Motif 267 (n=233)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A096LP49 | CCDC187 | S519 | ochoa | Coiled-coil domain-containing protein 187 | None |
A1X283 | SH3PXD2B | S291 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
A4D1S0 | KLRG2 | S95 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
C9JH25 | PRRT4 | S724 | ochoa | Proline-rich transmembrane protein 4 | None |
H3BRB1 | None | S238 | ochoa | polynucleotide adenylyltransferase (EC 2.7.7.19) | None |
O00267 | SUPT5H | S867 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
O00268 | TAF4 | S109 | ochoa | Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}. |
O14497 | ARID1A | S382 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
O14526 | FCHO1 | S523 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
O14686 | KMT2D | S477 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S609 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S618 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S654 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S2342 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14813 | PHOX2A | S202 | psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
O14994 | SYN3 | S470 | ochoa|psp | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
O15054 | KDM6B | S799 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
O15164 | TRIM24 | S110 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
O15417 | TNRC18 | S1038 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
O15417 | TNRC18 | S1957 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
O15446 | POLR1G | S136 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
O15503 | INSIG1 | S74 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
O43561 | LAT | S84 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
O43593 | HR | S316 | ochoa | Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}. |
O43734 | TRAF3IP2 | S383 | ochoa | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}. |
O60673 | REV3L | S2183 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
O75030 | MITF | S180 | psp | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
O75369 | FLNB | S440 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S730 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S833 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S932 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1028 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1121 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1316 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1409 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1505 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S1602 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75369 | FLNB | S2274 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75398 | DEAF1 | S176 | ochoa | Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) | Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:0000269|PubMed:11705868, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}. |
O75420 | GIGYF1 | S756 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75808 | CAPN15 | S233 | ochoa | Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) | None |
O75864 | PPP1R37 | S597 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
O95171 | SCEL | S196 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
O95644 | NFATC1 | S403 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
O95785 | WIZ | S1146 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
O96013 | PAK4 | S291 | ochoa|psp | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
P06400 | RB1 | S788 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
P07101 | TH | S62 | psp | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
P08235 | NR3C2 | S703 | ochoa | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}. |
P0C1Z6 | TFPT | S180 | ochoa|psp | TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) | Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
P15336 | ATF2 | S266 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
P21333 | FLNA | S468 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S757 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S860 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S959 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1055 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1343 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1436 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1533 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1630 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1734 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S1946 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21917 | DRD4 | S245 | psp | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}. |
P30414 | NKTR | S613 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
P33076 | CIITA | S288 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
P35568 | IRS1 | S892 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
P42694 | HELZ | S1442 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
P43354 | NR4A2 | S359 | ochoa | Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}. |
P48378 | RFX2 | S28 | ochoa | DNA-binding protein RFX2 (Regulatory factor X 2) | Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}. |
P48382 | RFX5 | S347 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
P48634 | PRRC2A | S1147 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
P48634 | PRRC2A | S1219 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
P48681 | NES | S398 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
P49418 | AMPH | S293 | psp | Amphiphysin | May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. |
P50548 | ERF | S246 | psp | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
P50548 | ERF | S251 | psp | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
P51531 | SMARCA2 | S175 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P51617 | IRAK1 | S173 | psp | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
P52746 | ZNF142 | S1319 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
P54259 | ATN1 | S739 | ochoa|psp | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
P55196 | AFDN | S1455 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
P56945 | BCAR1 | S355 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
P78559 | MAP1A | S2238 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
P98177 | FOXO4 | S230 | ochoa|psp | Forkhead box protein O4 (Fork head domain transcription factor AFX1) | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
Q02086 | SP2 | S78 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
Q03164 | KMT2A | S3036 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q06190 | PPP2R3A | S692 | ochoa | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q08174 | PCDH1 | S962 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
Q12948 | FOXC1 | S241 | ochoa|psp | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
Q13094 | LCP2 | S410 | ochoa|psp | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
Q13118 | KLF10 | S249 | ochoa | Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}. |
Q13322 | GRB10 | S150 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
Q13625 | TP53BP2 | Y874 | psp | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
Q14244 | MAP7 | S365 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
Q14315 | FLNC | S462 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S559 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S954 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1050 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1527 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1624 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1728 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1848 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S1940 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14315 | FLNC | S2395 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14526 | HIC1 | S270 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
Q14676 | MDC1 | S1348 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14676 | MDC1 | S1471 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14676 | MDC1 | S1553 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14699 | RFTN1 | S239 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
Q14934 | NFATC4 | S264 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
Q15654 | TRIP6 | S147 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
Q15797 | SMAD1 | S214 | psp | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
Q16633 | POU2AF1 | S184 | psp | POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1) | Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). {ECO:0000250|UniProtKB:Q64693, ECO:0000269|PubMed:7623806, ECO:0000269|PubMed:7779176, ECO:0000269|PubMed:7859290}. |
Q2NL68 | PROSER3 | S356 | ochoa | Proline and serine-rich protein 3 | None |
Q2TAL5 | SMTNL2 | S101 | ochoa | Smoothelin-like protein 2 | None |
Q3KP66 | INAVA | S313 | ochoa | Innate immunity activator protein | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
Q49AN0 | CRY2 | S558 | ochoa | Cryptochrome-2 | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:Q9R194, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:16790549}. |
Q504T8 | MIDN | S212 | ochoa | Midnolin (Midbrain nucleolar protein) | Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7, ECO:0000269|PubMed:37616343}. |
Q5QP82 | DCAF10 | S92 | ochoa | DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
Q5UE93 | PIK3R6 | S358 | ochoa|psp | Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}. |
Q5VT52 | RPRD2 | S965 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q5VTT5 | MYOM3 | S857 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
Q5VUA4 | ZNF318 | S698 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
