Motif 273 (n=177)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EW31 | PROB1 | S865 | ochoa | Proline-rich basic protein 1 | None |
| O00192 | ARVCF | Y201 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00425 | IGF2BP3 | S187 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O14497 | ARID1A | S304 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14647 | CHD2 | S1792 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14686 | KMT2D | S4328 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14733 | MAP2K7 | S58 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| O14920 | IKBKB | S675 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O60239 | SH3BP5 | S354 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O75147 | OBSL1 | S123 | ochoa | Obscurin-like protein 1 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| O75376 | NCOR1 | S1266 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2105 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75925 | PIAS1 | S488 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O75925 | PIAS1 | S506 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O75962 | TRIO | S2462 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O75962 | TRIO | S2495 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94887 | FARP2 | S402 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95071 | UBR5 | S615 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95359 | TACC2 | S2443 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P01106 | MYC | Y89 | psp | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}. |
| P08651 | NFIC | S473 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08913 | ADRA2A | S314 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
| P10636 | MAPT | S555 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S1598 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11137 | MAP2 | S1611 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11277 | SPTB | S2117 | psp | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P11388 | TOP2A | S1452 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P15822 | HIVEP1 | S2353 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18887 | XRCC1 | S229 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19634 | SLC9A1 | S788 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P22681 | CBL | S486 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23588 | EIF4B | S462 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P23771 | GATA3 | S118 | ochoa | Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}. |
| P27816 | MAP4 | S899 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S915 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28324 | ELK4 | S218 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P42702 | LIFR | S1044 | ochoa|psp | Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. |
| P46531 | NOTCH1 | S2516 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P49815 | TSC2 | S1452 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49848 | TAF6 | S639 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P51587 | BRCA2 | S2098 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P54259 | ATN1 | S358 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P57682 | KLF3 | S111 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P78312 | FAM193A | S740 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78325 | ADAM8 | Y766 | ochoa | Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) | Possible involvement in extravasation of leukocytes. |
| P78559 | MAP1A | S2649 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P81408 | ENTREP3 | S467 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
| P85037 | FOXK1 | S475 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q05209 | PTPN12 | S372 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08495 | DMTN | S90 | ochoa|psp | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q08AD1 | CAMSAP2 | S1304 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09028 | RBBP4 | S147 | ochoa | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}. |
| Q0JRZ9 | FCHO2 | S468 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12948 | FOXC1 | S262 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13112 | CHAF1B | S523 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13541 | EIF4EBP1 | S86 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13625 | TP53BP2 | S561 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14004 | CDK13 | S352 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14202 | ZMYM3 | S54 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14451 | GRB7 | S79 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14676 | MDC1 | S1732 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14980 | NUMA1 | S1760 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15648 | MED1 | S1045 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15772 | SPEG | S560 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16576 | RBBP7 | S146 | ochoa | Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q16799 | RTN1 | S330 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2M1Z3 | ARHGAP31 | S1346 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2TAZ0 | ATG2A | S1312 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q3MIN7 | RGL3 | S558 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q4VCS5 | AMOT | S328 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q504U0 | C4orf46 | S22 | ochoa | Renal cancer differentiation gene 1 protein | None |
| Q53ET0 | CRTC2 | S436 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q53H80 | AKIRIN2 | S42 | ochoa | Akirin-2 | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}. |
| Q58EX2 | SDK2 | S2022 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5HYK7 | SH3D19 | S151 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5JRA6 | MIA3 | S1673 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JSZ5 | PRRC2B | S244 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SYE7 | NHSL1 | S854 | ochoa | NHS-like protein 1 | None |
| Q5T7B8 | KIF24 | S603 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TGY3 | AHDC1 | S1014 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VWG9 | TAF3 | S114 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q5VWG9 | TAF3 | T670 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q5VWQ8 | DAB2IP | S827 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q66K74 | MAP1S | S585 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68EM7 | ARHGAP17 | S561 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6F5E8 | CARMIL2 | S1400 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ22 | RAB12 | S223 | ochoa | Ras-related protein Rab-12 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}. |
| Q6N022 | TENM4 | S199 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6P0N0 | MIS18BP1 | S1027 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P2E9 | EDC4 | S708 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PJF5 | RHBDF2 | S328 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6ZNC4 | ZNF704 | S335 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q6ZRV2 | FAM83H | S516 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZTU2 | EP400P1 | Y109 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q6ZVF9 | GPRIN3 | S619 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q70E73 | RAPH1 | S856 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q70E73 | RAPH1 | S1069 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q70EL1 | USP54 | Y635 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q70EL1 | USP54 | S1061 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L9B9 | EEPD1 | S223 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3K3 | POGZ | S437 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z6I6 | ARHGAP30 | S1037 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86U44 | METTL3 | S67 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86UP3 | ZFHX4 | S2727 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86UU0 | BCL9L | S1054 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S223 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86VR2 | RETREG3 | S436 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86X27 | RALGPS2 | S311 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86X51 | EZHIP | S468 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YW5 | TREML1 | S239 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IWQ3 | BRSK2 | S426 | ochoa | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}. |
| Q8IY81 | FTSJ3 | S576 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8IZD2 | KMT2E | S1362 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8N1G1 | REXO1 | S462 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N350 | CBARP | S399 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3F8 | MICALL1 | S518 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8NBF6 | AVL9 | S326 | ochoa | Late secretory pathway protein AVL9 homolog | Functions in cell migration. {ECO:0000269|PubMed:22595670}. |
