Motif 260 (n=251)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A3KN83 | SBNO1 | S823 | ochoa | Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) | Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250|UniProtKB:Q689Z5}. |
| A6NHT5 | HMX3 | S153 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| A6NKT7 | RGPD3 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8K855 | EFCAB7 | S212 | ochoa | EF-hand calcium-binding domain-containing protein 7 | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}. |
| I3L521 | None | S110 | ochoa | RNA-binding protein 7 (RNA-binding motif protein 7) | None |
| O00311 | CDC7 | S302 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00472 | ELL2 | S316 | ochoa | RNA polymerase II elongation factor ELL2 | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}. |
| O14639 | ABLIM1 | S458 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14646 | CHD1 | S1677 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14646 | CHD1 | S1683 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14646 | CHD1 | S1689 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14647 | CHD2 | S1801 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14647 | CHD2 | S1807 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14654 | IRS4 | S757 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S4883 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14715 | RGPD8 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14976 | GAK | S1096 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S842 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15042 | U2SURP | S485 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15085 | ARHGEF11 | S251 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15327 | INPP4B | S496 | ochoa | Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}. |
| O15344 | MID1 | S96 | ochoa|psp | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
| O43182 | ARHGAP6 | S673 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43303 | CCP110 | S516 | ochoa|psp | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O43314 | PPIP5K2 | S1172 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43516 | WIPF1 | S244 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O43520 | ATP8B1 | S1232 | ochoa | Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906, PubMed:25315773). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). {ECO:0000250|UniProtKB:Q148W0, ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20512993, ECO:0000269|PubMed:25239307, ECO:0000269|PubMed:27301931}. |
| O43521 | BCL2L11 | S104 | psp | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}. |
| O43683 | BUB1 | S655 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O43683 | BUB1 | S661 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60238 | BNIP3L | S97 | ochoa | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
| O60271 | SPAG9 | S251 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60583 | CCNT2 | S480 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O75362 | ZNF217 | S253 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75475 | PSIP1 | S177 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75665 | OFD1 | S669 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75925 | PIAS1 | S503 | ochoa | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O76021 | RSL1D1 | S427 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O95359 | TACC2 | S2256 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95425 | SVIL | S86 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95425 | SVIL | S920 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95490 | ADGRL2 | S1387 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| P04049 | RAF1 | S301 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P0DJD0 | RGPD1 | S1471 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1479 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10636 | MAPT | S739 | ochoa|psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P10721 | KIT | S943 | ochoa | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11137 | MAP2 | S1808 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11388 | TOP2A | S1393 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P15822 | HIVEP1 | S577 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P22736 | NR4A1 | S205 | ochoa | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P23511 | NFYA | S326 | ochoa|psp | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}. |
| P23588 | EIF4B | S504 | ochoa|psp | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P24928 | POLR2A | S1514 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P25054 | APC | S2772 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P31321 | PRKAR1B | S83 | ochoa | cAMP-dependent protein kinase type I-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}. |
| P38159 | RBMX | Y255 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P41250 | GARS1 | S335 | ochoa | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). {ECO:0000269|PubMed:17544401, ECO:0000269|PubMed:19710017, ECO:0000269|PubMed:24898252, ECO:0000269|PubMed:28675565}. |
| P42331 | ARHGAP25 | S407 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46013 | MKI67 | S713 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46020 | PHKA1 | S735 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
| P46063 | RECQL | S64 | ochoa | ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:19151156, ECO:0000269|PubMed:25831490, ECO:0000269|PubMed:35025765, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}. |
| P48681 | NES | S358 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S471 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48730 | CSNK1D | S356 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P48764 | SLC9A3 | S561 | ochoa | Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) | Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773). {ECO:0000250|UniProtKB:G3X939, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:24622516, ECO:0000269|PubMed:26358773, ECO:0000269|PubMed:35613257}. |
| P49790 | NUP153 | S209 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49790 | NUP153 | S240 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S2462 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49916 | LIG3 | S242 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P49918 | CDKN1C | S297 | ochoa | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| P50747 | HLCS | S147 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P50750 | CDK9 | S353 | ochoa|psp | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:16427012, PubMed:20930849, PubMed:28426094, PubMed:30134174). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE (PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:16427012, PubMed:20081228, PubMed:20980437, PubMed:21127351, PubMed:9857195). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:10912001, PubMed:11112772, PubMed:9857195). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity (PubMed:29335245). {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11145967, ECO:0000269|PubMed:11575923, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:11884399, ECO:0000269|PubMed:12037670, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15564463, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:17956865, ECO:0000269|PubMed:18362169, ECO:0000269|PubMed:19575011, ECO:0000269|PubMed:19844166, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:20930849, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:9857195}. |
| P50851 | LRBA | S1767 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51003 | PAPOLA | S660 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P53814 | SMTN | S529 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54132 | BLM | S1296 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54198 | HIRA | S549 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P55265 | ADAR | S614 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P98172 | EFNB1 | S287 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| Q00587 | CDC42EP1 | S77 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q02446 | SP4 | S46 | ochoa | Transcription factor Sp4 (SPR-1) | Binds to GT and GC boxes promoters elements. Probable transcriptional activator. |
| Q03164 | KMT2A | S197 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q08AD1 | CAMSAP2 | S1319 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S216 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13207 | TBX2 | S342 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13469 | NFATC2 | S236 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13469 | NFATC2 | S814 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13492 | PICALM | S359 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13523 | PRP4K | S387 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13613 | MTMR1 | S49 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q13796 | SHROOM2 | S195 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14135 | VGLL4 | S149 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14157 | UBAP2L | S416 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14162 | SCARF1 | S611 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14181 | POLA2 | S147 | ochoa | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}. |
| Q14289 | PTK2B | S758 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14524 | SCN5A | S577 | ochoa | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q14669 | TRIP12 | S1036 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14789 | GOLGB1 | S3016 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14938 | NFIX | S250 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q14980 | NUMA1 | S1862 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15003 | NCAPH | S87 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15036 | SNX17 | S415 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15723 | ELF2 | S191 | ochoa | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation. |
| Q15723 | ELF2 | S430 | ochoa | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation. |
| Q16875 | PFKFB3 | S467 | ochoa|psp | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:10077634, ECO:0000269|PubMed:17499765, ECO:0000305|PubMed:16316985}. |
| Q1ED39 | KNOP1 | S48 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q2KHR3 | QSER1 | S1211 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q3KQU3 | MAP7D1 | S280 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4L180 | FILIP1L | S1019 | ochoa | Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}. |
