Motif 268 (n=160)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0C4DFX4 None S2613 ochoa Snf2 related CREBBP activator protein None
A6NEL2 SOWAHB S106 ochoa Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) None
A6NHT5 HMX3 S144 ochoa Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}.
A6NIX2 WTIP S29 ochoa Wilms tumor protein 1-interacting protein (WT1-interacting protein) Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
A6NKD9 CCDC85C S216 ochoa Coiled-coil domain-containing protein 85C May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.
A6NNZ2 TUBB8B S278 ochoa Tubulin beta 8B Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
E7EW31 PROB1 S218 ochoa Proline-rich basic protein 1 None
E9PAV3 NACA S917 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
E9PAV3 NACA S1388 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
M0R1B8 None S36 ochoa Uncharacterized protein None
O00221 NFKBIE S183 ochoa NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}.
O00267 SUPT5H S797 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O14686 KMT2D S48 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O15061 SYNM S1049 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O15394 NCAM2 S786 ochoa Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
O43166 SIPA1L1 S1078 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43426 SYNJ1 S1178 ochoa Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}.
O43593 HR S416 ochoa Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.
O43593 HR S833 ochoa Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.
O43683 BUB1 S331 ochoa|psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O43815 STRN S376 ochoa Striatin Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}.
O60496 DOK2 S269 ochoa Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
O60496 DOK2 S282 ochoa Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
O75145 PPFIA3 S512 ochoa Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.
O75369 FLNB S1028 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O94989 ARHGEF15 S90 ochoa Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.
O95180 CACNA1H S758 ochoa Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.
P01106 MYC S77 psp Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.
P04350 TUBB4A S278 ochoa Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P07437 TUBB S278 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P10398 ARAF S165 ochoa Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P10636 MAPT S552 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11137 MAP2 S654 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P14866 HNRNPL S298 ochoa Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
P15408 FOSL2 S194 ochoa Fos-related antigen 2 (FRA-2) Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}.
P15976 GATA1 S178 psp Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}.
P19793 RXRA S21 ochoa|psp Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:1310260, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:25417649, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:29021580, ECO:0000269|PubMed:30216632, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}.
P21333 FLNA S2494 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P35611 ADD1 S358 ochoa|psp Alpha-adducin (Erythrocyte adducin subunit alpha) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
P35680 HNF1B S334 ochoa Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1) Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:17924661, PubMed:7900999). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). {ECO:0000250|UniProtKB:Q03365, ECO:0000269|PubMed:17924661, ECO:0000269|PubMed:24204001, ECO:0000269|PubMed:7900999}.
P41212 ETV6 S22 ochoa|psp Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.
P43243 MATR3 S276 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P48637 GSS S415 ochoa Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}.
P50406 HTR6 S350 psp 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6) G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:8522988}.
P51531 SMARCA2 S329 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51608 MECP2 S164 ochoa|psp Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P51617 IRAK1 S173 psp Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P54259 ATN1 S661 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P68371 TUBB4B S278 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q08174 PCDH1 S962 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q10586 DBP S156 ochoa D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Q12830 BPTF S216 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q13322 GRB10 S150 ochoa|psp Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.
Q13469 NFATC2 S73 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13627 DYRK1A S555 ochoa Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}.
Q13885 TUBB2A S278 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14157 UBAP2L S454 ochoa|psp Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14315 FLNC S1050 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14774 HLX S91 ochoa H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.
Q15717 ELAVL1 S202 ochoa|psp ELAV-like protein 1 (Hu-antigen R) (HuR) RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}.
Q16665 HIF1A S451 ochoa|psp Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}.
Q2KHM9 KIAA0753 S190 ochoa Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.
Q3ZCM7 TUBB8 S278 ochoa Tubulin beta-8 chain (Tubulin beta 8 class VIII) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}.
Q53GS9 USP39 S46 ochoa Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}.
Q58EX7 PLEKHG4 S64 ochoa Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Q5JTC6 AMER1 S286 ochoa APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Q5JTD0 TJAP1 S491 ochoa Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}.
Q5SXM2 SNAPC4 S1224 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5T7B8 KIF24 S997 ochoa Kinesin-like protein KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.
Q641Q2 WASHC2A S1008 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q68EM7 ARHGAP17 S561 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6DN90 IQSEC1 S417 ochoa IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}.
Q6EKJ0 GTF2IRD2B S205 ochoa General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) None
Q6IN85 PPP4R3A S771 ochoa Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
Q6P0Q8 MAST2 S191 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P474 PDXDC2P S400 ochoa Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC 4.1.1.-) (pyridoxal-dependent decarboxylase domain-containing 2 pseudogene) None
Q6P996 PDXDC1 S401 ochoa Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) None
Q6UB99 ANKRD11 S1891 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6ZRI6 C15orf39 S116 ochoa Uncharacterized protein C15orf39 None
Q6ZRS2 SRCAP S2790 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q7RTP6 MICAL3 S1384 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z2Z1 TICRR S1433 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z7G8 VPS13B S1263 ochoa Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}.
Q86TI0 TBC1D1 S695 ochoa TBC1 domain family member 1 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86UP8 GTF2IRD2 S205 ochoa General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) None
Q86UU1 PHLDB1 S461 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UY5 FAM83A S357 ochoa Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein) Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}.
Q86WB0 ZC3HC1 S161 ochoa Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}.
Q86XL3 ANKLE2 S866 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8IU68 TMC8 S683 ochoa Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}.
Q8IUG5 MYO18B S2236 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IUW3 SPATA2L S252 ochoa Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) None
Q8IUW5 RELL1 S157 ochoa RELT-like protein 1 Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.
Q8IV48 ERI1 S21 ochoa 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}.
Q8IV61 RASGRP3 S563 ochoa Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) Guanine nucleotide exchange factor (GEF) for Ras and Rap1. {ECO:0000269|PubMed:10934204}.
Q8IVF2 AHNAK2 S4897 ochoa Protein AHNAK2 None
Q8IXT5 RBM12B S874 ochoa RNA-binding protein 12B (RNA-binding motif protein 12B) None
Q8IYA7 MKX S36 ochoa Homeobox protein Mohawk May act as a morphogenetic regulator of cell adhesion. {ECO:0000250}.
Q8IYB3 SRRM1 S393 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8N2Y8 RUSC2 S536 ochoa AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.
Q8NCG7 DAGLB S570 ochoa Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta) Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). {ECO:0000250|UniProtKB:Q91WC9, ECO:0000269|PubMed:14610053}.
Q8NDX1 PSD4 S448 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8NEZ4 KMT2C S2946 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NHM5 KDM2B S1018 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8TAP8 PPP1R35 S52 ochoa Protein phosphatase 1 regulatory subunit 35 During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.
Q8TB72 PUM2 S182 ochoa Pumilio homolog 2 (Pumilio-2) Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.
Q8TD16 BICD2 S606 ochoa Protein bicaudal D homolog 2 (Bic-D 2) Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}.
Q8WUA7 TBC1D22A S21 ochoa TBC1 domain family member 22A May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q8WUF5 PPP1R13L S110 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WUM0 NUP133 S50 ochoa|psp Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WWM7 ATXN2L S396 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WXD9 CASKIN1 S1257 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WYR1 PIK3R5 S468 ochoa Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
Q92835 INPP5D S1039 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.
Q96F45 ZNF503 S102 ochoa Zinc finger protein 503 May function as a transcriptional repressor. {ECO:0000250}.
Q96FS4 SIPA1 S884 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q96JY6 PDLIM2 S197 ochoa PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
Q96KS0 EGLN2 S234 psp Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}.
Q96PM9 ZNF385A S153 ochoa Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}.
Q96S66 CLCC1 S438 ochoa Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}.
Q99490 AGAP2 S818 ochoa Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
Q9BQ65 USB1 S36 ochoa U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367). {ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23022480, ECO:0000269|PubMed:23190533, ECO:0000269|PubMed:26213367, ECO:0000269|PubMed:28887445, ECO:0000269|PubMed:30215753, ECO:0000269|PubMed:31832688}.
Q9BQQ3 GORASP1 S274 psp Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.
Q9BRD0 BUD13 S126 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BRD0 BUD13 S188 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BUF5 TUBB6 S278 ochoa Tubulin beta-6 chain (Tubulin beta class V) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}.
Q9BVA1 TUBB2B S278 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9C0D5 TANC1 S1503 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H211 CDT1 S394 ochoa|psp DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H4L4 SENP3 S54 ochoa Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H5J0 ZBTB3 S549 ochoa Zinc finger and BTB domain-containing protein 3 May be involved in transcriptional regulation.
Q9H6F5 CCDC86 S160 ochoa Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}.
Q9H7S9 ZNF703 S78 ochoa Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.
Q9H8M5 CNNM2 S743 ochoa Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO:0000250|UniProtKB:Q3TWN3}.
Q9H9L7 AKIRIN1 S22 ochoa Akirin-1 Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed:34711951). {ECO:0000250|UniProtKB:Q99LF1, ECO:0000269|PubMed:34711951}.
Q9HCE9 ANO8 S641 ochoa Anoctamin-8 (Transmembrane protein 16H) Does not exhibit calcium-activated chloride channel (CaCC) activity.
Q9NSC5 HOMER3 S141 ochoa Homer protein homolog 3 (Homer-3) Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}.
