Motif 262 (n=118)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP49 | CCDC187 | S592 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A0A0C4DFX4 | None | S255 | ochoa | Snf2 related CREBBP activator protein | None |
| A1L390 | PLEKHG3 | S962 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A4D1S0 | KLRG2 | S47 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
| A8K0Z3 | WASHC1 | S345 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S358 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S343 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| H0Y626 | None | S31 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O00512 | BCL9 | S917 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14980 | XPO1 | S391 | ochoa|psp | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15014 | ZNF609 | S454 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O43149 | ZZEF1 | S1475 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O60292 | SIPA1L3 | S1385 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75061 | DNAJC6 | S570 | ochoa|psp | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75122 | CLASP2 | S507 | ochoa|psp | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75122 | CLASP2 | S1029 | ochoa|psp | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75128 | COBL | S815 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75581 | LRP6 | S1508 | ochoa | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
| O94887 | FARP2 | S480 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95155 | UBE4B | S311 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95359 | TACC2 | S559 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95361 | TRIM16 | S31 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95425 | SVIL | S263 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95503 | CBX6 | S280 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95630 | STAMBP | S247 | psp | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}. |
| O95785 | WIZ | S1017 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95817 | BAG3 | S279 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P0CG12 | DERPC | S70 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
| P11940 | PABPC1 | Y382 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P17600 | SYN1 | S665 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18031 | PTPN1 | S205 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18848 | ATF4 | S215 | psp | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:16682973, PubMed:17684156, PubMed:31023583, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:31023583, PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:31023583, PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}. |
| P19419 | ELK1 | S202 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P28290 | ITPRID2 | T1140 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P33076 | CIITA | S288 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P35712 | SOX6 | S411 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P47974 | ZFP36L2 | S59 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P50616 | TOB1 | S152 | ochoa|psp | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P53814 | SMTN | S341 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P78347 | GTF2I | S674 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q0JRZ9 | FCHO2 | S517 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12769 | NUP160 | S1157 | ochoa|psp | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}. |
| Q12789 | GTF3C1 | S1856 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12802 | AKAP13 | S2728 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13415 | ORC1 | S199 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13459 | MYO9B | S1242 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13796 | SHROOM2 | S1173 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13950 | RUNX2 | S275 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14526 | HIC1 | S270 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14814 | MEF2D | S219 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q2TB10 | ZNF800 | S462 | ochoa | Zinc finger protein 800 | May be involved in transcriptional regulation. |
| Q4KMP7 | TBC1D10B | S132 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5PRF9 | SAMD4B | S252 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5TGY3 | AHDC1 | S1011 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VST9 | OBSCN | S136 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT52 | RPRD2 | S440 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q66K74 | MAP1S | S770 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6UUV7 | CRTC3 | S375 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6VEQ5 | WASH2P | S345 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6VY07 | PACS1 | S781 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6W2J9 | BCOR | S336 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZRS2 | SRCAP | S274 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZUM4 | ARHGAP27 | Y93 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q70EL1 | USP54 | S958 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q71RC2 | LARP4 | S647 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q76L83 | ASXL2 | S648 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z591 | AKNA | S1123 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z7K6 | CENPV | S47 | ochoa | Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6) | Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269|PubMed:18772885}. |
| Q86UU0 | BCL9L | S975 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S539 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86X29 | LSR | S512 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q8IV36 | HID1 | S679 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8N344 | MIER2 | S467 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N3F8 | MICALL1 | S520 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N9M5 | TMEM102 | S218 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8ND56 | LSM14A | S227 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDF8 | TENT4B | S56 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8TB24 | RIN3 | S524 | ochoa | Ras and Rab interactor 3 (Ras interaction/interference protein 3) | Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}. |
| Q8TEK3 | DOT1L | S1039 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEQ6 | GEMIN5 | S1315 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8WXF1 | PSPC1 | S477 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Q92793 | CREBBP | S980 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969V6 | MRTFA | S312 | ochoa|psp | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96BF3 | TMIGD2 | S186 | psp | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96FS4 | SIPA1 | S839 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96KR1 | ZFR | T550 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96KS0 | EGLN2 | S74 | ochoa | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96L73 | NSD1 | S2369 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96L91 | EP400 | S736 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96S97 | MYADM | S22 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q96T58 | SPEN | S2493 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99504 | EYA3 | S262 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99958 | FOXC2 | S251 | psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQG0 | MYBBP1A | S1248 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9H6A9 | PCNX3 | S246 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6K1 | ILRUN | S272 | ochoa | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9H6K5 | PRR36 | S308 | ochoa | Proline-rich protein 36 | None |