| Q562F6 | SGO2 | S1144 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5JTD0 | TJAP1 | S531 | ochoa | Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) | Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}. |
| Q5SQI0 | ATAT1 | S276 | ochoa | Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}. |
| Q5T1M5 | FKBP15 | S326 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T7N3 | KANK4 | S636 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5TCZ1 | SH3PXD2A | S644 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VT52 | RPRD2 | S485 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S1043 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VVW2 | GARNL3 | S432 | ochoa | GTPase-activating Rap/Ran-GAP domain-like protein 3 | None |
| Q5VWQ8 | DAB2IP | S978 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q6FI81 | CIAPIN1 | S183 | ochoa | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q6KC79 | NIPBL | S280 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6KC79 | NIPBL | S2658 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6N021 | TET2 | S21 | ochoa | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485, ECO:0000269|PubMed:32518946}. |
| Q6P4F7 | ARHGAP11A | S868 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PJI9 | WDR59 | S822 | ochoa | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}. |
| Q6PJT7 | ZC3H14 | S409 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6PL18 | ATAD2 | S342 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6VY07 | PACS1 | S534 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6WKZ4 | RAB11FIP1 | S345 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZRV2 | FAM83H | S850 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZSR9 | None | S300 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZT07 | TBC1D9 | S434 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6ZW31 | SYDE1 | S66 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q7LBC6 | KDM3B | S779 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z3J3 | RGPD4 | S1487 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z401 | DENND4A | S1256 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z4H7 | HAUS6 | S914 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z5J4 | RAI1 | S345 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z628 | NET1 | S106 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6B7 | SRGAP1 | S835 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86UU0 | BCL9L | S987 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86V15 | CASZ1 | S987 | ochoa | Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693) | Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}. |
| Q86WB0 | ZC3HC1 | S62 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q8IV31 | TMEM139 | S155 | ochoa | Transmembrane protein 139 | May be involved in cellular trafficking of proteins such as SLC4A1. {ECO:0000305|PubMed:26049106}. |
| Q8IVH2 | FOXP4 | S448 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
| Q8IWS0 | PHF6 | S199 | ochoa | PHD finger protein 6 (PHD-like zinc finger protein) | Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269|PubMed:23229552}. |
| Q8IY63 | AMOTL1 | S906 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IYB1 | MB21D2 | S439 | ochoa | Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2) | Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. {ECO:0000305|PubMed:34261127}. |
| Q8IYB3 | SRRM1 | S781 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N302 | AGGF1 | S344 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N4C8 | MINK1 | S778 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N6H7 | ARFGAP2 | S146 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NEY1 | NAV1 | S312 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHV4 | NEDD1 | S411 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TB45 | DEPTOR | S244 | ochoa|psp | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TDY2 | RB1CC1 | S653 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TED9 | AFAP1L1 | S149 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TEK3 | DOT1L | S1065 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TER5 | ARHGEF40 | S1480 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8TEW0 | PARD3 | S809 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WVM8 | SCFD1 | S303 | ochoa|psp | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WWI1 | LMO7 | S1026 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | S1516 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92619 | ARHGAP45 | S99 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92625 | ANKS1A | S634 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92994 | BRF1 | S553 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q969V6 | MRTFA | S139 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96A73 | KIAA1191 | S183 | ochoa | Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) | Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. |
| Q96BD0 | SLCO4A1 | S40 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96E39 | RBMXL1 | Y255 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96K37 | SLC35E1 | S363 | ochoa | Solute carrier family 35 member E1 | Putative transporter. {ECO:0000250}. |
| Q96NU1 | SAMD11 | S646 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96NY9 | MUS81 | S101 | ochoa | Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog) | Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:11741546, PubMed:12374758, PubMed:12686547, PubMed:12721304, PubMed:24371268, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24371268, PubMed:24733841, PubMed:35290797). MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:24813886). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork (PubMed:24813886). MUS81-EME2 could also function in telomere maintenance (PubMed:24813886). MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (PubMed:11741546, PubMed:12374758, PubMed:14617801, PubMed:15805243, PubMed:24813886). {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:24371268, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}. |
| Q96PC5 | MIA2 | S1204 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96QT4 | TRPM7 | S1396 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RT1 | ERBIN | S832 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96SK2 | TMEM209 | S228 | ochoa | Transmembrane protein 209 | Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}. |
| Q96T58 | SPEN | S2126 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99666 | RGPD5 | S1486 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99700 | ATXN2 | S684 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BRD0 | BUD13 | S391 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BW04 | SARG | S502 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BW04 | SARG | S519 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BWT3 | PAPOLG | S29 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BX63 | BRIP1 | S128 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BYB0 | SHANK3 | S1133 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C073 | FAM117A | S207 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9H1I8 | ASCC2 | S713 | ochoa | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q9H2D6 | TRIOBP | S1955 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H334 | FOXP1 | S621 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H4G0 | EPB41L1 | S546 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H4X1 | RGCC | S97 | ochoa | Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) | Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}. |
| Q9H5I1 | SUV39H2 | S388 | ochoa | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126}. |
| Q9H706 | GAREM1 | S622 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H7N4 | SCAF1 | S725 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H972 | C14orf93 | S285 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9HAU0 | PLEKHA5 | S1098 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HC35 | EML4 | S144 | ochoa|psp | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCC9 | ZFYVE28 | S384 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9HCD6 | TANC2 | S1744 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NQS7 | INCENP | S312 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQT8 | KIF13B | S1438 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQX3 | GPHN | S270 | ochoa|psp | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NRA8 | EIF4ENIF1 | S752 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NS37 | CREBZF | S22 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Q9NS91 | RAD18 | S164 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NSI2 | SLX9 | S209 | ochoa | Ribosome biogenesis protein SLX9 homolog | May be involved in ribosome biogenesis. {ECO:0000250|UniProtKB:P53251}. |
| Q9NVF7 | FBXO28 | S344 | ochoa | F-box only protein 28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000250}. |
| Q9NWS9 | ZNF446 | S362 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NXR5 | ANKRD10 | S353 | ochoa | Ankyrin repeat domain-containing protein 10 | None |
| Q9NYB0 | TERF2IP | S36 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9NYF8 | BCLAF1 | S531 | ochoa|psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NYI0 | PSD3 | S1020 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NYL2 | MAP3K20 | S599 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYL2 | MAP3K20 | S733 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NZN5 | ARHGEF12 | S28 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9NZN5 | ARHGEF12 | S309 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P1Y5 | CAMSAP3 | S1080 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P2D0 | IBTK | S1045 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2Q2 | FRMD4A | S657 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UBW5 | BIN2 | S375 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UDT6 | CLIP2 | S54 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UER7 | DAXX | S618 | ochoa | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UEY8 | ADD3 | S461 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UGU0 | TCF20 | S871 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UGU0 | TCF20 | S1053 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UH99 | SUN2 | S38 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UHR4 | BAIAP2L1 | S261 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UJV3 | MID2 | S116 | ochoa | Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). {ECO:0000269|PubMed:35266954, ECO:0000303|PubMed:24115387}. |