Q9NYV4 CDK12 S268 ochoa Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Q9P1Y6 PHRF1 S1229 ochoa PHD and RING finger domain-containing protein 1 None
Q9P242 NYAP2 S469 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9UGJ0 PRKAG2 S71 ochoa 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}.
Q9UGP4 LIMD1 S424 ochoa|psp LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UIS9 MBD1 S399 ochoa Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}.
Q9UK80 USP21 S93 ochoa|psp Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}.
Q9ULD5 ZNF777 S623 ochoa Zinc finger protein 777 May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.
Q9ULX9 MAFF S146 ochoa Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}.
Q9UMN6 KMT2B S1890 ochoa Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q9UPP1 PHF8 S880 ochoa|psp Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}.
Q9UQ35 SRRM2 S1064 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2K7 KDM2A S731 ochoa Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.
Q9Y2X7 GIT1 S498 ochoa|psp ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y2X7 GIT1 S514 ochoa ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y3S1 WNK2 S560 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4Z2 NEUROG3 S174 psp Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}.
Q9Y6I3 EPN1 S447 ochoa Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}.
Q9Y6X9 MORC2 S696 ochoa ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}.
P05187 ALPP S438 Sugiyama Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.
P10696 ALPG S435 Sugiyama Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}.
Q9NP71 MLXIPL S556 SIGNOR Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}.
P08151 GLI1 S569 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
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reactome_id name p -log10_p
R-HSA-9619483 Activation of AMPK downstream of NMDARs 3.266796e-10 9.486
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 9.077223e-09 8.042
R-HSA-190872 Transport of connexons to the plasma membrane 1.227218e-08 7.911
R-HSA-438064 Post NMDA receptor activation events 2.113477e-07 6.675
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 4.242868e-07 6.372
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.105989e-07 6.292
R-HSA-190861 Gap junction assembly 5.907109e-07 6.229
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 1.005657e-06 5.998
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 8.322648e-07 6.080
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 9.136714e-07 6.039
R-HSA-69278 Cell Cycle, Mitotic 1.216128e-06 5.915
R-HSA-9646399 Aggrephagy 1.450862e-06 5.838
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.674414e-06 5.776
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.905468e-06 5.720
R-HSA-190828 Gap junction trafficking 2.806650e-06 5.552
R-HSA-1640170 Cell Cycle 3.597685e-06 5.444
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 4.038718e-06 5.394
R-HSA-437239 Recycling pathway of L1 4.038718e-06 5.394
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.363964e-06 5.360
R-HSA-157858 Gap junction trafficking and regulation 5.087734e-06 5.293
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 5.752037e-06 5.240
R-HSA-9833482 PKR-mediated signaling 9.473457e-06 5.023
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.191168e-05 4.924
R-HSA-983189 Kinesins 1.575156e-05 4.803
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.892847e-05 4.723
R-HSA-68886 M Phase 1.880795e-05 4.726
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.893023e-05 4.723
R-HSA-9663891 Selective autophagy 1.892847e-05 4.723
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 2.411384e-05 4.618
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 2.830647e-05 4.548
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 3.179082e-05 4.498
R-HSA-68877 Mitotic Prometaphase 3.875927e-05 4.412
R-HSA-6807878 COPI-mediated anterograde transport 3.768363e-05 4.424
R-HSA-5620920 Cargo trafficking to the periciliary membrane 4.051087e-05 4.392
R-HSA-2467813 Separation of Sister Chromatids 5.469032e-05 4.262
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 7.574179e-05 4.121
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 9.201972e-05 4.036
R-HSA-68882 Mitotic Anaphase 9.968749e-05 4.001
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.034164e-04 3.985
R-HSA-69275 G2/M Transition 1.436683e-04 3.843
R-HSA-373760 L1CAM interactions 1.433843e-04 3.843
R-HSA-453274 Mitotic G2-G2/M phases 1.552618e-04 3.809
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 2.558271e-04 3.592
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 2.594968e-04 3.586
R-HSA-5610787 Hedgehog 'off' state 3.230036e-04 3.491
R-HSA-8856688 Golgi-to-ER retrograde transport 3.403848e-04 3.468
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.806804e-04 3.419
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.422005e-04 3.354
R-HSA-5620924 Intraflagellar transport 5.053938e-04 3.296
R-HSA-1632852 Macroautophagy 5.217750e-04 3.283
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 6.383210e-04 3.195
R-HSA-199977 ER to Golgi Anterograde Transport 6.901918e-04 3.161
R-HSA-5617833 Cilium Assembly 7.478183e-04 3.126
R-HSA-9609690 HCMV Early Events 9.104973e-04 3.041
R-HSA-9612973 Autophagy 9.684438e-04 3.014
R-HSA-8986944 Transcriptional Regulation by MECP2 1.112036e-03 2.954
R-HSA-9022692 Regulation of MECP2 expression and activity 1.124490e-03 2.949
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.041959e-03 2.982
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.034123e-03 2.985
R-HSA-2132295 MHC class II antigen presentation 1.101457e-03 2.958
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 1.563293e-03 2.806
R-HSA-1234174 Cellular response to hypoxia 1.629030e-03 2.788
R-HSA-9675151 Disorders of Developmental Biology 1.899603e-03 2.721
R-HSA-5358351 Signaling by Hedgehog 2.204897e-03 2.657
R-HSA-1852241 Organelle biogenesis and maintenance 2.003996e-03 2.698
R-HSA-112315 Transmission across Chemical Synapses 2.143784e-03 2.669
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 2.234327e-03 2.651
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 3.018472e-03 2.520
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 3.913099e-03 2.407
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 3.913099e-03 2.407
R-HSA-9609646 HCMV Infection 4.166229e-03 2.380
R-HSA-948021 Transport to the Golgi and subsequent modification 4.188440e-03 2.378
R-HSA-112316 Neuronal System 4.369200e-03 2.360
R-HSA-390466 Chaperonin-mediated protein folding 5.199847e-03 2.284
R-HSA-3214842 HDMs demethylate histones 5.623168e-03 2.250
R-HSA-9022707 MECP2 regulates transcription factors 6.023506e-03 2.220
R-HSA-8849473 PTK6 Expression 6.023506e-03 2.220
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 6.023506e-03 2.220
R-HSA-8951430 RUNX3 regulates WNT signaling 6.023506e-03 2.220
R-HSA-391251 Protein folding 6.669183e-03 2.176
R-HSA-913531 Interferon Signaling 7.174576e-03 2.144
R-HSA-186712 Regulation of beta-cell development 7.660074e-03 2.116
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 8.545398e-03 2.068
R-HSA-2025928 Calcineurin activates NFAT 8.545398e-03 2.068
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 8.545398e-03 2.068
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 9.954540e-03 2.002
R-HSA-5467343 Deletions in the AMER1 gene destabilize the destruction complex 1.136176e-02 1.945
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 1.172497e-02 1.931
R-HSA-4839748 Signaling by AMER1 mutants 1.305736e-02 1.884
R-HSA-9697154 Disorders of Nervous System Development 1.474642e-02 1.831