Q63HR2 | TNS2 | S975 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
Q63ZY3 | KANK2 | S19 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q68CP9 | ARID2 | S689 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q68EM7 | ARHGAP17 | S762 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
Q6B0I6 | KDM4D | S505 | ochoa | Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:35145029}. |
Q6NYC8 | PPP1R18 | S432 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
Q6PCB5 | RSBN1L | S79 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
Q6XZF7 | DNMBP | S622 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
Q6ZRI6 | C15orf39 | S116 | ochoa | Uncharacterized protein C15orf39 | None |
Q70E73 | RAPH1 | S856 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q70E73 | RAPH1 | S894 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q7L3V2 | RTL10 | S289 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
Q7Z3B3 | KANSL1 | S971 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
Q7Z6G3 | NECAB2 | S57 | ochoa | N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) | May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}. |
Q86T03 | PIP4P1 | S162 | ochoa | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B) | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). {ECO:0000269|PubMed:16365287, ECO:0000269|PubMed:25035345, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:29644770}. |
Q86TI0 | TBC1D1 | S585 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
Q86UU1 | PHLDB1 | S223 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
Q86VM9 | ZC3H18 | S487 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
Q86Y01 | DTX1 | S279 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
Q86YN6 | PPARGC1B | S263 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
Q8IU68 | TMC8 | S683 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
Q8IUW3 | SPATA2L | S252 | ochoa | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | None |
Q8IUW5 | RELL1 | S166 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
Q8IX07 | ZFPM1 | S61 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Q8IX07 | ZFPM1 | S84 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Q8IZL8 | PELP1 | S991 | psp | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
Q8IZP0 | ABI1 | S183 | ochoa|psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
Q8N1G0 | ZNF687 | S183 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
Q8N3F8 | MICALL1 | S323 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8N8E2 | ZNF513 | S253 | ochoa | Zinc finger protein 513 | Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}. |
Q8N8Q3 | ENDOV | S261 | ochoa | Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease) | [Isoform 1]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:25195743, PubMed:27573237, PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:25195743, PubMed:31703097). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746). {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:23912683, ECO:0000269|PubMed:23912718, ECO:0000269|PubMed:25195743, ECO:0000269|PubMed:27573237, ECO:0000269|PubMed:31703097, ECO:0000305}.; FUNCTION: [Isoform 6]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}.; FUNCTION: [Isoform 7]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}. |
Q8TAP9 | MPLKIP | S40 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
Q8TDC3 | BRSK1 | S508 | ochoa | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. |
Q8TE04 | PANK1 | S215 | ochoa | Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) | [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:14523052, ECO:0000269|PubMed:17631502}. |
Q8TEK3 | DOT1L | S834 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8TF74 | WIPF2 | S303 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
Q8WUZ0 | BCL7C | S126 | ochoa | B-cell CLL/lymphoma 7 protein family member C | May play an anti-apoptotic role. {ECO:0000250}. |
Q8WV28 | BLNK | S219 | ochoa | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
Q8WXD9 | CASKIN1 | S719 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q8WXD9 | CASKIN1 | S787 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q8WXD9 | CASKIN1 | S819 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q8WXD9 | CASKIN1 | S1257 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
Q92570 | NR4A3 | S393 | ochoa | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
Q92615 | LARP4B | S524 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
Q96AD5 | PNPLA2 | S476 | ochoa | Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}. |
Q96AP7 | ESAM | S359 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
Q96EZ8 | MCRS1 | S108 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
Q96F45 | ZNF503 | S102 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
Q96HA1 | POM121 | S179 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
Q96JM3 | CHAMP1 | S214 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96KM6 | ZNF512B | S63 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
Q96KQ7 | EHMT2 | S569 | ochoa|psp | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
Q96LB3 | IFT74 | S32 | ochoa | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) | Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}. |
Q96QC0 | PPP1R10 | S337 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
Q99501 | GAS2L1 | S306 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
Q99626 | CDX2 | S283 | ochoa|psp | Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}. |
Q99814 | EPAS1 | S790 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
Q9BRQ0 | PYGO2 | S279 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
Q9BT49 | THAP7 | S210 | ochoa | THAP domain-containing protein 7 | Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000269|PubMed:15561719}. |
Q9BVW5 | TIPIN | S31 | ochoa | TIMELESS-interacting protein | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}. |
Q9BWG6 | SCNM1 | S183 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
Q9BX40 | LSM14B | S115 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
Q9BZL4 | PPP1R12C | S407 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9C000 | NLRP1 | S107 | psp | NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] | Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:27662089, PubMed:31484767, PubMed:33093214, PubMed:33410748, PubMed:33731929, PubMed:33731932, PubMed:35857590). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:12191486, PubMed:17349957, PubMed:22665479). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by some human enteroviruses and rhinoviruses, double-stranded RNA, UV-B irradiation, or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:25562666, PubMed:30096351, PubMed:30291141, PubMed:33093214, PubMed:33243852, PubMed:33410748, PubMed:35857590). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:32051255, PubMed:33093214). In the absence of GSDMD expression, the NLRP1 inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (PubMed:33852854, PubMed:35594856). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses, such as Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). The NLRP1 inflammasome is also activated in response to UV-B irradiation causing ribosome collisions: ribosome collisions cause phosphorylation and activation of NLRP1 in a MAP3K20-dependent manner, leading to pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:11113115, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15212762, ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:22665479, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:25562666, ECO:0000269|PubMed:27662089, ECO:0000269|PubMed:30096351, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31484767, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33243852, ECO:0000269|PubMed:33410748, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856, ECO:0000269|PubMed:35857590}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1]: Constitutes the precursor of the NLRP1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. {ECO:0000269|PubMed:22087307}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, N-terminus]: Regulatory part that prevents formation of the NLRP1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the NLRP1 inflammasome (PubMed:33093214). {ECO:0000269|PubMed:33093214}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Constitutes the active part of the NLRP1 inflammasome (PubMed:33093214, PubMed:33731929, PubMed:33731932). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing this form, which polymerizes and associates with PYCARD/ASC to form of the NLRP1 inflammasome complex: the NLRP1 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:33093214). {ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932}.; FUNCTION: [Isoform 2]: It is unclear whether is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). {ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:22665479}. |
Q9C0C2 | TNKS1BP1 | S369 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0D6 | FHDC1 | S525 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
Q9C0E8 | LNPK | S194 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
Q9C0H5 | ARHGAP39 | S366 | ochoa | Rho GTPase-activating protein 39 | None |
Q9C0K0 | BCL11B | S318 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9C0K0 | BCL11B | S401 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
Q9H0F6 | SHARPIN | S165 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
Q9H2J1 | ARRDC1-AS1 | S71 | ochoa | Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1) | None |
Q9H2Z4 | NKX2-4 | S271 | ochoa | Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D) | Probable transcription factor. |
Q9H3P2 | NELFA | S363 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
Q9H3T3 | SEMA6B | S822 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