| Q8NDX5 | PHC3 | S683 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8WUF5 | PPP1R13L | S113 | ochoa|psp | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WXE0 | CASKIN2 | S711 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WYP5 | AHCTF1 | Y1145 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92793 | CREBBP | S977 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969S8 | HDAC10 | S371 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
| Q96AG3 | SLC25A46 | Y64 | ochoa | Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) | Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}. |
| Q96AP7 | ESAM | S339 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96AV8 | E2F7 | Y843 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96DF8 | ESS2 | S440 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96JM3 | CHAMP1 | S267 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S311 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96L34 | MARK4 | S546 | ochoa | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) | Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}. |
| Q96L91 | EP400 | Y120 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96PD2 | DCBLD2 | S727 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | None |
| Q96PK6 | RBM14 | S294 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96QU8 | XPO6 | S227 | ochoa | Exportin-6 (Exp6) (Ran-binding protein 20) | Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269|PubMed:14592989}. |
| Q96ST3 | SIN3A | S254 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96T37 | RBM15 | S659 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99700 | ATXN2 | S736 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQ70 | TCF25 | S605 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BQQ3 | GORASP1 | S220 | ochoa | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| Q9C0C2 | TNKS1BP1 | S747 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0C5 | BTBD1 | S33 | ochoa | BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8) | Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). {ECO:0000250|UniProtKB:P58544, ECO:0000269|PubMed:14528312}. |
| Q9H211 | CDT1 | S391 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H3S7 | PTPN23 | S1126 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H5H4 | ZNF768 | S107 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H6S3 | EPS8L2 | S452 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H792 | PEAK1 | S864 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9NPG3 | UBN1 | S953 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQC1 | JADE2 | S120 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NQC3 | RTN4 | S114 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NR12 | PDLIM7 | S220 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NRA0 | SPHK2 | S487 | ochoa | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| Q9NYV4 | CDK12 | S1075 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NZJ0 | DTL | S447 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9NZJ0 | DTL | S626 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P206 | NHSL3 | S529 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P206 | NHSL3 | Y982 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P244 | LRFN1 | S682 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P2B4 | CTTNBP2NL | S563 | ochoa|psp | CTTNBP2 N-terminal-like protein | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}. |
| Q9UGJ0 | PRKAG2 | S90 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UGP4 | LIMD1 | S424 | ochoa|psp | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UKI8 | TLK1 | S41 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9ULQ0 | STRIP2 | S321 | ochoa | Striatin-interacting protein 2 (Protein FAM40B) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:21834987). Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987}. |
| Q9ULU4 | ZMYND8 | S655 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMN6 | KMT2B | S1553 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMN6 | KMT2B | S1890 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMN6 | KMT2B | S1893 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPT8 | ZC3H4 | Y162 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S300 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2429 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y283 | INVS | S617 | ochoa | Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:15852005, ECO:0000269|PubMed:18371931}. |
| Q9Y2V2 | CARHSP1 | S26 | ochoa | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y3Q8 | TSC22D4 | S145 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4F5 | CEP170B | S1551 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4I1 | MYO5A | S603 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
| Q9Y572 | RIPK3 | S413 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| Q9Y6D6 | ARFGEF1 | S1558 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6I3 | EPN1 | S420 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.000157 | 3.803 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.000157 | 3.803 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.000157 | 3.803 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.000157 | 3.803 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.000157 | 3.803 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.000061 | 4.218 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.000171 | 3.768 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.000143 | 3.846 |
| R-HSA-212436 | Generic Transcription Pathway | 0.000023 | 4.630 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000057 | 4.244 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.000224 | 3.650 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000343 | 3.465 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.000480 | 3.319 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000649 | 3.188 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000826 | 3.083 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000873 | 3.059 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.001075 | 2.969 |
| R-HSA-1538133 | G0 and Early G1 | 0.001064 | 2.973 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.001100 | 2.958 |
| R-HSA-4839726 | Chromatin organization | 0.001266 | 2.898 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001234 | 2.909 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.001959 | 2.708 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.002128 | 2.672 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.002128 | 2.672 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.002478 | 2.606 |
| R-HSA-165159 | MTOR signalling | 0.002866 | 2.543 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.003083 | 2.511 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.003439 | 2.464 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.004956 | 2.305 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.006150 | 2.211 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.006150 | 2.211 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.006319 | 2.199 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.006438 | 2.191 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.006973 | 2.157 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.008361 | 2.078 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.008701 | 2.060 |
| R-HSA-9707616 | Heme signaling | 0.009225 | 2.035 |
| R-HSA-182971 | EGFR downregulation | 0.009368 | 2.028 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.010162 | 1.993 |
| R-HSA-157118 | Signaling by NOTCH | 0.011277 | 1.948 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.011122 | 1.954 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.011674 | 1.933 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.011674 | 1.933 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.012158 | 1.915 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.012562 | 1.901 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.015050 | 1.822 |
| R-HSA-4641265 | Repression of WNT target genes | 0.015050 | 1.822 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.015050 | 1.822 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.015050 | 1.822 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.015050 | 1.822 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.013986 | 1.854 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.016863 | 1.773 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.016863 | 1.773 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.016863 | 1.773 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.022838 | 1.641 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.022838 | 1.641 |
