Motif 272 (n=179)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0C4DFX4 | None | S2613 | ochoa | Snf2 related CREBBP activator protein | None |
A6NKD9 | CCDC85C | S216 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
A6NNA2 | SRRM3 | S333 | ochoa | Serine/arginine repetitive matrix protein 3 | May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). {ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:27748911}. |
O00273 | DFFA | S308 | ochoa | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
O00571 | DDX3X | S31 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
O14686 | KMT2D | S4328 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14733 | MAP2K7 | S58 | ochoa | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
O14920 | IKBKB | S675 | ochoa | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
O15049 | N4BP3 | S148 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
O15061 | SYNM | S1184 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
O15350 | TP73 | S426 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
O15533 | TAPBP | S359 | ochoa | Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) | Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848, ECO:0000269|PubMed:12582157, ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:26611325}. |
O43390 | HNRNPR | Y431 | ochoa | Heterogeneous nuclear ribonucleoprotein R (hnRNP R) | Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
O43566 | RGS14 | S45 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
O43741 | PRKAB2 | S177 | ochoa | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
O60239 | SH3BP5 | S354 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
O60716 | CTNND1 | S349 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
O60716 | CTNND1 | S352 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
O75044 | SRGAP2 | S799 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
O75064 | DENND4B | S1074 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
O75376 | NCOR1 | S2358 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
O75674 | TOM1L1 | S314 | ochoa | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}. |
O75886 | STAM2 | S375 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
O95208 | EPN2 | S479 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
O96005 | CLPTM1 | S27 | ochoa | Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1) | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}. |
O96013 | PAK4 | S97 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
P04350 | TUBB4A | S78 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P07437 | TUBB | S78 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P10398 | ARAF | S262 | psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
P11137 | MAP2 | S1611 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P14866 | HNRNPL | Y359 | psp | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
P15056 | BRAF | S394 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P16144 | ITGB4 | S1212 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
P17676 | CEBPB | S223 | ochoa|psp | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
P18887 | XRCC1 | S229 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
P19634 | SLC9A1 | S602 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
P22681 | CBL | S486 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
P26640 | VARS1 | S617 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
P27694 | RPA1 | S177 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
P27816 | MAP4 | S510 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
P38159 | RBMX | S88 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
P38159 | RBMX | S287 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
P42356 | PI4KA | S262 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
P46937 | YAP1 | S131 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
P49023 | PXN | S219 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
P49916 | LIG3 | S230 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
P56945 | BCAR1 | S440 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
P68371 | TUBB4B | S78 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P78559 | MAP1A | S1160 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
Q03111 | MLLT1 | S265 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
Q03164 | KMT2A | S3518 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q05397 | PTK2 | S705 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
Q06587 | RING1 | S190 | ochoa | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}. |
Q07820 | MCL1 | S67 | ochoa | Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. |
Q08174 | PCDH1 | S1014 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
Q08174 | PCDH1 | S1021 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
Q08378 | GOLGA3 | S21 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
Q10570 | CPSF1 | S756 | ochoa | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250|UniProtKB:A0A0R4IC37, ECO:0000269|PubMed:14749727}. |
Q12923 | PTPN13 | S217 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
Q13148 | TARDBP | S350 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
Q13393 | PLD1 | S522 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
Q13671 | RIN1 | S258 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
Q13796 | SHROOM2 | S977 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
Q13835 | PKP1 | S191 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
Q13885 | TUBB2A | S78 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14004 | CDK13 | S328 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Q14004 | CDK13 | S388 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
Q14160 | SCRIB | S1223 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14160 | SCRIB | S1298 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14185 | DOCK1 | S1761 | ochoa | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
Q14687 | GSE1 | S87 | ochoa | Genetic suppressor element 1 | None |
Q14802 | FXYD3 | S69 | ochoa | FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}. |
Q16594 | TAF9 | S152 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
Q4L180 | FILIP1L | S929 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
Q5T5Y3 | CAMSAP1 | S506 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
Q5TCX8 | MAP3K21 | S782 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
Q5TGY3 | AHDC1 | S1014 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
Q68EM7 | ARHGAP17 | S706 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
Q6IBW4 | NCAPH2 | S328 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
Q6IQ22 | RAB12 | S223 | ochoa | Ras-related protein Rab-12 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}. |
Q6P2E9 | EDC4 | S774 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6PJG2 | MIDEAS | S648 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
Q6WKZ4 | RAB11FIP1 | S392 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q6ZRS2 | SRCAP | S2790 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
Q6ZRV2 | FAM83H | S516 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
Q6ZTI6 | RFLNA | S28 | ochoa | Refilin-A (Regulator of filamin protein A) (RefilinA) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}. |
Q6ZTU2 | EP400P1 | S117 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
Q6ZUT6 | CCDC9B | S451 | ochoa | Coiled-coil domain-containing protein 9B | None |
Q70E73 | RAPH1 | S1069 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q7LBC6 | KDM3B | S730 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
Q7RTP6 | MICAL3 | S1450 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q86TI0 | TBC1D1 | S573 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
Q86TP1 | PRUNE1 | S396 | ochoa | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}. |
Q86UY5 | FAM83A | S353 | ochoa | Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) | Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}. |
Q86X10 | RALGAPB | S726 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
Q8IVJ1 | SLC41A1 | S76 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
Q8N6T3 | ARFGAP1 | S128 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
Q8N8E2 | ZNF513 | S99 | ochoa | Zinc finger protein 513 | Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}. |
Q8NAX2 | KDF1 | S160 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
Q8NC24 | RELL2 | S52 | ochoa | RELT-like protein 2 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
Q8NCG7 | DAGLB | S579 | ochoa | Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}. |
Q8NDT2 | RBM15B | S109 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
Q8NDT2 | RBM15B | S231 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
Q8NDT2 | RBM15B | S232 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
Q8NDT2 | RBM15B | S233 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
Q8NEZ4 | KMT2C | S2930 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q8NHM5 | KDM2B | S1018 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
Q8TBP0 | TBC1D16 | S263 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
Q8TCZ2 | CD99L2 | S244 | ochoa | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}. |
Q8TD16 | BICD2 | S611 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
Q8WWM7 | ATXN2L | S426 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
Q8WWM7 | ATXN2L | S597 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
Q92844 | TANK | S228 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
Q92997 | DVL3 | S642 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
