Motif 267 (n=233)

Position-wise Probabilities

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uniprot genes site source protein function
A0A096LP49 CCDC187 S519 ochoa Coiled-coil domain-containing protein 187 None
A1X283 SH3PXD2B S291 ochoa SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
A4D1S0 KLRG2 S95 ochoa Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) None
C9JH25 PRRT4 S724 ochoa Proline-rich transmembrane protein 4 None
H3BRB1 None S238 ochoa polynucleotide adenylyltransferase (EC 2.7.7.19) None
O00267 SUPT5H S867 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O00268 TAF4 S109 ochoa Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}.
O14497 ARID1A S382 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14526 FCHO1 S523 ochoa F-BAR domain only protein 1 Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}.
O14686 KMT2D S477 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S609 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S618 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S654 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S2342 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14813 PHOX2A S202 psp Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
O14994 SYN3 S470 ochoa|psp Synapsin-3 (Synapsin III) May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15054 KDM6B S799 ochoa Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}.
O15164 TRIM24 S110 ochoa Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.
O15417 TNRC18 S1038 ochoa Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) None
O15417 TNRC18 S1957 ochoa Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) None
O15446 POLR1G S136 ochoa DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}.
O15503 INSIG1 S74 psp Insulin-induced gene 1 protein (INSIG-1) Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}.
O43561 LAT S84 ochoa Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
O43593 HR S316 ochoa Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}.
O43734 TRAF3IP2 S383 ochoa E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}.
O60673 REV3L S2183 ochoa DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}.
O75030 MITF S180 psp Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}.
O75369 FLNB S440 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S730 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S833 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S932 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1028 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1121 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1316 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1409 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1505 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S1602 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75369 FLNB S2274 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75398 DEAF1 S176 ochoa Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:0000269|PubMed:11705868, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.
O75420 GIGYF1 S756 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75808 CAPN15 S233 ochoa Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) None
O75864 PPP1R37 S597 ochoa Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.
O95171 SCEL S196 ochoa Sciellin May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
O95644 NFATC1 S403 psp Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
O95785 WIZ S1146 ochoa Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}.
O96013 PAK4 S291 ochoa|psp Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}.
P06400 RB1 S788 ochoa|psp Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.
P07101 TH S62 psp Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.
P08235 NR3C2 S703 ochoa Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.
P0C1Z6 TFPT S180 ochoa|psp TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
P15336 ATF2 S266 ochoa Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.
P21333 FLNA S468 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S757 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S860 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S959 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1055 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1343 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1436 ochoa|psp Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1533 ochoa|psp Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1630 ochoa|psp Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1734 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1946 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21917 DRD4 S245 psp D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}.
P30414 NKTR S613 ochoa NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}.
P33076 CIITA S288 psp MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}.
P35568 IRS1 S892 ochoa|psp Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P42694 HELZ S1442 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P43354 NR4A2 S359 ochoa Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}.
P48378 RFX2 S28 ochoa DNA-binding protein RFX2 (Regulatory factor X 2) Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:10330134}.
P48382 RFX5 S347 ochoa DNA-binding protein RFX5 (Regulatory factor X 5) Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
P48634 PRRC2A S1147 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48634 PRRC2A S1219 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48681 NES S398 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49418 AMPH S293 psp Amphiphysin May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
P50548 ERF S246 psp ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.
P50548 ERF S251 psp ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.
P51531 SMARCA2 S175 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51617 IRAK1 S173 psp Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}.
P52746 ZNF142 S1319 ochoa Zinc finger protein 142 May be involved in transcriptional regulation. {ECO:0000305}.
P54259 ATN1 S739 ochoa|psp Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P55196 AFDN S1455 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P56945 BCAR1 S355 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P78559 MAP1A S2238 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P98177 FOXO4 S230 ochoa|psp Forkhead box protein O4 (Fork head domain transcription factor AFX1) Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.
Q02086 SP2 S78 ochoa Transcription factor Sp2 Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Q03164 KMT2A S3036 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q06190 PPP2R3A S692 ochoa Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q08174 PCDH1 S962 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q12948 FOXC1 S241 ochoa|psp Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.
Q13094 LCP2 S410 ochoa|psp Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}.
Q13118 KLF10 S249 ochoa Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.
Q13322 GRB10 S150 ochoa|psp Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.
Q13625 TP53BP2 Y874 psp Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q14244 MAP7 S365 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14315 FLNC S462 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S559 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S954 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1050 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1527 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1624 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1728 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1848 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1940 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S2395 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14526 HIC1 S270 ochoa Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}.
Q14676 MDC1 S1348 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14676 MDC1 S1471 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14676 MDC1 S1553 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14699 RFTN1 S239 ochoa Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Q14934 NFATC4 S264 ochoa Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}.
Q15654 TRIP6 S147 ochoa Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}.
Q15797 SMAD1 S214 psp Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.
Q16633 POU2AF1 S184 psp POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1) Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). {ECO:0000250|UniProtKB:Q64693, ECO:0000269|PubMed:7623806, ECO:0000269|PubMed:7779176, ECO:0000269|PubMed:7859290}.
Q2NL68 PROSER3 S356 ochoa Proline and serine-rich protein 3 None
Q2TAL5 SMTNL2 S101 ochoa Smoothelin-like protein 2 None
Q3KP66 INAVA S313 ochoa Innate immunity activator protein Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}.
Q49AN0 CRY2 S558 ochoa Cryptochrome-2 Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). {ECO:0000250|UniProtKB:Q9R194, ECO:0000269|PubMed:10531061, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:16790549}.
Q504T8 MIDN S212 ochoa Midnolin (Midbrain nucleolar protein) Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7, ECO:0000269|PubMed:37616343}.
Q5QP82 DCAF10 S92 ochoa DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.
Q5UE93 PIK3R6 S358 ochoa|psp Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP) Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.
Q5VT52 RPRD2 S965 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5VTT5 MYOM3 S857 ochoa Myomesin-3 (Myomesin family member 3) May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}.
Q5VUA4 ZNF318 S698 ochoa Zinc finger protein 318 (Endocrine regulatory protein) [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.
Q63HR2 TNS2 S975 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q63ZY3 KANK2 S19 ochoa KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}.
Q68CP9 ARID2 S689 ochoa AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q68EM7 ARHGAP17 S762 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6B0I6 KDM4D S505 ochoa Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:35145029}.
Q6NYC8 PPP1R18 S432 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6PCB5 RSBN1L S79 ochoa Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}.
Q6XZF7 DNMBP S622 ochoa Dynamin-binding protein (Scaffold protein Tuba) Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}.
Q6ZRI6 C15orf39 S116 ochoa Uncharacterized protein C15orf39 None
Q70E73 RAPH1 S856 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q70E73 RAPH1 S894 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q7L3V2 RTL10 S289 ochoa Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}.
Q7Z3B3 KANSL1 S971 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z6G3 NECAB2 S57 ochoa N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2) May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.
Q86T03 PIP4P1 S162 ochoa Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B) Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). {ECO:0000269|PubMed:16365287, ECO:0000269|PubMed:25035345, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:29644770}.
Q86TI0 TBC1D1 S585 ochoa TBC1 domain family member 1 May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86UU1 PHLDB1 S223 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86VM9 ZC3H18 S487 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q86Y01 DTX1 S279 ochoa E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.
Q86YN6 PPARGC1B S263 ochoa Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}.
Q8IU68 TMC8 S683 ochoa Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}.
Q8IUW3 SPATA2L S252 ochoa Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) None
Q8IUW5 RELL1 S166 ochoa RELT-like protein 1 Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.
Q8IX07 ZFPM1 S61 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IX07 ZFPM1 S84 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IZL8 PELP1 S991 psp Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.
Q8IZP0 ABI1 S183 ochoa|psp Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q8N1G0 ZNF687 S183 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N3F8 MICALL1 S323 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N8E2 ZNF513 S253 ochoa Zinc finger protein 513 Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}.
Q8N8Q3 ENDOV S261 ochoa Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease) [Isoform 1]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:25195743, PubMed:27573237, PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:25195743, PubMed:31703097). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746). {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:23912683, ECO:0000269|PubMed:23912718, ECO:0000269|PubMed:25195743, ECO:0000269|PubMed:27573237, ECO:0000269|PubMed:31703097, ECO:0000305}.; FUNCTION: [Isoform 6]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}.; FUNCTION: [Isoform 7]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097). {ECO:0000269|PubMed:31703097}.
Q8TAP9 MPLKIP S40 ochoa M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
Q8TDC3 BRSK1 S508 ochoa Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.
Q8TE04 PANK1 S215 ochoa Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:14523052, ECO:0000269|PubMed:17631502}.
Q8TEK3 DOT1L S834 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8TF74 WIPF2 S303 ochoa WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.
Q8WUZ0 BCL7C S126 ochoa B-cell CLL/lymphoma 7 protein family member C May play an anti-apoptotic role. {ECO:0000250}.
Q8WV28 BLNK S219 ochoa B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.
Q8WXD9 CASKIN1 S719 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXD9 CASKIN1 S787 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXD9 CASKIN1 S819 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXD9 CASKIN1 S1257 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q92570 NR4A3 S393 ochoa Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}.
Q92615 LARP4B S524 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q96AD5 PNPLA2 S476 ochoa Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}.
Q96AP7 ESAM S359 ochoa Endothelial cell-selective adhesion molecule Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}.
Q96EZ8 MCRS1 S108 ochoa Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}.
Q96F45 ZNF503 S102 ochoa Zinc finger protein 503 May function as a transcriptional repressor. {ECO:0000250}.
Q96HA1 POM121 S179 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96JM3 CHAMP1 S214 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96KM6 ZNF512B S63 ochoa Zinc finger protein 512B Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}.
Q96KQ7 EHMT2 S569 ochoa|psp Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}.
Q96LB3 IFT74 S32 ochoa Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:33689014}.
Q96QC0 PPP1R10 S337 ochoa Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}.
Q99501 GAS2L1 S306 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99626 CDX2 S283 ochoa|psp Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}.
Q99814 EPAS1 S790 psp Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}.
Q9BRQ0 PYGO2 S279 ochoa Pygopus homolog 2 Involved in signal transduction through the Wnt pathway.
