Motif 256 (n=216)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2692 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0G2JLL6 | None | S208 | ochoa | Proline-rich transmembrane protein 2 | None |
| A1X283 | SH3PXD2B | S649 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A1X283 | SH3PXD2B | S770 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A8MQ03 | CYSRT1 | S92 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| H0Y626 | None | S24 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O00512 | BCL9 | S904 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14497 | ARID1A | S772 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14545 | TRAFD1 | S489 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14640 | DVL1 | S676 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14641 | DVL2 | S717 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14686 | KMT2D | S4359 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15027 | SEC16A | S2183 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15231 | ZNF185 | S453 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O15231 | ZNF185 | S519 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O15357 | INPPL1 | S158 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15446 | POLR1G | S27 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O60244 | MED14 | S1144 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60346 | PHLPP1 | S412 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60828 | PQBP1 | S218 | ochoa | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:21933836, ECO:0000269|PubMed:23512658, ECO:0000269|PubMed:26046437}. |
| O60885 | BRD4 | S1051 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75064 | DENND4B | S1092 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75145 | PPFIA3 | S537 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75369 | FLNB | S846 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1545 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94850 | DDN | S567 | ochoa | Dendrin | Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). {ECO:0000250}. |
| O94855 | SEC24D | S22 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94855 | SEC24D | S266 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94967 | WDR47 | S558 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95361 | TRIM16 | S24 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95714 | HERC2 | S1601 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95785 | WIZ | S1012 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P0C1Z6 | TFPT | S188 | ochoa | TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) | Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| P10070 | GLI2 | S92 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P10636 | MAPT | S444 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11274 | BCR | S122 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P15407 | FOSL1 | S101 | ochoa | Fos-related antigen 1 (FRA-1) | None |
| P21333 | FLNA | S972 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S1256 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22736 | NR4A1 | S199 | ochoa | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P27695 | APEX1 | S54 | ochoa | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
| P27987 | ITPKB | S71 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P28715 | ERCC5 | S532 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29590 | PML | S40 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30101 | PDIA3 | S456 | ochoa | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| P32519 | ELF1 | S187 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P41162 | ETV3 | S159 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P42684 | ABL2 | S1054 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46109 | CRKL | S222 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P46379 | BAG6 | S218 | psp | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P46821 | MAP1B | S25 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S1525 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49674 | CSNK1E | S363 | ochoa | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P51532 | SMARCA4 | S35 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P52746 | ZNF142 | S1011 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P53814 | SMTN | S251 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P53992 | SEC24C | S328 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P54646 | PRKAA2 | S377 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P54792 | DVL1P1 | S651 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P55201 | BRPF1 | S926 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P78559 | MAP1A | S2427 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00613 | HSF1 | S320 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q02086 | SP2 | S188 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q07889 | SOS1 | S1265 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q09666 | AHNAK | S658 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S978 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13112 | CHAF1B | S464 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13136 | PPFIA1 | S700 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13177 | PAK2 | S192 | ochoa|psp | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13275 | SEMA3F | S766 | ochoa | Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV) | May play a role in cell motility and cell adhesion. |
| Q13428 | TCOF1 | S1228 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | S290 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13480 | GAB1 | S355 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13886 | KLF9 | S122 | ochoa | Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1) | Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835). {ECO:0000269|PubMed:22711835}. |
| Q14160 | SCRIB | S1348 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14160 | SCRIB | S1561 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14194 | CRMP1 | S522 | ochoa|psp | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q14315 | FLNC | S868 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1156 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1251 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1540 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14934 | NFATC4 | S819 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14980 | NUMA1 | S1757 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14CZ8 | HEPACAM | S384 | ochoa | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205). {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256, ECO:0000269|PubMed:22405205}. |
| Q15642 | TRIP10 | S351 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q15678 | PTPN14 | S760 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15744 | CEBPE | S109 | ochoa | CCAAT/enhancer-binding protein epsilon (C/EBP epsilon) | Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269|PubMed:10359588, ECO:0000269|PubMed:26019275}. |
| Q15772 | SPEG | S2004 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15942 | ZYX | S267 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16584 | MAP3K11 | S758 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16584 | MAP3K11 | S765 | ochoa | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16643 | DBN1 | S416 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q2KHR2 | RFX7 | S424 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
| Q2KJY2 | KIF26B | S1786 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q3KQU3 | MAP7D1 | S399 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3T8J9 | GON4L | S206 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q5JRA6 | MIA3 | S1691 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5JTC6 | AMER1 | S246 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5M775 | SPECC1 | S863 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0W9 | FAM83B | S875 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T4S7 | UBR4 | S620 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T7N3 | KANK4 | S636 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5TKA1 | LIN9 | S321 | ochoa|psp | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VY43 | PEAR1 | S964 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q69YQ0 | SPECC1L | S881 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6P1N0 | CC2D1A | S468 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6PJG2 | MIDEAS | S346 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6WKZ4 | RAB11FIP1 | S545 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZN55 | ZNF574 | S723 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZRS2 | SRCAP | S2869 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZU65 | UBN2 | S1060 | ochoa | Ubinuclein-2 | None |
| Q6ZVL6 | KIAA1549L | S1653 | ochoa | UPF0606 protein KIAA1549L | None |
| Q765P7 | MTSS2 | S601 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q76L83 | ASXL2 | S648 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7RTP6 | MICAL3 | S1156 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2K8 | GPRIN1 | S970 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z4K8 | TRIM46 | S85 | ochoa | Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}. |
| Q7Z6L0 | PRRT2 | S208 | ochoa | Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) | As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation. {ECO:0000250|UniProtKB:E9PUL5}. |
| Q86TB9 | PATL1 | S291 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86UE8 | TLK2 | S111 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UU0 | BCL9L | S1010 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86WB0 | ZC3HC1 | S321 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86XJ1 | GAS2L3 | S431 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86XN7 | PROSER1 | S287 | ochoa | Proline and serine-rich protein 1 | Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). {ECO:0000269|PubMed:34667079}. |