| Q9UKV3 | ACIN1 | S490 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULD5 | ZNF777 | S502 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9ULK2 | ATXN7L1 | S843 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9ULM3 | YEATS2 | S124 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UN79 | SOX13 | S83 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPN4 | CEP131 | S150 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPQ0 | LIMCH1 | S756 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPT8 | ZC3H4 | S1275 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9Y261 | FOXA2 | S309 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2H0 | DLGAP4 | S384 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y426 | C2CD2 | S441 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y4B5 | MTCL1 | S1752 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F1 | FARP1 | S433 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4F1 | FARP1 | S878 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S425 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y520 | PRRC2C | S2686 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6J9 | TAF6L | S501 | ochoa | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}. |
| Q9Y6Q9 | NCOA3 | S569 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9H9S0 | NANOG | S71 | PSP | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9UPT8 | ZC3H4 | S146 | Sugiyama | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-68877 | Mitotic Prometaphase | 0.000014 | 4.850 |
| R-HSA-1640170 | Cell Cycle | 0.000080 | 4.097 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.000520 | 3.284 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000783 | 3.106 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.001241 | 2.906 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.001241 | 2.906 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.001230 | 2.910 |
| R-HSA-68886 | M Phase | 0.001159 | 2.936 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.001528 | 2.816 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.002392 | 2.621 |
| R-HSA-380287 | Centrosome maturation | 0.002696 | 2.569 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.004517 | 2.345 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.004431 | 2.353 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.004369 | 2.360 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.004117 | 2.385 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.005161 | 2.287 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.005353 | 2.271 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.005220 | 2.282 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.006266 | 2.203 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.006287 | 2.202 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.006696 | 2.174 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.008466 | 2.072 |
| R-HSA-1474165 | Reproduction | 0.011052 | 1.957 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.011366 | 1.944 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.016261 | 1.789 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.016261 | 1.789 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.016261 | 1.789 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.015585 | 1.807 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.016943 | 1.771 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.018982 | 1.722 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.018982 | 1.722 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.020215 | 1.694 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.020215 | 1.694 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.019674 | 1.706 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.025278 | 1.597 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.032259 | 1.491 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.032259 | 1.491 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.032259 | 1.491 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.032259 | 1.491 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.032259 | 1.491 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.047998 | 1.319 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.047998 | 1.319 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.047998 | 1.319 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 0.047998 | 1.319 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.047998 | 1.319 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.063481 | 1.197 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.063481 | 1.197 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 0.063481 | 1.197 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.063481 | 1.197 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.063481 | 1.197 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.063481 | 1.197 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.063481 | 1.197 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.063481 | 1.197 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.063481 | 1.197 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.063481 | 1.197 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.063481 | 1.197 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.063481 | 1.197 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.078714 | 1.104 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.078714 | 1.104 |
| R-HSA-8941237 | Invadopodia formation | 0.078714 | 1.104 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.078714 | 1.104 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.108443 | 0.965 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.032243 | 1.492 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.137216 | 0.863 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.151254 | 0.820 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.151254 | 0.820 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.151254 | 0.820 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.151254 | 0.820 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 0.165064 | 0.782 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.165064 | 0.782 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.165064 | 0.782 |
| R-HSA-3928664 | Ephrin signaling | 0.055397 | 1.257 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.055397 | 1.257 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.059689 | 1.224 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.178651 | 0.748 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.064091 | 1.193 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.064091 | 1.193 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.064091 | 1.193 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.064091 | 1.193 |
| R-HSA-68952 | DNA replication initiation | 0.192017 | 0.717 |
| R-HSA-4839744 | Signaling by APC mutants | 0.205166 | 0.688 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.205166 | 0.688 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.205166 | 0.688 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.205166 | 0.688 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.036570 | 1.437 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.218102 | 0.661 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.218102 | 0.661 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.218102 | 0.661 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.092564 | 1.034 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.043034 | 1.366 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.043034 | 1.366 |
| R-HSA-69091 | Polymerase switching | 0.230829 | 0.637 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.230829 | 0.637 |
| R-HSA-69109 | Leading Strand Synthesis | 0.230829 | 0.637 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.230829 | 0.637 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.230829 | 0.637 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.230829 | 0.637 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.102739 | 0.988 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.102739 | 0.988 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.102739 | 0.988 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.243349 | 0.614 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.243349 | 0.614 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.113204 | 0.946 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.118535 | 0.926 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.255666 | 0.592 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.255666 | 0.592 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.123928 | 0.907 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.123928 | 0.907 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.129379 | 0.888 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.267783 | 0.572 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.267783 | 0.572 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.267783 | 0.572 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.134885 | 0.870 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.134885 | 0.870 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.076978 | 1.114 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.140442 | 0.853 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.079963 | 1.097 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.151700 | 0.819 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.291431 | 0.535 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.291431 | 0.535 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.302969 | 0.519 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.174703 | 0.758 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.174703 | 0.758 |
| R-HSA-167169 | HIV Transcription Elongation | 0.180539 | 0.743 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.180539 | 0.743 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.180539 | 0.743 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.325484 | 0.487 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.119423 | 0.923 |
| R-HSA-167172 | Transcription of the HIV genome | 0.130234 | 0.885 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.148975 | 0.827 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.027136 | 1.566 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.184662 | 0.734 |
