Motif 257 (n=164)

Position-wise Probabilities
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uniprot genes site source protein function
A0A0C4DFX4 None S255 ochoa Snf2 related CREBBP activator protein None
A0A1W2PPC1 PRR33 S317 ochoa Proline rich 33 None
A6NEL2 SOWAHB S258 ochoa Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) None
A7MCY6 TBKBP1 S385 ochoa TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}.
A8MZF0 PRR33 S169 ochoa Proline-rich protein 33 None
H3BNR1 BORCS8-MEF2B S211 ochoa BORCS8-MEF2B readthrough None
O00204 SULT2B1 S318 ochoa Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}.
O14578 CIT S1940 ochoa Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.
O14654 IRS4 S872 ochoa Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.
O14733 MAP2K7 S61 ochoa Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.
O15297 PPM1D S85 ochoa|psp Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23242139}.
O43295 SRGAP3 S874 ochoa SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
O43516 WIPF1 S244 ochoa WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
O43524 FOXO3 S43 ochoa Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}.
O60244 MED14 S1142 ochoa Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}.
O75112 LDB3 S129 ochoa LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.
O75362 ZNF217 S848 ochoa Zinc finger protein 217 Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.
O75665 OFD1 S669 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O94819 KBTBD11 S93 ochoa Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) None
O95343 SIX3 S302 ochoa Homeobox protein SIX3 (Sine oculis homeobox homolog 3) Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 also functions in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. {ECO:0000250|UniProtKB:Q62233, ECO:0000269|PubMed:18791198}.
O95644 NFATC1 S409 psp Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
P03372 ESR1 S104 psp Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.
P08651 NFIC S470 ochoa Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
P10588 NR2F6 S40 ochoa Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.
P10636 MAPT S238 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P12270 TPR S2073 ochoa|psp Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}.
P14859 POU2F1 S448 ochoa POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}.
P15407 FOSL1 S191 ochoa Fos-related antigen 1 (FRA-1) None
P15927 RPA2 S29 ochoa|psp Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}.
P17302 GJA1 S279 ochoa|psp Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
P17931 LGALS3 Y79 psp Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076, ECO:0000269|PubMed:27693506}.
P32927 CSF2RB S665 ochoa Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}.
P42694 HELZ T1163 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P42695 NCAPD3 S1329 ochoa Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}.
P46109 CRKL S222 ochoa Crk-like protein May mediate the transduction of intracellular signals.
P48730 CSNK1D S356 ochoa Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.
P51532 SMARCA4 S132 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P52824 DGKQ S26 ochoa Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}.
P55198 MLLT6 S429 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P55198 MLLT6 S435 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P78559 MAP1A S2629 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q02080 MEF2B S194 ochoa Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Q02952 AKAP12 S749 ochoa A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03001 DST S7432 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03060 CREM S277 psp cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.
Q04725 TLE2 S193 ochoa Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
Q04725 TLE2 S313 ochoa Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
Q06587 RING1 S254 ochoa E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
Q06945 SOX4 S354 ochoa Transcription factor SOX-4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}.
Q10571 MN1 S1081 ochoa Transcriptional activator MN1 (Probable tumor suppressor protein MN1) Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.
Q13428 TCOF1 S233 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13469 NFATC2 S79 psp Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q14160 SCRIB S1547 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14669 TRIP12 S1036 ochoa E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}.
Q14676 MDC1 S964 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14686 NCOA6 S1751 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q14764 MVP S873 ochoa Major vault protein (MVP) (Lung resistance-related protein) Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
Q14814 MEF2D S251 ochoa|psp Myocyte-specific enhancer factor 2D Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.
Q15003 NCAPH S28 ochoa Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15596 NCOA2 S499 ochoa|psp Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
Q15723 ELF2 S430 ochoa ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; FUNCTION: Isoform 2 may function in repression of RUNX1-mediated transactivation.
Q15772 SPEG S2177 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q4L180 FILIP1L S1019 ochoa Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1) Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269|PubMed:18794120}.
Q53F19 NCBP3 S506 ochoa Nuclear cap-binding protein subunit 3 (Protein ELG) Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.
Q5JTD0 TJAP1 S214 ochoa Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}.
Q5VV41 ARHGEF16 S41 ochoa Rho guanine nucleotide exchange factor 16 (Ephexin-4) Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.
Q66K14 TBC1D9B S420 ochoa TBC1 domain family member 9B May act as a GTPase-activating protein for Rab family protein(s).
Q66K74 MAP1S S632 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q6KC79 NIPBL S280 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NUJ5 PWWP2B S84 ochoa PWWP domain-containing protein 2B Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
Q6NV74 CRACDL S646 ochoa CRACD-like protein None
Q6P2E9 EDC4 S780 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6PJF5 RHBDF2 S177 ochoa Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}.
Q6UXY1 BAIAP2L2 S231 ochoa BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.
Q6ZRS2 SRCAP S274 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZU65 UBN2 S1042 ochoa Ubinuclein-2 None
Q6ZU65 UBN2 S1048 ochoa Ubinuclein-2 None
Q6ZU65 UBN2 S1054 ochoa Ubinuclein-2 None
Q6ZVM7 TOM1L2 S194 ochoa TOM1-like protein 2 (Target of Myb-like protein 2) Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}.
Q6ZW31 SYDE1 S66 ochoa Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.
Q76NI1 KNDC1 S392 ochoa Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.
Q7L311 ARMCX2 S244 ochoa Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}.
Q7Z2K8 GPRIN1 S615 ochoa G protein-regulated inducer of neurite outgrowth 1 (GRIN1) May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z2Z1 TICRR S1352 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z5J4 RAI1 S345 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q86VM9 ZC3H18 S868 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q8IWC1 MAP7D3 S322 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8IWZ8 SUGP1 S344 ochoa SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) Plays a role in pre-mRNA splicing.
Q8IX07 ZFPM1 S512 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IYB3 SRRM1 S775 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IZD0 SAMD14 S288 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8IZT6 ASPM S35 ochoa Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}.
Q8IZW8 TNS4 S248 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8N3D4 EHBP1L1 S245 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N3V7 SYNPO S899 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8NB15 ZNF511 S214 ochoa Zinc finger protein 511 May be involved in transcriptional regulation. {ECO:0000305}.
Q8NC56 LEMD2 S166 ochoa LEM domain-containing protein 2 (hLEM2) Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). {ECO:0000250|UniProtKB:Q6DVA0, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}.
Q8TBB5 KLHDC4 S424 ochoa Kelch domain-containing protein 4 None
Q8TD16 BICD2 S574 ochoa Protein bicaudal D homolog 2 (Bic-D 2) Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}.
Q8TDY2 RB1CC1 S653 ochoa RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.
Q8TED9 AFAP1L1 S104 ochoa Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}.
Q8TEK3 DOT1L S1065 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8WUF5 PPP1R13L S358 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WVB6 CHTF18 S871 ochoa Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}.
Q8WWM7 ATXN2L S32 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WXD9 CASKIN1 S1242 ochoa Caskin-1 (CASK-interacting protein 1) May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WYP5 AHCTF1 S1087 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92619 ARHGAP45 S99 ochoa Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
Q92729 PTPRU S853 ochoa Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}.
Q92766 RREB1 S42 ochoa Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.
Q96C12 ARMC5 S102 ochoa Armadillo repeat-containing protein 5 Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}.
Q96GM8 TOE1 S428 ochoa Target of EGR1 protein 1 Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). {ECO:0000269|PubMed:12562764, ECO:0000269|PubMed:28092684}.
Q96I34 PPP1R16A S478 ochoa Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}.
Q96NA2 RILP S361 ochoa Rab-interacting lysosomal protein Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11179213, PubMed:11696325, PubMed:12944476, PubMed:14668488, PubMed:27113757). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}.
Q96NU1 SAMD11 S646 ochoa Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}.
Q96NY9 MUS81 S101 ochoa Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog) Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:11741546, PubMed:12374758, PubMed:12686547, PubMed:12721304, PubMed:24371268, PubMed:24733841, PubMed:24813886, PubMed:35290797, PubMed:39015284). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs (PubMed:24371268, PubMed:24733841, PubMed:35290797). MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:24813886). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork (PubMed:24813886). MUS81-EME2 could also function in telomere maintenance (PubMed:24813886). MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (PubMed:11741546, PubMed:12374758, PubMed:14617801, PubMed:15805243, PubMed:24813886). {ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758, ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243, ECO:0000269|PubMed:24371268, ECO:0000269|PubMed:24733841, ECO:0000269|PubMed:24813886, ECO:0000269|PubMed:35290797, ECO:0000269|PubMed:39015284}.