| Q9HCD6 | TANC2 | S1560 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCK8 | CHD8 | S2519 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPE2 | NGRN | S243 | ochoa | Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G) | Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. {ECO:0000269|PubMed:27667664}. |
| Q9NQA3 | WASH6P | S327 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NTZ6 | RBM12 | S424 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NUA8 | ZBTB40 | S190 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NUQ6 | SPATS2L | S392 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NYD6 | HOXC10 | S210 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NZ71 | RTEL1 | S779 | ochoa | Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like) | A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:18957201, ECO:0000269|PubMed:23453664, ECO:0000269|PubMed:24009516}. |
| Q9P107 | GMIP | S425 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P206 | NHSL3 | S862 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P246 | STIM2 | S523 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9UER7 | DAXX | S690 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UGP4 | LIMD1 | S353 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UPN3 | MACF1 | S7292 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UQ35 | SRRM2 | T2125 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y4B5 | MTCL1 | S196 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F3 | MARF1 | S66 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| O60664 | PLIN3 | S225 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| Q99504 | EYA3 | S138 | PSP | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| P12830 | CDH1 | S146 | SIGNOR | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000002 | 5.770 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.000017 | 4.768 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000102 | 3.991 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.000231 | 3.636 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.001094 | 2.961 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.001481 | 2.829 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.002010 | 2.697 |
| R-HSA-9707616 | Heme signaling | 0.002483 | 2.605 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.003814 | 2.419 |
| R-HSA-195721 | Signaling by WNT | 0.004077 | 2.390 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.004951 | 2.305 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.005713 | 2.243 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.006101 | 2.215 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.009250 | 2.034 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.009250 | 2.034 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.015773 | 1.802 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.015773 | 1.802 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.015773 | 1.802 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.015773 | 1.802 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.015773 | 1.802 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.015773 | 1.802 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.023567 | 1.628 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.046582 | 1.332 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.054134 | 1.267 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.061626 | 1.210 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.061626 | 1.210 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.061626 | 1.210 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.069059 | 1.161 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.076434 | 1.117 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.083751 | 1.077 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.091010 | 1.041 |
| R-HSA-9613354 | Lipophagy | 0.091010 | 1.041 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.098213 | 1.008 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.021262 | 1.672 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.105358 | 0.977 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.112448 | 0.949 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.112448 | 0.949 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.119482 | 0.923 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.140253 | 0.853 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.140253 | 0.853 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.147068 | 0.832 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.018060 | 1.743 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.173797 | 0.760 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.060616 | 1.217 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.067085 | 1.173 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.193296 | 0.714 |
| R-HSA-429947 | Deadenylation of mRNA | 0.212339 | 0.673 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.218587 | 0.660 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.039647 | 1.402 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.039647 | 1.402 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.099932 | 1.000 |
| R-HSA-191859 | snRNP Assembly | 0.099932 | 1.000 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.237037 | 0.625 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.243091 | 0.614 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.249097 | 0.604 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.255055 | 0.593 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.255055 | 0.593 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.266832 | 0.574 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.266832 | 0.574 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.272651 | 0.564 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.272651 | 0.564 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.284152 | 0.546 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.284152 | 0.546 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.090355 | 1.044 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.128224 | 0.892 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.197026 | 0.705 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.197026 | 0.705 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.102424 | 0.990 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.126460 | 0.898 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.046450 | 1.333 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.030402 | 1.517 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.112448 | 0.949 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.153829 | 0.813 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.199694 | 0.700 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.224786 | 0.648 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.249097 | 0.604 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.083751 | 1.077 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.153829 | 0.813 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.080661 | 1.093 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.133554 | 0.874 |
