Motif 272 (n=179)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0C4DFX4 None S2613 ochoa Snf2 related CREBBP activator protein None
A6NKD9 CCDC85C S216 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
A6NNA2 SRRM3 S333 ochoa Serine/arginine repetitive matrix protein 3 May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}.
O00273 DFFA S308 ochoa DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Inhibitor of the caspase-activated DNase (DFF40).
O00571 DDX3X S31 ochoa ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.
O14686 KMT2D S4328 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14733 MAP2K7 S58 ochoa Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.
O14920 IKBKB S675 ochoa Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}.
O15049 N4BP3 S148 ochoa NEDD4-binding protein 3 (N4BP3) Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}.
O15061 SYNM S1184 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15350 TP73 S426 psp Tumor protein p73 (p53-like transcription factor) (p53-related protein) Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}.
O15533 TAPBP S359 ochoa Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848, ECO:0000269|PubMed:12582157, ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:26611325}.
O43390 HNRNPR Y431 ochoa Heterogeneous nuclear ribonucleoprotein R (hnRNP R) Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
O43566 RGS14 S45 ochoa Regulator of G-protein signaling 14 (RGS14) Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.
O43741 PRKAB2 S177 ochoa 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
O60239 SH3BP5 S354 ochoa SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}.
O60716 CTNND1 S349 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O60716 CTNND1 S352 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75044 SRGAP2 S799 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75064 DENND4B S1074 ochoa DENN domain-containing protein 4B Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.
O75376 NCOR1 S2358 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75674 TOM1L1 S314 ochoa TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.
O75886 STAM2 S375 ochoa Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
O95208 EPN2 S479 ochoa Epsin-2 (EPS-15-interacting protein 2) Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}.
O96005 CLPTM1 S27 ochoa Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}.
O96013 PAK4 S97 ochoa Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}.
P04350 TUBB4A S78 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P07437 TUBB S78 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P10398 ARAF S262 psp Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P11137 MAP2 S1611 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P14866 HNRNPL Y359 psp Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
P15056 BRAF S394 ochoa|psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P16144 ITGB4 S1212 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P17676 CEBPB S223 ochoa|psp CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}.
P18887 XRCC1 S229 ochoa DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}.
P19634 SLC9A1 S602 ochoa Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}.
P22681 CBL S486 ochoa E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P26640 VARS1 S617 ochoa Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}.
P27694 RPA1 S177 ochoa Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}.
P27816 MAP4 S510 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P38159 RBMX S88 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P38159 RBMX S287 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P42356 PI4KA S262 ochoa Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}.
P46937 YAP1 S131 ochoa|psp Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.
P49023 PXN S219 ochoa Paxillin Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
P49916 LIG3 S230 ochoa DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}.
P56945 BCAR1 S440 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P68371 TUBB4B S78 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78559 MAP1A S1160 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q03111 MLLT1 S265 ochoa Protein ENL (YEATS domain-containing protein 1) Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.
Q03164 KMT2A S3518 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05397 PTK2 S705 ochoa Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}.
Q06587 RING1 S190 ochoa E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Q07820 MCL1 S67 ochoa Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
Q08174 PCDH1 S1014 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q08174 PCDH1 S1021 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q08378 GOLGA3 S21 ochoa Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) Golgi auto-antigen; probably involved in maintaining Golgi structure.
Q10570 CPSF1 S756 ochoa Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}.
Q12923 PTPN13 S217 ochoa Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Q13148 TARDBP S350 psp TAR DNA-binding protein 43 (TDP-43) RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}.
Q13393 PLD1 S522 ochoa Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}.
Q13671 RIN1 S258 ochoa Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}.
Q13796 SHROOM2 S977 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13835 PKP1 S191 ochoa|psp Plakophilin-1 (Band 6 protein) (B6P) A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}.
Q13885 TUBB2A S78 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14004 CDK13 S328 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14004 CDK13 S388 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14160 SCRIB S1223 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14160 SCRIB S1298 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14185 DOCK1 S1761 ochoa Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}.
Q14687 GSE1 S87 ochoa Genetic suppressor element 1 None
Q14802 FXYD3 S69 ochoa FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.
Q16594 TAF9 S152 ochoa Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}.
Q4L180 FILIP1L S929 ochoa Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}.
Q5T5Y3 CAMSAP1 S506 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5TCX8 MAP3K21 S782 ochoa Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}.
Q5TGY3 AHDC1 S1014 ochoa Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}.
Q68EM7 ARHGAP17 S706 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6IBW4 NCAPH2 S328 ochoa Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}.
Q6IQ22 RAB12 S223 ochoa Ras-related protein Rab-12 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}.
Q6P2E9 EDC4 S774 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6PJG2 MIDEAS S648 ochoa Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) None
Q6WKZ4 RAB11FIP1 S392 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZRS2 SRCAP S2790 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZRV2 FAM83H S516 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q6ZTI6 RFLNA S28 ochoa Refilin-A (Regulator of filamin protein A) (RefilinA) Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}.
Q6ZTU2 EP400P1 S117 ochoa Putative EP400-like protein (EP400 pseudogene 1) None
Q6ZUT6 CCDC9B S451 ochoa Coiled-coil domain-containing protein 9B None
Q70E73 RAPH1 S1069 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q7LBC6 KDM3B S730 ochoa Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.
Q7RTP6 MICAL3 S1450 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q86TI0 TBC1D1 S573 ochoa TBC1 domain family member 1 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86TP1 PRUNE1 S396 ochoa Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.
Q86UY5 FAM83A S353 ochoa Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}.
Q86X10 RALGAPB S726 ochoa Ral GTPase-activating protein subunit beta (p170) Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q8IVJ1 SLC41A1 S76 ochoa Solute carrier family 41 member 1 Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}.
Q8N6T3 ARFGAP1 S128 ochoa ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
Q8N8E2 ZNF513 S99 ochoa Zinc finger protein 513 Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}.
Q8NAX2 KDF1 S160 ochoa Keratinocyte differentiation factor 1 Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}.
Q8NC24 RELL2 S52 ochoa RELT-like protein 2 Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.
Q8NCG7 DAGLB S579 ochoa Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}.
Q8NDT2 RBM15B S109 ochoa Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
Q8NDT2 RBM15B S231 ochoa Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
Q8NDT2 RBM15B S232 ochoa Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
Q8NDT2 RBM15B S233 ochoa Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
Q8NEZ4 KMT2C S2930 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NHM5 KDM2B S1018 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8TBP0 TBC1D16 S263 ochoa TBC1 domain family member 16 May act as a GTPase-activating protein for Rab family protein(s).
Q8TCZ2 CD99L2 S244 ochoa CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.
Q8TD16 BICD2 S611 ochoa Protein bicaudal D homolog 2 (Bic-D 2) Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}.
Q8WWM7 ATXN2L S426 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WWM7 ATXN2L S597 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q92844 TANK S228 ochoa TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.
Q92997 DVL3 S642 ochoa|psp Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
Q969S8 HDAC10 S371 ochoa Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}.
Q96AG3 SLC25A46 S37 ochoa Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}.
Q96AP7 ESAM S315 ochoa Endothelial cell-selective adhesion molecule Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}.
Q96B33 CLDN23 S206 ochoa Claudin-23 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.
Q96CB8 INTS12 S353 ochoa Integrator complex subunit 12 (Int12) (PHD finger protein 22) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.
Q96D71 REPS1 S120 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96D71 REPS1 S540 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96E39 RBMXL1 S88 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96E39 RBMXL1 S287 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96HR8 NAF1 S34 ochoa H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}.
Q96L91 EP400 S128 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96PU5 NEDD4L S184 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96T58 SPEN S3436 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99759 MAP3K3 S169 ochoa Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}.
Q9BQI5 SGIP1 S486 ochoa SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}.
Q9BQK8 LPIN3 S224 ochoa Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}.
Q9BRK4 LZTS2 S304 ochoa Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BRK4 LZTS2 S305 ochoa Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BRK4 LZTS2 S306 ochoa Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
Q9BVA1 TUBB2B S78 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9BX66 SORBS1 S235 ochoa Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}.
Q9C0B0 UNK S378 ochoa|psp RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0B5 ZDHHC5 S305 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0B5 ZDHHC5 S682 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0C2 TNKS1BP1 S1141 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0K0 BCL11B S258 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9C0K0 BCL11B S401 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H165 BCL11A S633 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H211 CDT1 S394 ochoa|psp DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H2G4 TSPYL2 S20 ochoa|psp Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.
Q9H3Q1 CDC42EP4 S315 ochoa Cdc42 effector protein 4 (Binder of Rho GTPases 4) Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Q9HC35 EML4 S891 ochoa Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.
Q9HCU4 CELSR2 S2668 ochoa Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9NQC7 CYLD S392 ochoa Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}.
Q9NQV6 PRDM10 T823 ochoa PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}.
Q9NR48 ASH1L S548 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9P246 STIM2 S602 ochoa Stromal interaction molecule 2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Q9P2G1 ANKIB1 S441 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UBY9 HSPB7 S49 ochoa Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) None
Q9UGP4 LIMD1 S387 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UGP4 LIMD1 S424 ochoa|psp LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UHF7 TRPS1 S181 ochoa Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}.
Q9UJM3 ERRFI1 S276 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9ULH1 ASAP1 S782 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9ULH1 ASAP1 S785 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9ULH1 ASAP1 S819 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9ULH1 ASAP1 S820 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9UMN6 KMT2B S1890 ochoa Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q9UPT8 ZC3H4 Y162 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9UPW6 SATB2 S593 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9UQ35 SRRM2 S300 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2K6 USP20 S105 ochoa Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}.
Q9Y2U8 LEMD3 S402 ochoa|psp Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y3Q8 TSC22D4 S145 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y3S1 WNK2 S1846 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4F1 FARP1 S23 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4H2 IRS2 S645 ochoa|psp Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y4I1 MYO5A S603 ochoa Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}.
Q9Y4U1 MMACHC S247 ochoa Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}.
Q9Y5S2 CDC42BPB S1680 ochoa|psp Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q9Y6W5 WASF2 S292 ochoa Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.
Q9Y6W5 WASF2 S296 ochoa Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}.
P23246 SFPQ Y251 Sugiyama Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.