Q96T58 SPEN S2120 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q96T58 SPEN S2126 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99081 TCF12 S354 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99575 POP1 S730 ochoa Ribonucleases P/MRP protein subunit POP1 (hPOP1) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}.
Q9BRD0 BUD13 S364 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BRQ0 PYGO2 S97 ochoa Pygopus homolog 2 Involved in signal transduction through the Wnt pathway.
Q9BWT3 PAPOLG S29 ochoa Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}.
Q9BYB0 SHANK3 S366 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9H1H9 KIF13A S1460 ochoa Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
Q9H1R3 MYLK2 S149 ochoa Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}.
Q9H211 CDT1 S79 ochoa DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H2D6 TRIOBP S1955 ochoa TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.
Q9H2I8 LRMDA S153 ochoa Leucine-rich melanocyte differentiation-associated protein Required for melanocyte differentiation. {ECO:0000269|PubMed:23395477}.
Q9H4Z2 ZNF335 S992 ochoa Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}.
Q9H6K5 PRR36 S116 ochoa Proline-rich protein 36 None
Q9H6R4 NOL6 S289 ochoa Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}.
Q9H8M5 CNNM2 S749 ochoa Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO:0000250|UniProtKB:Q3TWN3}.
Q9H9D4 ZNF408 S338 ochoa Zinc finger protein 408 (PR domain zinc finger protein 17) May be involved in transcriptional regulation.
Q9HAU0 PLEKHA5 S1098 ochoa Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) None
Q9HBE1 PATZ1 S249 ochoa POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}.
Q9HC35 EML4 S144 ochoa|psp Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.
Q9HCM7 FBRSL1 S141 ochoa Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) None
Q9NQS7 INCENP S269 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NQS7 INCENP S312 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NUE0 ZDHHC18 S30 ochoa Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}.
Q9NWS9 ZNF446 S188 ochoa Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) May be involved in transcriptional regulation.
Q9NYL2 MAP3K20 S733 ochoa Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.
Q9NZM4 BICRA S1534 ochoa BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}.
Q9NZT2 OGFR S525 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9NZT2 OGFR S585 ochoa Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Q9P206 NHSL3 S286 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P242 NYAP2 S413 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P270 SLAIN2 S462 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UD71 PPP1R1B S52 ochoa Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) Inhibitor of protein-phosphatase 1.
Q9UGP4 LIMD1 S353 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UGY1 NOL12 S140 ochoa Nucleolar protein 12 Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}.
Q9ULD5 ZNF777 S502 ochoa Zinc finger protein 777 May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}.
Q9ULM3 YEATS2 S124 ochoa YEATS domain-containing protein 2 Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}.
Q9UM47 NOTCH3 S2032 ochoa Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}.
Q9UN79 SOX13 S83 ochoa Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
Q9UPQ9 TNRC6B S1336 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UQ35 SRRM2 S2382 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2H5 PLEKHA6 S282 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y4F5 CEP170B S518 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y618 NCOR2 S2413 psp Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:10077563, ECO:0000269|PubMed:10097068, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289}.; FUNCTION: [Isoform 1]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.; FUNCTION: [Isoform 4]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.
Q9Y6J0 CABIN1 S2100 ochoa Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.
V9GYY5 None S133 ochoa Nucleolar protein 12 Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}.
P08151 GLI1 S608 GPS6 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
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reactome_id name p -log10_p
R-HSA-2025928 Calcineurin activates NFAT 0.000370 3.432
R-HSA-8878171 Transcriptional regulation by RUNX1 0.000548 3.261
R-HSA-525793 Myogenesis 0.000520 3.284
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.001189 2.925
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.002187 2.660
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.001675 2.776
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.001967 2.706
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.003831 2.417
R-HSA-1640170 Cell Cycle 0.003980 2.400
R-HSA-69278 Cell Cycle, Mitotic 0.002938 2.532
R-HSA-162582 Signal Transduction 0.003157 2.501
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.007084 2.150
R-HSA-9909396 Circadian clock 0.007114 2.148
R-HSA-68962 Activation of the pre-replicative complex 0.008202 2.086
R-HSA-8939211 ESR-mediated signaling 0.009358 2.029
R-HSA-74160 Gene expression (Transcription) 0.009109 2.041
R-HSA-9707616 Heme signaling 0.008565 2.067
R-HSA-195721 Signaling by WNT 0.010741 1.969
R-HSA-191650 Regulation of gap junction activity 0.065577 1.183
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.065577 1.183
R-HSA-5083630 Defective LFNG causes SCDO3 0.065577 1.183
R-HSA-9017802 Noncanonical activation of NOTCH3 0.086471 1.063
R-HSA-5688890 Defective CSF2RA causes SMDP4 0.086471 1.063
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.086471 1.063
R-HSA-5688849 Defective CSF2RB causes SMDP5 0.086471 1.063
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.016188 1.791
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.106901 0.971
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.106901 0.971
R-HSA-196025 Formation of annular gap junctions 0.116944 0.932
R-HSA-8875656 MET receptor recycling 0.116944 0.932
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.116944 0.932
R-HSA-9020958 Interleukin-21 signaling 0.126876 0.897
R-HSA-190873 Gap junction degradation 0.126876 0.897
R-HSA-9700645 ALK mutants bind TKIs 0.126876 0.897
R-HSA-8875555 MET activates RAP1 and RAC1 0.136696 0.864
R-HSA-350054 Notch-HLH transcription pathway 0.040527 1.392
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.146407 0.834
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.156008 0.807
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.174891 0.757
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.193353 0.714
R-HSA-9027284 Erythropoietin activates RAS 0.193353 0.714
R-HSA-5656121 Translesion synthesis by POLI 0.202430 0.694
R-HSA-5655862 Translesion synthesis by POLK 0.211405 0.675
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.220279 0.657
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.229054 0.640
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.237731 0.624
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.110335 0.957
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.246311 0.609
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.246311 0.609
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.263184 0.580
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.263184 0.580
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.263184 0.580
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.271479 0.566