Q9H6E5 | TUT1 | S238 | ochoa | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}. |
Q9H6F5 | CCDC86 | S160 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
Q9H7N4 | SCAF1 | S548 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9H7P9 | PLEKHG2 | S450 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
Q9H7S9 | ZNF703 | S78 | ochoa | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. |
Q9H8N7 | ZNF395 | S386 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
Q9HBB8 | CDHR5 | S754 | ochoa | Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) | Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}. |
Q9HC56 | PCDH9 | S932 | ochoa | Protocadherin-9 | Potential calcium-dependent cell-adhesion protein. |
Q9NPC6 | MYOZ2 | S116 | ochoa | Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
Q9NPF5 | DMAP1 | S418 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
Q9NQC3 | RTN4 | S152 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
Q9NRA0 | SPHK2 | S414 | ochoa | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Q9NRY4 | ARHGAP35 | S1451 | ochoa | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
Q9NWQ4 | GPATCH2L | S447 | ochoa | G patch domain-containing protein 2-like | None |
Q9NYQ7 | CELSR3 | S3175 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
Q9P206 | NHSL3 | S612 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9P206 | NHSL3 | S979 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9P275 | USP36 | S546 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
Q9UGJ0 | PRKAG2 | S87 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
Q9UGK3 | STAP2 | S289 | ochoa | Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate) | Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}. |
Q9UHB6 | LIMA1 | S362 | ochoa|psp | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
Q9UJF2 | RASAL2 | S780 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Q9UJM3 | ERRFI1 | S136 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
Q9UK80 | USP21 | S93 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
Q9UKA4 | AKAP11 | S422 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
Q9UL51 | HCN2 | S779 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
Q9ULD5 | ZNF777 | S623 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
Q9ULE3 | DENND2A | S310 | ochoa | DENN domain-containing protein 2A | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}. |
Q9ULM3 | YEATS2 | S447 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
Q9Y3L3 | SH3BP1 | S598 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
Q9Y3X0 | CCDC9 | S386 | ochoa | Coiled-coil domain-containing protein 9 | Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}. |
Q9Y4H2 | IRS2 | S915 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y4R8 | TELO2 | S637 | ochoa | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
Q9Y613 | FHOD1 | S498 | ochoa|psp | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
P46695 | IER3 | S126 | GPS6|EPSD | Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1) | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:22565310}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-4839726 | Chromatin organization | 8.463506e-07 | 6.072 |
R-HSA-3247509 | Chromatin modifying enzymes | 9.751826e-06 | 5.011 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 6.756238e-05 | 4.170 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 6.756238e-05 | 4.170 |
R-HSA-74713 | IRS activation | 1.235207e-04 | 3.908 |
R-HSA-74160 | Gene expression (Transcription) | 1.231189e-04 | 3.910 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 1.749408e-04 | 3.757 |
R-HSA-212165 | Epigenetic regulation of gene expression | 2.336127e-04 | 3.632 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.741463e-04 | 3.562 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.807285e-04 | 3.419 |
R-HSA-212436 | Generic Transcription Pathway | 4.629685e-04 | 3.334 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.585566e-04 | 3.253 |
R-HSA-74749 | Signal attenuation | 7.461479e-04 | 3.127 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.121758e-03 | 2.950 |
R-HSA-73857 | RNA Polymerase II Transcription | 1.178640e-03 | 2.929 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.886587e-03 | 2.724 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.886587e-03 | 2.724 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.197360e-03 | 2.658 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.909836e-03 | 2.536 |
R-HSA-8848021 | Signaling by PTK6 | 2.779392e-03 | 2.556 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.779392e-03 | 2.556 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.704515e-03 | 2.431 |
R-HSA-3214841 | PKMTs methylate histone lysines | 4.084556e-03 | 2.389 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 5.261430e-03 | 2.279 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.768980e-03 | 2.239 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.913817e-03 | 2.228 |
R-HSA-8849473 | PTK6 Expression | 8.054416e-03 | 2.094 |
R-HSA-112412 | SOS-mediated signalling | 8.054416e-03 | 2.094 |
R-HSA-73887 | Death Receptor Signaling | 8.674844e-03 | 2.062 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 9.257480e-03 | 2.034 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.005551e-02 | 1.998 |
R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.320194e-02 | 1.879 |
R-HSA-198203 | PI3K/AKT activation | 1.326250e-02 | 1.877 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.326250e-02 | 1.877 |
R-HSA-2586552 | Signaling by Leptin | 1.326250e-02 | 1.877 |
R-HSA-3214847 | HATs acetylate histones | 1.645423e-02 | 1.784 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 1.566871e-02 | 1.805 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.735447e-02 | 1.761 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.797650e-02 | 1.745 |
R-HSA-167172 | Transcription of the HIV genome | 1.931336e-02 | 1.714 |
R-HSA-209543 | p75NTR recruits signalling complexes | 1.957583e-02 | 1.708 |
R-HSA-114604 | GPVI-mediated activation cascade | 2.021248e-02 | 1.694 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.190955e-02 | 1.659 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.144980e-02 | 1.669 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.272775e-02 | 1.643 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.463721e-02 | 1.608 |
R-HSA-193639 | p75NTR signals via NF-kB | 2.690086e-02 | 1.570 |
R-HSA-1257604 | PIP3 activates AKT signaling | 2.611012e-02 | 1.583 |
R-HSA-446353 | Cell-extracellular matrix interactions | 2.690086e-02 | 1.570 |
R-HSA-3214858 | RMTs methylate histone arginines | 3.280853e-02 | 1.484 |
R-HSA-5633007 | Regulation of TP53 Activity | 3.278955e-02 | 1.484 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 3.605083e-02 | 1.443 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.022010e-02 | 1.396 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.022010e-02 | 1.396 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.022010e-02 | 1.396 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.722952e-02 | 1.429 |
R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 6.429738e-02 | 1.192 |
R-HSA-844455 | The NLRP1 inflammasome | 6.429738e-02 | 1.192 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.429738e-02 | 1.192 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.429738e-02 | 1.192 |
R-HSA-1296061 | HCN channels | 7.665428e-02 | 1.115 |
R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 7.665428e-02 | 1.115 |
R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 8.884875e-02 | 1.051 |
R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 8.884875e-02 | 1.051 |
R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 8.884875e-02 | 1.051 |
R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.008829e-01 | 0.996 |
R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.008829e-01 | 0.996 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 1.127589e-01 | 0.948 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.360444e-01 | 0.866 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 4.112091e-02 | 1.386 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.587216e-01 | 0.799 |
R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.808062e-01 | 0.743 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.916312e-01 | 0.718 |
R-HSA-937039 | IRAK1 recruits IKK complex | 1.916312e-01 | 0.718 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.916312e-01 | 0.718 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 7.201438e-02 | 1.143 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 7.201438e-02 | 1.143 |
R-HSA-167287 | HIV elongation arrest and recovery | 7.580120e-02 | 1.120 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 7.580120e-02 | 1.120 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.023138e-01 | 0.694 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.023138e-01 | 0.694 |
R-HSA-9027284 | Erythropoietin activates RAS | 2.232592e-01 | 0.651 |
R-HSA-5656121 | Translesion synthesis by POLI | 2.335258e-01 | 0.632 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.335258e-01 | 0.632 |
R-HSA-5655862 | Translesion synthesis by POLK | 2.436572e-01 | 0.613 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.536553e-01 | 0.596 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.308042e-02 | 1.200 |
R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 2.635219e-01 | 0.579 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.298837e-01 | 0.886 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 1.298837e-01 | 0.886 |
R-HSA-167161 | HIV Transcription Initiation | 1.388450e-01 | 0.857 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.388450e-01 | 0.857 |
R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 3.109411e-01 | 0.507 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.901252e-01 | 0.721 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.638488e-01 | 0.439 |