| R-HSA-381042 | PERK regulates gene expression | 0.044540 | 1.351 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.119482 | 0.923 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.230936 | 0.637 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.022691 | 1.644 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.050358 | 1.298 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.244631 | 0.611 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.232572 | 0.633 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.054134 | 1.267 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.160538 | 0.794 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.020907 | 1.680 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.249097 | 0.604 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 0.112448 | 0.949 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.037210 | 1.429 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.224786 | 0.648 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.237037 | 0.625 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.093454 | 1.029 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.112448 | 0.949 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.040812 | 1.389 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.056432 | 1.248 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.059353 | 1.227 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.054380 | 1.265 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.250140 | 0.602 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.061626 | 1.210 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.112448 | 0.949 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.126460 | 0.898 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.032053 | 1.494 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.147068 | 0.832 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.160538 | 0.794 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.167193 | 0.777 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.199694 | 0.700 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.136238 | 0.866 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.278424 | 0.555 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.289834 | 0.538 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.247208 | 0.607 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.289834 | 0.538 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.167193 | 0.777 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.289834 | 0.538 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.266832 | 0.574 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.119482 | 0.923 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.152164 | 0.818 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.197744 | 0.704 |
| R-HSA-9609690 | HCMV Early Events | 0.244631 | 0.611 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.098213 | 1.008 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.112448 | 0.949 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.069290 | 1.159 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.199694 | 0.700 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.272651 | 0.564 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.193296 | 0.714 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.253073 | 0.597 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.238421 | 0.623 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.253073 | 0.597 |
| R-HSA-8964046 | VLDL clearance | 0.076434 | 1.117 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.105358 | 0.977 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.022691 | 1.644 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.167193 | 0.777 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.224786 | 0.648 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.249097 | 0.604 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.093454 | 1.029 |
| R-HSA-9909396 | Circadian clock | 0.114626 | 0.941 |
| R-HSA-157579 | Telomere Maintenance | 0.212188 | 0.673 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.069059 | 1.161 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.091010 | 1.041 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.278424 | 0.555 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.153829 | 0.813 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.076434 | 1.117 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.091010 | 1.041 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.119482 | 0.923 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.140253 | 0.853 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.147068 | 0.832 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.173797 | 0.760 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.177114 | 0.752 |
| R-HSA-68882 | Mitotic Anaphase | 0.289531 | 0.538 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.098184 | 1.008 |
| R-HSA-68877 | Mitotic Prometaphase | 0.238307 | 0.623 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.056432 | 1.248 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.266832 | 0.574 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.096597 | 1.015 |
| R-HSA-2262752 | Cellular responses to stress | 0.037139 | 1.430 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.054134 | 1.267 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.061626 | 1.210 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.126460 | 0.898 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.133384 | 0.875 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.160538 | 0.794 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.167193 | 0.777 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.199694 | 0.700 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.266832 | 0.574 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.072718 | 1.138 |
| R-HSA-69239 | Synthesis of DNA | 0.244277 | 0.612 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.212339 | 0.673 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.044311 | 1.353 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 0.126460 | 0.898 |
| R-HSA-77387 | Insulin receptor recycling | 0.237037 | 0.625 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.255055 | 0.593 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.133554 | 0.874 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.206041 | 0.686 |