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.271479 0.566
R-HSA-383280 Nuclear Receptor transcription pathway 0.074730 1.127
R-HSA-8943723 Regulation of PTEN mRNA translation 0.279681 0.553
R-HSA-912526 Interleukin receptor SHC signaling 0.279681 0.553
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.326999 0.485
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.191934 0.717
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.191934 0.717
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.334580 0.476
R-HSA-8854518 AURKA Activation by TPX2 0.204198 0.690
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.342075 0.466
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.342075 0.466
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.356814 0.448
R-HSA-1855170 IPs transport between nucleus and cytosol 0.356814 0.448
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.356814 0.448
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.233108 0.632
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.233108 0.632
R-HSA-380287 Centrosome maturation 0.241420 0.617
R-HSA-1989781 PPARA activates gene expression 0.133901 0.873
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.270586 0.568
R-HSA-141424 Amplification of signal from the kinetochores 0.287252 0.542
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.287252 0.542
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.299728 0.523
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.137909 0.860
R-HSA-9018519 Estrogen-dependent gene expression 0.030796 1.512
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.229054 0.640
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.334580 0.476
R-HSA-72163 mRNA Splicing - Major Pathway 0.221988 0.654
R-HSA-5656169 Termination of translesion DNA synthesis 0.326999 0.485
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.308026 0.511
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.075553 1.122
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.075553 1.122
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.075553 1.122
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.287791 0.541
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.295810 0.529
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.263184 0.580
R-HSA-110312 Translesion synthesis by REV1 0.193353 0.714
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.158150 0.801
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 0.076083 1.119
R-HSA-9839394 TGFBR3 expression 0.048608 1.313
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.165503 0.781
R-HSA-69166 Removal of the Flap Intermediate 0.184174 0.735
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.211405 0.675
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.220279 0.657
R-HSA-110320 Translesion Synthesis by POLH 0.237731 0.624
R-HSA-73863 RNA Polymerase I Transcription Termination 0.311580 0.506
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.250904 0.600
R-HSA-3928664 Ephrin signaling 0.229054 0.640
R-HSA-4641265 Repression of WNT target genes 0.165503 0.781
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.034060 1.468
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.076083 1.119
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.184174 0.735
R-HSA-190872 Transport of connexons to the plasma membrane 0.229054 0.640
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.254795 0.594
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.319333 0.496
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.356814 0.448
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.110335 0.957
R-HSA-72172 mRNA Splicing 0.248510 0.605
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.146407 0.834
R-HSA-68877 Mitotic Prometaphase 0.034406 1.463
R-HSA-180024 DARPP-32 events 0.326999 0.485
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.303740 0.517
R-HSA-4608870 Asymmetric localization of PCP proteins 0.121360 0.916
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.054469 1.264
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.046801 1.330
R-HSA-5693607 Processing of DNA double-strand break ends 0.266417 0.574
R-HSA-9006931 Signaling by Nuclear Receptors 0.031079 1.508
R-HSA-190827 Transport of connexins along the secretory pathway 0.033341 1.477
R-HSA-8875513 MET interacts with TNS proteins 0.054952 1.260
R-HSA-8964540 Alanine metabolism 0.065577 1.183
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.096743 1.014
R-HSA-2470946 Cohesin Loading onto Chromatin 0.106901 0.971
R-HSA-446107 Type I hemidesmosome assembly 0.116944 0.932
R-HSA-428543 Inactivation of CDC42 and RAC1 0.126876 0.897
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.079113 1.102
R-HSA-8875878 MET promotes cell motility 0.092613 1.033
R-HSA-73980 RNA Polymerase III Transcription Termination 0.229054 0.640
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.114658 0.941
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.228959 0.640
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.262247 0.581
R-HSA-9009391 Extra-nuclear estrogen signaling 0.039187 1.407
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.106722 0.972
R-HSA-176187 Activation of ATR in response to replication stress 0.356814 0.448
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.027580 1.559
R-HSA-69183 Processive synthesis on the lagging strand 0.193353 0.714
R-HSA-9620244 Long-term potentiation 0.295810 0.529
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.311580 0.506
R-HSA-68886 M Phase 0.017044 1.768
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.171797 0.765
R-HSA-9930044 Nuclear RNA decay 0.072618 1.139
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.072618 1.139
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.303740 0.517
R-HSA-5693532 DNA Double-Strand Break Repair 0.305010 0.516
R-HSA-9843745 Adipogenesis 0.086613 1.062
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.039629 1.402
R-HSA-157118 Signaling by NOTCH 0.076229 1.118
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.054290 1.265
R-HSA-5632684 Hedgehog 'on' state 0.224815 0.648
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.237731 0.624
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.212422 0.673
R-HSA-212165 Epigenetic regulation of gene expression 0.095985 1.018
R-HSA-9932451 SWI/SNF chromatin remodelers 0.048608 1.313
R-HSA-9932444 ATP-dependent chromatin remodelers 0.048608 1.313
R-HSA-5693538 Homology Directed Repair 0.188595 0.724
R-HSA-69002 DNA Replication Pre-Initiation 0.158150 0.801
R-HSA-190704 Oligomerization of connexins into connexons 0.033341 1.477
R-HSA-9729555 Sensory perception of sour taste 0.065577 1.183
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.156008 0.807
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.211405 0.675
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.356814 0.448
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.278922 0.555
R-HSA-68875 Mitotic Prophase 0.194287 0.712
R-HSA-9006335 Signaling by Erythropoietin 0.326999 0.485
R-HSA-1257604 PIP3 activates AKT signaling 0.148507 0.828
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.303740 0.517
R-HSA-5610787 Hedgehog 'off' state 0.131971 0.880
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.085781 1.067
R-HSA-2980766 Nuclear Envelope Breakdown 0.167743 0.775
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.334580 0.476
R-HSA-5687613 Diseases associated with surfactant metabolism 0.165503 0.781
R-HSA-9022692 Regulation of MECP2 expression and activity 0.072618 1.139