Q969S8 | HDAC10 | S371 | ochoa | Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10) | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}. |
Q96AG3 | SLC25A46 | S37 | ochoa | Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) | Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}. |
Q96AP7 | ESAM | S315 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
Q96B33 | CLDN23 | S206 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
Q96CB8 | INTS12 | S353 | ochoa | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}. |
Q96D71 | REPS1 | S120 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
Q96D71 | REPS1 | S540 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
Q96E39 | RBMXL1 | S88 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
Q96E39 | RBMXL1 | S287 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
Q96HR8 | NAF1 | S34 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
Q96L91 | EP400 | S128 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Q96PU5 | NEDD4L | S184 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
Q96T58 | SPEN | S3436 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99759 | MAP3K3 | S169 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
Q9BQI5 | SGIP1 | S486 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
Q9BQK8 | LPIN3 | S224 | ochoa | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
Q9BRK4 | LZTS2 | S304 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
Q9BRK4 | LZTS2 | S305 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
Q9BRK4 | LZTS2 | S306 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
Q9BVA1 | TUBB2B | S78 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9BX66 | SORBS1 | S235 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
Q9C0B0 | UNK | S378 | ochoa|psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9C0B5 | ZDHHC5 | S305 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
Q9C0B5 | ZDHHC5 | S682 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
Q9C0C2 | TNKS1BP1 | S1141 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0K0 | BCL11B | S258 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9C0K0 | BCL11B | S401 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9H165 | BCL11A | S633 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
Q9H211 | CDT1 | S394 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
Q9H2G4 | TSPYL2 | S20 | ochoa|psp | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
Q9H3Q1 | CDC42EP4 | S315 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
Q9HC35 | EML4 | S891 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
Q9HCU4 | CELSR2 | S2668 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
Q9NQC7 | CYLD | S392 | ochoa | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
Q9NQV6 | PRDM10 | T823 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
Q9NR48 | ASH1L | S548 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
Q9P246 | STIM2 | S602 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
Q9P2G1 | ANKIB1 | S441 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9UBY9 | HSPB7 | S49 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
Q9UGP4 | LIMD1 | S387 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
Q9UGP4 | LIMD1 | S424 | ochoa|psp | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
Q9UHF7 | TRPS1 | S181 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
Q9UJM3 | ERRFI1 | S276 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
Q9ULH1 | ASAP1 | S782 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9ULH1 | ASAP1 | S785 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9ULH1 | ASAP1 | S819 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9ULH1 | ASAP1 | S820 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9UMN6 | KMT2B | S1890 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q9UPT8 | ZC3H4 | Y162 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
Q9UPW6 | SATB2 | S593 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
Q9UQ35 | SRRM2 | S300 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y2K6 | USP20 | S105 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
Q9Y2U8 | LEMD3 | S402 | ochoa|psp | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y3Q8 | TSC22D4 | S145 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
Q9Y3S1 | WNK2 | S1846 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Q9Y4F1 | FARP1 | S23 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
Q9Y4H2 | IRS2 | S645 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y4I1 | MYO5A | S603 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
Q9Y4U1 | MMACHC | S247 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
Q9Y5S2 | CDC42BPB | S1680 | ochoa|psp | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Q9Y6W5 | WASF2 | S292 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
Q9Y6W5 | WASF2 | S296 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
P23246 | SFPQ | Y251 | Sugiyama | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
Q06187 | BTK | S557 | Sugiyama | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
Q9UK32 | RPS6KA6 | S712 | Sugiyama | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.687125e-07 | 6.433 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.550732e-06 | 5.593 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 5.353829e-06 | 5.271 |
R-HSA-199991 | Membrane Trafficking | 5.143013e-06 | 5.289 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 6.627391e-06 | 5.179 |
R-HSA-4839726 | Chromatin organization | 1.059311e-05 | 4.975 |
R-HSA-438064 | Post NMDA receptor activation events | 1.329866e-05 | 4.876 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.995378e-05 | 4.700 |
R-HSA-437239 | Recycling pathway of L1 | 3.779950e-05 | 4.423 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.187062e-05 | 4.378 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 7.943332e-05 | 4.100 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 8.064498e-05 | 4.093 |
R-HSA-190861 | Gap junction assembly | 1.017437e-04 | 3.992 |
R-HSA-5653656 | Vesicle-mediated transport | 1.268818e-04 | 3.897 |
R-HSA-3247509 | Chromatin modifying enzymes | 1.336667e-04 | 3.874 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.853720e-04 | 3.732 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.049401e-04 | 3.688 |
R-HSA-6807878 | COPI-mediated anterograde transport | 2.049401e-04 | 3.688 |
R-HSA-9646399 | Aggrephagy | 1.910297e-04 | 3.719 |
R-HSA-3214841 | PKMTs methylate histone lysines | 2.103737e-04 | 3.677 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.624013e-04 | 3.581 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.673888e-04 | 3.573 |
R-HSA-190828 | Gap junction trafficking | 3.030435e-04 | 3.518 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.243943e-04 | 3.489 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.683567e-04 | 3.434 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.906955e-04 | 3.408 |
R-HSA-157858 | Gap junction trafficking and regulation | 4.589458e-04 | 3.338 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.711399e-04 | 3.327 |
R-HSA-9833482 | PKR-mediated signaling | 4.711399e-04 | 3.327 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.794926e-04 | 3.108 |
R-HSA-9663891 | Selective autophagy | 7.794926e-04 | 3.108 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.030480e-04 | 3.095 |
R-HSA-983189 | Kinesins | 1.006905e-03 | 2.997 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.143721e-03 | 2.942 |
R-HSA-8848021 | Signaling by PTK6 | 1.217071e-03 | 2.915 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.217071e-03 | 2.915 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.277926e-03 | 2.893 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.637109e-03 | 2.786 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.842439e-03 | 2.735 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.182574e-03 | 2.661 |
R-HSA-9700206 | Signaling by ALK in cancer | 2.182574e-03 | 2.661 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 2.189387e-03 | 2.660 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.369433e-03 | 2.625 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 2.507177e-03 | 2.601 |
R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 2.798205e-03 | 2.553 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.239514e-03 | 2.490 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.141228e-03 | 2.503 |
R-HSA-373760 | L1CAM interactions | 3.363034e-03 | 2.473 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.446337e-03 | 2.463 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.446337e-03 | 2.463 |
R-HSA-5620924 | Intraflagellar transport | 3.587871e-03 | 2.445 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.424019e-03 | 2.354 |
R-HSA-194138 | Signaling by VEGF | 4.799278e-03 | 2.319 |
R-HSA-162582 | Signal Transduction | 4.922137e-03 | 2.308 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 5.588735e-03 | 2.253 |
R-HSA-177929 | Signaling by EGFR | 5.721817e-03 | 2.242 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.831155e-03 | 2.234 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 6.713996e-03 | 2.173 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 6.713996e-03 | 2.173 |
R-HSA-9700645 | ALK mutants bind TKIs | 7.933103e-03 | 2.101 |
R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 7.933103e-03 | 2.101 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 7.933103e-03 | 2.101 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.785905e-03 | 2.109 |
R-HSA-1632852 | Macroautophagy | 8.451830e-03 | 2.073 |
R-HSA-5617833 | Cilium Assembly | 8.815923e-03 | 2.055 |