Q9BT49 THAP7 S210 ochoa THAP domain-containing protein 7 Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000269|PubMed:15561719}.
Q9BVW5 TIPIN S31 ochoa TIMELESS-interacting protein Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}.
Q9BWG6 SCNM1 S183 ochoa Sodium channel modifier 1 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}.
Q9BX40 LSM14B S115 ochoa Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}.
Q9BZL4 PPP1R12C S407 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9C000 NLRP1 S107 psp NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:27662089, PubMed:31484767, PubMed:33093214, PubMed:33410748, PubMed:33731929, PubMed:33731932, PubMed:35857590). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:12191486, PubMed:17349957, PubMed:22665479). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by some human enteroviruses and rhinoviruses, double-stranded RNA, UV-B irradiation, or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:25562666, PubMed:30096351, PubMed:30291141, PubMed:33093214, PubMed:33243852, PubMed:33410748, PubMed:35857590). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:12191486, PubMed:17349957, PubMed:22665479, PubMed:32051255, PubMed:33093214). In the absence of GSDMD expression, the NLRP1 inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) (PubMed:33852854, PubMed:35594856). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses, such as Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). The NLRP1 inflammasome is also activated in response to UV-B irradiation causing ribosome collisions: ribosome collisions cause phosphorylation and activation of NLRP1 in a MAP3K20-dependent manner, leading to pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:11113115, ECO:0000269|PubMed:12191486, ECO:0000269|PubMed:15212762, ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:22665479, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:25562666, ECO:0000269|PubMed:27662089, ECO:0000269|PubMed:30096351, ECO:0000269|PubMed:30291141, ECO:0000269|PubMed:31484767, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33243852, ECO:0000269|PubMed:33410748, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932, ECO:0000269|PubMed:33852854, ECO:0000269|PubMed:35594856, ECO:0000269|PubMed:35857590}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1]: Constitutes the precursor of the NLRP1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals. {ECO:0000269|PubMed:22087307}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, N-terminus]: Regulatory part that prevents formation of the NLRP1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the NLRP1 inflammasome (PubMed:33093214). {ECO:0000269|PubMed:33093214}.; FUNCTION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Constitutes the active part of the NLRP1 inflammasome (PubMed:33093214, PubMed:33731929, PubMed:33731932). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the NLRP1 inflammasome (PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing this form, which polymerizes and associates with PYCARD/ASC to form of the NLRP1 inflammasome complex: the NLRP1 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:33093214). {ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33731929, ECO:0000269|PubMed:33731932}.; FUNCTION: [Isoform 2]: It is unclear whether is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). {ECO:0000269|PubMed:17349957, ECO:0000269|PubMed:22665479}.
Q9C0C2 TNKS1BP1 S369 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0D6 FHDC1 S525 ochoa FH2 domain-containing protein 1 (Inverted formin-1) Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}.
Q9C0E8 LNPK S194 ochoa Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}.
Q9C0H5 ARHGAP39 S366 ochoa Rho GTPase-activating protein 39 None
Q9C0K0 BCL11B S318 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9C0K0 BCL11B S401 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H0F6 SHARPIN S165 ochoa|psp Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9H2J1 ARRDC1-AS1 S71 ochoa Uncharacterized protein ARRDC1-AS1 (ARRDC1 antisense RNA 1) (ARRDC1 antisense gene protein 1) None
Q9H2Z4 NKX2-4 S271 ochoa Homeobox protein Nkx-2.4 (Homeobox protein NK-2 homolog D) Probable transcription factor.
Q9H3P2 NELFA S363 ochoa Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
Q9H3T3 SEMA6B S822 ochoa Semaphorin-6B (Semaphorin-Z) (Sema Z) Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}.
Q9H6E5 TUT1 S238 ochoa Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}.
Q9H6F5 CCDC86 S160 ochoa Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}.
Q9H7N4 SCAF1 S548 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9 PLEKHG2 S450 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9H7S9 ZNF703 S78 ochoa Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.
Q9H8N7 ZNF395 S386 ochoa Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) Plays a role in papillomavirus genes transcription.
Q9HBB8 CDHR5 S754 ochoa Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}.
Q9HC56 PCDH9 S932 ochoa Protocadherin-9 Potential calcium-dependent cell-adhesion protein.
Q9NPC6 MYOZ2 S116 ochoa Myozenin-2 (Calsarcin-1) (FATZ-related protein 2) Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Q9NPF5 DMAP1 S418 ochoa DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}.
Q9NQC3 RTN4 S152 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NRA0 SPHK2 S414 ochoa Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Q9NRY4 ARHGAP35 S1451 ochoa Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.
Q9NWQ4 GPATCH2L S447 ochoa G patch domain-containing protein 2-like None
Q9NYQ7 CELSR3 S3175 ochoa Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9P206 NHSL3 S612 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P206 NHSL3 S979 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P275 USP36 S546 ochoa Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}.
Q9UGJ0 PRKAG2 S87 ochoa 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}.
Q9UGK3 STAP2 S289 ochoa Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate) Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}.
Q9UHB6 LIMA1 S362 ochoa|psp LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UJF2 RASAL2 S780 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UJM3 ERRFI1 S136 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UK80 USP21 S93 ochoa|psp Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}.
Q9UKA4 AKAP11 S422 ochoa A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UL51 HCN2 S779 ochoa Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}.
Q9ULD5 ZNF777 S623 ochoa Zinc finger protein 777 May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.
Q9ULE3 DENND2A S310 ochoa DENN domain-containing protein 2A Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}.
Q9ULM3 YEATS2 S447 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9Y3L3 SH3BP1 S598 ochoa SH3 domain-binding protein 1 GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
Q9Y3X0 CCDC9 S386 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y4H2 IRS2 S915 ochoa|psp Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y4R8 TELO2 S637 ochoa Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.
Q9Y613 FHOD1 S498 ochoa|psp FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.
P46695 IER3 S126 GPS6|EPSD Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1) May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:22565310}.
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reactome_id name p -log10_p
R-HSA-4839726 Chromatin organization 8.463506e-07 6.072
R-HSA-3247509 Chromatin modifying enzymes 9.751826e-06 5.011
R-HSA-9932444 ATP-dependent chromatin remodelers 6.756238e-05 4.170
R-HSA-9932451 SWI/SNF chromatin remodelers 6.756238e-05 4.170
R-HSA-74713 IRS activation 1.235207e-04 3.908
R-HSA-74160 Gene expression (Transcription) 1.231189e-04 3.910
R-HSA-383280 Nuclear Receptor transcription pathway 1.749408e-04 3.757
R-HSA-212165 Epigenetic regulation of gene expression 2.336127e-04 3.632
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 2.741463e-04 3.562
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 3.807285e-04 3.419
R-HSA-212436 Generic Transcription Pathway 4.629685e-04 3.334
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 5.585566e-04 3.253
R-HSA-74749 Signal attenuation 7.461479e-04 3.127
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.121758e-03 2.950