R-HSA-912631 Regulation of signaling by CBL 0.237731 0.624
R-HSA-180786 Extension of Telomeres 0.175750 0.755
R-HSA-6784531 tRNA processing in the nucleus 0.187869 0.726
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.356814 0.448
R-HSA-5358351 Signaling by Hedgehog 0.256199 0.591
R-HSA-74158 RNA Polymerase III Transcription 0.085781 1.067
R-HSA-69186 Lagging Strand Synthesis 0.254795 0.594
R-HSA-8863678 Neurodegenerative Diseases 0.287791 0.541
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.287791 0.541
R-HSA-6783310 Fanconi Anemia Pathway 0.121360 0.916
R-HSA-9839373 Signaling by TGFBR3 0.125094 0.903
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.065577 1.183
R-HSA-389542 NADPH regeneration 0.096743 1.014
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.126876 0.897
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.156008 0.807
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.165503 0.781
R-HSA-9945266 Differentiation of T cells 0.202430 0.694
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.202430 0.694
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.263184 0.580
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.171739 0.765
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.311580 0.506
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.208305 0.681
R-HSA-69473 G2/M DNA damage checkpoint 0.237262 0.625
R-HSA-9006925 Intracellular signaling by second messengers 0.227649 0.643
R-HSA-157579 Telomere Maintenance 0.345087 0.462
R-HSA-170968 Frs2-mediated activation 0.174891 0.757
R-HSA-9662834 CD163 mediating an anti-inflammatory response 0.146407 0.834
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.165503 0.781
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.220279 0.657
R-HSA-69306 DNA Replication 0.305010 0.516
R-HSA-9005895 Pervasive developmental disorders 0.165503 0.781
R-HSA-9697154 Disorders of Nervous System Development 0.165503 0.781
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.165503 0.781
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.184174 0.735
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.193353 0.714
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.220279 0.657
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.254795 0.594
R-HSA-200425 Carnitine shuttle 0.279681 0.553
R-HSA-156584 Cytosolic sulfonation of small molecules 0.144151 0.841
R-HSA-69190 DNA strand elongation 0.349486 0.457
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.249745 0.603
R-HSA-8953854 Metabolism of RNA 0.262855 0.580
R-HSA-451927 Interleukin-2 family signaling 0.099596 1.002
R-HSA-9768759 Regulation of NPAS4 gene expression 0.220279 0.657
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.180142 0.744
R-HSA-438064 Post NMDA receptor activation events 0.295573 0.529
R-HSA-5358508 Mismatch Repair 0.229054 0.640
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.074730 1.127
R-HSA-2559580 Oxidative Stress Induced Senescence 0.137078 0.863
R-HSA-201681 TCF dependent signaling in response to WNT 0.080529 1.094
R-HSA-73857 RNA Polymerase II Transcription 0.030225 1.520
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.023989 1.620
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.184174 0.735
R-HSA-9675151 Disorders of Developmental Biology 0.211405 0.675
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.229054 0.640
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.279681 0.553
R-HSA-4086400 PCP/CE pathway 0.253911 0.595
R-HSA-212436 Generic Transcription Pathway 0.031912 1.496
R-HSA-4839726 Chromatin organization 0.086323 1.064
R-HSA-169893 Prolonged ERK activation events 0.202430 0.694
R-HSA-3858494 Beta-catenin independent WNT signaling 0.096682 1.015
R-HSA-6806834 Signaling by MET 0.262247 0.581
R-HSA-9659379 Sensory processing of sound 0.258078 0.588
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.174891 0.757
R-HSA-4086398 Ca2+ pathway 0.233108 0.632
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.042651 1.370
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.263184 0.580
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.326999 0.485
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.212422 0.673
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.202904 0.693
R-HSA-9031628 NGF-stimulated transcription 0.026239 1.581
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.082426 1.084
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.059420 1.226
R-HSA-3214847 HATs acetylate histones 0.353242 0.452
R-HSA-69206 G1/S Transition 0.075553 1.122
R-HSA-428643 Organic anion transport by SLC5/17/25 transporters 0.229054 0.640
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.163764 0.786
R-HSA-186763 Downstream signal transduction 0.342075 0.466
R-HSA-5687128 MAPK6/MAPK4 signaling 0.283088 0.548
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.356814 0.448
R-HSA-159418 Recycling of bile acids and salts 0.356814 0.448
R-HSA-3247509 Chromatin modifying enzymes 0.162062 0.790
R-HSA-8986944 Transcriptional Regulation by MECP2 0.027580 1.559
R-HSA-1852241 Organelle biogenesis and maintenance 0.340140 0.468
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.226754 0.644
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.063226 1.199
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.136455 0.865
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.349486 0.457
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.173813 0.760
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.173813 0.760
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.059420 1.226
R-HSA-446728 Cell junction organization 0.248800 0.604
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.063094 1.200
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.126876 0.897
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.174891 0.757
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.226293 0.645
R-HSA-2559583 Cellular Senescence 0.189456 0.722
R-HSA-418990 Adherens junctions interactions 0.283175 0.548
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.063856 1.195
R-HSA-1500931 Cell-Cell communication 0.331256 0.480
R-HSA-1181150 Signaling by NODAL 0.246311 0.609
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.311580 0.506
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.116487 0.934
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.080200 1.096
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.051421 1.289
R-HSA-69205 G1/S-Specific Transcription 0.085781 1.067
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.191934 0.717
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.117655 0.929
R-HSA-449147 Signaling by Interleukins 0.308971 0.510
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.080879 1.092
R-HSA-8878166 Transcriptional regulation by RUNX2 0.065262 1.185
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.243634 0.613
R-HSA-9006936 Signaling by TGFB family members 0.326532 0.486
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.258078 0.588
R-HSA-2262752 Cellular responses to stress 0.287225 0.542
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.079113 1.102
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.279681 0.553
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.303740 0.517
R-HSA-1592230 Mitochondrial biogenesis 0.185766 0.731
R-HSA-8953897 Cellular responses to stimuli 0.339898 0.469
R-HSA-1980143 Signaling by NOTCH1 0.245581 0.610
R-HSA-5210891 Uptake and function of anthrax toxins 0.220279 0.657
R-HSA-166520 Signaling by NTRKs 0.120267 0.920