| Q8IV56 | PRR15 | S49 | ochoa | Proline-rich protein 15 | May have a role in proliferation and/or differentiation. {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S512 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXT5 | RBM12B | S874 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IY18 | SMC5 | S26 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8IY92 | SLX4 | S1044 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYB3 | SRRM1 | S414 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZW8 | TNS4 | S228 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8IZW8 | TNS4 | S350 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N1G0 | ZNF687 | S266 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1G0 | ZNF687 | S1191 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N2G6 | ZCCHC24 | S65 | ochoa | Zinc finger CCHC domain-containing protein 24 | None |
| Q8N344 | MIER2 | S467 | ochoa | Mesoderm induction early response protein 2 (Mi-er2) | Transcriptional repressor. {ECO:0000250}. |
| Q8N3V7 | SYNPO | S870 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4C8 | MINK1 | S631 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N5Y2 | MSL3 | S347 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
| Q8N612 | FHIP1B | S529 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NC74 | RBBP8NL | S196 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NCV1 | ADAD2 | S201 | ochoa | Adenosine deaminase domain-containing protein 2 (Testis nuclear RNA-binding protein-like) | Required for male fertility and normal male germ cell differentiation. {ECO:0000250|UniProtKB:Q9D5P4}. |
| Q8NDX1 | PSD4 | S461 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEY1 | NAV1 | S541 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHM5 | KDM2B | S1031 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TC05 | MDM1 | S637 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TC26 | TMEM163 | S38 | ochoa | Transmembrane protein 163 | Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}. |
| Q8TES7 | FBF1 | S334 | ochoa|psp | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8WWN8 | ARAP3 | S1480 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q8WXE0 | CASKIN2 | S393 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WYL5 | SSH1 | S689 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92547 | TOPBP1 | S864 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92585 | MAML1 | S932 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92766 | RREB1 | S1135 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92841 | DDX17 | S64 | ochoa | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) | As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:22266867, PubMed:23022728, PubMed:24910439). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:22266867, PubMed:26209609). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:19995069, PubMed:20663877). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:19995069, PubMed:20406972, PubMed:20663877, PubMed:24275493). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). {ECO:0000250|UniProtKB:Q501J6, ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17485482, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:18334637, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:20406972, ECO:0000269|PubMed:20663877, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:24275493, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:24910439, ECO:0000269|PubMed:25126784, ECO:0000269|PubMed:26209609, ECO:0000269|PubMed:27478153, ECO:0000305}. |
| Q92997 | DVL3 | S697 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96B36 | AKT1S1 | S92 | ochoa | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
| Q96BD0 | SLCO4A1 | S40 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96KQ7 | EHMT2 | S173 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96L91 | EP400 | S2686 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96MS0 | ROBO3 | S1186 | ochoa | Roundabout homolog 3 (Roundabout-like protein 3) | Receptor involved in axon guidance during development (PubMed:15105459). Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (By similarity). {ECO:0000250|UniProtKB:Q9Z2I4, ECO:0000269|PubMed:15105459}. |
| Q96MX3 | ZNF48 | S416 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q96MY1 | NOL4L | S400 | ochoa | Nucleolar protein 4-like | None |
| Q96NA8 | TSNARE1 | S96 | ochoa | t-SNARE domain-containing protein 1 | None |
| Q96QT6 | PHF12 | S555 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96S59 | RANBP9 | S176 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96T17 | MAP7D2 | S219 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96T58 | SPEN | S3487 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99700 | ATXN2 | S728 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99708 | RBBP8 | S568 | ochoa | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99958 | FOXC2 | S367 | psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQI5 | SGIP1 | S372 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BRQ0 | PYGO2 | S277 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| Q9BTX1 | NDC1 | S487 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BVG9 | PTDSS2 | S24 | ochoa | Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:Q9Z1X2, ECO:0000269|PubMed:19014349}. |
| Q9BVR0 | HERC2P3 | S328 | ochoa | Putative HERC2-like protein 3 | None |
| Q9BVT8 | TMUB1 | S98 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}. |
| Q9BW04 | SARG | S429 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BZ72 | PITPNM2 | S894 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9C009 | FOXQ1 | S248 | ochoa | Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) | Plays a role in hair follicle differentiation. {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S1516 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1K0 | RBSN | S601 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H6F5 | CCDC86 | S188 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6J7 | CSTPP1 | S304 | ochoa | Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly (PubMed:34782749). Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding (PubMed:34782749). {ECO:0000269|PubMed:34782749}. |
| Q9H6K5 | PRR36 | S110 | ochoa | Proline-rich protein 36 | None |
| Q9H6S3 | EPS8L2 | S449 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H6Y7 | RNF167 | S314 | ochoa | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) | E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617, ECO:0000269|PubMed:23353890, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:32409562, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:33650289, ECO:0000269|PubMed:35114100}. |
| Q9H792 | PEAK1 | S572 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H792 | PEAK1 | S878 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H910 | JPT2 | S69 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCC9 | ZFYVE28 | S384 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NWH9 | SLTM | S882 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9P1Y5 | CAMSAP3 | S560 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9UBW5 | BIN2 | S425 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UIF9 | BAZ2A | S1207 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKV3 | ACIN1 | S698 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UL51 | HCN2 | S786 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULJ3 | ZBTB21 | S1003 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULM3 | YEATS2 | S367 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULP9 | TBC1D24 | S468 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9UM47 | NOTCH3 | S2203 | ochoa | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}. |
| Q9UM54 | MYO6 | S1155 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9UMN6 | KMT2B | S1936 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPN4 | CEP131 | S417 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPT8 | ZC3H4 | S1114 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S2335 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB8 | BAIAP2 | S484 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y4B5 | MTCL1 | S1730 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S1237 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S1283 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5Y5 | PEX16 | S158 | ochoa | Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) | Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}. |
| Q9Y6R0 | NUMBL | T409 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| R4GMW8 | BIVM-ERCC5 | S986 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q07157 | TJP1 | S1188 | Sugiyama | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q8TD08 | MAPK15 | S442 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q96PY6 | NEK1 | S439 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.000051 | 4.291 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.000027 | 4.574 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.000136 | 3.867 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000346 | 3.460 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000400 | 3.398 |
| R-HSA-195721 | Signaling by WNT | 0.000543 | 3.266 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000909 | 3.041 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.001218 | 2.914 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.001509 | 2.821 |
| R-HSA-4839726 | Chromatin organization | 0.001431 | 2.844 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.002437 | 2.613 |
| R-HSA-9664420 | Killing mechanisms | 0.002814 | 2.551 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.002814 | 2.551 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.002437 | 2.613 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.002430 | 2.614 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005631 | 2.249 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.007126 | 2.147 |
| R-HSA-75153 | Apoptotic execution phase | 0.006986 | 2.156 |