R-HSA-9005895 Pervasive developmental disorders 1.474642e-02 1.831
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 1.474642e-02 1.831
R-HSA-209543 p75NTR recruits signalling complexes 1.474642e-02 1.831
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.278438e-02 1.893
R-HSA-4641265 Repression of WNT target genes 1.474642e-02 1.831
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.278438e-02 1.893
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.276899e-02 1.894
R-HSA-422475 Axon guidance 1.378320e-02 1.861
R-HSA-2262752 Cellular responses to stress 1.591069e-02 1.798
R-HSA-201556 Signaling by ALK 1.623247e-02 1.790
R-HSA-3214841 PKMTs methylate histone lysines 1.814256e-02 1.741
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 1.838857e-02 1.735
R-HSA-9673013 Diseases of Telomere Maintenance 2.259512e-02 1.646
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 2.259512e-02 1.646
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 2.259512e-02 1.646
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 2.259512e-02 1.646
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 2.259512e-02 1.646
R-HSA-193639 p75NTR signals via NF-kB 2.033729e-02 1.692
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.191440e-02 1.659
R-HSA-68875 Mitotic Prophase 1.957096e-02 1.708
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 2.033729e-02 1.692
R-HSA-199991 Membrane Trafficking 2.218075e-02 1.654
R-HSA-446353 Cell-extracellular matrix interactions 2.033729e-02 1.692
R-HSA-9675108 Nervous system development 2.189835e-02 1.660
R-HSA-2299718 Condensation of Prophase Chromosomes 2.459220e-02 1.609
R-HSA-8953897 Cellular responses to stimuli 2.619697e-02 1.582
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 2.698221e-02 1.569
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.766120e-02 1.558
R-HSA-3247509 Chromatin modifying enzymes 2.770679e-02 1.557
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 2.822213e-02 1.549
R-HSA-4839726 Chromatin organization 3.603311e-02 1.443
R-HSA-9671555 Signaling by PDGFR in disease 3.871550e-02 1.412
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 4.867332e-02 1.313
R-HSA-380259 Loss of Nlp from mitotic centrosomes 4.867332e-02 1.313
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 4.862951e-02 1.313
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 4.505480e-02 1.346
R-HSA-5619507 Activation of HOX genes during differentiation 4.505480e-02 1.346
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 4.071549e-02 1.390
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.702492e-02 1.328
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.702492e-02 1.328
R-HSA-200425 Carnitine shuttle 4.401258e-02 1.356
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.506899e-02 1.346
R-HSA-9700206 Signaling by ALK in cancer 4.863552e-02 1.313
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.863552e-02 1.313
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 4.401258e-02 1.356
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 5.242508e-02 1.280
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 5.242508e-02 1.280
R-HSA-8854518 AURKA Activation by TPX2 5.378612e-02 1.269
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 5.378612e-02 1.269
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 5.553919e-02 1.255
R-HSA-5579006 Defective GSS causes GSS deficiency 5.553919e-02 1.255
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 5.553919e-02 1.255
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 5.553919e-02 1.255
R-HSA-1280218 Adaptive Immune System 6.386691e-02 1.195
R-HSA-8878171 Transcriptional regulation by RUNX1 6.458281e-02 1.190
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 6.627324e-02 1.179
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 6.627324e-02 1.179
R-HSA-69560 Transcriptional activation of p53 responsive genes 6.627324e-02 1.179
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 6.666714e-02 1.176
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 7.688595e-02 1.114
R-HSA-380287 Centrosome maturation 7.058393e-02 1.151
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.792823e-02 1.108
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.792823e-02 1.108
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.792823e-02 1.108
R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 8.737868e-02 1.059
R-HSA-4791275 Signaling by WNT in cancer 7.076305e-02 1.150
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 7.076305e-02 1.150
R-HSA-74713 IRS activation 7.688595e-02 1.114
R-HSA-162582 Signal Transduction 7.733623e-02 1.112
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 7.399678e-02 1.131
R-HSA-8853659 RET signaling 8.738340e-02 1.059
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 9.083586e-02 1.042
R-HSA-1980143 Signaling by NOTCH1 7.258053e-02 1.139
R-HSA-1538133 G0 and Early G1 7.076305e-02 1.150
R-HSA-69205 G1/S-Specific Transcription 8.738340e-02 1.059
R-HSA-111465 Apoptotic cleavage of cellular proteins 7.076305e-02 1.150
R-HSA-1280215 Cytokine Signaling in Immune system 7.737977e-02 1.111
R-HSA-109582 Hemostasis 7.895042e-02 1.103
R-HSA-6794362 Protein-protein interactions at synapses 9.164935e-02 1.038
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 9.388527e-02 1.027
R-HSA-141424 Amplification of signal from the kinetochores 9.388527e-02 1.027
R-HSA-5653656 Vesicle-mediated transport 9.448001e-02 1.025
R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 9.775279e-02 1.010
R-HSA-8857538 PTK6 promotes HIF1A stabilization 9.775279e-02 1.010
R-HSA-9818749 Regulation of NFE2L2 gene expression 9.775279e-02 1.010
R-HSA-72163 mRNA Splicing - Major Pathway 9.881810e-02 1.005
R-HSA-212165 Epigenetic regulation of gene expression 1.001876e-01 0.999
R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 1.080096e-01 0.967
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 1.080096e-01 0.967
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... 1.080096e-01 0.967
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.080096e-01 0.967
R-HSA-1169092 Activation of RAS in B cells 1.181504e-01 0.928
R-HSA-9660537 Signaling by MRAS-complex mutants 1.181504e-01 0.928
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.181504e-01 0.928
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 1.281766e-01 0.892
R-HSA-9700645 ALK mutants bind TKIs 1.281766e-01 0.892
R-HSA-163765 ChREBP activates metabolic gene expression 1.478901e-01 0.830
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.478901e-01 0.830
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.478901e-01 0.830
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.478901e-01 0.830
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.575799e-01 0.802
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 1.575799e-01 0.802
R-HSA-5339716 Signaling by GSK3beta mutants 1.575799e-01 0.802
R-HSA-937039 IRAK1 recruits IKK complex 1.671602e-01 0.777
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.671602e-01 0.777
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.671602e-01 0.777
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.671602e-01 0.777
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.671602e-01 0.777
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.671602e-01 0.777
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.671602e-01 0.777
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 1.766321e-01 0.753
R-HSA-196299 Beta-catenin phosphorylation cascade 1.952556e-01 0.709
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 2.134601e-01 0.671
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 2.400018e-01 0.620
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 2.486495e-01 0.604