R-HSA-9707564 Cytoprotection by HMOX1 0.085097 1.070
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.121968 0.914
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.320380 0.494
R-HSA-1266695 Interleukin-7 signaling 0.295810 0.529
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.187869 0.726
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.356814 0.448
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.349486 0.457
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.217249 0.663
R-HSA-69618 Mitotic Spindle Checkpoint 0.357307 0.447
R-HSA-70171 Glycolysis 0.357307 0.447
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.360328 0.443
R-HSA-5621481 C-type lectin receptors (CLRs) 0.363391 0.440
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.364061 0.439
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.364061 0.439
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.364061 0.439
R-HSA-5693537 Resolution of D-Loop Structures 0.364061 0.439
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.364061 0.439
R-HSA-114508 Effects of PIP2 hydrolysis 0.364061 0.439
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.365408 0.437
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.365408 0.437
R-HSA-1483255 PI Metabolism 0.365408 0.437
R-HSA-421270 Cell-cell junction organization 0.366974 0.435
R-HSA-5696400 Dual Incision in GG-NER 0.371226 0.430
R-HSA-190861 Gap junction assembly 0.371226 0.430
R-HSA-180746 Nuclear import of Rev protein 0.371226 0.430
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.371226 0.430
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.371226 0.430
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.377487 0.423
R-HSA-5619507 Activation of HOX genes during differentiation 0.377487 0.423
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.378310 0.422
R-HSA-2559585 Oncogene Induced Senescence 0.378310 0.422
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.378310 0.422
R-HSA-187687 Signalling to ERKs 0.378310 0.422
R-HSA-69620 Cell Cycle Checkpoints 0.384824 0.415
R-HSA-3371511 HSF1 activation 0.385316 0.414
R-HSA-8853659 RET signaling 0.385316 0.414
R-HSA-69239 Synthesis of DNA 0.389471 0.410
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.389471 0.410
R-HSA-9700206 Signaling by ALK in cancer 0.389471 0.410
R-HSA-211000 Gene Silencing by RNA 0.389471 0.410
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.392242 0.406
R-HSA-5689896 Ovarian tumor domain proteases 0.392242 0.406
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.393443 0.405
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.399092 0.399
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.399092 0.399
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.403157 0.395
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.405864 0.392
R-HSA-8953750 Transcriptional Regulation by E2F6 0.405864 0.392
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.405864 0.392
R-HSA-69275 G2/M Transition 0.408989 0.388
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.412561 0.385
R-HSA-177243 Interactions of Rev with host cellular proteins 0.412561 0.385
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.412561 0.385
R-HSA-1251985 Nuclear signaling by ERBB4 0.412561 0.385
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.412561 0.385
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.415003 0.382
R-HSA-453274 Mitotic G2-G2/M phases 0.415003 0.382
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.419182 0.378
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.419182 0.378
R-HSA-8853884 Transcriptional Regulation by VENTX 0.419182 0.378
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.419182 0.378
R-HSA-3214841 PKMTs methylate histone lysines 0.419182 0.378
R-HSA-9607240 FLT3 Signaling 0.419182 0.378
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.419182 0.378
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.425729 0.371
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.425729 0.371
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.425729 0.371
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.426428 0.370
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.432203 0.364
R-HSA-70326 Glucose metabolism 0.436319 0.360
R-HSA-1433557 Signaling by SCF-KIT 0.438604 0.358
R-HSA-190828 Gap junction trafficking 0.444934 0.352
R-HSA-3214858 RMTs methylate histone arginines 0.444934 0.352
R-HSA-5683826 Surfactant metabolism 0.444934 0.352
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.451192 0.346
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.451192 0.346
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.451507 0.345
R-HSA-73886 Chromosome Maintenance 0.451507 0.345
R-HSA-3371556 Cellular response to heat stress 0.451507 0.345
R-HSA-2299718 Condensation of Prophase Chromosomes 0.457380 0.340
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.457380 0.340
R-HSA-9675135 Diseases of DNA repair 0.457380 0.340
R-HSA-75153 Apoptotic execution phase 0.457380 0.340
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.469550 0.328
R-HSA-3700989 Transcriptional Regulation by TP53 0.471155 0.327
R-HSA-73893 DNA Damage Bypass 0.475532 0.323
R-HSA-157858 Gap junction trafficking and regulation 0.475532 0.323
R-HSA-69481 G2/M Checkpoints 0.477520 0.321
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.487296 0.312
R-HSA-912446 Meiotic recombination 0.487296 0.312
R-HSA-72187 mRNA 3'-end processing 0.493079 0.307
R-HSA-73772 RNA Polymerase I Promoter Escape 0.493079 0.307
R-HSA-68949 Orc1 removal from chromatin 0.493079 0.307
R-HSA-6794361 Neurexins and neuroligins 0.493079 0.307
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.493079 0.307
R-HSA-5339562 Uptake and actions of bacterial toxins 0.493079 0.307
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.498798 0.302
R-HSA-68882 Mitotic Anaphase 0.499556 0.301
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.502366 0.299
R-HSA-9012852 Signaling by NOTCH3 0.510043 0.292
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.510043 0.292
R-HSA-3214815 HDACs deacetylate histones 0.510043 0.292
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.515571 0.288
R-HSA-193648 NRAGE signals death through JNK 0.515571 0.288
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.515571 0.288
R-HSA-6782135 Dual incision in TC-NER 0.526442 0.279
R-HSA-6807070 PTEN Regulation 0.527233 0.278
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.531786 0.274
R-HSA-191859 snRNP Assembly 0.531786 0.274
R-HSA-194441 Metabolism of non-coding RNA 0.531786 0.274
R-HSA-429914 Deadenylation-dependent mRNA decay 0.531786 0.274
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.531786 0.274
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.537070 0.270
R-HSA-8943724 Regulation of PTEN gene transcription 0.537070 0.270
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.537070 0.270
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.537070 0.270
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.537070 0.270
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.537070 0.270
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.537070 0.270
R-HSA-168325 Viral Messenger RNA Synthesis 0.542295 0.266
R-HSA-73856 RNA Polymerase II Transcription Termination 0.542295 0.266
R-HSA-2428928 IRS-related events triggered by IGF1R 0.542295 0.266
R-HSA-211976 Endogenous sterols 0.542295 0.266
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.542295 0.266
R-HSA-450294 MAP kinase activation 0.542295 0.266
R-HSA-72312 rRNA processing 0.543521 0.265