| R-HSA-6806834 | Signaling by MET | 0.007891 | 2.103 |
| R-HSA-112412 | SOS-mediated signalling | 0.008641 | 2.063 |
| R-HSA-8875656 | MET receptor recycling | 0.010362 | 1.985 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.013692 | 1.864 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.014215 | 1.847 |
| R-HSA-74749 | Signal attenuation | 0.014215 | 1.847 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.012221 | 1.913 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.014215 | 1.847 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.015031 | 1.823 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.016121 | 1.793 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.027198 | 1.565 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 0.040519 | 1.392 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.053659 | 1.270 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.066619 | 1.176 |
| R-HSA-8865999 | MET activates PTPN11 | 0.066619 | 1.176 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.066619 | 1.176 |
| R-HSA-1296061 | HCN channels | 0.079403 | 1.100 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.079403 | 1.100 |
| R-HSA-74713 | IRS activation | 0.092013 | 1.036 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.092013 | 1.036 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.018588 | 1.731 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.020961 | 1.679 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.104450 | 0.981 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.104450 | 0.981 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.116718 | 0.933 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.128819 | 0.890 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.128819 | 0.890 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.128819 | 0.890 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.128819 | 0.890 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.140754 | 0.852 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.047235 | 1.326 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.164140 | 0.785 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.175593 | 0.755 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.175593 | 0.755 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.175593 | 0.755 |
| R-HSA-4641258 | Degradation of DVL | 0.023581 | 1.627 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.186891 | 0.728 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.198034 | 0.703 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.198034 | 0.703 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.198034 | 0.703 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.198034 | 0.703 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.198034 | 0.703 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.198034 | 0.703 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.198034 | 0.703 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.080710 | 1.093 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.209026 | 0.680 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.084782 | 1.072 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.230561 | 0.637 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.251512 | 0.599 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.251512 | 0.599 |
| R-HSA-180292 | GAB1 signalosome | 0.271895 | 0.566 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.271895 | 0.566 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.281879 | 0.550 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.281879 | 0.550 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.281879 | 0.550 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.291726 | 0.535 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.291726 | 0.535 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.291726 | 0.535 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.291726 | 0.535 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.291726 | 0.535 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.291726 | 0.535 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.311019 | 0.507 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.311019 | 0.507 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.320468 | 0.494 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.320468 | 0.494 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.195904 | 0.708 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.151082 | 0.821 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.241202 | 0.618 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.256434 | 0.591 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.256434 | 0.591 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.271682 | 0.566 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.307183 | 0.513 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.307183 | 0.513 |
| R-HSA-380287 | Centrosome maturation | 0.317275 | 0.499 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.215932 | 0.666 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.125941 | 0.900 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.271895 | 0.566 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.088915 | 1.051 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.301439 | 0.521 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.157603 | 0.802 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.304320 | 0.517 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.304320 | 0.517 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.241108 | 0.618 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.304320 | 0.517 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.152527 | 0.817 |
| R-HSA-198203 | PI3K/AKT activation | 0.164140 | 0.785 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.241108 | 0.618 |
| R-HSA-3371556 | Cellular response to heat stress | 0.285642 | 0.544 |
| R-HSA-5693538 | Homology Directed Repair | 0.111115 | 0.954 |
| R-HSA-191650 | Regulation of gap junction activity | 0.079403 | 1.100 |
| R-HSA-428540 | Activation of RAC1 | 0.018588 | 1.731 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.104450 | 0.981 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.152527 | 0.817 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.198034 | 0.703 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.251512 | 0.599 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.098048 | 1.009 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.198034 | 0.703 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.166377 | 0.779 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.297062 | 0.527 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.106011 | 0.975 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.094222 | 1.026 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.101657 | 0.993 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.101657 | 0.993 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.151931 | 0.818 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.185982 | 0.731 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.263369 | 0.579 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.091218 | 1.040 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.019654 | 1.707 |
| R-HSA-4086400 | PCP/CE pathway | 0.032123 | 1.493 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.092013 | 1.036 |
| R-HSA-8851805 | MET activates RAS signaling | 0.020961 | 1.679 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.026059 | 1.584 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.028777 | 1.541 |
| R-HSA-9613354 | Lipophagy | 0.152527 | 0.817 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.030997 | 1.509 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.219867 | 0.658 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.078534 | 1.105 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.322309 | 0.492 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.086225 | 1.064 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.241202 | 0.618 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.241202 | 0.618 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.241202 | 0.618 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.241202 | 0.618 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.297062 | 0.527 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.183732 | 0.736 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.291994 | 0.535 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.097355 | 1.012 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.110414 | 0.957 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.211719 | 0.674 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.066619 | 1.176 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.079403 | 1.100 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.092013 | 1.036 |
| R-HSA-1483101 | Synthesis of PS | 0.104450 | 0.981 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.040695 | 1.390 |
| R-HSA-190873 | Gap junction degradation | 0.152527 | 0.817 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.164140 | 0.785 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.175593 | 0.755 |
| R-HSA-4839744 | Signaling by APC mutants | 0.175593 | 0.755 |
| R-HSA-8875878 | MET promotes cell motility | 0.024977 | 1.602 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.186891 | 0.728 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.186891 | 0.728 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.068885 | 1.162 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.068885 | 1.162 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.209026 | 0.680 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.209026 | 0.680 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.230561 | 0.637 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.230561 | 0.637 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.241108 | 0.618 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.110414 | 0.957 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.251512 | 0.599 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.071162 | 1.148 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.301439 | 0.521 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.311019 | 0.507 |