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.571994e-01 0.590
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 2.740099e-01 0.562
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 2.200422e-01 0.657
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.368060e-01 0.626
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.747084e-01 0.561
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 2.957544e-01 0.529
R-HSA-69618 Mitotic Spindle Checkpoint 1.350839e-01 0.869
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.766321e-01 0.753
R-HSA-9831926 Nephron development 2.312551e-01 0.636
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.296527e-01 0.887
R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1.080096e-01 0.967
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 2.134601e-01 0.671
R-HSA-3928664 Ephrin signaling 2.312551e-01 0.636
R-HSA-72172 mRNA Splicing 1.155143e-01 0.937
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.065041e-01 0.514
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 2.134601e-01 0.671
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.065041e-01 0.514
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1.671602e-01 0.777
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.656525e-01 0.576
R-HSA-9927354 Co-stimulation by ICOS 1.181504e-01 0.928
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.380894e-01 0.860
R-HSA-4839744 Signaling by APC mutants 1.478901e-01 0.830
R-HSA-209560 NF-kB is activated and signals survival 1.575799e-01 0.802
R-HSA-4839735 Signaling by AXIN mutants 1.575799e-01 0.802
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.766321e-01 0.753
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 1.859968e-01 0.730
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.312551e-01 0.636
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 2.822727e-01 0.549
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 2.740099e-01 0.562
R-HSA-5632684 Hedgehog 'on' state 2.284132e-01 0.641
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.281766e-01 0.892
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 1.380894e-01 0.860
R-HSA-426048 Arachidonate production from DAG 1.380894e-01 0.860
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells 1.478901e-01 0.830
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2.571994e-01 0.590
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.571994e-01 0.590
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.571994e-01 0.590
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 2.904420e-01 0.537
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 2.620640e-01 0.582
R-HSA-6794361 Neurexins and neuroligins 1.506071e-01 0.822
R-HSA-9932451 SWI/SNF chromatin remodelers 2.985187e-01 0.525
R-HSA-9932444 ATP-dependent chromatin remodelers 2.985187e-01 0.525
R-HSA-9839394 TGFBR3 expression 2.985187e-01 0.525
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 3.065041e-01 0.514
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 2.578496e-01 0.589
R-HSA-193704 p75 NTR receptor-mediated signalling 1.325074e-01 0.878
R-HSA-8953854 Metabolism of RNA 2.748412e-01 0.561
R-HSA-9613354 Lipophagy 1.281766e-01 0.892
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.859968e-01 0.730
R-HSA-9733458 Induction of Cell-Cell Fusion 2.044097e-01 0.689
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 2.656525e-01 0.576
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 2.822727e-01 0.549
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2.822727e-01 0.549
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2.134601e-01 0.671
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 1.438861e-01 0.842
R-HSA-74160 Gene expression (Transcription) 1.436054e-01 0.843
R-HSA-390666 Serotonin receptors 1.380894e-01 0.860
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.859968e-01 0.730
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2.044097e-01 0.689
R-HSA-912526 Interleukin receptor SHC signaling 2.822727e-01 0.549
R-HSA-195721 Signaling by WNT 1.586262e-01 0.800
R-HSA-177929 Signaling by EGFR 1.665630e-01 0.778
R-HSA-1483249 Inositol phosphate metabolism 1.700447e-01 0.769
R-HSA-73857 RNA Polymerase II Transcription 1.224294e-01 0.912
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1.766321e-01 0.753
R-HSA-5689880 Ub-specific processing proteases 1.784908e-01 0.748
R-HSA-74749 Signal attenuation 1.380894e-01 0.860
R-HSA-210990 PECAM1 interactions 1.478901e-01 0.830
R-HSA-392517 Rap1 signalling 2.400018e-01 0.620
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 2.072673e-01 0.683
R-HSA-212436 Generic Transcription Pathway 1.318341e-01 0.880
R-HSA-73887 Death Receptor Signaling 1.356894e-01 0.867
R-HSA-1169408 ISG15 antiviral mechanism 2.452153e-01 0.610
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 2.044097e-01 0.689
R-HSA-69206 G1/S Transition 2.161098e-01 0.665
R-HSA-430116 GP1b-IX-V activation signalling 1.281766e-01 0.892
R-HSA-174403 Glutathione synthesis and recycling 2.656525e-01 0.576
R-HSA-9909648 Regulation of PD-L1(CD274) expression 1.762493e-01 0.754
R-HSA-1266738 Developmental Biology 2.440076e-01 0.613
R-HSA-199418 Negative regulation of the PI3K/AKT network 2.310183e-01 0.636
R-HSA-388841 Regulation of T cell activation by CD28 family 2.098925e-01 0.678
R-HSA-201681 TCF dependent signaling in response to WNT 2.014142e-01 0.696
R-HSA-389948 Co-inhibition by PD-1 2.422000e-01 0.616
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.827950e-01 0.738
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 1.827950e-01 0.738
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.827950e-01 0.738
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 1.827950e-01 0.738
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 1.951161e-01 0.710
R-HSA-8848021 Signaling by PTK6 1.951161e-01 0.710
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 2.400018e-01 0.620
R-HSA-1483255 PI Metabolism 1.402888e-01 0.853
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 2.486495e-01 0.604
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.199012e-01 0.921
R-HSA-5687128 MAPK6/MAPK4 signaling 2.873433e-01 0.542
R-HSA-4086398 Ca2+ pathway 2.368060e-01 0.626
R-HSA-210993 Tie2 Signaling 2.312551e-01 0.636
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 3.065041e-01 0.514
R-HSA-8983711 OAS antiviral response 1.671602e-01 0.777
R-HSA-9909396 Circadian clock 2.400539e-01 0.620
R-HSA-5633007 Regulation of TP53 Activity 1.480565e-01 0.830
R-HSA-2644603 Signaling by NOTCH1 in Cancer 1.827950e-01 0.738
R-HSA-446203 Asparagine N-linked glycosylation 1.370080e-01 0.863
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1.665630e-01 0.778
R-HSA-75153 Apoptotic execution phase 1.273248e-01 0.895
R-HSA-381038 XBP1(S) activates chaperone genes 2.957544e-01 0.529
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 2.227546e-01 0.652
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 3.143990e-01 0.503
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 3.143990e-01 0.503
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 3.143990e-01 0.503
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.143990e-01 0.503
R-HSA-389357 CD28 dependent PI3K/Akt signaling 3.143990e-01 0.503
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 3.143990e-01 0.503
R-HSA-381070 IRE1alpha activates chaperones 3.208884e-01 0.494
R-HSA-167287 HIV elongation arrest and recovery 3.222046e-01 0.492
R-HSA-167290 Pausing and recovery of HIV elongation 3.222046e-01 0.492
R-HSA-113418 Formation of the Early Elongation Complex 3.222046e-01 0.492
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 3.222046e-01 0.492
R-HSA-72086 mRNA Capping 3.299217e-01 0.482