| R-HSA-1640170 | Cell Cycle | 0.224508 | 0.649 |
| R-HSA-525793 | Myogenesis | 0.027207 | 1.565 |
| R-HSA-392517 | Rap1 signalling | 0.173797 | 0.760 |
| R-HSA-198753 | ERK/MAPK targets | 0.186847 | 0.729 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.092561 | 1.034 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.226733 | 0.644 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.249097 | 0.604 |
| R-HSA-9930044 | Nuclear RNA decay | 0.266832 | 0.574 |
| R-HSA-3214847 | HATs acetylate histones | 0.217995 | 0.662 |
| R-HSA-2559583 | Cellular Senescence | 0.211278 | 0.675 |
| R-HSA-877300 | Interferon gamma signaling | 0.167383 | 0.776 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.206041 | 0.686 |
| R-HSA-70635 | Urea cycle | 0.224786 | 0.648 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.289834 | 0.538 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.186847 | 0.729 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.147068 | 0.832 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.186847 | 0.729 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.249097 | 0.604 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.073771 | 1.132 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.206041 | 0.686 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.133554 | 0.874 |
| R-HSA-3371556 | Cellular response to heat stress | 0.093454 | 1.029 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.223817 | 0.650 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.083751 | 1.077 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.181204 | 0.742 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.014719 | 1.832 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.167193 | 0.777 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.279489 | 0.554 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.180348 | 0.744 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.259488 | 0.586 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.144892 | 0.839 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.230936 | 0.637 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.017213 | 1.764 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.027207 | 1.565 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.272651 | 0.564 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.115822 | 0.936 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.046450 | 1.333 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.199694 | 0.700 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.206041 | 0.686 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.278424 | 0.555 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.149831 | 0.824 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.289834 | 0.538 |
| R-HSA-4839726 | Chromatin organization | 0.167237 | 0.777 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.034612 | 1.461 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.243091 | 0.614 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.260967 | 0.583 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.224786 | 0.648 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.136238 | 0.866 |
| R-HSA-163560 | Triglyceride catabolism | 0.289834 | 0.538 |
| R-HSA-9758941 | Gastrulation | 0.044983 | 1.347 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.038995 | 1.409 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.042661 | 1.370 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.278424 | 0.555 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.087300 | 1.059 |
| R-HSA-8964038 | LDL clearance | 0.199694 | 0.700 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.083000 | 1.081 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.284152 | 0.546 |
| R-HSA-354192 | Integrin signaling | 0.266832 | 0.574 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.128224 | 0.892 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.133495 | 0.875 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.247208 | 0.607 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.250140 | 0.602 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.260967 | 0.583 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.189138 | 0.723 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.230936 | 0.637 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.261877 | 0.582 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.270684 | 0.568 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.217995 | 0.662 |
| R-HSA-73886 | Chromosome Maintenance | 0.291218 | 0.536 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.291689 | 0.535 |
| R-HSA-418990 | Adherens junctions interactions | 0.293849 | 0.532 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.295472 | 0.529 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.295472 | 0.529 |
| R-HSA-69206 | G1/S Transition | 0.305846 | 0.514 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.306615 | 0.513 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.306615 | 0.513 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.306615 | 0.513 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.306615 | 0.513 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.306615 | 0.513 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.312120 | 0.506 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.312120 | 0.506 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.312120 | 0.506 |
| R-HSA-3371568 | Attenuation phase | 0.312120 | 0.506 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.312120 | 0.506 |
| R-HSA-5260271 | Diseases of Immune System | 0.312120 | 0.506 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.312120 | 0.506 |
| R-HSA-162906 | HIV Infection | 0.313325 | 0.504 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.314598 | 0.502 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.315493 | 0.501 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.317582 | 0.498 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.317582 | 0.498 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.324544 | 0.489 |
| R-HSA-8854214 | TBC/RABGAPs | 0.333712 | 0.477 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.333712 | 0.477 |
| R-HSA-8939211 | ESR-mediated signaling | 0.335008 | 0.475 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.339004 | 0.470 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.344255 | 0.463 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.346458 | 0.460 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.349464 | 0.457 |
| R-HSA-75153 | Apoptotic execution phase | 0.349464 | 0.457 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.352203 | 0.453 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.354632 | 0.450 |
| R-HSA-9609646 | HCMV Infection | 0.363152 | 0.440 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.363641 | 0.439 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.363641 | 0.439 |
| R-HSA-9766229 | Degradation of CDH1 | 0.364846 | 0.438 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.364846 | 0.438 |