Q06187 BTK S557 Sugiyama Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
Q9UK32 RPS6KA6 S712 Sugiyama Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
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reactome_id name p -log10_p
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 3.687125e-07 6.433
R-HSA-9619483 Activation of AMPK downstream of NMDARs 2.550732e-06 5.593
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 5.353829e-06 5.271
R-HSA-199991 Membrane Trafficking 5.143013e-06 5.289
R-HSA-190872 Transport of connexons to the plasma membrane 6.627391e-06 5.179
R-HSA-4839726 Chromatin organization 1.059311e-05 4.975
R-HSA-438064 Post NMDA receptor activation events 1.329866e-05 4.876
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.995378e-05 4.700
R-HSA-437239 Recycling pathway of L1 3.779950e-05 4.423
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 4.187062e-05 4.378
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 7.943332e-05 4.100
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 8.064498e-05 4.093
R-HSA-190861 Gap junction assembly 1.017437e-04 3.992
R-HSA-5653656 Vesicle-mediated transport 1.268818e-04 3.897
R-HSA-3247509 Chromatin modifying enzymes 1.336667e-04 3.874
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.853720e-04 3.732
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 2.049401e-04 3.688
R-HSA-6807878 COPI-mediated anterograde transport 2.049401e-04 3.688
R-HSA-9646399 Aggrephagy 1.910297e-04 3.719
R-HSA-3214841 PKMTs methylate histone lysines 2.103737e-04 3.677
R-HSA-8856688 Golgi-to-ER retrograde transport 2.624013e-04 3.581
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.673888e-04 3.573
R-HSA-190828 Gap junction trafficking 3.030435e-04 3.518
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.243943e-04 3.489
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 3.683567e-04 3.434
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 3.906955e-04 3.408
R-HSA-157858 Gap junction trafficking and regulation 4.589458e-04 3.338
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.711399e-04 3.327
R-HSA-9833482 PKR-mediated signaling 4.711399e-04 3.327
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 7.794926e-04 3.108
R-HSA-9663891 Selective autophagy 7.794926e-04 3.108
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 8.030480e-04 3.095
R-HSA-983189 Kinesins 1.006905e-03 2.997
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.143721e-03 2.942
R-HSA-8848021 Signaling by PTK6 1.217071e-03 2.915
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 1.217071e-03 2.915
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.277926e-03 2.893
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.637109e-03 2.786
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 1.842439e-03 2.735
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.182574e-03 2.661
R-HSA-9700206 Signaling by ALK in cancer 2.182574e-03 2.661
R-HSA-8856828 Clathrin-mediated endocytosis 2.189387e-03 2.660
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 2.369433e-03 2.625
R-HSA-199977 ER to Golgi Anterograde Transport 2.507177e-03 2.601
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 2.798205e-03 2.553
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.239514e-03 2.490
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.141228e-03 2.503
R-HSA-373760 L1CAM interactions 3.363034e-03 2.473
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 3.446337e-03 2.463
R-HSA-8876384 Listeria monocytogenes entry into host cells 3.446337e-03 2.463
R-HSA-5620924 Intraflagellar transport 3.587871e-03 2.445
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 4.424019e-03 2.354
R-HSA-194138 Signaling by VEGF 4.799278e-03 2.319
R-HSA-162582 Signal Transduction 4.922137e-03 2.308
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 5.588735e-03 2.253
R-HSA-177929 Signaling by EGFR 5.721817e-03 2.242
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 5.831155e-03 2.234
R-HSA-9660537 Signaling by MRAS-complex mutants 6.713996e-03 2.173
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 6.713996e-03 2.173
R-HSA-9700645 ALK mutants bind TKIs 7.933103e-03 2.101
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... 7.933103e-03 2.101
R-HSA-428543 Inactivation of CDC42 and RAC1 7.933103e-03 2.101
R-HSA-9616222 Transcriptional regulation of granulopoiesis 7.785905e-03 2.109
R-HSA-1632852 Macroautophagy 8.451830e-03 2.073
R-HSA-5617833 Cilium Assembly 8.815923e-03 2.055
R-HSA-68877 Mitotic Prometaphase 9.481425e-03 2.023
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.028780e-02 1.988
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 1.151198e-02 1.939
R-HSA-948021 Transport to the Golgi and subsequent modification 1.169877e-02 1.932
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.242740e-02 1.906
R-HSA-9612973 Autophagy 1.308678e-02 1.883
R-HSA-69278 Cell Cycle, Mitotic 1.347793e-02 1.870
R-HSA-1852241 Organelle biogenesis and maintenance 1.351608e-02 1.869
R-HSA-68886 M Phase 1.429553e-02 1.845
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.536189e-02 1.814
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.602519e-02 1.795
R-HSA-73933 Resolution of Abasic Sites (AP sites) 1.638696e-02 1.786
R-HSA-9675108 Nervous system development 1.645986e-02 1.784
R-HSA-418885 DCC mediated attractive signaling 1.891733e-02 1.723
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 1.891733e-02 1.723
R-HSA-1295596 Spry regulation of FGF signaling 1.891733e-02 1.723
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.734448e-02 1.761
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.891733e-02 1.723
R-HSA-2132295 MHC class II antigen presentation 1.834912e-02 1.736
R-HSA-8878171 Transcriptional regulation by RUNX1 1.979915e-02 1.703
R-HSA-9675151 Disorders of Developmental Biology 2.278286e-02 1.642
R-HSA-390466 Chaperonin-mediated protein folding 2.216581e-02 1.654
R-HSA-1483148 Synthesis of PG 2.278286e-02 1.642
R-HSA-75153 Apoptotic execution phase 2.225345e-02 1.653
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.363988e-02 1.626
R-HSA-422475 Axon guidance 2.329960e-02 1.633
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 2.107704e-02 1.676
R-HSA-381038 XBP1(S) activates chaperone genes 2.143400e-02 1.669
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.482720e-02 1.605
R-HSA-381070 IRE1alpha activates chaperones 2.605284e-02 1.584
R-HSA-69275 G2/M Transition 2.664245e-02 1.574
R-HSA-391251 Protein folding 2.687626e-02 1.571
R-HSA-4419969 Depolymerization of the Nuclear Lamina 2.694347e-02 1.570
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 2.694347e-02 1.570
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 3.244044e-02 1.489
R-HSA-3359473 Defective MMADHC causes MMAHCD 3.244044e-02 1.489
R-HSA-5602636 IKBKB deficiency causes SCID 3.244044e-02 1.489
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 3.138466e-02 1.503
R-HSA-6807004 Negative regulation of MET activity 3.138466e-02 1.503
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.126256e-02 1.505
R-HSA-9664407 Parasite infection 3.054594e-02 1.515
R-HSA-9664422 FCGR3A-mediated phagocytosis 3.054594e-02 1.515
R-HSA-9664417 Leishmania phagocytosis 3.054594e-02 1.515
R-HSA-453274 Mitotic G2-G2/M phases 2.774966e-02 1.557
R-HSA-8953897 Cellular responses to stimuli 3.228765e-02 1.491
R-HSA-381119 Unfolded Protein Response (UPR) 2.983977e-02 1.525
R-HSA-9609690 HCMV Early Events 3.248185e-02 1.488
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 3.424896e-02 1.465
R-HSA-5610787 Hedgehog 'off' state 3.498743e-02 1.456
R-HSA-112315 Transmission across Chemical Synapses 3.690009e-02 1.433
R-HSA-350054 Notch-HLH transcription pathway 3.854196e-02 1.414
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.241077e-02 1.373
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 5.348384e-02 1.272
R-HSA-3359474 Defective MMACHC causes MAHCC 5.348384e-02 1.272
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 5.348384e-02 1.272
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 5.348384e-02 1.272
R-HSA-74713 IRS activation 7.407210e-02 1.130