R-HSA-9006335 | Signaling by Erythropoietin | 3.722649e-01 | 0.429 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.805701e-01 | 0.420 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.805701e-01 | 0.420 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.887660e-01 | 0.410 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.887660e-01 | 0.410 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.048353e-01 | 0.393 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.048353e-01 | 0.393 |
R-HSA-9856651 | MITF-M-dependent gene expression | 1.862962e-01 | 0.730 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.017068e-01 | 0.520 |
R-HSA-202433 | Generation of second messenger molecules | 1.298837e-01 | 0.886 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 1.298837e-01 | 0.886 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.949133e-01 | 0.710 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.923495e-01 | 0.534 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.246091e-02 | 1.034 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.571450e-01 | 0.804 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 1.254561e-01 | 0.902 |
R-HSA-167169 | HIV Transcription Elongation | 1.298837e-01 | 0.886 |
R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.474580e-01 | 0.831 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.916312e-01 | 0.718 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.553204e-01 | 0.449 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.479364e-01 | 0.830 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.805701e-01 | 0.420 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.826230e-01 | 0.549 |
R-HSA-2424491 | DAP12 signaling | 8.355835e-02 | 1.078 |
R-HSA-8847453 | Synthesis of PIPs in the nucleus | 1.244787e-01 | 0.905 |
R-HSA-2025928 | Calcineurin activates NFAT | 1.474580e-01 | 0.831 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.808062e-01 | 0.743 |
R-HSA-113418 | Formation of the Early Elongation Complex | 7.580120e-02 | 1.120 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.388450e-01 | 0.857 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.433753e-01 | 0.844 |
R-HSA-73864 | RNA Polymerase I Transcription | 3.167806e-01 | 0.499 |
R-HSA-72086 | mRNA Capping | 3.722649e-01 | 0.429 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.462604e-01 | 0.609 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 8.924705e-02 | 1.049 |
R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.698370e-01 | 0.770 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 7.580120e-02 | 1.120 |
R-HSA-110312 | Translesion synthesis by REV1 | 2.232592e-01 | 0.651 |
R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.436572e-01 | 0.613 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 3.968539e-01 | 0.401 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.070501e-01 | 0.513 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.336674e-01 | 0.631 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.298837e-01 | 0.886 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.298837e-01 | 0.886 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.017068e-01 | 0.520 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 3.601113e-01 | 0.444 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.635219e-01 | 0.579 |
R-HSA-201451 | Signaling by BMP | 3.553204e-01 | 0.449 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 8.884875e-02 | 1.051 |
R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.360444e-01 | 0.866 |
R-HSA-9927354 | Co-stimulation by ICOS | 1.360444e-01 | 0.866 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.474580e-01 | 0.831 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.587216e-01 | 0.799 |
R-HSA-209560 | NF-kB is activated and signals survival | 1.808062e-01 | 0.743 |
R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 2.023138e-01 | 0.694 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.023138e-01 | 0.694 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.635219e-01 | 0.579 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 2.732587e-01 | 0.563 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.200537e-01 | 0.495 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 6.381702e-02 | 1.195 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.617120e-01 | 0.791 |
R-HSA-74751 | Insulin receptor signalling cascade | 7.212468e-02 | 1.142 |
R-HSA-111471 | Apoptotic factor-mediated response | 2.635219e-01 | 0.579 |
R-HSA-8849474 | PTK6 Activates STAT3 | 8.884875e-02 | 1.051 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.916312e-01 | 0.718 |
R-HSA-112399 | IRS-mediated signalling | 2.142060e-01 | 0.669 |
R-HSA-75893 | TNF signaling | 5.460569e-02 | 1.263 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.635219e-01 | 0.579 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.466782e-01 | 0.460 |
R-HSA-2428924 | IGF1R signaling cascade | 2.483324e-01 | 0.605 |
R-HSA-9909396 | Circadian clock | 1.360935e-01 | 0.866 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.244787e-01 | 0.905 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.244787e-01 | 0.905 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.474580e-01 | 0.831 |
R-HSA-9761174 | Formation of intermediate mesoderm | 1.587216e-01 | 0.799 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.109411e-01 | 0.507 |
R-HSA-193697 | p75NTR regulates axonogenesis | 1.474580e-01 | 0.831 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.532285e-01 | 0.596 |
R-HSA-2172127 | DAP12 interactions | 1.525268e-01 | 0.817 |
R-HSA-74752 | Signaling by Insulin receptor | 1.553725e-01 | 0.809 |
R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.808062e-01 | 0.743 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.128558e-01 | 0.672 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.923495e-01 | 0.534 |
R-HSA-162587 | HIV Life Cycle | 8.568632e-02 | 1.067 |
R-HSA-9842663 | Signaling by LTK | 1.916312e-01 | 0.718 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.552069e-02 | 1.342 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.466782e-01 | 0.460 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.128558e-01 | 0.672 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.030773e-02 | 1.220 |
R-HSA-2559585 | Oncogene Induced Senescence | 1.081400e-01 | 0.966 |
R-HSA-162906 | HIV Infection | 2.332102e-01 | 0.632 |
R-HSA-390651 | Dopamine receptors | 7.665428e-02 | 1.115 |
R-HSA-8948747 | Regulation of PTEN localization | 1.244787e-01 | 0.905 |
R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.474580e-01 | 0.831 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.808062e-01 | 0.743 |
R-HSA-428540 | Activation of RAC1 | 1.808062e-01 | 0.743 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.023138e-01 | 0.694 |
R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 2.335258e-01 | 0.632 |
R-HSA-9945266 | Differentiation of T cells | 2.335258e-01 | 0.632 |
R-HSA-8941326 | RUNX2 regulates bone development | 1.124062e-01 | 0.949 |
R-HSA-429947 | Deadenylation of mRNA | 3.290464e-01 | 0.483 |
R-HSA-1482801 | Acyl chain remodelling of PS | 3.379207e-01 | 0.471 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 4.048353e-01 | 0.393 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.093642e-01 | 0.679 |
R-HSA-3214842 | HDMs demethylate histones | 6.463589e-02 | 1.190 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 3.313162e-01 | 0.480 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.190584e-01 | 0.659 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.553204e-01 | 0.449 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.581270e-01 | 0.588 |
R-HSA-1592230 | Mitochondrial biogenesis | 2.533317e-01 | 0.596 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.313162e-01 | 0.480 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.638488e-01 | 0.439 |
R-HSA-9613354 | Lipophagy | 1.474580e-01 | 0.831 |
R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 1.698370e-01 | 0.770 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 9.974463e-02 | 1.001 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.017068e-01 | 0.520 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 3.200537e-01 | 0.495 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 3.200537e-01 | 0.495 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 2.287901e-01 | 0.641 |
R-HSA-9930044 | Nuclear RNA decay | 4.048353e-01 | 0.393 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.924075e-01 | 0.534 |
R-HSA-2559583 | Cellular Senescence | 1.277344e-01 | 0.894 |
R-HSA-9842860 | Regulation of endogenous retroelements | 6.519287e-02 | 1.186 |
R-HSA-9627069 | Regulation of the apoptosome activity | 1.587216e-01 | 0.799 |
R-HSA-9675151 | Disorders of Developmental Biology | 2.436572e-01 | 0.613 |
R-HSA-209905 | Catecholamine biosynthesis | 2.536553e-01 | 0.596 |
R-HSA-109704 | PI3K Cascade | 1.805998e-01 | 0.743 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.553204e-01 | 0.449 |
R-HSA-400685 | Sema4D in semaphorin signaling | 3.379207e-01 | 0.471 |
R-HSA-5689880 | Ub-specific processing proteases | 2.529180e-01 | 0.597 |
R-HSA-9733709 | Cardiogenesis | 9.561942e-02 | 1.019 |
R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.244787e-01 | 0.905 |
R-HSA-196783 | Coenzyme A biosynthesis | 2.436572e-01 | 0.613 |
R-HSA-912631 | Regulation of signaling by CBL | 2.732587e-01 | 0.563 |
R-HSA-622312 | Inflammasomes | 3.638488e-01 | 0.439 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.048353e-01 | 0.393 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 3.409593e-01 | 0.467 |
R-HSA-397795 | G-protein beta:gamma signalling | 4.048353e-01 | 0.393 |
R-HSA-450294 | MAP kinase activation | 2.336674e-01 | 0.631 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.722649e-01 | 0.429 |