| R-HSA-157118 | Signaling by NOTCH | 0.289933 | 0.538 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.084782 | 1.072 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.088915 | 1.051 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.114864 | 0.940 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.078534 | 1.105 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.040695 | 1.390 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.021713 | 1.663 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.114864 | 0.940 |
| R-HSA-112399 | IRS-mediated signalling | 0.061851 | 1.209 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.167543 | 0.776 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.140754 | 0.852 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.110414 | 0.957 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.261774 | 0.582 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.291726 | 0.535 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.081063 | 1.091 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.084782 | 1.072 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.164140 | 0.785 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.057702 | 1.239 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.198034 | 0.703 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.128480 | 0.891 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.271895 | 0.566 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.236133 | 0.627 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.037565 | 1.425 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.037565 | 1.425 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.194778 | 0.710 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.088731 | 1.052 |
| R-HSA-165159 | MTOR signalling | 0.151931 | 0.818 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.088857 | 1.051 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.105337 | 0.977 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.095944 | 1.018 |
| R-HSA-177929 | Signaling by EGFR | 0.059618 | 1.225 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.092013 | 1.036 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.026059 | 1.584 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.026059 | 1.584 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.034533 | 1.462 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.050640 | 1.296 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.164140 | 0.785 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.020919 | 1.679 |
| R-HSA-1483226 | Synthesis of PI | 0.175593 | 0.755 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.061353 | 1.212 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.065082 | 1.187 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.186891 | 0.728 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.072759 | 1.138 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.088915 | 1.051 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.241202 | 0.618 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.322309 | 0.492 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.050640 | 1.296 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.050640 | 1.296 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.162307 | 0.790 |
| R-HSA-8853659 | RET signaling | 0.022228 | 1.653 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.198034 | 0.703 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.230561 | 0.637 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.230561 | 0.637 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.101657 | 0.993 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.114864 | 0.940 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.281879 | 0.550 |
| R-HSA-73894 | DNA Repair | 0.272097 | 0.565 |
| R-HSA-3928664 | Ephrin signaling | 0.271895 | 0.566 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.171244 | 0.766 |
| R-HSA-5689603 | UCH proteinases | 0.322309 | 0.492 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.156718 | 0.805 |
| R-HSA-3214847 | HATs acetylate histones | 0.067079 | 1.173 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.166377 | 0.779 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.092013 | 1.036 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.128819 | 0.890 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.152527 | 0.817 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.054129 | 1.267 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.072759 | 1.138 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.198034 | 0.703 |
| R-HSA-186763 | Downstream signal transduction | 0.093107 | 1.031 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.241108 | 0.618 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.311019 | 0.507 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.105337 | 0.977 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.320468 | 0.494 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.076701 | 1.115 |
| R-HSA-170968 | Frs2-mediated activation | 0.209026 | 0.680 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.220969 | 0.656 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.029427 | 1.531 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.281879 | 0.550 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.311019 | 0.507 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.320468 | 0.494 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.036120 | 1.442 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.205408 | 0.687 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.185982 | 0.731 |
| R-HSA-199991 | Membrane Trafficking | 0.081213 | 1.090 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.147855 | 0.830 |
| R-HSA-164944 | Nef and signal transduction | 0.116718 | 0.933 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.198034 | 0.703 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.198034 | 0.703 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.198034 | 0.703 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.101657 | 0.993 |
| R-HSA-167044 | Signalling to RAS | 0.301439 | 0.521 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.323052 | 0.491 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.260775 | 0.584 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.241202 | 0.618 |
| R-HSA-422475 | Axon guidance | 0.161323 | 0.792 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.050788 | 1.294 |
| R-HSA-9675108 | Nervous system development | 0.131690 | 0.880 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.026417 | 1.578 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.320468 | 0.494 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.190934 | 0.719 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.255679 | 0.592 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.205408 | 0.687 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.166377 | 0.779 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.031603 | 1.500 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.209026 | 0.680 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.219867 | 0.658 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.101657 | 0.993 |
| R-HSA-109704 | PI3K Cascade | 0.190934 | 0.719 |
| R-HSA-162582 | Signal Transduction | 0.134711 | 0.871 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.076701 | 1.115 |
| R-HSA-169893 | Prolonged ERK activation events | 0.241108 | 0.618 |
| R-HSA-187687 | Signalling to ERKs | 0.114864 | 0.940 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.244986 | 0.611 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.312233 | 0.506 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.209026 | 0.680 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.073584 | 1.133 |
| R-HSA-9675135 | Diseases of DNA repair | 0.171244 | 0.766 |
| R-HSA-373755 | Semaphorin interactions | 0.256434 | 0.591 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.023629 | 1.627 |
| R-HSA-210993 | Tie2 Signaling | 0.271895 | 0.566 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.220969 | 0.656 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.111115 | 0.954 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.161534 | 0.792 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.212496 | 0.673 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.291994 | 0.535 |
| R-HSA-186797 | Signaling by PDGF | 0.251353 | 0.600 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.219867 | 0.658 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.241108 | 0.618 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.317275 | 0.499 |
| R-HSA-69481 | G2/M Checkpoints | 0.311809 | 0.506 |
| R-HSA-2559583 | Cellular Senescence | 0.295155 | 0.530 |
| R-HSA-166520 | Signaling by NTRKs | 0.081385 | 1.089 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.152527 | 0.817 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.061353 | 1.212 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.198034 | 0.703 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.329788 | 0.482 |
| R-HSA-74160 | Gene expression (Transcription) | 0.329214 | 0.483 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.136940 | 0.863 |
| R-HSA-2586552 | Signaling by Leptin | 0.164140 | 0.785 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.032611 | 1.487 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.311019 | 0.507 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.140754 | 0.852 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.152527 | 0.817 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.186891 | 0.728 |
| R-HSA-9842663 | Signaling by LTK | 0.198034 | 0.703 |