| R-HSA-72187 | mRNA 3'-end processing | 0.258221 | 0.588 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.063395 | 1.198 |
| R-HSA-72172 | mRNA Splicing | 0.077982 | 1.108 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.282386 | 0.549 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.267783 | 0.572 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.037297 | 1.428 |
| R-HSA-157579 | Telomere Maintenance | 0.033797 | 1.471 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.028797 | 1.541 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.027007 | 1.569 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.047639 | 1.322 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.038665 | 1.413 |
| R-HSA-180786 | Extension of Telomeres | 0.098889 | 1.005 |
| R-HSA-73886 | Chromosome Maintenance | 0.073114 | 1.136 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.324458 | 0.489 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.108443 | 0.965 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.039432 | 1.404 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.047164 | 1.326 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.165064 | 0.782 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.230829 | 0.637 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.197025 | 0.705 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.296657 | 0.528 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.296657 | 0.528 |
| R-HSA-162592 | Integration of provirus | 0.218102 | 0.661 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.079963 | 1.097 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.152823 | 0.816 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.108443 | 0.965 |
| R-HSA-8849473 | PTK6 Expression | 0.151254 | 0.820 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.178651 | 0.748 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.092564 | 1.034 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.118535 | 0.926 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.134885 | 0.870 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.291431 | 0.535 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.126592 | 0.898 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.124878 | 0.904 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.154429 | 0.811 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.192017 | 0.717 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.218102 | 0.661 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.129379 | 0.888 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.291431 | 0.535 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.341169 | 0.467 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.045307 | 1.344 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.178651 | 0.748 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.146048 | 0.836 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.163128 | 0.787 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.059689 | 1.224 |
| R-HSA-5693538 | Homology Directed Repair | 0.172959 | 0.762 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.157394 | 0.803 |
| R-HSA-73927 | Depurination | 0.168898 | 0.772 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.301100 | 0.521 |
| R-HSA-162587 | HIV Life Cycle | 0.070223 | 1.154 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.032259 | 1.491 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.063481 | 1.197 |
| R-HSA-75102 | C6 deamination of adenosine | 0.063481 | 1.197 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.151254 | 0.820 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.178651 | 0.748 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.218102 | 0.661 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.218102 | 0.661 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.043034 | 1.366 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.230829 | 0.637 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.243349 | 0.614 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.129379 | 0.888 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.146048 | 0.836 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.146048 | 0.836 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.105564 | 0.976 |
| R-HSA-163615 | PKA activation | 0.314319 | 0.503 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.314319 | 0.503 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.314319 | 0.503 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.325484 | 0.487 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.216083 | 0.665 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.312486 | 0.505 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.064091 | 1.193 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.230829 | 0.637 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.157394 | 0.803 |
| R-HSA-162906 | HIV Infection | 0.114274 | 0.942 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.165064 | 0.782 |
| R-HSA-9930044 | Nuclear RNA decay | 0.134885 | 0.870 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.140442 | 0.853 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.168898 | 0.772 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.145159 | 0.838 |
| R-HSA-196780 | Biotin transport and metabolism | 0.267783 | 0.572 |
| R-HSA-73942 | DNA Damage Reversal | 0.267783 | 0.572 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.076978 | 1.114 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.122947 | 0.910 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.035767 | 1.447 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.137216 | 0.863 |
| R-HSA-75072 | mRNA Editing | 0.178651 | 0.748 |
| R-HSA-164843 | 2-LTR circle formation | 0.192017 | 0.717 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.218102 | 0.661 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.218102 | 0.661 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.243349 | 0.614 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.198213 | 0.703 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.300470 | 0.522 |
| R-HSA-191859 | snRNP Assembly | 0.300470 | 0.522 |
| R-HSA-8953854 | Metabolism of RNA | 0.242258 | 0.616 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.073114 | 1.136 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.136852 | 0.864 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.243349 | 0.614 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.064091 | 1.193 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.146048 | 0.836 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.151700 | 0.819 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.314319 | 0.503 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.145159 | 0.838 |
| R-HSA-877300 | Interferon gamma signaling | 0.330660 | 0.481 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.308594 | 0.511 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.165064 | 0.782 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.178651 | 0.748 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.036570 | 1.437 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.218102 | 0.661 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.230829 | 0.637 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.243349 | 0.614 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.279704 | 0.553 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.180539 | 0.743 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.186405 | 0.730 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.325484 | 0.487 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.181051 | 0.742 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.189129 | 0.723 |
| R-HSA-73894 | DNA Repair | 0.098116 | 1.008 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.060407 | 1.219 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.186405 | 0.730 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.294449 | 0.531 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.178651 | 0.748 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.078570 | 1.105 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.178651 | 0.748 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.197025 | 0.705 |
| R-HSA-73884 | Base Excision Repair | 0.222312 | 0.653 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.054365 | 1.265 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.302969 | 0.519 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.168898 | 0.772 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.222073 | 0.654 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.297495 | 0.527 |
| R-HSA-1500620 | Meiosis | 0.197025 | 0.705 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.270306 | 0.568 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.148176 | 0.829 |
| R-HSA-5617833 | Cilium Assembly | 0.058539 | 1.233 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.168521 | 0.773 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.134417 | 0.872 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.064091 | 1.193 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.243349 | 0.614 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.291431 | 0.535 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.174703 | 0.758 |
| R-HSA-1221632 | Meiotic synapsis | 0.264264 | 0.578 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.318478 | 0.497 |
| R-HSA-9758941 | Gastrulation | 0.293969 | 0.532 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.133448 | 0.875 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.133448 | 0.875 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.092564 | 1.034 |
| R-HSA-9659379 | Sensory processing of sound | 0.172517 | 0.763 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.288420 | 0.540 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.243349 | 0.614 |
| R-HSA-9675135 | Diseases of DNA repair | 0.222073 | 0.654 |
| R-HSA-74160 | Gene expression (Transcription) | 0.136743 | 0.864 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.077912 | 1.108 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.267783 | 0.572 |
| R-HSA-392517 | Rap1 signalling | 0.325484 | 0.487 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.192297 | 0.716 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.130234 | 0.885 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.089602 | 1.048 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.318478 | 0.497 |