R-HSA-9006335 Signaling by Erythropoietin 3.299217e-01 0.482
R-HSA-9006936 Signaling by TGFB family members 3.325487e-01 0.478
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 3.333782e-01 0.477
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 3.375515e-01 0.472
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.375515e-01 0.472
R-HSA-68962 Activation of the pre-replicative complex 3.375515e-01 0.472
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.375515e-01 0.472
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 3.375515e-01 0.472
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.450948e-01 0.462
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.450948e-01 0.462
R-HSA-182971 EGFR downregulation 3.450948e-01 0.462
R-HSA-5607764 CLEC7A (Dectin-1) signaling 3.458023e-01 0.461
R-HSA-8878159 Transcriptional regulation by RUNX3 3.499274e-01 0.456
R-HSA-170834 Signaling by TGF-beta Receptor Complex 3.499274e-01 0.456
R-HSA-9675126 Diseases of mitotic cell cycle 3.525527e-01 0.453
R-HSA-1855170 IPs transport between nucleus and cytosol 3.599262e-01 0.444
R-HSA-159227 Transport of the SLBP independent Mature mRNA 3.599262e-01 0.444
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 3.599262e-01 0.444
R-HSA-397795 G-protein beta:gamma signalling 3.599262e-01 0.444
R-HSA-159418 Recycling of bile acids and salts 3.599262e-01 0.444
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.599262e-01 0.444
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 3.666852e-01 0.436
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 3.672161e-01 0.435
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 3.672161e-01 0.435
R-HSA-5223345 Miscellaneous transport and binding events 3.672161e-01 0.435
R-HSA-114508 Effects of PIP2 hydrolysis 3.672161e-01 0.435
R-HSA-9842860 Regulation of endogenous retroelements 3.704151e-01 0.431
R-HSA-5673000 RAF activation 3.744234e-01 0.427
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 3.744234e-01 0.427
R-HSA-180746 Nuclear import of Rev protein 3.744234e-01 0.427
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 3.744234e-01 0.427
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 3.744234e-01 0.427
R-HSA-168638 NOD1/2 Signaling Pathway 3.744234e-01 0.427
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.815491e-01 0.418
R-HSA-5688426 Deubiquitination 3.848774e-01 0.415
R-HSA-74158 RNA Polymerase III Transcription 3.885941e-01 0.411
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.885941e-01 0.411
R-HSA-9682385 FLT3 signaling in disease 3.885941e-01 0.411
R-HSA-114604 GPVI-mediated activation cascade 3.885941e-01 0.411
R-HSA-69620 Cell Cycle Checkpoints 3.925953e-01 0.406
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.955592e-01 0.403
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3.955592e-01 0.403
R-HSA-419037 NCAM1 interactions 3.955592e-01 0.403
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.955592e-01 0.403
R-HSA-2672351 Stimuli-sensing channels 3.986575e-01 0.399
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4.024454e-01 0.395
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.092536e-01 0.388
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 4.092536e-01 0.388
R-HSA-168276 NS1 Mediated Effects on Host Pathways 4.092536e-01 0.388
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 4.092536e-01 0.388
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.159847e-01 0.381
R-HSA-9670095 Inhibition of DNA recombination at telomere 4.159847e-01 0.381
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 4.159847e-01 0.381
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 4.159847e-01 0.381
R-HSA-167169 HIV Transcription Elongation 4.159847e-01 0.381
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 4.159847e-01 0.381
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 4.159847e-01 0.381
R-HSA-177243 Interactions of Rev with host cellular proteins 4.159847e-01 0.381
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.159847e-01 0.381
R-HSA-451927 Interleukin-2 family signaling 4.159847e-01 0.381
R-HSA-8868773 rRNA processing in the nucleus and cytosol 4.218122e-01 0.375
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.226394e-01 0.374
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.226394e-01 0.374
R-HSA-9607240 FLT3 Signaling 4.226394e-01 0.374
R-HSA-9656223 Signaling by RAF1 mutants 4.292188e-01 0.367
R-HSA-5674135 MAP2K and MAPK activation 4.292188e-01 0.367
R-HSA-5610780 Degradation of GLI1 by the proteasome 4.292188e-01 0.367
R-HSA-5675221 Negative regulation of MAPK pathway 4.292188e-01 0.367
R-HSA-6811438 Intra-Golgi traffic 4.292188e-01 0.367
R-HSA-2871809 FCERI mediated Ca+2 mobilization 4.340821e-01 0.362
R-HSA-165159 MTOR signalling 4.357235e-01 0.361
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 4.357235e-01 0.361
R-HSA-1592230 Mitochondrial biogenesis 4.418041e-01 0.355
R-HSA-1433557 Signaling by SCF-KIT 4.421545e-01 0.354
R-HSA-2219528 PI3K/AKT Signaling in Cancer 4.456435e-01 0.351
R-HSA-3214858 RMTs methylate histone arginines 4.485127e-01 0.348
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 4.485127e-01 0.348
R-HSA-373752 Netrin-1 signaling 4.485127e-01 0.348
R-HSA-375280 Amine ligand-binding receptors 4.485127e-01 0.348
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 4.547987e-01 0.342
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 4.547987e-01 0.342
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 4.610135e-01 0.336
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 4.610135e-01 0.336
R-HSA-9649948 Signaling downstream of RAS mutants 4.610135e-01 0.336
R-HSA-6802949 Signaling by RAS mutants 4.610135e-01 0.336
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 4.610135e-01 0.336
R-HSA-9839373 Signaling by TGFBR3 4.610135e-01 0.336
R-HSA-5357905 Regulation of TNFR1 signaling 4.610135e-01 0.336
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 4.671578e-01 0.331
R-HSA-389356 Co-stimulation by CD28 4.732325e-01 0.325
R-HSA-69563 p53-Dependent G1 DNA Damage Response 4.792383e-01 0.319
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 4.792383e-01 0.319
R-HSA-3700989 Transcriptional Regulation by TP53 4.816296e-01 0.317
R-HSA-1257604 PIP3 activates AKT signaling 4.858989e-01 0.313
R-HSA-1169091 Activation of NF-kappaB in B cells 4.910463e-01 0.309
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 4.968500e-01 0.304
R-HSA-72187 mRNA 3'-end processing 4.968500e-01 0.304
R-HSA-112382 Formation of RNA Pol II elongation complex 4.968500e-01 0.304
R-HSA-68949 Orc1 removal from chromatin 4.968500e-01 0.304
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 4.968500e-01 0.304
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 5.025879e-01 0.299
R-HSA-75955 RNA Polymerase II Transcription Elongation 5.025879e-01 0.299
R-HSA-445355 Smooth Muscle Contraction 5.025879e-01 0.299
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 5.138693e-01 0.289
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 5.194141e-01 0.284
R-HSA-193648 NRAGE signals death through JNK 5.194141e-01 0.284
R-HSA-75893 TNF signaling 5.194141e-01 0.284
R-HSA-8951664 Neddylation 5.208274e-01 0.283
R-HSA-163685 Integration of energy metabolism 5.226750e-01 0.282
R-HSA-9018519 Estrogen-dependent gene expression 5.226750e-01 0.282
R-HSA-3858494 Beta-catenin independent WNT signaling 5.226750e-01 0.282
R-HSA-2980766 Nuclear Envelope Breakdown 5.248961e-01 0.280
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.248961e-01 0.280
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 5.303159e-01 0.275
R-HSA-381119 Unfolded Protein Response (UPR) 5.330856e-01 0.273
R-HSA-194441 Metabolism of non-coding RNA 5.356742e-01 0.271