| R-HSA-774815 | Nucleosome assembly | 0.024104 | 1.618 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.024104 | 1.618 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.020751 | 1.683 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.020751 | 1.683 |
| R-HSA-373756 | SDK interactions | 0.022838 | 1.641 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.022821 | 1.642 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.024104 | 1.618 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.022821 | 1.642 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.018714 | 1.728 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.020400 | 1.690 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.021910 | 1.659 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.034062 | 1.468 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.034062 | 1.468 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.056126 | 1.251 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.056126 | 1.251 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.056126 | 1.251 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.066969 | 1.174 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.066969 | 1.174 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.066969 | 1.174 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.066969 | 1.174 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.066969 | 1.174 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.066969 | 1.174 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.077688 | 1.110 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.077688 | 1.110 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.088285 | 1.054 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.088285 | 1.054 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.088285 | 1.054 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.109117 | 0.962 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.129476 | 0.888 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.042142 | 1.375 |
| R-HSA-429947 | Deadenylation of mRNA | 0.047666 | 1.322 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.159149 | 0.798 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.168814 | 0.773 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.168814 | 0.773 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.168814 | 0.773 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.059441 | 1.226 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.088994 | 1.051 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.044991 | 1.347 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.103264 | 0.986 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.242265 | 0.616 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.242265 | 0.616 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.242265 | 0.616 |
| R-HSA-167161 | HIV Transcription Initiation | 0.110619 | 0.956 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.110619 | 0.956 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.250981 | 0.600 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.250981 | 0.600 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.250981 | 0.600 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.250981 | 0.600 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.250981 | 0.600 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.145772 | 0.836 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.080340 | 1.095 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.080340 | 1.095 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.065665 | 1.183 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.178370 | 0.749 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.080340 | 1.095 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.125717 | 0.901 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.066969 | 1.174 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.129476 | 0.888 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.215510 | 0.667 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.118106 | 0.928 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.127827 | 0.893 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.077688 | 1.110 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.031896 | 1.496 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.110619 | 0.956 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.259596 | 0.586 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.177566 | 0.751 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.072502 | 1.140 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.197154 | 0.705 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.050500 | 1.297 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.066969 | 1.174 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.187816 | 0.726 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.197154 | 0.705 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.159149 | 0.798 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.106924 | 0.971 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.129476 | 0.888 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.206385 | 0.685 |
| R-HSA-9843745 | Adipogenesis | 0.028817 | 1.540 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.056126 | 1.251 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.088285 | 1.054 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.119355 | 0.923 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.139480 | 0.855 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.159149 | 0.798 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.159149 | 0.798 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.187816 | 0.726 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.206385 | 0.685 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.043389 | 1.363 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.233449 | 0.632 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.233449 | 0.632 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.103264 | 0.986 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.206682 | 0.685 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.058073 | 1.236 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.133354 | 0.875 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.109117 | 0.962 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.168814 | 0.773 |
| R-HSA-177929 | Signaling by EGFR | 0.038761 | 1.412 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.119355 | 0.923 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.178370 | 0.749 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.232015 | 0.634 |
| R-HSA-9824272 | Somitogenesis | 0.125717 | 0.901 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.197154 | 0.705 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.250981 | 0.600 |
| R-HSA-9909396 | Circadian clock | 0.093715 | 1.028 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.109117 | 0.962 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.139480 | 0.855 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.139480 | 0.855 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.075384 | 1.123 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.233449 | 0.632 |
| R-HSA-5693538 | Homology Directed Repair | 0.196877 | 0.706 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.046621 | 1.331 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.033347 | 1.477 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.129476 | 0.888 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.042142 | 1.375 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.197154 | 0.705 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.103264 | 0.986 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.103264 | 0.986 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.066969 | 1.174 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.109117 | 0.962 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.159149 | 0.798 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.215510 | 0.667 |
| R-HSA-9710421 | Defective pyroptosis | 0.118106 | 0.928 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.029538 | 1.530 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.051116 | 1.291 |
| R-HSA-9830364 | Formation of the nephric duct | 0.050521 | 1.297 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.187816 | 0.726 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.232015 | 0.634 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.029513 | 1.530 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.197154 | 0.705 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.215510 | 0.667 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.085526 | 1.068 |
| R-HSA-3214847 | HATs acetylate histones | 0.039646 | 1.402 |