| R-HSA-8939211 | ESR-mediated signaling | 0.063315 | 1.198 |
| R-HSA-69275 | G2/M Transition | 0.123252 | 0.909 |
| R-HSA-2028269 | Signaling by Hippo | 0.302969 | 0.519 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.127343 | 0.895 |
| R-HSA-70171 | Glycolysis | 0.274514 | 0.561 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.151254 | 0.820 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.089213 | 1.050 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.108966 | 0.963 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.102739 | 0.988 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.103379 | 0.986 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.089213 | 1.050 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.126826 | 0.897 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.310071 | 0.509 |
| R-HSA-5635838 | Activation of SMO | 0.279704 | 0.553 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.137627 | 0.861 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.205166 | 0.688 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.324918 | 0.488 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.178651 | 0.748 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.073207 | 1.135 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.255666 | 0.592 |
| R-HSA-211000 | Gene Silencing by RNA | 0.309997 | 0.509 |
| R-HSA-913531 | Interferon Signaling | 0.221134 | 0.655 |
| R-HSA-4839726 | Chromatin organization | 0.155937 | 0.807 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.334347 | 0.476 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.267783 | 0.572 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.293995 | 0.532 |
| R-HSA-2559583 | Cellular Senescence | 0.229768 | 0.639 |
| R-HSA-162582 | Signal Transduction | 0.092421 | 1.034 |
| R-HSA-1538133 | G0 and Early G1 | 0.129379 | 0.888 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.054979 | 1.260 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.267783 | 0.572 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.325484 | 0.487 |
| R-HSA-68882 | Mitotic Anaphase | 0.345414 | 0.462 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.174703 | 0.758 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.312263 | 0.505 |
| R-HSA-1483255 | PI Metabolism | 0.283354 | 0.548 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.213808 | 0.670 |
| R-HSA-75153 | Apoptotic execution phase | 0.060155 | 1.221 |
| R-HSA-109581 | Apoptosis | 0.341728 | 0.466 |
| R-HSA-373755 | Semaphorin interactions | 0.324458 | 0.489 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.288420 | 0.540 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.177833 | 0.750 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.087595 | 1.058 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.087595 | 1.058 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.102739 | 0.988 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.036106 | 1.442 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.270105 | 0.568 |
| R-HSA-9607240 | FLT3 Signaling | 0.186405 | 0.730 |
| R-HSA-73887 | Death Receptor Signaling | 0.154429 | 0.811 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.347276 | 0.459 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.347276 | 0.459 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.347276 | 0.459 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.347276 | 0.459 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.348634 | 0.458 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.354132 | 0.451 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.357907 | 0.446 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.357907 | 0.446 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 0.357907 | 0.446 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.357907 | 0.446 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.360014 | 0.444 |
| R-HSA-5619102 | SLC transporter disorders | 0.360196 | 0.443 |
| R-HSA-70326 | Glucose metabolism | 0.363386 | 0.440 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.365877 | 0.437 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.365877 | 0.437 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.368366 | 0.434 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.368366 | 0.434 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.368366 | 0.434 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.368366 | 0.434 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.368366 | 0.434 |
| R-HSA-68875 | Mitotic Prophase | 0.376663 | 0.424 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.377540 | 0.423 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.378654 | 0.422 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.378654 | 0.422 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.378654 | 0.422 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.378654 | 0.422 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.378654 | 0.422 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.378654 | 0.422 |
| R-HSA-429947 | Deadenylation of mRNA | 0.388776 | 0.410 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.388776 | 0.410 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.388776 | 0.410 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.388776 | 0.410 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.388776 | 0.410 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.388776 | 0.410 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.389113 | 0.410 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.394864 | 0.404 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.394864 | 0.404 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.394864 | 0.404 |
| R-HSA-420029 | Tight junction interactions | 0.398734 | 0.399 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.398734 | 0.399 |
| R-HSA-9839394 | TGFBR3 expression | 0.398734 | 0.399 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.398734 | 0.399 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.398734 | 0.399 |
| R-HSA-3214842 | HDMs demethylate histones | 0.398734 | 0.399 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.398734 | 0.399 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.398734 | 0.399 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.408530 | 0.389 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.408530 | 0.389 |
| R-HSA-525793 | Myogenesis | 0.408530 | 0.389 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.408530 | 0.389 |
| R-HSA-3295583 | TRP channels | 0.408530 | 0.389 |
| R-HSA-69481 | G2/M Checkpoints | 0.411759 | 0.385 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.417614 | 0.379 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.417614 | 0.379 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.418167 | 0.379 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.418167 | 0.379 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.418167 | 0.379 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.422674 | 0.374 |
| R-HSA-9833482 | PKR-mediated signaling | 0.423235 | 0.373 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.427648 | 0.369 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.427648 | 0.369 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.427648 | 0.369 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.427648 | 0.369 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.427648 | 0.369 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.427648 | 0.369 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.428827 | 0.368 |
| R-HSA-212436 | Generic Transcription Pathway | 0.430667 | 0.366 |
| R-HSA-72086 | mRNA Capping | 0.436975 | 0.360 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.436975 | 0.360 |
| R-HSA-180024 | DARPP-32 events | 0.436975 | 0.360 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.436975 | 0.360 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.436975 | 0.360 |
| R-HSA-9909396 | Circadian clock | 0.437680 | 0.359 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.445431 | 0.351 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.446150 | 0.351 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.446150 | 0.351 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.446150 | 0.351 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.446150 | 0.351 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.446150 | 0.351 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.455176 | 0.342 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.455176 | 0.342 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.461764 | 0.336 |
| R-HSA-69190 | DNA strand elongation | 0.464056 | 0.333 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.464056 | 0.333 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.467146 | 0.331 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.467361 | 0.330 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.472792 | 0.325 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.472792 | 0.325 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.472792 | 0.325 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.481385 | 0.318 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.481385 | 0.318 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.481385 | 0.318 |
| R-HSA-5673000 | RAF activation | 0.489840 | 0.310 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.489840 | 0.310 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.493224 | 0.307 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.498156 | 0.303 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.498156 | 0.303 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.498156 | 0.303 |
| R-HSA-381042 | PERK regulates gene expression | 0.498156 | 0.303 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.498753 | 0.302 |
| R-HSA-5357801 | Programmed Cell Death | 0.504511 | 0.297 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.506338 | 0.296 |
| R-HSA-111933 | Calmodulin induced events | 0.506338 | 0.296 |
| R-HSA-111997 | CaM pathway | 0.506338 | 0.296 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.506338 | 0.296 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.506338 | 0.296 |
| R-HSA-8853659 | RET signaling | 0.506338 | 0.296 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.514387 | 0.289 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.514387 | 0.289 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.524163 | 0.281 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.524163 | 0.281 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.524163 | 0.281 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.529141 | 0.276 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.530095 | 0.276 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.530095 | 0.276 |