R-HSA-68877 | Mitotic Prometaphase | 9.481425e-03 | 2.023 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.028780e-02 | 1.988 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.151198e-02 | 1.939 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.169877e-02 | 1.932 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.242740e-02 | 1.906 |
R-HSA-9612973 | Autophagy | 1.308678e-02 | 1.883 |
R-HSA-69278 | Cell Cycle, Mitotic | 1.347793e-02 | 1.870 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 1.351608e-02 | 1.869 |
R-HSA-68886 | M Phase | 1.429553e-02 | 1.845 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.536189e-02 | 1.814 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.602519e-02 | 1.795 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.638696e-02 | 1.786 |
R-HSA-9675108 | Nervous system development | 1.645986e-02 | 1.784 |
R-HSA-418885 | DCC mediated attractive signaling | 1.891733e-02 | 1.723 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.891733e-02 | 1.723 |
R-HSA-1295596 | Spry regulation of FGF signaling | 1.891733e-02 | 1.723 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.734448e-02 | 1.761 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.891733e-02 | 1.723 |
R-HSA-2132295 | MHC class II antigen presentation | 1.834912e-02 | 1.736 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.979915e-02 | 1.703 |
R-HSA-9675151 | Disorders of Developmental Biology | 2.278286e-02 | 1.642 |
R-HSA-390466 | Chaperonin-mediated protein folding | 2.216581e-02 | 1.654 |
R-HSA-1483148 | Synthesis of PG | 2.278286e-02 | 1.642 |
R-HSA-75153 | Apoptotic execution phase | 2.225345e-02 | 1.653 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.363988e-02 | 1.626 |
R-HSA-422475 | Axon guidance | 2.329960e-02 | 1.633 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.107704e-02 | 1.676 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 2.143400e-02 | 1.669 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.482720e-02 | 1.605 |
R-HSA-381070 | IRE1alpha activates chaperones | 2.605284e-02 | 1.584 |
R-HSA-69275 | G2/M Transition | 2.664245e-02 | 1.574 |
R-HSA-391251 | Protein folding | 2.687626e-02 | 1.571 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.694347e-02 | 1.570 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.694347e-02 | 1.570 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 3.244044e-02 | 1.489 |
R-HSA-3359473 | Defective MMADHC causes MMAHCD | 3.244044e-02 | 1.489 |
R-HSA-5602636 | IKBKB deficiency causes SCID | 3.244044e-02 | 1.489 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.138466e-02 | 1.503 |
R-HSA-6807004 | Negative regulation of MET activity | 3.138466e-02 | 1.503 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.126256e-02 | 1.505 |
R-HSA-9664407 | Parasite infection | 3.054594e-02 | 1.515 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.054594e-02 | 1.515 |
R-HSA-9664417 | Leishmania phagocytosis | 3.054594e-02 | 1.515 |
R-HSA-453274 | Mitotic G2-G2/M phases | 2.774966e-02 | 1.557 |
R-HSA-8953897 | Cellular responses to stimuli | 3.228765e-02 | 1.491 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 2.983977e-02 | 1.525 |
R-HSA-9609690 | HCMV Early Events | 3.248185e-02 | 1.488 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.424896e-02 | 1.465 |
R-HSA-5610787 | Hedgehog 'off' state | 3.498743e-02 | 1.456 |
R-HSA-112315 | Transmission across Chemical Synapses | 3.690009e-02 | 1.433 |
R-HSA-350054 | Notch-HLH transcription pathway | 3.854196e-02 | 1.414 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.241077e-02 | 1.373 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.348384e-02 | 1.272 |
R-HSA-3359474 | Defective MMACHC causes MAHCC | 5.348384e-02 | 1.272 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.348384e-02 | 1.272 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.348384e-02 | 1.272 |
R-HSA-74713 | IRS activation | 7.407210e-02 | 1.130 |
R-HSA-9706377 | FLT3 signaling by CBL mutants | 7.407210e-02 | 1.130 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.419862e-02 | 1.075 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 8.419862e-02 | 1.075 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 9.421501e-02 | 1.026 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 9.421501e-02 | 1.026 |
R-HSA-112412 | SOS-mediated signalling | 1.041225e-01 | 0.982 |
R-HSA-446107 | Type I hemidesmosome assembly | 1.139221e-01 | 0.943 |
R-HSA-444257 | RSK activation | 1.139221e-01 | 0.943 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.139221e-01 | 0.943 |
R-HSA-201688 | WNT mediated activation of DVL | 1.236152e-01 | 0.908 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.332029e-01 | 0.875 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.520664e-01 | 0.818 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.520664e-01 | 0.818 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.613445e-01 | 0.792 |
R-HSA-9027284 | Erythropoietin activates RAS | 1.885775e-01 | 0.725 |
R-HSA-8964315 | G beta:gamma signalling through BTK | 1.885775e-01 | 0.725 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 6.920868e-02 | 1.160 |
R-HSA-5656121 | Translesion synthesis by POLI | 1.974583e-01 | 0.705 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.974583e-01 | 0.705 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.062424e-01 | 0.686 |
R-HSA-5655862 | Translesion synthesis by POLK | 2.062424e-01 | 0.686 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 8.507168e-02 | 1.070 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.427147e-02 | 1.354 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.427147e-02 | 1.354 |
R-HSA-8854518 | AURKA Activation by TPX2 | 4.896567e-02 | 1.310 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.081823e-02 | 1.216 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.195589e-01 | 0.922 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 1.195589e-01 | 0.922 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.195589e-01 | 0.922 |
R-HSA-380287 | Centrosome maturation | 6.442929e-02 | 1.191 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.919074e-01 | 0.717 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.078272e-01 | 0.682 |
R-HSA-182971 | EGFR downregulation | 6.317070e-02 | 1.199 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 2.081799e-01 | 0.682 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 9.665305e-02 | 1.015 |
R-HSA-9656223 | Signaling by RAF1 mutants | 1.019043e-01 | 0.992 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.004502e-01 | 0.698 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.004502e-01 | 0.698 |
R-HSA-5674135 | MAP2K and MAPK activation | 1.019043e-01 | 0.992 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.004502e-01 | 0.698 |
R-HSA-9762292 | Regulation of CDH11 function | 1.332029e-01 | 0.875 |
R-HSA-198203 | PI3K/AKT activation | 1.332029e-01 | 0.875 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.426862e-01 | 0.846 |
R-HSA-110312 | Translesion synthesis by REV1 | 1.885775e-01 | 0.725 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.185235e-02 | 1.087 |
R-HSA-6802949 | Signaling by RAS mutants | 1.195589e-01 | 0.922 |
R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.236152e-01 | 0.908 |
R-HSA-9796292 | Formation of axial mesoderm | 1.705217e-01 | 0.768 |
R-HSA-69166 | Removal of the Flap Intermediate | 1.795990e-01 | 0.746 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.062424e-01 | 0.686 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.149310e-01 | 0.668 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.520664e-01 | 0.818 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.062424e-01 | 0.686 |
R-HSA-68962 | Activation of the pre-replicative complex | 6.022294e-02 | 1.220 |
R-HSA-9664420 | Killing mechanisms | 1.974583e-01 | 0.705 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.974583e-01 | 0.705 |
R-HSA-5673000 | RAF activation | 7.542750e-02 | 1.122 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 1.365815e-01 | 0.865 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.365815e-01 | 0.865 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.332029e-01 | 0.875 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.846751e-02 | 1.007 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.795990e-01 | 0.746 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.974583e-01 | 0.705 |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 4.301965e-02 | 1.366 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.419862e-02 | 1.075 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.332029e-01 | 0.875 |
R-HSA-209560 | NF-kB is activated and signals survival | 1.520664e-01 | 0.818 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 5.447696e-02 | 1.264 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.705217e-01 | 0.768 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 5.732455e-02 | 1.242 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.885775e-01 | 0.725 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 7.542750e-02 | 1.122 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.147873e-01 | 0.940 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 6.920868e-02 | 1.160 |
R-HSA-170968 | Frs2-mediated activation | 1.705217e-01 | 0.768 |
R-HSA-212165 | Epigenetic regulation of gene expression | 1.781061e-01 | 0.749 |
R-HSA-74749 | Signal attenuation | 1.332029e-01 | 0.875 |
R-HSA-69183 | Processive synthesis on the lagging strand | 1.885775e-01 | 0.725 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 9.506467e-02 | 1.022 |
R-HSA-5260271 | Diseases of Immune System | 9.506467e-02 | 1.022 |