R-HSA-191859 snRNP Assembly 5.356742e-01 0.271
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 5.409716e-01 0.267
R-HSA-5362517 Signaling by Retinoic Acid 5.409716e-01 0.267
R-HSA-8943724 Regulation of PTEN gene transcription 5.409716e-01 0.267
R-HSA-156590 Glutathione conjugation 5.409716e-01 0.267
R-HSA-168325 Viral Messenger RNA Synthesis 5.462090e-01 0.263
R-HSA-73856 RNA Polymerase II Transcription Termination 5.462090e-01 0.263
R-HSA-211976 Endogenous sterols 5.462090e-01 0.263
R-HSA-450294 MAP kinase activation 5.462090e-01 0.263
R-HSA-162599 Late Phase of HIV Life Cycle 5.467250e-01 0.262
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 5.467250e-01 0.262
R-HSA-8856828 Clathrin-mediated endocytosis 5.500914e-01 0.260
R-HSA-72312 rRNA processing 5.508857e-01 0.259
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 5.513869e-01 0.259
R-HSA-6784531 tRNA processing in the nucleus 5.513869e-01 0.259
R-HSA-375165 NCAM signaling for neurite out-growth 5.513869e-01 0.259
R-HSA-9707616 Heme signaling 5.513869e-01 0.259
R-HSA-9824446 Viral Infection Pathways 5.542877e-01 0.256
R-HSA-597592 Post-translational protein modification 5.543201e-01 0.256
R-HSA-69615 G1/S DNA Damage Checkpoints 5.565061e-01 0.255
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 5.565061e-01 0.255
R-HSA-74751 Insulin receptor signalling cascade 5.615671e-01 0.251
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 5.615671e-01 0.251
R-HSA-8939211 ESR-mediated signaling 5.641797e-01 0.249
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.665708e-01 0.247
R-HSA-69242 S Phase 5.666604e-01 0.247
R-HSA-157118 Signaling by NOTCH 5.720414e-01 0.243
R-HSA-9755511 KEAP1-NFE2L2 pathway 5.763904e-01 0.239
R-HSA-9830369 Kidney development 5.764082e-01 0.239
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 5.764082e-01 0.239
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 5.795983e-01 0.237
R-HSA-167172 Transcription of the HIV genome 5.812434e-01 0.236
R-HSA-204005 COPII-mediated vesicle transport 5.907496e-01 0.229
R-HSA-69202 Cyclin E associated events during G1/S transition 5.907496e-01 0.229
R-HSA-448424 Interleukin-17 signaling 5.907496e-01 0.229
R-HSA-75105 Fatty acyl-CoA biosynthesis 5.907496e-01 0.229
R-HSA-9006925 Intracellular signaling by second messengers 5.951461e-01 0.225
R-HSA-9610379 HCMV Late Events 5.953718e-01 0.225
R-HSA-162587 HIV Life Cycle 5.953718e-01 0.225
R-HSA-453276 Regulation of mitotic cell cycle 5.954219e-01 0.225
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 5.954219e-01 0.225
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 6.000411e-01 0.222
R-HSA-5578749 Transcriptional regulation by small RNAs 6.000411e-01 0.222
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.000411e-01 0.222
R-HSA-69052 Switching of origins to a post-replicative state 6.046079e-01 0.219
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 6.046079e-01 0.219
R-HSA-5683057 MAPK family signaling cascades 6.059474e-01 0.218
R-HSA-674695 RNA Polymerase II Pre-transcription Events 6.091229e-01 0.215
R-HSA-109581 Apoptosis 6.107013e-01 0.214
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 6.223623e-01 0.206
R-HSA-383280 Nuclear Receptor transcription pathway 6.266756e-01 0.203
R-HSA-416482 G alpha (12/13) signalling events 6.266756e-01 0.203
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 6.309398e-01 0.200
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes 6.309398e-01 0.200
R-HSA-9006931 Signaling by Nuclear Receptors 6.393219e-01 0.194
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 6.393236e-01 0.194
R-HSA-5621481 C-type lectin receptors (CLRs) 6.400311e-01 0.194
R-HSA-9711123 Cellular response to chemical stress 6.410738e-01 0.193
R-HSA-9707564 Cytoprotection by HMOX1 6.475179e-01 0.189
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.515453e-01 0.186
R-HSA-76002 Platelet activation, signaling and aggregation 6.548144e-01 0.184
R-HSA-6802957 Oncogenic MAPK signaling 6.555270e-01 0.183
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.594634e-01 0.181
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 6.633551e-01 0.178
R-HSA-446728 Cell junction organization 6.637651e-01 0.178
R-HSA-112310 Neurotransmitter release cycle 6.784845e-01 0.168
R-HSA-202424 Downstream TCR signaling 6.784845e-01 0.168
R-HSA-983712 Ion channel transport 6.884252e-01 0.162
R-HSA-2682334 EPH-Ephrin signaling 6.893859e-01 0.162
R-HSA-74752 Signaling by Insulin receptor 6.893859e-01 0.162
R-HSA-9772573 Late SARS-CoV-2 Infection Events 6.893859e-01 0.162
R-HSA-68867 Assembly of the pre-replicative complex 6.929374e-01 0.159
R-HSA-1483257 Phospholipid metabolism 6.999311e-01 0.155
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 7.067440e-01 0.151
R-HSA-157579 Telomere Maintenance 7.100981e-01 0.149
R-HSA-8957275 Post-translational protein phosphorylation 7.134140e-01 0.147
R-HSA-975871 MyD88 cascade initiated on plasma membrane 7.134140e-01 0.147
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 7.134140e-01 0.147
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 7.134140e-01 0.147
R-HSA-192105 Synthesis of bile acids and bile salts 7.166922e-01 0.145
R-HSA-70171 Glycolysis 7.199331e-01 0.143
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.222839e-01 0.141
R-HSA-9020702 Interleukin-1 signaling 7.231371e-01 0.141
R-HSA-9009391 Extra-nuclear estrogen signaling 7.231371e-01 0.141
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.263046e-01 0.139
R-HSA-5357801 Programmed Cell Death 7.291250e-01 0.137
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 7.325320e-01 0.135
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 7.347592e-01 0.134
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 7.355927e-01 0.133
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 7.386185e-01 0.132
R-HSA-1500931 Cell-Cell communication 7.404599e-01 0.130
R-HSA-69239 Synthesis of DNA 7.445672e-01 0.128
R-HSA-211000 Gene Silencing by RNA 7.445672e-01 0.128
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 7.474908e-01 0.126
R-HSA-69002 DNA Replication Pre-Initiation 7.503812e-01 0.125
R-HSA-975155 MyD88 dependent cascade initiated on endosome 7.503812e-01 0.125
R-HSA-449147 Signaling by Interleukins 7.508837e-01 0.124
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 7.532386e-01 0.123
R-HSA-166166 MyD88-independent TLR4 cascade 7.532386e-01 0.123
R-HSA-194068 Bile acid and bile salt metabolism 7.532386e-01 0.123
R-HSA-202403 TCR signaling 7.532386e-01 0.123
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 7.616173e-01 0.118
R-HSA-9855142 Cellular responses to mechanical stimuli 7.643468e-01 0.117
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 7.670452e-01 0.115
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 7.697129e-01 0.114
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.697129e-01 0.114
R-HSA-162906 HIV Infection 7.750560e-01 0.111
R-HSA-9705683 SARS-CoV-2-host interactions 7.769735e-01 0.110
R-HSA-70326 Glucose metabolism 7.775351e-01 0.109
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 7.826024e-01 0.106
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 7.826024e-01 0.106
R-HSA-73886 Chromosome Maintenance 7.875550e-01 0.104
R-HSA-3371556 Cellular response to heat stress 7.875550e-01 0.104
R-HSA-9759194 Nuclear events mediated by NFE2L2 7.875550e-01 0.104
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 7.899890e-01 0.102
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 7.899890e-01 0.102
R-HSA-9816359 Maternal to zygotic transition (MZT) 7.923953e-01 0.101
R-HSA-202733 Cell surface interactions at the vascular wall 7.936000e-01 0.100
R-HSA-162909 Host Interactions of HIV factors 7.947742e-01 0.100