| R-HSA-69306 | DNA Replication | 0.532391 | 0.274 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.537758 | 0.269 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.537758 | 0.269 |
| R-HSA-8982491 | Glycogen metabolism | 0.537758 | 0.269 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.537758 | 0.269 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.537758 | 0.269 |
| R-HSA-3214847 | HATs acetylate histones | 0.538989 | 0.268 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.540206 | 0.267 |
| R-HSA-1989781 | PPARA activates gene expression | 0.540206 | 0.267 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.543860 | 0.265 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.547946 | 0.261 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.552712 | 0.258 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.552712 | 0.258 |
| R-HSA-167161 | HIV Transcription Initiation | 0.552712 | 0.258 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.552712 | 0.258 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.552712 | 0.258 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.552712 | 0.258 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.553495 | 0.257 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.553495 | 0.257 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.553495 | 0.257 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.559413 | 0.252 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.560008 | 0.252 |
| R-HSA-111996 | Ca-dependent events | 0.560008 | 0.252 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.560008 | 0.252 |
| R-HSA-73928 | Depyrimidination | 0.560008 | 0.252 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.560008 | 0.252 |
| R-HSA-165159 | MTOR signalling | 0.560008 | 0.252 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.567185 | 0.246 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.567185 | 0.246 |
| R-HSA-9710421 | Defective pyroptosis | 0.567185 | 0.246 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.574245 | 0.241 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.574245 | 0.241 |
| R-HSA-69236 | G1 Phase | 0.574245 | 0.241 |
| R-HSA-373752 | Netrin-1 signaling | 0.574245 | 0.241 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.574499 | 0.241 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.581191 | 0.236 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.581191 | 0.236 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.581191 | 0.236 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.581191 | 0.236 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.581191 | 0.236 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.586076 | 0.232 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.586076 | 0.232 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.588023 | 0.231 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.588023 | 0.231 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.588023 | 0.231 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.588023 | 0.231 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.588023 | 0.231 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.588023 | 0.231 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.588023 | 0.231 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.590585 | 0.229 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.594745 | 0.226 |
| R-HSA-9634597 | GPER1 signaling | 0.601357 | 0.221 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.601357 | 0.221 |
| R-HSA-425410 | Metal ion SLC transporters | 0.601357 | 0.221 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.603489 | 0.219 |
| R-HSA-73893 | DNA Damage Bypass | 0.607862 | 0.216 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.610547 | 0.214 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.610547 | 0.214 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.614261 | 0.212 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.614261 | 0.212 |
| R-HSA-912446 | Meiotic recombination | 0.620556 | 0.207 |
| R-HSA-9864848 | Complex IV assembly | 0.620556 | 0.207 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.625342 | 0.204 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.625342 | 0.204 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.626749 | 0.203 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.626749 | 0.203 |
| R-HSA-168255 | Influenza Infection | 0.631216 | 0.200 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.632841 | 0.199 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.632841 | 0.199 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.637776 | 0.195 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.638607 | 0.195 |
| R-HSA-72649 | Translation initiation complex formation | 0.638834 | 0.195 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.644730 | 0.191 |
| R-HSA-1500931 | Cell-Cell communication | 0.646286 | 0.190 |
| R-HSA-3371556 | Cellular response to heat stress | 0.649884 | 0.187 |
| R-HSA-421270 | Cell-cell junction organization | 0.650085 | 0.187 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.650529 | 0.187 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.650529 | 0.187 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.650529 | 0.187 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.661847 | 0.179 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.661847 | 0.179 |
| R-HSA-983712 | Ion channel transport | 0.663955 | 0.178 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.667369 | 0.176 |
| R-HSA-186712 | Regulation of beta-cell development | 0.667369 | 0.176 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.669350 | 0.174 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.669350 | 0.174 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.669350 | 0.174 |
| R-HSA-69206 | G1/S Transition | 0.669350 | 0.174 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.672800 | 0.172 |
| R-HSA-983189 | Kinesins | 0.672800 | 0.172 |
| R-HSA-379724 | tRNA Aminoacylation | 0.672800 | 0.172 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.672800 | 0.172 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.678143 | 0.169 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.678143 | 0.169 |
| R-HSA-112043 | PLC beta mediated events | 0.678143 | 0.169 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.683050 | 0.166 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.683399 | 0.165 |
| R-HSA-9707616 | Heme signaling | 0.683399 | 0.165 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.683399 | 0.165 |
| R-HSA-9609690 | HCMV Early Events | 0.685592 | 0.164 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.685592 | 0.164 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.688570 | 0.162 |
| R-HSA-8848021 | Signaling by PTK6 | 0.688570 | 0.162 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.693656 | 0.159 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.693656 | 0.159 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.698660 | 0.156 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.698669 | 0.156 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.703582 | 0.153 |
| R-HSA-112040 | G-protein mediated events | 0.708425 | 0.150 |
| R-HSA-422475 | Axon guidance | 0.712260 | 0.147 |
| R-HSA-446728 | Cell junction organization | 0.721124 | 0.142 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.722484 | 0.141 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.727018 | 0.138 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.727018 | 0.138 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.727018 | 0.138 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.727018 | 0.138 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.727018 | 0.138 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.731479 | 0.136 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.733779 | 0.134 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.736424 | 0.133 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.738588 | 0.132 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.740184 | 0.131 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.741703 | 0.130 |
| R-HSA-8852135 | Protein ubiquitination | 0.744430 | 0.128 |
| R-HSA-418990 | Adherens junctions interactions | 0.749340 | 0.125 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.756759 | 0.121 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.756759 | 0.121 |
| R-HSA-1483257 | Phospholipid metabolism | 0.760081 | 0.119 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.762631 | 0.118 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.764647 | 0.117 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.764647 | 0.117 |
| R-HSA-195721 | Signaling by WNT | 0.766501 | 0.115 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.768335 | 0.114 |
| R-HSA-199991 | Membrane Trafficking | 0.770788 | 0.113 |
| R-HSA-9675108 | Nervous system development | 0.774447 | 0.111 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.776004 | 0.110 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.779667 | 0.108 |
| R-HSA-9610379 | HCMV Late Events | 0.782078 | 0.107 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.783270 | 0.106 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.784739 | 0.105 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.786815 | 0.104 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.816824 | 0.088 |
| R-HSA-72306 | tRNA processing | 0.816824 | 0.088 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.819234 | 0.087 |
| R-HSA-9609646 | HCMV Infection | 0.820381 | 0.086 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.822193 | 0.085 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.827966 | 0.082 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.827966 | 0.082 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.827984 | 0.082 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.833552 | 0.079 |
| R-HSA-190236 | Signaling by FGFR | 0.833552 | 0.079 |
| R-HSA-422356 | Regulation of insulin secretion | 0.833552 | 0.079 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.846739 | 0.072 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.849249 | 0.071 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.849249 | 0.071 |