R-HSA-73857 RNA Polymerase II Transcription 1.178640e-03 2.929
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.886587e-03 2.724
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.886587e-03 2.724
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 2.197360e-03 2.658
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 2.909836e-03 2.536
R-HSA-8848021 Signaling by PTK6 2.779392e-03 2.556
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 2.779392e-03 2.556
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 3.704515e-03 2.431
R-HSA-3214841 PKMTs methylate histone lysines 4.084556e-03 2.389
R-HSA-5357786 TNFR1-induced proapoptotic signaling 5.261430e-03 2.279
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 5.768980e-03 2.239
R-HSA-3700989 Transcriptional Regulation by TP53 5.913817e-03 2.228
R-HSA-8849473 PTK6 Expression 8.054416e-03 2.094
R-HSA-112412 SOS-mediated signalling 8.054416e-03 2.094
R-HSA-73887 Death Receptor Signaling 8.674844e-03 2.062
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 9.257480e-03 2.034
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 1.005551e-02 1.998
R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus 1.320194e-02 1.879
R-HSA-198203 PI3K/AKT activation 1.326250e-02 1.877
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.326250e-02 1.877
R-HSA-2586552 Signaling by Leptin 1.326250e-02 1.877
R-HSA-3214847 HATs acetylate histones 1.645423e-02 1.784
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 1.566871e-02 1.805
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1.735447e-02 1.761
R-HSA-8878171 Transcriptional regulation by RUNX1 1.797650e-02 1.745
R-HSA-167172 Transcription of the HIV genome 1.931336e-02 1.714
R-HSA-209543 p75NTR recruits signalling complexes 1.957583e-02 1.708
R-HSA-114604 GPVI-mediated activation cascade 2.021248e-02 1.694
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 2.190955e-02 1.659
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 2.144980e-02 1.669
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 2.272775e-02 1.643
R-HSA-674695 RNA Polymerase II Pre-transcription Events 2.463721e-02 1.608
R-HSA-193639 p75NTR signals via NF-kB 2.690086e-02 1.570
R-HSA-1257604 PIP3 activates AKT signaling 2.611012e-02 1.583
R-HSA-446353 Cell-extracellular matrix interactions 2.690086e-02 1.570
R-HSA-3214858 RMTs methylate histone arginines 3.280853e-02 1.484
R-HSA-5633007 Regulation of TP53 Activity 3.278955e-02 1.484
R-HSA-5357905 Regulation of TNFR1 signaling 3.605083e-02 1.443
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 4.022010e-02 1.396
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 4.022010e-02 1.396
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 4.022010e-02 1.396
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 3.722952e-02 1.429
R-HSA-9854907 Regulation of MITF-M dependent genes involved in metabolism 6.429738e-02 1.192
R-HSA-844455 The NLRP1 inflammasome 6.429738e-02 1.192
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 6.429738e-02 1.192
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 6.429738e-02 1.192
R-HSA-1296061 HCN channels 7.665428e-02 1.115
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 7.665428e-02 1.115
R-HSA-9854909 Regulation of MITF-M dependent genes involved in invasion 8.884875e-02 1.051
R-HSA-111463 SMAC (DIABLO) binds to IAPs 8.884875e-02 1.051
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 8.884875e-02 1.051
R-HSA-111469 SMAC, XIAP-regulated apoptotic response 1.008829e-01 0.996
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 1.008829e-01 0.996
R-HSA-9027283 Erythropoietin activates STAT5 1.127589e-01 0.948
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 1.360444e-01 0.866
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 4.112091e-02 1.386
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.587216e-01 0.799
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.808062e-01 0.743
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1.916312e-01 0.718
R-HSA-937039 IRAK1 recruits IKK complex 1.916312e-01 0.718
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1.916312e-01 0.718
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 7.201438e-02 1.143
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 7.201438e-02 1.143
R-HSA-167287 HIV elongation arrest and recovery 7.580120e-02 1.120
R-HSA-167290 Pausing and recovery of HIV elongation 7.580120e-02 1.120
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 2.023138e-01 0.694
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 2.023138e-01 0.694
R-HSA-9027284 Erythropoietin activates RAS 2.232592e-01 0.651
R-HSA-5656121 Translesion synthesis by POLI 2.335258e-01 0.632
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 2.335258e-01 0.632
R-HSA-5655862 Translesion synthesis by POLK 2.436572e-01 0.613
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.536553e-01 0.596
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 6.308042e-02 1.200
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 2.635219e-01 0.579
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1.298837e-01 0.886
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 1.298837e-01 0.886
R-HSA-167161 HIV Transcription Initiation 1.388450e-01 0.857
R-HSA-75953 RNA Polymerase II Transcription Initiation 1.388450e-01 0.857
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 3.109411e-01 0.507
R-HSA-112382 Formation of RNA Pol II elongation complex 1.901252e-01 0.721
R-HSA-9619483 Activation of AMPK downstream of NMDARs 3.638488e-01 0.439
R-HSA-9006335 Signaling by Erythropoietin 3.722649e-01 0.429
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 3.805701e-01 0.420
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 3.805701e-01 0.420
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 3.887660e-01 0.410
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 3.887660e-01 0.410
R-HSA-1855170 IPs transport between nucleus and cytosol 4.048353e-01 0.393
R-HSA-159227 Transport of the SLBP independent Mature mRNA 4.048353e-01 0.393
R-HSA-9856651 MITF-M-dependent gene expression 1.862962e-01 0.730
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 3.017068e-01 0.520
R-HSA-202433 Generation of second messenger molecules 1.298837e-01 0.886
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 1.298837e-01 0.886
R-HSA-75955 RNA Polymerase II Transcription Elongation 1.949133e-01 0.710
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 2.923495e-01 0.534
R-HSA-9730414 MITF-M-regulated melanocyte development 9.246091e-02 1.034
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.571450e-01 0.804
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 1.254561e-01 0.902
R-HSA-167169 HIV Transcription Elongation 1.298837e-01 0.886
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 1.474580e-01 0.831
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1.916312e-01 0.718
R-HSA-73863 RNA Polymerase I Transcription Termination 3.553204e-01 0.449
R-HSA-73776 RNA Polymerase II Promoter Escape 1.479364e-01 0.830
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.805701e-01 0.420
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 2.826230e-01 0.549
R-HSA-2424491 DAP12 signaling 8.355835e-02 1.078
R-HSA-8847453 Synthesis of PIPs in the nucleus 1.244787e-01 0.905
R-HSA-2025928 Calcineurin activates NFAT 1.474580e-01 0.831
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1.808062e-01 0.743
R-HSA-113418 Formation of the Early Elongation Complex 7.580120e-02 1.120
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 1.388450e-01 0.857
R-HSA-73762 RNA Polymerase I Transcription Initiation 1.433753e-01 0.844
R-HSA-73864 RNA Polymerase I Transcription 3.167806e-01 0.499
R-HSA-72086 mRNA Capping 3.722649e-01 0.429
R-HSA-2871809 FCERI mediated Ca+2 mobilization 2.462604e-01 0.609
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 8.924705e-02 1.049
R-HSA-9614399 Regulation of localization of FOXO transcription factors 1.698370e-01 0.770
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 7.580120e-02 1.120
R-HSA-110312 Translesion synthesis by REV1 2.232592e-01 0.651
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 2.436572e-01 0.613
R-HSA-9675126 Diseases of mitotic cell cycle 3.968539e-01 0.401
R-HSA-73854 RNA Polymerase I Promoter Clearance 3.070501e-01 0.513
R-HSA-2428928 IRS-related events triggered by IGF1R 2.336674e-01 0.631