| R-HSA-421270 | Cell-cell junction organization | 0.365311 | 0.437 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.366489 | 0.436 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.374899 | 0.426 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.375004 | 0.426 |
| R-HSA-162582 | Signal Transduction | 0.379624 | 0.421 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.379866 | 0.420 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.380654 | 0.419 |
| R-HSA-69242 | S Phase | 0.380654 | 0.419 |
| R-HSA-166520 | Signaling by NTRKs | 0.380654 | 0.419 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.384795 | 0.415 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.384795 | 0.415 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.384795 | 0.415 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.386284 | 0.413 |
| R-HSA-72649 | Translation initiation complex formation | 0.389684 | 0.409 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.389684 | 0.409 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.389684 | 0.409 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.394535 | 0.404 |
| R-HSA-69306 | DNA Replication | 0.394687 | 0.404 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.394687 | 0.404 |
| R-HSA-73887 | Death Receptor Signaling | 0.397477 | 0.401 |
| R-HSA-913531 | Interferon Signaling | 0.400591 | 0.397 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.401802 | 0.396 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.404122 | 0.393 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.404122 | 0.393 |
| R-HSA-162587 | HIV Life Cycle | 0.405810 | 0.392 |
| R-HSA-9711097 | Cellular response to starvation | 0.408576 | 0.389 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.408859 | 0.388 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.413559 | 0.383 |
| R-HSA-180786 | Extension of Telomeres | 0.413559 | 0.383 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.413559 | 0.383 |
| R-HSA-8979227 | Triglyceride metabolism | 0.413559 | 0.383 |
| R-HSA-186712 | Regulation of beta-cell development | 0.413559 | 0.383 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.418221 | 0.379 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.418221 | 0.379 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.418221 | 0.379 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.418221 | 0.379 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.418221 | 0.379 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.418221 | 0.379 |
| R-HSA-109581 | Apoptosis | 0.419577 | 0.377 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.422847 | 0.374 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.422847 | 0.374 |
| R-HSA-450294 | MAP kinase activation | 0.422847 | 0.374 |
| R-HSA-446728 | Cell junction organization | 0.423008 | 0.374 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.427436 | 0.369 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.427436 | 0.369 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.427436 | 0.369 |
| R-HSA-373755 | Semaphorin interactions | 0.431989 | 0.365 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.431989 | 0.365 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.431989 | 0.365 |
| R-HSA-8848021 | Signaling by PTK6 | 0.431989 | 0.365 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.445434 | 0.351 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.449845 | 0.347 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.449845 | 0.347 |
| R-HSA-9830369 | Kidney development | 0.449845 | 0.347 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.454221 | 0.343 |
| R-HSA-448424 | Interleukin-17 signaling | 0.462870 | 0.335 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.467143 | 0.331 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.467143 | 0.331 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.467143 | 0.331 |
| R-HSA-168255 | Influenza Infection | 0.467744 | 0.330 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.471383 | 0.327 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.471383 | 0.327 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.471383 | 0.327 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.475589 | 0.323 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.479762 | 0.319 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.483902 | 0.315 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.483902 | 0.315 |
| R-HSA-69275 | G2/M Transition | 0.485837 | 0.314 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.488010 | 0.312 |
| R-HSA-5689603 | UCH proteinases | 0.488010 | 0.312 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.490937 | 0.309 |
| R-HSA-216083 | Integrin cell surface interactions | 0.496127 | 0.304 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.498527 | 0.302 |
| R-HSA-9659379 | Sensory processing of sound | 0.500138 | 0.301 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.500138 | 0.301 |
| R-HSA-1500931 | Cell-Cell communication | 0.500943 | 0.300 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.504117 | 0.297 |
| R-HSA-6806834 | Signaling by MET | 0.504117 | 0.297 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.508848 | 0.293 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.511981 | 0.291 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.511981 | 0.291 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.515867 | 0.287 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.523546 | 0.281 |
| R-HSA-8953854 | Metabolism of RNA | 0.524090 | 0.281 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.527340 | 0.278 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.531104 | 0.275 |
| R-HSA-5357801 | Programmed Cell Death | 0.535388 | 0.271 |
| R-HSA-9663891 | Selective autophagy | 0.538544 | 0.269 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.545866 | 0.263 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.549484 | 0.260 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.553073 | 0.257 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.556634 | 0.254 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.556634 | 0.254 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.564138 | 0.249 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.567148 | 0.246 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.574020 | 0.241 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.577415 | 0.239 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.577415 | 0.239 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.580784 | 0.236 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.580784 | 0.236 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.580784 | 0.236 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.584125 | 0.233 |
| R-HSA-70171 | Glycolysis | 0.587441 | 0.231 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.589460 | 0.230 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.593993 | 0.226 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.600442 | 0.222 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.600442 | 0.222 |
| R-HSA-9833110 | RSV-host interactions | 0.603628 | 0.219 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.603628 | 0.219 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.603628 | 0.219 |