R-HSA-169893 | Prolonged ERK activation events | 1.974583e-01 | 0.705 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.442929e-02 | 1.191 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.041225e-01 | 0.982 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 5.168164e-02 | 1.287 |
R-HSA-3214815 | HDACs deacetylate histones | 1.529854e-01 | 0.815 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.810965e-01 | 0.742 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 1.195589e-01 | 0.922 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 1.606450e-01 | 0.794 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.810965e-01 | 0.742 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.893283e-01 | 0.723 |
R-HSA-5696398 | Nucleotide Excision Repair | 1.390860e-01 | 0.857 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.893283e-01 | 0.723 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.116999e-01 | 0.952 |
R-HSA-1236974 | ER-Phagosome pathway | 9.447540e-02 | 1.025 |
R-HSA-68875 | Mitotic Prophase | 1.838295e-01 | 0.736 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.185235e-02 | 1.087 |
R-HSA-75893 | TNF signaling | 1.568062e-01 | 0.805 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.518374e-01 | 0.819 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 8.419862e-02 | 1.075 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 8.419862e-02 | 1.075 |
R-HSA-170984 | ARMS-mediated activation | 1.236152e-01 | 0.908 |
R-HSA-426048 | Arachidonate production from DAG | 1.332029e-01 | 0.875 |
R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.520664e-01 | 0.818 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.885775e-01 | 0.725 |
R-HSA-354192 | Integrin signaling | 6.920868e-02 | 1.160 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.062424e-01 | 0.686 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.185235e-02 | 1.087 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 1.518374e-01 | 0.819 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.390860e-01 | 0.857 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.159689e-01 | 0.936 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 1.019043e-01 | 0.992 |
R-HSA-373752 | Netrin-1 signaling | 1.124073e-01 | 0.949 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 5.447696e-02 | 1.264 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.795990e-01 | 0.746 |
R-HSA-5693538 | Homology Directed Repair | 1.783747e-01 | 0.749 |
R-HSA-168898 | Toll-like Receptor Cascades | 2.014036e-01 | 0.696 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.139221e-01 | 0.943 |
R-HSA-425986 | Sodium/Proton exchangers | 1.139221e-01 | 0.943 |
R-HSA-428540 | Activation of RAC1 | 1.520664e-01 | 0.818 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.613445e-01 | 0.792 |
R-HSA-937039 | IRAK1 recruits IKK complex | 1.613445e-01 | 0.792 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.795990e-01 | 0.746 |
R-HSA-9706369 | Negative regulation of FLT3 | 1.974583e-01 | 0.705 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 9.169696e-02 | 1.038 |
R-HSA-445355 | Smooth Muscle Contraction | 1.454016e-01 | 0.837 |
R-HSA-2467813 | Separation of Sister Chromatids | 5.167209e-02 | 1.287 |
R-HSA-3214842 | HDMs demethylate histones | 4.625375e-02 | 1.335 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 9.506467e-02 | 1.022 |
R-HSA-2028269 | Signaling by Hippo | 2.149310e-01 | 0.668 |
R-HSA-193639 | p75NTR signals via NF-kB | 1.885775e-01 | 0.725 |
R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.149310e-01 | 0.668 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.896567e-02 | 1.310 |
R-HSA-8941326 | RUNX2 regulates bone development | 8.181655e-02 | 1.087 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.419862e-02 | 1.075 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.419862e-02 | 1.075 |
R-HSA-9613354 | Lipophagy | 1.236152e-01 | 0.908 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.426862e-01 | 0.846 |
R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 1.426862e-01 | 0.846 |
R-HSA-9005895 | Pervasive developmental disorders | 1.613445e-01 | 0.792 |
R-HSA-9697154 | Disorders of Nervous System Development | 1.613445e-01 | 0.792 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.613445e-01 | 0.792 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.705217e-01 | 0.768 |
R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.149310e-01 | 0.668 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.683734e-01 | 0.774 |
R-HSA-6806834 | Signaling by MET | 7.387695e-02 | 1.131 |
R-HSA-2559583 | Cellular Senescence | 6.992808e-02 | 1.155 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.101386e-01 | 0.958 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6.616641e-02 | 1.179 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.159689e-01 | 0.936 |
R-HSA-446652 | Interleukin-1 family signaling | 1.189660e-01 | 0.925 |
R-HSA-5654743 | Signaling by FGFR4 | 1.088754e-01 | 0.963 |
R-HSA-9658195 | Leishmania infection | 1.162134e-01 | 0.935 |
R-HSA-9824443 | Parasitic Infection Pathways | 1.162134e-01 | 0.935 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 8.419862e-02 | 1.075 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.149310e-01 | 0.668 |
R-HSA-5654741 | Signaling by FGFR3 | 1.159689e-01 | 0.936 |
R-HSA-1236975 | Antigen processing-Cross presentation | 1.466922e-01 | 0.834 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.625375e-02 | 1.335 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.625375e-02 | 1.335 |
R-HSA-5654736 | Signaling by FGFR1 | 1.568062e-01 | 0.805 |
R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 7.407210e-02 | 1.130 |
R-HSA-9635465 | Suppression of apoptosis | 1.426862e-01 | 0.846 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.597400e-02 | 1.066 |
R-HSA-73884 | Base Excision Repair | 9.665305e-02 | 1.015 |
R-HSA-1640170 | Cell Cycle | 5.998160e-02 | 1.222 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.088754e-01 | 0.963 |
R-HSA-69206 | G1/S Transition | 2.004502e-01 | 0.698 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.920937e-01 | 0.716 |
R-HSA-1433559 | Regulation of KIT signaling | 1.795990e-01 | 0.746 |
R-HSA-450294 | MAP kinase activation | 1.761641e-01 | 0.754 |
R-HSA-68882 | Mitotic Anaphase | 4.730384e-02 | 1.325 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.809889e-02 | 1.318 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.974583e-01 | 0.705 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 1.340928e-01 | 0.873 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 8.806746e-02 | 1.055 |
R-HSA-9007101 | Rab regulation of trafficking | 5.757742e-02 | 1.240 |
R-HSA-448424 | Interleukin-17 signaling | 2.118295e-01 | 0.674 |
R-HSA-209543 | p75NTR recruits signalling complexes | 1.613445e-01 | 0.792 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 7.542750e-02 | 1.122 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.171392e-01 | 0.931 |
R-HSA-2586552 | Signaling by Leptin | 1.332029e-01 | 0.875 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.139221e-01 | 0.943 |
R-HSA-391160 | Signal regulatory protein family interactions | 1.795990e-01 | 0.746 |
R-HSA-446353 | Cell-extracellular matrix interactions | 1.885775e-01 | 0.725 |
R-HSA-1266738 | Developmental Biology | 6.176483e-02 | 1.209 |
R-HSA-112316 | Neuronal System | 1.723379e-01 | 0.764 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.622965e-01 | 0.790 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.568062e-01 | 0.805 |
R-HSA-9609646 | HCMV Infection | 7.900588e-02 | 1.102 |
R-HSA-2262752 | Cellular responses to stress | 6.620586e-02 | 1.179 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.602272e-01 | 0.795 |
R-HSA-109581 | Apoptosis | 1.379909e-01 | 0.860 |
R-HSA-9008059 | Interleukin-37 signaling | 6.022294e-02 | 1.220 |
R-HSA-69205 | G1/S-Specific Transcription | 8.181655e-02 | 1.087 |
R-HSA-425410 | Metal ion SLC transporters | 1.268202e-01 | 0.897 |
R-HSA-1643685 | Disease | 2.060532e-01 | 0.686 |
R-HSA-1483166 | Synthesis of PA | 1.606450e-01 | 0.794 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.149310e-01 | 0.668 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.149310e-01 | 0.668 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.304895e-01 | 0.884 |
R-HSA-9856651 | MITF-M-dependent gene expression | 1.153075e-01 | 0.938 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.616641e-02 | 1.179 |
R-HSA-5633007 | Regulation of TP53 Activity | 1.340912e-01 | 0.873 |
R-HSA-1059683 | Interleukin-6 signaling | 1.705217e-01 | 0.768 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 2.149310e-01 | 0.668 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.722613e-01 | 0.764 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.722613e-01 | 0.764 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.722613e-01 | 0.764 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.722613e-01 | 0.764 |
R-HSA-5663205 | Infectious disease | 1.827324e-01 | 0.738 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.879532e-01 | 0.726 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.268202e-01 | 0.897 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.722613e-01 | 0.764 |
R-HSA-5358351 | Signaling by Hedgehog | 9.280359e-02 | 1.032 |
R-HSA-446203 | Asparagine N-linked glycosylation | 2.167057e-01 | 0.664 |
R-HSA-9843745 | Adipogenesis | 2.202686e-01 | 0.657 |
R-HSA-389948 | Co-inhibition by PD-1 | 2.219248e-01 | 0.654 |
R-HSA-168256 | Immune System | 2.225077e-01 | 0.653 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.235249e-01 | 0.651 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.235249e-01 | 0.651 |