R-HSA-9694516 SARS-CoV-2 Infection 7.952753e-01 0.099
R-HSA-168256 Immune System 8.034589e-01 0.095
R-HSA-114608 Platelet degranulation 8.040217e-01 0.095
R-HSA-9843745 Adipogenesis 8.150002e-01 0.089
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 8.192184e-01 0.087
R-HSA-6807070 PTEN Regulation 8.332426e-01 0.079
R-HSA-9734767 Developmental Cell Lineages 8.356558e-01 0.078
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 8.514203e-01 0.070
R-HSA-9856651 MITF-M-dependent gene expression 8.548120e-01 0.068
R-HSA-9679191 Potential therapeutics for SARS 8.548120e-01 0.068
R-HSA-446652 Interleukin-1 family signaling 8.581268e-01 0.066
R-HSA-69306 DNA Replication 8.597558e-01 0.066
R-HSA-1989781 PPARA activates gene expression 8.629583e-01 0.064
R-HSA-168273 Influenza Viral RNA Transcription and Replication 8.629583e-01 0.064
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 8.660880e-01 0.062
R-HSA-8978868 Fatty acid metabolism 8.692952e-01 0.061
R-HSA-5673001 RAF/MAP kinase cascade 8.698494e-01 0.061
R-HSA-5684996 MAPK1/MAPK3 signaling 8.778748e-01 0.057
R-HSA-211897 Cytochrome P450 - arranged by substrate type 8.807017e-01 0.055
R-HSA-5619102 SLC transporter disorders 8.807017e-01 0.055
R-HSA-1643685 Disease 8.828722e-01 0.054
R-HSA-72306 tRNA processing 8.860928e-01 0.053
R-HSA-418555 G alpha (s) signalling events 8.874023e-01 0.052
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.899765e-01 0.051
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.899765e-01 0.051
R-HSA-168255 Influenza Infection 8.973531e-01 0.047
R-HSA-9679506 SARS-CoV Infections 8.978926e-01 0.047
R-HSA-168898 Toll-like Receptor Cascades 9.106627e-01 0.041
R-HSA-6798695 Neutrophil degranulation 9.125023e-01 0.040
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 9.156881e-01 0.038
R-HSA-397014 Muscle contraction 9.307628e-01 0.031
R-HSA-9730414 MITF-M-regulated melanocyte development 9.315608e-01 0.031
R-HSA-418990 Adherens junctions interactions 9.354161e-01 0.029
R-HSA-156580 Phase II - Conjugation of compounds 9.493850e-01 0.023
R-HSA-5619115 Disorders of transmembrane transporters 9.538767e-01 0.021
R-HSA-421270 Cell-cell junction organization 9.559715e-01 0.020
R-HSA-5663205 Infectious disease 9.609337e-01 0.017
R-HSA-416476 G alpha (q) signalling events 9.621478e-01 0.017
R-HSA-211945 Phase I - Functionalization of compounds 9.678384e-01 0.014
R-HSA-392499 Metabolism of proteins 9.764517e-01 0.010
R-HSA-8957322 Metabolism of steroids 9.811885e-01 0.008
R-HSA-388396 GPCR downstream signalling 9.820913e-01 0.008
R-HSA-211859 Biological oxidations 9.866659e-01 0.006
R-HSA-372790 Signaling by GPCR 9.912813e-01 0.004
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.918043e-01 0.004
R-HSA-5668914 Diseases of metabolism 9.944369e-01 0.002
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.959981e-01 0.002
R-HSA-168249 Innate Immune System 9.985035e-01 0.001
R-HSA-500792 GPCR ligand binding 9.991795e-01 0.000
R-HSA-382551 Transport of small molecules 9.993582e-01 0.000
R-HSA-556833 Metabolism of lipids 9.996396e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDK18CDK18 0.816 0.750 1 0.906
HIPK2HIPK2 0.811 0.672 1 0.896
CDK19CDK19 0.810 0.747 1 0.894
CDK16CDK16 0.805 0.724 1 0.911
KISKIS 0.805 0.593 1 0.866
CDK8CDK8 0.804 0.738 1 0.873
P38BP38B 0.804 0.773 1 0.882
CDK17CDK17 0.804 0.720 1 0.915
P38GP38G 0.801 0.715 1 0.917
P38DP38D 0.801 0.709 1 0.946
CDK1CDK1 0.801 0.686 1 0.890
ERK1ERK1 0.800 0.738 1 0.891
CDK3CDK3 0.797 0.611 1 0.917
MAKMAK 0.797 0.662 -2 0.916
CDK7CDK7 0.796 0.688 1 0.885
DYRK2DYRK2 0.795 0.644 1 0.844
CDK5CDK5 0.795 0.690 1 0.868
JNK2JNK2 0.794 0.705 1 0.900
P38AP38A 0.794 0.769 1 0.839
CDK13CDK13 0.794 0.664 1 0.893
CDK12CDK12 0.794 0.670 1 0.902
CDK14CDK14 0.792 0.708 1 0.876
DYRK4DYRK4 0.792 0.630 1 0.907
CDK10CDK10 0.790 0.647 1 0.889
CLK3CLK3 0.786 0.438 1 0.648
HIPK4HIPK4 0.786 0.513 1 0.680
JNK3JNK3 0.785 0.679 1 0.887
HIPK1HIPK1 0.784 0.587 1 0.827
DYRK1BDYRK1B 0.779 0.591 1 0.867
DYRK1ADYRK1A 0.778 0.574 1 0.811
CDK9CDK9 0.778 0.625 1 0.885
JNK1JNK1 0.775 0.625 1 0.896
CDK6CDK6 0.774 0.654 1 0.889
SRPK1SRPK1 0.773 0.305 -3 0.677
CDK4CDK4 0.772 0.667 1 0.909
ERK2ERK2 0.772 0.664 1 0.855
HIPK3HIPK3 0.771 0.574 1 0.795
CLK2CLK2 0.770 0.351 -3 0.666
ICKICK 0.770 0.522 -3 0.737
NLKNLK 0.770 0.593 1 0.676
CDKL5CDKL5 0.769 0.351 -3 0.701
DYRK3DYRK3 0.768 0.474 1 0.797
MOKMOK 0.765 0.548 1 0.743
ERK5ERK5 0.763 0.373 1 0.605
MTORMTOR 0.762 0.366 1 0.474
SRPK2SRPK2 0.762 0.249 -3 0.606
CDKL1CDKL1 0.759 0.306 -3 0.709
CDK2CDK2 0.757 0.473 1 0.799
CLK4CLK4 0.755 0.299 -3 0.672
CLK1CLK1 0.754 0.323 -3 0.636
SRPK3SRPK3 0.753 0.237 -3 0.651
COTCOT 0.750 -0.011 2 0.808
PRP4PRP4 0.747 0.392 -3 0.716
ATRATR 0.742 0.074 1 0.429
CDC7CDC7 0.739 -0.012 1 0.347
MOSMOS 0.739 0.030 1 0.393
NDR2NDR2 0.739 0.040 -3 0.726
PIM3PIM3 0.738 -0.003 -3 0.742
PRPKPRPK 0.735 -0.010 -1 0.751
MPSK1MPSK1 0.733 0.297 1 0.395
ERK7ERK7 0.732 0.233 2 0.499
GRK7GRK7 0.731 0.073 1 0.333
TBK1TBK1 0.731 -0.070 1 0.272
PRKD1PRKD1 0.731 0.007 -3 0.708
MST4MST4 0.731 0.031 2 0.764
AURCAURC 0.730 0.022 -2 0.535
RSK2RSK2 0.730 0.005 -3 0.677
CAMK1BCAMK1B 0.729 -0.022 -3 0.736
CHAK2CHAK2 0.728 0.001 -1 0.678
GRK1GRK1 0.728 -0.015 -2 0.540
PIM1PIM1 0.728 0.023 -3 0.689
SKMLCKSKMLCK 0.728 -0.016 -2 0.652
RAF1RAF1 0.728 -0.118 1 0.324
WNK1WNK1 0.728 -0.017 -2 0.649
IKKBIKKB 0.727 -0.176 -2 0.478
IKKEIKKE 0.726 -0.128 1 0.268
NDR1NDR1 0.726 -0.023 -3 0.712
BMPR2BMPR2 0.726 -0.130 -2 0.597
P90RSKP90RSK 0.726 0.005 -3 0.685
PRKD2PRKD2 0.726 -0.005 -3 0.650
PDHK4PDHK4 0.726 -0.088 1 0.387
GCN2GCN2 0.725 -0.175 2 0.702
PKCDPKCD 0.725 0.026 2 0.707
PKACBPKACB 0.725 0.030 -2 0.526
NUAK2NUAK2 0.725 0.013 -3 0.724
PKCAPKCA 0.724 0.079 2 0.643
PKN2PKN2 0.724 -0.022 -3 0.709
IRE1IRE1 0.724 0.009 1 0.334
GSK3AGSK3A 0.723 0.179 4 0.375
MLK3MLK3 0.723 0.039 2 0.661
CAMLCKCAMLCK 0.723 -0.002 -2 0.629
MLK1MLK1 0.723 -0.055 2 0.728
DAPK2DAPK2 0.722 -0.009 -3 0.744
NIKNIK 0.722 -0.032 -3 0.744
NEK6NEK6 0.722 -0.092 -2 0.562
PKACGPKACG 0.722 -0.022 -2 0.549
DNAPKDNAPK 0.722 0.043 1 0.399
PKN3PKN3 0.722 -0.037 -3 0.704
CK1ECK1E 0.722 0.081 -3 0.636
PKCGPKCG 0.722 0.042 2 0.656
MAPKAPK2MAPKAPK2 0.721 -0.021 -3 0.629
GRK5GRK5 0.721 -0.110 -3 0.768
RSK3RSK3 0.720 -0.019 -3 0.664
FAM20CFAM20C 0.720 0.012 2 0.592
ULK2ULK2 0.720 -0.172 2 0.696
MARK4MARK4 0.720 -0.005 4 0.707
PRKXPRKX 0.720 0.033 -3 0.597
DSTYKDSTYK 0.720 -0.178 2 0.804
RIPK3RIPK3 0.720 -0.083 3 0.653
TGFBR2TGFBR2 0.720 -0.116 -2 0.519
CAMK2GCAMK2G 0.719 -0.110 2 0.733
PDHK1PDHK1 0.718 -0.149 1 0.365
ATMATM 0.718 -0.033 1 0.397
PKCBPKCB 0.718 0.011 2 0.652
PAK1PAK1 0.718 -0.016 -2 0.639
MNK2MNK2 0.718 -0.010 -2 0.595
AKT2AKT2 0.717 0.038 -3 0.603
MAPKAPK3MAPKAPK3 0.717 -0.054 -3 0.651
NIM1NIM1 0.717 0.035 3 0.689
MLK2MLK2 0.716 -0.028 2 0.736
LATS2LATS2 0.716 -0.050 -5 0.703
CK1DCK1D 0.716 0.081 -3 0.594
RSK4RSK4 0.715 0.011 -3 0.660
IKKAIKKA 0.715 -0.118 -2 0.482
AMPKA1AMPKA1 0.715 -0.044 -3 0.721
BMPR1BBMPR1B 0.715 -0.063 1 0.292
NEK7NEK7 0.714 -0.203 -3 0.731
LATS1LATS1 0.713 0.017 -3 0.741
CAMK2DCAMK2D 0.713 -0.088 -3 0.705
BCKDKBCKDK 0.713 -0.117 -1 0.702
P70S6KBP70S6KB 0.713 -0.042 -3 0.677
SMG1SMG1 0.713 -0.036 1 0.418
PKCZPKCZ 0.713 0.002 2 0.692
MNK1MNK1 0.713 -0.008 -2 0.590
PAK3PAK3 0.713 -0.053 -2 0.612
AMPKA2AMPKA2 0.712 -0.026 -3 0.692
PAK6PAK6 0.712 -0.008 -2 0.559
MSK2MSK2 0.712 -0.029 -3 0.657
PKG2PKG2 0.712 -0.020 -2 0.523
AURBAURB 0.712 -0.015 -2 0.527
DLKDLK 0.711 -0.134 1 0.329
CK1G1CK1G1 0.711 0.037 -3 0.622
SGK3SGK3 0.711 0.011 -3 0.651
MLK4MLK4 0.711 -0.018 2 0.646
PRKD3PRKD3 0.711 -0.015 -3 0.630
CAMK2ACAMK2A 0.711 -0.031 2 0.722
IRE2IRE2 0.711 -0.019 2 0.672
GRK6GRK6 0.710 -0.129 1 0.317
PINK1PINK1 0.710 0.107 1 0.533
AURAAURA 0.710 -0.013 -2 0.520
MASTLMASTL 0.710 -0.140 -2 0.557