R-HSA-9706377 FLT3 signaling by CBL mutants 7.407210e-02 1.130
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 8.419862e-02 1.075
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 8.419862e-02 1.075
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 9.421501e-02 1.026
R-HSA-9027283 Erythropoietin activates STAT5 9.421501e-02 1.026
R-HSA-112412 SOS-mediated signalling 1.041225e-01 0.982
R-HSA-446107 Type I hemidesmosome assembly 1.139221e-01 0.943
R-HSA-444257 RSK activation 1.139221e-01 0.943
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 1.139221e-01 0.943
R-HSA-201688 WNT mediated activation of DVL 1.236152e-01 0.908
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.332029e-01 0.875
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 1.520664e-01 0.818
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.520664e-01 0.818
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1.613445e-01 0.792
R-HSA-9027284 Erythropoietin activates RAS 1.885775e-01 0.725
R-HSA-8964315 G beta:gamma signalling through BTK 1.885775e-01 0.725
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 6.920868e-02 1.160
R-HSA-5656121 Translesion synthesis by POLI 1.974583e-01 0.705
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.974583e-01 0.705
R-HSA-77595 Processing of Intronless Pre-mRNAs 2.062424e-01 0.686
R-HSA-5655862 Translesion synthesis by POLK 2.062424e-01 0.686
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 8.507168e-02 1.070
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.427147e-02 1.354
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.427147e-02 1.354
R-HSA-8854518 AURKA Activation by TPX2 4.896567e-02 1.310
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 6.081823e-02 1.216
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.195589e-01 0.922
R-HSA-9649948 Signaling downstream of RAS mutants 1.195589e-01 0.922
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.195589e-01 0.922
R-HSA-380287 Centrosome maturation 6.442929e-02 1.191
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.919074e-01 0.717
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 2.078272e-01 0.682
R-HSA-182971 EGFR downregulation 6.317070e-02 1.199
R-HSA-72163 mRNA Splicing - Major Pathway 2.081799e-01 0.682
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 9.665305e-02 1.015
R-HSA-9656223 Signaling by RAF1 mutants 1.019043e-01 0.992
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 2.004502e-01 0.698
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 2.004502e-01 0.698
R-HSA-5674135 MAP2K and MAPK activation 1.019043e-01 0.992
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 2.004502e-01 0.698
R-HSA-9762292 Regulation of CDH11 function 1.332029e-01 0.875
R-HSA-198203 PI3K/AKT activation 1.332029e-01 0.875
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.426862e-01 0.846
R-HSA-110312 Translesion synthesis by REV1 1.885775e-01 0.725
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 8.185235e-02 1.087
R-HSA-6802949 Signaling by RAS mutants 1.195589e-01 0.922
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 1.236152e-01 0.908
R-HSA-9796292 Formation of axial mesoderm 1.705217e-01 0.768
R-HSA-69166 Removal of the Flap Intermediate 1.795990e-01 0.746
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 2.062424e-01 0.686
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 2.149310e-01 0.668
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 1.520664e-01 0.818
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 2.062424e-01 0.686
R-HSA-68962 Activation of the pre-replicative complex 6.022294e-02 1.220
R-HSA-9664420 Killing mechanisms 1.974583e-01 0.705
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.974583e-01 0.705
R-HSA-5673000 RAF activation 7.542750e-02 1.122
R-HSA-5619507 Activation of HOX genes during differentiation 1.365815e-01 0.865
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 1.365815e-01 0.865
R-HSA-140342 Apoptosis induced DNA fragmentation 1.332029e-01 0.875
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 9.846751e-02 1.007
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.795990e-01 0.746
R-HSA-9758274 Regulation of NF-kappa B signaling 1.974583e-01 0.705
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 4.301965e-02 1.366
R-HSA-5603029 IkBA variant leads to EDA-ID 8.419862e-02 1.075
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.332029e-01 0.875
R-HSA-209560 NF-kB is activated and signals survival 1.520664e-01 0.818
R-HSA-5654732 Negative regulation of FGFR3 signaling 5.447696e-02 1.264
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.705217e-01 0.768
R-HSA-5654733 Negative regulation of FGFR4 signaling 5.732455e-02 1.242
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.885775e-01 0.725
R-HSA-5654727 Negative regulation of FGFR2 signaling 7.542750e-02 1.122
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 1.147873e-01 0.940
R-HSA-5654726 Negative regulation of FGFR1 signaling 6.920868e-02 1.160
R-HSA-170968 Frs2-mediated activation 1.705217e-01 0.768
R-HSA-212165 Epigenetic regulation of gene expression 1.781061e-01 0.749
R-HSA-74749 Signal attenuation 1.332029e-01 0.875
R-HSA-69183 Processive synthesis on the lagging strand 1.885775e-01 0.725
R-HSA-5602358 Diseases associated with the TLR signaling cascade 9.506467e-02 1.022
R-HSA-5260271 Diseases of Immune System 9.506467e-02 1.022
R-HSA-169893 Prolonged ERK activation events 1.974583e-01 0.705
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 6.442929e-02 1.191
R-HSA-139915 Activation of PUMA and translocation to mitochondria 1.041225e-01 0.982
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 5.168164e-02 1.287
R-HSA-3214815 HDACs deacetylate histones 1.529854e-01 0.815
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 1.810965e-01 0.742
R-HSA-5357905 Regulation of TNFR1 signaling 1.195589e-01 0.922
R-HSA-2980766 Nuclear Envelope Breakdown 1.606450e-01 0.794
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 1.810965e-01 0.742
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 1.893283e-01 0.723
R-HSA-5696398 Nucleotide Excision Repair 1.390860e-01 0.857
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 1.893283e-01 0.723
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1.116999e-01 0.952
R-HSA-1236974 ER-Phagosome pathway 9.447540e-02 1.025
R-HSA-68875 Mitotic Prophase 1.838295e-01 0.736
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 8.185235e-02 1.087
R-HSA-75893 TNF signaling 1.568062e-01 0.805
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 1.518374e-01 0.819
R-HSA-5674499 Negative feedback regulation of MAPK pathway 8.419862e-02 1.075
R-HSA-187706 Signalling to p38 via RIT and RIN 8.419862e-02 1.075
R-HSA-170984 ARMS-mediated activation 1.236152e-01 0.908
R-HSA-426048 Arachidonate production from DAG 1.332029e-01 0.875
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 1.520664e-01 0.818
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 1.885775e-01 0.725
R-HSA-354192 Integrin signaling 6.920868e-02 1.160
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 2.062424e-01 0.686
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 8.185235e-02 1.087
R-HSA-166166 MyD88-independent TLR4 cascade 1.518374e-01 0.819
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1.390860e-01 0.857
R-HSA-76009 Platelet Aggregation (Plug Formation) 1.159689e-01 0.936
R-HSA-5675221 Negative regulation of MAPK pathway 1.019043e-01 0.992
R-HSA-373752 Netrin-1 signaling 1.124073e-01 0.949
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 5.447696e-02 1.264
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.795990e-01 0.746
R-HSA-5693538 Homology Directed Repair 1.783747e-01 0.749
R-HSA-168898 Toll-like Receptor Cascades 2.014036e-01 0.696
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1.139221e-01 0.943
R-HSA-425986 Sodium/Proton exchangers 1.139221e-01 0.943
R-HSA-428540 Activation of RAC1 1.520664e-01 0.818
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.613445e-01 0.792
R-HSA-937039 IRAK1 recruits IKK complex 1.613445e-01 0.792
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 1.795990e-01 0.746
R-HSA-9706369 Negative regulation of FLT3 1.974583e-01 0.705