R-HSA-5358508 | Mismatch Repair | 2.235249e-01 | 0.651 |
R-HSA-180292 | GAB1 signalosome | 2.235249e-01 | 0.651 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.279085e-01 | 0.642 |
R-HSA-1236394 | Signaling by ERBB4 | 2.279085e-01 | 0.642 |
R-HSA-912631 | Regulation of signaling by CBL | 2.320254e-01 | 0.634 |
R-HSA-110320 | Translesion Synthesis by POLH | 2.320254e-01 | 0.634 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.320254e-01 | 0.634 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.320254e-01 | 0.634 |
R-HSA-72172 | mRNA Splicing | 2.335586e-01 | 0.632 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.337315e-01 | 0.631 |
R-HSA-5357801 | Programmed Cell Death | 2.359034e-01 | 0.627 |
R-HSA-1980143 | Signaling by NOTCH1 | 2.359812e-01 | 0.627 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.404332e-01 | 0.619 |
R-HSA-4086400 | PCP/CE pathway | 2.440698e-01 | 0.612 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.487496e-01 | 0.604 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.487496e-01 | 0.604 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.487496e-01 | 0.604 |
R-HSA-69186 | Lagging Strand Synthesis | 2.487496e-01 | 0.604 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.487496e-01 | 0.604 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.487496e-01 | 0.604 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.487496e-01 | 0.604 |
R-HSA-5654738 | Signaling by FGFR2 | 2.521698e-01 | 0.598 |
R-HSA-5673001 | RAF/MAP kinase cascade | 2.540608e-01 | 0.595 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.548572e-01 | 0.594 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.569754e-01 | 0.590 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.569754e-01 | 0.590 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.569754e-01 | 0.590 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.569754e-01 | 0.590 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.569754e-01 | 0.590 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.602769e-01 | 0.585 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.651116e-01 | 0.577 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.651116e-01 | 0.577 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.651116e-01 | 0.577 |
R-HSA-1483257 | Phospholipid metabolism | 2.664661e-01 | 0.574 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.685472e-01 | 0.571 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.698136e-01 | 0.569 |
R-HSA-6802957 | Oncogenic MAPK signaling | 2.724418e-01 | 0.565 |
R-HSA-109582 | Hemostasis | 2.726816e-01 | 0.564 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.731592e-01 | 0.564 |
R-HSA-200425 | Carnitine shuttle | 2.731592e-01 | 0.564 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.731592e-01 | 0.564 |
R-HSA-3000170 | Syndecan interactions | 2.731592e-01 | 0.564 |
R-HSA-982772 | Growth hormone receptor signaling | 2.731592e-01 | 0.564 |
R-HSA-6798695 | Neutrophil degranulation | 2.740862e-01 | 0.562 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.805490e-01 | 0.552 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.811192e-01 | 0.551 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.811192e-01 | 0.551 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.811192e-01 | 0.551 |
R-HSA-429947 | Deadenylation of mRNA | 2.811192e-01 | 0.551 |
R-HSA-6783589 | Interleukin-6 family signaling | 2.811192e-01 | 0.551 |
R-HSA-449147 | Signaling by Interleukins | 2.816471e-01 | 0.550 |
R-HSA-9679191 | Potential therapeutics for SARS | 2.816710e-01 | 0.550 |
R-HSA-1280218 | Adaptive Immune System | 2.855248e-01 | 0.544 |
R-HSA-913531 | Interferon Signaling | 2.857449e-01 | 0.544 |
R-HSA-9620244 | Long-term potentiation | 2.889925e-01 | 0.539 |
R-HSA-420029 | Tight junction interactions | 2.889925e-01 | 0.539 |
R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.889925e-01 | 0.539 |
R-HSA-2160916 | Hyaluronan degradation | 2.889925e-01 | 0.539 |
R-HSA-3000157 | Laminin interactions | 2.889925e-01 | 0.539 |
R-HSA-1266695 | Interleukin-7 signaling | 2.889925e-01 | 0.539 |
R-HSA-69306 | DNA Replication | 2.905956e-01 | 0.537 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 2.905956e-01 | 0.537 |
R-HSA-8874081 | MET activates PTK2 signaling | 2.967801e-01 | 0.528 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.967801e-01 | 0.528 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.967801e-01 | 0.528 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 2.967801e-01 | 0.528 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.967801e-01 | 0.528 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.044829e-01 | 0.516 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.044829e-01 | 0.516 |
R-HSA-9759218 | Cobalamin (Cbl) metabolism | 3.044829e-01 | 0.516 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.044829e-01 | 0.516 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.044829e-01 | 0.516 |
R-HSA-75109 | Triglyceride biosynthesis | 3.044829e-01 | 0.516 |
R-HSA-1483213 | Synthesis of PE | 3.044829e-01 | 0.516 |
R-HSA-264876 | Insulin processing | 3.044829e-01 | 0.516 |
R-HSA-1500931 | Cell-Cell communication | 3.108378e-01 | 0.507 |
R-HSA-9006936 | Signaling by TGFB family members | 3.114910e-01 | 0.507 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.121017e-01 | 0.506 |
R-HSA-168249 | Innate Immune System | 3.154980e-01 | 0.501 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 3.185638e-01 | 0.497 |
R-HSA-9006335 | Signaling by Erythropoietin | 3.196376e-01 | 0.495 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.196376e-01 | 0.495 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 3.196376e-01 | 0.495 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.196376e-01 | 0.495 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.196376e-01 | 0.495 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.270913e-01 | 0.485 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.270913e-01 | 0.485 |
R-HSA-2424491 | DAP12 signaling | 3.270913e-01 | 0.485 |
R-HSA-114452 | Activation of BH3-only proteins | 3.270913e-01 | 0.485 |
R-HSA-162588 | Budding and maturation of HIV virion | 3.344639e-01 | 0.476 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.344639e-01 | 0.476 |
R-HSA-186763 | Downstream signal transduction | 3.344639e-01 | 0.476 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.369283e-01 | 0.472 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.369283e-01 | 0.472 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.369283e-01 | 0.472 |
R-HSA-190236 | Signaling by FGFR | 3.369283e-01 | 0.472 |
R-HSA-3214847 | HATs acetylate histones | 3.409140e-01 | 0.467 |
R-HSA-69190 | DNA strand elongation | 3.417561e-01 | 0.466 |
R-HSA-9020702 | Interleukin-1 signaling | 3.488631e-01 | 0.457 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.489689e-01 | 0.457 |
R-HSA-176187 | Activation of ATR in response to replication stress | 3.489689e-01 | 0.457 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.489689e-01 | 0.457 |
R-HSA-9930044 | Nuclear RNA decay | 3.489689e-01 | 0.457 |
R-HSA-397795 | G-protein beta:gamma signalling | 3.489689e-01 | 0.457 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.489689e-01 | 0.457 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.489689e-01 | 0.457 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.528258e-01 | 0.452 |
R-HSA-1483255 | PI Metabolism | 3.528258e-01 | 0.452 |
R-HSA-5689880 | Ub-specific processing proteases | 3.533561e-01 | 0.452 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 3.561031e-01 | 0.448 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.561031e-01 | 0.448 |
R-HSA-5688426 | Deubiquitination | 3.578987e-01 | 0.446 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.603825e-01 | 0.443 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.607261e-01 | 0.443 |
R-HSA-5696400 | Dual Incision in GG-NER | 3.631595e-01 | 0.440 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.631595e-01 | 0.440 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.631595e-01 | 0.440 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.631595e-01 | 0.440 |
R-HSA-2142845 | Hyaluronan metabolism | 3.631595e-01 | 0.440 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.631595e-01 | 0.440 |
R-HSA-187687 | Signalling to ERKs | 3.701391e-01 | 0.432 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.701391e-01 | 0.432 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.701391e-01 | 0.432 |
R-HSA-381042 | PERK regulates gene expression | 3.701391e-01 | 0.432 |
R-HSA-69239 | Synthesis of DNA | 3.764180e-01 | 0.424 |
R-HSA-3371511 | HSF1 activation | 3.770425e-01 | 0.424 |
R-HSA-8853659 | RET signaling | 3.770425e-01 | 0.424 |
R-HSA-9682385 | FLT3 signaling in disease | 3.770425e-01 | 0.424 |
R-HSA-5683057 | MAPK family signaling cascades | 3.778675e-01 | 0.423 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.803168e-01 | 0.420 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.803168e-01 | 0.420 |
R-HSA-2672351 | Stimuli-sensing channels | 3.803168e-01 | 0.420 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.838708e-01 | 0.416 |
R-HSA-4641258 | Degradation of DVL | 3.838708e-01 | 0.416 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.838708e-01 | 0.416 |
R-HSA-5689896 | Ovarian tumor domain proteases | 3.838708e-01 | 0.416 |
R-HSA-69002 | DNA Replication Pre-Initiation | 3.842054e-01 | 0.415 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.842054e-01 | 0.415 |