| R-HSA-200425 | Carnitine shuttle | 0.329788 | 0.482 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.241202 | 0.618 |
| R-HSA-877300 | Interferon gamma signaling | 0.229056 | 0.640 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.273783 | 0.563 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.273783 | 0.563 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.241108 | 0.618 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.271895 | 0.566 |
| R-HSA-109581 | Apoptosis | 0.237857 | 0.624 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.068885 | 1.162 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.072759 | 1.138 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.320468 | 0.494 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.144651 | 0.840 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.038116 | 1.419 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.088915 | 1.051 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.320468 | 0.494 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.329788 | 0.482 |
| R-HSA-9607240 | FLT3 Signaling | 0.142448 | 0.846 |
| R-HSA-212436 | Generic Transcription Pathway | 0.256473 | 0.591 |
| R-HSA-446728 | Cell junction organization | 0.120315 | 0.920 |
| R-HSA-2028269 | Signaling by Hippo | 0.037565 | 1.425 |
| R-HSA-8983711 | OAS antiviral response | 0.198034 | 0.703 |
| R-HSA-1500931 | Cell-Cell communication | 0.184309 | 0.734 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.198034 | 0.703 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.307183 | 0.513 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.269356 | 0.570 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.214582 | 0.668 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.137756 | 0.861 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.329788 | 0.482 |
| R-HSA-913531 | Interferon Signaling | 0.196889 | 0.706 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.160896 | 0.793 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.329788 | 0.482 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.253449 | 0.596 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.266599 | 0.574 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.322309 | 0.492 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.332348 | 0.478 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.332348 | 0.478 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.332348 | 0.478 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.334455 | 0.476 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.336034 | 0.474 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.337352 | 0.472 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.338440 | 0.471 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.338981 | 0.470 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.338981 | 0.470 |
| R-HSA-429947 | Deadenylation of mRNA | 0.338981 | 0.470 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.338981 | 0.470 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.338981 | 0.470 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.342345 | 0.466 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.342345 | 0.466 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.344655 | 0.463 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.348049 | 0.458 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.348049 | 0.458 |
| R-HSA-9620244 | Long-term potentiation | 0.348049 | 0.458 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.348049 | 0.458 |
| R-HSA-3214842 | HDMs demethylate histones | 0.348049 | 0.458 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.352295 | 0.453 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.356993 | 0.447 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.356993 | 0.447 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.356993 | 0.447 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.356993 | 0.447 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.362192 | 0.441 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.362192 | 0.441 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.363312 | 0.440 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.365814 | 0.437 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.365814 | 0.437 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.365814 | 0.437 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.365814 | 0.437 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.366421 | 0.436 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.367120 | 0.435 |
| R-HSA-72172 | mRNA Splicing | 0.372637 | 0.429 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.374515 | 0.427 |
| R-HSA-5357801 | Programmed Cell Death | 0.375744 | 0.425 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.379115 | 0.421 |
| R-HSA-70268 | Pyruvate metabolism | 0.381813 | 0.418 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.381813 | 0.418 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.382368 | 0.418 |
| R-HSA-9663891 | Selective autophagy | 0.386679 | 0.413 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.391562 | 0.407 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.391562 | 0.407 |
| R-HSA-2424491 | DAP12 signaling | 0.391562 | 0.407 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.391562 | 0.407 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.391562 | 0.407 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.394601 | 0.404 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.395219 | 0.403 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.396360 | 0.402 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.397444 | 0.401 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.399912 | 0.398 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.399912 | 0.398 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.399912 | 0.398 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.399912 | 0.398 |
| R-HSA-1538133 | G0 and Early G1 | 0.408147 | 0.389 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.408147 | 0.389 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.410750 | 0.386 |
| R-HSA-418990 | Adherens junctions interactions | 0.415950 | 0.381 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.415985 | 0.381 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.416270 | 0.381 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.416270 | 0.381 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.416270 | 0.381 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.416270 | 0.381 |
| R-HSA-9930044 | Nuclear RNA decay | 0.416270 | 0.381 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.416270 | 0.381 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.416270 | 0.381 |
| R-HSA-354192 | Integrin signaling | 0.416270 | 0.381 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.420249 | 0.376 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.422295 | 0.374 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.424281 | 0.372 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.424281 | 0.372 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.424281 | 0.372 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.424281 | 0.372 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.432184 | 0.364 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.432184 | 0.364 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.432184 | 0.364 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.432184 | 0.364 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.432184 | 0.364 |
| R-HSA-5673000 | RAF activation | 0.432184 | 0.364 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.434350 | 0.362 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.434350 | 0.362 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.437777 | 0.359 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.439978 | 0.357 |
| R-HSA-169911 | Regulation of Apoptosis | 0.439978 | 0.357 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.441128 | 0.355 |
| R-HSA-190236 | Signaling by FGFR | 0.443649 | 0.353 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.446498 | 0.350 |
| R-HSA-3371511 | HSF1 activation | 0.447666 | 0.349 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.447666 | 0.349 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.447666 | 0.349 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.447666 | 0.349 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.448267 | 0.348 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.452863 | 0.344 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.455248 | 0.342 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.461990 | 0.335 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.461990 | 0.335 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.462727 | 0.335 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.470104 | 0.328 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.470104 | 0.328 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.470104 | 0.328 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.475512 | 0.323 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.475512 | 0.323 |
| R-HSA-9833110 | RSV-host interactions | 0.475512 | 0.323 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.477380 | 0.321 |
| R-HSA-3371568 | Attenuation phase | 0.477380 | 0.321 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.477380 | 0.321 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.477380 | 0.321 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.477380 | 0.321 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.477380 | 0.321 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.477380 | 0.321 |
| R-HSA-9646399 | Aggrephagy | 0.477380 | 0.321 |
