1 | 0.581 |
EPHA7 |
0.659 | 0.002 | 2 | 0.795 |
AXL |
0.659 | -0.058 | 3 | 0.638 |
MERTK |
0.659 | -0.036 | 3 | 0.647 |
NEK10_TYR |
0.659 | -0.047 | 1 | 0.638 |
PTK2B |
0.658 | 0.003 | -1 | 0.626 |
FRK |
0.658 | -0.030 | -1 | 0.654 |
INSRR |
0.657 | -0.117 | 3 | 0.621 |
FGFR2 |
0.657 | -0.122 | 3 | 0.647 |
PDGFRA |
0.656 | -0.109 | 3 | 0.710 |
TEK |
0.656 | -0.120 | 3 | 0.627 |
EPHA1 |
0.655 | -0.023 | 3 | 0.663 |
FLT1 |
0.654 | -0.087 | -1 | 0.635 |
ALK |
0.654 | -0.085 | 3 | 0.622 |
FYN |
0.653 | -0.034 | -1 | 0.609 |
MATK |
0.653 | -0.057 | -1 | 0.597 |
LTK |
0.653 | -0.083 | 3 | 0.641 |
EPHA3 |
0.652 | -0.072 | 2 | 0.764 |
LYN |
0.652 | -0.069 | 3 | 0.629 |
FGFR1 |
0.651 | -0.145 | 3 | 0.631 |
CSK |
0.651 | -0.030 | 2 | 0.783 |
PTK2 |
0.650 | -0.003 | -1 | 0.563 |
ERBB2 |
0.648 | -0.133 | 1 | 0.752 |
SRC |
0.647 | -0.061 | -1 | 0.625 |
EPHA8 |
0.646 | -0.049 | -1 | 0.587 |
NTRK1 |
0.646 | -0.176 | -1 | 0.650 |
PTK6 |
0.646 | -0.165 | -1 | 0.587 |
INSR |
0.645 | -0.120 | 3 | 0.612 |
NTRK3 |
0.644 | -0.109 | -1 | 0.607 |
EPHA5 |
0.644 | -0.073 | 2 | 0.779 |
FGFR3 |
0.643 | -0.151 | 3 | 0.620 |
FLT4 |
0.643 | -0.165 | 3 | 0.629 |
SYK |
0.641 | -0.050 | -1 | 0.555 |
FGFR4 |
0.640 | -0.086 | -1 | 0.591 |
EGFR |
0.638 | -0.091 | 1 | 0.686 |
NTRK2 |
0.638 | -0.219 | 3 | 0.620 |
EPHA2 |
0.636 | -0.067 | -1 | 0.546 |
ERBB4 |
0.632 | -0.070 | 1 | 0.700 |
ZAP70 |
0.631 | -0.029 | -1 | 0.503 |
MUSK |
0.631 | -0.120 | 1 | 0.674 |
IGF1R |
0.627 | -0.150 | 3 | 0.549 |
FES |
0.622 | -0.110 | -1 | 0.528 |