| R-HSA-167172 | Transcription of the HIV genome | 0.219317 | 0.659 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.119355 | 0.923 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.119355 | 0.923 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.129476 | 0.888 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.139480 | 0.855 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.168814 | 0.773 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.168814 | 0.773 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.168814 | 0.773 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.187816 | 0.726 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.206385 | 0.685 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.056410 | 1.249 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.106924 | 0.971 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.197154 | 0.705 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.168177 | 0.774 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.149371 | 0.826 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.194132 | 0.712 |
| R-HSA-8939211 | ESR-mediated signaling | 0.178086 | 0.749 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.168177 | 0.774 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.211651 | 0.674 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.154328 | 0.812 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.047666 | 1.322 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.077688 | 1.110 |
| R-HSA-9613354 | Lipophagy | 0.129476 | 0.888 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.149371 | 0.826 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.233449 | 0.632 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.148894 | 0.827 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.240507 | 0.619 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.121897 | 0.914 |
| R-HSA-199991 | Membrane Trafficking | 0.153524 | 0.814 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.143525 | 0.843 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.244759 | 0.611 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.227776 | 0.642 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.088285 | 1.054 |
| R-HSA-390696 | Adrenoceptors | 0.119355 | 0.923 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.040274 | 1.395 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.224531 | 0.649 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.114346 | 0.942 |
| R-HSA-2262752 | Cellular responses to stress | 0.221932 | 0.654 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.048490 | 1.314 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.078004 | 1.108 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.043019 | 1.366 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.037486 | 1.426 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.194132 | 0.712 |
| R-HSA-69206 | G1/S Transition | 0.080340 | 1.095 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.249013 | 0.604 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.139480 | 0.855 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.075384 | 1.123 |
| R-HSA-201556 | Signaling by ALK | 0.099640 | 1.002 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.169370 | 0.771 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.227776 | 0.642 |
| R-HSA-9830369 | Kidney development | 0.057005 | 1.244 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.039646 | 1.402 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.065665 | 1.183 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.103183 | 0.986 |
| R-HSA-2028269 | Signaling by Hippo | 0.224531 | 0.649 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.259596 | 0.586 |
| R-HSA-1640170 | Cell Cycle | 0.081350 | 1.090 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.144000 | 0.842 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.259596 | 0.586 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.259596 | 0.586 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.029538 | 1.530 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.101003 | 0.996 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.109117 | 0.962 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.168814 | 0.773 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.187816 | 0.726 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.206385 | 0.685 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.093915 | 1.027 |
| R-HSA-450294 | MAP kinase activation | 0.189970 | 0.721 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.236259 | 0.627 |
| R-HSA-9758941 | Gastrulation | 0.129316 | 0.888 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.259596 | 0.586 |
| R-HSA-448424 | Interleukin-17 signaling | 0.227776 | 0.642 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.036881 | 1.433 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.168814 | 0.773 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.168814 | 0.773 |
| R-HSA-2559583 | Cellular Senescence | 0.029001 | 1.538 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.072001 | 1.143 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.134380 | 0.872 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.131328 | 0.882 |
| R-HSA-73886 | Chromosome Maintenance | 0.205711 | 0.687 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.129476 | 0.888 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.139480 | 0.855 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.041817 | 1.379 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.076498 | 1.116 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.227776 | 0.642 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.253270 | 0.596 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.086420 | 1.063 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.111437 | 0.953 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.038761 | 1.412 |
| R-HSA-162582 | Signal Transduction | 0.088759 | 1.052 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.048039 | 1.318 |
| R-HSA-73887 | Death Receptor Signaling | 0.139507 | 0.855 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.121897 | 0.914 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.062573 | 1.204 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.185822 | 0.731 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.183210 | 0.737 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.183210 | 0.737 |
| R-HSA-8853659 | RET signaling | 0.088994 | 1.051 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.092503 | 1.034 |
| R-HSA-195721 | Signaling by WNT | 0.164203 | 0.785 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.165297 | 0.782 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.062573 | 1.204 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.098505 | 1.007 |
| R-HSA-4086398 | Ca2+ pathway | 0.240507 | 0.619 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.251805 | 0.599 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.105261 | 0.978 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.075384 | 1.123 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.092503 | 1.034 |
| R-HSA-210993 | Tie2 Signaling | 0.233449 | 0.632 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.185822 | 0.731 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.198304 | 0.703 |
| R-HSA-6807070 | PTEN Regulation | 0.108073 | 0.966 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.037486 | 1.426 |
| R-HSA-421270 | Cell-cell junction organization | 0.095871 | 1.018 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.215993 | 0.666 |
| R-HSA-449147 | Signaling by Interleukins | 0.072869 | 1.137 |
| R-HSA-186797 | Signaling by PDGF | 0.194132 | 0.712 |
| R-HSA-418990 | Adherens junctions interactions | 0.143052 | 0.845 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.137343 | 0.862 |
| R-HSA-446728 | Cell junction organization | 0.132945 | 0.876 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.240507 | 0.619 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.082101 | 1.086 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.224531 | 0.649 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.224531 | 0.649 |
| R-HSA-1500931 | Cell-Cell communication | 0.194760 | 0.710 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.236259 | 0.627 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.118106 | 0.928 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.178370 | 0.749 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.224531 | 0.649 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.244759 | 0.611 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.152146 | 0.818 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.228296 | 0.642 |
| R-HSA-186712 | Regulation of beta-cell development | 0.181687 | 0.741 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.261789 | 0.582 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.261789 | 0.582 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.261789 | 0.582 |
