Motif 261 (n=134)

Position-wise Probabilities
Download
uniprot genes site source protein function
A0A0A6YYC7 ZFP91-CNTF S101 ochoa E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog) Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256|ARBA:ARBA00054990}.
A1L390 PLEKHG3 S1046 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A6NJT0 UNCX S449 ochoa Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}.
B8ZZF3 None S322 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
O00148 DDX39A S43 ochoa ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}.
O00221 NFKBIE S183 ochoa NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}.
O14639 ABLIM1 S458 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O14733 MAP2K7 S61 ochoa Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.
O14827 RASGRF2 S854 ochoa Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
O43166 SIPA1L1 Y1133 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43439 CBFA2T2 S270 ochoa Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.
O43516 WIPF1 S244 ochoa WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
O60861 GAS7 S117 ochoa Growth arrest-specific protein 7 (GAS-7) May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
O75151 PHF2 S905 ochoa Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
O75385 ULK1 S781 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75385 ULK1 S783 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75626 PRDM1 S342 ochoa PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.
O75626 PRDM1 S355 ochoa PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.
O75665 OFD1 S850 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O94885 SASH1 S1031 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94929 ABLIM3 S379 ochoa Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
O95359 TACC2 S1796 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95402 MED26 S314 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
P11137 MAP2 S1540 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P15976 GATA1 S187 psp Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}.
P16144 ITGB4 S1521 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P23443 RPS6KB1 S447 ochoa|psp Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250|UniProtKB:P67999, ECO:0000250|UniProtKB:Q8BSK8, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:14673156, ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:15341740, ECO:0000269|PubMed:15899889, ECO:0000269|PubMed:16286006, ECO:0000269|PubMed:17052453, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:18952604, ECO:0000269|PubMed:19085255, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:28178239}.
P23588 EIF4B S504 ochoa|psp Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P24864 CCNE1 S387 ochoa|psp G1/S-specific cyclin-E1 Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
P27448 MARK3 S546 ochoa MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.
P27708 CAD T1906 ochoa Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}.
P27987 ITPKB S49 ochoa Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
P28290 ITPRID2 S759 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P28749 RBL1 S988 ochoa Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}.
P38398 BRCA1 S1503 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P42166 TMPO S442 ochoa Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42702 LIFR S1050 ochoa Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
P51825 AFF1 S212 ochoa|psp AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P53814 SMTN S357 ochoa Smoothelin Structural protein of the cytoskeleton.
P78559 MAP1A S1160 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q03164 KMT2A S3521 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q0JRZ9 FCHO2 S514 ochoa F-BAR domain only protein 2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Q12893 TMEM115 S320 ochoa Transmembrane protein 115 (Placental protein 6) (Protein PL6) May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}.
Q13094 LCP2 S344 ochoa Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}.
Q13207 TBX2 S342 ochoa T-box transcription factor TBX2 (T-box protein 2) Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.
Q13469 NFATC2 S814 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13838 DDX39B S44 ochoa Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.
Q14157 UBAP2L S416 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14669 TRIP12 S997 ochoa E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}.
Q14676 MDC1 S1570 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14764 MVP S873 ochoa Major vault protein (MVP) (Lung resistance-related protein) Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
Q14938 NFIX S268 ochoa Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q14980 NUMA1 S1868 ochoa Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.
Q15596 NCOA2 S493 ochoa|psp Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
Q15596 NCOA2 S499 ochoa|psp Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
Q15751 HERC1 S2723 ochoa Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
Q16512 PKN1 S579 ochoa Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.
Q16666 IFI16 S166 ochoa Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}.
Q3KQU3 MAP7D1 S460 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q5T200 ZC3H13 S378 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q641Q2 WASHC2A S996 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q66K74 MAP1S S646 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q674X7 KAZN S352 ochoa Kazrin Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}.
Q6PKG0 LARP1 S580 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q6UB99 ANKRD11 S1891 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6UXY1 BAIAP2L2 S231 ochoa BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.
Q6VY07 PACS1 S534 ochoa Phosphofurin acidic cluster sorting protein 1 (PACS-1) Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}.
Q71RC2 LARP4 S597 ochoa La-related protein 4 (La ribonucleoprotein domain family member 4) RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.
Q76L83 ASXL2 S530 ochoa Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}.
Q7RTP6 MICAL3 S1173 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z3B3 KANSL1 S994 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z3K3 POGZ S274 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z422 SZRD1 S74 ochoa SUZ RNA-binding domain-containing (SUZ domain-containing protein 1) (Putative MAPK-activating protein PM18/PM20/PM22) None
Q7Z6I6 ARHGAP30 S1043 ochoa Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}.
Q86UE8 TLK2 S117 ochoa Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}.
Q86WB0 ZC3HC1 S335 ochoa Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}.
Q86X51 EZHIP S465 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q86YN6 PPARGC1B S390 ochoa Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}.
Q8IVT2 MISP S400 ochoa|psp Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IWZ8 SUGP1 S344 ochoa SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) Plays a role in pre-mRNA splicing.
Q8IY63 AMOTL1 S906 ochoa Angiomotin-like protein 1 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}.
Q8IY92 SLX4 S1342 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IYB3 SRRM1 S420 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IZW8 TNS4 S248 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8NDV7 TNRC6A S1585 ochoa Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}.
Q8NFH5 NUP35 S135 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NHM5 KDM2B S848 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8TBP0 TBC1D16 S126 ochoa TBC1 domain family member 16 May act as a GTPase-activating protein for Rab family protein(s).
Q8WWM7 ATXN2L S604 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q92585 MAML1 S344 ochoa Mastermind-like protein 1 (Mam-1) Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Q92615 LARP4B S599 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q96AC1 FERMT2 S181 ochoa|psp Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
Q96JP5 ZFP91 S101 ochoa E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.
Q96RE7 NACC1 S151 ochoa Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}.
Q96RT1 ERBIN S1112 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q99081 TCF12 S392 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99501 GAS2L1 S492 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99590 SCAF11 S802 ochoa Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}.
Q9BV99 LRRC61 S188 ochoa Leucine-rich repeat-containing protein 61 None
Q9BY89 KIAA1671 S384 ochoa Uncharacterized protein KIAA1671 None
Q9BY89 KIAA1671 S1154 ochoa Uncharacterized protein KIAA1671 None
Q9C073 FAM117A S207 ochoa Protein FAM117A (C/EBP-induced protein) None
Q9GZU3 TMEM39B S53 ochoa Transmembrane protein 39B May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}.
Q9H0F6 SHARPIN S146 ochoa|psp Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9H7P6 MVB12B S207 ochoa Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Q9HB20 PLEKHA3 S250 ochoa Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.
Q9HCD6 TANC2 S1744 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9NQ75 CASS4 S249 ochoa Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.
Q9NQW6 ANLN S362 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NRF2 SH2B1 S102 ochoa SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}.
Q9NSY1 BMP2K S1141 ochoa BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.
Q9NYL2 MAP3K20 S733 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9NZN8 CNOT2 S126 ochoa CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Q9P206 NHSL3 S526 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P266 JCAD S696 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9UBP9 GULP1 S229 ochoa PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.
Q9UBS0 RPS6KB2 S423 ochoa|psp Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.
Q9UGJ0 PRKAG2 S71 ochoa 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}.
Q9UH99 SUN2 S38 ochoa SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.
Q9ULH1 ASAP1 S785 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9UQ35 SRRM2 S421 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S437 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S857 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S937 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1404 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1502 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1675 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2U8 LEMD3 S402 ochoa|psp Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y4E8 USP15 S242 ochoa Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}.