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 9.169696e-02 1.038
R-HSA-445355 Smooth Muscle Contraction 1.454016e-01 0.837
R-HSA-2467813 Separation of Sister Chromatids 5.167209e-02 1.287
R-HSA-3214842 HDMs demethylate histones 4.625375e-02 1.335
R-HSA-1251985 Nuclear signaling by ERBB4 9.506467e-02 1.022
R-HSA-2028269 Signaling by Hippo 2.149310e-01 0.668
R-HSA-193639 p75NTR signals via NF-kB 1.885775e-01 0.725
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 2.149310e-01 0.668
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 4.896567e-02 1.310
R-HSA-8941326 RUNX2 regulates bone development 8.181655e-02 1.087
R-HSA-9764302 Regulation of CDH19 Expression and Function 8.419862e-02 1.075
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 8.419862e-02 1.075
R-HSA-9613354 Lipophagy 1.236152e-01 0.908
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1.426862e-01 0.846
R-HSA-1483248 Synthesis of PIPs at the ER membrane 1.426862e-01 0.846
R-HSA-9005895 Pervasive developmental disorders 1.613445e-01 0.792
R-HSA-9697154 Disorders of Nervous System Development 1.613445e-01 0.792
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 1.613445e-01 0.792
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.705217e-01 0.768
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 2.149310e-01 0.668
R-HSA-429914 Deadenylation-dependent mRNA decay 1.683734e-01 0.774
R-HSA-6806834 Signaling by MET 7.387695e-02 1.131
R-HSA-2559583 Cellular Senescence 6.992808e-02 1.155
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1.101386e-01 0.958
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 6.616641e-02 1.179
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1.159689e-01 0.936
R-HSA-446652 Interleukin-1 family signaling 1.189660e-01 0.925
R-HSA-5654743 Signaling by FGFR4 1.088754e-01 0.963
R-HSA-9658195 Leishmania infection 1.162134e-01 0.935
R-HSA-9824443 Parasitic Infection Pathways 1.162134e-01 0.935
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 8.419862e-02 1.075
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 2.149310e-01 0.668
R-HSA-5654741 Signaling by FGFR3 1.159689e-01 0.936
R-HSA-1236975 Antigen processing-Cross presentation 1.466922e-01 0.834
R-HSA-9932451 SWI/SNF chromatin remodelers 4.625375e-02 1.335
R-HSA-9932444 ATP-dependent chromatin remodelers 4.625375e-02 1.335
R-HSA-5654736 Signaling by FGFR1 1.568062e-01 0.805
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 7.407210e-02 1.130
R-HSA-9635465 Suppression of apoptosis 1.426862e-01 0.846
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 8.597400e-02 1.066
R-HSA-73884 Base Excision Repair 9.665305e-02 1.015
R-HSA-1640170 Cell Cycle 5.998160e-02 1.222
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 1.088754e-01 0.963
R-HSA-69206 G1/S Transition 2.004502e-01 0.698
R-HSA-9816359 Maternal to zygotic transition (MZT) 1.920937e-01 0.716
R-HSA-1433559 Regulation of KIT signaling 1.795990e-01 0.746
R-HSA-450294 MAP kinase activation 1.761641e-01 0.754
R-HSA-68882 Mitotic Anaphase 4.730384e-02 1.325
R-HSA-2555396 Mitotic Metaphase and Anaphase 4.809889e-02 1.318
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.974583e-01 0.705
R-HSA-9860931 Response of endothelial cells to shear stress 1.340928e-01 0.873
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 8.806746e-02 1.055
R-HSA-9007101 Rab regulation of trafficking 5.757742e-02 1.240
R-HSA-448424 Interleukin-17 signaling 2.118295e-01 0.674
R-HSA-209543 p75NTR recruits signalling complexes 1.613445e-01 0.792
R-HSA-168638 NOD1/2 Signaling Pathway 7.542750e-02 1.122
R-HSA-170834 Signaling by TGF-beta Receptor Complex 1.171392e-01 0.931
R-HSA-2586552 Signaling by Leptin 1.332029e-01 0.875
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.139221e-01 0.943
R-HSA-391160 Signal regulatory protein family interactions 1.795990e-01 0.746
R-HSA-446353 Cell-extracellular matrix interactions 1.885775e-01 0.725
R-HSA-1266738 Developmental Biology 6.176483e-02 1.209
R-HSA-112316 Neuronal System 1.723379e-01 0.764
R-HSA-9855142 Cellular responses to mechanical stimuli 1.622965e-01 0.790
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1.568062e-01 0.805
R-HSA-9609646 HCMV Infection 7.900588e-02 1.102
R-HSA-2262752 Cellular responses to stress 6.620586e-02 1.179
R-HSA-9909648 Regulation of PD-L1(CD274) expression 1.602272e-01 0.795
R-HSA-109581 Apoptosis 1.379909e-01 0.860
R-HSA-9008059 Interleukin-37 signaling 6.022294e-02 1.220
R-HSA-69205 G1/S-Specific Transcription 8.181655e-02 1.087
R-HSA-425410 Metal ion SLC transporters 1.268202e-01 0.897
R-HSA-1643685 Disease 2.060532e-01 0.686
R-HSA-1483166 Synthesis of PA 1.606450e-01 0.794
R-HSA-5637810 Constitutive Signaling by EGFRvIII 2.149310e-01 0.668
R-HSA-5637812 Signaling by EGFRvIII in Cancer 2.149310e-01 0.668
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.304895e-01 0.884
R-HSA-9856651 MITF-M-dependent gene expression 1.153075e-01 0.938
R-HSA-111465 Apoptotic cleavage of cellular proteins 6.616641e-02 1.179
R-HSA-5633007 Regulation of TP53 Activity 1.340912e-01 0.873
R-HSA-1059683 Interleukin-6 signaling 1.705217e-01 0.768
R-HSA-5210891 Uptake and function of anthrax toxins 2.149310e-01 0.668
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.722613e-01 0.764
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1.722613e-01 0.764
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1.722613e-01 0.764
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.722613e-01 0.764
R-HSA-5663205 Infectious disease 1.827324e-01 0.738
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 1.879532e-01 0.726
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 1.268202e-01 0.897
R-HSA-2644603 Signaling by NOTCH1 in Cancer 1.722613e-01 0.764
R-HSA-5358351 Signaling by Hedgehog 9.280359e-02 1.032
R-HSA-446203 Asparagine N-linked glycosylation 2.167057e-01 0.664
R-HSA-9843745 Adipogenesis 2.202686e-01 0.657
R-HSA-389948 Co-inhibition by PD-1 2.219248e-01 0.654
R-HSA-168256 Immune System 2.225077e-01 0.653
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.235249e-01 0.651
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 2.235249e-01 0.651
R-HSA-5358508 Mismatch Repair 2.235249e-01 0.651
R-HSA-180292 GAB1 signalosome 2.235249e-01 0.651
R-HSA-674695 RNA Polymerase II Pre-transcription Events 2.279085e-01 0.642
R-HSA-1236394 Signaling by ERBB4 2.279085e-01 0.642
R-HSA-912631 Regulation of signaling by CBL 2.320254e-01 0.634
R-HSA-110320 Translesion Synthesis by POLH 2.320254e-01 0.634
R-HSA-937041 IKK complex recruitment mediated by RIP1 2.320254e-01 0.634
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 2.320254e-01 0.634
R-HSA-72172 mRNA Splicing 2.335586e-01 0.632
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.337315e-01 0.631
R-HSA-5357801 Programmed Cell Death 2.359034e-01 0.627
R-HSA-1980143 Signaling by NOTCH1 2.359812e-01 0.627
R-HSA-5620916 VxPx cargo-targeting to cilium 2.404332e-01 0.619
R-HSA-4086400 PCP/CE pathway 2.440698e-01 0.612
R-HSA-5602498 MyD88 deficiency (TLR2/4) 2.487496e-01 0.604
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.487496e-01 0.604
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.487496e-01 0.604
R-HSA-69186 Lagging Strand Synthesis 2.487496e-01 0.604
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 2.487496e-01 0.604
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 2.487496e-01 0.604
R-HSA-9819196 Zygotic genome activation (ZGA) 2.487496e-01 0.604
R-HSA-5654738 Signaling by FGFR2 2.521698e-01 0.598
R-HSA-5673001 RAF/MAP kinase cascade 2.540608e-01 0.595
R-HSA-9730414 MITF-M-regulated melanocyte development 2.548572e-01 0.594
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 2.569754e-01 0.590
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 2.569754e-01 0.590
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 2.569754e-01 0.590
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 2.569754e-01 0.590
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.569754e-01 0.590
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 2.602769e-01 0.585
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 2.651116e-01 0.577