| R-HSA-1266738 | Developmental Biology | 0.262046 | 0.582 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.266050 | 0.575 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.268113 | 0.572 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.268113 | 0.572 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.268113 | 0.572 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.270311 | 0.568 |
| R-HSA-9833482 | PKR-mediated signaling | 0.270311 | 0.568 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.273632 | 0.563 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.276532 | 0.558 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.276532 | 0.558 |
| R-HSA-73894 | DNA Repair | 0.277030 | 0.557 |
| R-HSA-200425 | Carnitine shuttle | 0.284855 | 0.545 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.284855 | 0.545 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.284855 | 0.545 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.285208 | 0.545 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.287343 | 0.542 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.293083 | 0.533 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.293083 | 0.533 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.293083 | 0.533 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.297727 | 0.526 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.300234 | 0.523 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.300863 | 0.522 |
| R-HSA-69242 | S Phase | 0.300863 | 0.522 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.301217 | 0.521 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.301217 | 0.521 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.301217 | 0.521 |
| R-HSA-2160916 | Hyaluronan degradation | 0.301217 | 0.521 |
| R-HSA-8951664 | Neddylation | 0.304071 | 0.517 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.304332 | 0.517 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.309258 | 0.510 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.309258 | 0.510 |
| R-HSA-3295583 | TRP channels | 0.309258 | 0.510 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.309258 | 0.510 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.309258 | 0.510 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.309258 | 0.510 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.316562 | 0.500 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.317029 | 0.499 |
| R-HSA-73884 | Base Excision Repair | 0.317029 | 0.499 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.317206 | 0.499 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.317206 | 0.499 |
| R-HSA-264876 | Insulin processing | 0.317206 | 0.499 |
| R-HSA-1989781 | PPARA activates gene expression | 0.322848 | 0.491 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.325064 | 0.488 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.332831 | 0.478 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.332831 | 0.478 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.332831 | 0.478 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.340510 | 0.468 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.340510 | 0.468 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.340510 | 0.468 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.340510 | 0.468 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.340510 | 0.468 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.342251 | 0.466 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.348101 | 0.458 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.348101 | 0.458 |
| R-HSA-186763 | Downstream signal transduction | 0.348101 | 0.458 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.350596 | 0.455 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.355605 | 0.449 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.355605 | 0.449 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.358905 | 0.445 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.358905 | 0.445 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.358905 | 0.445 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.362572 | 0.441 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.363023 | 0.440 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.363023 | 0.440 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.363023 | 0.440 |
| R-HSA-9930044 | Nuclear RNA decay | 0.363023 | 0.440 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.363023 | 0.440 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.363023 | 0.440 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.363046 | 0.440 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.370356 | 0.431 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.370356 | 0.431 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.370356 | 0.431 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.375406 | 0.425 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.377605 | 0.423 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.377605 | 0.423 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.377605 | 0.423 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.377605 | 0.423 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.377605 | 0.423 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.377605 | 0.423 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.377605 | 0.423 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.377605 | 0.423 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.384771 | 0.415 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.384771 | 0.415 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.386887 | 0.412 |
| R-HSA-9833110 | RSV-host interactions | 0.387668 | 0.412 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.391732 | 0.407 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.391855 | 0.407 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.391855 | 0.407 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.391855 | 0.407 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.391855 | 0.407 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.398858 | 0.399 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.399824 | 0.398 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.399824 | 0.398 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.403851 | 0.394 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.403851 | 0.394 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.405781 | 0.392 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.405781 | 0.392 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.406937 | 0.390 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.407866 | 0.389 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.419389 | 0.377 |
| R-HSA-5260271 | Diseases of Immune System | 0.419389 | 0.377 |
| R-HSA-3371568 | Attenuation phase | 0.419389 | 0.377 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.419389 | 0.377 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.419389 | 0.377 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.423791 | 0.373 |
| R-HSA-9607240 | FLT3 Signaling | 0.426076 | 0.371 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.427739 | 0.369 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.432687 | 0.364 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.435590 | 0.361 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.435590 | 0.361 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.437700 | 0.359 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.439222 | 0.357 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.439222 | 0.357 |
| R-HSA-73928 | Depyrimidination | 0.439222 | 0.357 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.443384 | 0.353 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.443384 | 0.353 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.445682 | 0.351 |
| R-HSA-8854214 | TBC/RABGAPs | 0.445682 | 0.351 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.445682 | 0.351 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.447259 | 0.349 |
| R-HSA-373752 | Netrin-1 signaling | 0.452069 | 0.345 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.452069 | 0.345 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.452069 | 0.345 |
| R-HSA-5683826 | Surfactant metabolism | 0.452069 | 0.345 |
| R-HSA-9609690 | HCMV Early Events | 0.452754 | 0.344 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.454963 | 0.342 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.454963 | 0.342 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.458382 | 0.339 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.458382 | 0.339 |
| R-HSA-68875 | Mitotic Prophase | 0.458792 | 0.338 |
| R-HSA-9675135 | Diseases of DNA repair | 0.464622 | 0.333 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.464622 | 0.333 |
| R-HSA-75153 | Apoptotic execution phase | 0.464622 | 0.333 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.466404 | 0.331 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.466404 | 0.331 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.470599 | 0.327 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.470791 | 0.327 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.476890 | 0.322 |