Q9Y6Q9 NCOA3 S569 ochoa Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Q9Y285 FARSA S199 Sugiyama Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) None
O75676 RPS6KA4 S700 Sugiyama Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}.
P08151 GLI1 S608 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
Q9NRA0 SPHK2 S393 Sugiyama Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Download
reactome_id name p -log10_p
R-HSA-9827857 Specification of primordial germ cells 0.000045 4.349
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.000114 3.944
R-HSA-3700989 Transcriptional Regulation by TP53 0.000089 4.053
R-HSA-6804754 Regulation of TP53 Expression 0.000579 3.238
R-HSA-74160 Gene expression (Transcription) 0.000755 3.122
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 0.001742 2.759
R-HSA-1474165 Reproduction 0.001789 2.748
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.002262 2.645
R-HSA-429947 Deadenylation of mRNA 0.002344 2.630
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.002565 2.591
R-HSA-73857 RNA Polymerase II Transcription 0.003149 2.502
R-HSA-2025928 Calcineurin activates NFAT 0.004977 2.303
R-HSA-1538133 G0 and Early G1 0.004532 2.344
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.004206 2.376
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.005567 2.254
R-HSA-8878171 Transcriptional regulation by RUNX1 0.005766 2.239
R-HSA-69205 G1/S-Specific Transcription 0.006365 2.196
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.007998 2.097
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.008583 2.066
R-HSA-212436 Generic Transcription Pathway 0.008499 2.071
R-HSA-165159 MTOR signalling 0.009581 2.019
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.010827 1.965
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.011996 1.921
R-HSA-418885 DCC mediated attractive signaling 0.011996 1.921
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.017117 1.767
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.017117 1.767
R-HSA-72187 mRNA 3'-end processing 0.015562 1.808
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.017190 1.765
R-HSA-9856651 MITF-M-dependent gene expression 0.015752 1.803
R-HSA-9730414 MITF-M-regulated melanocyte development 0.016180 1.791
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.017248 1.763
R-HSA-2980766 Nuclear Envelope Breakdown 0.019183 1.717
R-HSA-429914 Deadenylation-dependent mRNA decay 0.020752 1.683
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.020085 1.697
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.033943 1.469
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.033943 1.469
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.033943 1.469
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.033943 1.469
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.033943 1.469
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.033943 1.469
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.033943 1.469
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.033943 1.469
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.033943 1.469
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.033943 1.469
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.033943 1.469
R-HSA-9839394 TGFBR3 expression 0.029868 1.525
R-HSA-166208 mTORC1-mediated signalling 0.024777 1.606
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.030600 1.514
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.028656 1.543
R-HSA-73856 RNA Polymerase II Transcription Termination 0.022388 1.650
R-HSA-3214842 HDMs demethylate histones 0.029868 1.525
R-HSA-68875 Mitotic Prophase 0.029509 1.530
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.023167 1.635
R-HSA-1640170 Cell Cycle 0.024504 1.611
R-HSA-162582 Signal Transduction 0.026681 1.574
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.023167 1.635
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.024777 1.606
R-HSA-9843745 Adipogenesis 0.039295 1.406
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.050482 1.297
R-HSA-8849470 PTK6 Regulates Cell Cycle 0.066741 1.176
R-HSA-446107 Type I hemidesmosome assembly 0.090612 1.043
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.090612 1.043
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.113877 0.944
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.121500 0.915
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.129058 0.889
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.129058 0.889
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.136551 0.865
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.151346 0.820
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... 0.158649 0.800
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.065196 1.186
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.187241 0.728
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.194237 0.712
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.194237 0.712
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.194237 0.712
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.194237 0.712
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.194237 0.712
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.208051 0.682
R-HSA-8943723 Regulation of PTEN mRNA translation 0.221629 0.654
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.234976 0.629
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.254571 0.594
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.260992 0.583
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.267358 0.573
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.273669 0.563
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.273669 0.563
R-HSA-1855170 IPs transport between nucleus and cytosol 0.286129 0.543
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.286129 0.543
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.292280 0.534
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.304424 0.517
R-HSA-1989781 PPARA activates gene expression 0.063791 1.195
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.204493 0.689
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.065944 1.181
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.267358 0.573
R-HSA-72163 mRNA Splicing - Major Pathway 0.113710 0.944
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.201174 0.696
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.241564 0.617
R-HSA-140342 Apoptosis induced DNA fragmentation 0.106189 0.974