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 1.298837e-01 0.886
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 1.298837e-01 0.886
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 3.017068e-01 0.520
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 3.601113e-01 0.444
R-HSA-9614657 FOXO-mediated transcription of cell death genes 2.635219e-01 0.579
R-HSA-201451 Signaling by BMP 3.553204e-01 0.449
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 8.884875e-02 1.051
R-HSA-193634 Axonal growth inhibition (RHOA activation) 1.360444e-01 0.866
R-HSA-9927354 Co-stimulation by ICOS 1.360444e-01 0.866
R-HSA-428543 Inactivation of CDC42 and RAC1 1.474580e-01 0.831
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.587216e-01 0.799
R-HSA-209560 NF-kB is activated and signals survival 1.808062e-01 0.743
R-HSA-1482883 Acyl chain remodeling of DAG and TAG 2.023138e-01 0.694
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2.023138e-01 0.694
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.635219e-01 0.579
R-HSA-113510 E2F mediated regulation of DNA replication 2.732587e-01 0.563
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 3.200537e-01 0.495
R-HSA-162599 Late Phase of HIV Life Cycle 6.381702e-02 1.195
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 1.617120e-01 0.791
R-HSA-74751 Insulin receptor signalling cascade 7.212468e-02 1.142
R-HSA-111471 Apoptotic factor-mediated response 2.635219e-01 0.579
R-HSA-8849474 PTK6 Activates STAT3 8.884875e-02 1.051
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.916312e-01 0.718
R-HSA-112399 IRS-mediated signalling 2.142060e-01 0.669
R-HSA-75893 TNF signaling 5.460569e-02 1.263
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2.635219e-01 0.579
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 3.466782e-01 0.460
R-HSA-2428924 IGF1R signaling cascade 2.483324e-01 0.605
R-HSA-9909396 Circadian clock 1.360935e-01 0.866
R-HSA-139915 Activation of PUMA and translocation to mitochondria 1.244787e-01 0.905
R-HSA-9603381 Activated NTRK3 signals through PI3K 1.244787e-01 0.905
R-HSA-450341 Activation of the AP-1 family of transcription factors 1.474580e-01 0.831
R-HSA-9761174 Formation of intermediate mesoderm 1.587216e-01 0.799
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.109411e-01 0.507
R-HSA-193697 p75NTR regulates axonogenesis 1.474580e-01 0.831
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2.532285e-01 0.596
R-HSA-2172127 DAP12 interactions 1.525268e-01 0.817
R-HSA-74752 Signaling by Insulin receptor 1.553725e-01 0.809
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 1.808062e-01 0.743
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2.128558e-01 0.672
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 2.923495e-01 0.534
R-HSA-162587 HIV Life Cycle 8.568632e-02 1.067
R-HSA-9842663 Signaling by LTK 1.916312e-01 0.718
R-HSA-199418 Negative regulation of the PI3K/AKT network 4.552069e-02 1.342
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 3.466782e-01 0.460
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 2.128558e-01 0.672
R-HSA-193704 p75 NTR receptor-mediated signalling 6.030773e-02 1.220
R-HSA-2559585 Oncogene Induced Senescence 1.081400e-01 0.966
R-HSA-162906 HIV Infection 2.332102e-01 0.632
R-HSA-390651 Dopamine receptors 7.665428e-02 1.115
R-HSA-8948747 Regulation of PTEN localization 1.244787e-01 0.905
R-HSA-198693 AKT phosphorylates targets in the nucleus 1.474580e-01 0.831
R-HSA-111461 Cytochrome c-mediated apoptotic response 1.808062e-01 0.743
R-HSA-428540 Activation of RAC1 1.808062e-01 0.743
R-HSA-6811555 PI5P Regulates TP53 Acetylation 2.023138e-01 0.694
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 2.335258e-01 0.632
R-HSA-9945266 Differentiation of T cells 2.335258e-01 0.632
R-HSA-8941326 RUNX2 regulates bone development 1.124062e-01 0.949
R-HSA-429947 Deadenylation of mRNA 3.290464e-01 0.483
R-HSA-1482801 Acyl chain remodelling of PS 3.379207e-01 0.471
R-HSA-1839124 FGFR1 mutant receptor activation 4.048353e-01 0.393
R-HSA-109606 Intrinsic Pathway for Apoptosis 2.093642e-01 0.679
R-HSA-3214842 HDMs demethylate histones 6.463589e-02 1.190
R-HSA-5693607 Processing of DNA double-strand break ends 3.313162e-01 0.480
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.190584e-01 0.659
R-HSA-389357 CD28 dependent PI3K/Akt signaling 3.553204e-01 0.449
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 2.581270e-01 0.588
R-HSA-1592230 Mitochondrial biogenesis 2.533317e-01 0.596
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 3.313162e-01 0.480
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3.638488e-01 0.439
R-HSA-9613354 Lipophagy 1.474580e-01 0.831
R-HSA-427601 Inorganic anion exchange by SLC26 transporters 1.698370e-01 0.770
R-HSA-5696394 DNA Damage Recognition in GG-NER 9.974463e-02 1.001
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 3.017068e-01 0.520
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 3.200537e-01 0.495
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 3.200537e-01 0.495
R-HSA-8943724 Regulation of PTEN gene transcription 2.287901e-01 0.641
R-HSA-9930044 Nuclear RNA decay 4.048353e-01 0.393
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.924075e-01 0.534
R-HSA-2559583 Cellular Senescence 1.277344e-01 0.894
R-HSA-9842860 Regulation of endogenous retroelements 6.519287e-02 1.186
R-HSA-9627069 Regulation of the apoptosome activity 1.587216e-01 0.799
R-HSA-9675151 Disorders of Developmental Biology 2.436572e-01 0.613
R-HSA-209905 Catecholamine biosynthesis 2.536553e-01 0.596
R-HSA-109704 PI3K Cascade 1.805998e-01 0.743
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 3.553204e-01 0.449
R-HSA-400685 Sema4D in semaphorin signaling 3.379207e-01 0.471
R-HSA-5689880 Ub-specific processing proteases 2.529180e-01 0.597
R-HSA-9733709 Cardiogenesis 9.561942e-02 1.019
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 1.244787e-01 0.905
R-HSA-196783 Coenzyme A biosynthesis 2.436572e-01 0.613
R-HSA-912631 Regulation of signaling by CBL 2.732587e-01 0.563
R-HSA-622312 Inflammasomes 3.638488e-01 0.439
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 4.048353e-01 0.393
R-HSA-9707564 Cytoprotection by HMOX1 3.409593e-01 0.467
R-HSA-397795 G-protein beta:gamma signalling 4.048353e-01 0.393
R-HSA-450294 MAP kinase activation 2.336674e-01 0.631
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 3.722649e-01 0.429
R-HSA-354192 Integrin signaling 4.048353e-01 0.393
R-HSA-1169408 ISG15 antiviral mechanism 3.021748e-01 0.520
R-HSA-8878166 Transcriptional regulation by RUNX2 2.604323e-01 0.584
R-HSA-448424 Interleukin-17 signaling 2.777261e-01 0.556
R-HSA-430116 GP1b-IX-V activation signalling 1.474580e-01 0.831
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 2.483324e-01 0.605
R-HSA-9034015 Signaling by NTRK3 (TRKC) 3.017068e-01 0.520
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 3.109411e-01 0.507
R-HSA-114452 Activation of BH3-only proteins 3.805701e-01 0.420
R-HSA-111458 Formation of apoptosome 1.587216e-01 0.799
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 2.023138e-01 0.694
R-HSA-200425 Carnitine shuttle 3.200537e-01 0.495
R-HSA-2219528 PI3K/AKT Signaling in Cancer 1.006641e-01 0.997
R-HSA-76002 Platelet activation, signaling and aggregation 3.528462e-01 0.452
R-HSA-5689603 UCH proteinases 3.070501e-01 0.513
R-HSA-5688426 Deubiquitination 1.618397e-01 0.791
R-HSA-6807070 PTEN Regulation 3.432100e-01 0.464
R-HSA-8853659 RET signaling 1.124062e-01 0.949
R-HSA-6804760 Regulation of TP53 Activity through Methylation 2.635219e-01 0.579
R-HSA-9006925 Intracellular signaling by second messengers 5.434559e-02 1.265
R-HSA-9664873 Pexophagy 1.587216e-01 0.799
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.338465e-01 0.873
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.109411e-01 0.507
R-HSA-9830674 Formation of the ureteric bud 3.200537e-01 0.495
R-HSA-9764560 Regulation of CDH1 Gene Transcription 2.777261e-01 0.556
R-HSA-8983711 OAS antiviral response 1.916312e-01 0.718
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.114561e-01 0.675
R-HSA-186763 Downstream signal transduction 3.887660e-01 0.410
R-HSA-187037 Signaling by NTRK1 (TRKA) 2.962632e-01 0.528
R-HSA-9700206 Signaling by ALK in cancer 2.114561e-01 0.675
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 3.200537e-01 0.495
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 5.753370e-02 1.240