| R-HSA-211000 | Gene Silencing by RNA | 0.613036 | 0.213 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.616122 | 0.210 |
| R-HSA-199991 | Membrane Trafficking | 0.617969 | 0.209 |
| R-HSA-68886 | M Phase | 0.623981 | 0.205 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.628226 | 0.202 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.628226 | 0.202 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.628226 | 0.202 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.631192 | 0.200 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.634135 | 0.198 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.634135 | 0.198 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.642825 | 0.192 |
| R-HSA-5688426 | Deubiquitination | 0.644494 | 0.191 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.645675 | 0.190 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.645675 | 0.190 |
| R-HSA-70326 | Glucose metabolism | 0.648503 | 0.188 |
| R-HSA-5693538 | Homology Directed Repair | 0.651309 | 0.186 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.654093 | 0.184 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.654093 | 0.184 |
| R-HSA-68875 | Mitotic Prophase | 0.656854 | 0.183 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.659965 | 0.180 |
| R-HSA-422475 | Axon guidance | 0.662072 | 0.179 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.662312 | 0.179 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.662312 | 0.179 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.672970 | 0.172 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.672970 | 0.172 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.672970 | 0.172 |
| R-HSA-69481 | G2/M Checkpoints | 0.678173 | 0.169 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.689296 | 0.162 |
| R-HSA-9843745 | Adipogenesis | 0.690824 | 0.161 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.693294 | 0.159 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.705355 | 0.152 |
| R-HSA-9675108 | Nervous system development | 0.709931 | 0.149 |
| R-HSA-6807070 | PTEN Regulation | 0.712365 | 0.147 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.714665 | 0.146 |
| R-HSA-9664407 | Parasite infection | 0.714665 | 0.146 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.714665 | 0.146 |
| R-HSA-1632852 | Macroautophagy | 0.716946 | 0.145 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.716946 | 0.145 |
| R-HSA-74160 | Gene expression (Transcription) | 0.726198 | 0.139 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.742950 | 0.129 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.747047 | 0.127 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.747047 | 0.127 |
| R-HSA-1989781 | PPARA activates gene expression | 0.749072 | 0.125 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.749072 | 0.125 |
| R-HSA-9612973 | Autophagy | 0.751080 | 0.124 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.753072 | 0.123 |
| R-HSA-9610379 | HCMV Late Events | 0.753072 | 0.123 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.758955 | 0.120 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.758955 | 0.120 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.759408 | 0.120 |
| R-HSA-5619102 | SLC transporter disorders | 0.772145 | 0.112 |
| R-HSA-72306 | tRNA processing | 0.779358 | 0.108 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.781126 | 0.107 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.782879 | 0.106 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.786345 | 0.104 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.793533 | 0.100 |
| R-HSA-1266738 | Developmental Biology | 0.799294 | 0.097 |
| R-HSA-73894 | DNA Repair | 0.807441 | 0.093 |
| R-HSA-212436 | Generic Transcription Pathway | 0.812518 | 0.090 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.813560 | 0.090 |
| R-HSA-9824446 | Viral Infection Pathways | 0.814419 | 0.089 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.816647 | 0.088 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.818118 | 0.087 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.826701 | 0.083 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.826701 | 0.083 |
| R-HSA-72172 | mRNA Splicing | 0.833546 | 0.079 |
| R-HSA-9679506 | SARS-CoV Infections | 0.840084 | 0.076 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.863948 | 0.064 |
| R-HSA-72312 | rRNA processing | 0.867204 | 0.062 |
| R-HSA-157118 | Signaling by NOTCH | 0.875514 | 0.058 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.882360 | 0.054 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.883604 | 0.054 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.890617 | 0.050 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.894778 | 0.048 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.901384 | 0.045 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.905443 | 0.043 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.910654 | 0.041 |
| R-HSA-9658195 | Leishmania infection | 0.910654 | 0.041 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.911375 | 0.040 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.920237 | 0.036 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.929019 | 0.032 |
| R-HSA-5663205 | Infectious disease | 0.935804 | 0.029 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.936449 | 0.029 |
| R-HSA-8957322 | Metabolism of steroids | 0.936963 | 0.028 |
| R-HSA-1474244 | Extracellular matrix organization | 0.940447 | 0.027 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.940555 | 0.027 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.945541 | 0.024 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.947711 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.961315 | 0.017 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.963461 | 0.016 |
| R-HSA-1280218 | Adaptive Immune System | 0.973274 | 0.012 |
| R-HSA-72766 | Translation | 0.973428 | 0.012 |
| R-HSA-112316 | Neuronal System | 0.980692 | 0.008 |
| R-HSA-597592 | Post-translational protein modification | 0.983614 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.988278 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 0.993594 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994388 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 0.994704 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.995354 | 0.002 |
| R-HSA-1643685 | Disease | 0.997283 | 0.001 |
| R-HSA-168256 | Immune System | 0.998449 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.998590 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999387 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999732 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999952 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999970 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.841 | 0.735 | 1 | 0.850 |
HIPK2 |
0.834 | 0.686 | 1 | 0.868 |
CDK18 |
0.831 | 0.716 | 1 | 0.886 |
CDK19 |
0.826 | 0.688 | 1 | 0.896 |
P38G |
0.825 | 0.731 | 1 | 0.909 |
CDK17 |
0.824 | 0.718 | 1 | 0.901 |
CDK1 |