R-HSA-5620916 VxPx cargo-targeting to cilium 0.194237 0.712
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.298378 0.525
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.121598 0.915
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.121598 0.915
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.090612 1.043
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.098434 1.007
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.165889 0.780
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.046014 1.337
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.114535 0.941
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.129058 0.889
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.267358 0.573
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.121598 0.915
R-HSA-5693607 Processing of DNA double-strand break ends 0.179610 0.746
R-HSA-5693537 Resolution of D-Loop Structures 0.047312 1.325
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.058647 1.232
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.143980 0.842
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.045225 1.345
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.201174 0.696
R-HSA-1221632 Meiotic synapsis 0.098079 1.008
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.286129 0.543
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.316361 0.500
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.096387 1.016
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.101593 0.993
R-HSA-72172 mRNA Splicing 0.129781 0.887
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.248096 0.605
R-HSA-5578749 Transcriptional regulation by small RNAs 0.152260 0.817
R-HSA-5693606 DNA Double Strand Break Response 0.137461 0.862
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.137461 0.862
R-HSA-5673000 RAF activation 0.298378 0.525
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.241564 0.617
R-HSA-5693538 Homology Directed Repair 0.106909 0.971
R-HSA-5693532 DNA Double-Strand Break Repair 0.184467 0.734
R-HSA-2424491 DAP12 signaling 0.267358 0.573
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.066192 1.179
R-HSA-8875513 MET interacts with TNS proteins 0.042248 1.374
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.106189 0.974
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.129058 0.889
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.136551 0.865
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.136551 0.865
R-HSA-73980 RNA Polymerase III Transcription Termination 0.180185 0.744
R-HSA-350054 Notch-HLH transcription pathway 0.214869 0.668
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.260992 0.583
R-HSA-162588 Budding and maturation of HIV virion 0.273669 0.563
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.292280 0.534
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.298378 0.525
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.316361 0.500
R-HSA-2871796 FCERI mediated MAPK activation 0.290203 0.537
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.046090 1.336
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.213924 0.670
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.136551 0.865
R-HSA-500753 Pyrimidine biosynthesis 0.187241 0.728
R-HSA-1980145 Signaling by NOTCH2 0.298378 0.525
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.267358 0.573
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.143980 0.842
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.292280 0.534
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.322253 0.492
R-HSA-5632684 Hedgehog 'on' state 0.149275 0.826
R-HSA-1500620 Meiosis 0.191997 0.717
R-HSA-5357905 Regulation of TNFR1 signaling 0.079848 1.098
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.293383 0.533
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.054572 1.263
R-HSA-9706019 RHOBTB3 ATPase cycle 0.113877 0.944
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.201174 0.696
R-HSA-9615710 Late endosomal microautophagy 0.260992 0.583
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.267358 0.573
R-HSA-75893 TNF signaling 0.106220 0.974
R-HSA-5610787 Hedgehog 'off' state 0.072130 1.142
R-HSA-212165 Epigenetic regulation of gene expression 0.176315 0.754
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.084940 1.071
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.228331 0.641
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.228747 0.641
R-HSA-8934903 Receptor Mediated Mitophagy 0.106189 0.974
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.286129 0.543
R-HSA-180746 Nuclear import of Rev protein 0.298378 0.525
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.304424 0.517
R-HSA-5358351 Signaling by Hedgehog 0.150958 0.821
R-HSA-69206 G1/S Transition 0.121598 0.915
R-HSA-389948 Co-inhibition by PD-1 0.293479 0.532
R-HSA-5689603 UCH proteinases 0.164315 0.784
R-HSA-1852241 Organelle biogenesis and maintenance 0.172029 0.764
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.051589 1.287
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.180185 0.744
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.126791 0.897
R-HSA-9839373 Signaling by TGFBR3 0.079848 1.098
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.098434 1.007
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.158649 0.800
R-HSA-69473 G2/M DNA damage checkpoint 0.158266 0.801
R-HSA-9018519 Estrogen-dependent gene expression 0.146918 0.833
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.260992 0.583
R-HSA-9022692 Regulation of MECP2 expression and activity 0.286129 0.543
R-HSA-9613354 Lipophagy 0.098434 1.007
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.151346 0.820
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.173068 0.762
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.201174 0.696
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.241564 0.617
R-HSA-9675126 Diseases of mitotic cell cycle 0.279926 0.553
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.322253 0.492
R-HSA-1592230 Mitochondrial biogenesis 0.105125 0.978
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.179610 0.746
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.165889 0.780
R-HSA-9768759 Regulation of NPAS4 gene expression 0.173068 0.762
R-HSA-69236 G1 Phase 0.074856 1.126
R-HSA-69231 Cyclin D associated events in G1 0.074856 1.126
R-HSA-6783589 Interleukin-6 family signaling 0.228331 0.641
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.116005 0.936
R-HSA-73887 Death Receptor Signaling 0.186625 0.729