| R-HSA-202433 | Generation of second messenger molecules | 0.477380 | 0.321 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.479974 | 0.319 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.484557 | 0.315 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.484557 | 0.315 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.484557 | 0.315 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.484557 | 0.315 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.484557 | 0.315 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.487345 | 0.312 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.491635 | 0.308 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.491635 | 0.308 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.501124 | 0.300 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.504404 | 0.297 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.505503 | 0.296 |
| R-HSA-8854214 | TBC/RABGAPs | 0.505503 | 0.296 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.506381 | 0.296 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.510546 | 0.292 |
| R-HSA-2172127 | DAP12 interactions | 0.512295 | 0.290 |
| R-HSA-190828 | Gap junction trafficking | 0.512295 | 0.290 |
| R-HSA-112316 | Neuronal System | 0.512864 | 0.290 |
| R-HSA-421270 | Cell-cell junction organization | 0.514645 | 0.288 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.518994 | 0.285 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.518994 | 0.285 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.518994 | 0.285 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.518994 | 0.285 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.518994 | 0.285 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.525602 | 0.279 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.525602 | 0.279 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.525602 | 0.279 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.525602 | 0.279 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.525602 | 0.279 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.531654 | 0.274 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.532119 | 0.274 |
| R-HSA-449147 | Signaling by Interleukins | 0.534362 | 0.272 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.534631 | 0.272 |
| R-HSA-69275 | G2/M Transition | 0.538016 | 0.269 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.538547 | 0.269 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.538547 | 0.269 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.538547 | 0.269 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.538547 | 0.269 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.539923 | 0.268 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.539923 | 0.268 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.544557 | 0.264 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.544887 | 0.264 |
| R-HSA-5617833 | Cilium Assembly | 0.551044 | 0.259 |
| R-HSA-68875 | Mitotic Prophase | 0.552136 | 0.258 |
| R-HSA-912446 | Meiotic recombination | 0.557309 | 0.254 |
| R-HSA-68877 | Mitotic Prometaphase | 0.560672 | 0.251 |
| R-HSA-72187 | mRNA 3'-end processing | 0.563392 | 0.249 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.563392 | 0.249 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.563392 | 0.249 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.564121 | 0.249 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.564121 | 0.249 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.568064 | 0.246 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.569392 | 0.245 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.569392 | 0.245 |
| R-HSA-9609690 | HCMV Early Events | 0.570176 | 0.244 |
| R-HSA-194138 | Signaling by VEGF | 0.575874 | 0.240 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.581148 | 0.236 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.586905 | 0.231 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.586905 | 0.231 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.592584 | 0.227 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.592584 | 0.227 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.597248 | 0.224 |
| R-HSA-9658195 | Leishmania infection | 0.597248 | 0.224 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.598185 | 0.223 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.598185 | 0.223 |
| R-HSA-9843745 | Adipogenesis | 0.602398 | 0.220 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.603709 | 0.219 |
| R-HSA-191859 | snRNP Assembly | 0.603709 | 0.219 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.603709 | 0.219 |
| R-HSA-186712 | Regulation of beta-cell development | 0.603709 | 0.219 |
| R-HSA-9909396 | Circadian clock | 0.606083 | 0.217 |
| R-HSA-983189 | Kinesins | 0.609157 | 0.215 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.614531 | 0.211 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.614531 | 0.211 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.614531 | 0.211 |
| R-HSA-9707616 | Heme signaling | 0.619832 | 0.208 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.619832 | 0.208 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.619832 | 0.208 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.619832 | 0.208 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.619832 | 0.208 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.625060 | 0.204 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.627656 | 0.202 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.631161 | 0.200 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.640318 | 0.194 |
| R-HSA-1632852 | Macroautophagy | 0.641524 | 0.193 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.645265 | 0.190 |
| R-HSA-9830369 | Kidney development | 0.645265 | 0.190 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.650145 | 0.187 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.656281 | 0.183 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.659704 | 0.181 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.664386 | 0.178 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.664386 | 0.178 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.669004 | 0.175 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.669004 | 0.175 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.669004 | 0.175 |
| R-HSA-9758941 | Gastrulation | 0.671239 | 0.173 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.673558 | 0.172 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.674416 | 0.171 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.674416 | 0.171 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.677567 | 0.169 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.678051 | 0.169 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.680694 | 0.167 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.682481 | 0.166 |
| R-HSA-9609507 | Protein localization | 0.683795 | 0.165 |
| R-HSA-73887 | Death Receptor Signaling | 0.686873 | 0.163 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.689925 | 0.161 |
| R-HSA-1989781 | PPARA activates gene expression | 0.689925 | 0.161 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.691161 | 0.160 |
| R-HSA-9612973 | Autophagy | 0.692954 | 0.159 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.695412 | 0.158 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.695958 | 0.157 |
| R-HSA-9659379 | Sensory processing of sound | 0.699605 | 0.155 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.703740 | 0.153 |
| R-HSA-9833482 | PKR-mediated signaling | 0.703740 | 0.153 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.707818 | 0.150 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.711841 | 0.148 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.715809 | 0.145 |
| R-HSA-9609646 | HCMV Infection | 0.720757 | 0.142 |
| R-HSA-1500620 | Meiosis | 0.723581 | 0.141 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.723581 | 0.141 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.723581 | 0.141 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.727388 | 0.138 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.727388 | 0.138 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.732843 | 0.135 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.734423 | 0.134 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.735517 | 0.133 |
| R-HSA-156902 | Peptide chain elongation | 0.738497 | 0.132 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.740798 | 0.130 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.742099 | 0.130 |
| R-HSA-73884 | Base Excision Repair | 0.745652 | 0.127 |
| R-HSA-8953854 | Metabolism of RNA | 0.746815 | 0.127 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.749156 | 0.125 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.750266 | 0.125 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.752612 | 0.123 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.756020 | 0.121 |
| R-HSA-168255 | Influenza Infection | 0.758577 | 0.120 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.759382 | 0.120 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.760173 | 0.119 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.765968 | 0.116 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.769193 | 0.114 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.769193 | 0.114 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.769193 | 0.114 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.772374 | 0.112 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.772374 | 0.112 |
| R-HSA-1296071 | Potassium Channels | 0.772374 | 0.112 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.775511 | 0.110 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.775511 | 0.110 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.778606 | 0.109 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.779886 | 0.108 |
| R-HSA-70171 | Glycolysis | 0.784668 | 0.105 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.787636 | 0.104 |
| R-HSA-1640170 | Cell Cycle | 0.790520 | 0.102 |
| R-HSA-1483255 | PI Metabolism | 0.790564 | 0.102 |
| R-HSA-192823 | Viral mRNA Translation | 0.793452 | 0.100 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.796300 | 0.099 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.805733 | 0.094 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.807307 | 0.093 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.807307 | 0.093 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.807307 | 0.093 |