CK1A2CK1A2 0.710 0.065 -3 0.595
VRK2VRK2 0.710 0.058 1 0.434
WNK3WNK3 0.709 -0.176 1 0.331
RIPK1RIPK1 0.709 -0.144 1 0.319
NEK9NEK9 0.709 -0.160 2 0.738
PIM2PIM2 0.708 0.014 -3 0.641
TSSK1TSSK1 0.708 -0.045 -3 0.740
QSKQSK 0.708 0.005 4 0.691
PHKG1PHKG1 0.708 -0.054 -3 0.704
PKRPKR 0.708 -0.055 1 0.359
CAMK2BCAMK2B 0.707 -0.063 2 0.711
MSK1MSK1 0.707 -0.022 -3 0.649
PKCHPKCH 0.707 -0.017 2 0.630
AKT1AKT1 0.707 0.026 -3 0.613
TSSK2TSSK2 0.707 -0.089 -5 0.814
TTBK2TTBK2 0.706 -0.149 2 0.617
GRK4GRK4 0.706 -0.159 -2 0.545
TGFBR1TGFBR1 0.706 -0.096 -2 0.509
ALK4ALK4 0.706 -0.107 -2 0.533
PAK2PAK2 0.705 -0.051 -2 0.617
TLK2TLK2 0.705 -0.115 1 0.342
HUNKHUNK 0.705 -0.199 2 0.719
TAO3TAO3 0.705 0.061 1 0.340
PKACAPKACA 0.705 0.006 -2 0.496
MST3MST3 0.705 0.035 2 0.751
ULK1ULK1 0.704 -0.205 -3 0.675
QIKQIK 0.704 -0.047 -3 0.703
CAMK4CAMK4 0.703 -0.119 -3 0.684
MYLK4MYLK4 0.703 -0.046 -2 0.579
BUB1BUB1 0.703 0.088 -5 0.821
CHAK1CHAK1 0.702 -0.097 2 0.702
SIKSIK 0.702 -0.013 -3 0.640
ACVR2AACVR2A 0.702 -0.118 -2 0.506
NUAK1NUAK1 0.702 -0.050 -3 0.653
MEK1MEK1 0.702 -0.114 2 0.756
ANKRD3ANKRD3 0.701 -0.219 1 0.352
GSK3BGSK3B 0.701 0.035 4 0.369
YSK4YSK4 0.700 -0.151 1 0.290
PKCEPKCE 0.700 0.040 2 0.641
GRK2GRK2 0.700 -0.080 -2 0.478
MARK3MARK3 0.700 -0.022 4 0.642
ACVR2BACVR2B 0.700 -0.129 -2 0.509
PKCTPKCT 0.699 -0.014 2 0.638
NEK2NEK2 0.699 -0.130 2 0.717
DRAK1DRAK1 0.699 -0.106 1 0.281
MELKMELK 0.699 -0.095 -3 0.671
PASKPASK 0.698 -0.009 -3 0.763
DCAMKL1DCAMKL1 0.697 -0.040 -3 0.669
PKCIPKCI 0.697 0.001 2 0.660
AKT3AKT3 0.697 0.026 -3 0.561
MEKK2MEKK2 0.697 -0.042 2 0.712
PLK1PLK1 0.697 -0.185 -2 0.522
PLK4PLK4 0.697 -0.091 2 0.537
PAK5PAK5 0.696 -0.026 -2 0.535
WNK4WNK4 0.696 -0.057 -2 0.637
MEK5MEK5 0.696 -0.085 2 0.733
CAMK1GCAMK1G 0.696 -0.053 -3 0.645
MAPKAPK5MAPKAPK5 0.695 -0.102 -3 0.618
SGK1SGK1 0.695 0.039 -3 0.542
ALK2ALK2 0.694 -0.132 -2 0.508
ZAKZAK 0.694 -0.101 1 0.299
MEKK3MEKK3 0.694 -0.115 1 0.318
IRAK4IRAK4 0.694 -0.080 1 0.315
MARK2MARK2 0.693 -0.046 4 0.605
PAK4PAK4 0.693 -0.026 -2 0.552
MEKK1MEKK1 0.692 -0.104 1 0.336
PHKG2PHKG2 0.692 -0.051 -3 0.657
TAO2TAO2 0.692 0.018 2 0.756
GRK3GRK3 0.692 -0.073 -2 0.441
BRSK1BRSK1 0.692 -0.083 -3 0.665
BMPR1ABMPR1A 0.692 -0.097 1 0.276
TNIKTNIK 0.692 0.047 3 0.842
GCKGCK 0.692 0.017 1 0.319
PLK3PLK3 0.691 -0.149 2 0.688
DAPK3DAPK3 0.691 -0.024 -3 0.691
SMMLCKSMMLCK 0.691 -0.039 -3 0.694
NEK5NEK5 0.690 -0.135 1 0.341
CHK1CHK1 0.690 -0.085 -3 0.673
HRIHRI 0.690 -0.159 -2 0.563
CK2A2CK2A2 0.690 -0.038 1 0.268
PERKPERK 0.690 -0.175 -2 0.535
BRSK2BRSK2 0.690 -0.099 -3 0.671
MAP3K15MAP3K15 0.690 0.047 1 0.309
HGKHGK 0.690 0.022 3 0.836
PDK1PDK1 0.689 -0.026 1 0.344
MEKK6MEKK6 0.688 0.013 1 0.331
KHS1KHS1 0.688 0.045 1 0.311
GAKGAK 0.688 -0.036 1 0.388
KHS2KHS2 0.688 0.059 1 0.325
SBKSBK 0.687 0.078 -3 0.498
HPK1HPK1 0.687 0.000 1 0.312
DCAMKL2DCAMKL2 0.687 -0.064 -3 0.677
TLK1TLK1 0.687 -0.176 -2 0.538
MARK1MARK1 0.687 -0.069 4 0.661
EEF2KEEF2K 0.687 0.026 3 0.821
LKB1LKB1 0.687 -0.060 -3 0.704
NEK11NEK11 0.686 -0.073 1 0.329
BRAFBRAF 0.686 -0.154 -4 0.793
HASPINHASPIN 0.686 0.043 -1 0.605
PKN1PKN1 0.685 -0.023 -3 0.613
MINKMINK 0.685 -0.024 1 0.298
DAPK1DAPK1 0.684 -0.032 -3 0.682
MRCKBMRCKB 0.684 -0.005 -3 0.616
ROCK2ROCK2 0.683 -0.006 -3 0.672
SNRKSNRK 0.683 -0.184 2 0.590
LRRK2LRRK2 0.682 0.006 2 0.749
CK2A1CK2A1 0.682 -0.044 1 0.253
CK1ACK1A 0.681 0.036 -3 0.530
P70S6KP70S6K 0.681 -0.074 -3 0.597
CAMK1DCAMK1D 0.681 -0.051 -3 0.571
SSTKSSTK 0.681 -0.110 4 0.688
PBKPBK 0.681 -0.012 1 0.364
NEK8NEK8 0.680 -0.167 2 0.726
TTBK1TTBK1 0.680 -0.147 2 0.550
DMPK1DMPK1 0.680 0.026 -3 0.647
NEK4NEK4 0.679 -0.121 1 0.310
CHK2CHK2 0.678 -0.019 -3 0.549
LOKLOK 0.678 -0.079 -2 0.527
MRCKAMRCKA 0.678 -0.026 -3 0.631
CAMKK1CAMKK1 0.678 -0.215 -2 0.485
MST2MST2 0.677 -0.124 1 0.313
VRK1VRK1 0.677 -0.095 2 0.762
NEK1NEK1 0.677 -0.082 1 0.309
SLKSLK 0.676 -0.078 -2 0.497
CAMKK2CAMKK2 0.676 -0.185 -2 0.502
YANK3YANK3 0.676 -0.008 2 0.366
YSK1YSK1 0.676 -0.014 2 0.710
CAMK1ACAMK1A 0.673 -0.031 -3 0.552
TAK1TAK1 0.673 -0.179 1 0.322
PDHK3_TYRPDHK3_TYR 0.672 0.176 4 0.781
STK33STK33 0.671 -0.119 2 0.540
PLK2PLK2 0.671 -0.089 -3 0.678
IRAK1IRAK1 0.671 -0.221 -1 0.639
MYO3BMYO3B 0.671 0.017 2 0.736
ROCK1ROCK1 0.670 -0.017 -3 0.633
OSR1OSR1 0.668 -0.061 2 0.710
PKG1PKG1 0.668 -0.056 -2 0.455
MST1MST1 0.668 -0.131 1 0.299
BIKEBIKE 0.668 -0.019 1 0.359
AAK1AAK1 0.666 0.022 1 0.346
CRIKCRIK 0.665 -0.012 -3 0.613
TAO1TAO1 0.665 -0.012 1 0.292
PDHK4_TYRPDHK4_TYR 0.665 0.101 2 0.803
MYO3AMYO3A 0.665 -0.006 1 0.318
LIMK2_TYRLIMK2_TYR 0.665 0.142 -3 0.746
MAP2K4_TYRMAP2K4_TYR 0.664 0.112 -1 0.775
ASK1ASK1 0.664 -0.037 1 0.303
TTKTTK 0.663 -0.086 -2 0.552
PKMYT1_TYRPKMYT1_TYR 0.663 0.181 3 0.786
NEK3NEK3 0.663 -0.107 1 0.317
TESK1_TYRTESK1_TYR 0.663 0.065 3 0.822
MEK2MEK2 0.662 -0.180 2 0.716
ALPHAK3ALPHAK3 0.661 -0.053 -1 0.661
RIPK2RIPK2 0.661 -0.209 1 0.276
MAP2K6_TYRMAP2K6_TYR 0.661 0.056 -1 0.759
PDHK1_TYRPDHK1_TYR 0.660 0.047 -1 0.749
MAP2K7_TYRMAP2K7_TYR 0.657 0.005 2 0.769
BMPR2_TYRBMPR2_TYR 0.657 0.008 -1 0.754
CK1G3CK1G3 0.656 0.024 -3 0.493
PINK1_TYRPINK1_TYR 0.653 -0.068 1 0.380
LIMK1_TYRLIMK1_TYR 0.652 0.037 2 0.763
RETRET 0.651 -0.081 1 0.345
MST1RMST1R 0.651 -0.039 3 0.758
CSF1RCSF1R 0.650 -0.012 3 0.727
ABL2ABL2 0.649 -0.042 -1 0.681
JAK2JAK2 0.648 -0.057 1 0.349
EPHB4EPHB4 0.646 -0.067 -1 0.673
TYK2TYK2 0.646 -0.118 1 0.334
TXKTXK 0.646 -0.037 1 0.310
JAK1JAK1 0.646 -0.002 1 0.304
ABL1ABL1 0.645 -0.053 -1 0.682
ROS1ROS1 0.645 -0.060 3 0.713
YANK2YANK2 0.645 -0.020 2 0.383
YES1YES1 0.644 -0.064 -1 0.716
EPHA6EPHA6 0.644 -0.093 -1 0.691
LCKLCK 0.644 -0.042 -1 0.691
NEK10_TYRNEK10_TYR 0.643 -0.050 1 0.288
TYRO3TYRO3 0.643 -0.115 3 0.740
TNNI3K_TYRTNNI3K_TYR 0.642 0.008 1 0.365
TNK2TNK2 0.642 -0.044 3 0.698
BLKBLK 0.642 -0.040 -1 0.692
TNK1TNK1 0.640 -0.013 3 0.719
JAK3JAK3 0.640 -0.103 1 0.331
FGRFGR 0.639 -0.134 1 0.330
KITKIT 0.639 -0.080 3 0.727
HCKHCK 0.639 -0.102 -1 0.692
STLK3STLK3 0.638 -0.184 1 0.281
ITKITK 0.638 -0.092 -1 0.671
KDRKDR 0.638 -0.063 3 0.677
FERFER 0.637 -0.154 1 0.346
WEE1_TYRWEE1_TYR 0.637 -0.027 -1 0.647
FGFR2FGFR2 0.637 -0.060 3 0.713
CK1G2CK1G2 0.637 0.002 -3 0.558
BMXBMX 0.636 -0.066 -1 0.611
METMET 0.636 -0.069 3 0.726
FLT3FLT3 0.635 -0.104 3 0.745
DDR1DDR1 0.635 -0.138 4 0.712
EPHA4EPHA4 0.634 -0.083 2 0.699
FYNFYN 0.633 -0.060 -1 0.679
INSRRINSRR 0.632 -0.130 3 0.683
SRMSSRMS 0.632 -0.158 1 0.312
PDGFRBPDGFRB 0.631 -0.155 3 0.741
FGFR1FGFR1 0.631 -0.085 3 0.688
EPHB1EPHB1 0.630 -0.150 1 0.314
MERTKMERTK 0.630 -0.132 3 0.702
TEKTEK 0.629 -0.069 3 0.672
EPHB2EPHB2 0.629 -0.141 -1 0.651
PDGFRAPDGFRA 0.628 -0.127 3 0.742
EPHB3EPHB3 0.628 -0.149 -1 0.649
TECTEC 0.628 -0.117 -1 0.620
FLT1FLT1 0.627 -0.111 -1 0.676
FRKFRK 0.626 -0.108 -1 0.679
DDR2DDR2 0.625 -0.033 3 0.660
FGFR3FGFR3 0.625 -0.096 3 0.684
MATKMATK 0.625 -0.076 -1 0.624
AXLAXL 0.625 -0.167 3 0.696
BTKBTK 0.624 -0.164 -1 0.643
ALKALK 0.624 -0.133 3 0.663
LYNLYN 0.623 -0.112 3 0.646
EGFREGFR 0.623 -0.091 1 0.252
ERBB2ERBB2 0.622 -0.148 1 0.298
SRCSRC 0.622 -0.098 -1 0.687
EPHA7EPHA7 0.622 -0.111 2 0.692
EPHA1EPHA1 0.622 -0.125 3 0.714
LTKLTK 0.621 -0.151 3 0.671
FGFR4FGFR4 0.621 -0.086 -1 0.644
PTK6PTK6 0.621 -0.183 -1 0.622
PTK2BPTK2B 0.621 -0.101 -1 0.649
CSKCSK 0.620 -0.085 2 0.701
SYKSYK 0.620 -0.079 -1 0.627
EPHA3EPHA3 0.619 -0.140 2 0.667
INSRINSR 0.618 -0.142 3 0.667
FLT4FLT4 0.617 -0.153 3 0.664
NTRK3NTRK3 0.617 -0.141 -1 0.638
PTK2PTK2 0.617 -0.060 -1 0.645
NTRK1NTRK1 0.616 -0.211 -1 0.679
EPHA8EPHA8 0.616 -0.112 -1 0.642
ZAP70ZAP70 0.616 -0.037 -1 0.594
NTRK2NTRK2 0.613 -0.213 3 0.686
EPHA5EPHA5 0.613 -0.145 2 0.677
ERBB4ERBB4 0.610 -0.086 1 0.260
MUSKMUSK 0.610 -0.125 1 0.244
EPHA2EPHA2 0.604 -0.131 -1 0.619
IGF1RIGF1R 0.602 -0.149 3 0.602
FESFES 0.596 -0.125 -1 0.602