R-HSA-5689901 Metalloprotease DUBs 0.241564 0.617
R-HSA-2586552 Signaling by Leptin 0.106189 0.974
R-HSA-6794361 Neurexins and neuroligins 0.095407 1.020
R-HSA-2559585 Oncogene Induced Senescence 0.304424 0.517
R-HSA-69278 Cell Cycle, Mitotic 0.068860 1.162
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.136551 0.865
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.221629 0.654
R-HSA-8953854 Metabolism of RNA 0.320501 0.494
R-HSA-1170546 Prolactin receptor signaling 0.143980 0.842
R-HSA-8854214 TBC/RABGAPs 0.072400 1.140
R-HSA-525793 Myogenesis 0.241564 0.617
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.260992 0.583
R-HSA-8863795 Downregulation of ERBB2 signaling 0.267358 0.573
R-HSA-1483249 Inositol phosphate metabolism 0.290203 0.537
R-HSA-9612973 Autophagy 0.190960 0.719
R-HSA-2028269 Signaling by Hippo 0.173068 0.762
R-HSA-3214847 HATs acetylate histones 0.245611 0.610
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.195321 0.709
R-HSA-438064 Post NMDA receptor activation events 0.201360 0.696
R-HSA-175474 Assembly Of The HIV Virion 0.208051 0.682
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.041333 1.384
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.316361 0.500
R-HSA-5687128 MAPK6/MAPK4 signaling 0.191997 0.717
R-HSA-211000 Gene Silencing by RNA 0.274282 0.562
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.286129 0.543
R-HSA-114604 GPVI-mediated activation cascade 0.310418 0.508
R-HSA-159418 Recycling of bile acids and salts 0.286129 0.543
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.302912 0.519
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.060537 1.218
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.267358 0.573
R-HSA-3247509 Chromatin modifying enzymes 0.070142 1.154
R-HSA-1834941 STING mediated induction of host immune responses 0.187241 0.728
R-HSA-446728 Cell junction organization 0.257112 0.590
R-HSA-68886 M Phase 0.269271 0.570
R-HSA-446353 Cell-extracellular matrix interactions 0.151346 0.820
R-HSA-200425 Carnitine shuttle 0.221629 0.654
R-HSA-2559580 Oxidative Stress Induced Senescence 0.255162 0.593
R-HSA-6794362 Protein-protein interactions at synapses 0.191997 0.717
R-HSA-5205647 Mitophagy 0.298378 0.525
R-HSA-4839726 Chromatin organization 0.084658 1.072
R-HSA-9007101 Rab regulation of trafficking 0.312419 0.505
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.248096 0.605
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.286129 0.543
R-HSA-8875878 MET promotes cell motility 0.322253 0.492
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.310418 0.508
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.198233 0.703
R-HSA-9006936 Signaling by TGFB family members 0.069245 1.160
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.214869 0.668
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.255162 0.593
R-HSA-3000170 Syndecan interactions 0.221629 0.654
R-HSA-3000157 Laminin interactions 0.234976 0.629
R-HSA-5633007 Regulation of TP53 Activity 0.069245 1.160
R-HSA-8953750 Transcriptional Regulation by E2F6 0.060537 1.218
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.158649 0.800
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.221629 0.654
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.298378 0.525
R-HSA-2559583 Cellular Senescence 0.247001 0.607
R-HSA-1266738 Developmental Biology 0.179780 0.745
R-HSA-9663891 Selective autophagy 0.204493 0.689
R-HSA-5210891 Uptake and function of anthrax toxins 0.173068 0.762
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.239251 0.621
R-HSA-201556 Signaling by ALK 0.060537 1.218
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.236075 0.627
R-HSA-74158 RNA Polymerase III Transcription 0.310418 0.508
R-HSA-982772 Growth hormone receptor signaling 0.221629 0.654
R-HSA-373752 Netrin-1 signaling 0.074856 1.126
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.328094 0.484
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.328094 0.484
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.328094 0.484
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.328094 0.484
R-HSA-1500931 Cell-Cell communication 0.330205 0.481
R-HSA-68882 Mitotic Anaphase 0.333444 0.477
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.333886 0.476
R-HSA-202433 Generation of second messenger molecules 0.333886 0.476
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.333886 0.476
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.333886 0.476
R-HSA-177243 Interactions of Rev with host cellular proteins 0.333886 0.476
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.333886 0.476
R-HSA-162909 Host Interactions of HIV factors 0.334489 0.476
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.335797 0.474
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.339628 0.469
R-HSA-8853884 Transcriptional Regulation by VENTX 0.339628 0.469
R-HSA-3214841 PKMTs methylate histone lysines 0.339628 0.469
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.345321 0.462
R-HSA-5674135 MAP2K and MAPK activation 0.345321 0.462
R-HSA-9656223 Signaling by RAF1 mutants 0.345321 0.462
R-HSA-5675221 Negative regulation of MAPK pathway 0.345321 0.462
R-HSA-69481 G2/M Checkpoints 0.347012 0.460
R-HSA-379716 Cytosolic tRNA aminoacylation 0.350965 0.455
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.356560 0.448
R-HSA-162906 HIV Infection 0.359297 0.445
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.362108 0.441
R-HSA-2172127 DAP12 interactions 0.362108 0.441
R-HSA-9909396 Circadian clock 0.365649 0.437
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.367609 0.435
R-HSA-6783310 Fanconi Anemia Pathway 0.367609 0.435
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.373062 0.428
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.373062 0.428
R-HSA-9649948 Signaling downstream of RAS mutants 0.373062 0.428
R-HSA-6802949 Signaling by RAS mutants 0.373062 0.428
R-HSA-9675135 Diseases of DNA repair 0.373062 0.428
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.373062 0.428
R-HSA-75153 Apoptotic execution phase 0.373062 0.428
R-HSA-437239 Recycling pathway of L1 0.378469 0.422
R-HSA-8939211 ESR-mediated signaling 0.382684 0.417
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.383829 0.416
R-HSA-9031628 NGF-stimulated transcription 0.383829 0.416
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.389143 0.410
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.389143 0.410
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.389143 0.410