R-HSA-8875878 | MET promotes cell motility | 3.906246e-01 | 0.408 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.906246e-01 | 0.408 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.973048e-01 | 0.401 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.973048e-01 | 0.401 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.973048e-01 | 0.401 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.996532e-01 | 0.398 |
R-HSA-983712 | Ion channel transport | 4.008128e-01 | 0.397 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.039121e-01 | 0.394 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.039121e-01 | 0.394 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.039121e-01 | 0.394 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.104475e-01 | 0.387 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.104475e-01 | 0.387 |
R-HSA-9694548 | Maturation of spike protein | 4.104475e-01 | 0.387 |
R-HSA-9607240 | FLT3 Signaling | 4.104475e-01 | 0.387 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.104475e-01 | 0.387 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.111209e-01 | 0.386 |
R-HSA-446728 | Cell junction organization | 4.148185e-01 | 0.382 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.149198e-01 | 0.382 |
R-HSA-167161 | HIV Transcription Initiation | 4.169116e-01 | 0.380 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.169116e-01 | 0.380 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.169116e-01 | 0.380 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 4.169116e-01 | 0.380 |
R-HSA-1592230 | Mitochondrial biogenesis | 4.224810e-01 | 0.374 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.233052e-01 | 0.373 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.233052e-01 | 0.373 |
R-HSA-165159 | MTOR signalling | 4.233052e-01 | 0.373 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.233052e-01 | 0.373 |
R-HSA-73857 | RNA Polymerase II Transcription | 4.249190e-01 | 0.372 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.296291e-01 | 0.367 |
R-HSA-8854214 | TBC/RABGAPs | 4.296291e-01 | 0.367 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 4.296291e-01 | 0.367 |
R-HSA-1433557 | Signaling by SCF-KIT | 4.296291e-01 | 0.367 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.299920e-01 | 0.367 |
R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.358840e-01 | 0.361 |
R-HSA-2172127 | DAP12 interactions | 4.358840e-01 | 0.361 |
R-HSA-3928662 | EPHB-mediated forward signaling | 4.358840e-01 | 0.361 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.415411e-01 | 0.355 |
R-HSA-376176 | Signaling by ROBO receptors | 4.415411e-01 | 0.355 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 4.415411e-01 | 0.355 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.420707e-01 | 0.355 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.420707e-01 | 0.355 |
R-HSA-6783310 | Fanconi Anemia Pathway | 4.420707e-01 | 0.355 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.447245e-01 | 0.352 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.481900e-01 | 0.349 |
R-HSA-9675135 | Diseases of DNA repair | 4.481900e-01 | 0.349 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.542425e-01 | 0.343 |
R-HSA-1483191 | Synthesis of PC | 4.542425e-01 | 0.343 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.576643e-01 | 0.339 |
R-HSA-73893 | DNA Damage Bypass | 4.661502e-01 | 0.331 |
R-HSA-9766229 | Degradation of CDH1 | 4.661502e-01 | 0.331 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.667501e-01 | 0.331 |
R-HSA-397014 | Muscle contraction | 4.699811e-01 | 0.328 |
R-HSA-109704 | PI3K Cascade | 4.720068e-01 | 0.326 |
R-HSA-9824439 | Bacterial Infection Pathways | 4.725004e-01 | 0.326 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.777995e-01 | 0.321 |
R-HSA-912446 | Meiotic recombination | 4.777995e-01 | 0.321 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.777995e-01 | 0.321 |
R-HSA-72187 | mRNA 3'-end processing | 4.835290e-01 | 0.316 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.835290e-01 | 0.316 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.835290e-01 | 0.316 |
R-HSA-68949 | Orc1 removal from chromatin | 4.835290e-01 | 0.316 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.835290e-01 | 0.316 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.835290e-01 | 0.316 |
R-HSA-9909396 | Circadian clock | 4.846007e-01 | 0.315 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.891960e-01 | 0.311 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.891960e-01 | 0.311 |
R-HSA-9824446 | Viral Infection Pathways | 4.969817e-01 | 0.304 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.020794e-01 | 0.299 |
R-HSA-5578775 | Ion homeostasis | 5.058287e-01 | 0.296 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.058287e-01 | 0.296 |
R-HSA-112399 | IRS-mediated signalling | 5.112524e-01 | 0.291 |
R-HSA-9764561 | Regulation of CDH1 Function | 5.112524e-01 | 0.291 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.112524e-01 | 0.291 |
R-HSA-6782135 | Dual incision in TC-NER | 5.166168e-01 | 0.287 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.166168e-01 | 0.287 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 5.166168e-01 | 0.287 |
R-HSA-180786 | Extension of Telomeres | 5.219228e-01 | 0.282 |
R-HSA-8979227 | Triglyceride metabolism | 5.219228e-01 | 0.282 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.219228e-01 | 0.282 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 5.259037e-01 | 0.279 |
R-HSA-8873719 | RAB geranylgeranylation | 5.271708e-01 | 0.278 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 5.271708e-01 | 0.278 |
R-HSA-379724 | tRNA Aminoacylation | 5.271708e-01 | 0.278 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.323615e-01 | 0.274 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.323615e-01 | 0.274 |
R-HSA-9707616 | Heme signaling | 5.374955e-01 | 0.270 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 5.374955e-01 | 0.270 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.374955e-01 | 0.270 |
R-HSA-6784531 | tRNA processing in the nucleus | 5.374955e-01 | 0.270 |
R-HSA-186797 | Signaling by PDGF | 5.374955e-01 | 0.270 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.374955e-01 | 0.270 |
R-HSA-69242 | S Phase | 5.457084e-01 | 0.263 |
R-HSA-166520 | Signaling by NTRKs | 5.457084e-01 | 0.263 |
R-HSA-74751 | Insulin receptor signalling cascade | 5.475961e-01 | 0.262 |
R-HSA-2428924 | IGF1R signaling cascade | 5.475961e-01 | 0.262 |
R-HSA-936837 | Ion transport by P-type ATPases | 5.475961e-01 | 0.262 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.525638e-01 | 0.258 |
R-HSA-1234174 | Cellular response to hypoxia | 5.525638e-01 | 0.258 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.585897e-01 | 0.253 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.623371e-01 | 0.250 |
R-HSA-73887 | Death Receptor Signaling | 5.649329e-01 | 0.248 |
R-HSA-212436 | Generic Transcription Pathway | 5.662548e-01 | 0.247 |
R-HSA-167172 | Transcription of the HIV genome | 5.671439e-01 | 0.246 |
R-HSA-162587 | HIV Life Cycle | 5.743254e-01 | 0.241 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.766004e-01 | 0.239 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.766004e-01 | 0.239 |
R-HSA-9711097 | Cellular response to starvation | 5.774235e-01 | 0.239 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.774235e-01 | 0.239 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.812514e-01 | 0.236 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.812514e-01 | 0.236 |
R-HSA-69052 | Switching of origins to a post-replicative state | 5.904015e-01 | 0.229 |
R-HSA-69473 | G2/M DNA damage checkpoint | 5.949017e-01 | 0.226 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.993527e-01 | 0.222 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.993527e-01 | 0.222 |
R-HSA-9734767 | Developmental Cell Lineages | 6.032647e-01 | 0.219 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.037551e-01 | 0.219 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 6.081094e-01 | 0.216 |
R-HSA-9694635 | Translation of Structural Proteins | 6.081094e-01 | 0.216 |
R-HSA-73864 | RNA Polymerase I Transcription | 6.124161e-01 | 0.213 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 6.124161e-01 | 0.213 |
R-HSA-416482 | G alpha (12/13) signalling events | 6.124161e-01 | 0.213 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.124161e-01 | 0.213 |
R-HSA-74160 | Gene expression (Transcription) | 6.130791e-01 | 0.212 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.208888e-01 | 0.207 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 6.250559e-01 | 0.204 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.250559e-01 | 0.204 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 6.289870e-01 | 0.201 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.291774e-01 | 0.201 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 6.332538e-01 | 0.198 |
R-HSA-1500620 | Meiosis | 6.412735e-01 | 0.193 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.452178e-01 | 0.190 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 6.522149e-01 | 0.186 |
R-HSA-202424 | Downstream TCR signaling | 6.643013e-01 | 0.178 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.679937e-01 | 0.175 |
R-HSA-74752 | Signaling by Insulin receptor | 6.752577e-01 | 0.171 |
R-HSA-2682334 | EPH-Ephrin signaling | 6.752577e-01 | 0.171 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.752577e-01 | 0.171 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.755458e-01 | 0.170 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.788303e-01 | 0.168 |
R-HSA-68867 | Assembly of the pre-replicative complex | 6.788303e-01 | 0.168 |
R-HSA-195721 | Signaling by WNT | 6.810595e-01 | 0.167 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.823638e-01 | 0.166 |