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 2.651116e-01 0.577
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.651116e-01 0.577
R-HSA-1483257 Phospholipid metabolism 2.664661e-01 0.574
R-HSA-5684996 MAPK1/MAPK3 signaling 2.685472e-01 0.571
R-HSA-453279 Mitotic G1 phase and G1/S transition 2.698136e-01 0.569
R-HSA-6802957 Oncogenic MAPK signaling 2.724418e-01 0.565
R-HSA-109582 Hemostasis 2.726816e-01 0.564
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 2.731592e-01 0.564
R-HSA-200425 Carnitine shuttle 2.731592e-01 0.564
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2.731592e-01 0.564
R-HSA-3000170 Syndecan interactions 2.731592e-01 0.564
R-HSA-982772 Growth hormone receptor signaling 2.731592e-01 0.564
R-HSA-6798695 Neutrophil degranulation 2.740862e-01 0.562
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.805490e-01 0.552
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 2.811192e-01 0.551
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.811192e-01 0.551
R-HSA-933542 TRAF6 mediated NF-kB activation 2.811192e-01 0.551
R-HSA-429947 Deadenylation of mRNA 2.811192e-01 0.551
R-HSA-6783589 Interleukin-6 family signaling 2.811192e-01 0.551
R-HSA-449147 Signaling by Interleukins 2.816471e-01 0.550
R-HSA-9679191 Potential therapeutics for SARS 2.816710e-01 0.550
R-HSA-1280218 Adaptive Immune System 2.855248e-01 0.544
R-HSA-913531 Interferon Signaling 2.857449e-01 0.544
R-HSA-9620244 Long-term potentiation 2.889925e-01 0.539
R-HSA-420029 Tight junction interactions 2.889925e-01 0.539
R-HSA-3296469 Defects in cobalamin (B12) metabolism 2.889925e-01 0.539
R-HSA-2160916 Hyaluronan degradation 2.889925e-01 0.539
R-HSA-3000157 Laminin interactions 2.889925e-01 0.539
R-HSA-1266695 Interleukin-7 signaling 2.889925e-01 0.539
R-HSA-69306 DNA Replication 2.905956e-01 0.537
R-HSA-5693532 DNA Double-Strand Break Repair 2.905956e-01 0.537
R-HSA-8874081 MET activates PTK2 signaling 2.967801e-01 0.528
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 2.967801e-01 0.528
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.967801e-01 0.528
R-HSA-1643713 Signaling by EGFR in Cancer 2.967801e-01 0.528
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 2.967801e-01 0.528
R-HSA-73863 RNA Polymerase I Transcription Termination 3.044829e-01 0.516
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.044829e-01 0.516
R-HSA-9759218 Cobalamin (Cbl) metabolism 3.044829e-01 0.516
R-HSA-174414 Processive synthesis on the C-strand of the telomere 3.044829e-01 0.516
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 3.044829e-01 0.516
R-HSA-75109 Triglyceride biosynthesis 3.044829e-01 0.516
R-HSA-1483213 Synthesis of PE 3.044829e-01 0.516
R-HSA-264876 Insulin processing 3.044829e-01 0.516
R-HSA-1500931 Cell-Cell communication 3.108378e-01 0.507
R-HSA-9006936 Signaling by TGFB family members 3.114910e-01 0.507
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 3.121017e-01 0.506
R-HSA-168249 Innate Immune System 3.154980e-01 0.501
R-HSA-1280215 Cytokine Signaling in Immune system 3.185638e-01 0.497
R-HSA-9006335 Signaling by Erythropoietin 3.196376e-01 0.495
R-HSA-9709570 Impaired BRCA2 binding to RAD51 3.196376e-01 0.495
R-HSA-5656169 Termination of translesion DNA synthesis 3.196376e-01 0.495
R-HSA-9759475 Regulation of CDH11 Expression and Function 3.196376e-01 0.495
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 3.196376e-01 0.495
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.270913e-01 0.485
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 3.270913e-01 0.485
R-HSA-2424491 DAP12 signaling 3.270913e-01 0.485
R-HSA-114452 Activation of BH3-only proteins 3.270913e-01 0.485
R-HSA-162588 Budding and maturation of HIV virion 3.344639e-01 0.476
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 3.344639e-01 0.476
R-HSA-186763 Downstream signal transduction 3.344639e-01 0.476
R-HSA-975871 MyD88 cascade initiated on plasma membrane 3.369283e-01 0.472
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 3.369283e-01 0.472
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 3.369283e-01 0.472
R-HSA-190236 Signaling by FGFR 3.369283e-01 0.472
R-HSA-3214847 HATs acetylate histones 3.409140e-01 0.467
R-HSA-69190 DNA strand elongation 3.417561e-01 0.466
R-HSA-9020702 Interleukin-1 signaling 3.488631e-01 0.457
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 3.489689e-01 0.457
R-HSA-176187 Activation of ATR in response to replication stress 3.489689e-01 0.457
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 3.489689e-01 0.457
R-HSA-9930044 Nuclear RNA decay 3.489689e-01 0.457
R-HSA-397795 G-protein beta:gamma signalling 3.489689e-01 0.457
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 3.489689e-01 0.457
R-HSA-9022692 Regulation of MECP2 expression and activity 3.489689e-01 0.457
R-HSA-2559580 Oxidative Stress Induced Senescence 3.528258e-01 0.452
R-HSA-1483255 PI Metabolism 3.528258e-01 0.452
R-HSA-5689880 Ub-specific processing proteases 3.533561e-01 0.452
R-HSA-114508 Effects of PIP2 hydrolysis 3.561031e-01 0.448
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 3.561031e-01 0.448
R-HSA-5688426 Deubiquitination 3.578987e-01 0.446
R-HSA-388841 Regulation of T cell activation by CD28 family 3.603825e-01 0.443
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 3.607261e-01 0.443
R-HSA-5696400 Dual Incision in GG-NER 3.631595e-01 0.440
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 3.631595e-01 0.440
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 3.631595e-01 0.440
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.631595e-01 0.440
R-HSA-2142845 Hyaluronan metabolism 3.631595e-01 0.440
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 3.631595e-01 0.440
R-HSA-187687 Signalling to ERKs 3.701391e-01 0.432
R-HSA-3296482 Defects in vitamin and cofactor metabolism 3.701391e-01 0.432
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 3.701391e-01 0.432
R-HSA-381042 PERK regulates gene expression 3.701391e-01 0.432
R-HSA-69239 Synthesis of DNA 3.764180e-01 0.424
R-HSA-3371511 HSF1 activation 3.770425e-01 0.424
R-HSA-8853659 RET signaling 3.770425e-01 0.424
R-HSA-9682385 FLT3 signaling in disease 3.770425e-01 0.424
R-HSA-5683057 MAPK family signaling cascades 3.778675e-01 0.423
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 3.803168e-01 0.420
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 3.803168e-01 0.420
R-HSA-2672351 Stimuli-sensing channels 3.803168e-01 0.420
R-HSA-933541 TRAF6 mediated IRF7 activation 3.838708e-01 0.416
R-HSA-4641258 Degradation of DVL 3.838708e-01 0.416
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.838708e-01 0.416
R-HSA-5689896 Ovarian tumor domain proteases 3.838708e-01 0.416
R-HSA-69002 DNA Replication Pre-Initiation 3.842054e-01 0.415
R-HSA-975155 MyD88 dependent cascade initiated on endosome 3.842054e-01 0.415
R-HSA-8875878 MET promotes cell motility 3.906246e-01 0.408
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 3.906246e-01 0.408
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 3.973048e-01 0.401
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 3.973048e-01 0.401
R-HSA-8953750 Transcriptional Regulation by E2F6 3.973048e-01 0.401
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 3.996532e-01 0.398
R-HSA-983712 Ion channel transport 4.008128e-01 0.397
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 4.039121e-01 0.394
R-HSA-5696395 Formation of Incision Complex in GG-NER 4.039121e-01 0.394
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.039121e-01 0.394
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 4.104475e-01 0.387
R-HSA-8853884 Transcriptional Regulation by VENTX 4.104475e-01 0.387
R-HSA-9694548 Maturation of spike protein 4.104475e-01 0.387
R-HSA-9607240 FLT3 Signaling 4.104475e-01 0.387
R-HSA-5218920 VEGFR2 mediated vascular permeability 4.104475e-01 0.387
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4.111209e-01 0.386
R-HSA-446728 Cell junction organization 4.148185e-01 0.382
R-HSA-2029485 Role of phospholipids in phagocytosis 4.149198e-01 0.382
R-HSA-167161 HIV Transcription Initiation 4.169116e-01 0.380
R-HSA-75953 RNA Polymerase II Transcription Initiation 4.169116e-01 0.380