R-HSA-5683057 MAPK family signaling cascades 0.390757 0.408
R-HSA-1632852 Macroautophagy 0.396247 0.402
R-HSA-1169091 Activation of NF-kappaB in B cells 0.399636 0.398
R-HSA-912446 Meiotic recombination 0.399636 0.398
R-HSA-162599 Late Phase of HIV Life Cycle 0.402288 0.395
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.402288 0.395
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.404815 0.393
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.404815 0.393
R-HSA-5339562 Uptake and actions of bacterial toxins 0.404815 0.393
R-HSA-445355 Smooth Muscle Contraction 0.409950 0.387
R-HSA-8956320 Nucleotide biosynthesis 0.409950 0.387
R-HSA-72649 Translation initiation complex formation 0.415041 0.382
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.415041 0.382
R-HSA-9012852 Signaling by NOTCH3 0.420088 0.377
R-HSA-5688426 Deubiquitination 0.424269 0.372
R-HSA-72702 Ribosomal scanning and start codon recognition 0.425092 0.372
R-HSA-193648 NRAGE signals death through JNK 0.425092 0.372
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.425092 0.372
R-HSA-388841 Regulation of T cell activation by CD28 family 0.426554 0.370
R-HSA-69620 Cell Cycle Checkpoints 0.431114 0.365
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.434971 0.362
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.434971 0.362
R-HSA-191859 snRNP Assembly 0.439847 0.357
R-HSA-194441 Metabolism of non-coding RNA 0.439847 0.357
R-HSA-186712 Regulation of beta-cell development 0.439847 0.357
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.439847 0.357
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.444682 0.352
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.444682 0.352
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.444682 0.352
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.444682 0.352
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.444682 0.352
R-HSA-1227986 Signaling by ERBB2 0.444682 0.352
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.444682 0.352
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.444682 0.352
R-HSA-379724 tRNA Aminoacylation 0.444682 0.352
R-HSA-9610379 HCMV Late Events 0.446642 0.350
R-HSA-162587 HIV Life Cycle 0.446642 0.350
R-HSA-168325 Viral Messenger RNA Synthesis 0.449475 0.347
R-HSA-211976 Endogenous sterols 0.449475 0.347
R-HSA-9793380 Formation of paraxial mesoderm 0.449475 0.347
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.449475 0.347
R-HSA-450294 MAP kinase activation 0.449475 0.347
R-HSA-6784531 tRNA processing in the nucleus 0.454227 0.343
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.454227 0.343
R-HSA-9707616 Heme signaling 0.454227 0.343
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.454227 0.343
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.454227 0.343
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.458938 0.338
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.458938 0.338
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.458938 0.338
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.458938 0.338
R-HSA-8848021 Signaling by PTK6 0.458938 0.338
R-HSA-69615 G1/S DNA Damage Checkpoints 0.458938 0.338
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.468240 0.330
R-HSA-8854518 AURKA Activation by TPX2 0.472832 0.325
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.472832 0.325
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.477383 0.321
R-HSA-5621481 C-type lectin receptors (CLRs) 0.489122 0.311
R-HSA-69202 Cyclin E associated events during G1/S transition 0.490806 0.309
R-HSA-448424 Interleukin-17 signaling 0.490806 0.309
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.490806 0.309
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.490806 0.309
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.493749 0.306
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.494633 0.306
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.494633 0.306
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.495204 0.305
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.495204 0.305
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.499564 0.301
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.499564 0.301
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.500106 0.301
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.503887 0.298
R-HSA-69052 Switching of origins to a post-replicative state 0.503887 0.298
R-HSA-4086398 Ca2+ pathway 0.503887 0.298
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.503887 0.298
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.503887 0.298
R-HSA-9013694 Signaling by NOTCH4 0.508172 0.294
R-HSA-380287 Centrosome maturation 0.512421 0.290
R-HSA-1169408 ISG15 antiviral mechanism 0.512421 0.290
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.512421 0.290
R-HSA-1980143 Signaling by NOTCH1 0.516633 0.287
R-HSA-199991 Membrane Trafficking 0.520233 0.284
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.520810 0.283
R-HSA-416482 G alpha (12/13) signalling events 0.524950 0.280
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.529055 0.276
R-HSA-6806834 Signaling by MET 0.533125 0.273
R-HSA-5617833 Cilium Assembly 0.539934 0.268
R-HSA-9707564 Cytoprotection by HMOX1 0.545125 0.264
R-HSA-68877 Mitotic Prometaphase 0.547635 0.262
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.549057 0.260
R-HSA-6802957 Oncogenic MAPK signaling 0.552955 0.257
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.555247 0.256
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.556820 0.254
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.556820 0.254
R-HSA-390466 Chaperonin-mediated protein folding 0.564450 0.248
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.575651 0.240
R-HSA-1280218 Adaptive Immune System 0.577069 0.239
R-HSA-8986944 Transcriptional Regulation by MECP2 0.579321 0.237
R-HSA-391251 Protein folding 0.586566 0.232
R-HSA-1474290 Collagen formation 0.593687 0.226
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.596666 0.224
R-HSA-6807878 COPI-mediated anterograde transport 0.604142 0.219
R-HSA-8878159 Transcriptional regulation by RUNX3 0.607567 0.216
R-HSA-418990 Adherens junctions interactions 0.610585 0.214
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.610962 0.214
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.610962 0.214
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.610962 0.214
R-HSA-112316 Neuronal System 0.611946 0.213
R-HSA-192105 Synthesis of bile acids and bile salts 0.614329 0.212