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 3.457649e-01 0.461
R-HSA-166520 Signaling by NTRKs 3.791923e-01 0.421
R-HSA-9682706 Replication of the SARS-CoV-1 genome 2.023138e-01 0.694
R-HSA-5675482 Regulation of necroptotic cell death 4.048353e-01 0.393
R-HSA-9694686 Replication of the SARS-CoV-2 genome 2.536553e-01 0.596
R-HSA-446728 Cell junction organization 3.633203e-01 0.440
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.005946e-01 0.397
R-HSA-9671555 Signaling by PDGFR in disease 3.017068e-01 0.520
R-HSA-1266695 Interleukin-7 signaling 6.463589e-02 1.190
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 2.128558e-01 0.672
R-HSA-982772 Growth hormone receptor signaling 5.753370e-02 1.240
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 2.732587e-01 0.563
R-HSA-9663891 Selective autophagy 3.696117e-01 0.432
R-HSA-8986944 Transcriptional Regulation by MECP2 3.837569e-01 0.416
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 4.127116e-01 0.384
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 4.127116e-01 0.384
R-HSA-1482788 Acyl chain remodelling of PC 4.127116e-01 0.384
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 4.127116e-01 0.384
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 4.199274e-01 0.377
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 4.204841e-01 0.376
R-HSA-180746 Nuclear import of Rev protein 4.204841e-01 0.376
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 4.204841e-01 0.376
R-HSA-168638 NOD1/2 Signaling Pathway 4.204841e-01 0.376
R-HSA-975871 MyD88 cascade initiated on plasma membrane 4.253276e-01 0.371
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 4.253276e-01 0.371
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 4.253276e-01 0.371
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 4.281543e-01 0.368
R-HSA-1482839 Acyl chain remodelling of PE 4.281543e-01 0.368
R-HSA-180910 Vpr-mediated nuclear import of PICs 4.431927e-01 0.353
R-HSA-2559580 Oxidative Stress Induced Senescence 4.433368e-01 0.353
R-HSA-1483255 PI Metabolism 4.433368e-01 0.353
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4.505637e-01 0.346
R-HSA-5213460 RIPK1-mediated regulated necrosis 4.505637e-01 0.346
R-HSA-9958790 SLC-mediated transport of inorganic anions 4.505637e-01 0.346
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.522244e-01 0.345
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.578375e-01 0.339
R-HSA-168276 NS1 Mediated Effects on Host Pathways 4.578375e-01 0.339
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 4.578375e-01 0.339
R-HSA-8953750 Transcriptional Regulation by E2F6 4.578375e-01 0.339
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 4.578375e-01 0.339
R-HSA-201556 Signaling by ALK 4.578375e-01 0.339
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 4.610313e-01 0.336
R-HSA-5696398 Nucleotide Excision Repair 4.610313e-01 0.336
R-HSA-1500931 Cell-Cell communication 4.622218e-01 0.335
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 4.650154e-01 0.333
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 4.650154e-01 0.333
R-HSA-177243 Interactions of Rev with host cellular proteins 4.650154e-01 0.333
R-HSA-176033 Interactions of Vpr with host cellular proteins 4.650154e-01 0.333
R-HSA-9909648 Regulation of PD-L1(CD274) expression 4.667862e-01 0.331
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 4.720988e-01 0.326
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 4.720988e-01 0.326
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 4.720988e-01 0.326
R-HSA-9607240 FLT3 Signaling 4.720988e-01 0.326
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 4.720988e-01 0.326
R-HSA-8853884 Transcriptional Regulation by VENTX 4.720988e-01 0.326
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 4.740861e-01 0.324
R-HSA-975155 MyD88 dependent cascade initiated on endosome 4.783954e-01 0.320
R-HSA-9932298 Degradation of CRY and PER proteins 4.790888e-01 0.320
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 4.790888e-01 0.320
R-HSA-5655302 Signaling by FGFR1 in disease 4.790888e-01 0.320
R-HSA-202403 TCR signaling 4.826832e-01 0.316
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 4.826832e-01 0.316
R-HSA-166166 MyD88-independent TLR4 cascade 4.826832e-01 0.316
R-HSA-165159 MTOR signalling 4.859867e-01 0.313
R-HSA-400508 Incretin synthesis, secretion, and inactivation 4.859867e-01 0.313
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 4.859867e-01 0.313
R-HSA-2871796 FCERI mediated MAPK activation 4.911936e-01 0.309
R-HSA-1433557 Signaling by SCF-KIT 4.927937e-01 0.307
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4.954158e-01 0.305
R-HSA-69231 Cyclin D associated events in G1 4.995109e-01 0.301
R-HSA-69236 G1 Phase 4.995109e-01 0.301
R-HSA-375280 Amine ligand-binding receptors 4.995109e-01 0.301
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 4.996158e-01 0.301
R-HSA-388841 Regulation of T cell activation by CD28 family 5.003364e-01 0.301
R-HSA-201681 TCF dependent signaling in response to WNT 5.036259e-01 0.298
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 5.061396e-01 0.296
R-HSA-76009 Platelet Aggregation (Plug Formation) 5.061396e-01 0.296
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 5.079488e-01 0.294
R-HSA-5628897 TP53 Regulates Metabolic Genes 5.079488e-01 0.294
R-HSA-4420097 VEGFA-VEGFR2 Pathway 5.120814e-01 0.291
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 5.126809e-01 0.290
R-HSA-2299718 Condensation of Prophase Chromosomes 5.126809e-01 0.290
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 5.126809e-01 0.290
R-HSA-2262752 Cellular responses to stress 5.179416e-01 0.286
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 5.191360e-01 0.285
R-HSA-5693538 Homology Directed Repair 5.243422e-01 0.280
R-HSA-5620924 Intraflagellar transport 5.255059e-01 0.279
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 5.255059e-01 0.279
R-HSA-389356 Co-stimulation by CD28 5.255059e-01 0.279
R-HSA-9031628 NGF-stimulated transcription 5.255059e-01 0.279
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 5.255059e-01 0.279
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.283832e-01 0.277
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.283832e-01 0.277
R-HSA-73893 DNA Damage Bypass 5.317919e-01 0.274
R-HSA-68875 Mitotic Prophase 5.324009e-01 0.274
R-HSA-5658442 Regulation of RAS by GAPs 5.379950e-01 0.269
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.403664e-01 0.267
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.403664e-01 0.267
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5.441162e-01 0.264
R-HSA-9864848 Complex IV assembly 5.441162e-01 0.264
R-HSA-9816359 Maternal to zygotic transition (MZT) 5.443140e-01 0.264
R-HSA-73772 RNA Polymerase I Promoter Escape 5.501568e-01 0.260
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 5.501568e-01 0.260
R-HSA-6794361 Neurexins and neuroligins 5.501568e-01 0.260
R-HSA-194138 Signaling by VEGF 5.560153e-01 0.255
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 5.561176e-01 0.255
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 5.561176e-01 0.255
R-HSA-8948751 Regulation of PTEN stability and activity 5.561176e-01 0.255
R-HSA-389948 Co-inhibition by PD-1 5.578748e-01 0.253
R-HSA-72649 Translation initiation complex formation 5.619999e-01 0.250
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 5.619999e-01 0.250
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 5.670763e-01 0.246
R-HSA-376176 Signaling by ROBO receptors 5.670763e-01 0.246
R-HSA-73894 DNA Repair 5.704145e-01 0.244
R-HSA-72702 Ribosomal scanning and start codon recognition 5.735326e-01 0.241
R-HSA-193648 NRAGE signals death through JNK 5.735326e-01 0.241
R-HSA-209776 Metabolism of amine-derived hormones 5.735326e-01 0.241
R-HSA-2980766 Nuclear Envelope Breakdown 5.791851e-01 0.237
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.791851e-01 0.237
R-HSA-9843745 Adipogenesis 5.824862e-01 0.235
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 5.847631e-01 0.233
R-HSA-9772572 Early SARS-CoV-2 Infection Events 5.847631e-01 0.233
R-HSA-5673001 RAF/MAP kinase cascade 5.890820e-01 0.230
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 5.902674e-01 0.229
R-HSA-194441 Metabolism of non-coding RNA 5.902674e-01 0.229
R-HSA-191859 snRNP Assembly 5.902674e-01 0.229
R-HSA-429914 Deadenylation-dependent mRNA decay 5.902674e-01 0.229