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.547461 0.262
R-HSA-186797 Signaling by PDGF 0.547461 0.262
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.552569 0.258
R-HSA-2428924 IGF1R signaling cascade 0.557620 0.254
R-HSA-69242 S Phase 0.560746 0.251
R-HSA-1234174 Cellular response to hypoxia 0.562614 0.250
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.562614 0.250
R-HSA-9856651 MITF-M-dependent gene expression 0.567243 0.246
R-HSA-5693606 DNA Double Strand Break Response 0.572435 0.242
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.572435 0.242
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.580031 0.237
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.586756 0.232
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.586756 0.232
R-HSA-204005 COPII-mediated vesicle transport 0.586756 0.232
R-HSA-448424 Interleukin-17 signaling 0.586756 0.232
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.591423 0.228
R-HSA-427413 NoRC negatively regulates rRNA expression 0.591423 0.228
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.591423 0.228
R-HSA-8978934 Metabolism of cofactors 0.591423 0.228
R-HSA-5578749 Transcriptional regulation by small RNAs 0.596037 0.225
R-HSA-5683057 MAPK family signaling cascades 0.597371 0.224
R-HSA-5633007 Regulation of TP53 Activity 0.598691 0.223
R-HSA-69052 Switching of origins to a post-replicative state 0.600600 0.221
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.600600 0.221
R-HSA-1236394 Signaling by ERBB4 0.605111 0.218
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.609572 0.215
R-HSA-71403 Citric acid cycle (TCA cycle) 0.609572 0.215
R-HSA-1169408 ISG15 antiviral mechanism 0.609572 0.215
R-HSA-2467813 Separation of Sister Chromatids 0.610784 0.214
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.613983 0.212
R-HSA-73864 RNA Polymerase I Transcription 0.622656 0.206
R-HSA-9955298 SLC-mediated transport of organic anions 0.622656 0.206
R-HSA-416482 G alpha (12/13) signalling events 0.622656 0.206
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.631135 0.200
R-HSA-9833482 PKR-mediated signaling 0.631135 0.200
R-HSA-72306 tRNA processing 0.631279 0.200
R-HSA-9711123 Cellular response to chemical stress 0.633781 0.198
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.647529 0.189
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.647529 0.189
R-HSA-1500620 Meiosis 0.651513 0.186
R-HSA-6794362 Protein-protein interactions at synapses 0.651513 0.186
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.659348 0.181
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.659348 0.181
R-HSA-390466 Chaperonin-mediated protein folding 0.663199 0.178
R-HSA-70268 Pyruvate metabolism 0.663199 0.178
R-HSA-9645723 Diseases of programmed cell death 0.667007 0.176
R-HSA-73884 Base Excision Repair 0.674494 0.171
R-HSA-5617833 Cilium Assembly 0.685210 0.164
R-HSA-2682334 EPH-Ephrin signaling 0.685413 0.164
R-HSA-391251 Protein folding 0.685413 0.164
R-HSA-68867 Assembly of the pre-replicative complex 0.688971 0.162
R-HSA-1474290 Collagen formation 0.692489 0.160
R-HSA-1280215 Cytokine Signaling in Immune system 0.699149 0.155
R-HSA-9609690 HCMV Early Events 0.700084 0.155
R-HSA-8878159 Transcriptional regulation by RUNX3 0.706170 0.151
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.706170 0.151
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.709494 0.149
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.709494 0.149
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.709494 0.149
R-HSA-9614085 FOXO-mediated transcription 0.712782 0.147
R-HSA-192105 Synthesis of bile acids and bile salts 0.712782 0.147
R-HSA-193704 p75 NTR receptor-mediated signalling 0.712782 0.147
R-HSA-9842860 Regulation of endogenous retroelements 0.722423 0.141
R-HSA-111885 Opioid Signalling 0.728670 0.137
R-HSA-9833110 RSV-host interactions 0.731742 0.136
R-HSA-5696398 Nucleotide Excision Repair 0.734778 0.134
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.734778 0.134
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.739097 0.131
R-HSA-9730414 MITF-M-regulated melanocyte development 0.741252 0.130
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.743685 0.129
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.746587 0.127
R-HSA-194068 Bile acid and bile salt metabolism 0.749457 0.125
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.749457 0.125
R-HSA-166166 MyD88-independent TLR4 cascade 0.749457 0.125
R-HSA-1483249 Inositol phosphate metabolism 0.755099 0.122
R-HSA-2871796 FCERI mediated MAPK activation 0.755099 0.122
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.757873 0.120
R-HSA-9855142 Cellular responses to mechanical stimuli 0.760615 0.119
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.766008 0.116
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.766008 0.116
R-HSA-9705683 SARS-CoV-2-host interactions 0.771798 0.112
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.778966 0.108
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.778966 0.108
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.786396 0.104
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.786396 0.104
R-HSA-2132295 MHC class II antigen presentation 0.788817 0.103
R-HSA-162909 Host Interactions of HIV factors 0.791211 0.102
R-HSA-6798695 Neutrophil degranulation 0.791275 0.102
R-HSA-156580 Phase II - Conjugation of compounds 0.792167 0.101
R-HSA-73894 DNA Repair 0.805434 0.094
R-HSA-1474165 Reproduction 0.809414 0.092
R-HSA-9609646 HCMV Infection 0.810923 0.091
R-HSA-9717189 Sensory perception of taste 0.811576 0.091
R-HSA-8856688 Golgi-to-ER retrograde transport 0.813713 0.090
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.826039 0.083
R-HSA-9734767 Developmental Cell Lineages 0.831143 0.080
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.831894 0.080
R-HSA-9664417 Leishmania phagocytosis 0.831894 0.080
R-HSA-9664407 Parasite infection 0.831894 0.080
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.833802 0.079
R-HSA-1632852 Macroautophagy 0.833802 0.079
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.837553 0.077
R-HSA-162599 Late Phase of HIV Life Cycle 0.837553 0.077
R-HSA-199977 ER to Golgi Anterograde Transport 0.846567 0.072
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.848309 0.071
R-HSA-9824443 Parasitic Infection Pathways 0.855937 0.068
R-HSA-9658195 Leishmania infection 0.855937 0.068
R-HSA-73887 Death Receptor Signaling 0.858357 0.066
R-HSA-1266738 Developmental Biology 0.859810 0.066
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.859966 0.066
R-HSA-9612973 Autophagy 0.861556 0.065
R-HSA-9610379 HCMV Late Events 0.863129 0.064
R-HSA-162587 HIV Life Cycle 0.863129 0.064
R-HSA-5673001 RAF/MAP kinase cascade 0.865858 0.063
R-HSA-109581 Apoptosis 0.870731 0.060
R-HSA-1483257 Phospholipid metabolism 0.872885 0.059
R-HSA-5684996 MAPK1/MAPK3 signaling 0.874023 0.058
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.877913 0.057
R-HSA-5619102 SLC transporter disorders 0.877913 0.057
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.886009 0.053
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.887305 0.052
R-HSA-9664433 Leishmania parasite growth and survival 0.887305 0.052
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.888587 0.051
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.889854 0.051
R-HSA-168255 Influenza Infection 0.894781 0.048
R-HSA-3781865 Diseases of glycosylation 0.900633 0.045
R-HSA-112315 Transmission across Chemical Synapses 0.901425 0.045
R-HSA-8957322 Metabolism of steroids 0.902325 0.045