R-HSA-193704 p75 NTR receptor-mediated signalling 0.614329 0.212
R-HSA-70171 Glycolysis 0.617666 0.209
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.624256 0.205
R-HSA-1483255 PI Metabolism 0.624256 0.205
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.630732 0.200
R-HSA-9705683 SARS-CoV-2-host interactions 0.632972 0.199
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.633929 0.198
R-HSA-5619507 Activation of HOX genes during differentiation 0.633929 0.198
R-HSA-9833110 RSV-host interactions 0.633929 0.198
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.637098 0.196
R-HSA-73894 DNA Repair 0.639663 0.194
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.642855 0.192
R-HSA-69239 Synthesis of DNA 0.643355 0.192
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.643355 0.192
R-HSA-9700206 Signaling by ALK in cancer 0.643355 0.192
R-HSA-9006931 Signaling by Nuclear Receptors 0.644933 0.190
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.646443 0.189
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.646443 0.189
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.646443 0.189
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.646443 0.189
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.649505 0.187
R-HSA-202403 TCR signaling 0.652540 0.185
R-HSA-194068 Bile acid and bile salt metabolism 0.652540 0.185
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.652540 0.185
R-HSA-166166 MyD88-independent TLR4 cascade 0.652540 0.185
R-HSA-157118 Signaling by NOTCH 0.658507 0.181
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.661490 0.179
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.670211 0.174
R-HSA-72613 Eukaryotic Translation Initiation 0.675901 0.170
R-HSA-72737 Cap-dependent Translation Initiation 0.675901 0.170
R-HSA-373760 L1CAM interactions 0.675901 0.170
R-HSA-9609646 HCMV Infection 0.678694 0.168
R-HSA-70326 Glucose metabolism 0.678709 0.168
R-HSA-421270 Cell-cell junction organization 0.680658 0.167
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.681493 0.167
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.684253 0.165
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.684253 0.165
R-HSA-8878166 Transcriptional regulation by RUNX2 0.684253 0.165
R-HSA-3371556 Cellular response to heat stress 0.689702 0.161
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.692392 0.160
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.692392 0.160
R-HSA-6809371 Formation of the cornified envelope 0.697701 0.156
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.710581 0.148
R-HSA-9711123 Cellular response to chemical stress 0.712588 0.147
R-HSA-5653656 Vesicle-mediated transport 0.725708 0.139
R-HSA-163685 Integration of energy metabolism 0.734728 0.134
R-HSA-3858494 Beta-catenin independent WNT signaling 0.734728 0.134
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.736854 0.133
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.737030 0.133
R-HSA-6807070 PTEN Regulation 0.741574 0.130
R-HSA-9664417 Leishmania phagocytosis 0.743817 0.129
R-HSA-9664407 Parasite infection 0.743817 0.129
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.743817 0.129
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.746040 0.127
R-HSA-5673001 RAF/MAP kinase cascade 0.748324 0.126
R-HSA-8856828 Clathrin-mediated endocytosis 0.752597 0.123
R-HSA-1257604 PIP3 activates AKT signaling 0.757815 0.120
R-HSA-5684996 MAPK1/MAPK3 signaling 0.759366 0.120
R-HSA-199977 ER to Golgi Anterograde Transport 0.761077 0.119
R-HSA-69242 S Phase 0.763152 0.117
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.763152 0.117
R-HSA-166520 Signaling by NTRKs 0.763152 0.117
R-HSA-9758941 Gastrulation 0.765209 0.116
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.769270 0.114
R-HSA-69306 DNA Replication 0.773261 0.112
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.775230 0.111
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.777183 0.109
R-HSA-109581 Apoptosis 0.790388 0.102
R-HSA-112315 Transmission across Chemical Synapses 0.798137 0.098
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.799342 0.097
R-HSA-5619102 SLC transporter disorders 0.799342 0.097
R-HSA-72306 tRNA processing 0.806230 0.094
R-HSA-5689880 Ub-specific processing proteases 0.811242 0.091
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.812884 0.090
R-HSA-168255 Influenza Infection 0.820883 0.086
R-HSA-9006925 Intracellular signaling by second messengers 0.822030 0.085
R-HSA-9694516 SARS-CoV-2 Infection 0.830178 0.081
R-HSA-69275 G2/M Transition 0.831515 0.080
R-HSA-453274 Mitotic G2-G2/M phases 0.834435 0.079
R-HSA-168898 Toll-like Receptor Cascades 0.838723 0.076
R-HSA-9609690 HCMV Early Events 0.845624 0.073
R-HSA-428157 Sphingolipid metabolism 0.852233 0.069
R-HSA-948021 Transport to the Golgi and subsequent modification 0.853520 0.069
R-HSA-5357801 Programmed Cell Death 0.858560 0.066
R-HSA-6805567 Keratinization 0.859793 0.066
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.866110 0.062
R-HSA-397014 Muscle contraction 0.866969 0.062
R-HSA-422475 Axon guidance 0.869996 0.060
R-HSA-8951664 Neddylation 0.877055 0.057
R-HSA-2262752 Cellular responses to stress 0.890400 0.050
R-HSA-15869 Metabolism of nucleotides 0.892205 0.050
R-HSA-9675108 Nervous system development 0.896082 0.048
R-HSA-5619115 Disorders of transmembrane transporters 0.902123 0.045
R-HSA-72766 Translation 0.902805 0.044
R-HSA-9734767 Developmental Cell Lineages 0.914954 0.039
R-HSA-76002 Platelet activation, signaling and aggregation 0.922791 0.035
R-HSA-211945 Phase I - Functionalization of compounds 0.925460 0.034
R-HSA-9824443 Parasitic Infection Pathways 0.927401 0.033
R-HSA-9658195 Leishmania infection 0.927401 0.033
R-HSA-1483257 Phospholipid metabolism 0.935816 0.029
R-HSA-195721 Signaling by WNT 0.937489 0.028
R-HSA-8953897 Cellular responses to stimuli 0.942065 0.026
R-HSA-8957322 Metabolism of steroids 0.950291 0.022
R-HSA-168249 Innate Immune System 0.951694 0.022
R-HSA-1474244 Extracellular matrix organization 0.953268 0.021
R-HSA-9679506 SARS-CoV Infections 0.961055 0.017
R-HSA-913531 Interferon Signaling 0.970748 0.013
R-HSA-109582 Hemostasis 0.972033 0.012
R-HSA-9824439 Bacterial Infection Pathways 0.972506 0.012
R-HSA-9824446 Viral Infection Pathways 0.973131 0.012
R-HSA-8978868 Fatty acid metabolism 0.976351 0.010
R-HSA-449147 Signaling by Interleukins 0.977014 0.010
R-HSA-168256 Immune System 0.977819 0.010
R-HSA-556833 Metabolism of lipids 0.979290 0.009