| R-HSA-111885 | Opioid Signalling | 0.849249 | 0.071 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.853337 | 0.069 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.853349 | 0.069 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.854195 | 0.068 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.856536 | 0.067 |
| R-HSA-69239 | Synthesis of DNA | 0.858886 | 0.066 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.861197 | 0.065 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.861197 | 0.065 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.861498 | 0.065 |
| R-HSA-1266738 | Developmental Biology | 0.861819 | 0.065 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.863471 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.863846 | 0.064 |
| R-HSA-6803157 | Antimicrobial peptides | 0.867908 | 0.062 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.874296 | 0.058 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.875112 | 0.058 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.876333 | 0.057 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.878383 | 0.056 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.879892 | 0.056 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.880376 | 0.055 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.882337 | 0.054 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.882337 | 0.054 |
| R-HSA-373760 | L1CAM interactions | 0.882337 | 0.054 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.883180 | 0.054 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.884266 | 0.053 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.891671 | 0.050 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.892126 | 0.050 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.895195 | 0.048 |
| R-HSA-194138 | Signaling by VEGF | 0.900267 | 0.046 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.901903 | 0.045 |
| R-HSA-112316 | Neuronal System | 0.904812 | 0.043 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.908184 | 0.042 |
| R-HSA-9843745 | Adipogenesis | 0.911172 | 0.040 |
| R-HSA-5576891 | Cardiac conduction | 0.911172 | 0.040 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.913080 | 0.039 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.914776 | 0.039 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.917023 | 0.038 |
| R-HSA-72312 | rRNA processing | 0.919216 | 0.037 |
| R-HSA-163685 | Integration of energy metabolism | 0.919568 | 0.036 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.921161 | 0.036 |
| R-HSA-5368287 | Mitochondrial translation | 0.922187 | 0.035 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.922187 | 0.035 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.923465 | 0.035 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.924721 | 0.034 |
| R-HSA-9664407 | Parasite infection | 0.924721 | 0.034 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.924721 | 0.034 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.925958 | 0.033 |
| R-HSA-1632852 | Macroautophagy | 0.925958 | 0.033 |
| R-HSA-69242 | S Phase | 0.935145 | 0.029 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.937120 | 0.028 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.937259 | 0.028 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.938290 | 0.028 |
| R-HSA-72766 | Translation | 0.938474 | 0.028 |
| R-HSA-5688426 | Deubiquitination | 0.940810 | 0.026 |
| R-HSA-9612973 | Autophagy | 0.943197 | 0.025 |
| R-HSA-9711097 | Cellular response to starvation | 0.945049 | 0.025 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.950470 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.953937 | 0.020 |
| R-HSA-418555 | G alpha (s) signalling events | 0.956434 | 0.019 |
| R-HSA-2262752 | Cellular responses to stress | 0.956783 | 0.019 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.957150 | 0.019 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.957856 | 0.019 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.957856 | 0.019 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.957856 | 0.019 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.958549 | 0.018 |
| R-HSA-9658195 | Leishmania infection | 0.958618 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.958618 | 0.018 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.959188 | 0.018 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.959231 | 0.018 |
| R-HSA-611105 | Respiratory electron transport | 0.961211 | 0.017 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.965956 | 0.015 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.971693 | 0.012 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.973084 | 0.012 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.974393 | 0.011 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.974393 | 0.011 |
| R-HSA-8957322 | Metabolism of steroids | 0.977390 | 0.010 |
| R-HSA-397014 | Muscle contraction | 0.978316 | 0.010 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.979232 | 0.009 |
| R-HSA-8951664 | Neddylation | 0.981332 | 0.008 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.984189 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.985088 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.987268 | 0.006 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.989581 | 0.005 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.990482 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.990732 | 0.004 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.992284 | 0.003 |
| R-HSA-1643685 | Disease | 0.994915 | 0.002 |
| R-HSA-9679506 | SARS-CoV Infections | 0.996097 | 0.002 |
| R-HSA-9824446 | Viral Infection Pathways | 0.996628 | 0.001 |
| R-HSA-6798695 | Neutrophil degranulation | 0.996816 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.996910 | 0.001 |
| R-HSA-1474244 | Extracellular matrix organization | 0.997027 | 0.001 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.997486 | 0.001 |
| R-HSA-449147 | Signaling by Interleukins | 0.998531 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998918 | 0.000 |
| R-HSA-418594 | G alpha (i) signalling events | 0.999185 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999418 | 0.000 |
| R-HSA-1280218 | Adaptive Immune System | 0.999658 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999835 | 0.000 |
| R-HSA-109582 | Hemostasis | 0.999854 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999959 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999969 | 0.000 |
| R-HSA-168256 | Immune System | 0.999980 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999996 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.855 | 0.779 | 1 | 0.737 |
CDK1 |
0.845 | 0.828 | 1 | 0.796 |
P38G |
0.844 | 0.863 | 1 | 0.861 |
CDK3 |
0.844 | 0.753 | 1 | 0.843 |
CDK18 |
0.839 | 0.817 | 1 | 0.817 |
CDK17 |
0.838 | 0.835 | 1 | 0.852 |
HIPK2 |
0.836 | 0.748 | 1 | 0.801 |
P38D |
0.834 | 0.833 | 1 | 0.855 |
JNK2 |
0.833 | 0.855 | 1 | 0.816 |
CDK19 |
0.832 | 0.783 | 1 | 0.800 |
ERK1 |
0.831 | 0.814 | 1 | 0.798 |
CDK13 |
0.831 | 0.823 | 1 | 0.790 |
CDK5 |
0.831 | 0.800 | 1 | 0.736 |
CDK8 |
0.829 | 0.790 | 1 | 0.762 |
CDK12 |
0.829 | 0.823 | 1 | 0.813 |
JNK3 |
0.829 | 0.853 | 1 | 0.785 |
CDK16 |
0.827 | 0.794 | 1 | 0.837 |
P38B |
0.827 | 0.813 | 1 | 0.780 |
CLK3 |
0.823 | 0.520 | 1 | 0.446 |
DYRK2 |
0.822 | 0.730 | 1 | 0.708 |
DYRK4 |
0.819 | 0.742 | 1 | 0.810 |
CDK7 |
0.818 | 0.771 | 1 | 0.766 |
CDK10 |
0.818 | 0.753 | 1 | 0.793 |
CDK14 |
0.816 | 0.784 | 1 | 0.775 |
ERK2 |
0.814 | 0.807 | 1 | 0.746 |
P38A |
0.813 | 0.778 | 1 | 0.706 |
JNK1 |
0.813 | 0.769 | 1 | 0.817 |
CDK9 |
0.812 | 0.782 | 1 | 0.783 |
HIPK1 |
0.811 | 0.671 | 1 | 0.687 |
DYRK1B |
0.807 | 0.698 | 1 | 0.763 |
NLK |
0.807 | 0.731 | 1 | 0.487 |
CDK6 |
0.806 | 0.776 | 1 | 0.795 |
CDK4 |
0.804 | 0.788 | 1 | 0.822 |
SRPK1 |
0.803 | 0.353 | -3 | 0.727 |
CDK2 |
0.803 | 0.626 | 1 | 0.665 |
CLK2 |
0.799 | 0.423 | -3 | 0.723 |
HIPK4 |
0.798 | 0.439 | 1 | 0.484 |
ERK5 |
0.795 | 0.403 | 1 | 0.399 |
HIPK3 |
0.795 | 0.644 | 1 | 0.660 |
DYRK1A |
0.795 | 0.577 | 1 | 0.667 |
MTOR |
0.793 | 0.274 | 1 | 0.278 |
DYRK3 |
0.791 | 0.533 | 1 | 0.650 |
COT |
0.791 | 0.025 | 2 | 0.905 |
CLK4 |
0.789 | 0.379 | -3 | 0.735 |
CLK1 |
0.789 | 0.403 | -3 | 0.703 |
SRPK2 |
0.788 | 0.277 | -3 | 0.640 |
PRP4 |
0.788 | 0.510 | -3 | 0.812 |
MAK |
0.783 | 0.483 | -2 | 0.729 |
SRPK3 |
0.781 | 0.263 | -3 | 0.691 |
MOS |
0.780 | 0.056 | 1 | 0.144 |
ICK |
0.778 | 0.330 | -3 | 0.807 |
NEK6 |
0.773 | -0.003 | -2 | 0.866 |
GRK1 |
0.773 | 0.044 | -2 | 0.785 |
IKKB |
0.772 | -0.094 | -2 | 0.734 |
CDKL5 |
0.772 | 0.137 | -3 | 0.757 |
CDKL1 |
0.772 | 0.121 | -3 | 0.765 |
DSTYK |
0.771 | -0.073 | 2 | 0.909 |
GRK7 |
0.770 | 0.063 | 1 | 0.123 |
CDC7 |
0.769 | -0.105 | 1 | 0.104 |
PRPK |
0.767 | -0.088 | -1 | 0.822 |
ATR |
0.767 | -0.040 | 1 | 0.141 |
TBK1 |
0.766 | -0.154 | 1 | 0.072 |
GCN2 |
0.766 | -0.153 | 2 | 0.816 |
BMPR1B |
0.766 | 0.022 | 1 | 0.077 |
MLK1 |
0.765 | -0.062 | 2 | 0.856 |
MST4 |
0.765 | -0.018 | 2 | 0.872 |
IKKE |
0.765 | -0.147 | 1 | 0.071 |
ERK7 |
0.764 | 0.270 | 2 | 0.572 |
RAF1 |
0.764 | -0.159 | 1 | 0.087 |
BMPR2 |
0.764 | -0.096 | -2 | 0.884 |
PIM3 |
0.764 | -0.046 | -3 | 0.819 |
NEK7 |
0.763 | -0.111 | -3 | 0.816 |
PKN3 |
0.762 | -0.040 | -3 | 0.787 |
MOK |
0.762 | 0.422 | 1 | 0.572 |
CAMK1B |
0.762 | -0.039 | -3 | 0.817 |
SKMLCK |
0.761 | -0.019 | -2 | 0.867 |
MLK3 |
0.761 | 0.012 | 2 | 0.793 |
GRK5 |
0.761 | -0.079 | -3 | 0.844 |
CHAK2 |
0.761 | -0.044 | -1 | 0.823 |
PKN2 |
0.761 | -0.038 | -3 | 0.799 |
PDHK4 |
0.760 | -0.174 | 1 | 0.154 |
NDR2 |
0.760 | -0.056 | -3 | 0.832 |
IKKA |
0.760 | -0.060 | -2 | 0.724 |
NUAK2 |
0.760 | -0.003 | -3 | 0.807 |
GSK3A |
0.760 | 0.235 | 4 | 0.510 |
PRKD1 |
0.759 | -0.020 | -3 | 0.792 |
ULK2 |
0.759 | -0.175 | 2 | 0.812 |
TGFBR2 |
0.758 | -0.059 | -2 | 0.834 |
CAMK2G |
0.758 | -0.089 | 2 | 0.809 |
NIK |
0.757 | -0.053 | -3 | 0.839 |
PKCD |
0.757 | -0.011 | 2 | 0.828 |
GRK6 |
0.757 | -0.072 | 1 | 0.087 |
RIPK3 |
0.757 | -0.127 | 3 | 0.743 |
PRKD2 |
0.756 | -0.009 | -3 | 0.737 |
PIM1 |
0.755 | -0.001 | -3 | 0.761 |
WNK1 |
0.755 | -0.097 | -2 | 0.864 |
IRE1 |
0.754 | -0.058 | 1 | 0.087 |
PDHK1 |
0.754 | -0.194 | 1 | 0.131 |
RSK2 |
0.753 | -0.029 | -3 | 0.739 |
DLK |
0.753 | -0.124 | 1 | 0.101 |
CAMLCK |
0.753 | -0.029 | -2 | 0.856 |
ATM |
0.752 | -0.067 | 1 | 0.112 |
NDR1 |
0.752 | -0.085 | -3 | 0.808 |
GRK4 |
0.752 | -0.096 | -2 | 0.831 |
CK1E |
0.752 | 0.050 | -3 | 0.637 |
PINK1 |
0.751 | 0.190 | 1 | 0.305 |
TGFBR1 |
0.751 | -0.012 | -2 | 0.841 |
ALK4 |
0.751 | -0.018 | -2 | 0.862 |
BCKDK |
0.751 | -0.132 | -1 | 0.807 |
PKCB |
0.751 | -0.007 | 2 | 0.792 |