R-HSA-354192 | Integrin signaling | 4.048353e-01 | 0.393 |
R-HSA-1169408 | ISG15 antiviral mechanism | 3.021748e-01 | 0.520 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.604323e-01 | 0.584 |
R-HSA-448424 | Interleukin-17 signaling | 2.777261e-01 | 0.556 |
R-HSA-430116 | GP1b-IX-V activation signalling | 1.474580e-01 | 0.831 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.483324e-01 | 0.605 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.017068e-01 | 0.520 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.109411e-01 | 0.507 |
R-HSA-114452 | Activation of BH3-only proteins | 3.805701e-01 | 0.420 |
R-HSA-111458 | Formation of apoptosome | 1.587216e-01 | 0.799 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.023138e-01 | 0.694 |
R-HSA-200425 | Carnitine shuttle | 3.200537e-01 | 0.495 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.006641e-01 | 0.997 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 3.528462e-01 | 0.452 |
R-HSA-5689603 | UCH proteinases | 3.070501e-01 | 0.513 |
R-HSA-5688426 | Deubiquitination | 1.618397e-01 | 0.791 |
R-HSA-6807070 | PTEN Regulation | 3.432100e-01 | 0.464 |
R-HSA-8853659 | RET signaling | 1.124062e-01 | 0.949 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.635219e-01 | 0.579 |
R-HSA-9006925 | Intracellular signaling by second messengers | 5.434559e-02 | 1.265 |
R-HSA-9664873 | Pexophagy | 1.587216e-01 | 0.799 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.338465e-01 | 0.873 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.109411e-01 | 0.507 |
R-HSA-9830674 | Formation of the ureteric bud | 3.200537e-01 | 0.495 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.777261e-01 | 0.556 |
R-HSA-8983711 | OAS antiviral response | 1.916312e-01 | 0.718 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.114561e-01 | 0.675 |
R-HSA-186763 | Downstream signal transduction | 3.887660e-01 | 0.410 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.962632e-01 | 0.528 |
R-HSA-9700206 | Signaling by ALK in cancer | 2.114561e-01 | 0.675 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.200537e-01 | 0.495 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 5.753370e-02 | 1.240 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.457649e-01 | 0.461 |
R-HSA-166520 | Signaling by NTRKs | 3.791923e-01 | 0.421 |
R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.023138e-01 | 0.694 |
R-HSA-5675482 | Regulation of necroptotic cell death | 4.048353e-01 | 0.393 |
R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.536553e-01 | 0.596 |
R-HSA-446728 | Cell junction organization | 3.633203e-01 | 0.440 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.005946e-01 | 0.397 |
R-HSA-9671555 | Signaling by PDGFR in disease | 3.017068e-01 | 0.520 |
R-HSA-1266695 | Interleukin-7 signaling | 6.463589e-02 | 1.190 |
R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.128558e-01 | 0.672 |
R-HSA-982772 | Growth hormone receptor signaling | 5.753370e-02 | 1.240 |
R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.732587e-01 | 0.563 |
R-HSA-9663891 | Selective autophagy | 3.696117e-01 | 0.432 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.837569e-01 | 0.416 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.127116e-01 | 0.384 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.127116e-01 | 0.384 |
R-HSA-1482788 | Acyl chain remodelling of PC | 4.127116e-01 | 0.384 |
R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.127116e-01 | 0.384 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.199274e-01 | 0.377 |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.204841e-01 | 0.376 |
R-HSA-180746 | Nuclear import of Rev protein | 4.204841e-01 | 0.376 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.204841e-01 | 0.376 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 4.204841e-01 | 0.376 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.253276e-01 | 0.371 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.253276e-01 | 0.371 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.253276e-01 | 0.371 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.281543e-01 | 0.368 |
R-HSA-1482839 | Acyl chain remodelling of PE | 4.281543e-01 | 0.368 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.431927e-01 | 0.353 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.433368e-01 | 0.353 |
R-HSA-1483255 | PI Metabolism | 4.433368e-01 | 0.353 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.505637e-01 | 0.346 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.505637e-01 | 0.346 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.505637e-01 | 0.346 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.522244e-01 | 0.345 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.578375e-01 | 0.339 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.578375e-01 | 0.339 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.578375e-01 | 0.339 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.578375e-01 | 0.339 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.578375e-01 | 0.339 |
R-HSA-201556 | Signaling by ALK | 4.578375e-01 | 0.339 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.610313e-01 | 0.336 |
R-HSA-5696398 | Nucleotide Excision Repair | 4.610313e-01 | 0.336 |
R-HSA-1500931 | Cell-Cell communication | 4.622218e-01 | 0.335 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.650154e-01 | 0.333 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.650154e-01 | 0.333 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.650154e-01 | 0.333 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.650154e-01 | 0.333 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.667862e-01 | 0.331 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.720988e-01 | 0.326 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 4.720988e-01 | 0.326 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.720988e-01 | 0.326 |
R-HSA-9607240 | FLT3 Signaling | 4.720988e-01 | 0.326 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.720988e-01 | 0.326 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.720988e-01 | 0.326 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.740861e-01 | 0.324 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.783954e-01 | 0.320 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 4.790888e-01 | 0.320 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.790888e-01 | 0.320 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 4.790888e-01 | 0.320 |
R-HSA-202403 | TCR signaling | 4.826832e-01 | 0.316 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.826832e-01 | 0.316 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 4.826832e-01 | 0.316 |
R-HSA-165159 | MTOR signalling | 4.859867e-01 | 0.313 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.859867e-01 | 0.313 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.859867e-01 | 0.313 |
R-HSA-2871796 | FCERI mediated MAPK activation | 4.911936e-01 | 0.309 |
R-HSA-1433557 | Signaling by SCF-KIT | 4.927937e-01 | 0.307 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.954158e-01 | 0.305 |
R-HSA-69231 | Cyclin D associated events in G1 | 4.995109e-01 | 0.301 |
R-HSA-69236 | G1 Phase | 4.995109e-01 | 0.301 |
R-HSA-375280 | Amine ligand-binding receptors | 4.995109e-01 | 0.301 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.996158e-01 | 0.301 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.003364e-01 | 0.301 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 5.036259e-01 | 0.298 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.061396e-01 | 0.296 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.061396e-01 | 0.296 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.079488e-01 | 0.294 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.079488e-01 | 0.294 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.120814e-01 | 0.291 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.126809e-01 | 0.290 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.126809e-01 | 0.290 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.126809e-01 | 0.290 |
R-HSA-2262752 | Cellular responses to stress | 5.179416e-01 | 0.286 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.191360e-01 | 0.285 |
R-HSA-5693538 | Homology Directed Repair | 5.243422e-01 | 0.280 |
R-HSA-5620924 | Intraflagellar transport | 5.255059e-01 | 0.279 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.255059e-01 | 0.279 |
R-HSA-389356 | Co-stimulation by CD28 | 5.255059e-01 | 0.279 |
R-HSA-9031628 | NGF-stimulated transcription | 5.255059e-01 | 0.279 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.255059e-01 | 0.279 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.283832e-01 | 0.277 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.283832e-01 | 0.277 |
R-HSA-73893 | DNA Damage Bypass | 5.317919e-01 | 0.274 |
R-HSA-68875 | Mitotic Prophase | 5.324009e-01 | 0.274 |
R-HSA-5658442 | Regulation of RAS by GAPs | 5.379950e-01 | 0.269 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.403664e-01 | 0.267 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.403664e-01 | 0.267 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.441162e-01 | 0.264 |
R-HSA-9864848 | Complex IV assembly | 5.441162e-01 | 0.264 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.443140e-01 | 0.264 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.501568e-01 | 0.260 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.501568e-01 | 0.260 |
R-HSA-6794361 | Neurexins and neuroligins | 5.501568e-01 | 0.260 |
R-HSA-194138 | Signaling by VEGF | 5.560153e-01 | 0.255 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.561176e-01 | 0.255 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.561176e-01 | 0.255 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 5.561176e-01 | 0.255 |
R-HSA-389948 | Co-inhibition by PD-1 | 5.578748e-01 | 0.253 |