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 4.169116e-01 0.380
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 4.169116e-01 0.380
R-HSA-1592230 Mitochondrial biogenesis 4.224810e-01 0.374
R-HSA-73762 RNA Polymerase I Transcription Initiation 4.233052e-01 0.373
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 4.233052e-01 0.373
R-HSA-165159 MTOR signalling 4.233052e-01 0.373
R-HSA-379716 Cytosolic tRNA aminoacylation 4.233052e-01 0.373
R-HSA-73857 RNA Polymerase II Transcription 4.249190e-01 0.372
R-HSA-73776 RNA Polymerase II Promoter Escape 4.296291e-01 0.367
R-HSA-8854214 TBC/RABGAPs 4.296291e-01 0.367
R-HSA-9637690 Response of Mtb to phagocytosis 4.296291e-01 0.367
R-HSA-1433557 Signaling by SCF-KIT 4.296291e-01 0.367
R-HSA-8878166 Transcriptional regulation by RUNX2 4.299920e-01 0.367
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 4.358840e-01 0.361
R-HSA-2172127 DAP12 interactions 4.358840e-01 0.361
R-HSA-3928662 EPHB-mediated forward signaling 4.358840e-01 0.361
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 4.415411e-01 0.355
R-HSA-376176 Signaling by ROBO receptors 4.415411e-01 0.355
R-HSA-1483206 Glycerophospholipid biosynthesis 4.415411e-01 0.355
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 4.420707e-01 0.355
R-HSA-4608870 Asymmetric localization of PCP proteins 4.420707e-01 0.355
R-HSA-6783310 Fanconi Anemia Pathway 4.420707e-01 0.355
R-HSA-3700989 Transcriptional Regulation by TP53 4.447245e-01 0.352
R-HSA-2299718 Condensation of Prophase Chromosomes 4.481900e-01 0.349
R-HSA-9675135 Diseases of DNA repair 4.481900e-01 0.349
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 4.542425e-01 0.343
R-HSA-1483191 Synthesis of PC 4.542425e-01 0.343
R-HSA-983169 Class I MHC mediated antigen processing & presentation 4.576643e-01 0.339
R-HSA-73893 DNA Damage Bypass 4.661502e-01 0.331
R-HSA-9766229 Degradation of CDH1 4.661502e-01 0.331
R-HSA-187037 Signaling by NTRK1 (TRKA) 4.667501e-01 0.331
R-HSA-397014 Muscle contraction 4.699811e-01 0.328
R-HSA-109704 PI3K Cascade 4.720068e-01 0.326
R-HSA-9824439 Bacterial Infection Pathways 4.725004e-01 0.326
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 4.777995e-01 0.321
R-HSA-912446 Meiotic recombination 4.777995e-01 0.321
R-HSA-1169091 Activation of NF-kappaB in B cells 4.777995e-01 0.321
R-HSA-72187 mRNA 3'-end processing 4.835290e-01 0.316
R-HSA-112382 Formation of RNA Pol II elongation complex 4.835290e-01 0.316
R-HSA-73772 RNA Polymerase I Promoter Escape 4.835290e-01 0.316
R-HSA-68949 Orc1 removal from chromatin 4.835290e-01 0.316
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 4.835290e-01 0.316
R-HSA-5339562 Uptake and actions of bacterial toxins 4.835290e-01 0.316
R-HSA-9909396 Circadian clock 4.846007e-01 0.315
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 4.891960e-01 0.311
R-HSA-75955 RNA Polymerase II Transcription Elongation 4.891960e-01 0.311
R-HSA-9824446 Viral Infection Pathways 4.969817e-01 0.304
R-HSA-3858494 Beta-catenin independent WNT signaling 5.020794e-01 0.299
R-HSA-5578775 Ion homeostasis 5.058287e-01 0.296
R-HSA-109606 Intrinsic Pathway for Apoptosis 5.058287e-01 0.296
R-HSA-112399 IRS-mediated signalling 5.112524e-01 0.291
R-HSA-9764561 Regulation of CDH1 Function 5.112524e-01 0.291
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.112524e-01 0.291
R-HSA-6782135 Dual incision in TC-NER 5.166168e-01 0.287
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 5.166168e-01 0.287
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 5.166168e-01 0.287
R-HSA-180786 Extension of Telomeres 5.219228e-01 0.282
R-HSA-8979227 Triglyceride metabolism 5.219228e-01 0.282
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 5.219228e-01 0.282
R-HSA-162599 Late Phase of HIV Life Cycle 5.259037e-01 0.279
R-HSA-8873719 RAB geranylgeranylation 5.271708e-01 0.278
R-HSA-8943724 Regulation of PTEN gene transcription 5.271708e-01 0.278
R-HSA-379724 tRNA Aminoacylation 5.271708e-01 0.278
R-HSA-2428928 IRS-related events triggered by IGF1R 5.323615e-01 0.274
R-HSA-73856 RNA Polymerase II Transcription Termination 5.323615e-01 0.274
R-HSA-9707616 Heme signaling 5.374955e-01 0.270
R-HSA-375165 NCAM signaling for neurite out-growth 5.374955e-01 0.270
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 5.374955e-01 0.270
R-HSA-6784531 tRNA processing in the nucleus 5.374955e-01 0.270
R-HSA-186797 Signaling by PDGF 5.374955e-01 0.270
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 5.374955e-01 0.270
R-HSA-69242 S Phase 5.457084e-01 0.263
R-HSA-166520 Signaling by NTRKs 5.457084e-01 0.263
R-HSA-74751 Insulin receptor signalling cascade 5.475961e-01 0.262
R-HSA-2428924 IGF1R signaling cascade 5.475961e-01 0.262
R-HSA-936837 Ion transport by P-type ATPases 5.475961e-01 0.262
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 5.525638e-01 0.258
R-HSA-1234174 Cellular response to hypoxia 5.525638e-01 0.258
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 5.585897e-01 0.253
R-HSA-5685942 HDR through Homologous Recombination (HRR) 5.623371e-01 0.250
R-HSA-73887 Death Receptor Signaling 5.649329e-01 0.248
R-HSA-212436 Generic Transcription Pathway 5.662548e-01 0.247
R-HSA-167172 Transcription of the HIV genome 5.671439e-01 0.246
R-HSA-162587 HIV Life Cycle 5.743254e-01 0.241
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.766004e-01 0.239
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 5.766004e-01 0.239
R-HSA-9711097 Cellular response to starvation 5.774235e-01 0.239
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 5.774235e-01 0.239
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.812514e-01 0.236
R-HSA-427413 NoRC negatively regulates rRNA expression 5.812514e-01 0.236
R-HSA-69052 Switching of origins to a post-replicative state 5.904015e-01 0.229
R-HSA-69473 G2/M DNA damage checkpoint 5.949017e-01 0.226
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 5.993527e-01 0.222
R-HSA-3000171 Non-integrin membrane-ECM interactions 5.993527e-01 0.222
R-HSA-9734767 Developmental Cell Lineages 6.032647e-01 0.219
R-HSA-73854 RNA Polymerase I Promoter Clearance 6.037551e-01 0.219
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 6.081094e-01 0.216
R-HSA-9694635 Translation of Structural Proteins 6.081094e-01 0.216
R-HSA-73864 RNA Polymerase I Transcription 6.124161e-01 0.213
R-HSA-383280 Nuclear Receptor transcription pathway 6.124161e-01 0.213
R-HSA-416482 G alpha (12/13) signalling events 6.124161e-01 0.213
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 6.124161e-01 0.213
R-HSA-74160 Gene expression (Transcription) 6.130791e-01 0.212
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 6.208888e-01 0.207
R-HSA-5693607 Processing of DNA double-strand break ends 6.250559e-01 0.204
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 6.250559e-01 0.204
R-HSA-76002 Platelet activation, signaling and aggregation 6.289870e-01 0.201
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.291774e-01 0.201
R-HSA-9707564 Cytoprotection by HMOX1 6.332538e-01 0.198
R-HSA-1500620 Meiosis 6.412735e-01 0.193
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.452178e-01 0.190
R-HSA-201681 TCF dependent signaling in response to WNT 6.522149e-01 0.186
R-HSA-202424 Downstream TCR signaling 6.643013e-01 0.178
R-HSA-8986944 Transcriptional Regulation by MECP2 6.679937e-01 0.175
R-HSA-74752 Signaling by Insulin receptor 6.752577e-01 0.171
R-HSA-2682334 EPH-Ephrin signaling 6.752577e-01 0.171
R-HSA-9772573 Late SARS-CoV-2 Infection Events 6.752577e-01 0.171
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.755458e-01 0.170
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 6.788303e-01 0.168
R-HSA-68867 Assembly of the pre-replicative complex 6.788303e-01 0.168
R-HSA-195721 Signaling by WNT 6.810595e-01 0.167
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 6.823638e-01 0.166
R-HSA-1474290 Collagen formation 6.823638e-01 0.166
R-HSA-5607764 CLEC7A (Dectin-1) signaling 6.927339e-01 0.159
R-HSA-157579 Telomere Maintenance 6.961152e-01 0.157
R-HSA-8878159 Transcriptional regulation by RUNX3 6.961152e-01 0.157
R-HSA-193704 p75 NTR receptor-mediated signalling 7.027673e-01 0.153
R-HSA-9009391 Extra-nuclear estrogen signaling 7.092746e-01 0.149