R-HSA-446203 Asparagine N-linked glycosylation 0.979298 0.009
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.984559 0.007
R-HSA-6798695 Neutrophil degranulation 0.984832 0.007
R-HSA-1280215 Cytokine Signaling in Immune system 0.986971 0.006
R-HSA-211859 Biological oxidations 0.991578 0.004
R-HSA-597592 Post-translational protein modification 0.992271 0.003
R-HSA-5663205 Infectious disease 0.993623 0.003
R-HSA-1643685 Disease 0.995772 0.002
R-HSA-392499 Metabolism of proteins 0.998483 0.001
R-HSA-388396 GPCR downstream signalling 0.999122 0.000
R-HSA-372790 Signaling by GPCR 0.999588 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.862 0.666 1 0.917
HIPK2HIPK2 0.845 0.641 1 0.922
CDK18CDK18 0.845 0.685 1 0.934
CDK1CDK1 0.844 0.669 1 0.919
CDK19CDK19 0.843 0.654 1 0.935
P38GP38G 0.842 0.706 1 0.928
P38DP38D 0.841 0.703 1 0.950
CDK8CDK8 0.841 0.655 1 0.926
ERK1ERK1 0.841 0.684 1 0.933
P38BP38B 0.840 0.702 1 0.921
JNK2JNK2 0.839 0.710 1 0.935
CDK17CDK17 0.838 0.683 1 0.922
JNK3JNK3 0.837 0.703 1 0.928
CDK3CDK3 0.836 0.604 1 0.929
DYRK2DYRK2 0.835 0.609 1 0.892
CDK7CDK7 0.834 0.640 1 0.933
CLK3CLK3 0.833 0.424 1 0.751
CDK13CDK13 0.832 0.649 1 0.935
CDK5CDK5 0.831 0.636 1 0.920
CDK12CDK12 0.830 0.652 1 0.936
P38AP38A 0.828 0.665 1 0.906
HIPK1HIPK1 0.828 0.573 1 0.888
DYRK4DYRK4 0.828 0.619 1 0.931
HIPK4HIPK4 0.827 0.421 1 0.774
ERK2ERK2 0.826 0.659 1 0.915
CDK16CDK16 0.826 0.643 1 0.928
NLKNLK 0.825 0.582 1 0.791
CDK14CDK14 0.823 0.644 1 0.922
CDK10CDK10 0.821 0.604 1 0.926
JNK1JNK1 0.820 0.632 1 0.923
ERK5ERK5 0.819 0.352 1 0.724
CDK9CDK9 0.818 0.615 1 0.931
DYRK1BDYRK1B 0.818 0.576 1 0.911
SRPK1SRPK1 0.817 0.271 -3 0.678
MTORMTOR 0.817 0.244 1 0.606
HIPK3HIPK3 0.816 0.546 1 0.874
DYRK1ADYRK1A 0.814 0.490 1 0.883
COTCOT 0.811 0.018 2 0.845
CDK6CDK6 0.810 0.616 1 0.931
CDK2CDK2 0.810 0.483 1 0.857
MAKMAK 0.809 0.458 -2 0.802
CLK2CLK2 0.807 0.339 -3 0.667
ICKICK 0.806 0.304 -3 0.762
MOSMOS 0.806 0.083 1 0.528
DYRK3DYRK3 0.805 0.437 1 0.858
CDK4CDK4 0.805 0.622 1 0.940
PRP4PRP4 0.805 0.394 -3 0.741
CLK4CLK4 0.805 0.302 -3 0.684
CDC7CDC7 0.802 -0.044 1 0.469
CDKL5CDKL5 0.801 0.134 -3 0.708
IKKBIKKB 0.801 -0.070 -2 0.707
SRPK2SRPK2 0.801 0.193 -3 0.592
CDKL1CDKL1 0.800 0.104 -3 0.722
SRPK3SRPK3 0.800 0.186 -3 0.660
CLK1CLK1 0.799 0.307 -3 0.649
GRK1GRK1 0.798 0.077 -2 0.777
ATRATR 0.798 -0.009 1 0.523
PRPKPRPK 0.797 -0.083 -1 0.849
SKMLCKSKMLCK 0.796 0.045 -2 0.848
PIM3PIM3 0.795 -0.026 -3 0.774
RAF1RAF1 0.795 -0.106 1 0.486
TBK1TBK1 0.794 -0.107 1 0.437
CK1ECK1E 0.792 0.171 -3 0.768
CK1DCK1D 0.792 0.207 -3 0.734
NDR2NDR2 0.792 -0.036 -3 0.786
GRK5GRK5 0.791 -0.040 -3 0.867
BMPR2BMPR2 0.791 -0.126 -2 0.820
IKKEIKKE 0.791 -0.120 1 0.433
PDHK4PDHK4 0.790 -0.186 1 0.544
PRKD1PRKD1 0.790 0.006 -3 0.746
IKKAIKKA 0.789 -0.047 -2 0.686
MLK1MLK1 0.788 -0.075 2 0.783
RIPK3RIPK3 0.788 -0.066 3 0.721
MST4MST4 0.787 -0.035 2 0.834
CAMK1BCAMK1B 0.786 -0.061 -3 0.778
AURCAURC 0.786 0.051 -2 0.673
GRK7GRK7 0.786 0.058 1 0.455
MOKMOK 0.786 0.378 1 0.815
BMPR1BBMPR1B 0.786 0.029 1 0.415
CHAK2CHAK2 0.785 -0.051 -1 0.848
CAMLCKCAMLCK 0.785 -0.002 -2 0.833
PRKD2PRKD2 0.785 0.000 -3 0.677
GCN2GCN2 0.785 -0.201 2 0.782
WNK1WNK1 0.784 -0.085 -2 0.859
CK1A2CK1A2 0.784 0.176 -3 0.730
NIKNIK 0.784 -0.076 -3 0.809
PDHK1PDHK1 0.783 -0.195 1 0.525
DSTYKDSTYK 0.783 -0.156 2 0.847
NDR1NDR1 0.783 -0.075 -3 0.758
RSK2RSK2 0.783 -0.022 -3 0.675
CAMK2GCAMK2G 0.782 -0.112 2 0.782
ERK7ERK7 0.781 0.212 2 0.516
PIM1PIM1 0.781 -0.006 -3 0.719
CK1G1CK1G1 0.781 0.122 -3 0.749
DAPK2DAPK2 0.781 -0.038 -3 0.785
MLK3MLK3 0.780 -0.020 2 0.701
MPSK1MPSK1 0.780 0.132 1 0.548
NEK6NEK6 0.780 -0.113 -2 0.770
GRK6GRK6 0.780 -0.061 1 0.453
TGFBR2TGFBR2 0.780 -0.098 -2 0.727
PKACGPKACG 0.779 -0.029 -2 0.724
IRE1IRE1 0.779 -0.069 1 0.470
PKN2PKN2 0.779 -0.068 -3 0.772
SMG1SMG1 0.779 -0.033 1 0.500
GRK4GRK4 0.779 -0.074 -2 0.773
NUAK2NUAK2 0.779 -0.054 -3 0.765
BCKDKBCKDK 0.778 -0.147 -1 0.800
DLKDLK 0.778 -0.120 1 0.476
ULK2ULK2 0.778 -0.230 2 0.770
MLK2MLK2 0.777 -0.083 2 0.796
PKN3PKN3 0.777 -0.093 -3 0.751
PAK1PAK1 0.777 -0.023 -2 0.810
P90RSKP90RSK 0.776 -0.042 -3 0.680
GSK3AGSK3A 0.776 0.175 4 0.409
NEK7NEK7 0.776 -0.203 -3 0.791
WNK3WNK3 0.776 -0.202 1 0.487
MASTLMASTL 0.776 -0.168 -2 0.761
PKACBPKACB 0.775 0.026 -2 0.676
AMPKA1AMPKA1 0.775 -0.094 -3 0.781
RSK3RSK3 0.774 -0.055 -3 0.672
MARK4MARK4 0.774 -0.098 4 0.834
RIPK1RIPK1 0.774 -0.166 1 0.458
VRK2VRK2 0.774 0.049 1 0.577
ANKRD3ANKRD3 0.774 -0.145 1 0.500
PAK3PAK3 0.774 -0.049 -2 0.799
PKCDPKCD 0.774 -0.052 2 0.749
TSSK2TSSK2 0.773 -0.071 -5 0.684
P70S6KBP70S6KB 0.773 -0.057 -3 0.701
ALK4ALK4 0.772 -0.052 -2 0.778
TTBK2TTBK2 0.772 -0.148 2 0.674
TSSK1TSSK1 0.771 -0.054 -3 0.793
LATS2LATS2 0.771 -0.089 -5 0.577
HUNKHUNK 0.771 -0.187 2 0.791
TLK2TLK2 0.771 -0.075 1 0.475
ATMATM 0.771 -0.074 1 0.465
PKRPKR 0.770 -0.076 1 0.503
MAPKAPK2MAPKAPK2 0.770 -0.050 -3 0.644
PINK1PINK1 0.770 0.081 1 0.662
MLK4MLK4 0.770 -0.064 2 0.696
AURBAURB 0.770 0.007 -2 0.667
MAPKAPK3MAPKAPK3 0.769 -0.096 -3 0.687
ACVR2BACVR2B 0.769 -0.050 -2 0.731
TGFBR1TGFBR1 0.769 -0.048 -2 0.744
FAM20CFAM20C 0.769 -0.019 2 0.586
YSK4YSK4 0.769 -0.123 1 0.452
GRK2GRK2 0.769 -0.031 -2 0.679
MST3MST3 0.769 0.012 2 0.809
PAK2PAK2 0.769 -0.050 -2 0.793
PKCAPKCA 0.768 -0.033 2 0.687
DNAPKDNAPK 0.768 -0.035 1 0.466
MNK2MNK2 0.768 -0.030 -2 0.767
PRKD3PRKD3 0.768 -0.045 -3 0.655
LATS1LATS1 0.768 -0.031 -3 0.778
ULK1ULK1 0.768 -0.223 -3 0.761
AMPKA2AMPKA2 0.768 -0.088 -3 0.741
MEK1MEK1 0.768 -0.106 2 0.823
AKT2AKT2 0.768 0.004 -3 0.601
PKG2PKG2 0.767 -0.009 -2 0.675
IRE2IRE2 0.767 -0.087 2 0.728
NEK9NEK9 0.767 -0.214 2 0.810
PKCBPKCB 0.767 -0.054 2 0.697
ACVR2AACVR2A 0.767 -0.065 -2 0.722
PRKXPRKX 0.767 0.014 -3 0.610
NIM1NIM1 0.766 -0.129 3 0.727
CAMK2DCAMK2D 0.766 -0.136 -3 0.753
MSK2MSK2 0.766 -0.064 -3 0.677
MYLK4MYLK4 0.765 -0.034 -2 0.773
PKCGPKCG 0.765 -0.065 2 0.692
MEKK3MEKK3 0.765 -0.081 1 0.471
MSK1MSK1 0.765 -0.026 -3 0.674
PAK6PAK6 0.765 -0.019 -2 0.736
RSK4RSK4 0.765 -0.030 -3 0.659
MNK1MNK1 0.764 -0.029 -2 0.768
AURAAURA 0.764 -0.004 -2 0.642
PHKG1PHKG1 0.763 -0.102 -3 0.751
CAMK4CAMK4 0.763 -0.143 -3 0.746
PIM2PIM2 0.763 -0.018 -3 0.651
QSKQSK 0.763 -0.069 4 0.819
PKCZPKCZ 0.763 -0.073 2 0.748
MEKK2MEKK2 0.763 -0.063 2 0.781
SGK3SGK3 0.763 -0.036 -3 0.686
ALK2ALK2 0.762 -0.065 -2 0.750
BMPR1ABMPR1A 0.762 -0.026 1 0.392
GAKGAK 0.761 0.036 1 0.549
MEK5MEK5 0.761 -0.129 2 0.809
GSK3BGSK3B 0.761 0.046 4 0.402
QIKQIK 0.761 -0.146 -3 0.755
TAO3TAO3 0.761 -0.034 1 0.492
CHAK1CHAK1 0.760 -0.151 2 0.763
PASKPASK 0.760 -0.027 -3 0.810