| R-HSA-425410 | Metal ion SLC transporters | 0.476890 | 0.322 |
| R-HSA-5357801 | Programmed Cell Death | 0.482351 | 0.317 |
| R-HSA-73893 | DNA Damage Bypass | 0.482918 | 0.316 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.488878 | 0.311 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.494769 | 0.306 |
| R-HSA-912446 | Meiotic recombination | 0.494769 | 0.306 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.494769 | 0.306 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.494769 | 0.306 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.500593 | 0.301 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.500593 | 0.301 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.500593 | 0.301 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.500593 | 0.301 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.500593 | 0.301 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.506349 | 0.296 |
| R-HSA-72649 | Translation initiation complex formation | 0.512040 | 0.291 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.512040 | 0.291 |
| R-HSA-418597 | G alpha (z) signalling events | 0.517666 | 0.286 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.523227 | 0.281 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.523227 | 0.281 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.523227 | 0.281 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.523227 | 0.281 |
| R-HSA-75893 | TNF signaling | 0.523227 | 0.281 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.523227 | 0.281 |
| R-HSA-163685 | Integration of energy metabolism | 0.528453 | 0.277 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.528453 | 0.277 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.531949 | 0.274 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.539530 | 0.268 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.544840 | 0.264 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.544840 | 0.264 |
| R-HSA-1632852 | Macroautophagy | 0.545757 | 0.263 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.552555 | 0.258 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.552555 | 0.258 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.555279 | 0.255 |
| R-HSA-373755 | Semaphorin interactions | 0.560408 | 0.251 |
| R-HSA-8848021 | Signaling by PTK6 | 0.560408 | 0.251 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.560408 | 0.251 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.565479 | 0.248 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.579027 | 0.237 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.580345 | 0.236 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.580345 | 0.236 |
| R-HSA-5218859 | Regulated Necrosis | 0.585187 | 0.233 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.585187 | 0.233 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.591829 | 0.228 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.594705 | 0.226 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.594705 | 0.226 |
| R-HSA-9612973 | Autophagy | 0.598121 | 0.223 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.599382 | 0.222 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.599382 | 0.222 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.601010 | 0.221 |
| R-HSA-162587 | HIV Life Cycle | 0.601240 | 0.221 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.604005 | 0.219 |
| R-HSA-9609646 | HCMV Infection | 0.604900 | 0.218 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.608576 | 0.216 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.613094 | 0.212 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.613094 | 0.212 |
| R-HSA-109581 | Apoptosis | 0.616562 | 0.210 |
| R-HSA-5688426 | Deubiquitination | 0.617289 | 0.210 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.617560 | 0.209 |
| R-HSA-5689603 | UCH proteinases | 0.621974 | 0.206 |
| R-HSA-9659379 | Sensory processing of sound | 0.634917 | 0.197 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.639132 | 0.194 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.639132 | 0.194 |
| R-HSA-6806834 | Signaling by MET | 0.639132 | 0.194 |
| R-HSA-422475 | Axon guidance | 0.640383 | 0.194 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.643299 | 0.192 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.645850 | 0.190 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.651492 | 0.186 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.655516 | 0.183 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.657063 | 0.182 |
| R-HSA-1500620 | Meiosis | 0.659494 | 0.181 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.659494 | 0.181 |
| R-HSA-8953854 | Metabolism of RNA | 0.660311 | 0.180 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.663428 | 0.178 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.663428 | 0.178 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.663428 | 0.178 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.663428 | 0.178 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.667315 | 0.176 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.674958 | 0.171 |
| R-HSA-9663891 | Selective autophagy | 0.674958 | 0.171 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.678713 | 0.168 |
| R-HSA-202424 | Downstream TCR signaling | 0.682426 | 0.166 |
| R-HSA-69275 | G2/M Transition | 0.686443 | 0.163 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.691559 | 0.160 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.693308 | 0.159 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.694481 | 0.158 |
| R-HSA-5617833 | Cilium Assembly | 0.696606 | 0.157 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.696853 | 0.157 |
| R-HSA-9675108 | Nervous system development | 0.699646 | 0.155 |
| R-HSA-68877 | Mitotic Prometaphase | 0.704049 | 0.152 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.707244 | 0.150 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.708838 | 0.149 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.710628 | 0.148 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.717281 | 0.144 |
| R-HSA-190236 | Signaling by FGFR | 0.717281 | 0.144 |
| R-HSA-422356 | Regulation of insulin secretion | 0.717281 | 0.144 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.723781 | 0.140 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.726975 | 0.138 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.727774 | 0.138 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.736339 | 0.133 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.745383 | 0.128 |
| R-HSA-69239 | Synthesis of DNA | 0.748328 | 0.126 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.749878 | 0.125 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.751240 | 0.124 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.751240 | 0.124 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.751240 | 0.124 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.751240 | 0.124 |
| R-HSA-597592 | Post-translational protein modification | 0.751845 | 0.124 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.754118 | 0.123 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.754118 | 0.123 |
| R-HSA-202403 | TCR signaling | 0.756964 | 0.121 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.762556 | 0.118 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.768020 | 0.115 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.770705 | 0.113 |
| R-HSA-373760 | L1CAM interactions | 0.778576 | 0.109 |
| R-HSA-162906 | HIV Infection | 0.780146 | 0.108 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.781140 | 0.107 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.782046 | 0.107 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.783674 | 0.106 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.786179 | 0.104 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.791102 | 0.102 |
| R-HSA-3371556 | Cellular response to heat stress | 0.791102 | 0.102 |
| R-HSA-9679506 | SARS-CoV Infections | 0.798028 | 0.098 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.798508 | 0.098 |
| R-HSA-69481 | G2/M Checkpoints | 0.807463 | 0.093 |
| R-HSA-1474165 | Reproduction | 0.816233 | 0.088 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.820468 | 0.086 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.832721 | 0.080 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.834539 | 0.079 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.838354 | 0.077 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.838354 | 0.077 |
| R-HSA-9664407 | Parasite infection | 0.838354 | 0.077 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.840059 | 0.076 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.840229 | 0.076 |
| R-HSA-416476 | G alpha (q) signalling events | 0.841491 | 0.075 |
| R-HSA-68886 | M Phase | 0.846561 | 0.072 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.847514 | 0.072 |