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.124749e-01 0.147
R-HSA-8953854 Metabolism of RNA 7.287734e-01 0.137
R-HSA-202403 TCR signaling 7.397462e-01 0.131
R-HSA-2871796 FCERI mediated MAPK activation 7.454481e-01 0.128
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 7.510258e-01 0.124
R-HSA-162906 HIV Infection 7.564199e-01 0.121
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.564820e-01 0.121
R-HSA-2871809 FCERI mediated Ca+2 mobilization 7.591653e-01 0.120
R-HSA-9679506 SARS-CoV Infections 7.618919e-01 0.118
R-HSA-2980736 Peptide hormone metabolism 7.644441e-01 0.117
R-HSA-2219528 PI3K/AKT Signaling in Cancer 7.670402e-01 0.115
R-HSA-73886 Chromosome Maintenance 7.746589e-01 0.111
R-HSA-3371556 Cellular response to heat stress 7.746589e-01 0.111
R-HSA-9635486 Infection with Mycobacterium tuberculosis 7.746589e-01 0.111
R-HSA-202733 Cell surface interactions at the vascular wall 7.755784e-01 0.110
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.795999e-01 0.108
R-HSA-157118 Signaling by NOTCH 7.810651e-01 0.107
R-HSA-6809371 Formation of the cornified envelope 7.820299e-01 0.107
R-HSA-73894 DNA Repair 7.901532e-01 0.102
R-HSA-69481 G2/M Checkpoints 7.914861e-01 0.102
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.983096e-01 0.098
R-HSA-421270 Cell-cell junction organization 8.001938e-01 0.097
R-HSA-1474165 Reproduction 8.005344e-01 0.097
R-HSA-5576891 Cardiac conduction 8.027348e-01 0.095
R-HSA-163685 Integration of energy metabolism 8.154393e-01 0.089
R-HSA-416476 G alpha (q) signalling events 8.208890e-01 0.086
R-HSA-6807070 PTEN Regulation 8.214830e-01 0.085
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 8.292362e-01 0.081
R-HSA-2871837 FCERI mediated NF-kB activation 8.329863e-01 0.079
R-HSA-597592 Post-translational protein modification 8.352107e-01 0.078
R-HSA-9758941 Gastrulation 8.420071e-01 0.075
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.463850e-01 0.072
R-HSA-1989781 PPARA activates gene expression 8.521947e-01 0.069
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 8.554433e-01 0.068
R-HSA-1257604 PIP3 activates AKT signaling 8.627104e-01 0.064
R-HSA-72306 tRNA processing 8.762790e-01 0.057
R-HSA-5621481 C-type lectin receptors (CLRs) 8.776475e-01 0.057
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.803395e-01 0.055
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.803395e-01 0.055
R-HSA-1630316 Glycosaminoglycan metabolism 9.042222e-01 0.044
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 9.073700e-01 0.042
R-HSA-9006925 Intracellular signaling by second messengers 9.093704e-01 0.041
R-HSA-9694516 SARS-CoV-2 Infection 9.149010e-01 0.039
R-HSA-6805567 Keratinization 9.180569e-01 0.037
R-HSA-9006931 Signaling by Nuclear Receptors 9.250298e-01 0.034
R-HSA-418990 Adherens junctions interactions 9.283211e-01 0.032
R-HSA-9705683 SARS-CoV-2-host interactions 9.358904e-01 0.029
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.373060e-01 0.028
R-HSA-8939211 ESR-mediated signaling 9.420203e-01 0.026
R-HSA-425407 SLC-mediated transmembrane transport 9.456217e-01 0.024
R-HSA-69620 Cell Cycle Checkpoints 9.541504e-01 0.020
R-HSA-9711123 Cellular response to chemical stress 9.590036e-01 0.018
R-HSA-1474244 Extracellular matrix organization 9.797737e-01 0.009
R-HSA-196854 Metabolism of vitamins and cofactors 9.860457e-01 0.006
R-HSA-382551 Transport of small molecules 9.871778e-01 0.006
R-HSA-392499 Metabolism of proteins 9.878894e-01 0.005
R-HSA-418594 G alpha (i) signalling events 9.915036e-01 0.004
R-HSA-8978868 Fatty acid metabolism 9.915036e-01 0.004
R-HSA-5668914 Diseases of metabolism 9.932222e-01 0.003
R-HSA-388396 GPCR downstream signalling 9.933050e-01 0.003
R-HSA-72766 Translation 9.933737e-01 0.003
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.950628e-01 0.002
R-HSA-372790 Signaling by GPCR 9.969130e-01 0.001
R-HSA-556833 Metabolism of lipids 9.980942e-01 0.001
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CK1ECK1E 0.833 0.555 -3 0.727
CK1DCK1D 0.832 0.558 -3 0.733
CK1A2CK1A2 0.824 0.536 -3 0.733
KISKIS 0.822 0.262 1 0.816
CK1G1CK1G1 0.811 0.469 -3 0.710
GRK1GRK1 0.809 0.274 -2 0.735
CK1ACK1A 0.809 0.482 -3 0.731
COTCOT 0.807 0.145 2 0.830
CLK3CLK3 0.806 0.165 1 0.916
CDC7CDC7 0.802 0.138 1 0.852
MOSMOS 0.801 0.171 1 0.883
MTORMTOR 0.797 0.111 1 0.819
ERK5ERK5 0.795 0.141 1 0.895
HIPK4HIPK4 0.795 0.143 1 0.869
GRK7GRK7 0.795 0.211 1 0.784
CDKL1CDKL1 0.794 0.078 -3 0.313
IKKBIKKB 0.794 0.052 -2 0.625
CDKL5CDKL5 0.793 0.112 -3 0.299
GRK5GRK5 0.792 0.191 -3 0.459
PIM3PIM3 0.790 0.021 -3 0.344
DYRK2DYRK2 0.790 0.145 1 0.822
P38BP38B 0.789 0.228 1 0.781
PRPKPRPK 0.789 0.004 -1 0.832
BMPR1BBMPR1B 0.789 0.168 1 0.814
CDK1CDK1 0.789 0.179 1 0.782
NLKNLK 0.788 0.103 1 0.901
GRK6GRK6 0.788 0.209 1 0.829
CDK8CDK8 0.788 0.160 1 0.794
CDK19CDK19 0.787 0.171 1 0.764
SRPK1SRPK1 0.786 0.032 -3 0.304
ATRATR 0.786 0.054 1 0.845
NDR2NDR2 0.786 0.002 -3 0.336
HIPK2HIPK2 0.786 0.164 1 0.753
ICKICK 0.785 0.137 -3 0.328
GRK4GRK4 0.785 0.172 -2 0.716
ERK1ERK1 0.785 0.204 1 0.769
CDK18CDK18 0.785 0.180 1 0.759
RAF1RAF1 0.785 0.004 1 0.820
P38DP38D 0.784 0.206 1 0.721
JNK3JNK3 0.784 0.169 1 0.788
DSTYKDSTYK 0.784 -0.019 2 0.835
P38AP38A 0.784 0.212 1 0.838
IKKAIKKA 0.783 0.042 -2 0.641
JNK2JNK2 0.783 0.176 1 0.756
GRK3GRK3 0.781 0.192 -2 0.608
CK1G3CK1G3 0.781 0.454 -3 0.721
P38GP38G 0.780 0.175 1 0.704
PDHK4PDHK4 0.780 -0.120 1 0.845
MLK1MLK1 0.780 0.096 2 0.765
SKMLCKSKMLCK 0.779 0.003 -2 0.691
GRK2GRK2 0.779 0.143 -2 0.634
CAMK2GCAMK2G 0.779 -0.031 2 0.755
TBK1TBK1 0.779 -0.011 1 0.701
CLK2CLK2 0.778 0.078 -3 0.301
BMPR2BMPR2 0.778 -0.048 -2 0.715
DYRK4DYRK4 0.778 0.143 1 0.766
CHAK2CHAK2 0.777 0.038 -1 0.778
HIPK1HIPK1 0.777 0.122 1 0.834
IKKEIKKE 0.776 -0.038 1 0.695
RIPK3RIPK3 0.776 0.033 3 0.738
PIM1PIM1 0.776 0.003 -3 0.334
SRPK3SRPK3 0.776 0.010 -3 0.304
CAMK1BCAMK1B 0.776 -0.082 -3 0.339
MAKMAK 0.776 0.213 -2 0.833
CDK7CDK7 0.775 0.124 1 0.812
SRPK2SRPK2 0.775 -0.001 -3 0.263
RSK2RSK2 0.774 -0.044 -3 0.284
CDK17CDK17 0.774 0.154 1 0.712
FAM20CFAM20C 0.774 0.036 2 0.536
DYRK1ADYRK1A 0.773 0.107 1 0.844
GCN2GCN2 0.773 -0.124 2 0.753
CDK5CDK5 0.773 0.139 1 0.832
DLKDLK 0.772 0.081 1 0.811
PRP4PRP4 0.772 0.063 -3 0.318
NUAK2NUAK2 0.771 -0.050 -3 0.339
CDK13CDK13 0.770 0.103 1 0.787
JNK1JNK1 0.770 0.156 1 0.753
MLK3MLK3 0.770 0.048 2 0.691
NEK6NEK6 0.770 -0.092 -2 0.675
ERK2ERK2 0.769 0.147 1 0.804
WNK1WNK1 0.769 -0.049 -2 0.731
NIKNIK 0.768 -0.099 -3 0.348
ACVR2BACVR2B 0.768 0.068 -2 0.627
CK1G2CK1G2 0.768 0.388 -3 0.719
MST4MST4 0.768 -0.032 2 0.804
PRKD1PRKD1 0.768 -0.071 -3 0.281
DAPK2DAPK2 0.768 -0.077 -3 0.335
CDK14CDK14 0.768 0.140 1 0.791
PDHK1PDHK1 0.768 -0.192 1 0.817
ATMATM 0.768 0.015 1 0.782
P90RSKP90RSK 0.768 -0.065 -3 0.282
ALK4ALK4 0.767 0.020 -2 0.669
MAPKAPK2MAPKAPK2 0.767 -0.061 -3 0.258
CAMLCKCAMLCK 0.767 -0.081 -2 0.660
NDR1NDR1 0.767 -0.083 -3 0.320
CLK4CLK4 0.767 0.009 -3 0.313
PASKPASK 0.767 0.095 -3 0.370
BMPR1ABMPR1A 0.767 0.108 1 0.786
TGFBR1TGFBR1 0.767 0.009 -2 0.646
TTBK2TTBK2 0.766 -0.002 2 0.635
NEK7NEK7 0.766 -0.129 -3 0.340
CDK16CDK16 0.766 0.151 1 0.728
RSK4RSK4 0.765 -0.022 -3 0.283
ACVR2AACVR2A 0.765 0.066 -2 0.606
PKN2PKN2 0.765 -0.067 -3 0.335
PRKXPRKX 0.765 -0.023 -3 0.277
CDK3CDK3 0.765 0.123 1 0.731
PRKD2PRKD2 0.765 -0.074 -3 0.260
MASTLMASTL 0.765 -0.122 -2 0.669
PKN3PKN3 0.765 -0.093 -3 0.309
DYRK1BDYRK1B 0.764 0.096 1 0.795
BCKDKBCKDK 0.764 -0.103 -1 0.741
ULK2ULK2 0.764 -0.188 2 0.727
MARK4MARK4 0.764 -0.081 4 0.809
P70S6KBP70S6KB 0.764 -0.075 -3 0.295
MLK4MLK4 0.764 0.080 2 0.676
GSK3AGSK3A 0.764 0.109 4 0.550
MLK2MLK2 0.763 -0.025 2 0.763
PKACGPKACG 0.763 -0.061 -2 0.549
LATS1LATS1 0.763 -0.015 -3 0.325
HUNKHUNK 0.763 -0.115 2 0.767
AURCAURC 0.763 -0.036 -2 0.471
CDK12CDK12 0.763 0.098 1 0.761
MPSK1MPSK1 0.763 0.159 1 0.823
MEKK3MEKK3 0.763 0.151 1 0.782
TGFBR2TGFBR2 0.762 -0.100 -2 0.614
ALK2ALK2 0.762 0.033 -2 0.662
AMPKA1AMPKA1 0.762 -0.080 -3 0.330
CDK10CDK10 0.762 0.122 1 0.781
RIPK1RIPK1 0.762 -0.062 1 0.788
PKACBPKACB 0.762 -0.041 -2 0.471
LATS2LATS2 0.761 -0.077 -5 0.740
CAMK2ACAMK2A 0.761 -0.037 2 0.753
HIPK3HIPK3 0.761 0.079 1 0.816
RSK3RSK3 0.761 -0.088 -3 0.267