| R-HSA-211000 | Gene Silencing by RNA | 0.807307 | 0.093 |
| R-HSA-68886 | M Phase | 0.808118 | 0.093 |
| R-HSA-9679506 | SARS-CoV Infections | 0.808287 | 0.092 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.809965 | 0.092 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.809965 | 0.092 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.809965 | 0.092 |
| R-HSA-1483257 | Phospholipid metabolism | 0.810766 | 0.091 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.811761 | 0.091 |
| R-HSA-202403 | TCR signaling | 0.815171 | 0.089 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.820236 | 0.086 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.820236 | 0.086 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.827575 | 0.082 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.829955 | 0.081 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.829955 | 0.081 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.832462 | 0.080 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.834616 | 0.079 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.834616 | 0.079 |
| R-HSA-373760 | L1CAM interactions | 0.834616 | 0.079 |
| R-HSA-70326 | Glucose metabolism | 0.836899 | 0.077 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.841371 | 0.075 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.845720 | 0.073 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.849951 | 0.071 |
| R-HSA-2262752 | Cellular responses to stress | 0.853420 | 0.069 |
| R-HSA-162906 | HIV Infection | 0.855840 | 0.068 |
| R-HSA-69206 | G1/S Transition | 0.856082 | 0.067 |
| R-HSA-114608 | Platelet degranulation | 0.860030 | 0.065 |
| R-HSA-72312 | rRNA processing | 0.863444 | 0.064 |
| R-HSA-1474165 | Reproduction | 0.867606 | 0.062 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.871239 | 0.060 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.873019 | 0.059 |
| R-HSA-9824446 | Viral Infection Pathways | 0.873392 | 0.059 |
| R-HSA-1280218 | Adaptive Immune System | 0.875261 | 0.058 |
| R-HSA-1266738 | Developmental Biology | 0.877900 | 0.057 |
| R-HSA-163685 | Integration of energy metabolism | 0.879894 | 0.056 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.883192 | 0.054 |
| R-HSA-6807070 | PTEN Regulation | 0.884806 | 0.053 |
| R-HSA-9664407 | Parasite infection | 0.886399 | 0.052 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.886399 | 0.052 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.886399 | 0.052 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.887970 | 0.052 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.891046 | 0.050 |
| R-HSA-5688426 | Deubiquitination | 0.893916 | 0.049 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.896950 | 0.047 |
| R-HSA-69242 | S Phase | 0.899781 | 0.046 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.909645 | 0.041 |
| R-HSA-9610379 | HCMV Late Events | 0.911593 | 0.040 |
| R-HSA-162587 | HIV Life Cycle | 0.911593 | 0.040 |
| R-HSA-9711097 | Cellular response to starvation | 0.912816 | 0.040 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.914205 | 0.039 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.915213 | 0.038 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.919812 | 0.036 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.921612 | 0.035 |
| R-HSA-5619102 | SLC transporter disorders | 0.923098 | 0.035 |
| R-HSA-168256 | Immune System | 0.925274 | 0.034 |
| R-HSA-72306 | tRNA processing | 0.927271 | 0.033 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.931218 | 0.031 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.932472 | 0.030 |
| R-HSA-3781865 | Diseases of glycosylation | 0.940179 | 0.027 |
| R-HSA-1643685 | Disease | 0.943590 | 0.025 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.945750 | 0.024 |
| R-HSA-8957322 | Metabolism of steroids | 0.951593 | 0.022 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.952161 | 0.021 |
| R-HSA-397014 | Muscle contraction | 0.960112 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.960310 | 0.018 |
| R-HSA-6798695 | Neutrophil degranulation | 0.961755 | 0.017 |
| R-HSA-68882 | Mitotic Anaphase | 0.962283 | 0.017 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.962807 | 0.016 |
| R-HSA-8951664 | Neddylation | 0.964831 | 0.016 |
| R-HSA-5663205 | Infectious disease | 0.966987 | 0.015 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.971890 | 0.012 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.975566 | 0.011 |
| R-HSA-416476 | G alpha (q) signalling events | 0.980750 | 0.008 |
| R-HSA-109582 | Hemostasis | 0.987522 | 0.005 |
| R-HSA-597592 | Post-translational protein modification | 0.993959 | 0.003 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.995223 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.996320 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997088 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997472 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998096 | 0.001 |
| R-HSA-72766 | Translation | 0.998149 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.998720 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999720 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999835 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999875 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999946 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999984 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.807 | 0.538 | 1 | 0.941 |
HIPK2 |
0.803 | 0.503 | 1 | 0.951 |
CDK3 |
0.803 | 0.498 | 1 | 0.937 |
KIS |
0.802 | 0.450 | 1 | 0.925 |
CDK19 |
0.800 | 0.505 | 1 | 0.935 |
CDK1 |
0.800 | 0.516 | 1 | 0.928 |
CDK5 |
0.800 | 0.536 | 1 | 0.917 |
P38G |
0.799 | 0.546 | 1 | 0.937 |
CDK17 |
0.796 | 0.527 | 1 | 0.933 |
CDK8 |
0.796 | 0.505 | 1 | 0.922 |
JNK2 |
0.796 | 0.555 | 1 | 0.935 |
CDK7 |
0.794 | 0.507 | 1 | 0.930 |
CDK13 |
0.792 | 0.514 | 1 | 0.937 |
CLK3 |
0.791 | 0.330 | 1 | 0.756 |
P38B |
0.791 | 0.545 | 1 | 0.920 |
CDK12 |
0.791 | 0.520 | 1 | 0.940 |
DYRK2 |
0.790 | 0.466 | 1 | 0.919 |
CDK16 |
0.790 | 0.506 | 1 | 0.934 |
ERK1 |
0.790 | 0.522 | 1 | 0.930 |
CDK10 |
0.789 | 0.486 | 1 | 0.937 |
JNK3 |
0.788 | 0.538 | 1 | 0.929 |
HIPK4 |
0.788 | 0.352 | 1 | 0.791 |
P38D |
0.787 | 0.518 | 1 | 0.951 |
HIPK1 |
0.786 | 0.450 | 1 | 0.917 |
P38A |
0.785 | 0.529 | 1 | 0.902 |
CDK9 |
0.784 | 0.496 | 1 | 0.937 |
SRPK1 |
0.783 | 0.243 | -3 | 0.718 |
CDK14 |
0.783 | 0.497 | 1 | 0.930 |
DYRK4 |
0.781 | 0.465 | 1 | 0.953 |
NLK |
0.780 | 0.462 | 1 | 0.785 |
DYRK1B |
0.776 | 0.436 | 1 | 0.932 |
MAK |
0.775 | 0.413 | -2 | 0.856 |
CDK6 |
0.775 | 0.504 | 1 | 0.936 |
HIPK3 |
0.773 | 0.433 | 1 | 0.884 |
DYRK1A |
0.771 | 0.394 | 1 | 0.888 |
ERK5 |
0.771 | 0.276 | 1 | 0.709 |
CDK4 |
0.770 | 0.505 | 1 | 0.943 |
ERK2 |
0.770 | 0.483 | 1 | 0.916 |
MTOR |
0.770 | 0.225 | 1 | 0.599 |
CDKL5 |
0.768 | 0.162 | -3 | 0.765 |
CDK2 |
0.768 | 0.391 | 1 | 0.862 |
JNK1 |
0.768 | 0.478 | 1 | 0.924 |
COT |
0.768 | 0.049 | 2 | 0.873 |
CLK2 |
0.767 | 0.263 | -3 | 0.697 |
ICK |
0.766 | 0.277 | -3 | 0.807 |
SRPK2 |
0.765 | 0.173 | -3 | 0.634 |
CLK1 |
0.763 | 0.250 | -3 | 0.698 |
DYRK3 |
0.762 | 0.332 | 1 | 0.894 |
CDKL1 |
0.761 | 0.129 | -3 | 0.764 |
CLK4 |
0.758 | 0.222 | -3 | 0.715 |
MOS |
0.757 | 0.074 | 1 | 0.520 |
SRPK3 |
0.757 | 0.159 | -3 | 0.676 |
PRP4 |
0.756 | 0.317 | -3 | 0.781 |
MOK |
0.756 | 0.340 | 1 | 0.845 |
NDR2 |
0.751 | -0.016 | -3 | 0.804 |
PIM3 |
0.750 | -0.002 | -3 | 0.793 |
ERK7 |
0.750 | 0.240 | 2 | 0.657 |
PRPK |
0.750 | -0.033 | -1 | 0.833 |
PRKD1 |
0.749 | 0.044 | -3 | 0.820 |
CDC7 |
0.748 | -0.061 | 1 | 0.456 |
MST4 |
0.746 | -0.000 | 2 | 0.874 |
WNK1 |
0.746 | -0.013 | -2 | 0.876 |
CHAK2 |
0.746 | -0.001 | -1 | 0.817 |
ATR |
0.746 | -0.025 | 1 | 0.501 |
SKMLCK |
0.745 | 0.052 | -2 | 0.859 |
NEK6 |
0.745 | -0.003 | -2 | 0.847 |
PRKD2 |
0.744 | 0.034 | -3 | 0.746 |
MPSK1 |
0.743 | 0.181 | 1 | 0.551 |
PKCD |
0.743 | 0.042 | 2 | 0.814 |
NDR1 |
0.743 | -0.042 | -3 | 0.795 |
RSK2 |
0.742 | 0.003 | -3 | 0.736 |
PKN2 |
0.742 | -0.005 | -3 | 0.799 |
NUAK2 |
0.741 | -0.011 | -3 | 0.793 |
CAMK1B |
0.741 | -0.028 | -3 | 0.812 |
PKCB |
0.741 | 0.054 | 2 | 0.780 |
PKCA |
0.741 | 0.065 | 2 | 0.774 |
TBK1 |
0.741 | -0.097 | 1 | 0.405 |
RAF1 |
0.741 | -0.113 | 1 | 0.466 |
GRK1 |
0.741 | 0.021 | -2 | 0.803 |
AURC |
0.740 | 0.034 | -2 | 0.655 |
ULK2 |
0.740 | -0.100 | 2 | 0.799 |
PIM1 |
0.740 | 0.018 | -3 | 0.736 |
BMPR2 |
0.740 | -0.119 | -2 | 0.870 |
IRE1 |
0.740 | -0.004 | 1 | 0.492 |
NIK |
0.740 | -0.003 | -3 | 0.833 |
DSTYK |
0.740 | -0.085 | 2 | 0.896 |
PKN3 |
0.740 | -0.015 | -3 | 0.784 |
GCN2 |
0.740 | -0.140 | 2 | 0.805 |
MLK3 |
0.739 | 0.054 | 2 | 0.780 |
MAPKAPK3 |
0.739 | -0.013 | -3 | 0.758 |
PDHK4 |
0.738 | -0.187 | 1 | 0.527 |
P90RSK |
0.738 | -0.001 | -3 | 0.739 |
LATS2 |
0.738 | -0.050 | -5 | 0.133 |
MLK1 |
0.738 | -0.064 | 2 | 0.842 |
IKKB |
0.738 | -0.132 | -2 | 0.710 |
CAMLCK |
0.737 | 0.007 | -2 | 0.834 |
MLK2 |
0.737 | 0.026 | 2 | 0.832 |
RSK3 |
0.737 | -0.018 | -3 | 0.728 |
PKCG |
0.737 | 0.021 | 2 | 0.778 |
IKKE |
0.736 | -0.112 | 1 | 0.399 |
TGFBR2 |
0.736 | -0.053 | -2 | 0.788 |
MNK2 |
0.736 | 0.034 | -2 | 0.774 |
MAPKAPK2 |
0.735 | 0.008 | -3 | 0.704 |
PKCZ |
0.735 | 0.032 | 2 | 0.822 |
RIPK3 |
0.735 | -0.088 | 3 | 0.702 |
NEK7 |
0.734 | -0.114 | -3 | 0.827 |
PDHK1 |
0.733 | -0.170 | 1 | 0.508 |
AMPKA1 |
0.733 | -0.044 | -3 | 0.816 |
TSSK1 |
0.732 | 0.004 | -3 | 0.837 |
TSSK2 |
0.732 | -0.009 | -5 | 0.195 |
LATS1 |
0.732 | 0.007 | -3 | 0.822 |
GRK7 |
0.732 | 0.018 | 1 | 0.448 |
GRK5 |
0.732 | -0.111 | -3 | 0.800 |
DAPK2 |
0.732 | -0.024 | -3 | 0.827 |
PKACG |
0.731 | -0.029 | -2 | 0.740 |
MNK1 |
0.731 | 0.021 | -2 | 0.786 |
P70S6KB |
0.731 | -0.032 | -3 | 0.749 |
NEK9 |
0.730 | -0.075 | 2 | 0.860 |
CAMK2G |
0.730 | -0.110 | 2 | 0.779 |
GSK3A |
0.730 | 0.145 | 4 | 0.439 |
IRE2 |
0.730 | -0.013 | 2 | 0.780 |
BCKDK |
0.730 | -0.113 | -1 | 0.768 |
MARK4 |
0.729 | -0.062 | 4 | 0.800 |
AMPKA2 |