R-HSA-1474290 | Collagen formation | 6.823638e-01 | 0.166 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.927339e-01 | 0.159 |
R-HSA-157579 | Telomere Maintenance | 6.961152e-01 | 0.157 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.961152e-01 | 0.157 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.027673e-01 | 0.153 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.092746e-01 | 0.149 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.124749e-01 | 0.147 |
R-HSA-8953854 | Metabolism of RNA | 7.287734e-01 | 0.137 |
R-HSA-202403 | TCR signaling | 7.397462e-01 | 0.131 |
R-HSA-2871796 | FCERI mediated MAPK activation | 7.454481e-01 | 0.128 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.510258e-01 | 0.124 |
R-HSA-162906 | HIV Infection | 7.564199e-01 | 0.121 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.564820e-01 | 0.121 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.591653e-01 | 0.120 |
R-HSA-9679506 | SARS-CoV Infections | 7.618919e-01 | 0.118 |
R-HSA-2980736 | Peptide hormone metabolism | 7.644441e-01 | 0.117 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.670402e-01 | 0.115 |
R-HSA-73886 | Chromosome Maintenance | 7.746589e-01 | 0.111 |
R-HSA-3371556 | Cellular response to heat stress | 7.746589e-01 | 0.111 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.746589e-01 | 0.111 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 7.755784e-01 | 0.110 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.795999e-01 | 0.108 |
R-HSA-157118 | Signaling by NOTCH | 7.810651e-01 | 0.107 |
R-HSA-6809371 | Formation of the cornified envelope | 7.820299e-01 | 0.107 |
R-HSA-73894 | DNA Repair | 7.901532e-01 | 0.102 |
R-HSA-69481 | G2/M Checkpoints | 7.914861e-01 | 0.102 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.983096e-01 | 0.098 |
R-HSA-421270 | Cell-cell junction organization | 8.001938e-01 | 0.097 |
R-HSA-1474165 | Reproduction | 8.005344e-01 | 0.097 |
R-HSA-5576891 | Cardiac conduction | 8.027348e-01 | 0.095 |
R-HSA-163685 | Integration of energy metabolism | 8.154393e-01 | 0.089 |
R-HSA-416476 | G alpha (q) signalling events | 8.208890e-01 | 0.086 |
R-HSA-6807070 | PTEN Regulation | 8.214830e-01 | 0.085 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.292362e-01 | 0.081 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 8.329863e-01 | 0.079 |
R-HSA-597592 | Post-translational protein modification | 8.352107e-01 | 0.078 |
R-HSA-9758941 | Gastrulation | 8.420071e-01 | 0.075 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.463850e-01 | 0.072 |
R-HSA-1989781 | PPARA activates gene expression | 8.521947e-01 | 0.069 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.554433e-01 | 0.068 |
R-HSA-1257604 | PIP3 activates AKT signaling | 8.627104e-01 | 0.064 |
R-HSA-72306 | tRNA processing | 8.762790e-01 | 0.057 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.776475e-01 | 0.057 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.803395e-01 | 0.055 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.803395e-01 | 0.055 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 9.042222e-01 | 0.044 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.073700e-01 | 0.042 |
R-HSA-9006925 | Intracellular signaling by second messengers | 9.093704e-01 | 0.041 |
R-HSA-9694516 | SARS-CoV-2 Infection | 9.149010e-01 | 0.039 |
R-HSA-6805567 | Keratinization | 9.180569e-01 | 0.037 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 9.250298e-01 | 0.034 |
R-HSA-418990 | Adherens junctions interactions | 9.283211e-01 | 0.032 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 9.358904e-01 | 0.029 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.373060e-01 | 0.028 |
R-HSA-8939211 | ESR-mediated signaling | 9.420203e-01 | 0.026 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.456217e-01 | 0.024 |
R-HSA-69620 | Cell Cycle Checkpoints | 9.541504e-01 | 0.020 |
R-HSA-9711123 | Cellular response to chemical stress | 9.590036e-01 | 0.018 |
R-HSA-1474244 | Extracellular matrix organization | 9.797737e-01 | 0.009 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.860457e-01 | 0.006 |
R-HSA-382551 | Transport of small molecules | 9.871778e-01 | 0.006 |
R-HSA-392499 | Metabolism of proteins | 9.878894e-01 | 0.005 |
R-HSA-418594 | G alpha (i) signalling events | 9.915036e-01 | 0.004 |
R-HSA-8978868 | Fatty acid metabolism | 9.915036e-01 | 0.004 |
R-HSA-5668914 | Diseases of metabolism | 9.932222e-01 | 0.003 |
R-HSA-388396 | GPCR downstream signalling | 9.933050e-01 | 0.003 |
R-HSA-72766 | Translation | 9.933737e-01 | 0.003 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.950628e-01 | 0.002 |
R-HSA-372790 | Signaling by GPCR | 9.969130e-01 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 9.980942e-01 | 0.001 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CK1E |
0.833 | 0.555 | -3 | 0.727 |
CK1D |
0.832 | 0.558 | -3 | 0.733 |
CK1A2 |
0.824 | 0.536 | -3 | 0.733 |
KIS |
0.822 | 0.262 | 1 | 0.816 |
CK1G1 |
0.811 | 0.469 | -3 | 0.710 |
GRK1 |
0.809 | 0.274 | -2 | 0.735 |
CK1A |
0.809 | 0.482 | -3 | 0.731 |
COT |
0.807 | 0.145 | 2 | 0.830 |
CLK3 |
0.806 | 0.165 | 1 | 0.916 |
CDC7 |
0.802 | 0.138 | 1 | 0.852 |
MOS |
0.801 | 0.171 | 1 | 0.883 |
MTOR |
0.797 | 0.111 | 1 | 0.819 |
ERK5 |
0.795 | 0.141 | 1 | 0.895 |
HIPK4 |
0.795 | 0.143 | 1 | 0.869 |
GRK7 |
0.795 | 0.211 | 1 | 0.784 |
CDKL1 |
0.794 | 0.078 | -3 | 0.313 |
IKKB |
0.794 | 0.052 | -2 | 0.625 |
CDKL5 |
0.793 | 0.112 | -3 | 0.299 |
GRK5 |
0.792 | 0.191 | -3 | 0.459 |
PIM3 |
0.790 | 0.021 | -3 | 0.344 |
DYRK2 |
0.790 | 0.145 | 1 | 0.822 |
P38B |
0.789 | 0.228 | 1 | 0.781 |
PRPK |
0.789 | 0.004 | -1 | 0.832 |
BMPR1B |
0.789 | 0.168 | 1 | 0.814 |
CDK1 |
0.789 | 0.179 | 1 | 0.782 |
NLK |
0.788 | 0.103 | 1 | 0.901 |
GRK6 |
0.788 | 0.209 | 1 | 0.829 |
CDK8 |
0.788 | 0.160 | 1 | 0.794 |
CDK19 |
0.787 | 0.171 | 1 | 0.764 |
SRPK1 |
0.786 | 0.032 | -3 | 0.304 |
ATR |
0.786 | 0.054 | 1 | 0.845 |
NDR2 |
0.786 | 0.002 | -3 | 0.336 |
HIPK2 |
0.786 | 0.164 | 1 | 0.753 |
ICK |
0.785 | 0.137 | -3 | 0.328 |
GRK4 |
0.785 | 0.172 | -2 | 0.716 |
ERK1 |
0.785 | 0.204 | 1 | 0.769 |
CDK18 |
0.785 | 0.180 | 1 | 0.759 |
RAF1 |
0.785 | 0.004 | 1 | 0.820 |
P38D |
0.784 | 0.206 | 1 | 0.721 |
JNK3 |
0.784 | 0.169 | 1 | 0.788 |
DSTYK |
0.784 | -0.019 | 2 | 0.835 |
P38A |
0.784 | 0.212 | 1 | 0.838 |
IKKA |
0.783 | 0.042 | -2 | 0.641 |
JNK2 |
0.783 | 0.176 | 1 | 0.756 |
GRK3 |
0.781 | 0.192 | -2 | 0.608 |
CK1G3 |
0.781 | 0.454 | -3 | 0.721 |
P38G |
0.780 | 0.175 | 1 | 0.704 |
PDHK4 |
0.780 | -0.120 | 1 | 0.845 |
MLK1 |
0.780 | 0.096 | 2 | 0.765 |
SKMLCK |
0.779 | 0.003 | -2 | 0.691 |
GRK2 |
0.779 | 0.143 | -2 | 0.634 |
CAMK2G |
0.779 | -0.031 | 2 | 0.755 |
TBK1 |
0.779 | -0.011 | 1 | 0.701 |
CLK2 |
0.778 | 0.078 | -3 | 0.301 |
BMPR2 |
0.778 | -0.048 | -2 | 0.715 |
DYRK4 |
0.778 | 0.143 | 1 | 0.766 |
CHAK2 |
0.777 | 0.038 | -1 | 0.778 |
HIPK1 |
0.777 | 0.122 | 1 | 0.834 |
IKKE |
0.776 | -0.038 | 1 | 0.695 |
RIPK3 |
0.776 | 0.033 | 3 | 0.738 |
PIM1 |
0.776 | 0.003 | -3 | 0.334 |
SRPK3 |
0.776 | 0.010 | -3 | 0.304 |
CAMK1B |
0.776 | -0.082 | -3 | 0.339 |
MAK |
0.776 | 0.213 | -2 | 0.833 |
CDK7 |
0.775 | 0.124 | 1 | 0.812 |
SRPK2 |
0.775 | -0.001 | -3 | 0.263 |
RSK2 |
0.774 | -0.044 | -3 | 0.284 |
CDK17 |
0.774 | 0.154 | 1 | 0.712 |
FAM20C |
0.774 | 0.036 | 2 | 0.536 |
DYRK1A |
0.773 | 0.107 | 1 | 0.844 |
GCN2 |
0.773 | -0.124 | 2 | 0.753 |
CDK5 |
0.773 | 0.139 | 1 | 0.832 |
DLK |
0.772 | 0.081 | 1 | 0.811 |
PRP4 |
0.772 | 0.063 | -3 | 0.318 |
NUAK2 |
0.771 | -0.050 | -3 | 0.339 |
CDK13 |
0.770 | 0.103 | 1 | 0.787 |
JNK1 |
0.770 | 0.156 | 1 | 0.753 |
MLK3 |
0.770 | 0.048 | 2 | 0.691 |
NEK6 |
0.770 | -0.092 | -2 | 0.675 |
ERK2 |
0.769 | 0.147 | 1 | 0.804 |
WNK1 |
0.769 | -0.049 | -2 | 0.731 |
NIK |
0.768 | -0.099 | -3 | 0.348 |
ACVR2B |
0.768 | 0.068 | -2 | 0.627 |
CK1G2 |
0.768 | 0.388 | -3 | 0.719 |
MST4 |
0.768 | -0.032 | 2 | 0.804 |
PRKD1 |
0.768 | -0.071 | -3 | 0.281 |
DAPK2 |
0.768 | -0.077 | -3 | 0.335 |
CDK14 |
0.768 | 0.140 | 1 | 0.791 |
PDHK1 |
0.768 | -0.192 | 1 | 0.817 |
ATM |
0.768 | 0.015 | 1 | 0.782 |
P90RSK |
0.768 | -0.065 | -3 | 0.282 |
ALK4 |
0.767 | 0.020 | -2 | 0.669 |
MAPKAPK2 |
0.767 | -0.061 | -3 | 0.258 |
CAMLCK |
0.767 | -0.081 | -2 | 0.660 |
NDR1 |
0.767 | -0.083 | -3 | 0.320 |
CLK4 |
0.767 | 0.009 | -3 | 0.313 |
PASK |
0.767 | 0.095 | -3 | 0.370 |
BMPR1A |
0.767 | 0.108 | 1 | 0.786 |
TGFBR1 |
0.767 | 0.009 | -2 | 0.646 |
TTBK2 |
0.766 | -0.002 | 2 | 0.635 |
NEK7 |
0.766 | -0.129 | -3 | 0.340 |
CDK16 |
0.766 | 0.151 | 1 | 0.728 |
RSK4 |
0.765 | -0.022 | -3 | 0.283 |
ACVR2A |
0.765 | 0.066 | -2 | 0.606 |
PKN2 |
0.765 | -0.067 | -3 | 0.335 |
PRKX |
0.765 | -0.023 | -3 | 0.277 |
CDK3 |
0.765 | 0.123 | 1 | 0.731 |
PRKD2 |
0.765 | -0.074 | -3 | 0.260 |
MASTL |
0.765 | -0.122 | -2 | 0.669 |
PKN3 |
0.765 | -0.093 | -3 | 0.309 |
DYRK1B |
0.764 | 0.096 | 1 | 0.795 |
BCKDK |
0.764 | -0.103 | -1 | 0.741 |
ULK2 |
0.764 | -0.188 | 2 | 0.727 |
MARK4 |
0.764 | -0.081 | 4 | 0.809 |
P70S6KB |
0.764 | -0.075 | -3 | 0.295 |
MLK4 |
0.764 | 0.080 | 2 | 0.676 |
GSK3A |
0.764 | 0.109 | 4 | 0.550 |
MLK2 |
0.763 | -0.025 | 2 | 0.763 |
PKACG |
0.763 | -0.061 | -2 | 0.549 |
LATS1 |
0.763 | -0.015 | -3 | 0.325 |
HUNK |
0.763 | -0.115 | 2 | 0.767 |
AURC |
0.763 | -0.036 | -2 | 0.471 |
CDK12 |
0.763 | 0.098 | 1 | 0.761 |
MPSK1 |
0.763 | 0.159 | 1 | 0.823 |
MEKK3 |
0.763 | 0.151 | 1 | 0.782 |
TGFBR2 |
0.762 | -0.100 | -2 | 0.614 |
ALK2 |
0.762 | 0.033 | -2 | 0.662 |
AMPKA1 |
0.762 | -0.080 | -3 | 0.330 |
CDK10 |
0.762 | 0.122 | 1 | 0.781 |
RIPK1 |
0.762 | -0.062 | 1 | 0.788 |
PKACB |
0.762 | -0.041 | -2 | 0.471 |
LATS2 |
0.761 | -0.077 | -5 | 0.740 |
CAMK2A |
0.761 | -0.037 | 2 | 0.753 |