0.823 | 0.693 | 1 | 0.887 |
CDK8 |
0.822 | 0.688 | 1 | 0.879 |
P38D |
0.820 | 0.720 | 1 | 0.923 |
DYRK2 |
0.819 | 0.660 | 1 | 0.826 |
JNK2 |
0.819 | 0.730 | 1 | 0.898 |
ERK1 |
0.817 | 0.701 | 1 | 0.870 |
CDK3 |
0.816 | 0.613 | 1 | 0.902 |
CLK3 |
0.816 | 0.469 | 1 | 0.660 |
CDK16 |
0.816 | 0.679 | 1 | 0.893 |
CDK5 |
0.813 | 0.664 | 1 | 0.854 |
JNK3 |
0.813 | 0.726 | 1 | 0.884 |
P38B |
0.813 | 0.700 | 1 | 0.863 |
DYRK4 |
0.812 | 0.657 | 1 | 0.890 |
CDK7 |
0.812 | 0.660 | 1 | 0.877 |
HIPK1 |
0.812 | 0.621 | 1 | 0.806 |
CDK13 |
0.810 | 0.674 | 1 | 0.882 |
CDK12 |
0.809 | 0.676 | 1 | 0.893 |
HIPK4 |
0.807 | 0.460 | 1 | 0.663 |
CDK10 |
0.804 | 0.639 | 1 | 0.871 |
DYRK1B |
0.803 | 0.622 | 1 | 0.853 |
CDK14 |
0.802 | 0.666 | 1 | 0.862 |
P38A |
0.801 | 0.664 | 1 | 0.816 |
CDK9 |
0.801 | 0.657 | 1 | 0.876 |
SRPK1 |
0.799 | 0.337 | -3 | 0.764 |
ERK2 |
0.797 | 0.675 | 1 | 0.839 |
HIPK3 |
0.796 | 0.591 | 1 | 0.774 |
DYRK1A |
0.796 | 0.537 | 1 | 0.804 |
CLK2 |
0.796 | 0.385 | -3 | 0.768 |
NLK |
0.796 | 0.617 | 1 | 0.685 |
JNK1 |
0.795 | 0.651 | 1 | 0.897 |
MAK |
0.787 | 0.462 | -2 | 0.657 |
DYRK3 |
0.786 | 0.469 | 1 | 0.776 |
CDK6 |
0.786 | 0.629 | 1 | 0.870 |
CDK4 |
0.785 | 0.643 | 1 | 0.896 |
ERK5 |
0.785 | 0.348 | 1 | 0.586 |
SRPK2 |
0.784 | 0.267 | -3 | 0.692 |
CLK1 |
0.784 | 0.356 | -3 | 0.725 |
MTOR |
0.783 | 0.239 | 1 | 0.495 |
CLK4 |
0.781 | 0.327 | -3 | 0.755 |
COT |
0.781 | 0.032 | 2 | 0.865 |
ICK |
0.780 | 0.335 | -3 | 0.820 |
CDK2 |
0.780 | 0.483 | 1 | 0.805 |
SRPK3 |
0.779 | 0.261 | -3 | 0.727 |
CDKL5 |
0.778 | 0.185 | -3 | 0.783 |
PRP4 |
0.778 | 0.443 | -3 | 0.763 |
MOS |
0.776 | 0.131 | 1 | 0.414 |
CDKL1 |
0.775 | 0.168 | -3 | 0.787 |
CDC7 |
0.769 | -0.038 | 1 | 0.399 |
GRK1 |
0.769 | 0.131 | -2 | 0.732 |
MOK |
0.768 | 0.411 | 1 | 0.701 |
ATR |
0.768 | 0.043 | 1 | 0.436 |
PIM3 |
0.768 | 0.014 | -3 | 0.842 |
NDR2 |
0.766 | 0.017 | -3 | 0.844 |
PRKD1 |
0.765 | 0.033 | -3 | 0.818 |
IKKB |
0.764 | -0.060 | -2 | 0.604 |
PRPK |
0.764 | -0.043 | -1 | 0.755 |
TBK1 |
0.762 | -0.107 | 1 | 0.312 |
NUAK2 |
0.761 | 0.045 | -3 | 0.810 |
GRK7 |
0.761 | 0.108 | 1 | 0.371 |
SKMLCK |
0.760 | 0.007 | -2 | 0.698 |
RAF1 |
0.759 | -0.121 | 1 | 0.361 |
PKN3 |
0.759 | -0.012 | -3 | 0.804 |
PRKD2 |
0.758 | 0.025 | -3 | 0.769 |
CHAK2 |
0.758 | -0.023 | -1 | 0.738 |
BMPR1B |
0.758 | 0.039 | 1 | 0.356 |
IKKE |
0.757 | -0.121 | 1 | 0.315 |
IKKA |
0.757 | -0.034 | -2 | 0.613 |
CAMK1B |
0.757 | -0.019 | -3 | 0.810 |
PIM1 |
0.757 | 0.042 | -3 | 0.784 |
DSTYK |
0.756 | -0.089 | 2 | 0.889 |
RSK2 |
0.756 | 0.018 | -3 | 0.771 |
PDHK4 |
0.755 | -0.150 | 1 | 0.416 |
P90RSK |
0.755 | 0.020 | -3 | 0.778 |
ERK7 |
0.755 | 0.239 | 2 | 0.580 |
BMPR2 |
0.754 | -0.140 | -2 | 0.704 |
PKN2 |
0.754 | -0.024 | -3 | 0.794 |
NIK |
0.754 | -0.039 | -3 | 0.820 |
GSK3A |
0.754 | 0.215 | 4 | 0.451 |
GCN2 |
0.754 | -0.155 | 2 | 0.795 |
NDR1 |
0.754 | -0.040 | -3 | 0.818 |
MST4 |
0.754 | -0.034 | 2 | 0.839 |
TGFBR2 |
0.753 | -0.067 | -2 | 0.640 |
MLK1 |
0.753 | -0.062 | 2 | 0.832 |
CK1E |
0.753 | 0.107 | -3 | 0.518 |
GRK5 |
0.753 | -0.057 | -3 | 0.790 |
WNK1 |
0.753 | -0.060 | -2 | 0.714 |
NEK6 |
0.752 | -0.081 | -2 | 0.672 |
PKCD |
0.752 | -0.017 | 2 | 0.799 |
RIPK3 |
0.751 | -0.084 | 3 | 0.693 |
AURC |
0.751 | -0.008 | -2 | 0.467 |
MLK2 |
0.750 | -0.063 | 2 | 0.839 |
DAPK2 |
0.750 | -0.032 | -3 | 0.817 |
PKCB |
0.750 | 0.007 | 2 | 0.769 |
MARK4 |
0.750 | -0.054 | 4 | 0.775 |
MLK3 |
0.750 | -0.013 | 2 | 0.765 |
CAMLCK |
0.749 | -0.031 | -2 | 0.652 |
ULK2 |
0.749 | -0.199 | 2 | 0.792 |
MAPKAPK3 |
0.749 | -0.037 | -3 | 0.766 |
DLK |
0.749 | -0.099 | 1 | 0.377 |
RSK3 |
0.748 | -0.013 | -3 | 0.762 |
LATS1 |
0.747 | 0.025 | -3 | 0.861 |
AMPKA1 |
0.747 | -0.058 | -3 | 0.821 |
MAPKAPK2 |
0.747 | -0.012 | -3 | 0.747 |
CAMK2G |
0.746 | -0.102 | 2 | 0.766 |
CK1D |
0.746 | 0.130 | -3 | 0.469 |
PDHK1 |
0.746 | -0.203 | 1 | 0.392 |
CAMK2D |
0.746 | -0.078 | -3 | 0.791 |
NEK7 |
0.746 | -0.157 | -3 | 0.748 |
IRE1 |
0.745 | -0.057 | 1 | 0.315 |
PKACG |
0.745 | -0.038 | -2 | 0.538 |
HUNK |
0.745 | -0.104 | 2 | 0.803 |
AMPKA2 |
0.745 | -0.033 | -3 | 0.799 |
LATS2 |
0.745 | -0.051 | -5 | 0.669 |
RSK4 |
0.745 | 0.023 | -3 | 0.767 |
PKCA |
0.745 | -0.005 | 2 | 0.754 |
MASTL |
0.744 | -0.134 | -2 | 0.656 |
MPSK1 |
0.744 | 0.113 | 1 | 0.353 |
PKCG |
0.744 | -0.019 | 2 | 0.758 |
PHKG1 |
0.743 | -0.040 | -3 | 0.800 |
ATM |
0.743 | -0.034 | 1 | 0.412 |
PKCZ |
0.743 | -0.025 | 2 | 0.803 |
P70S6KB |
0.743 | -0.026 | -3 | 0.770 |
TSSK1 |
0.743 | -0.046 | -3 | 0.846 |
TGFBR1 |
0.743 | -0.030 | -2 | 0.685 |
ALK4 |
0.742 | -0.037 | -2 | 0.696 |
GRK4 |
0.742 | -0.043 | -2 | 0.726 |
YSK4 |
0.742 | -0.092 | 1 | 0.330 |
DNAPK |
0.742 | -0.012 | 1 | 0.412 |
PKACB |
0.742 | 0.002 | -2 | 0.475 |
TTBK2 |
0.742 | -0.082 | 2 | 0.700 |
GRK6 |
0.741 | -0.092 | 1 | 0.370 |
TSSK2 |
0.741 | -0.078 | -5 | 0.772 |
MNK1 |
0.741 | -0.028 | -2 | 0.596 |
PRKD3 |
0.741 | -0.003 | -3 | 0.726 |
BCKDK |
0.741 | -0.153 | -1 | 0.669 |
CAMK2A |
0.740 | -0.015 | 2 | 0.755 |
AKT2 |
0.740 | 0.034 | -3 | 0.690 |
SMG1 |
0.740 | -0.033 | 1 | 0.414 |
NUAK1 |
0.740 | -0.032 | -3 | 0.763 |
MNK2 |
0.740 | -0.060 | -2 | 0.588 |
NEK9 |
0.740 | -0.175 | 2 | 0.845 |
ULK1 |
0.740 | -0.186 | -3 | 0.718 |
QSK |
0.740 | -0.030 | 4 | 0.754 |
VRK2 |
0.739 | 0.032 | 1 | 0.446 |
CK1G1 |
0.739 | 0.053 | -3 | 0.525 |
ANKRD3 |
0.739 | -0.138 | 1 | 0.373 |
GRK2 |
0.739 | -0.007 | -2 | 0.626 |
NIM1 |
0.738 | -0.087 | 3 | 0.730 |
MSK2 |
0.738 | -0.034 | -3 | 0.742 |
MST3 |
0.738 | 0.021 | 2 | 0.853 |
CAMK2B |
0.738 | -0.052 | 2 | 0.731 |
MLK4 |
0.738 | -0.064 | 2 | 0.744 |
SGK3 |
0.737 | -0.005 | -3 | 0.752 |
ACVR2B |
0.737 | -0.059 | -2 | 0.648 |
TLK2 |
0.737 | -0.073 | 1 | 0.360 |
PAK1 |
0.737 | -0.068 | -2 | 0.605 |
PKCH |
0.737 | -0.042 | 2 | 0.752 |
PRKX |
0.737 | 0.020 | -3 | 0.706 |
RIPK1 |
0.737 | -0.162 | 1 | 0.327 |
PKR |
0.737 | -0.083 | 1 | 0.355 |
PASK |
0.736 | 0.053 | -3 | 0.843 |
MSK1 |
0.735 | -0.022 | -3 | 0.745 |
ACVR2A |
0.735 | -0.072 | -2 | 0.628 |
CHAK1 |
0.735 | -0.117 | 2 | 0.796 |
WNK3 |
0.735 | -0.227 | 1 | 0.345 |
MEKK3 |
0.735 | -0.021 | 1 | 0.351 |
SIK |
0.735 | -0.035 | -3 | 0.735 |
TAO3 |
0.734 | 0.011 | 1 | 0.371 |
MEK1 |
0.734 | -0.114 | 2 | 0.838 |
CAMK4 |
0.734 | -0.115 | -3 | 0.773 |
CK1A2 |
0.734 | 0.079 | -3 | 0.470 |
PAK3 |
0.734 | -0.098 | -2 | 0.595 |
PKG2 |
0.734 | -0.037 | -2 | 0.471 |
QIK |
0.734 | -0.095 | -3 | 0.771 |
BMPR1A |
0.734 | -0.019 | 1 | 0.350 |
ALK2 |
0.734 | -0.044 | -2 | 0.690 |
IRE2 |
0.734 | -0.084 | 2 | 0.764 |
AURB |
0.733 | -0.051 | -2 | 0.460 |
PINK1 |
0.733 | 0.080 | 1 | 0.509 |
PIM2 |
0.732 | 0.018 | -3 | 0.732 |
FAM20C |
0.732 | -0.017 | 2 | 0.581 |
MEKK2 |
0.732 | -0.042 | 2 | 0.824 |
MELK |
0.732 | -0.091 | -3 | 0.776 |
MYLK4 |
0.731 | -0.042 | -2 | 0.588 |
GSK3B |
0.731 | 0.067 | 4 | 0.447 |
DCAMKL1 |
0.731 | -0.038 | -3 | 0.780 |
ZAK |
0.730 | -0.099 | 1 | 0.346 |
MEK5 |
0.730 | -0.085 | 2 | 0.836 |
MARK3 |
0.730 | -0.054 | 4 | 0.704 |
GRK3 |
0.730 | 0.005 | -2 | 0.612 |
AKT1 |
0.729 | 0.005 | -3 | 0.709 |
DRAK1 |
0.729 | -0.111 | 1 | 0.343 |
BRSK1 |
0.729 | -0.062 | -3 | 0.771 |
PLK1 |
0.729 | -0.161 | -2 | 0.615 |
GCK |
0.728 | 0.012 | 1 | 0.355 |
CHK1 |
0.728 | -0.083 | -3 | 0.797 |
NEK2 |