| R-HSA-913531 | Interferon Signaling | 0.847748 | 0.072 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.861630 | 0.065 |
| R-HSA-69306 | DNA Replication | 0.862719 | 0.064 |
| R-HSA-9658195 | Leishmania infection | 0.864131 | 0.063 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.864131 | 0.063 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.870504 | 0.060 |
| R-HSA-877300 | Interferon gamma signaling | 0.872007 | 0.059 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.879269 | 0.056 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.888241 | 0.051 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.888751 | 0.051 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.892584 | 0.049 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.892584 | 0.049 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.893833 | 0.049 |
| R-HSA-72766 | Translation | 0.894403 | 0.048 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.895067 | 0.048 |
| R-HSA-3781865 | Diseases of glycosylation | 0.905550 | 0.043 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.907972 | 0.042 |
| R-HSA-8957322 | Metabolism of steroids | 0.908835 | 0.042 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.909868 | 0.041 |
| R-HSA-983712 | Ion channel transport | 0.910917 | 0.041 |
| R-HSA-392499 | Metabolism of proteins | 0.914387 | 0.039 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.914991 | 0.039 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.915980 | 0.038 |
| R-HSA-9824446 | Viral Infection Pathways | 0.919397 | 0.036 |
| R-HSA-428157 | Sphingolipid metabolism | 0.922592 | 0.035 |
| R-HSA-112316 | Neuronal System | 0.923489 | 0.035 |
| R-HSA-72172 | mRNA Splicing | 0.926134 | 0.033 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.928095 | 0.032 |
| R-HSA-1280218 | Adaptive Immune System | 0.930510 | 0.031 |
| R-HSA-68882 | Mitotic Anaphase | 0.935824 | 0.029 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.936572 | 0.028 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.944899 | 0.025 |
| R-HSA-72312 | rRNA processing | 0.946804 | 0.024 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.948720 | 0.023 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.952108 | 0.021 |
| R-HSA-109582 | Hemostasis | 0.958066 | 0.019 |
| R-HSA-168256 | Immune System | 0.959362 | 0.018 |
| R-HSA-5663205 | Infectious disease | 0.964728 | 0.016 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.967525 | 0.014 |
| R-HSA-1643685 | Disease | 0.969535 | 0.013 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.970443 | 0.013 |
| R-HSA-6798695 | Neutrophil degranulation | 0.975380 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 0.983413 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.992221 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.992493 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 0.993333 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.993333 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.994742 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.995360 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.996047 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.996231 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.997961 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999240 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999424 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999688 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CK1E |
0.777 | 0.442 | -3 | 0.750 |
CK1D |
0.774 | 0.419 | -3 | 0.761 |
CK1A2 |
0.767 | 0.412 | -3 | 0.764 |
KIS |
0.767 | 0.189 | 1 | 0.755 |
CDKL5 |
0.765 | 0.302 | -3 | 0.273 |
HIPK4 |
0.762 | 0.286 | 1 | 0.832 |
MAK |
0.759 | 0.398 | -2 | 0.816 |
CK1G1 |
0.756 | 0.358 | -3 | 0.723 |
HIPK2 |
0.752 | 0.212 | 1 | 0.708 |
CLK3 |
0.752 | 0.164 | 1 | 0.831 |
COT |
0.751 | 0.113 | 2 | 0.901 |
CDKL1 |
0.750 | 0.204 | -3 | 0.288 |
GRK1 |
0.749 | 0.197 | -2 | 0.387 |
P38B |
0.749 | 0.293 | 1 | 0.733 |
ICK |
0.749 | 0.323 | -3 | 0.299 |
ERK5 |
0.748 | 0.202 | 1 | 0.892 |
CK1A |
0.748 | 0.355 | -3 | 0.764 |
CDK19 |
0.745 | 0.236 | 1 | 0.687 |
MOS |
0.745 | 0.181 | 1 | 0.832 |
DYRK2 |
0.744 | 0.169 | 1 | 0.785 |
ERK1 |
0.743 | 0.252 | 1 | 0.719 |
CDK8 |
0.743 | 0.219 | 1 | 0.716 |
P38A |
0.743 | 0.291 | 1 | 0.788 |
CDK18 |
0.742 | 0.203 | 1 | 0.681 |
SRPK1 |
0.741 | 0.045 | -3 | 0.279 |
PIM3 |
0.739 | 0.037 | -3 | 0.316 |
CDC7 |
0.739 | 0.111 | 1 | 0.794 |
HIPK1 |
0.737 | 0.145 | 1 | 0.794 |
MTOR |
0.736 | 0.085 | 1 | 0.770 |
NLK |
0.736 | 0.100 | 1 | 0.842 |
P38D |
0.735 | 0.201 | 1 | 0.656 |
CDK7 |
0.733 | 0.166 | 1 | 0.733 |
IKKB |
0.733 | -0.023 | -2 | 0.308 |
DYRK1A |
0.733 | 0.183 | 1 | 0.782 |
NDR2 |
0.732 | 0.035 | -3 | 0.305 |
CDK1 |
0.732 | 0.162 | 1 | 0.697 |
PRPK |
0.731 | 0.027 | -1 | 0.761 |
ATR |
0.731 | 0.078 | 1 | 0.806 |
GRK5 |
0.730 | 0.105 | -3 | 0.437 |
MLK1 |
0.730 | 0.140 | 2 | 0.883 |
CHAK2 |
0.729 | 0.098 | -1 | 0.690 |
MOK |
0.729 | 0.276 | 1 | 0.846 |
SKMLCK |
0.728 | 0.030 | -2 | 0.404 |
AURC |
0.727 | -0.011 | -2 | 0.275 |
HIPK3 |
0.727 | 0.127 | 1 | 0.789 |
MLK3 |
0.727 | 0.150 | 2 | 0.833 |
SRPK2 |
0.727 | 0.012 | -3 | 0.245 |
P38G |
0.727 | 0.161 | 1 | 0.627 |
DYRK4 |
0.726 | 0.135 | 1 | 0.712 |
CDK17 |
0.726 | 0.154 | 1 | 0.627 |
GRK7 |
0.726 | 0.132 | 1 | 0.715 |
TBK1 |
0.726 | 0.064 | 1 | 0.683 |
PIM1 |
0.726 | 0.006 | -3 | 0.313 |
JNK2 |
0.725 | 0.144 | 1 | 0.686 |
CDK5 |
0.725 | 0.149 | 1 | 0.749 |
RAF1 |
0.725 | -0.016 | 1 | 0.786 |
RIPK3 |
0.725 | 0.072 | 3 | 0.683 |
SRPK3 |
0.724 | 0.007 | -3 | 0.286 |
MLK2 |
0.724 | 0.138 | 2 | 0.876 |
BMPR1B |
0.724 | 0.070 | 1 | 0.745 |
MPSK1 |
0.723 | 0.295 | 1 | 0.788 |
PRKD1 |
0.723 | -0.019 | -3 | 0.254 |
IKKE |
0.722 | -0.008 | 1 | 0.680 |
RSK2 |
0.722 | -0.045 | -3 | 0.254 |
CLK2 |
0.721 | 0.041 | -3 | 0.277 |
BMPR2 |
0.721 | -0.053 | -2 | 0.386 |
WNK1 |
0.720 | -0.006 | -2 | 0.438 |
IKKA |
0.720 | -0.008 | -2 | 0.327 |
PDHK4 |
0.720 | -0.118 | 1 | 0.809 |
CDK16 |
0.720 | 0.163 | 1 | 0.643 |
JNK3 |
0.719 | 0.118 | 1 | 0.715 |
DSTYK |
0.719 | -0.105 | 2 | 0.934 |
MST4 |
0.719 | -0.016 | 2 | 0.924 |
CAMK1B |
0.719 | -0.081 | -3 | 0.309 |
CDK13 |
0.719 | 0.085 | 1 | 0.712 |
PRKD2 |
0.719 | -0.043 | -3 | 0.234 |
CDK14 |
0.719 | 0.131 | 1 | 0.714 |
DYRK3 |
0.718 | 0.074 | 1 | 0.800 |
NDR1 |
0.718 | -0.055 | -3 | 0.287 |
GCN2 |
0.718 | -0.102 | 2 | 0.833 |
PKACB |
0.718 | -0.033 | -2 | 0.260 |
DYRK1B |
0.717 | 0.097 | 1 | 0.734 |
GRK4 |
0.717 | 0.056 | -2 | 0.363 |
CLK4 |
0.717 | -0.005 | -3 | 0.289 |
ERK2 |
0.717 | 0.148 | 1 | 0.746 |
CAMLCK |
0.717 | -0.045 | -2 | 0.375 |
NUAK2 |
0.717 | -0.056 | -3 | 0.311 |
P90RSK |
0.717 | -0.050 | -3 | 0.252 |
CDK10 |
0.716 | 0.112 | 1 | 0.704 |
GRK3 |
0.716 | 0.096 | -2 | 0.296 |
PRP4 |
0.716 | 0.054 | -3 | 0.268 |
NIK |
0.716 | -0.067 | -3 | 0.315 |
GRK6 |
0.716 | 0.067 | 1 | 0.766 |
CDK3 |
0.715 | 0.121 | 1 | 0.648 |
PKN2 |
0.715 | -0.054 | -3 | 0.308 |
MLK4 |
0.715 | 0.130 | 2 | 0.805 |
PKACG |
0.715 | -0.056 | -2 | 0.303 |
PKN3 |
0.715 | -0.059 | -3 | 0.279 |
GRK2 |
0.715 | 0.060 | -2 | 0.320 |
TGFBR2 |
0.715 | -0.087 | -2 | 0.308 |
DAPK2 |
0.714 | -0.055 | -3 | 0.303 |
CK1G3 |
0.714 | 0.312 | -3 | 0.757 |
NEK6 |
0.714 | -0.087 | -2 | 0.345 |
PRKX |
0.713 | -0.032 | -3 | 0.253 |
CAMK2G |
0.713 | -0.082 | 2 | 0.804 |
CDK12 |
0.713 | 0.081 | 1 | 0.688 |
MAPKAPK2 |
0.713 | -0.045 | -3 | 0.235 |
DLK |
0.712 | 0.060 | 1 | 0.765 |
MASTL |
0.712 | -0.090 | -2 | 0.379 |
PDHK1 |
0.712 | -0.161 | 1 | 0.791 |
IRE1 |
0.712 | 0.033 | 1 | 0.780 |
MAPKAPK3 |
0.712 | -0.075 | -3 | 0.237 |
CLK1 |
0.712 | -0.012 | -3 | 0.251 |
ULK2 |
0.712 | -0.155 | 2 | 0.815 |
RSK4 |
0.711 | -0.016 | -3 | 0.256 |
RSK3 |
0.711 | -0.070 | -3 | 0.237 |
PKCD |
0.711 | -0.025 | 2 | 0.858 |
P70S6KB |
0.710 | -0.068 | -3 | 0.267 |
MARK4 |
0.710 | -0.077 | 4 | 0.817 |
PAK1 |
0.710 | -0.031 | -2 | 0.390 |
PKCB |
0.709 | -0.005 | 2 | 0.829 |
AMPKA1 |
0.708 | -0.067 | -3 | 0.301 |
FAM20C |
0.708 | 0.033 | 2 | 0.620 |
BCKDK |
0.708 | -0.091 | -1 | 0.664 |
NEK7 |
0.708 | -0.152 | -3 | 0.310 |
AKT2 |
0.708 | -0.045 | -3 | 0.246 |
PKCA |
0.708 | 0.017 | 2 | 0.820 |
PKG2 |
0.708 | -0.056 | -2 | 0.273 |
TTBK2 |
0.707 | -0.013 | 2 | 0.734 |
ACVR2B |
0.707 | 0.004 | -2 | 0.304 |
AURB |
0.707 | -0.051 | -2 | 0.265 |
PIM2 |
0.707 | -0.030 | -3 | 0.250 |
PKCG |
0.707 | 0.002 | 2 | 0.823 |
NEK9 |
0.707 | -0.095 | 2 | 0.886 |
CAMK2D |
0.706 | -0.102 | -3 | 0.271 |
YSK4 |
0.706 | -0.018 | 1 | 0.722 |
CDK9 |
0.706 | 0.045 | 1 | 0.721 |
RIPK1 |
0.706 | -0.058 | 1 | 0.776 |
MYLK4 |
0.706 | -0.052 | -2 | 0.311 |
ACVR2A |
0.706 | 0.002 | -2 | 0.300 |
LATS1 |
0.706 | -0.011 | -3 | 0.282 |
PRKD3 |
0.705 | -0.064 | -3 | 0.239 |
PKCZ |
0.705 | -0.002 | 2 | 0.852 |
AMPKA2 |
0.705 | -0.060 | -3 | 0.279 |
SMG1 |
0.705 | -0.011 | 1 | 0.770 |
ANKRD3 |
0.705 | -0.098 | 1 | 0.807 |
ALK4 |
0.705 | -0.034 | -2 | 0.344 |
CK1G2 |
0.705 | 0.267 | -3 | 0.742 |
TGFBR1 |
0.704 | -0.038 | -2 | 0.325 |
PAK3 |
0.704 | -0.066 | -2 | 0.362 |
MST3 |
0.704 | 0.069 | 2 | 0.917 |