R-HSA-168898 Toll-like Receptor Cascades 0.908286 0.042
R-HSA-9675108 Nervous system development 0.912238 0.040
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.916504 0.038
R-HSA-112316 Neuronal System 0.916531 0.038
R-HSA-389948 Co-inhibition by PD-1 0.917270 0.038
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.917270 0.038
R-HSA-948021 Transport to the Golgi and subsequent modification 0.919145 0.037
R-HSA-376176 Signaling by ROBO receptors 0.920066 0.036
R-HSA-9694516 SARS-CoV-2 Infection 0.922489 0.035
R-HSA-5357801 Programmed Cell Death 0.922768 0.035
R-HSA-162906 HIV Infection 0.939992 0.027
R-HSA-913531 Interferon Signaling 0.944244 0.025
R-HSA-211859 Biological oxidations 0.947163 0.024
R-HSA-5619115 Disorders of transmembrane transporters 0.952308 0.021
R-HSA-422475 Axon guidance 0.956203 0.019
R-HSA-5688426 Deubiquitination 0.956499 0.019
R-HSA-388841 Regulation of T cell activation by CD28 family 0.956996 0.019
R-HSA-416476 G alpha (q) signalling events 0.960776 0.017
R-HSA-5668914 Diseases of metabolism 0.963458 0.016
R-HSA-76002 Platelet activation, signaling and aggregation 0.965041 0.015
R-HSA-211945 Phase I - Functionalization of compounds 0.966614 0.015
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.968117 0.014
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.972193 0.012
R-HSA-168249 Innate Immune System 0.972435 0.012
R-HSA-168256 Immune System 0.979571 0.009
R-HSA-1474244 Extracellular matrix organization 0.981884 0.008
R-HSA-199991 Membrane Trafficking 0.982367 0.008
R-HSA-1280218 Adaptive Immune System 0.983214 0.007
R-HSA-196854 Metabolism of vitamins and cofactors 0.987632 0.005
R-HSA-9679506 SARS-CoV Infections 0.989760 0.004
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.990190 0.004
R-HSA-9824439 Bacterial Infection Pathways 0.990955 0.004
R-HSA-425407 SLC-mediated transmembrane transport 0.991660 0.004
R-HSA-418594 G alpha (i) signalling events 0.992574 0.003
R-HSA-8978868 Fatty acid metabolism 0.992574 0.003
R-HSA-446203 Asparagine N-linked glycosylation 0.993762 0.003
R-HSA-388396 GPCR downstream signalling 0.994536 0.002
R-HSA-5653656 Vesicle-mediated transport 0.996054 0.002
R-HSA-372790 Signaling by GPCR 0.997547 0.001
R-HSA-556833 Metabolism of lipids 0.998636 0.001
R-HSA-597592 Post-translational protein modification 0.999024 0.000
R-HSA-109582 Hemostasis 0.999065 0.000
R-HSA-9824446 Viral Infection Pathways 0.999203 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 0.999370 0.000
R-HSA-5663205 Infectious disease 0.999765 0.000
R-HSA-1643685 Disease 0.999916 0.000
R-HSA-9709957 Sensory Perception 0.999950 0.000
R-HSA-392499 Metabolism of proteins 0.999986 0.000
R-HSA-382551 Transport of small molecules 0.999992 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.791 0.645 1 0.812
CDK18CDK18 0.783 0.659 1 0.883
HIPK2HIPK2 0.783 0.637 1 0.851
P38GP38G 0.777 0.676 1 0.915
CDK19CDK19 0.777 0.642 1 0.865
CDK3CDK3 0.776 0.581 1 0.904
CDK17CDK17 0.775 0.654 1 0.909
CDK1CDK1 0.770 0.621 1 0.870
JNK2JNK2 0.768 0.683 1 0.881
CDK8CDK8 0.768 0.634 1 0.834
CDK5CDK5 0.766 0.617 1 0.817
CDK16CDK16 0.765 0.616 1 0.897
CDK13CDK13 0.765 0.638 1 0.860
P38DP38D 0.764 0.652 1 0.901
CDK7CDK7 0.764 0.620 1 0.842
CDK12CDK12 0.763 0.639 1 0.876
ERK1ERK1 0.762 0.631 1 0.860
P38BP38B 0.761 0.646 1 0.846
DYRK2DYRK2 0.757 0.600 1 0.773
JNK3JNK3 0.757 0.663 1 0.853
CDK10CDK10 0.756 0.575 1 0.868
HIPK4HIPK4 0.756 0.468 1 0.574
HIPK1HIPK1 0.755 0.565 1 0.762
CLK3CLK3 0.755 0.400 1 0.566
CDK9CDK9 0.754 0.621 1 0.852
DYRK4DYRK4 0.754 0.601 1 0.864
P38AP38A 0.751 0.625 1 0.785
CDK14CDK14 0.749 0.599 1 0.853
DYRK1BDYRK1B 0.744 0.561 1 0.833
SRPK1SRPK1 0.743 0.291 -3 0.707
HIPK3HIPK3 0.742 0.555 1 0.728
CDK6CDK6 0.741 0.588 1 0.864
JNK1JNK1 0.740 0.591 1 0.884
CLK2CLK2 0.739 0.332 -3 0.699
NLKNLK 0.738 0.545 1 0.598
CDK4CDK4 0.735 0.596 1 0.884
ERK2ERK2 0.735 0.591 1 0.819
CDK2CDK2 0.734 0.465 1 0.758
DYRK1ADYRK1A 0.732 0.470 1 0.747
CLK1CLK1 0.730 0.334 -3 0.684
MAKMAK 0.728 0.406 -2 0.663
MTORMTOR 0.728 0.256 1 0.388
ERK5ERK5 0.726 0.309 1 0.508
SRPK2SRPK2 0.726 0.217 -3 0.629
CLK4CLK4 0.723 0.297 -3 0.713
PRP4PRP4 0.723 0.428 -3 0.800
COTCOT 0.723 0.021 2 0.791
DYRK3DYRK3 0.722 0.410 1 0.721
SRPK3SRPK3 0.715 0.192 -3 0.676
MOSMOS 0.715 0.099 1 0.279
ICKICK 0.715 0.267 -3 0.795
CDKL5CDKL5 0.713 0.124 -3 0.750
CDKL1CDKL1 0.708 0.102 -3 0.756
ERK7ERK7 0.707 0.236 2 0.570
MOKMOK 0.707 0.347 1 0.649
CDC7CDC7 0.707 -0.054 1 0.240
PRKD1PRKD1 0.706 0.078 -3 0.791
PRPKPRPK 0.703 -0.026 -1 0.752
CHAK2CHAK2 0.702 -0.002 -1 0.744
NEK6NEK6 0.702 -0.007 -2 0.746
MST4MST4 0.701 -0.026 2 0.818
DSTYKDSTYK 0.700 -0.077 2 0.840
GRK1GRK1 0.700 0.015 -2 0.697
PRKD2PRKD2 0.700 0.052 -3 0.726
SKMLCKSKMLCK 0.700 0.028 -2 0.772
PIM3PIM3 0.700 -0.036 -3 0.799
GCN2GCN2 0.699 -0.101 2 0.715
NDR2NDR2 0.699 -0.035 -3 0.799
ATRATR 0.699 -0.026 1 0.258
AURCAURC 0.699 0.029 -2 0.564
TBK1TBK1 0.699 -0.107 1 0.192
IKKBIKKB 0.699 -0.104 -2 0.636
IKKEIKKE 0.697 -0.105 1 0.191
PKCDPKCD 0.695 0.005 2 0.742
BMPR1BBMPR1B 0.695 0.006 1 0.220
RAF1RAF1 0.695 -0.140 1 0.223
PKCBPKCB 0.695 0.014 2 0.726
MLK3MLK3 0.694 0.009 2 0.727
BMPR2BMPR2 0.694 -0.094 -2 0.752
ULK2ULK2 0.694 -0.120 2 0.704
MPSK1MPSK1 0.694 0.126 1 0.283
GRK7GRK7 0.693 0.018 1 0.249
PKN3PKN3 0.693 -0.031 -3 0.782
WNK1WNK1 0.693 -0.066 -2 0.779
MLK2MLK2 0.693 -0.001 2 0.779
PKN2PKN2 0.693 -0.043 -3 0.785
IKKAIKKA 0.693 -0.051 -2 0.642
PKCAPKCA 0.692 0.023 2 0.716
TGFBR2TGFBR2 0.692 -0.067 -2 0.670
NUAK2NUAK2 0.691 -0.020 -3 0.792
NIKNIK 0.691 -0.029 -3 0.826
NDR1NDR1 0.691 -0.066 -3 0.784
MLK1MLK1 0.691 -0.108 2 0.776
CAMK1BCAMK1B 0.690 -0.046 -3 0.803
NEK7NEK7 0.690 -0.128 -3 0.805
MAPKAPK3MAPKAPK3 0.689 -0.007 -3 0.735
PDHK4PDHK4 0.689 -0.192 1 0.282
PKCGPKCG 0.688 -0.018 2 0.715
PIM1PIM1 0.688 -0.008 -3 0.740
GRK5GRK5 0.688 -0.100 -3 0.833
MAPKAPK2MAPKAPK2 0.688 0.005 -3 0.693
RSK2RSK2 0.688 -0.025 -3 0.720
GSK3AGSK3A 0.688 0.145 4 0.328
MNK2MNK2 0.688 -0.001 -2 0.681
IRE1IRE1 0.687 -0.074 1 0.204
CAMLCKCAMLCK 0.687 -0.019 -2 0.729
RSK3RSK3 0.686 -0.035 -3 0.717
PHKG1PHKG1 0.686 -0.032 -3 0.778
PKCZPKCZ 0.685 -0.019 2 0.748
NEK9NEK9 0.685 -0.096 2 0.786
MARK4MARK4 0.685 -0.056 4 0.706
PDHK1PDHK1 0.684 -0.168 1 0.257
PKACBPKACB 0.684 0.016 -2 0.575
DAPK2DAPK2 0.683 -0.037 -3 0.814
P90RSKP90RSK 0.683 -0.029 -3 0.728
RIPK3RIPK3 0.683 -0.148 3 0.598
PKACGPKACG 0.683 -0.049 -2 0.634
TGFBR1TGFBR1 0.683 -0.018 -2 0.690
CAMK2GCAMK2G 0.682 -0.126 2 0.691
MST3MST3 0.682 0.018 2 0.822
ULK1ULK1 0.681 -0.139 -3 0.780
BCKDKBCKDK 0.681 -0.132 -1 0.678
PRKD3PRKD3 0.681 0.002 -3 0.687
LATS2LATS2 0.680 -0.073 -5 0.433
PAK6PAK6 0.680 0.014 -2 0.581
CK1ECK1E 0.680 0.019 -3 0.585
CAMK2DCAMK2D 0.679 -0.066 -3 0.793
NEK2NEK2 0.679 -0.047 2 0.779
AMPKA1AMPKA1 0.679 -0.082 -3 0.807
AKT2AKT2 0.679 0.018 -3 0.637
HUNKHUNK 0.679 -0.143 2 0.729
PKRPKR 0.679 -0.060 1 0.234
YSK4YSK4 0.679 -0.076 1 0.203
ALK4ALK4 0.679 -0.040 -2 0.713
MLK4MLK4 0.678 -0.064 2 0.687
MASTLMASTL 0.678 -0.132 -2 0.689
P70S6KBP70S6KB 0.678 -0.049 -3 0.737
SGK3SGK3 0.677 -0.007 -3 0.720
PAK1PAK1 0.677 -0.044 -2 0.667
NIM1NIM1 0.677 -0.075 3 0.626
LATS1LATS1 0.677 -0.031 -3 0.808
TTBK2TTBK2 0.677 -0.134 2 0.647
MNK1MNK1 0.677 -0.026 -2 0.690
DNAPKDNAPK 0.677 -0.034 1 0.224
PINK1PINK1 0.676 0.106 1 0.425
BUB1BUB1 0.676 0.109 -5 0.475
TSSK1TSSK1 0.676 -0.047 -3 0.825
ACVR2BACVR2B 0.676 -0.051 -2 0.679
SMG1SMG1 0.676 -0.056 1 0.235
VRK2VRK2 0.676 0.041 1 0.313
DLKDLK 0.676 -0.172 1 0.231
PKG2PKG2 0.676 -0.021 -2 0.578
TAO3TAO3 0.676 0.004 1 0.249
TLK2TLK2 0.675 -0.046 1 0.191
CHAK1CHAK1 0.675 -0.102 2 0.754
ANKRD3ANKRD3 0.675 -0.143 1 0.233