DYRK3DYRK3 0.761 0.058 1 0.825
SMG1SMG1 0.760 -0.010 1 0.799
CAMK2BCAMK2B 0.760 -0.041 2 0.728
CLK1CLK1 0.760 -0.005 -3 0.277
ANKRD3ANKRD3 0.759 -0.088 1 0.830
CAMK2DCAMK2D 0.759 -0.120 -3 0.300
MAPKAPK3MAPKAPK3 0.759 -0.122 -3 0.263
CK2A2CK2A2 0.759 0.097 1 0.733
IRE1IRE1 0.759 -0.024 1 0.791
CDK2CDK2 0.758 0.059 1 0.839
MEK1MEK1 0.758 0.024 2 0.794
ULK1ULK1 0.758 -0.172 -3 0.311
MSK1MSK1 0.758 -0.057 -3 0.283
YSK4YSK4 0.758 -0.036 1 0.750
AMPKA2AMPKA2 0.758 -0.080 -3 0.306
MSK2MSK2 0.757 -0.087 -3 0.296
PKRPKR 0.757 -0.017 1 0.834
GSK3BGSK3B 0.757 0.071 4 0.543
WNK3WNK3 0.756 -0.167 1 0.795
NEK9NEK9 0.756 -0.143 2 0.779
AKT2AKT2 0.756 -0.054 -3 0.265
PLK1PLK1 0.756 -0.073 -2 0.608
TLK2TLK2 0.755 -0.019 1 0.788
PAK1PAK1 0.755 -0.078 -2 0.615
VRK2VRK2 0.755 -0.079 1 0.870
CDK9CDK9 0.755 0.063 1 0.791
DNAPKDNAPK 0.755 0.007 1 0.719
GAKGAK 0.754 0.160 1 0.881
PKCDPKCD 0.754 -0.079 2 0.737
MYLK4MYLK4 0.754 -0.058 -2 0.570
CK2A1CK2A1 0.753 0.108 1 0.711
MST3MST3 0.753 0.073 2 0.800
QSKQSK 0.753 -0.065 4 0.780
MOKMOK 0.753 0.135 1 0.847
PKCBPKCB 0.752 -0.051 2 0.692
PIM2PIM2 0.752 -0.045 -3 0.273
TSSK2TSSK2 0.752 -0.096 -5 0.832
PKCGPKCG 0.752 -0.046 2 0.689
NIM1NIM1 0.752 -0.108 3 0.765
CAMK4CAMK4 0.751 -0.140 -3 0.322
DRAK1DRAK1 0.750 -0.030 1 0.767
MEKK2MEKK2 0.750 0.071 2 0.744
PKCAPKCA 0.750 -0.044 2 0.685
TSSK1TSSK1 0.749 -0.098 -3 0.328
SGK3SGK3 0.749 -0.075 -3 0.284
AURAAURA 0.749 -0.052 -2 0.437
ERK7ERK7 0.749 0.074 2 0.559
TLK1TLK1 0.748 -0.002 -2 0.667
PRKD3PRKD3 0.748 -0.105 -3 0.262
QIKQIK 0.748 -0.130 -3 0.317
MARK3MARK3 0.748 -0.059 4 0.740
PLK3PLK3 0.747 -0.090 2 0.727
PAK3PAK3 0.747 -0.122 -2 0.595
MEK5MEK5 0.747 -0.051 2 0.772
TAO3TAO3 0.747 0.015 1 0.784
AURBAURB 0.747 -0.072 -2 0.462
SIKSIK 0.746 -0.097 -3 0.284
PAK2PAK2 0.745 -0.097 -2 0.596
NUAK1NUAK1 0.745 -0.124 -3 0.280
BRSK1BRSK1 0.745 -0.108 -3 0.286
PKCZPKCZ 0.745 -0.070 2 0.734
PINK1PINK1 0.745 -0.118 1 0.878
PKG2PKG2 0.743 -0.090 -2 0.486
IRE2IRE2 0.743 -0.084 2 0.702
MELKMELK 0.743 -0.150 -3 0.279
BRAFBRAF 0.742 -0.106 -4 0.806
NEK11NEK11 0.742 0.000 1 0.770
YANK3YANK3 0.742 0.123 2 0.368
CHAK1CHAK1 0.742 -0.112 2 0.718
MNK1MNK1 0.742 -0.100 -2 0.595
PKACAPKACA 0.742 -0.075 -2 0.423
ZAKZAK 0.742 -0.053 1 0.743
PLK2PLK2 0.741 -0.018 -3 0.327
CAMK1GCAMK1G 0.741 -0.107 -3 0.283
MNK2MNK2 0.741 -0.120 -2 0.583
PHKG1PHKG1 0.741 -0.119 -3 0.320
GCKGCK 0.741 0.042 1 0.793
PKCHPKCH 0.740 -0.101 2 0.673
MARK2MARK2 0.740 -0.090 4 0.697
PERKPERK 0.740 -0.114 -2 0.670
NEK5NEK5 0.740 -0.095 1 0.818
MEKK1MEKK1 0.740 -0.099 1 0.780
CDK6CDK6 0.740 0.093 1 0.771
NEK2NEK2 0.739 -0.172 2 0.766
MAPKAPK5MAPKAPK5 0.739 -0.162 -3 0.244
AKT1AKT1 0.738 -0.075 -3 0.266
LKB1LKB1 0.738 -0.055 -3 0.311
TAK1TAK1 0.738 0.055 1 0.801
WNK4WNK4 0.738 -0.098 -2 0.733
BRSK2BRSK2 0.738 -0.139 -3 0.291
MARK1MARK1 0.738 -0.106 4 0.755
PAK6PAK6 0.737 -0.106 -2 0.512
DAPK3DAPK3 0.737 -0.060 -3 0.321
DAPK1DAPK1 0.737 -0.043 -3 0.328
DCAMKL1DCAMKL1 0.737 -0.125 -3 0.291
CAMKK1CAMKK1 0.737 -0.103 -2 0.640
SGK1SGK1 0.736 -0.053 -3 0.233
TTBK1TTBK1 0.736 -0.068 2 0.555
SMMLCKSMMLCK 0.736 -0.108 -3 0.308
P70S6KP70S6K 0.736 -0.098 -3 0.243
PLK4PLK4 0.736 -0.105 2 0.589
CHK1CHK1 0.734 -0.171 -3 0.260
HPK1HPK1 0.734 0.017 1 0.772
CAMKK2CAMKK2 0.733 -0.105 -2 0.635
CDK4CDK4 0.733 0.084 1 0.752
NEK8NEK8 0.733 -0.083 2 0.770
MST2MST2 0.733 -0.034 1 0.789
EEF2KEEF2K 0.733 0.008 3 0.779
HRIHRI 0.733 -0.192 -2 0.659
IRAK4IRAK4 0.732 -0.102 1 0.779
SNRKSNRK 0.732 -0.204 2 0.650
AKT3AKT3 0.731 -0.065 -3 0.241
ALPHAK3ALPHAK3 0.731 0.128 -1 0.771
PDK1PDK1 0.730 -0.081 1 0.769
PDHK3_TYRPDHK3_TYR 0.730 0.153 4 0.892
PDHK1_TYRPDHK1_TYR 0.729 0.233 -1 0.864
PDHK4_TYRPDHK4_TYR 0.729 0.218 2 0.843
MAP3K15MAP3K15 0.729 -0.030 1 0.735
MINKMINK 0.729 -0.021 1 0.767
MAP2K6_TYRMAP2K6_TYR 0.728 0.229 -1 0.846
TAO2TAO2 0.727 -0.109 2 0.791
PKCEPKCE 0.727 -0.061 2 0.676
CAMK1DCAMK1D 0.727 -0.121 -3 0.237
LRRK2LRRK2 0.727 -0.095 2 0.799
BMPR2_TYRBMPR2_TYR 0.727 0.117 -1 0.868
SSTKSSTK 0.726 -0.100 4 0.766
SBKSBK 0.726 -0.065 -3 0.196
MAP2K4_TYRMAP2K4_TYR 0.726 0.143 -1 0.847
TNIKTNIK 0.726 -0.046 3 0.817
PBKPBK 0.726 0.009 1 0.818
MEKK6MEKK6 0.725 -0.094 1 0.786
DCAMKL2DCAMKL2 0.725 -0.145 -3 0.290
CHK2CHK2 0.724 -0.100 -3 0.231
KHS2KHS2 0.724 0.009 1 0.778
PKCTPKCT 0.724 -0.121 2 0.679
PKCIPKCI 0.723 -0.099 2 0.706
VRK1VRK1 0.723 -0.087 2 0.792
NEK4NEK4 0.723 -0.135 1 0.768
HGKHGK 0.723 -0.079 3 0.820
ROCK2ROCK2 0.722 -0.062 -3 0.303
BUB1BUB1 0.722 -0.017 -5 0.791
SLKSLK 0.721 -0.063 -2 0.566
KHS1KHS1 0.721 -0.030 1 0.759
YANK2YANK2 0.720 0.143 2 0.376
MRCKAMRCKA 0.720 -0.088 -3 0.277
IRAK1IRAK1 0.720 -0.208 -1 0.688
MST1MST1 0.719 -0.090 1 0.768
PAK5PAK5 0.719 -0.121 -2 0.462
DMPK1DMPK1 0.719 -0.053 -3 0.298
PHKG2PHKG2 0.719 -0.155 -3 0.295
MRCKBMRCKB 0.719 -0.090 -3 0.271
OSR1OSR1 0.719 0.002 2 0.756
TTKTTK 0.718 0.024 -2 0.637
TESK1_TYRTESK1_TYR 0.716 -0.027 3 0.863
NEK1NEK1 0.716 -0.168 1 0.779
PKMYT1_TYRPKMYT1_TYR 0.715 -0.021 3 0.838
HASPINHASPIN 0.715 0.009 -1 0.659
PAK4PAK4 0.715 -0.112 -2 0.466
STK33STK33 0.715 -0.107 2 0.565
MAP2K7_TYRMAP2K7_TYR 0.714 -0.051 2 0.804
FGRFGR 0.714 0.109 1 0.857
CAMK1ACAMK1A 0.714 -0.118 -3 0.231
PKN1PKN1 0.714 -0.121 -3 0.254
LOKLOK 0.713 -0.126 -2 0.586
TXKTXK 0.713 0.112 1 0.833
EPHB4EPHB4 0.712 0.044 -1 0.811
CRIKCRIK 0.712 -0.059 -3 0.259
SYKSYK 0.711 0.186 -1 0.808
EPHA6EPHA6 0.711 0.014 -1 0.854
YSK1YSK1 0.710 -0.108 2 0.755
ABL2ABL2 0.710 0.073 -1 0.788
FYNFYN 0.709 0.120 -1 0.816
ABL1ABL1 0.708 0.078 -1 0.779
PINK1_TYRPINK1_TYR 0.708 -0.092 1 0.838
BLKBLK 0.707 0.089 -1 0.822
LCKLCK 0.707 0.076 -1 0.825
FERFER 0.707 0.011 1 0.863
RIPK2RIPK2 0.706 -0.214 1 0.692
EPHA4EPHA4 0.706 0.009 2 0.740
PTK2PTK2 0.706 0.127 -1 0.813
MEK2MEK2 0.706 -0.244 2 0.756
ROCK1ROCK1 0.706 -0.088 -3 0.278
LIMK2_TYRLIMK2_TYR 0.705 -0.086 -3 0.319
YES1YES1 0.705 0.022 -1 0.810
FLT1FLT1 0.704 0.096 -1 0.838
ASK1ASK1 0.703 -0.098 1 0.720
HCKHCK 0.703 0.019 -1 0.811
SRMSSRMS 0.703 0.010 1 0.835
KITKIT 0.703 0.056 3 0.782
CSF1RCSF1R 0.703 0.015 3 0.774
RETRET 0.703 -0.069 1 0.782
METMET 0.702 0.082 3 0.776
BIKEBIKE 0.702 -0.010 1 0.782
INSRRINSRR 0.701 0.007 3 0.732
MYO3BMYO3B 0.701 -0.088 2 0.773
MST1RMST1R 0.701 -0.068 3 0.796
EPHB1EPHB1 0.700 -0.016 1 0.823
EPHB2EPHB2 0.700 0.007 -1 0.795
PKG1PKG1 0.699 -0.131 -2 0.403
MYO3AMYO3A 0.699 -0.080 1 0.763
BMXBMX 0.699 0.037 -1 0.714
JAK3JAK3 0.698 -0.027 1 0.763
ZAP70ZAP70 0.698 0.174 -1 0.730
KDRKDR 0.698 0.014 3 0.741
JAK2JAK2 0.698 -0.084 1 0.769
ITKITK 0.698 -0.008 -1 0.767
EPHB3EPHB3 0.697 -0.016 -1 0.793
ROS1ROS1 0.697 -0.084 3 0.745
LIMK1_TYRLIMK1_TYR 0.697 -0.191 2 0.788
TYRO3TYRO3 0.696 -0.092 3 0.771
TYK2TYK2 0.696 -0.150 1 0.775
SRCSRC 0.695 0.054 -1 0.804
TNK2TNK2 0.695 -0.029 3 0.746
NEK3NEK3 0.694 -0.215 1 0.728
FGFR2FGFR2 0.694 -0.054 3 0.794
MATKMATK 0.693 0.027 -1 0.729
DDR1DDR1 0.693 -0.155 4 0.805
ERBB2ERBB2 0.692 -0.001 1 0.744
LYNLYN 0.691 0.011 3 0.697
FGFR3FGFR3 0.691 -0.003 3 0.764
MERTKMERTK 0.691 -0.028 3 0.769
EPHA7EPHA7 0.691 -0.028 2 0.735
STLK3STLK3 0.690 -0.119 1 0.709
EPHA3EPHA3 0.690 -0.044 2 0.707
FLT3FLT3 0.690 -0.055 3 0.768
TAO1TAO1 0.690 -0.140 1 0.696
TECTEC 0.689 -0.044 -1 0.699
FGFR4FGFR4 0.689 0.031 -1 0.770
FRKFRK 0.689 -0.004 -1 0.814
EGFREGFR 0.689 0.012 1 0.649
EPHA5EPHA5 0.688 -0.006 2 0.724
WEE1_TYRWEE1_TYR 0.688 -0.038 -1 0.725
EPHA8EPHA8 0.688 -0.005 -1 0.803
ERBB4ERBB4 0.687 0.085 1 0.677
PTK2BPTK2B 0.686 -0.014 -1 0.735
BTKBTK 0.685 -0.109 -1 0.722
JAK1JAK1 0.684 -0.085 1 0.709
TEKTEK 0.684 -0.117 3 0.720
PTK6PTK6 0.684 -0.119 -1 0.708
CSKCSK 0.684 -0.012 2 0.732
NTRK1NTRK1 0.684 -0.105 -1 0.790
AAK1AAK1 0.683 0.012 1 0.697
FGFR1FGFR1 0.683 -0.111 3 0.753
PDGFRBPDGFRB 0.683 -0.147 3 0.782
NTRK3NTRK3 0.682 -0.064 -1 0.755
AXLAXL 0.681 -0.117 3 0.768
ALKALK 0.680 -0.109 3 0.698
FLT4FLT4 0.680 -0.079 3 0.739
LTKLTK 0.680 -0.110 3 0.727
INSRINSR 0.679 -0.074 3 0.707
TNK1TNK1 0.679 -0.139 3 0.759
NEK10_TYRNEK10_TYR 0.679 -0.146 1 0.663
EPHA2EPHA2 0.678 -0.019 -1 0.785
TNNI3K_TYRTNNI3K_TYR 0.677 -0.113 1 0.781
EPHA1EPHA1 0.677 -0.102 3 0.757
PDGFRAPDGFRA 0.676 -0.182 3 0.775
NTRK2NTRK2 0.675 -0.147 3 0.740
DDR2DDR2 0.674 -0.087 3 0.722
IGF1RIGF1R 0.671 -0.044 3 0.655
FESFES 0.668 -0.009 -1 0.698
MUSKMUSK 0.658 -0.124 1 0.653