R-HSA-72649 | Translation initiation complex formation | 5.619999e-01 | 0.250 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.619999e-01 | 0.250 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.670763e-01 | 0.246 |
R-HSA-376176 | Signaling by ROBO receptors | 5.670763e-01 | 0.246 |
R-HSA-73894 | DNA Repair | 5.704145e-01 | 0.244 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.735326e-01 | 0.241 |
R-HSA-193648 | NRAGE signals death through JNK | 5.735326e-01 | 0.241 |
R-HSA-209776 | Metabolism of amine-derived hormones | 5.735326e-01 | 0.241 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 5.791851e-01 | 0.237 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.791851e-01 | 0.237 |
R-HSA-9843745 | Adipogenesis | 5.824862e-01 | 0.235 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.847631e-01 | 0.233 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.847631e-01 | 0.233 |
R-HSA-5673001 | RAF/MAP kinase cascade | 5.890820e-01 | 0.230 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.902674e-01 | 0.229 |
R-HSA-194441 | Metabolism of non-coding RNA | 5.902674e-01 | 0.229 |
R-HSA-191859 | snRNP Assembly | 5.902674e-01 | 0.229 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.902674e-01 | 0.229 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.956991e-01 | 0.225 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 6.010592e-01 | 0.221 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.010592e-01 | 0.221 |
R-HSA-1483257 | Phospholipid metabolism | 6.042118e-01 | 0.219 |
R-HSA-6784531 | tRNA processing in the nucleus | 6.063485e-01 | 0.217 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.063485e-01 | 0.217 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.063485e-01 | 0.217 |
R-HSA-9707616 | Heme signaling | 6.063485e-01 | 0.217 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.063485e-01 | 0.217 |
R-HSA-186797 | Signaling by PDGF | 6.063485e-01 | 0.217 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.067007e-01 | 0.217 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.115680e-01 | 0.214 |
R-HSA-373755 | Semaphorin interactions | 6.115680e-01 | 0.214 |
R-HSA-195721 | Signaling by WNT | 6.116502e-01 | 0.213 |
R-HSA-418990 | Adherens junctions interactions | 6.141299e-01 | 0.212 |
R-HSA-9664417 | Leishmania phagocytosis | 6.182648e-01 | 0.209 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.182648e-01 | 0.209 |
R-HSA-9664407 | Parasite infection | 6.182648e-01 | 0.209 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.217107e-01 | 0.206 |
R-HSA-1632852 | Macroautophagy | 6.217107e-01 | 0.206 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.218012e-01 | 0.206 |
R-HSA-1234174 | Cellular response to hypoxia | 6.218012e-01 | 0.206 |
R-HSA-913531 | Interferon Signaling | 6.245076e-01 | 0.204 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.285309e-01 | 0.202 |
R-HSA-162582 | Signal Transduction | 6.316685e-01 | 0.200 |
R-HSA-5693606 | DNA Double Strand Break Response | 6.317661e-01 | 0.199 |
R-HSA-9830369 | Kidney development | 6.317661e-01 | 0.199 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 6.319051e-01 | 0.199 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.366501e-01 | 0.196 |
R-HSA-5218859 | Regulated Necrosis | 6.366501e-01 | 0.196 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 6.417492e-01 | 0.193 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.462255e-01 | 0.190 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.462255e-01 | 0.190 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 6.484197e-01 | 0.188 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.509186e-01 | 0.186 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.509186e-01 | 0.186 |
R-HSA-453276 | Regulation of mitotic cell cycle | 6.509186e-01 | 0.186 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.555497e-01 | 0.183 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.555497e-01 | 0.183 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.555497e-01 | 0.183 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.601197e-01 | 0.180 |
R-HSA-4086398 | Ca2+ pathway | 6.601197e-01 | 0.180 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.601197e-01 | 0.180 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 6.635190e-01 | 0.178 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 6.643443e-01 | 0.178 |
R-HSA-69473 | G2/M DNA damage checkpoint | 6.646293e-01 | 0.177 |
R-HSA-1226099 | Signaling by FGFR in disease | 6.646293e-01 | 0.177 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.690794e-01 | 0.175 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.705504e-01 | 0.174 |
R-HSA-1980143 | Signaling by NOTCH1 | 6.734707e-01 | 0.172 |
R-HSA-9612973 | Autophagy | 6.736187e-01 | 0.172 |
R-HSA-9610379 | HCMV Late Events | 6.766639e-01 | 0.170 |
R-HSA-9711097 | Cellular response to starvation | 6.796860e-01 | 0.168 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.796860e-01 | 0.168 |
R-HSA-416482 | G alpha (12/13) signalling events | 6.820800e-01 | 0.166 |
R-HSA-877300 | Interferon gamma signaling | 6.826851e-01 | 0.166 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.862995e-01 | 0.163 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.904633e-01 | 0.161 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.904633e-01 | 0.161 |
R-HSA-8953897 | Cellular responses to stimuli | 6.909044e-01 | 0.161 |
R-HSA-109581 | Apoptosis | 6.915456e-01 | 0.160 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.986266e-01 | 0.156 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.986266e-01 | 0.156 |
R-HSA-421270 | Cell-cell junction organization | 6.999119e-01 | 0.155 |
R-HSA-1266738 | Developmental Biology | 7.037509e-01 | 0.153 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.065756e-01 | 0.151 |
R-HSA-6802957 | Oncogenic MAPK signaling | 7.104715e-01 | 0.148 |
R-HSA-6794362 | Protein-protein interactions at synapses | 7.104715e-01 | 0.148 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.143159e-01 | 0.146 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.143159e-01 | 0.146 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.169132e-01 | 0.145 |
R-HSA-5683057 | MAPK family signaling cascades | 7.205016e-01 | 0.142 |
R-HSA-438064 | Post NMDA receptor activation events | 7.218529e-01 | 0.142 |
R-HSA-9694516 | SARS-CoV-2 Infection | 7.244262e-01 | 0.140 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.249727e-01 | 0.140 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.249727e-01 | 0.140 |
R-HSA-156902 | Peptide chain elongation | 7.255469e-01 | 0.139 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.276159e-01 | 0.138 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.302378e-01 | 0.137 |
R-HSA-9678108 | SARS-CoV-1 Infection | 7.302378e-01 | 0.137 |
R-HSA-112310 | Neurotransmitter release cycle | 7.327889e-01 | 0.135 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.363383e-01 | 0.133 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.398408e-01 | 0.131 |
R-HSA-168255 | Influenza Infection | 7.405128e-01 | 0.130 |
R-HSA-156842 | Eukaryotic Translation Elongation | 7.432969e-01 | 0.129 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.467073e-01 | 0.127 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.533935e-01 | 0.123 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 7.566704e-01 | 0.121 |
R-HSA-72764 | Eukaryotic Translation Termination | 7.566704e-01 | 0.121 |
R-HSA-1296071 | Potassium Channels | 7.599040e-01 | 0.119 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.599040e-01 | 0.119 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.624186e-01 | 0.118 |
R-HSA-422475 | Axon guidance | 7.658350e-01 | 0.116 |
R-HSA-8957275 | Post-translational protein phosphorylation | 7.662434e-01 | 0.116 |
R-HSA-9614085 | FOXO-mediated transcription | 7.693503e-01 | 0.114 |
R-HSA-168898 | Toll-like Receptor Cascades | 7.693578e-01 | 0.114 |
R-HSA-70171 | Glycolysis | 7.724161e-01 | 0.112 |
R-HSA-9020702 | Interleukin-1 signaling | 7.754414e-01 | 0.110 |
R-HSA-2408557 | Selenocysteine synthesis | 7.754414e-01 | 0.110 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.784266e-01 | 0.109 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.784266e-01 | 0.109 |
R-HSA-9609690 | HCMV Early Events | 7.805330e-01 | 0.108 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.805330e-01 | 0.108 |
R-HSA-192823 | Viral mRNA Translation | 7.813724e-01 | 0.107 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.842791e-01 | 0.106 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 7.871474e-01 | 0.104 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.871474e-01 | 0.104 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 7.927706e-01 | 0.101 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.953832e-01 | 0.099 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.955265e-01 | 0.099 |
R-HSA-211000 | Gene Silencing by RNA | 7.955265e-01 | 0.099 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.982459e-01 | 0.098 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.982459e-01 | 0.098 |
R-HSA-5357801 | Programmed Cell Death | 8.014723e-01 | 0.096 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.087682e-01 | 0.092 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.087682e-01 | 0.092 |
R-HSA-1483249 | Inositol phosphate metabolism | 8.087682e-01 | 0.092 |
R-HSA-9675108 | Nervous system development | 8.152217e-01 | 0.089 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.162999e-01 | 0.088 |
R-HSA-72737 | Cap-dependent Translation Initiation | 8.235362e-01 | 0.084 |
R-HSA-72613 | Eukaryotic Translation Initiation | 8.235362e-01 | 0.084 |
R-HSA-70326 | Glucose metabolism | 8.258847e-01 | 0.083 |
R-HSA-9007101 | Rab regulation of trafficking | 8.258847e-01 | 0.083 |
R-HSA-2980736 | Peptide hormone metabolism | 8.258847e-01 | 0.083 |
R-HSA-8951664 | Neddylation | 8.313134e-01 | 0.080 |
R-HSA-3371556 | Cellular response to heat stress | 8.349717e-01 | 0.078 |