R-HSA-1660661 Sphingolipid de novo biosynthesis 5.956991e-01 0.225
R-HSA-168325 Viral Messenger RNA Synthesis 6.010592e-01 0.221
R-HSA-8939902 Regulation of RUNX2 expression and activity 6.010592e-01 0.221
R-HSA-1483257 Phospholipid metabolism 6.042118e-01 0.219
R-HSA-6784531 tRNA processing in the nucleus 6.063485e-01 0.217
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6.063485e-01 0.217
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 6.063485e-01 0.217
R-HSA-9707616 Heme signaling 6.063485e-01 0.217
R-HSA-9616222 Transcriptional regulation of granulopoiesis 6.063485e-01 0.217
R-HSA-186797 Signaling by PDGF 6.063485e-01 0.217
R-HSA-5684996 MAPK1/MAPK3 signaling 6.067007e-01 0.217
R-HSA-6790901 rRNA modification in the nucleus and cytosol 6.115680e-01 0.214
R-HSA-373755 Semaphorin interactions 6.115680e-01 0.214
R-HSA-195721 Signaling by WNT 6.116502e-01 0.213
R-HSA-418990 Adherens junctions interactions 6.141299e-01 0.212
R-HSA-9664417 Leishmania phagocytosis 6.182648e-01 0.209
R-HSA-9664422 FCGR3A-mediated phagocytosis 6.182648e-01 0.209
R-HSA-9664407 Parasite infection 6.182648e-01 0.209
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 6.217107e-01 0.206
R-HSA-1632852 Macroautophagy 6.217107e-01 0.206
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 6.218012e-01 0.206
R-HSA-1234174 Cellular response to hypoxia 6.218012e-01 0.206
R-HSA-913531 Interferon Signaling 6.245076e-01 0.204
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.285309e-01 0.202
R-HSA-162582 Signal Transduction 6.316685e-01 0.200
R-HSA-5693606 DNA Double Strand Break Response 6.317661e-01 0.199
R-HSA-9830369 Kidney development 6.317661e-01 0.199
R-HSA-8856828 Clathrin-mediated endocytosis 6.319051e-01 0.199
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 6.366501e-01 0.196
R-HSA-5218859 Regulated Necrosis 6.366501e-01 0.196
R-HSA-9705683 SARS-CoV-2-host interactions 6.417492e-01 0.193
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 6.462255e-01 0.190
R-HSA-69202 Cyclin E associated events during G1/S transition 6.462255e-01 0.190
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.484197e-01 0.188
R-HSA-427413 NoRC negatively regulates rRNA expression 6.509186e-01 0.186
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 6.509186e-01 0.186
R-HSA-453276 Regulation of mitotic cell cycle 6.509186e-01 0.186
R-HSA-5578749 Transcriptional regulation by small RNAs 6.555497e-01 0.183
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.555497e-01 0.183
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 6.555497e-01 0.183
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 6.601197e-01 0.180
R-HSA-4086398 Ca2+ pathway 6.601197e-01 0.180
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 6.601197e-01 0.180
R-HSA-1852241 Organelle biogenesis and maintenance 6.635190e-01 0.178
R-HSA-5693532 DNA Double-Strand Break Repair 6.643443e-01 0.178
R-HSA-69473 G2/M DNA damage checkpoint 6.646293e-01 0.177
R-HSA-1226099 Signaling by FGFR in disease 6.646293e-01 0.177
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 6.690794e-01 0.175
R-HSA-168273 Influenza Viral RNA Transcription and Replication 6.705504e-01 0.174
R-HSA-1980143 Signaling by NOTCH1 6.734707e-01 0.172
R-HSA-9612973 Autophagy 6.736187e-01 0.172
R-HSA-9610379 HCMV Late Events 6.766639e-01 0.170
R-HSA-9711097 Cellular response to starvation 6.796860e-01 0.168
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 6.796860e-01 0.168
R-HSA-416482 G alpha (12/13) signalling events 6.820800e-01 0.166
R-HSA-877300 Interferon gamma signaling 6.826851e-01 0.166
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 6.862995e-01 0.163
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 6.904633e-01 0.161
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 6.904633e-01 0.161
R-HSA-8953897 Cellular responses to stimuli 6.909044e-01 0.161
R-HSA-109581 Apoptosis 6.915456e-01 0.160
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.986266e-01 0.156
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 6.986266e-01 0.156
R-HSA-421270 Cell-cell junction organization 6.999119e-01 0.155
R-HSA-1266738 Developmental Biology 7.037509e-01 0.153
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 7.065756e-01 0.151
R-HSA-6802957 Oncogenic MAPK signaling 7.104715e-01 0.148
R-HSA-6794362 Protein-protein interactions at synapses 7.104715e-01 0.148
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.143159e-01 0.146
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 7.143159e-01 0.146
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.169132e-01 0.145
R-HSA-5683057 MAPK family signaling cascades 7.205016e-01 0.142
R-HSA-438064 Post NMDA receptor activation events 7.218529e-01 0.142
R-HSA-9694516 SARS-CoV-2 Infection 7.244262e-01 0.140
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.249727e-01 0.140
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.249727e-01 0.140
R-HSA-156902 Peptide chain elongation 7.255469e-01 0.139
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.276159e-01 0.138
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 7.302378e-01 0.137
R-HSA-9678108 SARS-CoV-1 Infection 7.302378e-01 0.137
R-HSA-112310 Neurotransmitter release cycle 7.327889e-01 0.135
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 7.363383e-01 0.133
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 7.398408e-01 0.131
R-HSA-168255 Influenza Infection 7.405128e-01 0.130
R-HSA-156842 Eukaryotic Translation Elongation 7.432969e-01 0.129
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 7.467073e-01 0.127
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 7.533935e-01 0.123
R-HSA-72689 Formation of a pool of free 40S subunits 7.566704e-01 0.121
R-HSA-72764 Eukaryotic Translation Termination 7.566704e-01 0.121
R-HSA-1296071 Potassium Channels 7.599040e-01 0.119
R-HSA-5607764 CLEC7A (Dectin-1) signaling 7.599040e-01 0.119
R-HSA-8868773 rRNA processing in the nucleus and cytosol 7.624186e-01 0.118
R-HSA-422475 Axon guidance 7.658350e-01 0.116
R-HSA-8957275 Post-translational protein phosphorylation 7.662434e-01 0.116
R-HSA-9614085 FOXO-mediated transcription 7.693503e-01 0.114
R-HSA-168898 Toll-like Receptor Cascades 7.693578e-01 0.114
R-HSA-70171 Glycolysis 7.724161e-01 0.112
R-HSA-9020702 Interleukin-1 signaling 7.754414e-01 0.110
R-HSA-2408557 Selenocysteine synthesis 7.754414e-01 0.110
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 7.784266e-01 0.109
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 7.784266e-01 0.109
R-HSA-9609690 HCMV Early Events 7.805330e-01 0.108
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.805330e-01 0.108
R-HSA-192823 Viral mRNA Translation 7.813724e-01 0.107
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 7.842791e-01 0.106
R-HSA-5619507 Activation of HOX genes during differentiation 7.871474e-01 0.104
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 7.871474e-01 0.104
R-HSA-9692914 SARS-CoV-1-host interactions 7.927706e-01 0.101
R-HSA-1483206 Glycerophospholipid biosynthesis 7.953832e-01 0.099
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 7.955265e-01 0.099
R-HSA-211000 Gene Silencing by RNA 7.955265e-01 0.099
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.982459e-01 0.098
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.982459e-01 0.098
R-HSA-5357801 Programmed Cell Death 8.014723e-01 0.096
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.087682e-01 0.092
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.087682e-01 0.092
R-HSA-1483249 Inositol phosphate metabolism 8.087682e-01 0.092
R-HSA-9675108 Nervous system development 8.152217e-01 0.089
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 8.162999e-01 0.088
R-HSA-72737 Cap-dependent Translation Initiation 8.235362e-01 0.084
R-HSA-72613 Eukaryotic Translation Initiation 8.235362e-01 0.084
R-HSA-70326 Glucose metabolism 8.258847e-01 0.083
R-HSA-9007101 Rab regulation of trafficking 8.258847e-01 0.083
R-HSA-2980736 Peptide hormone metabolism 8.258847e-01 0.083
R-HSA-8951664 Neddylation 8.313134e-01 0.080
R-HSA-3371556 Cellular response to heat stress 8.349717e-01 0.078
R-HSA-162909 Host Interactions of HIV factors 8.414757e-01 0.075
R-HSA-109582 Hemostasis 8.429843e-01 0.074
R-HSA-69206 G1/S Transition 8.456693e-01 0.073
R-HSA-72312 rRNA processing 8.494291e-01 0.071
R-HSA-114608 Platelet degranulation 8.497525e-01 0.071
R-HSA-69481 G2/M Checkpoints 8.497525e-01 0.071