ERK7 |
0.704 | 0.110 | 2 | 0.667 |
WNK3 |
0.704 | -0.106 | 1 | 0.766 |
PKR |
0.704 | 0.010 | 1 | 0.813 |
LATS2 |
0.704 | -0.071 | -5 | 0.678 |
VRK2 |
0.703 | -0.004 | 1 | 0.841 |
MSK2 |
0.703 | -0.080 | -3 | 0.277 |
MNK2 |
0.703 | -0.066 | -2 | 0.334 |
MEK1 |
0.702 | -0.015 | 2 | 0.861 |
ATM |
0.702 | -0.020 | 1 | 0.743 |
PHKG1 |
0.702 | -0.050 | -3 | 0.294 |
MSK1 |
0.702 | -0.062 | -3 | 0.260 |
ULK1 |
0.701 | -0.161 | -3 | 0.278 |
GSK3A |
0.701 | 0.094 | 4 | 0.553 |
BMPR1A |
0.701 | 0.022 | 1 | 0.712 |
QSK |
0.701 | -0.067 | 4 | 0.790 |
TSSK2 |
0.700 | -0.079 | -5 | 0.809 |
SGK3 |
0.700 | -0.060 | -3 | 0.257 |
JNK1 |
0.700 | 0.102 | 1 | 0.669 |
CAMK2A |
0.700 | -0.048 | 2 | 0.798 |
IRE2 |
0.700 | -0.006 | 2 | 0.796 |
PKACA |
0.700 | -0.061 | -2 | 0.230 |
TSSK1 |
0.700 | -0.063 | -3 | 0.296 |
AURA |
0.700 | -0.051 | -2 | 0.248 |
PAK6 |
0.700 | -0.061 | -2 | 0.306 |
MEKK3 |
0.700 | 0.039 | 1 | 0.759 |
MNK1 |
0.699 | -0.067 | -2 | 0.334 |
PAK2 |
0.699 | -0.059 | -2 | 0.373 |
ALK2 |
0.698 | -0.039 | -2 | 0.324 |
CDK2 |
0.698 | 0.028 | 1 | 0.752 |
MEKK2 |
0.698 | 0.048 | 2 | 0.847 |
HUNK |
0.697 | -0.182 | 2 | 0.821 |
PASK |
0.697 | 0.050 | -3 | 0.341 |
CAMK2B |
0.697 | -0.066 | 2 | 0.775 |
NIM1 |
0.697 | -0.122 | 3 | 0.701 |
CHAK1 |
0.697 | -0.036 | 2 | 0.821 |
QIK |
0.697 | -0.127 | -3 | 0.290 |
CAMK4 |
0.697 | -0.132 | -3 | 0.298 |
SIK |
0.697 | -0.091 | -3 | 0.263 |
TLK2 |
0.697 | -0.032 | 1 | 0.750 |
MELK |
0.696 | -0.115 | -3 | 0.251 |
PKCH |
0.695 | -0.054 | 2 | 0.802 |
CDK6 |
0.695 | 0.093 | 1 | 0.698 |
DNAPK |
0.695 | -0.016 | 1 | 0.696 |
GSK3B |
0.695 | 0.052 | 4 | 0.548 |
TAO3 |
0.694 | 0.030 | 1 | 0.750 |
MEK5 |
0.693 | -0.042 | 2 | 0.860 |
NUAK1 |
0.693 | -0.107 | -3 | 0.250 |
BUB1 |
0.692 | 0.063 | -5 | 0.785 |
AKT1 |
0.692 | -0.064 | -3 | 0.243 |
CDK4 |
0.691 | 0.095 | 1 | 0.677 |
NEK2 |
0.691 | -0.128 | 2 | 0.874 |
AKT3 |
0.691 | -0.046 | -3 | 0.225 |
PLK1 |
0.691 | -0.129 | -2 | 0.303 |
GAK |
0.691 | 0.061 | 1 | 0.832 |
PERK |
0.691 | -0.091 | -2 | 0.334 |
MARK3 |
0.690 | -0.074 | 4 | 0.747 |
DRAK1 |
0.690 | -0.064 | 1 | 0.701 |
NEK5 |
0.689 | -0.065 | 1 | 0.797 |
PKCE |
0.689 | -0.022 | 2 | 0.815 |
BRSK1 |
0.689 | -0.093 | -3 | 0.259 |
CAMK1G |
0.688 | -0.094 | -3 | 0.263 |
MEKK1 |
0.688 | -0.068 | 1 | 0.756 |
BRSK2 |
0.688 | -0.096 | -3 | 0.262 |
ZAK |
0.687 | -0.058 | 1 | 0.712 |
WNK4 |
0.687 | -0.054 | -2 | 0.448 |
SGK1 |
0.687 | -0.048 | -3 | 0.216 |
IRAK4 |
0.687 | -0.046 | 1 | 0.778 |
GCK |
0.687 | 0.044 | 1 | 0.755 |
MAPKAPK5 |
0.687 | -0.139 | -3 | 0.226 |
TLK1 |
0.687 | -0.053 | -2 | 0.327 |
PINK1 |
0.686 | -0.149 | 1 | 0.822 |
PKCI |
0.686 | -0.059 | 2 | 0.832 |
P70S6K |
0.685 | -0.090 | -3 | 0.222 |
DAPK3 |
0.685 | -0.061 | -3 | 0.294 |
PKCT |
0.685 | -0.072 | 2 | 0.807 |
NEK11 |
0.684 | -0.013 | 1 | 0.734 |
DCAMKL1 |
0.684 | -0.111 | -3 | 0.264 |
SMMLCK |
0.684 | -0.099 | -3 | 0.281 |
HPK1 |
0.684 | 0.008 | 1 | 0.748 |
LKB1 |
0.684 | -0.051 | -3 | 0.275 |
MARK2 |
0.683 | -0.102 | 4 | 0.712 |
PAK5 |
0.683 | -0.078 | -2 | 0.296 |
EEF2K |
0.683 | 0.054 | 3 | 0.737 |
MST2 |
0.683 | -0.028 | 1 | 0.762 |
CK2A2 |
0.682 | 0.016 | 1 | 0.672 |
ROCK2 |
0.682 | -0.029 | -3 | 0.275 |
HRI |
0.681 | -0.152 | -2 | 0.346 |
PDHK3_TYR |
0.681 | 0.167 | 4 | 0.891 |
SSTK |
0.681 | -0.080 | 4 | 0.783 |
CHK1 |
0.681 | -0.143 | -3 | 0.223 |
SLK |
0.680 | -0.021 | -2 | 0.324 |
MAP3K15 |
0.680 | 0.044 | 1 | 0.708 |
TNIK |
0.680 | -0.003 | 3 | 0.812 |
TAO2 |
0.680 | -0.054 | 2 | 0.899 |
DAPK1 |
0.680 | -0.062 | -3 | 0.306 |
PAK4 |
0.680 | -0.066 | -2 | 0.301 |
MRCKB |
0.680 | -0.062 | -3 | 0.248 |
PHKG2 |
0.680 | -0.100 | -3 | 0.267 |
YANK3 |
0.679 | 0.090 | 2 | 0.411 |
MEKK6 |
0.679 | -0.026 | 1 | 0.765 |
CAMKK1 |
0.679 | -0.150 | -2 | 0.305 |
TAK1 |
0.679 | -0.009 | 1 | 0.750 |
CAMKK2 |
0.679 | -0.121 | -2 | 0.317 |
MINK |
0.679 | -0.013 | 1 | 0.750 |
PBK |
0.679 | 0.018 | 1 | 0.786 |
SNRK |
0.679 | -0.177 | 2 | 0.686 |
BRAF |
0.679 | -0.150 | -4 | 0.766 |
PLK3 |
0.679 | -0.129 | 2 | 0.765 |
MARK1 |
0.679 | -0.124 | 4 | 0.764 |
HGK |
0.678 | -0.029 | 3 | 0.803 |
KHS1 |
0.678 | 0.027 | 1 | 0.747 |
PDK1 |
0.678 | -0.067 | 1 | 0.744 |
KHS2 |
0.678 | 0.024 | 1 | 0.755 |
CAMK1D |
0.677 | -0.099 | -3 | 0.219 |
PLK4 |
0.677 | -0.113 | 2 | 0.623 |
CK2A1 |
0.677 | 0.028 | 1 | 0.652 |
MAP2K6_TYR |
0.677 | 0.140 | -1 | 0.785 |
PDHK1_TYR |
0.677 | 0.198 | -1 | 0.809 |
ABL2 |
0.677 | 0.155 | -1 | 0.727 |
TTBK1 |
0.677 | -0.073 | 2 | 0.638 |
MAP2K4_TYR |
0.677 | 0.102 | -1 | 0.777 |
NEK8 |
0.677 | -0.096 | 2 | 0.869 |
SBK |
0.677 | -0.059 | -3 | 0.183 |
PDHK4_TYR |
0.677 | 0.145 | 2 | 0.894 |
CHK2 |
0.676 | -0.082 | -3 | 0.214 |
PKN1 |
0.676 | -0.081 | -3 | 0.231 |
LRRK2 |
0.675 | -0.057 | 2 | 0.888 |
LOK |
0.674 | -0.063 | -2 | 0.323 |
ABL1 |
0.674 | 0.149 | -1 | 0.720 |
DMPK1 |
0.674 | -0.042 | -3 | 0.272 |
LCK |
0.673 | 0.131 | -1 | 0.833 |
NEK4 |
0.673 | -0.105 | 1 | 0.759 |
TXK |
0.673 | 0.148 | 1 | 0.786 |
BMPR2_TYR |
0.673 | 0.053 | -1 | 0.819 |
TESK1_TYR |
0.673 | 0.037 | 3 | 0.813 |
MRCKA |
0.673 | -0.074 | -3 | 0.249 |
VRK1 |
0.672 | -0.018 | 2 | 0.858 |
EPHB4 |
0.672 | 0.130 | -1 | 0.750 |
PKMYT1_TYR |
0.672 | 0.007 | 3 | 0.790 |
CAMK1A |
0.672 | -0.083 | -3 | 0.215 |
FGR |
0.671 | 0.095 | 1 | 0.825 |
BLK |
0.671 | 0.123 | -1 | 0.832 |
EPHA6 |
0.670 | 0.076 | -1 | 0.800 |
NEK1 |
0.669 | -0.103 | 1 | 0.766 |
OSR1 |
0.669 | 0.011 | 2 | 0.855 |
DCAMKL2 |
0.669 | -0.131 | -3 | 0.258 |
LIMK2_TYR |
0.668 | 0.023 | -3 | 0.280 |
MAP2K7_TYR |
0.668 | -0.023 | 2 | 0.872 |
MST1 |
0.668 | -0.063 | 1 | 0.747 |
HASPIN |
0.667 | 0.020 | -1 | 0.548 |
TTK |
0.667 | 0.004 | -2 | 0.329 |
PLK2 |
0.667 | -0.062 | -3 | 0.293 |
FYN |
0.667 | 0.129 | -1 | 0.844 |
ROCK1 |
0.667 | -0.059 | -3 | 0.254 |
PKG1 |
0.665 | -0.103 | -2 | 0.217 |
HCK |
0.665 | 0.065 | -1 | 0.816 |
YSK1 |
0.665 | -0.063 | 2 | 0.878 |
CRIK |
0.664 | -0.052 | -3 | 0.236 |
CSF1R |
0.664 | 0.096 | 3 | 0.760 |
PINK1_TYR |
0.663 | -0.068 | 1 | 0.796 |
IRAK1 |
0.663 | -0.208 | -1 | 0.625 |
RET |
0.663 | 0.021 | 1 | 0.762 |
YES1 |
0.663 | 0.050 | -1 | 0.795 |
TNK2 |
0.662 | 0.080 | 3 | 0.742 |
JAK2 |
0.661 | 0.016 | 1 | 0.752 |
MET |
0.661 | 0.111 | 3 | 0.769 |
ALPHAK3 |
0.661 | 0.061 | -1 | 0.682 |
MST1R |
0.661 | 0.020 | 3 | 0.783 |
STK33 |
0.660 | -0.103 | 2 | 0.635 |
ROS1 |
0.659 | 0.010 | 3 | 0.726 |
MYO3B |
0.659 | -0.035 | 2 | 0.891 |
TYRO3 |
0.658 | -0.010 | 3 | 0.756 |
BMX |
0.657 | 0.052 | -1 | 0.686 |
SYK |
0.657 | 0.121 | -1 | 0.782 |
SRMS |
0.657 | 0.028 | 1 | 0.793 |
TYK2 |
0.657 | -0.068 | 1 | 0.757 |
LIMK1_TYR |
0.657 | -0.092 | 2 | 0.877 |
KIT |
0.657 | 0.056 | 3 | 0.756 |
YANK2 |
0.656 | 0.099 | 2 | 0.429 |
JAK3 |
0.656 | 0.008 | 1 | 0.733 |
MEK2 |
0.656 | -0.199 | 2 | 0.830 |
EPHA4 |
0.656 | 0.030 | 2 | 0.771 |
ITK |
0.656 | 0.034 | -1 | 0.749 |
KDR |
0.656 | 0.030 | 3 | 0.721 |
PTK2 |
0.655 | 0.113 | -1 | 0.806 |
FER |
0.655 | -0.009 | 1 | 0.817 |
EPHB3 |
0.655 | 0.037 | -1 | 0.740 |
MYO3A |
0.654 | -0.047 | 1 | 0.751 |
EPHB2 |
0.654 | 0.042 | -1 | 0.744 |
EPHB1 |
0.654 | 0.023 | 1 | 0.792 |
JAK1 |
0.653 | 0.004 | 1 | 0.698 |
INSRR |
0.653 | 0.005 | 3 | 0.684 |
RIPK2 |
0.652 | -0.204 | 1 | 0.675 |
FLT1 |
0.652 | 0.057 | -1 | 0.766 |
ZAP70 |
0.652 | 0.123 | -1 | 0.688 |
LYN |
0.652 | 0.035 | 3 | 0.672 |
ASK1 |
0.651 | -0.048 | 1 | 0.689 |
BIKE |
0.651 | -0.018 | 1 | 0.741 |
TNNI3K_TYR |
0.651 | -0.015 | 1 | 0.788 |
SRC |
0.651 | 0.052 | -1 | 0.808 |
NEK3 |
0.650 | -0.178 | 1 | 0.725 |
FRK |
0.649 | 0.038 | -1 | 0.808 |
MERTK |
0.649 | 0.017 | 3 | 0.741 |
TAO1 |
0.649 | -0.069 | 1 | 0.681 |
DDR1 |
0.649 | -0.086 | 4 | 0.808 |
FLT3 |
0.647 | -0.031 | 3 | 0.758 |
EPHA7 |
0.647 | 0.028 | 2 | 0.776 |
TEC |
0.646 | -0.021 | -1 | 0.673 |
TNK1 |
0.646 | -0.027 | 3 | 0.742 |
BTK |
0.646 | -0.048 | -1 | 0.699 |
MATK |
0.645 | 0.011 | -1 | 0.636 |
WEE1_TYR |
0.644 | -0.029 | -1 | 0.634 |
FGFR2 |
0.644 | -0.046 | 3 | 0.729 |
EPHA1 |
0.643 | 0.006 | 3 | 0.757 |
PTK2B |
0.643 | 0.015 | -1 | 0.704 |
EPHA3 |
0.643 | -0.016 | 2 | 0.742 |
PDGFRB |
0.642 | -0.082 | 3 | 0.764 |
DDR2 |
0.642 | 0.010 | 3 | 0.675 |
ERBB2 |
0.642 | -0.024 | 1 | 0.695 |
EPHA8 |
0.642 | 0.025 | -1 | 0.761 |
NEK10_TYR |
0.641 | -0.074 | 1 | 0.639 |
AXL |
0.641 | -0.051 | 3 | 0.741 |
ALK |
0.640 | -0.053 | 3 | 0.671 |
LTK |
0.639 | -0.054 | 3 | 0.694 |
CSK |
0.639 | 0.036 | 2 | 0.773 |
TEK |
0.639 | -0.097 | 3 | 0.684 |
FGFR3 |
0.638 | -0.032 | 3 | 0.702 |
EPHA5 |
0.638 | 0.002 | 2 | 0.752 |
AAK1 |
0.638 | 0.003 | 1 | 0.663 |
FGFR1 |
0.637 | -0.089 | 3 | 0.717 |
ERBB4 |
0.637 | 0.060 | 1 | 0.623 |
STLK3 |
0.637 | -0.104 | 1 | 0.687 |
PDGFRA |
0.637 | -0.085 | 3 | 0.762 |
NTRK3 |
0.636 | -0.045 | -1 | 0.675 |
PTK6 |
0.636 | -0.095 | -1 | 0.642 |
INSR |
0.636 | -0.039 | 3 | 0.673 |
NTRK1 |
0.635 | -0.095 | -1 | 0.713 |
FGFR4 |
0.635 | 0.002 | -1 | 0.685 |
EGFR |
0.634 | -0.012 | 1 | 0.599 |
EPHA2 |
0.630 | 0.001 | -1 | 0.729 |
NTRK2 |
0.629 | -0.121 | 3 | 0.707 |
FLT4 |
0.629 | -0.089 | 3 | 0.690 |
IGF1R |
0.622 | -0.045 | 3 | 0.606 |
FES |
0.618 | -0.022 | -1 | 0.651 |
MUSK |
0.617 | -0.095 | 1 | 0.612 |