CAMK2ACAMK2A 0.759 -0.063 2 0.766
GRK3GRK3 0.759 -0.018 -2 0.643
NEK2NEK2 0.759 -0.162 2 0.788
LKB1LKB1 0.758 0.020 -3 0.783
MEKK1MEKK1 0.758 -0.132 1 0.486
PLK1PLK1 0.758 -0.174 -2 0.703
CK1ACK1A 0.758 0.150 -3 0.662
ZAKZAK 0.757 -0.130 1 0.440
CAMK2BCAMK2B 0.757 -0.101 2 0.752
MELKMELK 0.757 -0.130 -3 0.709
TLK1TLK1 0.756 -0.115 -2 0.758
WNK4WNK4 0.756 -0.142 -2 0.852
PKCHPKCH 0.756 -0.108 2 0.684
SSTKSSTK 0.755 -0.041 4 0.811
AKT1AKT1 0.755 -0.012 -3 0.619
NEK5NEK5 0.755 -0.121 1 0.492
GCKGCK 0.755 -0.017 1 0.485
BUB1BUB1 0.755 0.067 -5 0.664
SIKSIK 0.755 -0.099 -3 0.678
IRAK4IRAK4 0.754 -0.124 1 0.462
BRAFBRAF 0.754 -0.132 -4 0.789
MARK3MARK3 0.754 -0.073 4 0.774
PLK4PLK4 0.753 -0.145 2 0.630
PKACAPKACA 0.753 -0.010 -2 0.633
PERKPERK 0.753 -0.173 -2 0.761
NUAK1NUAK1 0.753 -0.127 -3 0.693
NEK11NEK11 0.752 -0.105 1 0.473
DCAMKL1DCAMKL1 0.752 -0.092 -3 0.703
HPK1HPK1 0.751 -0.014 1 0.474
PDK1PDK1 0.751 -0.071 1 0.483
TNIKTNIK 0.751 0.001 3 0.834
BRSK1BRSK1 0.751 -0.122 -3 0.708
PAK5PAK5 0.751 -0.036 -2 0.679
BRSK2BRSK2 0.751 -0.143 -3 0.726
HRIHRI 0.750 -0.205 -2 0.783
DRAK1DRAK1 0.750 -0.156 1 0.385
MARK2MARK2 0.750 -0.099 4 0.738
HGKHGK 0.750 -0.037 3 0.831
PLK3PLK3 0.749 -0.159 2 0.750
MINKMINK 0.749 -0.057 1 0.469
TAK1TAK1 0.749 -0.065 1 0.482
CK2A2CK2A2 0.749 -0.033 1 0.369
SMMLCKSMMLCK 0.749 -0.070 -3 0.731
SNRKSNRK 0.748 -0.199 2 0.682
MEKK6MEKK6 0.748 -0.088 1 0.491
TAO2TAO2 0.748 -0.088 2 0.810
MAP3K15MAP3K15 0.747 -0.069 1 0.453
KHS1KHS1 0.747 0.002 1 0.478
PKCTPKCT 0.747 -0.090 2 0.695
DAPK3DAPK3 0.747 -0.036 -3 0.723
CHK1CHK1 0.747 -0.159 -3 0.729
AKT3AKT3 0.747 -0.000 -3 0.546
KHS2KHS2 0.747 0.011 1 0.489
NEK8NEK8 0.746 -0.155 2 0.793
PBKPBK 0.746 -0.004 1 0.521
CAMK1GCAMK1G 0.746 -0.111 -3 0.665
PAK4PAK4 0.746 -0.027 -2 0.678
PKCEPKCE 0.745 -0.038 2 0.678
MAPKAPK5MAPKAPK5 0.745 -0.162 -3 0.623
MST2MST2 0.745 -0.098 1 0.476
PKCIPKCI 0.744 -0.073 2 0.716
TTBK1TTBK1 0.744 -0.167 2 0.597
P70S6KP70S6K 0.744 -0.086 -3 0.608
CAMKK1CAMKK1 0.744 -0.178 -2 0.695
MARK1MARK1 0.743 -0.132 4 0.790
EEF2KEEF2K 0.743 -0.066 3 0.796
LOKLOK 0.743 -0.072 -2 0.715
SGK1SGK1 0.742 -0.007 -3 0.527
CK2A1CK2A1 0.742 -0.035 1 0.350
LRRK2LRRK2 0.742 -0.073 2 0.822
SLKSLK 0.741 -0.069 -2 0.668
HASPINHASPIN 0.741 0.026 -1 0.718
PHKG2PHKG2 0.741 -0.139 -3 0.707
NEK4NEK4 0.741 -0.152 1 0.472
CAMKK2CAMKK2 0.740 -0.140 -2 0.693
DAPK1DAPK1 0.740 -0.045 -3 0.715
ROCK2ROCK2 0.740 -0.021 -3 0.711
SBKSBK 0.740 0.048 -3 0.469
DCAMKL2DCAMKL2 0.740 -0.122 -3 0.710
IRAK1IRAK1 0.738 -0.244 -1 0.785
MRCKBMRCKB 0.738 -0.032 -3 0.650
OSR1OSR1 0.737 -0.017 2 0.785
MST1MST1 0.736 -0.110 1 0.463
CK1G3CK1G3 0.736 0.132 -3 0.623
PDHK3_TYRPDHK3_TYR 0.735 0.156 4 0.875
CHK2CHK2 0.735 -0.065 -3 0.541
VRK1VRK1 0.734 -0.161 2 0.818
NEK1NEK1 0.734 -0.148 1 0.466
DMPK1DMPK1 0.733 0.004 -3 0.670
CAMK1DCAMK1D 0.733 -0.093 -3 0.591
MRCKAMRCKA 0.733 -0.054 -3 0.660
TTKTTK 0.733 -0.021 -2 0.733
YSK1YSK1 0.733 -0.113 2 0.784
PKN1PKN1 0.732 -0.088 -3 0.623
YANK3YANK3 0.731 -0.007 2 0.382
PDHK4_TYRPDHK4_TYR 0.731 0.129 2 0.870
STK33STK33 0.730 -0.138 2 0.592
PLK2PLK2 0.730 -0.089 -3 0.754
BIKEBIKE 0.730 -0.004 1 0.504
MAP2K6_TYRMAP2K6_TYR 0.728 0.094 -1 0.869
MAP2K4_TYRMAP2K4_TYR 0.728 0.074 -1 0.864
CRIKCRIK 0.727 -0.024 -3 0.616
MEK2MEK2 0.726 -0.217 2 0.799
TESK1_TYRTESK1_TYR 0.726 0.031 3 0.834
ALPHAK3ALPHAK3 0.726 -0.044 -1 0.760
MYO3BMYO3B 0.725 -0.056 2 0.798
PKG1PKG1 0.725 -0.054 -2 0.609
CAMK1ACAMK1A 0.725 -0.066 -3 0.566
PDHK1_TYRPDHK1_TYR 0.725 0.036 -1 0.869
ROCK1ROCK1 0.725 -0.039 -3 0.664
PKMYT1_TYRPKMYT1_TYR 0.725 0.065 3 0.806
ASK1ASK1 0.724 -0.089 1 0.443
BMPR2_TYRBMPR2_TYR 0.724 0.048 -1 0.869
RIPK2RIPK2 0.724 -0.239 1 0.414
MYO3AMYO3A 0.724 -0.067 1 0.470
LIMK2_TYRLIMK2_TYR 0.723 0.084 -3 0.808
AAK1AAK1 0.722 0.034 1 0.473
MAP2K7_TYRMAP2K7_TYR 0.721 -0.084 2 0.843
NEK3NEK3 0.719 -0.175 1 0.471
PINK1_TYRPINK1_TYR 0.716 -0.135 1 0.525
TAO1TAO1 0.715 -0.115 1 0.443
CK1G2CK1G2 0.715 0.098 -3 0.695
CSF1RCSF1R 0.714 -0.013 3 0.753
ABL2ABL2 0.714 -0.013 -1 0.802
RETRET 0.713 -0.103 1 0.493
ABL1ABL1 0.713 -0.012 -1 0.800
TXKTXK 0.712 -0.008 1 0.453
JAK2JAK2 0.712 -0.074 1 0.498
LCKLCK 0.711 0.002 -1 0.837
FGRFGR 0.711 -0.066 1 0.499
MST1RMST1R 0.711 -0.080 3 0.766
YES1YES1 0.711 -0.044 -1 0.842
LIMK1_TYRLIMK1_TYR 0.710 -0.082 2 0.832
BLKBLK 0.710 0.014 -1 0.828
STLK3STLK3 0.710 -0.141 1 0.428
EPHA6EPHA6 0.709 -0.065 -1 0.846
TYRO3TYRO3 0.709 -0.114 3 0.744
ROS1ROS1 0.709 -0.098 3 0.710
TYK2TYK2 0.708 -0.176 1 0.485
EPHB4EPHB4 0.708 -0.074 -1 0.816
KITKIT 0.707 -0.046 3 0.759
HCKHCK 0.707 -0.065 -1 0.836
TNK2TNK2 0.706 -0.060 3 0.723
KDRKDR 0.705 -0.030 3 0.723
FERFER 0.705 -0.137 1 0.496
METMET 0.705 -0.027 3 0.746
JAK3JAK3 0.704 -0.093 1 0.468
YANK2YANK2 0.704 -0.012 2 0.389
FGFR2FGFR2 0.704 -0.047 3 0.754
FYNFYN 0.703 -0.001 -1 0.823
DDR1DDR1 0.702 -0.151 4 0.802
NEK10_TYRNEK10_TYR 0.701 -0.108 1 0.447
ITKITK 0.701 -0.105 -1 0.819
FLT1FLT1 0.700 -0.042 -1 0.822
INSRRINSRR 0.700 -0.112 3 0.695
TNNI3K_TYRTNNI3K_TYR 0.700 -0.056 1 0.511
SRMSSRMS 0.699 -0.124 1 0.457
TNK1TNK1 0.699 -0.076 3 0.729
JAK1JAK1 0.699 -0.078 1 0.448
FLT3FLT3 0.698 -0.145 3 0.752
FGFR1FGFR1 0.697 -0.077 3 0.708
EPHA4EPHA4 0.697 -0.090 2 0.749
MERTKMERTK 0.696 -0.100 3 0.733
FGFR3FGFR3 0.696 -0.037 3 0.729
TEKTEK 0.696 -0.065 3 0.688
WEE1_TYRWEE1_TYR 0.695 -0.078 -1 0.760
PDGFRBPDGFRB 0.695 -0.188 3 0.755
BMXBMX 0.694 -0.079 -1 0.731
AXLAXL 0.694 -0.134 3 0.734
EPHB1EPHB1 0.693 -0.165 1 0.453
LYNLYN 0.692 -0.084 3 0.678
SRCSRC 0.692 -0.053 -1 0.810
TECTEC 0.692 -0.121 -1 0.750
EPHB3EPHB3 0.692 -0.147 -1 0.803
EPHB2EPHB2 0.692 -0.128 -1 0.791
ERBB2ERBB2 0.692 -0.121 1 0.435
SYKSYK 0.691 0.008 -1 0.772
FRKFRK 0.690 -0.100 -1 0.827
BTKBTK 0.690 -0.193 -1 0.796
PTK2PTK2 0.690 0.004 -1 0.811
MATKMATK 0.689 -0.070 -1 0.717
FGFR4FGFR4 0.688 -0.055 -1 0.747
PTK6PTK6 0.688 -0.184 -1 0.756
PDGFRAPDGFRA 0.687 -0.219 3 0.753
ALKALK 0.686 -0.159 3 0.650
EGFREGFR 0.686 -0.081 1 0.371
EPHA7EPHA7 0.686 -0.118 2 0.750
DDR2DDR2 0.685 -0.054 3 0.684
EPHA3EPHA3 0.684 -0.138 2 0.726
EPHA1EPHA1 0.684 -0.134 3 0.726
ZAP70ZAP70 0.683 0.029 -1 0.702
FLT4FLT4 0.683 -0.153 3 0.712
INSRINSR 0.683 -0.156 3 0.674
NTRK3NTRK3 0.683 -0.134 -1 0.759
PTK2BPTK2B 0.683 -0.098 -1 0.773
LTKLTK 0.683 -0.174 3 0.676
NTRK1NTRK1 0.682 -0.213 -1 0.810
NTRK2NTRK2 0.681 -0.212 3 0.719
ERBB4ERBB4 0.680 -0.041 1 0.375
EPHA8EPHA8 0.680 -0.101 -1 0.793
CSKCSK 0.680 -0.132 2 0.754
EPHA5EPHA5 0.677 -0.138 2 0.736
EPHA2EPHA2 0.670 -0.112 -1 0.763
IGF1RIGF1R 0.669 -0.137 3 0.617
MUSKMUSK 0.667 -0.158 1 0.369
FESFES 0.659 -0.135 -1 0.713