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.500131e-01 0.071
R-HSA-1474228 Degradation of the extracellular matrix 8.613680e-01 0.065
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 8.632151e-01 0.064
R-HSA-1280215 Cytokine Signaling in Immune system 8.669838e-01 0.062
R-HSA-163685 Integration of energy metabolism 8.703617e-01 0.060
R-HSA-3858494 Beta-catenin independent WNT signaling 8.703617e-01 0.060
R-HSA-9018519 Estrogen-dependent gene expression 8.703617e-01 0.060
R-HSA-9948299 Ribosome-associated quality control 8.737943e-01 0.059
R-HSA-9609646 HCMV Infection 8.753004e-01 0.058
R-HSA-9679506 SARS-CoV Infections 8.832895e-01 0.054
R-HSA-453279 Mitotic G1 phase and G1/S transition 8.881553e-01 0.052
R-HSA-69242 S Phase 8.911188e-01 0.050
R-HSA-112316 Neuronal System 8.917318e-01 0.050
R-HSA-9758941 Gastrulation 8.925711e-01 0.049
R-HSA-9679191 Potential therapeutics for SARS 8.940042e-01 0.049
R-HSA-446652 Interleukin-1 family signaling 8.968134e-01 0.047
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.968134e-01 0.047
R-HSA-9711123 Cellular response to chemical stress 8.970350e-01 0.047
R-HSA-1989781 PPARA activates gene expression 9.008889e-01 0.045
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 9.035165e-01 0.044
R-HSA-9006936 Signaling by TGFB family members 9.073284e-01 0.042
R-HSA-9658195 Leishmania infection 9.104892e-01 0.041
R-HSA-9824443 Parasitic Infection Pathways 9.104892e-01 0.041
R-HSA-2408522 Selenoamino acid metabolism 9.121788e-01 0.040
R-HSA-5619102 SLC transporter disorders 9.156499e-01 0.038
R-HSA-72306 tRNA processing 9.200667e-01 0.036
R-HSA-5621481 C-type lectin receptors (CLRs) 9.211344e-01 0.036
R-HSA-611105 Respiratory electron transport 9.282213e-01 0.032
R-HSA-449147 Signaling by Interleukins 9.332148e-01 0.030
R-HSA-5617833 Cilium Assembly 9.389265e-01 0.027
R-HSA-112315 Transmission across Chemical Synapses 9.435584e-01 0.025
R-HSA-9824446 Viral Infection Pathways 9.445739e-01 0.025
R-HSA-199991 Membrane Trafficking 9.448754e-01 0.025
R-HSA-428157 Sphingolipid metabolism 9.473366e-01 0.023
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 9.552014e-01 0.020
R-HSA-68882 Mitotic Anaphase 9.575539e-01 0.019
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.581225e-01 0.019
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.648602e-01 0.016
R-HSA-597592 Post-translational protein modification 9.660210e-01 0.015
R-HSA-8939211 ESR-mediated signaling 9.680293e-01 0.014
R-HSA-202733 Cell surface interactions at the vascular wall 9.680293e-01 0.014
R-HSA-157118 Signaling by NOTCH 9.692988e-01 0.014
R-HSA-68886 M Phase 9.713631e-01 0.013
R-HSA-5619115 Disorders of transmembrane transporters 9.720693e-01 0.012
R-HSA-8953854 Metabolism of RNA 9.731397e-01 0.012
R-HSA-1280218 Adaptive Immune System 9.750927e-01 0.011
R-HSA-69620 Cell Cycle Checkpoints 9.759286e-01 0.011
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 9.818829e-01 0.008
R-HSA-5653656 Vesicle-mediated transport 9.868463e-01 0.006
R-HSA-8957322 Metabolism of steroids 9.901581e-01 0.004
R-HSA-1474244 Extracellular matrix organization 9.910507e-01 0.004
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.921879e-01 0.003
R-HSA-9006931 Signaling by Nuclear Receptors 9.942085e-01 0.003
R-HSA-196854 Metabolism of vitamins and cofactors 9.942868e-01 0.002
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.962554e-01 0.002
R-HSA-425407 SLC-mediated transmembrane transport 9.964055e-01 0.002
R-HSA-5663205 Infectious disease 9.965099e-01 0.002
R-HSA-69278 Cell Cycle, Mitotic 9.967814e-01 0.001
R-HSA-418594 G alpha (i) signalling events 9.968641e-01 0.001
R-HSA-8978868 Fatty acid metabolism 9.968641e-01 0.001
R-HSA-1640170 Cell Cycle 9.969135e-01 0.001
R-HSA-72766 Translation 9.976782e-01 0.001
R-HSA-168249 Innate Immune System 9.978027e-01 0.001
R-HSA-71291 Metabolism of amino acids and derivatives 9.983020e-01 0.001
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.983732e-01 0.001
R-HSA-388396 GPCR downstream signalling 9.985503e-01 0.001
R-HSA-168256 Immune System 9.986205e-01 0.001
R-HSA-392499 Metabolism of proteins 9.994324e-01 0.000
R-HSA-372790 Signaling by GPCR 9.994514e-01 0.000
R-HSA-556833 Metabolism of lipids 9.995181e-01 0.000
R-HSA-500792 GPCR ligand binding 9.997424e-01 0.000
R-HSA-1643685 Disease 9.998086e-01 0.000
R-HSA-382551 Transport of small molecules 9.999989e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.802 0.698 1 0.853
CDK19CDK19 0.795 0.750 1 0.848
CDK18CDK18 0.790 0.711 1 0.869
CDK8CDK8 0.785 0.740 1 0.814
P38BP38B 0.785 0.779 1 0.837
P38DP38D 0.783 0.702 1 0.901
ERK1ERK1 0.783 0.743 1 0.852
KISKIS 0.783 0.569 1 0.795
MAKMAK 0.783 0.709 -2 0.759
CDK17CDK17 0.780 0.684 1 0.895
P38GP38G 0.780 0.690 1 0.903
HIPK4HIPK4 0.777 0.625 1 0.560
CDK7CDK7 0.776 0.698 1 0.822
CDK3CDK3 0.773 0.588 1 0.890
DYRK2DYRK2 0.772 0.643 1 0.772
CDK1CDK1 0.772 0.654 1 0.850
JNK2JNK2 0.770 0.678 1 0.863
DYRK4DYRK4 0.768 0.615 1 0.862
CDK16CDK16 0.768 0.655 1 0.883
P38AP38A 0.767 0.762 1 0.772
CDK5CDK5 0.766 0.649 1 0.797
CDK13CDK13 0.765 0.622 1 0.843
CDK12CDK12 0.764 0.622 1 0.862
HIPK1HIPK1 0.762 0.581 1 0.753
DYRK1ADYRK1A 0.761 0.604 1 0.729
JNK3JNK3 0.756 0.648 1 0.837
DYRK1BDYRK1B 0.756 0.576 1 0.820
CDK14CDK14 0.755 0.629 1 0.830
CDK9CDK9 0.752 0.591 1 0.836
HIPK3HIPK3 0.752 0.573 1 0.721
CDK10CDK10 0.751 0.576 1 0.847
ERK2ERK2 0.748 0.655 1 0.806
CLK3CLK3 0.747 0.438 1 0.524
CDK4CDK4 0.746 0.626 1 0.868
JNK1JNK1 0.745 0.589 1 0.863
CDK6CDK6 0.744 0.595 1 0.846
MOKMOK 0.744 0.566 1 0.651
ICKICK 0.743 0.577 -3 0.824
CDKL5CDKL5 0.738 0.394 -3 0.797
DYRK3DYRK3 0.737 0.440 1 0.716
SRPK1SRPK1 0.736 0.289 -3 0.770
ERK5ERK5 0.731 0.389 1 0.487
NLKNLK 0.731 0.543 1 0.563
CDK2CDK2 0.726 0.437 1 0.731
SRPK2SRPK2 0.725 0.243 -3 0.695
CLK2CLK2 0.722 0.293 -3 0.755
CDKL1CDKL1 0.720 0.314 -3 0.799
PRP4PRP4 0.715 0.385 -3 0.754
CLK1CLK1 0.714 0.279 -3 0.747
MTORMTOR 0.713 0.226 1 0.357
CLK4CLK4 0.711 0.251 -3 0.762
NDR2NDR2 0.706 0.093 -3 0.803
SRPK3SRPK3 0.705 0.185 -3 0.733
MPSK1MPSK1 0.705 0.321 1 0.247
CHAK2CHAK2 0.704 0.090 -1 0.796
AURCAURC 0.701 0.016 -2 0.210
COTCOT 0.701 -0.057 2 0.818
CDC7CDC7 0.701 0.013 1 0.192
TBK1TBK1 0.700 0.004 1 0.144
PIM3PIM3 0.700 0.032 -3 0.814
MOSMOS 0.699 0.068 1 0.234
ATRATR 0.698 0.040 1 0.235
ERK7ERK7 0.697 0.231 2 0.528
GRK1GRK1 0.695 0.034 -2 0.294
PRPKPRPK 0.694 0.013 -1 0.811
SKMLCKSKMLCK 0.694 0.021 -2 0.322
PRKD1PRKD1 0.694 0.000 -3 0.800
GRK7GRK7 0.691 0.072 1 0.208
IKKEIKKE 0.690 -0.085 1 0.141
IKKBIKKB 0.690 -0.155 -2 0.229
IKKAIKKA 0.689 -0.046 -2 0.253
PRKD2PRKD2 0.688 -0.008 -3 0.766
NDR1NDR1 0.687 -0.028 -3 0.798
PKACBPKACB 0.686 -0.001 -2 0.201
MLK2MLK2 0.686 0.086 2 0.795
PKACGPKACG 0.686 -0.041 -2 0.238
PAK1PAK1 0.686 -0.006 -2 0.319
PDHK4PDHK4 0.685 -0.108 1 0.239
WNK1WNK1 0.684 -0.052 -2 0.345
CAMK1BCAMK1B 0.684 -0.057 -3 0.830
GCN2GCN2 0.683 -0.179 2 0.786
PIM1PIM1 0.683 0.014 -3 0.776
MNK2MNK2 0.683 -0.014 -2 0.258
RAF1RAF1 0.683 -0.147 1 0.172
MARK4MARK4 0.683 -0.037 4 0.838
PAK6PAK6 0.682 -0.021 -2 0.239
RSK2RSK2 0.682 -0.020 -3 0.778
LATS2LATS2 0.682 -0.010 -5 0.737
CAMLCKCAMLCK 0.682 -0.018 -2 0.290
PAK3PAK3 0.682 -0.038 -2 0.292
ULK2ULK2 0.682 -0.167 2 0.795
MLK3MLK3 0.681 0.060 2 0.700
NUAK2NUAK2 0.681 -0.022 -3 0.818
P90RSKP90RSK 0.681 -0.005 -3 0.775
BMPR2BMPR2 0.681 -0.154 -2 0.287
TGFBR2TGFBR2 0.681 -0.114 -2 0.219
PKG2PKG2 0.680 -0.028 -2 0.213
PRKXPRKX 0.680 0.010 -3 0.694
PKCDPKCD 0.680 -0.017 2 0.746
DAPK2DAPK2 0.680 -0.028 -3 0.828
PDHK1PDHK1 0.680 -0.132 1 0.211
RSK3RSK3 0.679 -0.026 -3 0.764
MST4MST4 0.679 -0.066 2 0.787
PKN3PKN3 0.679 -0.050 -3 0.797
NEK6NEK6 0.679 -0.093 -2 0.252
NIKNIK 0.679 -0.075 -3 0.823
AMPKA1AMPKA1 0.678 -0.038 -3 0.815
IRE1IRE1 0.678 -0.033 1 0.178
GRK5GRK5 0.677 -0.118 -3 0.790
AMPKA2AMPKA2 0.677 -0.011 -3 0.792
MASTLMASTL 0.677 -0.106 -2 0.285
MAPKAPK2MAPKAPK2 0.677 -0.017 -3 0.727
AURBAURB 0.677 -0.043 -2 0.202
NIM1NIM1 0.676 -0.070 3 0.704
MAPKAPK3MAPKAPK3 0.676 -0.049 -3 0.752
MNK1MNK1 0.676 -0.023 -2 0.258
RIPK3RIPK3 0.676 -0.069 3 0.667
PKCZPKCZ 0.676 0.007 2 0.765
PKCAPKCA 0.676 0.015 2 0.690
GSK3AGSK3A 0.676 0.169 4 0.405
LATS1LATS1 0.675 0.042 -3 0.809
RSK4RSK4 0.675 0.017 -3 0.749
MLK1MLK1 0.674 -0.081 2 0.768
CAMK2GCAMK2G 0.674 -0.121 2 0.789
QSKQSK 0.673 -0.019 4 0.818
PKN2PKN2 0.673 -0.095 -3 0.801
TSSK1TSSK1 0.673 -0.052 -3 0.835
P70S6KBP70S6KB 0.673 -0.038 -3 0.776
WNK3WNK3 0.673 -0.131 1 0.173