HIPK3 |
0.761 | 0.079 | 1 | 0.816 |
RSK3 |
0.761 | -0.088 | -3 | 0.267 |
DYRK3 |
0.761 | 0.058 | 1 | 0.825 |
SMG1 |
0.760 | -0.010 | 1 | 0.799 |
CAMK2B |
0.760 | -0.041 | 2 | 0.728 |
CLK1 |
0.760 | -0.005 | -3 | 0.277 |
ANKRD3 |
0.759 | -0.088 | 1 | 0.830 |
CAMK2D |
0.759 | -0.120 | -3 | 0.300 |
MAPKAPK3 |
0.759 | -0.122 | -3 | 0.263 |
CK2A2 |
0.759 | 0.097 | 1 | 0.733 |
IRE1 |
0.759 | -0.024 | 1 | 0.791 |
CDK2 |
0.758 | 0.059 | 1 | 0.839 |
MEK1 |
0.758 | 0.024 | 2 | 0.794 |
ULK1 |
0.758 | -0.172 | -3 | 0.311 |
MSK1 |
0.758 | -0.057 | -3 | 0.283 |
YSK4 |
0.758 | -0.036 | 1 | 0.750 |
AMPKA2 |
0.758 | -0.080 | -3 | 0.306 |
MSK2 |
0.757 | -0.087 | -3 | 0.296 |
PKR |
0.757 | -0.017 | 1 | 0.834 |
GSK3B |
0.757 | 0.071 | 4 | 0.543 |
WNK3 |
0.756 | -0.167 | 1 | 0.795 |
NEK9 |
0.756 | -0.143 | 2 | 0.779 |
AKT2 |
0.756 | -0.054 | -3 | 0.265 |
PLK1 |
0.756 | -0.073 | -2 | 0.608 |
TLK2 |
0.755 | -0.019 | 1 | 0.788 |
PAK1 |
0.755 | -0.078 | -2 | 0.615 |
VRK2 |
0.755 | -0.079 | 1 | 0.870 |
CDK9 |
0.755 | 0.063 | 1 | 0.791 |
DNAPK |
0.755 | 0.007 | 1 | 0.719 |
GAK |
0.754 | 0.160 | 1 | 0.881 |
PKCD |
0.754 | -0.079 | 2 | 0.737 |
MYLK4 |
0.754 | -0.058 | -2 | 0.570 |
CK2A1 |
0.753 | 0.108 | 1 | 0.711 |
MST3 |
0.753 | 0.073 | 2 | 0.800 |
QSK |
0.753 | -0.065 | 4 | 0.780 |
MOK |
0.753 | 0.135 | 1 | 0.847 |
PKCB |
0.752 | -0.051 | 2 | 0.692 |
PIM2 |
0.752 | -0.045 | -3 | 0.273 |
TSSK2 |
0.752 | -0.096 | -5 | 0.832 |
PKCG |
0.752 | -0.046 | 2 | 0.689 |
NIM1 |
0.752 | -0.108 | 3 | 0.765 |
CAMK4 |
0.751 | -0.140 | -3 | 0.322 |
DRAK1 |
0.750 | -0.030 | 1 | 0.767 |
MEKK2 |
0.750 | 0.071 | 2 | 0.744 |
PKCA |
0.750 | -0.044 | 2 | 0.685 |
TSSK1 |
0.749 | -0.098 | -3 | 0.328 |
SGK3 |
0.749 | -0.075 | -3 | 0.284 |
AURA |
0.749 | -0.052 | -2 | 0.437 |
ERK7 |
0.749 | 0.074 | 2 | 0.559 |
TLK1 |
0.748 | -0.002 | -2 | 0.667 |
PRKD3 |
0.748 | -0.105 | -3 | 0.262 |
QIK |
0.748 | -0.130 | -3 | 0.317 |
MARK3 |
0.748 | -0.059 | 4 | 0.740 |
PLK3 |
0.747 | -0.090 | 2 | 0.727 |
PAK3 |
0.747 | -0.122 | -2 | 0.595 |
MEK5 |
0.747 | -0.051 | 2 | 0.772 |
TAO3 |
0.747 | 0.015 | 1 | 0.784 |
AURB |
0.747 | -0.072 | -2 | 0.462 |
SIK |
0.746 | -0.097 | -3 | 0.284 |
PAK2 |
0.745 | -0.097 | -2 | 0.596 |
NUAK1 |
0.745 | -0.124 | -3 | 0.280 |
BRSK1 |
0.745 | -0.108 | -3 | 0.286 |
PKCZ |
0.745 | -0.070 | 2 | 0.734 |
PINK1 |
0.745 | -0.118 | 1 | 0.878 |
PKG2 |
0.743 | -0.090 | -2 | 0.486 |
IRE2 |
0.743 | -0.084 | 2 | 0.702 |
MELK |
0.743 | -0.150 | -3 | 0.279 |
BRAF |
0.742 | -0.106 | -4 | 0.806 |
NEK11 |
0.742 | 0.000 | 1 | 0.770 |
YANK3 |
0.742 | 0.123 | 2 | 0.368 |
CHAK1 |
0.742 | -0.112 | 2 | 0.718 |
MNK1 |
0.742 | -0.100 | -2 | 0.595 |
PKACA |
0.742 | -0.075 | -2 | 0.423 |
ZAK |
0.742 | -0.053 | 1 | 0.743 |
PLK2 |
0.741 | -0.018 | -3 | 0.327 |
CAMK1G |
0.741 | -0.107 | -3 | 0.283 |
MNK2 |
0.741 | -0.120 | -2 | 0.583 |
PHKG1 |
0.741 | -0.119 | -3 | 0.320 |
GCK |
0.741 | 0.042 | 1 | 0.793 |
PKCH |
0.740 | -0.101 | 2 | 0.673 |
MARK2 |
0.740 | -0.090 | 4 | 0.697 |
PERK |
0.740 | -0.114 | -2 | 0.670 |
NEK5 |
0.740 | -0.095 | 1 | 0.818 |
MEKK1 |
0.740 | -0.099 | 1 | 0.780 |
CDK6 |
0.740 | 0.093 | 1 | 0.771 |
NEK2 |
0.739 | -0.172 | 2 | 0.766 |
MAPKAPK5 |
0.739 | -0.162 | -3 | 0.244 |
AKT1 |
0.738 | -0.075 | -3 | 0.266 |
LKB1 |
0.738 | -0.055 | -3 | 0.311 |
TAK1 |
0.738 | 0.055 | 1 | 0.801 |
WNK4 |
0.738 | -0.098 | -2 | 0.733 |
BRSK2 |
0.738 | -0.139 | -3 | 0.291 |
MARK1 |
0.738 | -0.106 | 4 | 0.755 |
PAK6 |
0.737 | -0.106 | -2 | 0.512 |
DAPK3 |
0.737 | -0.060 | -3 | 0.321 |
DAPK1 |
0.737 | -0.043 | -3 | 0.328 |
DCAMKL1 |
0.737 | -0.125 | -3 | 0.291 |
CAMKK1 |
0.737 | -0.103 | -2 | 0.640 |
SGK1 |
0.736 | -0.053 | -3 | 0.233 |
TTBK1 |
0.736 | -0.068 | 2 | 0.555 |
SMMLCK |
0.736 | -0.108 | -3 | 0.308 |
P70S6K |
0.736 | -0.098 | -3 | 0.243 |
PLK4 |
0.736 | -0.105 | 2 | 0.589 |
CHK1 |
0.734 | -0.171 | -3 | 0.260 |
HPK1 |
0.734 | 0.017 | 1 | 0.772 |
CAMKK2 |
0.733 | -0.105 | -2 | 0.635 |
CDK4 |
0.733 | 0.084 | 1 | 0.752 |
NEK8 |
0.733 | -0.083 | 2 | 0.770 |
MST2 |
0.733 | -0.034 | 1 | 0.789 |
EEF2K |
0.733 | 0.008 | 3 | 0.779 |
HRI |
0.733 | -0.192 | -2 | 0.659 |
IRAK4 |
0.732 | -0.102 | 1 | 0.779 |
SNRK |
0.732 | -0.204 | 2 | 0.650 |
AKT3 |
0.731 | -0.065 | -3 | 0.241 |
ALPHAK3 |
0.731 | 0.128 | -1 | 0.771 |
PDK1 |
0.730 | -0.081 | 1 | 0.769 |
PDHK3_TYR |
0.730 | 0.153 | 4 | 0.892 |
PDHK1_TYR |
0.729 | 0.233 | -1 | 0.864 |
PDHK4_TYR |
0.729 | 0.218 | 2 | 0.843 |
MAP3K15 |
0.729 | -0.030 | 1 | 0.735 |
MINK |
0.729 | -0.021 | 1 | 0.767 |
MAP2K6_TYR |
0.728 | 0.229 | -1 | 0.846 |
TAO2 |
0.727 | -0.109 | 2 | 0.791 |
PKCE |
0.727 | -0.061 | 2 | 0.676 |
CAMK1D |
0.727 | -0.121 | -3 | 0.237 |
LRRK2 |
0.727 | -0.095 | 2 | 0.799 |
BMPR2_TYR |
0.727 | 0.117 | -1 | 0.868 |
SSTK |
0.726 | -0.100 | 4 | 0.766 |
SBK |
0.726 | -0.065 | -3 | 0.196 |
MAP2K4_TYR |
0.726 | 0.143 | -1 | 0.847 |
TNIK |
0.726 | -0.046 | 3 | 0.817 |
PBK |
0.726 | 0.009 | 1 | 0.818 |
MEKK6 |
0.725 | -0.094 | 1 | 0.786 |
DCAMKL2 |
0.725 | -0.145 | -3 | 0.290 |
CHK2 |
0.724 | -0.100 | -3 | 0.231 |
KHS2 |
0.724 | 0.009 | 1 | 0.778 |
PKCT |
0.724 | -0.121 | 2 | 0.679 |
PKCI |
0.723 | -0.099 | 2 | 0.706 |
VRK1 |
0.723 | -0.087 | 2 | 0.792 |
NEK4 |
0.723 | -0.135 | 1 | 0.768 |
HGK |
0.723 | -0.079 | 3 | 0.820 |
ROCK2 |
0.722 | -0.062 | -3 | 0.303 |
BUB1 |
0.722 | -0.017 | -5 | 0.791 |
SLK |
0.721 | -0.063 | -2 | 0.566 |
KHS1 |
0.721 | -0.030 | 1 | 0.759 |
YANK2 |
0.720 | 0.143 | 2 | 0.376 |
MRCKA |
0.720 | -0.088 | -3 | 0.277 |
IRAK1 |
0.720 | -0.208 | -1 | 0.688 |
MST1 |
0.719 | -0.090 | 1 | 0.768 |
PAK5 |
0.719 | -0.121 | -2 | 0.462 |
DMPK1 |
0.719 | -0.053 | -3 | 0.298 |
PHKG2 |
0.719 | -0.155 | -3 | 0.295 |
MRCKB |
0.719 | -0.090 | -3 | 0.271 |
OSR1 |
0.719 | 0.002 | 2 | 0.756 |
TTK |
0.718 | 0.024 | -2 | 0.637 |
TESK1_TYR |
0.716 | -0.027 | 3 | 0.863 |
NEK1 |
0.716 | -0.168 | 1 | 0.779 |
PKMYT1_TYR |
0.715 | -0.021 | 3 | 0.838 |
HASPIN |
0.715 | 0.009 | -1 | 0.659 |
PAK4 |
0.715 | -0.112 | -2 | 0.466 |
STK33 |
0.715 | -0.107 | 2 | 0.565 |
MAP2K7_TYR |
0.714 | -0.051 | 2 | 0.804 |
FGR |
0.714 | 0.109 | 1 | 0.857 |
CAMK1A |
0.714 | -0.118 | -3 | 0.231 |
PKN1 |
0.714 | -0.121 | -3 | 0.254 |
LOK |
0.713 | -0.126 | -2 | 0.586 |
TXK |
0.713 | 0.112 | 1 | 0.833 |
EPHB4 |
0.712 | 0.044 | -1 | 0.811 |
CRIK |
0.712 | -0.059 | -3 | 0.259 |
SYK |
0.711 | 0.186 | -1 | 0.808 |
EPHA6 |
0.711 | 0.014 | -1 | 0.854 |
YSK1 |
0.710 | -0.108 | 2 | 0.755 |
ABL2 |
0.710 | 0.073 | -1 | 0.788 |
FYN |
0.709 | 0.120 | -1 | 0.816 |
ABL1 |
0.708 | 0.078 | -1 | 0.779 |
PINK1_TYR |
0.708 | -0.092 | 1 | 0.838 |
BLK |
0.707 | 0.089 | -1 | 0.822 |
LCK |
0.707 | 0.076 | -1 | 0.825 |
FER |
0.707 | 0.011 | 1 | 0.863 |
RIPK2 |
0.706 | -0.214 | 1 | 0.692 |
EPHA4 |
0.706 | 0.009 | 2 | 0.740 |
PTK2 |
0.706 | 0.127 | -1 | 0.813 |
MEK2 |
0.706 | -0.244 | 2 | 0.756 |
ROCK1 |
0.706 | -0.088 | -3 | 0.278 |
LIMK2_TYR |
0.705 | -0.086 | -3 | 0.319 |
YES1 |
0.705 | 0.022 | -1 | 0.810 |
FLT1 |
0.704 | 0.096 | -1 | 0.838 |
ASK1 |
0.703 | -0.098 | 1 | 0.720 |
HCK |
0.703 | 0.019 | -1 | 0.811 |
SRMS |
0.703 | 0.010 | 1 | 0.835 |
KIT |
0.703 | 0.056 | 3 | 0.782 |
CSF1R |
0.703 | 0.015 | 3 | 0.774 |
RET |
0.703 | -0.069 | 1 | 0.782 |
MET |
0.702 | 0.082 | 3 | 0.776 |
BIKE |
0.702 | -0.010 | 1 | 0.782 |
INSRR |
0.701 | 0.007 | 3 | 0.732 |
MYO3B |
0.701 | -0.088 | 2 | 0.773 |
MST1R |
0.701 | -0.068 | 3 | 0.796 |
EPHB1 |
0.700 | -0.016 | 1 | 0.823 |
EPHB2 |
0.700 | 0.007 | -1 | 0.795 |
PKG1 |
0.699 | -0.131 | -2 | 0.403 |
MYO3A |
0.699 | -0.080 | 1 | 0.763 |
BMX |
0.699 | 0.037 | -1 | 0.714 |
JAK3 |
0.698 | -0.027 | 1 | 0.763 |
ZAP70 |
0.698 | 0.174 | -1 | 0.730 |
KDR |
0.698 | 0.014 | 3 | 0.741 |
JAK2 |
0.698 | -0.084 | 1 | 0.769 |
ITK |
0.698 | -0.008 | -1 | 0.767 |
EPHB3 |
0.697 | -0.016 | -1 | 0.793 |
ROS1 |
0.697 | -0.084 | 3 | 0.745 |
LIMK1_TYR |
0.697 | -0.191 | 2 | 0.788 |
TYRO3 |
0.696 | -0.092 | 3 | 0.771 |
TYK2 |
0.696 | -0.150 | 1 | 0.775 |
SRC |
0.695 | 0.054 | -1 | 0.804 |
TNK2 |
0.695 | -0.029 | 3 | 0.746 |
NEK3 |
0.694 | -0.215 | 1 | 0.728 |
FGFR2 |
0.694 | -0.054 | 3 | 0.794 |
MATK |
0.693 | 0.027 | -1 | 0.729 |
DDR1 |
0.693 | -0.155 | 4 | 0.805 |
ERBB2 |
0.692 | -0.001 | 1 | 0.744 |
LYN |
0.691 | 0.011 | 3 | 0.697 |
FGFR3 |
0.691 | -0.003 | 3 | 0.764 |
MERTK |
0.691 | -0.028 | 3 | 0.769 |
EPHA7 |
0.691 | -0.028 | 2 | 0.735 |
STLK3 |
0.690 | -0.119 | 1 | 0.709 |
EPHA3 |
0.690 | -0.044 | 2 | 0.707 |
FLT3 |
0.690 | -0.055 | 3 | 0.768 |
TAO1 |
0.690 | -0.140 | 1 | 0.696 |
TEC |
0.689 | -0.044 | -1 | 0.699 |
FGFR4 |
0.689 | 0.031 | -1 | 0.770 |
FRK |
0.689 | -0.004 | -1 | 0.814 |
EGFR |
0.689 | 0.012 | 1 | 0.649 |
EPHA5 |
0.688 | -0.006 | 2 | 0.724 |
WEE1_TYR |
0.688 | -0.038 | -1 | 0.725 |
EPHA8 |
0.688 | -0.005 | -1 | 0.803 |
ERBB4 |
0.687 | 0.085 | 1 | 0.677 |
PTK2B |
0.686 | -0.014 | -1 | 0.735 |
BTK |
0.685 | -0.109 | -1 | 0.722 |
JAK1 |
0.684 | -0.085 | 1 | 0.709 |
TEK |
0.684 | -0.117 | 3 | 0.720 |
PTK6 |
0.684 | -0.119 | -1 | 0.708 |
CSK |
0.684 | -0.012 | 2 | 0.732 |
NTRK1 |
0.684 | -0.105 | -1 | 0.790 |
AAK1 |
0.683 | 0.012 | 1 | 0.697 |
FGFR1 |
0.683 | -0.111 | 3 | 0.753 |
PDGFRB |
0.683 | -0.147 | 3 | 0.782 |
NTRK3 |
0.682 | -0.064 | -1 | 0.755 |
AXL |
0.681 | -0.117 | 3 | 0.768 |
ALK |
0.680 | -0.109 | 3 | 0.698 |
FLT4 |
0.680 | -0.079 | 3 | 0.739 |
LTK |
0.680 | -0.110 | 3 | 0.727 |
INSR |
0.679 | -0.074 | 3 | 0.707 |
TNK1 |
0.679 | -0.139 | 3 | 0.759 |
NEK10_TYR |
0.679 | -0.146 | 1 | 0.663 |
EPHA2 |
0.678 | -0.019 | -1 | 0.785 |
TNNI3K_TYR |
0.677 | -0.113 | 1 | 0.781 |
EPHA1 |
0.677 | -0.102 | 3 | 0.757 |
PDGFRA |
0.676 | -0.182 | 3 | 0.775 |
NTRK2 |
0.675 | -0.147 | 3 | 0.740 |
DDR2 |
0.674 | -0.087 | 3 | 0.722 |
IGF1R |
0.671 | -0.044 | 3 | 0.655 |
FES |
0.668 | -0.009 | -1 | 0.698 |
MUSK |
0.658 | -0.124 | 1 | 0.653 |