0.729 | -0.030 | -3 | 0.783 |
VRK2 |
0.729 | 0.112 | 1 | 0.581 |
PKACB |
0.728 | 0.022 | -2 | 0.666 |
PKR |
0.728 | -0.012 | 1 | 0.514 |
PHKG1 |
0.728 | -0.021 | -3 | 0.785 |
HUNK |
0.728 | -0.110 | 2 | 0.824 |
BUB1 |
0.728 | 0.113 | -5 | 0.216 |
CAMK2D |
0.728 | -0.057 | -3 | 0.814 |
PKG2 |
0.728 | 0.010 | -2 | 0.676 |
PRKD3 |
0.728 | -0.004 | -3 | 0.710 |
PAK1 |
0.727 | -0.018 | -2 | 0.778 |
MASTL |
0.726 | -0.112 | -2 | 0.801 |
IKKA |
0.726 | -0.086 | -2 | 0.711 |
RSK4 |
0.726 | -0.012 | -3 | 0.698 |
ULK1 |
0.726 | -0.144 | -3 | 0.790 |
PKCH |
0.725 | -0.016 | 2 | 0.762 |
SGK3 |
0.725 | 0.007 | -3 | 0.739 |
PAK3 |
0.725 | -0.039 | -2 | 0.763 |
WNK3 |
0.725 | -0.178 | 1 | 0.467 |
PIM2 |
0.725 | 0.005 | -3 | 0.704 |
AKT2 |
0.724 | 0.019 | -3 | 0.645 |
BMPR1B |
0.724 | -0.023 | 1 | 0.416 |
CHAK1 |
0.724 | -0.050 | 2 | 0.800 |
MST3 |
0.724 | 0.044 | 2 | 0.878 |
TTBK2 |
0.724 | -0.115 | 2 | 0.732 |
NEK2 |
0.723 | -0.033 | 2 | 0.848 |
MLK4 |
0.723 | -0.026 | 2 | 0.764 |
DLK |
0.723 | -0.143 | 1 | 0.467 |
RIPK1 |
0.723 | -0.150 | 1 | 0.473 |
ANKRD3 |
0.722 | -0.128 | 1 | 0.489 |
NIM1 |
0.722 | -0.076 | 3 | 0.739 |
SMG1 |
0.722 | -0.046 | 1 | 0.477 |
YSK4 |
0.721 | -0.076 | 1 | 0.432 |
MELK |
0.721 | -0.051 | -3 | 0.771 |
PINK1 |
0.720 | 0.060 | 1 | 0.666 |
CAMK2A |
0.719 | -0.017 | 2 | 0.755 |
AURB |
0.719 | -0.015 | -2 | 0.646 |
PRKX |
0.719 | 0.007 | -3 | 0.636 |
PAK6 |
0.719 | -0.018 | -2 | 0.672 |
ALK4 |
0.718 | -0.064 | -2 | 0.814 |
IRAK4 |
0.718 | -0.016 | 1 | 0.477 |
PKCE |
0.718 | 0.032 | 2 | 0.773 |
DNAPK |
0.717 | -0.032 | 1 | 0.424 |
PKCT |
0.717 | -0.002 | 2 | 0.766 |
NUAK1 |
0.717 | -0.064 | -3 | 0.740 |
FAM20C |
0.717 | -0.025 | 2 | 0.592 |
TGFBR1 |
0.717 | -0.046 | -2 | 0.785 |
CAMK4 |
0.716 | -0.115 | -3 | 0.769 |
QSK |
0.716 | -0.047 | 4 | 0.778 |
MSK2 |
0.716 | -0.053 | -3 | 0.715 |
QIK |
0.715 | -0.103 | -3 | 0.796 |
ATM |
0.715 | -0.086 | 1 | 0.441 |
GRK6 |
0.715 | -0.148 | 1 | 0.448 |
DCAMKL1 |
0.715 | -0.021 | -3 | 0.744 |
NEK5 |
0.714 | -0.005 | 1 | 0.478 |
TAO3 |
0.714 | -0.009 | 1 | 0.478 |
PKCI |
0.714 | 0.000 | 2 | 0.802 |
GRK4 |
0.714 | -0.152 | -2 | 0.833 |
TLK2 |
0.713 | -0.091 | 1 | 0.444 |
WNK4 |
0.713 | -0.085 | -2 | 0.872 |
MYLK4 |
0.713 | -0.050 | -2 | 0.750 |
MEK1 |
0.712 | -0.137 | 2 | 0.826 |
PERK |
0.712 | -0.096 | -2 | 0.818 |
GSK3B |
0.712 | 0.039 | 4 | 0.434 |
PLK1 |
0.712 | -0.120 | -2 | 0.785 |
AKT1 |
0.712 | 0.003 | -3 | 0.671 |
CK1E |
0.711 | -0.029 | -3 | 0.483 |
LKB1 |
0.711 | 0.093 | -3 | 0.828 |
MEK5 |
0.711 | -0.112 | 2 | 0.827 |
MSK1 |
0.711 | -0.035 | -3 | 0.720 |
PAK2 |
0.711 | -0.075 | -2 | 0.756 |
MEKK1 |
0.711 | -0.073 | 1 | 0.473 |
TNIK |
0.710 | 0.074 | 3 | 0.897 |
CAMK2B |
0.710 | -0.068 | 2 | 0.734 |
ACVR2B |
0.710 | -0.081 | -2 | 0.786 |
CAMK1G |
0.710 | -0.053 | -3 | 0.708 |
HRI |
0.710 | -0.112 | -2 | 0.834 |
CHK1 |
0.710 | -0.116 | -3 | 0.795 |
MEKK2 |
0.710 | -0.071 | 2 | 0.813 |
SSTK |
0.709 | -0.007 | 4 | 0.779 |
SIK |
0.709 | -0.066 | -3 | 0.710 |
ZAK |
0.709 | -0.089 | 1 | 0.440 |
MARK3 |
0.709 | -0.054 | 4 | 0.721 |
BRSK2 |
0.709 | -0.086 | -3 | 0.779 |
HASPIN |
0.709 | 0.066 | -1 | 0.694 |
PLK4 |
0.708 | -0.093 | 2 | 0.621 |
HGK |
0.707 | 0.030 | 3 | 0.889 |
PASK |
0.707 | -0.052 | -3 | 0.817 |
PKACA |
0.707 | -0.010 | -2 | 0.618 |
GCK |
0.707 | 0.004 | 1 | 0.454 |
ACVR2A |
0.707 | -0.104 | -2 | 0.776 |
BRSK1 |
0.706 | -0.076 | -3 | 0.750 |
AKT3 |
0.706 | 0.022 | -3 | 0.598 |
ALK2 |
0.706 | -0.083 | -2 | 0.794 |
GAK |
0.706 | -0.034 | 1 | 0.541 |
TAO2 |
0.706 | -0.014 | 2 | 0.865 |
KHS1 |
0.705 | 0.057 | 1 | 0.454 |
DRAK1 |
0.705 | -0.100 | 1 | 0.376 |
EEF2K |
0.705 | 0.012 | 3 | 0.869 |
MEKK3 |
0.705 | -0.164 | 1 | 0.462 |
CK1D |
0.705 | -0.013 | -3 | 0.435 |
PHKG2 |
0.705 | -0.069 | -3 | 0.745 |
DCAMKL2 |
0.704 | -0.056 | -3 | 0.763 |
GRK2 |
0.703 | -0.085 | -2 | 0.719 |
PKN1 |
0.703 | -0.015 | -3 | 0.692 |
MEKK6 |
0.703 | -0.016 | 1 | 0.465 |
MAP3K15 |
0.703 | -0.001 | 1 | 0.444 |
MAPKAPK5 |
0.703 | -0.105 | -3 | 0.696 |
LRRK2 |
0.703 | 0.020 | 2 | 0.869 |
NEK11 |
0.703 | -0.091 | 1 | 0.460 |
HPK1 |
0.703 | -0.002 | 1 | 0.451 |
SMMLCK |
0.703 | -0.061 | -3 | 0.774 |
BRAF |
0.703 | -0.094 | -4 | 0.782 |
KHS2 |
0.703 | 0.042 | 1 | 0.462 |
PDK1 |
0.702 | -0.044 | 1 | 0.476 |
P70S6K |
0.702 | -0.063 | -3 | 0.671 |
SGK1 |
0.702 | 0.011 | -3 | 0.577 |
SNRK |
0.701 | -0.150 | 2 | 0.680 |
TLK1 |
0.701 | -0.123 | -2 | 0.821 |
AURA |
0.701 | -0.052 | -2 | 0.615 |
NEK4 |
0.701 | -0.035 | 1 | 0.458 |
MINK |
0.701 | -0.025 | 1 | 0.446 |
SBK |
0.701 | 0.061 | -3 | 0.534 |
PBK |
0.701 | 0.008 | 1 | 0.502 |
ROCK2 |
0.701 | 0.008 | -3 | 0.752 |
LOK |
0.700 | -0.010 | -2 | 0.749 |
MARK2 |
0.700 | -0.093 | 4 | 0.685 |
NEK8 |
0.700 | -0.087 | 2 | 0.847 |
PLK3 |
0.699 | -0.118 | 2 | 0.749 |
NEK1 |
0.699 | 0.012 | 1 | 0.461 |
PAK5 |
0.699 | -0.044 | -2 | 0.621 |
CK1A2 |
0.698 | -0.036 | -3 | 0.432 |
VRK1 |
0.697 | -0.023 | 2 | 0.859 |
CK1G1 |
0.697 | -0.064 | -3 | 0.464 |
MST2 |
0.697 | -0.053 | 1 | 0.449 |
CHK2 |
0.696 | -0.021 | -3 | 0.597 |
CAMKK1 |
0.696 | -0.102 | -2 | 0.706 |
MRCKB |
0.696 | -0.012 | -3 | 0.692 |
CAMK1D |
0.696 | -0.038 | -3 | 0.644 |
PAK4 |
0.696 | -0.030 | -2 | 0.628 |
CAMKK2 |
0.696 | -0.063 | -2 | 0.707 |
BMPR1A |
0.695 | -0.085 | 1 | 0.395 |
MARK1 |
0.695 | -0.109 | 4 | 0.749 |
YSK1 |
0.694 | -0.021 | 2 | 0.846 |
CAMK1A |
0.694 | -0.002 | -3 | 0.612 |
SLK |
0.693 | -0.047 | -2 | 0.707 |
AAK1 |
0.692 | 0.062 | 1 | 0.475 |
TTBK1 |
0.691 | -0.148 | 2 | 0.647 |
BIKE |
0.691 | 0.026 | 1 | 0.504 |
DAPK3 |
0.691 | -0.051 | -3 | 0.749 |
DMPK1 |
0.691 | 0.007 | -3 | 0.707 |
MST1 |
0.690 | -0.044 | 1 | 0.441 |
MRCKA |
0.690 | -0.046 | -3 | 0.708 |
TAK1 |
0.689 | -0.097 | 1 | 0.439 |
MYO3B |
0.689 | 0.042 | 2 | 0.854 |
STK33 |
0.688 | -0.079 | 2 | 0.621 |
OSR1 |
0.688 | 0.002 | 2 | 0.811 |
GRK3 |
0.687 | -0.094 | -2 | 0.681 |
IRAK1 |
0.686 | -0.203 | -1 | 0.725 |
PDHK3_TYR |
0.686 | 0.166 | 4 | 0.884 |
CK2A2 |
0.685 | -0.065 | 1 | 0.353 |
LIMK2_TYR |
0.685 | 0.167 | -3 | 0.869 |
CRIK |
0.685 | -0.021 | -3 | 0.678 |
ROCK1 |
0.685 | -0.015 | -3 | 0.709 |
NEK3 |
0.683 | -0.078 | 1 | 0.457 |
DAPK1 |
0.681 | -0.070 | -3 | 0.731 |
TTK |
0.681 | -0.014 | -2 | 0.815 |
TESK1_TYR |
0.681 | 0.099 | 3 | 0.869 |
PKMYT1_TYR |
0.679 | 0.087 | 3 | 0.820 |
PKG1 |
0.679 | -0.041 | -2 | 0.594 |
MYO3A |
0.679 | -0.018 | 1 | 0.478 |
TAO1 |
0.679 | -0.026 | 1 | 0.431 |
ASK1 |
0.678 | -0.018 | 1 | 0.439 |
MEK2 |
0.677 | -0.138 | 2 | 0.800 |
PDHK4_TYR |
0.676 | 0.054 | 2 | 0.858 |
CK2A1 |
0.675 | -0.074 | 1 | 0.335 |
MAP2K4_TYR |
0.674 | 0.036 | -1 | 0.844 |
RIPK2 |
0.672 | -0.195 | 1 | 0.408 |
PLK2 |
0.672 | -0.093 | -3 | 0.710 |
MAP2K6_TYR |
0.671 | 0.009 | -1 | 0.852 |
MAP2K7_TYR |
0.670 | -0.058 | 2 | 0.849 |
LIMK1_TYR |
0.670 | 0.023 | 2 | 0.857 |
BMPR2_TYR |
0.669 | -0.005 | -1 | 0.856 |
PDHK1_TYR |
0.666 | -0.055 | -1 | 0.855 |
CK1A |
0.666 | -0.037 | -3 | 0.341 |
PINK1_TYR |
0.666 | -0.096 | 1 | 0.521 |
TNNI3K_TYR |
0.665 | 0.058 | 1 | 0.514 |
RET |
0.662 | -0.063 | 1 | 0.480 |
ALPHAK3 |
0.662 | -0.091 | -1 | 0.733 |
EPHA6 |
0.662 | -0.032 | -1 | 0.830 |
YANK3 |
0.661 | -0.054 | 2 | 0.408 |
MST1R |
0.660 | -0.046 | 3 | 0.772 |
JAK2 |
0.660 | -0.028 | 1 | 0.479 |
CSF1R |
0.660 | -0.007 | 3 | 0.742 |
ROS1 |
0.659 | -0.024 | 3 | 0.736 |
TYK2 |
0.659 | -0.094 | 1 | 0.469 |
EPHB4 |
0.658 | -0.027 | -1 | 0.793 |
TYRO3 |
0.658 | -0.053 | 3 | 0.768 |
STLK3 |
0.657 | -0.112 | 1 | 0.417 |
TNK1 |
0.657 | 0.016 | 3 | 0.741 |
TXK |
0.656 | -0.002 | 1 | 0.423 |
ABL2 |
0.655 | -0.032 | -1 | 0.759 |
TNK2 |
0.655 | -0.022 | 3 | 0.696 |
JAK1 |
0.655 | 0.002 | 1 | 0.433 |
LCK |
0.655 | -0.003 | -1 | 0.815 |
NEK10_TYR |
0.654 | -0.044 | 1 | 0.411 |
YES1 |
0.654 | -0.041 | -1 | 0.818 |
FGR |
0.654 | -0.076 | 1 | 0.467 |
DDR1 |
0.653 | -0.090 | 4 | 0.807 |
JAK3 |
0.653 | -0.074 | 1 | 0.457 |
BLK |
0.652 | -0.005 | -1 | 0.816 |
ABL1 |
0.651 | -0.045 | -1 | 0.752 |
HCK |
0.650 | -0.057 | -1 | 0.807 |
ITK |
0.650 | -0.066 | -1 | 0.767 |
WEE1_TYR |
0.650 | -0.033 | -1 | 0.710 |
KDR |
0.648 | -0.051 | 3 | 0.693 |
FGFR2 |
0.646 | -0.065 | 3 | 0.735 |
KIT |
0.644 | -0.087 | 3 | 0.741 |
MET |
0.644 | -0.064 | 3 | 0.732 |
EPHA4 |
0.643 | -0.072 | 2 | 0.755 |
DDR2 |
0.643 | 0.022 | 3 | 0.668 |
TEK |
0.643 | -0.054 | 3 | 0.681 |
BMX |
0.642 | -0.050 | -1 | 0.692 |
PDGFRB |
0.642 | -0.139 | 3 | 0.761 |
FER |
0.641 | -0.153 | 1 | 0.461 |
INSRR |
0.641 | -0.119 | 3 | 0.694 |
FYN |
0.641 | -0.032 | -1 | 0.806 |
EPHB3 |
0.640 | -0.104 | -1 | 0.778 |
FLT3 |
0.640 | -0.149 | 3 | 0.757 |
EPHB1 |
0.640 | -0.129 | 1 | 0.433 |
SRMS |
0.640 | -0.108 | 1 | 0.433 |
FGFR1 |
0.639 | -0.080 | 3 | 0.701 |
AXL |
0.639 | -0.097 | 3 | 0.719 |
EPHB2 |
0.638 | -0.088 | -1 | 0.768 |
MERTK |
0.637 | -0.084 | 3 | 0.711 |
PDGFRA |
0.637 | -0.155 | 3 | 0.759 |
BTK |
0.636 | -0.141 | -1 | 0.726 |
FLT1 |
0.635 | -0.106 | -1 | 0.786 |
EPHA1 |
0.634 | -0.083 | 3 | 0.710 |
TEC |
0.634 | -0.107 | -1 | 0.691 |
CK1G3 |
0.634 | -0.079 | -3 | 0.290 |
EPHA7 |
0.634 | -0.083 | 2 | 0.765 |
FRK |
0.633 | -0.089 | -1 | 0.799 |
ALK |
0.633 | -0.101 | 3 | 0.649 |
FGFR3 |
0.633 | -0.081 | 3 | 0.703 |
PTK6 |
0.632 | -0.141 | -1 | 0.689 |
LYN |
0.630 | -0.097 | 3 | 0.657 |
SRC |
0.630 | -0.070 | -1 | 0.791 |
EPHA3 |
0.629 | -0.111 | 2 | 0.732 |
ERBB2 |
0.629 | -0.139 | 1 | 0.424 |
LTK |
0.628 | -0.124 | 3 | 0.667 |
INSR |
0.628 | -0.129 | 3 | 0.683 |
MATK |
0.627 | -0.089 | -1 | 0.680 |
EGFR |
0.626 | -0.088 | 1 | 0.363 |
YANK2 |
0.626 | -0.074 | 2 | 0.418 |
FLT4 |
0.625 | -0.158 | 3 | 0.685 |
PTK2B |
0.625 | -0.092 | -1 | 0.736 |
NTRK3 |
0.625 | -0.110 | -1 | 0.722 |
PTK2 |
0.624 | -0.047 | -1 | 0.787 |
CK1G2 |
0.624 | -0.067 | -3 | 0.381 |
NTRK1 |
0.624 | -0.187 | -1 | 0.764 |
EPHA8 |
0.623 | -0.092 | -1 | 0.776 |
SYK |
0.622 | -0.067 | -1 | 0.756 |
NTRK2 |
0.622 | -0.190 | 3 | 0.691 |
MUSK |
0.621 | -0.094 | 1 | 0.359 |
CSK |
0.620 | -0.126 | 2 | 0.764 |
EPHA5 |
0.618 | -0.127 | 2 | 0.736 |
FGFR4 |
0.618 | -0.095 | -1 | 0.714 |
ZAP70 |
0.614 | -0.047 | -1 | 0.692 |
ERBB4 |
0.613 | -0.082 | 1 | 0.368 |
EPHA2 |
0.610 | -0.112 | -1 | 0.736 |
IGF1R |
0.609 | -0.127 | 3 | 0.609 |
FES |
0.593 | -0.141 | -1 | 0.666 |