PKCGPKCG 0.673 -0.019 2 0.705
SGK3SGK3 0.672 -0.014 -3 0.757
SMG1SMG1 0.672 -0.042 1 0.220
PRKD3PRKD3 0.672 -0.031 -3 0.741
PHKG1PHKG1 0.672 -0.039 -3 0.787
CAMK2DCAMK2D 0.672 -0.090 -3 0.800
VRK2VRK2 0.672 0.108 1 0.279
AKT2AKT2 0.672 0.007 -3 0.708
PAK2PAK2 0.671 -0.052 -2 0.299
BCKDKBCKDK 0.671 -0.118 -1 0.731
PKCBPKCB 0.671 -0.023 2 0.684
CHAK1CHAK1 0.671 -0.052 2 0.842
BMPR1BBMPR1B 0.671 -0.081 1 0.166
ULK1ULK1 0.670 -0.161 -3 0.719
PINK1PINK1 0.670 0.050 1 0.389
PKACAPKACA 0.669 -0.021 -2 0.180
DLKDLK 0.669 -0.112 1 0.187
DSTYKDSTYK 0.669 -0.238 2 0.824
TGFBR1TGFBR1 0.669 -0.082 -2 0.238
TTBK2TTBK2 0.668 -0.130 2 0.753
ALK4ALK4 0.668 -0.094 -2 0.252
NUAK1NUAK1 0.667 -0.043 -3 0.759
MSK2MSK2 0.667 -0.047 -3 0.741
PIM2PIM2 0.667 0.001 -3 0.747
PAK5PAK5 0.667 -0.042 -2 0.234
BRSK2BRSK2 0.667 -0.030 -3 0.773
SIKSIK 0.667 -0.037 -3 0.732
NEK7NEK7 0.667 -0.230 -3 0.741
RIPK1RIPK1 0.667 -0.139 1 0.172
DNAPKDNAPK 0.667 -0.036 1 0.218
MELKMELK 0.667 -0.075 -3 0.772
TLK2TLK2 0.666 -0.087 1 0.164
AURAAURA 0.666 -0.062 -2 0.188
CK1ECK1E 0.666 0.001 -3 0.529
IRE2IRE2 0.666 -0.044 2 0.736
BUB1BUB1 0.666 0.072 -5 0.736
NEK9NEK9 0.665 -0.164 2 0.811
TSSK2TSSK2 0.665 -0.130 -5 0.790
MARK3MARK3 0.665 -0.036 4 0.781
PKRPKR 0.664 -0.075 1 0.195
MSK1MSK1 0.664 -0.039 -3 0.744
PAK4PAK4 0.664 -0.035 -2 0.239
BRSK1BRSK1 0.664 -0.033 -3 0.761
QIKQIK 0.663 -0.111 -3 0.789
CAMK2ACAMK2A 0.663 -0.025 2 0.744
ATMATM 0.663 -0.080 1 0.201
PLK4PLK4 0.663 -0.095 2 0.696
HUNKHUNK 0.663 -0.211 2 0.801
MLK4MLK4 0.663 -0.030 2 0.690
AKT1AKT1 0.663 -0.018 -3 0.719
DCAMKL1DCAMKL1 0.662 -0.041 -3 0.764
GRK2GRK2 0.662 -0.090 -2 0.240
GRK4GRK4 0.661 -0.168 -2 0.267
PKCHPKCH 0.661 -0.064 2 0.692
YSK4YSK4 0.661 -0.137 1 0.154
TAO3TAO3 0.660 0.004 1 0.203
MYLK4MYLK4 0.659 -0.074 -2 0.242
GRK6GRK6 0.659 -0.171 1 0.175
MARK2MARK2 0.658 -0.061 4 0.755
MAP3K15MAP3K15 0.658 0.056 1 0.177
MEK1MEK1 0.658 -0.163 2 0.820
AKT3AKT3 0.658 0.002 -3 0.662
CAMK4CAMK4 0.658 -0.150 -3 0.779
ANKRD3ANKRD3 0.658 -0.231 1 0.194
PASKPASK 0.658 0.020 -3 0.829
FAM20CFAM20C 0.657 -0.035 2 0.574
ACVR2BACVR2B 0.657 -0.134 -2 0.221
CAMK2BCAMK2B 0.657 -0.084 2 0.740
WNK4WNK4 0.656 -0.076 -2 0.349
IRAK4IRAK4 0.656 -0.073 1 0.158
ACVR2AACVR2A 0.656 -0.143 -2 0.211
CK1DCK1D 0.656 -0.015 -3 0.482
MST3MST3 0.655 -0.065 2 0.790
LKB1LKB1 0.655 0.000 -3 0.747
PDK1PDK1 0.655 -0.023 1 0.212
NEK2NEK2 0.655 -0.155 2 0.806
SNRKSNRK 0.654 -0.134 2 0.761
PKCTPKCT 0.654 -0.066 2 0.702
SSTKSSTK 0.654 -0.084 4 0.812
PLK1PLK1 0.653 -0.196 -2 0.215
SGK1SGK1 0.653 0.019 -3 0.643
MEK5MEK5 0.652 -0.135 2 0.811
PHKG2PHKG2 0.652 -0.092 -3 0.774
DCAMKL2DCAMKL2 0.652 -0.056 -3 0.781
MAPKAPK5MAPKAPK5 0.651 -0.099 -3 0.698
CK1G1CK1G1 0.651 -0.057 -3 0.509
GSK3BGSK3B 0.651 0.029 4 0.398
PKCIPKCI 0.651 -0.064 2 0.723
CHK1CHK1 0.651 -0.104 -3 0.773
PKCEPKCE 0.651 -0.026 2 0.690
PBKPBK 0.651 0.006 1 0.217
MEKK2MEKK2 0.651 -0.116 2 0.786
MARK1MARK1 0.650 -0.088 4 0.795
PERKPERK 0.650 -0.170 -2 0.239
ALK2ALK2 0.650 -0.136 -2 0.232
SBKSBK 0.649 0.063 -3 0.610
GRK3GRK3 0.649 -0.098 -2 0.220
ZAKZAK 0.649 -0.150 1 0.164
MEKK1MEKK1 0.649 -0.139 1 0.181
HASPINHASPIN 0.648 0.055 -1 0.699
CAMK1GCAMK1G 0.648 -0.086 -3 0.746
NEK5NEK5 0.648 -0.126 1 0.177
BMPR1ABMPR1A 0.648 -0.110 1 0.152
DRAK1DRAK1 0.648 -0.141 1 0.164
MEKK6MEKK6 0.648 -0.045 1 0.184
GCKGCK 0.647 -0.019 1 0.184
P70S6KP70S6K 0.647 -0.058 -3 0.703
ROCK2ROCK2 0.646 -0.007 -3 0.767
KHS1KHS1 0.646 0.005 1 0.174
CK1A2CK1A2 0.646 -0.038 -3 0.485
SMMLCKSMMLCK 0.646 -0.081 -3 0.797
HGKHGK 0.645 -0.052 3 0.846
MRCKBMRCKB 0.645 -0.027 -3 0.731
BRAFBRAF 0.645 -0.163 -4 0.536
TAO2TAO2 0.645 -0.059 2 0.811
TNIKTNIK 0.645 -0.030 3 0.853
LRRK2LRRK2 0.645 -0.001 2 0.843
SLKSLK 0.643 -0.035 -2 0.246
PLK3PLK3 0.643 -0.156 2 0.771
NEK11NEK11 0.643 -0.103 1 0.198
LOKLOK 0.643 -0.064 -2 0.242
TLK1TLK1 0.643 -0.188 -2 0.245
PKG1PKG1 0.643 -0.063 -2 0.159
TTBK1TTBK1 0.643 -0.128 2 0.692
HRIHRI 0.643 -0.198 -2 0.256
DAPK3DAPK3 0.642 -0.064 -3 0.781
MEKK3MEKK3 0.642 -0.206 1 0.181
PKN1PKN1 0.642 -0.056 -3 0.723
CAMKK2CAMKK2 0.642 -0.141 -2 0.232
GAKGAK 0.641 -0.092 1 0.239
MRCKAMRCKA 0.641 -0.033 -3 0.734
HPK1HPK1 0.641 -0.077 1 0.185
KHS2KHS2 0.640 -0.014 1 0.188
CAMKK1CAMKK1 0.640 -0.203 -2 0.217
MINKMINK 0.639 -0.105 1 0.157
EEF2KEEF2K 0.638 -0.033 3 0.794
CAMK1DCAMK1D 0.638 -0.062 -3 0.677
NEK8NEK8 0.638 -0.179 2 0.809
NEK4NEK4 0.637 -0.151 1 0.158
STK33STK33 0.635 -0.106 2 0.681
DMPK1DMPK1 0.635 -0.014 -3 0.759
VRK1VRK1 0.635 -0.082 2 0.821
MST2MST2 0.634 -0.150 1 0.167
CHK2CHK2 0.634 -0.041 -3 0.660
DAPK1DAPK1 0.634 -0.079 -3 0.774
CAMK1ACAMK1A 0.633 -0.047 -3 0.669
CK2A2CK2A2 0.633 -0.086 1 0.147
NEK1NEK1 0.632 -0.120 1 0.157
LIMK2_TYRLIMK2_TYR 0.632 0.180 -3 0.824
PDHK3_TYRPDHK3_TYR 0.631 0.187 4 0.861
CRIKCRIK 0.630 -0.010 -3 0.726
YSK1YSK1 0.630 -0.103 2 0.780
ROCK1ROCK1 0.630 -0.041 -3 0.735
ASK1ASK1 0.628 -0.032 1 0.174
BIKEBIKE 0.628 -0.037 1 0.231
AAK1AAK1 0.627 -0.004 1 0.237
MST1MST1 0.627 -0.154 1 0.156
CK1ACK1A 0.626 -0.042 -3 0.396
TAK1TAK1 0.626 -0.209 1 0.160
IRAK1IRAK1 0.626 -0.245 -1 0.706
MEK2MEK2 0.625 -0.176 2 0.809
OSR1OSR1 0.625 -0.077 2 0.777
TESK1_TYRTESK1_TYR 0.624 0.080 3 0.837
PKMYT1_TYRPKMYT1_TYR 0.624 0.118 3 0.797
CK2A1CK2A1 0.624 -0.092 1 0.139
MYO3BMYO3B 0.623 -0.064 2 0.802
MAP2K4_TYRMAP2K4_TYR 0.621 0.044 -1 0.820
TAO1TAO1 0.621 -0.063 1 0.167
NEK3NEK3 0.621 -0.158 1 0.178
PLK2PLK2 0.621 -0.095 -3 0.690
PDHK4_TYRPDHK4_TYR 0.620 0.053 2 0.851
MYO3AMYO3A 0.619 -0.089 1 0.176
YANK3YANK3 0.618 -0.031 2 0.461
MAP2K7_TYRMAP2K7_TYR 0.618 -0.015 2 0.856
RIPK2RIPK2 0.617 -0.222 1 0.144
PDHK1_TYRPDHK1_TYR 0.616 0.030 -1 0.808
MAP2K6_TYRMAP2K6_TYR 0.616 0.002 -1 0.809
LIMK1_TYRLIMK1_TYR 0.613 0.028 2 0.854
TTKTTK 0.613 -0.132 -2 0.239
BMPR2_TYRBMPR2_TYR 0.612 -0.055 -1 0.792
JAK2JAK2 0.612 -0.025 1 0.203
CSF1RCSF1R 0.612 0.030 3 0.748
PINK1_TYRPINK1_TYR 0.611 -0.139 1 0.235
RETRET 0.611 -0.045 1 0.197
NEK10_TYRNEK10_TYR 0.610 -0.028 1 0.171
TNK2TNK2 0.610 0.030 3 0.706
MST1RMST1R 0.609 -0.020 3 0.768
EPHB4EPHB4 0.609 0.009 -1 0.752
ABL2ABL2 0.609 -0.002 -1 0.730
ALPHAK3ALPHAK3 0.608 -0.066 -1 0.692
TNK1TNK1 0.608 0.044 3 0.736
ROS1ROS1 0.607 -0.030 3 0.723
TXKTXK 0.607 0.004 1 0.164
JAK1JAK1 0.606 -0.012 1 0.173
TYK2TYK2 0.606 -0.130 1 0.182
EPHA6EPHA6 0.606 -0.046 -1 0.764
TNNI3K_TYRTNNI3K_TYR 0.606 -0.012 1 0.207
TYRO3TYRO3 0.606 -0.062 3 0.756
ABL1ABL1 0.605 -0.020 -1 0.729
YES1YES1 0.602 -0.047 -1 0.797
STLK3STLK3 0.601 -0.162 1 0.145
DDR1DDR1 0.600 -0.072 4 0.795
JAK3JAK3 0.599 -0.091 1 0.192
LCKLCK 0.599 -0.042 -1 0.762
FGFR1FGFR1 0.598 -0.030 3 0.696
FGRFGR 0.598 -0.125 1 0.175
FGFR2FGFR2 0.598 -0.037 3 0.716
ITKITK 0.597 -0.058 -1 0.735
METMET 0.596 -0.040 3 0.743
KDRKDR 0.596 -0.061 3 0.694
KITKIT 0.595 -0.075 3 0.741
BLKBLK 0.595 -0.046 -1 0.761
PDGFRBPDGFRB 0.595 -0.119 3 0.754
HCKHCK 0.594 -0.099 -1 0.762
DDR2DDR2 0.593 0.031 3 0.654
EPHA4EPHA4 0.593 -0.042 2 0.763
FERFER 0.593 -0.138 1 0.180
PDGFRAPDGFRA 0.593 -0.088 3 0.753
FLT3FLT3 0.591 -0.129 3 0.754
MERTKMERTK 0.591 -0.072 3 0.718
SRMSSRMS 0.591 -0.103 1 0.156
TEKTEK 0.591 -0.040 3 0.670
EPHB1EPHB1 0.591 -0.090 1 0.159
INSRRINSRR 0.591 -0.114 3 0.676
WEE1_TYRWEE1_TYR 0.590 -0.078 -1 0.701
EPHB2EPHB2 0.590 -0.081 -1 0.726
EPHB3EPHB3 0.590 -0.087 -1 0.734
AXLAXL 0.590 -0.099 3 0.716
FYNFYN 0.589 -0.049 -1 0.744
BMXBMX 0.589 -0.059 -1 0.663
YANK2YANK2 0.588 -0.049 2 0.468
CK1G3CK1G3 0.587 -0.076 -3 0.354
PTK2BPTK2B 0.586 -0.045 -1 0.726
FGFR3FGFR3 0.585 -0.068 3 0.683
FRKFRK 0.585 -0.084 -1 0.762
ALKALK 0.585 -0.092 3 0.652
BTKBTK 0.584 -0.128 -1 0.718
EPHA1EPHA1 0.583 -0.075 3 0.725
EPHA7EPHA7 0.582 -0.054 2 0.777
PTK6PTK6 0.582 -0.132 -1 0.678
LTKLTK 0.581 -0.112 3 0.671
CSKCSK 0.581 -0.040 2 0.786
TECTEC 0.581 -0.113 -1 0.689
EGFREGFR 0.580 -0.085 1 0.142
NTRK3NTRK3 0.580 -0.100 -1 0.687
SRCSRC 0.580 -0.083 -1 0.747
INSRINSR 0.580 -0.104 3 0.661
MATKMATK 0.580 -0.079 -1 0.654
FLT1FLT1 0.579 -0.131 -1 0.719
ERBB2ERBB2 0.579 -0.147 1 0.167
EPHA3EPHA3 0.578 -0.097 2 0.756
NTRK1NTRK1 0.578 -0.161 -1 0.730
CK1G2CK1G2 0.578 -0.072 -3 0.435
LYNLYN 0.577 -0.112 3 0.649
FGFR4FGFR4 0.576 -0.080 -1 0.679
NTRK2NTRK2 0.576 -0.164 3 0.685
ZAP70ZAP70 0.575 -0.037 -1 0.603
FLT4FLT4 0.575 -0.145 3 0.671
EPHA8EPHA8 0.574 -0.081 -1 0.705
SYKSYK 0.573 -0.090 -1 0.663
MUSKMUSK 0.573 -0.110 1 0.132
PTK2PTK2 0.572 -0.059 -1 0.686
EPHA5EPHA5 0.571 -0.103 2 0.752
ERBB4ERBB4 0.568 -0.079 1 0.145
IGF1RIGF1R 0.562 -0.125 3 0.587
EPHA2EPHA2 0.561 -0.097 -1 0.666
FESFES 0.552 -0.111 -1 0.644