R-HSA-162909 | Host Interactions of HIV factors | 8.414757e-01 | 0.075 |
R-HSA-109582 | Hemostasis | 8.429843e-01 | 0.074 |
R-HSA-69206 | G1/S Transition | 8.456693e-01 | 0.073 |
R-HSA-72312 | rRNA processing | 8.494291e-01 | 0.071 |
R-HSA-114608 | Platelet degranulation | 8.497525e-01 | 0.071 |
R-HSA-69481 | G2/M Checkpoints | 8.497525e-01 | 0.071 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.500131e-01 | 0.071 |
R-HSA-1474228 | Degradation of the extracellular matrix | 8.613680e-01 | 0.065 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.632151e-01 | 0.064 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 8.669838e-01 | 0.062 |
R-HSA-163685 | Integration of energy metabolism | 8.703617e-01 | 0.060 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.703617e-01 | 0.060 |
R-HSA-9018519 | Estrogen-dependent gene expression | 8.703617e-01 | 0.060 |
R-HSA-9948299 | Ribosome-associated quality control | 8.737943e-01 | 0.059 |
R-HSA-9609646 | HCMV Infection | 8.753004e-01 | 0.058 |
R-HSA-9679506 | SARS-CoV Infections | 8.832895e-01 | 0.054 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.881553e-01 | 0.052 |
R-HSA-69242 | S Phase | 8.911188e-01 | 0.050 |
R-HSA-112316 | Neuronal System | 8.917318e-01 | 0.050 |
R-HSA-9758941 | Gastrulation | 8.925711e-01 | 0.049 |
R-HSA-9679191 | Potential therapeutics for SARS | 8.940042e-01 | 0.049 |
R-HSA-446652 | Interleukin-1 family signaling | 8.968134e-01 | 0.047 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.968134e-01 | 0.047 |
R-HSA-9711123 | Cellular response to chemical stress | 8.970350e-01 | 0.047 |
R-HSA-1989781 | PPARA activates gene expression | 9.008889e-01 | 0.045 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.035165e-01 | 0.044 |
R-HSA-9006936 | Signaling by TGFB family members | 9.073284e-01 | 0.042 |
R-HSA-9658195 | Leishmania infection | 9.104892e-01 | 0.041 |
R-HSA-9824443 | Parasitic Infection Pathways | 9.104892e-01 | 0.041 |
R-HSA-2408522 | Selenoamino acid metabolism | 9.121788e-01 | 0.040 |
R-HSA-5619102 | SLC transporter disorders | 9.156499e-01 | 0.038 |
R-HSA-72306 | tRNA processing | 9.200667e-01 | 0.036 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 9.211344e-01 | 0.036 |
R-HSA-611105 | Respiratory electron transport | 9.282213e-01 | 0.032 |
R-HSA-449147 | Signaling by Interleukins | 9.332148e-01 | 0.030 |
R-HSA-5617833 | Cilium Assembly | 9.389265e-01 | 0.027 |
R-HSA-112315 | Transmission across Chemical Synapses | 9.435584e-01 | 0.025 |
R-HSA-9824446 | Viral Infection Pathways | 9.445739e-01 | 0.025 |
R-HSA-199991 | Membrane Trafficking | 9.448754e-01 | 0.025 |
R-HSA-428157 | Sphingolipid metabolism | 9.473366e-01 | 0.023 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.552014e-01 | 0.020 |
R-HSA-68882 | Mitotic Anaphase | 9.575539e-01 | 0.019 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.581225e-01 | 0.019 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.648602e-01 | 0.016 |
R-HSA-597592 | Post-translational protein modification | 9.660210e-01 | 0.015 |
R-HSA-8939211 | ESR-mediated signaling | 9.680293e-01 | 0.014 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 9.680293e-01 | 0.014 |
R-HSA-157118 | Signaling by NOTCH | 9.692988e-01 | 0.014 |
R-HSA-68886 | M Phase | 9.713631e-01 | 0.013 |
R-HSA-5619115 | Disorders of transmembrane transporters | 9.720693e-01 | 0.012 |
R-HSA-8953854 | Metabolism of RNA | 9.731397e-01 | 0.012 |
R-HSA-1280218 | Adaptive Immune System | 9.750927e-01 | 0.011 |
R-HSA-69620 | Cell Cycle Checkpoints | 9.759286e-01 | 0.011 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.818829e-01 | 0.008 |
R-HSA-5653656 | Vesicle-mediated transport | 9.868463e-01 | 0.006 |
R-HSA-8957322 | Metabolism of steroids | 9.901581e-01 | 0.004 |
R-HSA-1474244 | Extracellular matrix organization | 9.910507e-01 | 0.004 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.921879e-01 | 0.003 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 9.942085e-01 | 0.003 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.942868e-01 | 0.002 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.962554e-01 | 0.002 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.964055e-01 | 0.002 |
R-HSA-5663205 | Infectious disease | 9.965099e-01 | 0.002 |
R-HSA-69278 | Cell Cycle, Mitotic | 9.967814e-01 | 0.001 |
R-HSA-418594 | G alpha (i) signalling events | 9.968641e-01 | 0.001 |
R-HSA-8978868 | Fatty acid metabolism | 9.968641e-01 | 0.001 |
R-HSA-1640170 | Cell Cycle | 9.969135e-01 | 0.001 |
R-HSA-72766 | Translation | 9.976782e-01 | 0.001 |
R-HSA-168249 | Innate Immune System | 9.978027e-01 | 0.001 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.983020e-01 | 0.001 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.983732e-01 | 0.001 |
R-HSA-388396 | GPCR downstream signalling | 9.985503e-01 | 0.001 |
R-HSA-168256 | Immune System | 9.986205e-01 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 9.994324e-01 | 0.000 |
R-HSA-372790 | Signaling by GPCR | 9.994514e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 9.995181e-01 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 9.997424e-01 | 0.000 |
R-HSA-1643685 | Disease | 9.998086e-01 | 0.000 |
R-HSA-382551 | Transport of small molecules | 9.999989e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.802 | 0.698 | 1 | 0.853 |
CDK19 |
0.795 | 0.750 | 1 | 0.848 |
CDK18 |
0.790 | 0.711 | 1 | 0.869 |
CDK8 |
0.785 | 0.740 | 1 | 0.814 |
P38B |
0.785 | 0.779 | 1 | 0.837 |
P38D |
0.783 | 0.702 | 1 | 0.901 |
ERK1 |
0.783 | 0.743 | 1 | 0.852 |
KIS |
0.783 | 0.569 | 1 | 0.795 |
MAK |
0.783 | 0.709 | -2 | 0.759 |
CDK17 |
0.780 | 0.684 | 1 | 0.895 |
P38G |
0.780 | 0.690 | 1 | 0.903 |
HIPK4 |
0.777 | 0.625 | 1 | 0.560 |
CDK7 |
0.776 | 0.698 | 1 | 0.822 |
CDK3 |
0.773 | 0.588 | 1 | 0.890 |
DYRK2 |
0.772 | 0.643 | 1 | 0.772 |
CDK1 |
0.772 | 0.654 | 1 | 0.850 |
JNK2 |
0.770 | 0.678 | 1 | 0.863 |
DYRK4 |
0.768 | 0.615 | 1 | 0.862 |
CDK16 |
0.768 | 0.655 | 1 | 0.883 |
P38A |
0.767 | 0.762 | 1 | 0.772 |
CDK5 |
0.766 | 0.649 | 1 | 0.797 |
CDK13 |
0.765 | 0.622 | 1 | 0.843 |
CDK12 |
0.764 | 0.622 | 1 | 0.862 |
HIPK1 |
0.762 | 0.581 | 1 | 0.753 |
DYRK1A |
0.761 | 0.604 | 1 | 0.729 |
JNK3 |
0.756 | 0.648 | 1 | 0.837 |
DYRK1B |
0.756 | 0.576 | 1 | 0.820 |
CDK14 |
0.755 | 0.629 | 1 | 0.830 |
CDK9 |
0.752 | 0.591 | 1 | 0.836 |
HIPK3 |
0.752 | 0.573 | 1 | 0.721 |
CDK10 |
0.751 | 0.576 | 1 | 0.847 |
ERK2 |
0.748 | 0.655 | 1 | 0.806 |
CLK3 |
0.747 | 0.438 | 1 | 0.524 |
CDK4 |
0.746 | 0.626 | 1 | 0.868 |
JNK1 |
0.745 | 0.589 | 1 | 0.863 |
CDK6 |
0.744 | 0.595 | 1 | 0.846 |
MOK |
0.744 | 0.566 | 1 | 0.651 |
ICK |
0.743 | 0.577 | -3 | 0.824 |
CDKL5 |
0.738 | 0.394 | -3 | 0.797 |
DYRK3 |
0.737 | 0.440 | 1 | 0.716 |
SRPK1 |
0.736 | 0.289 | -3 | 0.770 |
ERK5 |
0.731 | 0.389 | 1 | 0.487 |
NLK |
0.731 | 0.543 | 1 | 0.563 |
CDK2 |
0.726 | 0.437 | 1 | 0.731 |
SRPK2 |
0.725 | 0.243 | -3 | 0.695 |
CLK2 |
0.722 | 0.293 | -3 | 0.755 |
CDKL1 |
0.720 | 0.314 | -3 | 0.799 |
PRP4 |
0.715 | 0.385 | -3 | 0.754 |
CLK1 |
0.714 | 0.279 | -3 | 0.747 |
MTOR |
0.713 | 0.226 | 1 | 0.357 |
CLK4 |
0.711 | 0.251 | -3 | 0.762 |
NDR2 |
0.706 | 0.093 | -3 | 0.803 |
SRPK3 |
0.705 | 0.185 | -3 | 0.733 |
MPSK1 |
0.705 | 0.321 | 1 | 0.247 |
CHAK2 |
0.704 | 0.090 | -1 | 0.796 |
AURC |
0.701 | 0.016 | -2 | 0.210 |
COT |
0.701 | -0.057 | 2 | 0.818 |
CDC7 |
0.701 | 0.013 | 1 | 0.192 |
TBK1 |
0.700 | 0.004 | 1 | 0.144 |
PIM3 |
0.700 | 0.032 | -3 | 0.814 |
MOS |
0.699 | 0.068 | 1 | 0.234 |
ATR |
0.698 | 0.040 | 1 | 0.235 |
ERK7 |
0.697 | 0.231 | 2 | 0.528 |
GRK1 |
0.695 | 0.034 | -2 | 0.294 |
PRPK |
0.694 | 0.013 | -1 | 0.811 |
SKMLCK |
0.694 | 0.021 | -2 | 0.322 |
PRKD1 |
0.694 | 0.000 | -3 | 0.800 |
GRK7 |
0.691 | 0.072 | 1 | 0.208 |
IKKE |
0.690 | -0.085 | 1 | 0.141 |
IKKB |
0.690 | -0.155 | -2 | 0.229 |
IKKA |
0.689 | -0.046 | -2 | 0.253 |
PRKD2 |
0.688 | -0.008 | -3 | 0.766 |
NDR1 |
0.687 | -0.028 | -3 | 0.798 |
PKACB |
0.686 | -0.001 | -2 | 0.201 |
MLK2 |
0.686 | 0.086 | 2 | 0.795 |
PKACG |
0.686 | -0.041 | -2 | 0.238 |
PAK1 |
0.686 | -0.006 | -2 | 0.319 |
PDHK4 |
0.685 | -0.108 | 1 | 0.239 |
WNK1 |
0.684 | -0.052 | -2 | 0.345 |
CAMK1B |
0.684 | -0.057 | -3 | 0.830 |
GCN2 |
0.683 | -0.179 | 2 | 0.786 |
PIM1 |
0.683 | 0.014 | -3 | 0.776 |
MNK2 |
0.683 | -0.014 | -2 | 0.258 |
RAF1 |
0.683 | -0.147 | 1 | 0.172 |
MARK4 |
0.683 | -0.037 | 4 | 0.838 |
PAK6 |
0.682 | -0.021 | -2 | 0.239 |
RSK2 |
0.682 | -0.020 | -3 | 0.778 |
LATS2 |
0.682 | -0.010 | -5 | 0.737 |
CAMLCK |
0.682 | -0.018 | -2 | 0.290 |
PAK3 |
0.682 | -0.038 | -2 | 0.292 |
ULK2 |
0.682 | -0.167 | 2 | 0.795 |
MLK3 |
0.681 | 0.060 | 2 | 0.700 |
NUAK2 |
0.681 | -0.022 | -3 | 0.818 |
P90RSK |
0.681 | -0.005 | -3 | 0.775 |
BMPR2 |
0.681 | -0.154 | -2 | 0.287 |
TGFBR2 |
0.681 | -0.114 | -2 | 0.219 |
PKG2 |
0.680 | -0.028 | -2 | 0.213 |
PRKX |
0.680 | 0.010 | -3 | 0.694 |
PKCD |
0.680 | -0.017 | 2 | 0.746 |
DAPK2 |
0.680 | -0.028 | -3 | 0.828 |
PDHK1 |
0.680 | -0.132 | 1 | 0.211 |
RSK3 |
0.679 | -0.026 | -3 | 0.764 |
MST4 |
0.679 | -0.066 | 2 | 0.787 |
PKN3 |
0.679 | -0.050 | -3 | 0.797 |
NEK6 |
0.679 | -0.093 | -2 | 0.252 |
NIK |
0.679 | -0.075 | -3 | 0.823 |
AMPKA1 |
0.678 | -0.038 | -3 | 0.815 |
IRE1 |
0.678 | -0.033 | 1 | 0.178 |
GRK5 |
0.677 | -0.118 | -3 | 0.790 |
AMPKA2 |
0.677 | -0.011 | -3 | 0.792 |
MASTL |
0.677 | -0.106 | -2 | 0.285 |
MAPKAPK2 |
0.677 | -0.017 | -3 | 0.727 |
AURB |
0.677 | -0.043 | -2 | 0.202 |
NIM1 |
0.676 | -0.070 | 3 | 0.704 |
MAPKAPK3 |
0.676 | -0.049 | -3 | 0.752 |
MNK1 |
0.676 | -0.023 | -2 | 0.258 |
RIPK3 |
0.676 | -0.069 | 3 | 0.667 |
PKCZ |
0.676 | 0.007 | 2 | 0.765 |
PKCA |
0.676 | 0.015 | 2 | 0.690 |
GSK3A |
0.676 | 0.169 | 4 | 0.405 |
LATS1 |
0.675 | 0.042 | -3 | 0.809 |
RSK4 |
0.675 | 0.017 | -3 | 0.749 |
MLK1 |
0.674 | -0.081 | 2 | 0.768 |
CAMK2G |
0.674 | -0.121 | 2 | 0.789 |
QSK |
0.673 | -0.019 | 4 | 0.818 |
PKN2 |
0.673 | -0.095 | -3 | 0.801 |
TSSK1 |
0.673 | -0.052 | -3 | 0.835 |
P70S6KB |
0.673 | -0.038 | -3 | 0.776 |