ULK1 |
0.751 | -0.167 | -3 | 0.774 |
AURC |
0.751 | 0.013 | -2 | 0.684 |
DAPK2 |
0.750 | -0.056 | -3 | 0.825 |
ANKRD3 |
0.750 | -0.118 | 1 | 0.104 |
MLK2 |
0.750 | -0.096 | 2 | 0.849 |
NEK9 |
0.750 | -0.150 | 2 | 0.862 |
P90RSK |
0.749 | -0.036 | -3 | 0.743 |
HUNK |
0.749 | -0.154 | 2 | 0.839 |
CK1D |
0.749 | 0.084 | -3 | 0.594 |
FAM20C |
0.749 | -0.008 | 2 | 0.606 |
MNK2 |
0.748 | -0.018 | -2 | 0.797 |
PKCG |
0.748 | -0.021 | 2 | 0.794 |
MLK4 |
0.748 | -0.050 | 2 | 0.763 |
ACVR2B |
0.748 | -0.042 | -2 | 0.832 |
PKCA |
0.748 | -0.003 | 2 | 0.778 |
LATS1 |
0.748 | -0.002 | -3 | 0.848 |
MAPKAPK2 |
0.747 | -0.042 | -3 | 0.699 |
ACVR2A |
0.747 | -0.047 | -2 | 0.820 |
YSK4 |
0.747 | -0.108 | 1 | 0.075 |
PKR |
0.747 | -0.059 | 1 | 0.105 |
PLK1 |
0.746 | -0.096 | -2 | 0.825 |
TTBK2 |
0.746 | -0.154 | 2 | 0.729 |
PHKG1 |
0.746 | -0.062 | -3 | 0.792 |
AMPKA1 |
0.746 | -0.100 | -3 | 0.820 |
MAPKAPK3 |
0.746 | -0.080 | -3 | 0.733 |
TSSK2 |
0.746 | -0.084 | -5 | 0.715 |
PKACG |
0.746 | -0.051 | -2 | 0.750 |
RSK3 |
0.746 | -0.057 | -3 | 0.721 |
IRE2 |
0.746 | -0.059 | 2 | 0.799 |
P70S6KB |
0.745 | -0.047 | -3 | 0.750 |
DNAPK |
0.745 | -0.051 | 1 | 0.140 |
VRK2 |
0.745 | 0.068 | 1 | 0.190 |
PKCZ |
0.745 | -0.034 | 2 | 0.819 |
LATS2 |
0.745 | -0.083 | -5 | 0.563 |
MEKK3 |
0.745 | -0.059 | 1 | 0.096 |
BMPR1A |
0.744 | -0.016 | 1 | 0.069 |
MNK1 |
0.744 | -0.015 | -2 | 0.804 |
GRK2 |
0.744 | -0.047 | -2 | 0.724 |
MASTL |
0.744 | -0.184 | -2 | 0.793 |
MPSK1 |
0.744 | 0.056 | 1 | 0.159 |
ALK2 |
0.744 | -0.033 | -2 | 0.847 |
MST3 |
0.743 | 0.009 | 2 | 0.872 |
CAMK2D |
0.742 | -0.119 | -3 | 0.790 |
PKCH |
0.742 | -0.047 | 2 | 0.779 |
TLK2 |
0.742 | -0.092 | 1 | 0.079 |
SMG1 |
0.741 | -0.077 | 1 | 0.128 |
AMPKA2 |
0.741 | -0.083 | -3 | 0.787 |
TSSK1 |
0.741 | -0.077 | -3 | 0.840 |
PAK1 |
0.741 | -0.058 | -2 | 0.793 |
RIPK1 |
0.741 | -0.204 | 1 | 0.081 |
CK1G1 |
0.741 | 0.006 | -3 | 0.635 |
PRKD3 |
0.741 | -0.034 | -3 | 0.696 |
CK1A2 |
0.741 | 0.051 | -3 | 0.590 |
AKT2 |
0.740 | 0.013 | -3 | 0.652 |
TAO3 |
0.740 | 0.007 | 1 | 0.122 |
PKACB |
0.740 | 0.001 | -2 | 0.701 |
CAMK2B |
0.740 | -0.068 | 2 | 0.773 |
CAMK2A |
0.739 | -0.037 | 2 | 0.790 |
MARK4 |
0.739 | -0.124 | 4 | 0.803 |
WNK3 |
0.739 | -0.247 | 1 | 0.089 |
PAK6 |
0.739 | -0.015 | -2 | 0.715 |
CHAK1 |
0.739 | -0.115 | 2 | 0.798 |
ZAK |
0.739 | -0.094 | 1 | 0.085 |
CAMK4 |
0.739 | -0.129 | -3 | 0.776 |
MEKK2 |
0.739 | -0.049 | 2 | 0.834 |
MEK1 |
0.739 | -0.127 | 2 | 0.854 |
MSK2 |
0.738 | -0.060 | -3 | 0.709 |
RSK4 |
0.737 | -0.034 | -3 | 0.725 |
PRKX |
0.737 | 0.013 | -3 | 0.669 |
NEK2 |
0.737 | -0.131 | 2 | 0.840 |
PAK3 |
0.737 | -0.091 | -2 | 0.788 |
PKG2 |
0.736 | -0.023 | -2 | 0.694 |
GRK3 |
0.736 | -0.039 | -2 | 0.688 |
GSK3B |
0.735 | 0.071 | 4 | 0.502 |
MEKK1 |
0.735 | -0.110 | 1 | 0.098 |
NUAK1 |
0.735 | -0.076 | -3 | 0.744 |
AURA |
0.735 | -0.019 | -2 | 0.662 |
PLK4 |
0.735 | -0.118 | 2 | 0.670 |
NIM1 |
0.735 | -0.133 | 3 | 0.770 |
MEK5 |
0.735 | -0.106 | 2 | 0.847 |
TLK1 |
0.734 | -0.099 | -2 | 0.855 |
DRAK1 |
0.734 | -0.128 | 1 | 0.074 |
SGK3 |
0.734 | -0.039 | -3 | 0.727 |
NEK5 |
0.734 | -0.088 | 1 | 0.084 |
AURB |
0.734 | -0.026 | -2 | 0.682 |
MYLK4 |
0.732 | -0.054 | -2 | 0.789 |
HRI |
0.732 | -0.130 | -2 | 0.854 |
GAK |
0.732 | -0.003 | 1 | 0.143 |
MSK1 |
0.732 | -0.042 | -3 | 0.707 |
PLK3 |
0.732 | -0.118 | 2 | 0.776 |
CK2A2 |
0.732 | -0.031 | 1 | 0.068 |
PERK |
0.731 | -0.126 | -2 | 0.844 |
PAK2 |
0.731 | -0.091 | -2 | 0.775 |
PASK |
0.730 | -0.043 | -3 | 0.843 |
MELK |
0.730 | -0.120 | -3 | 0.759 |
GCK |
0.730 | -0.019 | 1 | 0.101 |
PKCT |
0.730 | -0.053 | 2 | 0.783 |
DCAMKL1 |
0.729 | -0.067 | -3 | 0.753 |
PKCE |
0.729 | 0.010 | 2 | 0.780 |
CAMK1G |
0.729 | -0.075 | -3 | 0.707 |
NEK8 |
0.729 | -0.093 | 2 | 0.852 |
AKT1 |
0.729 | -0.007 | -3 | 0.673 |
IRAK4 |
0.729 | -0.116 | 1 | 0.069 |
BRAF |
0.728 | -0.122 | -4 | 0.803 |
PIM2 |
0.728 | -0.027 | -3 | 0.702 |
NEK11 |
0.728 | -0.099 | 1 | 0.117 |
QIK |
0.727 | -0.151 | -3 | 0.784 |
PHKG2 |
0.727 | -0.087 | -3 | 0.745 |
BUB1 |
0.727 | 0.048 | -5 | 0.686 |
EEF2K |
0.727 | -0.003 | 3 | 0.885 |
TNIK |
0.726 | 0.010 | 3 | 0.914 |
PDK1 |
0.726 | -0.054 | 1 | 0.132 |
QSK |
0.726 | -0.096 | 4 | 0.780 |
CK2A1 |
0.725 | -0.036 | 1 | 0.062 |
HASPIN |
0.725 | 0.052 | -1 | 0.686 |
PKCI |
0.725 | -0.034 | 2 | 0.790 |
TAO2 |
0.725 | -0.036 | 2 | 0.879 |
MAPKAPK5 |
0.724 | -0.120 | -3 | 0.657 |
MST2 |
0.724 | -0.071 | 1 | 0.083 |
LKB1 |
0.724 | -0.022 | -3 | 0.811 |
HGK |
0.723 | -0.030 | 3 | 0.911 |
DCAMKL2 |
0.723 | -0.078 | -3 | 0.765 |
CHK1 |
0.723 | -0.118 | -3 | 0.776 |
HPK1 |
0.723 | -0.034 | 1 | 0.103 |
MAP3K15 |
0.723 | -0.075 | 1 | 0.099 |
WNK4 |
0.723 | -0.159 | -2 | 0.851 |
KHS2 |
0.723 | 0.024 | 1 | 0.107 |
MINK |
0.722 | -0.068 | 1 | 0.075 |
SIK |
0.721 | -0.106 | -3 | 0.713 |
SMMLCK |
0.721 | -0.062 | -3 | 0.768 |
BRSK1 |
0.720 | -0.120 | -3 | 0.746 |
KHS1 |
0.720 | -0.011 | 1 | 0.095 |
PKACA |
0.719 | -0.022 | -2 | 0.652 |
BRSK2 |
0.719 | -0.148 | -3 | 0.766 |
SSTK |
0.719 | -0.084 | 4 | 0.772 |
PAK5 |
0.719 | -0.048 | -2 | 0.648 |
TTBK1 |
0.719 | -0.160 | 2 | 0.648 |
CK1A |
0.718 | 0.049 | -3 | 0.516 |
SNRK |
0.718 | -0.191 | 2 | 0.709 |
PKN1 |
0.718 | -0.049 | -3 | 0.670 |
MARK3 |
0.718 | -0.103 | 4 | 0.737 |
TAK1 |
0.717 | -0.110 | 1 | 0.077 |
PAK4 |
0.716 | -0.035 | -2 | 0.660 |
OSR1 |
0.716 | 0.006 | 2 | 0.816 |
NEK4 |
0.716 | -0.141 | 1 | 0.074 |
CAMKK1 |
0.716 | -0.165 | -2 | 0.745 |
MEKK6 |
0.715 | -0.112 | 1 | 0.096 |
DAPK3 |
0.714 | -0.054 | -3 | 0.767 |
LRRK2 |
0.714 | -0.031 | 2 | 0.869 |
AKT3 |
0.714 | -0.008 | -3 | 0.600 |
MST1 |
0.713 | -0.093 | 1 | 0.074 |
NEK1 |
0.713 | -0.113 | 1 | 0.069 |
MARK2 |
0.713 | -0.126 | 4 | 0.687 |
VRK1 |
0.713 | -0.124 | 2 | 0.883 |
SGK1 |
0.712 | -0.001 | -3 | 0.579 |
CHK2 |
0.711 | -0.039 | -3 | 0.593 |
SLK |
0.711 | -0.070 | -2 | 0.678 |
PLK2 |
0.711 | -0.073 | -3 | 0.739 |
LOK |
0.711 | -0.083 | -2 | 0.740 |
P70S6K |
0.711 | -0.087 | -3 | 0.651 |
CAMKK2 |
0.710 | -0.142 | -2 | 0.736 |
TTK |
0.710 | -0.012 | -2 | 0.845 |
CAMK1D |
0.710 | -0.072 | -3 | 0.642 |
PDHK3_TYR |
0.710 | 0.151 | 4 | 0.893 |
YSK1 |
0.710 | -0.088 | 2 | 0.836 |
SBK |
0.710 | 0.074 | -3 | 0.530 |
DAPK1 |
0.709 | -0.055 | -3 | 0.750 |
PDHK4_TYR |
0.708 | 0.130 | 2 | 0.880 |
ROCK2 |
0.707 | -0.039 | -3 | 0.758 |
MARK1 |
0.707 | -0.151 | 4 | 0.760 |
PBK |
0.706 | -0.063 | 1 | 0.127 |
MRCKB |
0.706 | -0.036 | -3 | 0.692 |
BIKE |
0.706 | -0.024 | 1 | 0.142 |
STK33 |
0.706 | -0.118 | 2 | 0.636 |
IRAK1 |
0.705 | -0.239 | -1 | 0.716 |
AAK1 |
0.705 | 0.011 | 1 | 0.156 |
CAMK1A |
0.704 | -0.046 | -3 | 0.612 |
RIPK2 |
0.704 | -0.203 | 1 | 0.072 |
MAP2K6_TYR |
0.703 | 0.088 | -1 | 0.863 |
TESK1_TYR |
0.701 | 0.045 | 3 | 0.887 |
MAP2K4_TYR |
0.701 | 0.052 | -1 | 0.848 |
BMPR2_TYR |
0.701 | 0.061 | -1 | 0.866 |
MRCKA |
0.701 | -0.063 | -3 | 0.712 |
DMPK1 |
0.700 | -0.009 | -3 | 0.723 |
MYO3B |
0.700 | -0.034 | 2 | 0.852 |
ASK1 |
0.700 | -0.093 | 1 | 0.099 |
PDHK1_TYR |
0.699 | 0.018 | -1 | 0.877 |
MYO3A |
0.699 | -0.043 | 1 | 0.095 |
LIMK2_TYR |
0.698 | 0.089 | -3 | 0.854 |
TAO1 |
0.698 | -0.065 | 1 | 0.095 |
ALPHAK3 |
0.697 | -0.064 | -1 | 0.760 |
CK1G3 |
0.696 | 0.040 | -3 | 0.473 |
MEK2 |
0.696 | -0.209 | 2 | 0.829 |
PKMYT1_TYR |
0.696 | 0.062 | 3 | 0.855 |
PINK1_TYR |
0.695 | -0.076 | 1 | 0.146 |
MAP2K7_TYR |
0.695 | -0.067 | 2 | 0.872 |
NEK3 |
0.694 | -0.149 | 1 | 0.100 |
ROCK1 |
0.693 | -0.048 | -3 | 0.710 |
YANK3 |
0.692 | -0.049 | 2 | 0.406 |
RET |
0.691 | -0.114 | 1 | 0.114 |
CSF1R |
0.691 | -0.050 | 3 | 0.802 |
JAK2 |
0.690 | -0.080 | 1 | 0.123 |
PKG1 |
0.689 | -0.063 | -2 | 0.617 |
TYK2 |
0.689 | -0.151 | 1 | 0.100 |
CRIK |
0.688 | -0.047 | -3 | 0.675 |
JAK3 |
0.688 | -0.070 | 1 | 0.109 |
LIMK1_TYR |
0.687 | -0.021 | 2 | 0.872 |
MST1R |
0.687 | -0.094 | 3 | 0.820 |
ABL2 |
0.687 | -0.073 | -1 | 0.783 |
EPHA6 |
0.686 | -0.086 | -1 | 0.873 |
EPHB4 |
0.685 | -0.098 | -1 | 0.839 |
STLK3 |
0.685 | -0.142 | 1 | 0.071 |
TXK |
0.685 | -0.059 | 1 | 0.071 |
ROS1 |
0.685 | -0.104 | 3 | 0.785 |
LCK |
0.685 | -0.043 | -1 | 0.803 |
FGR |
0.684 | -0.113 | 1 | 0.076 |
KDR |
0.684 | -0.042 | 3 | 0.752 |
BLK |
0.684 | -0.034 | -1 | 0.812 |
KIT |
0.683 | -0.075 | 3 | 0.793 |
JAK1 |
0.683 | -0.072 | 1 | 0.097 |
YES1 |
0.683 | -0.082 | -1 | 0.798 |
ABL1 |
0.682 | -0.085 | -1 | 0.769 |
FLT1 |
0.682 | -0.041 | -1 | 0.856 |
TYRO3 |
0.682 | -0.139 | 3 | 0.814 |
INSRR |
0.681 | -0.096 | 3 | 0.745 |
CK1G2 |
0.681 | 0.029 | -3 | 0.558 |
FGFR2 |
0.681 | -0.040 | 3 | 0.775 |
HCK |
0.680 | -0.098 | -1 | 0.794 |
NEK10_TYR |
0.680 | -0.114 | 1 | 0.103 |
TNNI3K_TYR |
0.680 | -0.032 | 1 | 0.127 |
MET |
0.679 | -0.066 | 3 | 0.784 |
FLT3 |
0.679 | -0.137 | 3 | 0.812 |
FYN |
0.677 | -0.042 | -1 | 0.781 |
FER |
0.677 | -0.164 | 1 | 0.087 |
WEE1_TYR |
0.677 | -0.042 | -1 | 0.710 |
SYK |
0.677 | -0.005 | -1 | 0.803 |
FGFR1 |
0.676 | -0.055 | 3 | 0.752 |
FGFR3 |
0.676 | -0.029 | 3 | 0.745 |
EGFR |
0.675 | -0.066 | 1 | 0.070 |
DDR1 |
0.675 | -0.154 | 4 | 0.802 |
PDGFRB |
0.674 | -0.176 | 3 | 0.810 |
EPHA4 |
0.674 | -0.090 | 2 | 0.773 |
EPHB1 |
0.674 | -0.155 | 1 | 0.068 |
ITK |
0.673 | -0.127 | -1 | 0.762 |
TNK1 |
0.672 | -0.090 | 3 | 0.791 |
FRK |
0.672 | -0.102 | -1 | 0.816 |
EPHB2 |
0.671 | -0.130 | -1 | 0.820 |
ERBB2 |
0.671 | -0.121 | 1 | 0.087 |
BMX |
0.671 | -0.096 | -1 | 0.683 |
EPHB3 |
0.671 | -0.149 | -1 | 0.827 |
SRMS |
0.670 | -0.172 | 1 | 0.063 |
TEK |
0.669 | -0.053 | 3 | 0.728 |
PTK2 |
0.669 | -0.017 | -1 | 0.817 |
TNK2 |
0.668 | -0.150 | 3 | 0.750 |
ZAP70 |
0.667 | -0.000 | -1 | 0.707 |
PDGFRA |
0.667 | -0.197 | 3 | 0.815 |
TEC |
0.667 | -0.131 | -1 | 0.687 |
MERTK |
0.667 | -0.154 | 3 | 0.764 |
FLT4 |
0.667 | -0.121 | 3 | 0.739 |
FGFR4 |
0.666 | -0.069 | -1 | 0.762 |
DDR2 |
0.665 | -0.048 | 3 | 0.721 |
SRC |
0.664 | -0.091 | -1 | 0.771 |
INSR |
0.664 | -0.140 | 3 | 0.729 |
BTK |
0.664 | -0.189 | -1 | 0.718 |
LYN |
0.664 | -0.113 | 3 | 0.718 |
NTRK1 |
0.664 | -0.189 | -1 | 0.809 |
MUSK |
0.663 | -0.101 | 1 | 0.054 |
ALK |
0.663 | -0.156 | 3 | 0.718 |
MATK |
0.663 | -0.088 | -1 | 0.720 |
EPHA7 |
0.663 | -0.130 | 2 | 0.778 |
NTRK3 |
0.663 | -0.136 | -1 | 0.766 |
ERBB4 |
0.662 | -0.058 | 1 | 0.068 |
YANK2 |
0.662 | -0.058 | 2 | 0.421 |
AXL |
0.662 | -0.193 | 3 | 0.764 |
EPHA8 |
0.661 | -0.101 | -1 | 0.821 |
NTRK2 |
0.661 | -0.193 | 3 | 0.753 |
EPHA3 |
0.659 | -0.139 | 2 | 0.749 |
LTK |
0.659 | -0.178 | 3 | 0.732 |
PTK6 |
0.658 | -0.200 | -1 | 0.688 |
EPHA5 |
0.658 | -0.130 | 2 | 0.759 |
EPHA1 |
0.656 | -0.179 | 3 | 0.762 |
PTK2B |
0.655 | -0.130 | -1 | 0.723 |
CSK |
0.653 | -0.152 | 2 | 0.782 |
EPHA2 |
0.652 | -0.106 | -1 | 0.794 |
IGF1R |
0.652 | -0.120 | 3 | 0.656 |
FES |
0.630 | -0.154 | -1 | 0.659 |