0.728 | -0.152 | 2 | 0.832 |
NEK5 |
0.728 | -0.103 | 1 | 0.340 |
AURA |
0.728 | -0.054 | -2 | 0.444 |
PAK6 |
0.727 | -0.056 | -2 | 0.505 |
PAK2 |
0.727 | -0.095 | -2 | 0.586 |
BRSK2 |
0.727 | -0.091 | -3 | 0.771 |
NEK11 |
0.727 | -0.044 | 1 | 0.366 |
TLK1 |
0.726 | -0.093 | -2 | 0.700 |
GAK |
0.725 | 0.028 | 1 | 0.377 |
MAP3K15 |
0.725 | -0.027 | 1 | 0.346 |
MEKK1 |
0.725 | -0.135 | 1 | 0.357 |
MARK2 |
0.725 | -0.074 | 4 | 0.660 |
PKCT |
0.725 | -0.056 | 2 | 0.757 |
CAMK1G |
0.725 | -0.047 | -3 | 0.730 |
PLK4 |
0.724 | -0.123 | 2 | 0.607 |
PKCE |
0.724 | 0.003 | 2 | 0.747 |
PKACA |
0.722 | -0.018 | -2 | 0.424 |
MAPKAPK5 |
0.722 | -0.081 | -3 | 0.697 |
PERK |
0.722 | -0.144 | -2 | 0.670 |
BRAF |
0.722 | -0.141 | -4 | 0.683 |
PDK1 |
0.722 | -0.034 | 1 | 0.368 |
WNK4 |
0.722 | -0.127 | -2 | 0.705 |
IRAK4 |
0.722 | -0.134 | 1 | 0.306 |
HPK1 |
0.721 | -0.011 | 1 | 0.349 |
MEKK6 |
0.721 | -0.060 | 1 | 0.350 |
KHS1 |
0.720 | -0.003 | 1 | 0.337 |
SSTK |
0.720 | -0.072 | 4 | 0.748 |
PKCI |
0.720 | -0.046 | 2 | 0.771 |
LKB1 |
0.720 | -0.048 | -3 | 0.762 |
KHS2 |
0.719 | 0.022 | 1 | 0.353 |
SMMLCK |
0.719 | -0.057 | -3 | 0.773 |
MST2 |
0.719 | -0.078 | 1 | 0.349 |
SBK |
0.719 | 0.105 | -3 | 0.589 |
EEF2K |
0.718 | -0.037 | 3 | 0.782 |
TAO2 |
0.718 | -0.065 | 2 | 0.849 |
MARK1 |
0.718 | -0.101 | 4 | 0.728 |
DAPK3 |
0.718 | -0.033 | -3 | 0.784 |
TNIK |
0.717 | -0.027 | 3 | 0.831 |
CK1A |
0.717 | 0.100 | -3 | 0.395 |
PHKG2 |
0.717 | -0.100 | -3 | 0.749 |
SNRK |
0.717 | -0.167 | 2 | 0.688 |
PLK3 |
0.717 | -0.159 | 2 | 0.740 |
HGK |
0.717 | -0.053 | 3 | 0.832 |
DCAMKL2 |
0.717 | -0.074 | -3 | 0.778 |
AKT3 |
0.716 | 0.012 | -3 | 0.653 |
BUB1 |
0.716 | 0.028 | -5 | 0.734 |
SGK1 |
0.716 | 0.033 | -3 | 0.633 |
NEK8 |
0.716 | -0.131 | 2 | 0.834 |
PKN1 |
0.715 | -0.026 | -3 | 0.696 |
HRI |
0.715 | -0.207 | -2 | 0.662 |
CK2A2 |
0.715 | -0.033 | 1 | 0.318 |
MINK |
0.715 | -0.074 | 1 | 0.325 |
LRRK2 |
0.713 | -0.031 | 2 | 0.849 |
DAPK1 |
0.713 | -0.030 | -3 | 0.763 |
P70S6K |
0.712 | -0.047 | -3 | 0.686 |
CHK2 |
0.712 | -0.001 | -3 | 0.636 |
TAK1 |
0.712 | -0.090 | 1 | 0.355 |
CAMK1D |
0.712 | -0.042 | -3 | 0.676 |
HASPIN |
0.711 | 0.016 | -1 | 0.593 |
ROCK2 |
0.711 | -0.015 | -3 | 0.776 |
PAK5 |
0.710 | -0.080 | -2 | 0.453 |
TTBK1 |
0.709 | -0.136 | 2 | 0.613 |
NEK4 |
0.709 | -0.159 | 1 | 0.316 |
SLK |
0.709 | -0.067 | -2 | 0.532 |
CK2A1 |
0.708 | -0.035 | 1 | 0.310 |
LOK |
0.708 | -0.094 | -2 | 0.561 |
CAMKK1 |
0.707 | -0.209 | -2 | 0.580 |
VRK1 |
0.707 | -0.139 | 2 | 0.835 |
MRCKB |
0.707 | -0.028 | -3 | 0.716 |
MST1 |
0.707 | -0.113 | 1 | 0.329 |
PAK4 |
0.706 | -0.071 | -2 | 0.461 |
OSR1 |
0.706 | -0.027 | 2 | 0.816 |
PBK |
0.706 | -0.049 | 1 | 0.332 |
CAMKK2 |
0.706 | -0.177 | -2 | 0.570 |
NEK1 |
0.706 | -0.147 | 1 | 0.310 |
YSK1 |
0.705 | -0.093 | 2 | 0.826 |
CAMK1A |
0.705 | -0.026 | -3 | 0.655 |
DMPK1 |
0.704 | 0.006 | -3 | 0.740 |
MRCKA |
0.702 | -0.047 | -3 | 0.732 |
TTK |
0.702 | -0.043 | -2 | 0.655 |
PDHK3_TYR |
0.701 | 0.144 | 4 | 0.846 |
PLK2 |
0.700 | -0.081 | -3 | 0.689 |
IRAK1 |
0.698 | -0.242 | -1 | 0.615 |
PDHK4_TYR |
0.698 | 0.132 | 2 | 0.866 |
ROCK1 |
0.696 | -0.034 | -3 | 0.733 |
CRIK |
0.696 | 0.002 | -3 | 0.716 |
ASK1 |
0.696 | -0.095 | 1 | 0.345 |
STK33 |
0.694 | -0.142 | 2 | 0.604 |
TESK1_TYR |
0.693 | 0.037 | 3 | 0.835 |
ALPHAK3 |
0.693 | -0.039 | -1 | 0.655 |
PKG1 |
0.692 | -0.067 | -2 | 0.393 |
MYO3B |
0.692 | -0.073 | 2 | 0.836 |
RIPK2 |
0.690 | -0.226 | 1 | 0.318 |
PDHK1_TYR |
0.690 | 0.045 | -1 | 0.770 |
MAP2K4_TYR |
0.690 | 0.048 | -1 | 0.765 |
MYO3A |
0.690 | -0.076 | 1 | 0.328 |
MEK2 |
0.690 | -0.239 | 2 | 0.811 |
MAP2K6_TYR |
0.690 | 0.064 | -1 | 0.771 |
LIMK2_TYR |
0.690 | 0.069 | -3 | 0.829 |
PKMYT1_TYR |
0.690 | 0.087 | 3 | 0.803 |
NEK3 |
0.689 | -0.172 | 1 | 0.329 |
BIKE |
0.689 | -0.057 | 1 | 0.323 |
CK1G3 |
0.689 | 0.073 | -3 | 0.356 |
TAO1 |
0.688 | -0.101 | 1 | 0.321 |
BMPR2_TYR |
0.687 | 0.036 | -1 | 0.751 |
AAK1 |
0.686 | -0.012 | 1 | 0.291 |
YANK3 |
0.686 | -0.048 | 2 | 0.369 |
MAP2K7_TYR |
0.685 | -0.082 | 2 | 0.848 |
PINK1_TYR |
0.681 | -0.126 | 1 | 0.395 |
CSF1R |
0.678 | -0.055 | 3 | 0.750 |
RET |
0.678 | -0.133 | 1 | 0.364 |
LIMK1_TYR |
0.678 | -0.044 | 2 | 0.849 |
CK1G2 |
0.678 | 0.075 | -3 | 0.442 |
STLK3 |
0.678 | -0.154 | 1 | 0.324 |
TXK |
0.677 | -0.037 | 1 | 0.361 |
JAK2 |
0.676 | -0.102 | 1 | 0.373 |
ROS1 |
0.675 | -0.106 | 3 | 0.728 |
ABL2 |
0.675 | -0.071 | -1 | 0.669 |
FGR |
0.675 | -0.083 | 1 | 0.337 |
JAK3 |
0.674 | -0.098 | 1 | 0.367 |
MST1R |
0.674 | -0.114 | 3 | 0.769 |
YES1 |
0.674 | -0.072 | -1 | 0.744 |
EPHB4 |
0.673 | -0.114 | -1 | 0.703 |
TYK2 |
0.672 | -0.190 | 1 | 0.351 |
LCK |
0.672 | -0.047 | -1 | 0.710 |
JAK1 |
0.671 | -0.063 | 1 | 0.337 |
TNNI3K_TYR |
0.671 | -0.037 | 1 | 0.367 |
BLK |
0.671 | -0.032 | -1 | 0.718 |
TYRO3 |
0.671 | -0.154 | 3 | 0.755 |
ABL1 |
0.671 | -0.081 | -1 | 0.661 |
MET |
0.671 | -0.031 | 3 | 0.751 |
EPHA6 |
0.671 | -0.114 | -1 | 0.727 |
KIT |
0.669 | -0.082 | 3 | 0.750 |
TNK2 |
0.668 | -0.095 | 3 | 0.729 |
INSRR |
0.668 | -0.103 | 3 | 0.698 |
KDR |
0.668 | -0.068 | 3 | 0.702 |
NEK10_TYR |
0.666 | -0.134 | 1 | 0.314 |
HCK |
0.665 | -0.118 | -1 | 0.705 |
FER |
0.665 | -0.151 | 1 | 0.378 |
ITK |
0.665 | -0.114 | -1 | 0.659 |
FGFR2 |
0.665 | -0.082 | 3 | 0.741 |
FYN |
0.664 | -0.030 | -1 | 0.701 |
DDR1 |
0.664 | -0.175 | 4 | 0.762 |
TNK1 |
0.663 | -0.109 | 3 | 0.741 |
SRMS |
0.661 | -0.151 | 1 | 0.358 |
FLT1 |
0.661 | -0.072 | -1 | 0.686 |
SYK |
0.661 | 0.031 | -1 | 0.652 |
TEK |
0.661 | -0.074 | 3 | 0.691 |
EPHA4 |
0.660 | -0.102 | 2 | 0.736 |
BMX |
0.660 | -0.095 | -1 | 0.590 |
FGFR1 |
0.660 | -0.099 | 3 | 0.710 |
YANK2 |
0.659 | -0.050 | 2 | 0.390 |
EPHB1 |
0.659 | -0.170 | 1 | 0.367 |
FLT3 |
0.658 | -0.174 | 3 | 0.756 |
PDGFRB |
0.658 | -0.201 | 3 | 0.759 |
FGFR3 |
0.657 | -0.068 | 3 | 0.707 |
EPHB2 |
0.656 | -0.153 | -1 | 0.676 |
DDR2 |
0.656 | -0.061 | 3 | 0.680 |
EPHB3 |
0.656 | -0.173 | -1 | 0.683 |
TEC |
0.655 | -0.130 | -1 | 0.594 |
ZAP70 |
0.655 | 0.035 | -1 | 0.590 |
FRK |
0.655 | -0.125 | -1 | 0.697 |
MERTK |
0.655 | -0.160 | 3 | 0.732 |
ERBB2 |
0.654 | -0.126 | 1 | 0.342 |
WEE1_TYR |
0.654 | -0.097 | -1 | 0.607 |
EGFR |
0.653 | -0.082 | 1 | 0.307 |
AXL |
0.653 | -0.194 | 3 | 0.730 |
PDGFRA |
0.653 | -0.221 | 3 | 0.759 |
SRC |
0.652 | -0.078 | -1 | 0.698 |
PTK2 |
0.652 | -0.016 | -1 | 0.675 |
ALK |
0.652 | -0.166 | 3 | 0.670 |
LYN |
0.650 | -0.120 | 3 | 0.666 |
PTK2B |
0.650 | -0.104 | -1 | 0.645 |
INSR |
0.649 | -0.155 | 3 | 0.678 |
MATK |
0.648 | -0.102 | -1 | 0.597 |
EPHA7 |
0.648 | -0.153 | 2 | 0.745 |
BTK |
0.648 | -0.219 | -1 | 0.618 |
FGFR4 |
0.647 | -0.082 | -1 | 0.634 |
NTRK3 |
0.647 | -0.151 | -1 | 0.643 |
FLT4 |
0.646 | -0.166 | 3 | 0.689 |
NTRK1 |
0.645 | -0.227 | -1 | 0.680 |
EPHA1 |
0.645 | -0.193 | 3 | 0.731 |
LTK |
0.644 | -0.197 | 3 | 0.683 |
EPHA3 |
0.644 | -0.165 | 2 | 0.709 |
ERBB4 |
0.644 | -0.058 | 1 | 0.322 |
EPHA8 |
0.643 | -0.126 | -1 | 0.666 |
PTK6 |
0.643 | -0.230 | -1 | 0.593 |
NTRK2 |
0.642 | -0.227 | 3 | 0.704 |
EPHA5 |
0.640 | -0.154 | 2 | 0.724 |
CSK |
0.640 | -0.162 | 2 | 0.749 |
MUSK |
0.634 | -0.161 | 1 | 0.277 |
EPHA2 |
0.633 | -0.133 | -1 | 0.626 |
IGF1R |
0.633 | -0.144 | 3 | 0.615 |
FES |
0.615 | -0.163 | -1 | 0.567 |