WNK3 |
0.673 | -0.131 | 1 | 0.173 |
PKCG |
0.673 | -0.019 | 2 | 0.705 |
SGK3 |
0.672 | -0.014 | -3 | 0.757 |
SMG1 |
0.672 | -0.042 | 1 | 0.220 |
PRKD3 |
0.672 | -0.031 | -3 | 0.741 |
PHKG1 |
0.672 | -0.039 | -3 | 0.787 |
CAMK2D |
0.672 | -0.090 | -3 | 0.800 |
VRK2 |
0.672 | 0.108 | 1 | 0.279 |
AKT2 |
0.672 | 0.007 | -3 | 0.708 |
PAK2 |
0.671 | -0.052 | -2 | 0.299 |
BCKDK |
0.671 | -0.118 | -1 | 0.731 |
PKCB |
0.671 | -0.023 | 2 | 0.684 |
CHAK1 |
0.671 | -0.052 | 2 | 0.842 |
BMPR1B |
0.671 | -0.081 | 1 | 0.166 |
ULK1 |
0.670 | -0.161 | -3 | 0.719 |
PINK1 |
0.670 | 0.050 | 1 | 0.389 |
PKACA |
0.669 | -0.021 | -2 | 0.180 |
DLK |
0.669 | -0.112 | 1 | 0.187 |
DSTYK |
0.669 | -0.238 | 2 | 0.824 |
TGFBR1 |
0.669 | -0.082 | -2 | 0.238 |
TTBK2 |
0.668 | -0.130 | 2 | 0.753 |
ALK4 |
0.668 | -0.094 | -2 | 0.252 |
NUAK1 |
0.667 | -0.043 | -3 | 0.759 |
MSK2 |
0.667 | -0.047 | -3 | 0.741 |
PIM2 |
0.667 | 0.001 | -3 | 0.747 |
PAK5 |
0.667 | -0.042 | -2 | 0.234 |
BRSK2 |
0.667 | -0.030 | -3 | 0.773 |
SIK |
0.667 | -0.037 | -3 | 0.732 |
NEK7 |
0.667 | -0.230 | -3 | 0.741 |
RIPK1 |
0.667 | -0.139 | 1 | 0.172 |
DNAPK |
0.667 | -0.036 | 1 | 0.218 |
MELK |
0.667 | -0.075 | -3 | 0.772 |
TLK2 |
0.666 | -0.087 | 1 | 0.164 |
AURA |
0.666 | -0.062 | -2 | 0.188 |
CK1E |
0.666 | 0.001 | -3 | 0.529 |
IRE2 |
0.666 | -0.044 | 2 | 0.736 |
BUB1 |
0.666 | 0.072 | -5 | 0.736 |
NEK9 |
0.665 | -0.164 | 2 | 0.811 |
TSSK2 |
0.665 | -0.130 | -5 | 0.790 |
MARK3 |
0.665 | -0.036 | 4 | 0.781 |
PKR |
0.664 | -0.075 | 1 | 0.195 |
MSK1 |
0.664 | -0.039 | -3 | 0.744 |
PAK4 |
0.664 | -0.035 | -2 | 0.239 |
BRSK1 |
0.664 | -0.033 | -3 | 0.761 |
QIK |
0.663 | -0.111 | -3 | 0.789 |
CAMK2A |
0.663 | -0.025 | 2 | 0.744 |
ATM |
0.663 | -0.080 | 1 | 0.201 |
PLK4 |
0.663 | -0.095 | 2 | 0.696 |
HUNK |
0.663 | -0.211 | 2 | 0.801 |
MLK4 |
0.663 | -0.030 | 2 | 0.690 |
AKT1 |
0.663 | -0.018 | -3 | 0.719 |
DCAMKL1 |
0.662 | -0.041 | -3 | 0.764 |
GRK2 |
0.662 | -0.090 | -2 | 0.240 |
GRK4 |
0.661 | -0.168 | -2 | 0.267 |
PKCH |
0.661 | -0.064 | 2 | 0.692 |
YSK4 |
0.661 | -0.137 | 1 | 0.154 |
TAO3 |
0.660 | 0.004 | 1 | 0.203 |
MYLK4 |
0.659 | -0.074 | -2 | 0.242 |
GRK6 |
0.659 | -0.171 | 1 | 0.175 |
MARK2 |
0.658 | -0.061 | 4 | 0.755 |
MAP3K15 |
0.658 | 0.056 | 1 | 0.177 |
MEK1 |
0.658 | -0.163 | 2 | 0.820 |
AKT3 |
0.658 | 0.002 | -3 | 0.662 |
CAMK4 |
0.658 | -0.150 | -3 | 0.779 |
ANKRD3 |
0.658 | -0.231 | 1 | 0.194 |
PASK |
0.658 | 0.020 | -3 | 0.829 |
FAM20C |
0.657 | -0.035 | 2 | 0.574 |
ACVR2B |
0.657 | -0.134 | -2 | 0.221 |
CAMK2B |
0.657 | -0.084 | 2 | 0.740 |
WNK4 |
0.656 | -0.076 | -2 | 0.349 |
IRAK4 |
0.656 | -0.073 | 1 | 0.158 |
ACVR2A |
0.656 | -0.143 | -2 | 0.211 |
CK1D |
0.656 | -0.015 | -3 | 0.482 |
MST3 |
0.655 | -0.065 | 2 | 0.790 |
LKB1 |
0.655 | 0.000 | -3 | 0.747 |
PDK1 |
0.655 | -0.023 | 1 | 0.212 |
NEK2 |
0.655 | -0.155 | 2 | 0.806 |
SNRK |
0.654 | -0.134 | 2 | 0.761 |
PKCT |
0.654 | -0.066 | 2 | 0.702 |
SSTK |
0.654 | -0.084 | 4 | 0.812 |
PLK1 |
0.653 | -0.196 | -2 | 0.215 |
SGK1 |
0.653 | 0.019 | -3 | 0.643 |
MEK5 |
0.652 | -0.135 | 2 | 0.811 |
PHKG2 |
0.652 | -0.092 | -3 | 0.774 |
DCAMKL2 |
0.652 | -0.056 | -3 | 0.781 |
MAPKAPK5 |
0.651 | -0.099 | -3 | 0.698 |
CK1G1 |
0.651 | -0.057 | -3 | 0.509 |
GSK3B |
0.651 | 0.029 | 4 | 0.398 |
PKCI |
0.651 | -0.064 | 2 | 0.723 |
CHK1 |
0.651 | -0.104 | -3 | 0.773 |
PKCE |
0.651 | -0.026 | 2 | 0.690 |
PBK |
0.651 | 0.006 | 1 | 0.217 |
MEKK2 |
0.651 | -0.116 | 2 | 0.786 |
MARK1 |
0.650 | -0.088 | 4 | 0.795 |
PERK |
0.650 | -0.170 | -2 | 0.239 |
ALK2 |
0.650 | -0.136 | -2 | 0.232 |
SBK |
0.649 | 0.063 | -3 | 0.610 |
GRK3 |
0.649 | -0.098 | -2 | 0.220 |
ZAK |
0.649 | -0.150 | 1 | 0.164 |
MEKK1 |
0.649 | -0.139 | 1 | 0.181 |
HASPIN |
0.648 | 0.055 | -1 | 0.699 |
CAMK1G |
0.648 | -0.086 | -3 | 0.746 |
NEK5 |
0.648 | -0.126 | 1 | 0.177 |
BMPR1A |
0.648 | -0.110 | 1 | 0.152 |
DRAK1 |
0.648 | -0.141 | 1 | 0.164 |
MEKK6 |
0.648 | -0.045 | 1 | 0.184 |
GCK |
0.647 | -0.019 | 1 | 0.184 |
P70S6K |
0.647 | -0.058 | -3 | 0.703 |
ROCK2 |
0.646 | -0.007 | -3 | 0.767 |
KHS1 |
0.646 | 0.005 | 1 | 0.174 |
CK1A2 |
0.646 | -0.038 | -3 | 0.485 |
SMMLCK |
0.646 | -0.081 | -3 | 0.797 |
HGK |
0.645 | -0.052 | 3 | 0.846 |
MRCKB |
0.645 | -0.027 | -3 | 0.731 |
BRAF |
0.645 | -0.163 | -4 | 0.536 |
TAO2 |
0.645 | -0.059 | 2 | 0.811 |
TNIK |
0.645 | -0.030 | 3 | 0.853 |
LRRK2 |
0.645 | -0.001 | 2 | 0.843 |
SLK |
0.643 | -0.035 | -2 | 0.246 |
PLK3 |
0.643 | -0.156 | 2 | 0.771 |
NEK11 |
0.643 | -0.103 | 1 | 0.198 |
LOK |
0.643 | -0.064 | -2 | 0.242 |
TLK1 |
0.643 | -0.188 | -2 | 0.245 |
PKG1 |
0.643 | -0.063 | -2 | 0.159 |
TTBK1 |
0.643 | -0.128 | 2 | 0.692 |
HRI |
0.643 | -0.198 | -2 | 0.256 |
DAPK3 |
0.642 | -0.064 | -3 | 0.781 |
MEKK3 |
0.642 | -0.206 | 1 | 0.181 |
PKN1 |
0.642 | -0.056 | -3 | 0.723 |
CAMKK2 |
0.642 | -0.141 | -2 | 0.232 |
GAK |
0.641 | -0.092 | 1 | 0.239 |
MRCKA |
0.641 | -0.033 | -3 | 0.734 |
HPK1 |
0.641 | -0.077 | 1 | 0.185 |
KHS2 |
0.640 | -0.014 | 1 | 0.188 |
CAMKK1 |
0.640 | -0.203 | -2 | 0.217 |
MINK |
0.639 | -0.105 | 1 | 0.157 |
EEF2K |
0.638 | -0.033 | 3 | 0.794 |
CAMK1D |
0.638 | -0.062 | -3 | 0.677 |
NEK8 |
0.638 | -0.179 | 2 | 0.809 |
NEK4 |
0.637 | -0.151 | 1 | 0.158 |
STK33 |
0.635 | -0.106 | 2 | 0.681 |
DMPK1 |
0.635 | -0.014 | -3 | 0.759 |
VRK1 |
0.635 | -0.082 | 2 | 0.821 |
MST2 |
0.634 | -0.150 | 1 | 0.167 |
CHK2 |
0.634 | -0.041 | -3 | 0.660 |
DAPK1 |
0.634 | -0.079 | -3 | 0.774 |
CAMK1A |
0.633 | -0.047 | -3 | 0.669 |
CK2A2 |
0.633 | -0.086 | 1 | 0.147 |
NEK1 |
0.632 | -0.120 | 1 | 0.157 |
LIMK2_TYR |
0.632 | 0.180 | -3 | 0.824 |
PDHK3_TYR |
0.631 | 0.187 | 4 | 0.861 |
CRIK |
0.630 | -0.010 | -3 | 0.726 |
YSK1 |
0.630 | -0.103 | 2 | 0.780 |
ROCK1 |
0.630 | -0.041 | -3 | 0.735 |
ASK1 |
0.628 | -0.032 | 1 | 0.174 |
BIKE |
0.628 | -0.037 | 1 | 0.231 |
AAK1 |
0.627 | -0.004 | 1 | 0.237 |
MST1 |
0.627 | -0.154 | 1 | 0.156 |
CK1A |
0.626 | -0.042 | -3 | 0.396 |
TAK1 |
0.626 | -0.209 | 1 | 0.160 |
IRAK1 |
0.626 | -0.245 | -1 | 0.706 |
MEK2 |
0.625 | -0.176 | 2 | 0.809 |
OSR1 |
0.625 | -0.077 | 2 | 0.777 |
TESK1_TYR |
0.624 | 0.080 | 3 | 0.837 |
PKMYT1_TYR |
0.624 | 0.118 | 3 | 0.797 |
CK2A1 |
0.624 | -0.092 | 1 | 0.139 |
MYO3B |
0.623 | -0.064 | 2 | 0.802 |
MAP2K4_TYR |
0.621 | 0.044 | -1 | 0.820 |
TAO1 |
0.621 | -0.063 | 1 | 0.167 |
NEK3 |
0.621 | -0.158 | 1 | 0.178 |
PLK2 |
0.621 | -0.095 | -3 | 0.690 |
PDHK4_TYR |
0.620 | 0.053 | 2 | 0.851 |
MYO3A |
0.619 | -0.089 | 1 | 0.176 |
YANK3 |
0.618 | -0.031 | 2 | 0.461 |
MAP2K7_TYR |
0.618 | -0.015 | 2 | 0.856 |
RIPK2 |
0.617 | -0.222 | 1 | 0.144 |
PDHK1_TYR |
0.616 | 0.030 | -1 | 0.808 |
MAP2K6_TYR |
0.616 | 0.002 | -1 | 0.809 |
LIMK1_TYR |
0.613 | 0.028 | 2 | 0.854 |
TTK |
0.613 | -0.132 | -2 | 0.239 |
BMPR2_TYR |
0.612 | -0.055 | -1 | 0.792 |
JAK2 |
0.612 | -0.025 | 1 | 0.203 |
CSF1R |
0.612 | 0.030 | 3 | 0.748 |
PINK1_TYR |
0.611 | -0.139 | 1 | 0.235 |
RET |
0.611 | -0.045 | 1 | 0.197 |
NEK10_TYR |
0.610 | -0.028 | 1 | 0.171 |
TNK2 |
0.610 | 0.030 | 3 | 0.706 |
MST1R |
0.609 | -0.020 | 3 | 0.768 |
EPHB4 |
0.609 | 0.009 | -1 | 0.752 |
ABL2 |
0.609 | -0.002 | -1 | 0.730 |
ALPHAK3 |
0.608 | -0.066 | -1 | 0.692 |
TNK1 |
0.608 | 0.044 | 3 | 0.736 |
ROS1 |
0.607 | -0.030 | 3 | 0.723 |
TXK |
0.607 | 0.004 | 1 | 0.164 |
JAK1 |
0.606 | -0.012 | 1 | 0.173 |
TYK2 |
0.606 | -0.130 | 1 | 0.182 |
EPHA6 |
0.606 | -0.046 | -1 | 0.764 |
TNNI3K_TYR |
0.606 | -0.012 | 1 | 0.207 |
TYRO3 |
0.606 | -0.062 | 3 | 0.756 |
ABL1 |
0.605 | -0.020 | -1 | 0.729 |
YES1 |
0.602 | -0.047 | -1 | 0.797 |
STLK3 |
0.601 | -0.162 | 1 | 0.145 |
DDR1 |
0.600 | -0.072 | 4 | 0.795 |
JAK3 |
0.599 | -0.091 | 1 | 0.192 |
LCK |
0.599 | -0.042 | -1 | 0.762 |
FGFR1 |
0.598 | -0.030 | 3 | 0.696 |
FGR |
0.598 | -0.125 | 1 | 0.175 |
FGFR2 |
0.598 | -0.037 | 3 | 0.716 |
ITK |
0.597 | -0.058 | -1 | 0.735 |
MET |
0.596 | -0.040 | 3 | 0.743 |
KDR |
0.596 | -0.061 | 3 | 0.694 |
KIT |
0.595 | -0.075 | 3 | 0.741 |
BLK |
0.595 | -0.046 | -1 | 0.761 |
PDGFRB |
0.595 | -0.119 | 3 | 0.754 |
HCK |
0.594 | -0.099 | -1 | 0.762 |
DDR2 |
0.593 | 0.031 | 3 | 0.654 |
EPHA4 |
0.593 | -0.042 | 2 | 0.763 |
FER |
0.593 | -0.138 | 1 | 0.180 |
PDGFRA |
0.593 | -0.088 | 3 | 0.753 |
FLT3 |
0.591 | -0.129 | 3 | 0.754 |
MERTK |
0.591 | -0.072 | 3 | 0.718 |
SRMS |
0.591 | -0.103 | 1 | 0.156 |
TEK |
0.591 | -0.040 | 3 | 0.670 |
EPHB1 |
0.591 | -0.090 | 1 | 0.159 |
INSRR |
0.591 | -0.114 | 3 | 0.676 |
WEE1_TYR |
0.590 | -0.078 | -1 | 0.701 |
EPHB2 |
0.590 | -0.081 | -1 | 0.726 |
EPHB3 |
0.590 | -0.087 | -1 | 0.734 |
AXL |
0.590 | -0.099 | 3 | 0.716 |
FYN |
0.589 | -0.049 | -1 | 0.744 |
BMX |
0.589 | -0.059 | -1 | 0.663 |
YANK2 |
0.588 | -0.049 | 2 | 0.468 |
CK1G3 |
0.587 | -0.076 | -3 | 0.354 |
PTK2B |
0.586 | -0.045 | -1 | 0.726 |
FGFR3 |
0.585 | -0.068 | 3 | 0.683 |
FRK |
0.585 | -0.084 | -1 | 0.762 |
ALK |
0.585 | -0.092 | 3 | 0.652 |
BTK |
0.584 | -0.128 | -1 | 0.718 |
EPHA1 |
0.583 | -0.075 | 3 | 0.725 |
EPHA7 |
0.582 | -0.054 | 2 | 0.777 |
PTK6 |
0.582 | -0.132 | -1 | 0.678 |
LTK |
0.581 | -0.112 | 3 | 0.671 |
CSK |
0.581 | -0.040 | 2 | 0.786 |
TEC |
0.581 | -0.113 | -1 | 0.689 |
EGFR |
0.580 | -0.085 | 1 | 0.142 |
NTRK3 |
0.580 | -0.100 | -1 | 0.687 |
SRC |
0.580 | -0.083 | -1 | 0.747 |
INSR |
0.580 | -0.104 | 3 | 0.661 |
MATK |
0.580 | -0.079 | -1 | 0.654 |
FLT1 |
0.579 | -0.131 | -1 | 0.719 |
ERBB2 |
0.579 | -0.147 | 1 | 0.167 |
EPHA3 |
0.578 | -0.097 | 2 | 0.756 |
NTRK1 |
0.578 | -0.161 | -1 | 0.730 |
CK1G2 |
0.578 | -0.072 | -3 | 0.435 |
LYN |
0.577 | -0.112 | 3 | 0.649 |
FGFR4 |
0.576 | -0.080 | -1 | 0.679 |
NTRK2 |
0.576 | -0.164 | 3 | 0.685 |
ZAP70 |
0.575 | -0.037 | -1 | 0.603 |
FLT4 |
0.575 | -0.145 | 3 | 0.671 |
EPHA8 |
0.574 | -0.081 | -1 | 0.705 |
SYK |
0.573 | -0.090 | -1 | 0.663 |
MUSK |
0.573 | -0.110 | 1 | 0.132 |
PTK2 |
0.572 | -0.059 | -1 | 0.686 |
EPHA5 |
0.571 | -0.103 | 2 | 0.752 |
ERBB4 |
0.568 | -0.079 | 1 | 0.145 |
IGF1R |
0.562 | -0.125 | 3 | 0.587 |
EPHA2 |
0.561 | -0.097 | -1 | 0.666 |
FES |
0.552 | -0.111 | -1 | 0.644 |