TSSK2TSSK2 0.675 -0.063 -5 0.492
FAM20CFAM20C 0.675 -0.024 2 0.570
PKCHPKCH 0.675 -0.060 2 0.695
PAK3PAK3 0.675 -0.062 -2 0.659
AMPKA2AMPKA2 0.675 -0.066 -3 0.770
QSKQSK 0.674 -0.039 4 0.695
IRE2IRE2 0.674 -0.093 2 0.675
CK1DCK1D 0.673 0.039 -3 0.537
GRK6GRK6 0.673 -0.141 1 0.226
GRK4GRK4 0.673 -0.132 -2 0.723
RSK4RSK4 0.673 -0.040 -3 0.694
ACVR2AACVR2A 0.673 -0.074 -2 0.662
PRKXPRKX 0.672 -0.007 -3 0.637
ATMATM 0.672 -0.089 1 0.215
MEK1MEK1 0.671 -0.103 2 0.753
RIPK1RIPK1 0.671 -0.203 1 0.202
LKB1LKB1 0.671 0.108 -3 0.809
PKCTPKCT 0.671 -0.038 2 0.699
AURBAURB 0.671 -0.036 -2 0.554
NEK5NEK5 0.670 -0.027 1 0.208
CAMK2ACAMK2A 0.669 -0.044 2 0.690
TNIKTNIK 0.669 0.060 3 0.786
WNK3WNK3 0.669 -0.257 1 0.210
MEKK2MEKK2 0.669 -0.064 2 0.742
PIM2PIM2 0.668 -0.020 -3 0.692
QIKQIK 0.668 -0.116 -3 0.783
MEKK1MEKK1 0.668 -0.088 1 0.219
GRK2GRK2 0.667 -0.070 -2 0.634
SIKSIK 0.667 -0.054 -3 0.708
PKCEPKCE 0.667 -0.009 2 0.713
ALK2ALK2 0.667 -0.075 -2 0.692
NUAK1NUAK1 0.667 -0.078 -3 0.726
ZAKZAK 0.666 -0.108 1 0.204
PKCIPKCI 0.666 -0.035 2 0.719
MSK2MSK2 0.666 -0.067 -3 0.707
CK1A2CK1A2 0.666 0.013 -3 0.535
GCKGCK 0.666 0.000 1 0.240
PLK4PLK4 0.666 -0.106 2 0.503
BMPR1ABMPR1A 0.666 -0.058 1 0.207
MARK3MARK3 0.666 -0.048 4 0.644
MEK5MEK5 0.665 -0.121 2 0.754
GSK3BGSK3B 0.665 0.016 4 0.324
CK1G1CK1G1 0.665 -0.021 -3 0.561
DCAMKL1DCAMKL1 0.665 -0.043 -3 0.738
NEK11NEK11 0.665 -0.069 1 0.243
AKT1AKT1 0.665 -0.009 -3 0.658
DRAK1DRAK1 0.665 -0.121 1 0.209
HPK1HPK1 0.665 -0.002 1 0.241
PERKPERK 0.665 -0.105 -2 0.702
MELKMELK 0.664 -0.093 -3 0.747
CAMK2BCAMK2B 0.664 -0.086 2 0.667
KHS1KHS1 0.664 0.041 1 0.222
HGKHGK 0.663 0.006 3 0.777
MAP3K15MAP3K15 0.663 -0.003 1 0.212
HASPINHASPIN 0.663 0.044 -1 0.654
CAMK4CAMK4 0.663 -0.143 -3 0.764
MSK1MSK1 0.662 -0.051 -3 0.708
KHS2KHS2 0.662 0.027 1 0.241
PLK1PLK1 0.662 -0.161 -2 0.660
IRAK4IRAK4 0.662 -0.109 1 0.184
MYLK4MYLK4 0.662 -0.069 -2 0.663
AKT3AKT3 0.662 0.020 -3 0.588
MEKK6MEKK6 0.662 -0.023 1 0.216
PKACAPKACA 0.661 -0.017 -2 0.537
GAKGAK 0.661 -0.036 1 0.290
MEKK3MEKK3 0.661 -0.167 1 0.223
PDK1PDK1 0.660 -0.026 1 0.245
PASKPASK 0.660 -0.056 -3 0.821
BRSK1BRSK1 0.660 -0.081 -3 0.739
MAPKAPK5MAPKAPK5 0.660 -0.079 -3 0.678
TAO2TAO2 0.660 -0.039 2 0.798
AURAAURA 0.660 -0.057 -2 0.533
PAK2PAK2 0.659 -0.099 -2 0.641
BRSK2BRSK2 0.659 -0.104 -3 0.759
WNK4WNK4 0.659 -0.134 -2 0.768
MINKMINK 0.659 -0.043 1 0.207
PAK5PAK5 0.659 -0.034 -2 0.519
CHK1CHK1 0.658 -0.095 -3 0.786
MARK2MARK2 0.658 -0.078 4 0.613
TLK1TLK1 0.658 -0.104 -2 0.730
BRAFBRAF 0.658 -0.096 -4 0.756
NEK4NEK4 0.658 -0.055 1 0.198
PBKPBK 0.658 0.011 1 0.259
LOKLOK 0.657 -0.014 -2 0.643
HRIHRI 0.657 -0.158 -2 0.717
MST2MST2 0.657 -0.054 1 0.216
PAK4PAK4 0.657 -0.019 -2 0.528
PHKG2PHKG2 0.655 -0.107 -3 0.729
NEK8NEK8 0.655 -0.115 2 0.765
GRK3GRK3 0.654 -0.076 -2 0.605
PKN1PKN1 0.654 -0.039 -3 0.670
SSTKSSTK 0.654 -0.061 4 0.679
CAMKK2CAMKK2 0.654 -0.047 -2 0.631
DCAMKL2DCAMKL2 0.654 -0.072 -3 0.748
SLKSLK 0.654 -0.035 -2 0.599
CAMK1GCAMK1G 0.653 -0.095 -3 0.697
NEK1NEK1 0.652 -0.030 1 0.191
CK2A2CK2A2 0.652 -0.069 1 0.205
SGK1SGK1 0.652 0.005 -3 0.568
PLK3PLK3 0.652 -0.142 2 0.652
CAMKK1CAMKK1 0.652 -0.113 -2 0.630
EEF2KEEF2K 0.651 -0.062 3 0.720
LRRK2LRRK2 0.650 -0.032 2 0.783
YSK1YSK1 0.650 -0.047 2 0.781
SNRKSNRK 0.650 -0.174 2 0.575
SBKSBK 0.650 0.077 -3 0.522
MARK1MARK1 0.649 -0.110 4 0.657
SMMLCKSMMLCK 0.649 -0.085 -3 0.756
OSR1OSR1 0.648 0.001 2 0.743
ROCK2ROCK2 0.648 -0.022 -3 0.740
TAK1TAK1 0.647 -0.100 1 0.204
MST1MST1 0.647 -0.066 1 0.205
P70S6KP70S6K 0.645 -0.082 -3 0.651
MYO3BMYO3B 0.644 0.010 2 0.794
AAK1AAK1 0.644 0.032 1 0.273
MRCKBMRCKB 0.644 -0.035 -3 0.677
CHK2CHK2 0.644 -0.034 -3 0.585
DAPK3DAPK3 0.644 -0.065 -3 0.746
CK2A1CK2A1 0.643 -0.077 1 0.199
NEK3NEK3 0.643 -0.065 1 0.204
BIKEBIKE 0.642 -0.007 1 0.274
TTBK1TTBK1 0.642 -0.170 2 0.554
CK1ACK1A 0.641 0.005 -3 0.451
STK33STK33 0.640 -0.112 2 0.536
VRK1VRK1 0.640 -0.140 2 0.748
PDHK3_TYRPDHK3_TYR 0.639 0.140 4 0.751
LIMK2_TYRLIMK2_TYR 0.638 0.158 -3 0.843
CAMK1DCAMK1D 0.638 -0.070 -3 0.631
TAO1TAO1 0.637 -0.045 1 0.203
DAPK1DAPK1 0.637 -0.074 -3 0.730
IRAK1IRAK1 0.636 -0.234 -1 0.652
ASK1ASK1 0.636 -0.033 1 0.211
DMPK1DMPK1 0.635 -0.022 -3 0.697
MYO3AMYO3A 0.635 -0.044 1 0.220
TESK1_TYRTESK1_TYR 0.635 0.097 3 0.760
CAMK1ACAMK1A 0.634 -0.037 -3 0.599
PKMYT1_TYRPKMYT1_TYR 0.634 0.113 3 0.730
MEK2MEK2 0.634 -0.146 2 0.726
MAP2K4_TYRMAP2K4_TYR 0.633 0.105 -1 0.761
PLK2PLK2 0.633 -0.081 -3 0.778
TTKTTK 0.633 -0.069 -2 0.687
PDHK4_TYRPDHK4_TYR 0.632 0.057 2 0.782
MRCKAMRCKA 0.631 -0.077 -3 0.694
CRIKCRIK 0.631 -0.031 -3 0.663
ROCK1ROCK1 0.630 -0.047 -3 0.696
MAP2K6_TYRMAP2K6_TYR 0.630 0.055 -1 0.776
BMPR2_TYRBMPR2_TYR 0.630 0.052 -1 0.801
PKG1PKG1 0.629 -0.062 -2 0.497
PDHK1_TYRPDHK1_TYR 0.626 0.002 -1 0.775
MAP2K7_TYRMAP2K7_TYR 0.624 -0.058 2 0.768
ABL2ABL2 0.623 0.026 -1 0.669
RIPK2RIPK2 0.623 -0.236 1 0.184
YANK3YANK3 0.623 -0.059 2 0.332
TXKTXK 0.622 0.005 1 0.215
PINK1_TYRPINK1_TYR 0.622 -0.104 1 0.272
CSF1RCSF1R 0.622 -0.007 3 0.695
LIMK1_TYRLIMK1_TYR 0.620 -0.011 2 0.778
JAK2JAK2 0.620 -0.017 1 0.229
EPHA6EPHA6 0.620 -0.014 -1 0.742
LCKLCK 0.620 0.003 -1 0.740
RETRET 0.619 -0.066 1 0.226
ABL1ABL1 0.619 0.009 -1 0.660
ALPHAK3ALPHAK3 0.618 -0.090 -1 0.668
BLKBLK 0.617 -0.012 -1 0.738
MST1RMST1R 0.617 -0.053 3 0.711
JAK1JAK1 0.616 -0.023 1 0.198
TNNI3K_TYRTNNI3K_TYR 0.616 0.012 1 0.233
EPHB4EPHB4 0.614 -0.031 -1 0.672
NEK10_TYRNEK10_TYR 0.614 -0.055 1 0.205
FGRFGR 0.614 -0.081 1 0.219
ROS1ROS1 0.614 -0.085 3 0.656
TYK2TYK2 0.613 -0.140 1 0.210
TYRO3TYRO3 0.613 -0.093 3 0.696
STLK3STLK3 0.612 -0.133 1 0.186
JAK3JAK3 0.612 -0.077 1 0.216
HCKHCK 0.612 -0.061 -1 0.723
TNK2TNK2 0.612 -0.048 3 0.652
METMET 0.610 -0.029 3 0.693
TNK1TNK1 0.610 -0.032 3 0.680
YES1YES1 0.610 -0.082 -1 0.708
KDRKDR 0.609 -0.051 3 0.640
ITKITK 0.609 -0.084 -1 0.680
KITKIT 0.608 -0.067 3 0.688
FYNFYN 0.607 -0.021 -1 0.738
FGFR2FGFR2 0.603 -0.066 3 0.653
ZAP70ZAP70 0.602 0.030 -1 0.651
EPHA4EPHA4 0.602 -0.058 2 0.666
FERFER 0.601 -0.151 1 0.223
SRMSSRMS 0.601 -0.112 1 0.201
BMXBMX 0.601 -0.075 -1 0.604
INSRRINSRR 0.601 -0.135 3 0.613
CK1G3CK1G3 0.600 -0.043 -3 0.404
MERTKMERTK 0.600 -0.091 3 0.665
DDR1DDR1 0.600 -0.160 4 0.661
WEE1_TYRWEE1_TYR 0.599 -0.085 -1 0.624
TEKTEK 0.599 -0.051 3 0.616
FLT1FLT1 0.599 -0.079 -1 0.713
FGFR1FGFR1 0.599 -0.071 3 0.635
PTK2PTK2 0.598 0.004 -1 0.745
EPHB3EPHB3 0.598 -0.092 -1 0.653
FLT3FLT3 0.598 -0.164 3 0.700
PDGFRBPDGFRB 0.597 -0.175 3 0.691
EPHB2EPHB2 0.597 -0.088 -1 0.646
EPHB1EPHB1 0.597 -0.135 1 0.198
FRKFRK 0.596 -0.086 -1 0.712
CK1G2CK1G2 0.596 -0.034 -3 0.487
SYKSYK 0.596 -0.012 -1 0.704
AXLAXL 0.595 -0.130 3 0.654
FGFR3FGFR3 0.594 -0.072 3 0.622
LYNLYN 0.594 -0.089 3 0.604
YANK2YANK2 0.594 -0.071 2 0.352
SRCSRC 0.593 -0.074 -1 0.703
ERBB2ERBB2 0.592 -0.121 1 0.204
EPHA1EPHA1 0.592 -0.090 3 0.677
MATKMATK 0.592 -0.073 -1 0.598
TECTEC 0.592 -0.133 -1 0.584
PDGFRAPDGFRA 0.591 -0.181 3 0.699
EPHA7EPHA7 0.591 -0.089 2 0.669
EGFREGFR 0.591 -0.079 1 0.171
BTKBTK 0.590 -0.190 -1 0.629
PTK2BPTK2B 0.590 -0.066 -1 0.623
EPHA8EPHA8 0.590 -0.060 -1 0.679
ALKALK 0.589 -0.138 3 0.602
NTRK3NTRK3 0.589 -0.099 -1 0.609
DDR2DDR2 0.587 -0.073 3 0.596
ERBB4ERBB4 0.586 -0.051 1 0.182
EPHA3EPHA3 0.585 -0.107 2 0.633
FGFR4FGFR4 0.585 -0.075 -1 0.613
INSRINSR 0.584 -0.160 3 0.600
PTK6PTK6 0.584 -0.162 -1 0.587
CSKCSK 0.583 -0.112 2 0.667
FLT4FLT4 0.583 -0.163 3 0.617
LTKLTK 0.583 -0.159 3 0.621
MUSKMUSK 0.583 -0.103 1 0.159
NTRK1NTRK1 0.582 -0.192 -1 0.653
NTRK2NTRK2 0.580 -0.200 3 0.629
EPHA5EPHA5 0.579 -0.117 2 0.641
EPHA2EPHA2 0.578 -0.077 -1 0.642
IGF1RIGF1R 0.570 -0.138 3 0.534
FESFES 0.558 -0.143 -1 0.570