Motif 253 (n=115)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A0MRY4 | None | S348 | ochoa | Spermatogenesis-associated protein 13 | None |
| A7KAX9 | ARHGAP32 | S1720 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O43301 | HSPA12A | S23 | ochoa | Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A) | Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. {ECO:0000269|PubMed:30679749}. |
| O43426 | SYNJ1 | S1223 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O60493 | SNX3 | S26 | ochoa | Sorting nexin-3 (Protein SDP3) | Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551). {ECO:0000250|UniProtKB:O70492, ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:18767904, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080, ECO:0000269|PubMed:24344282, ECO:0000305|PubMed:21725319}. |
| O75112 | LDB3 | S267 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75665 | OFD1 | S723 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O95382 | MAP3K6 | S957 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| P13073 | COX4I1 | S30 | ochoa | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P15923 | TCF3 | S189 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P15923 | TCF3 | S381 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16157 | ANK1 | S781 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17028 | ZNF24 | S289 | ochoa | Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17) | Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269|PubMed:10585455}. |
| P18146 | EGR1 | S378 | psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| P18615 | NELFE | S165 | ochoa | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062, ECO:0000269|PubMed:18303858, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27282391}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| P19544 | WT1 | S393 | psp | Wilms tumor protein (WT33) | Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}. |
| P20340 | RAB6A | S179 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P27707 | DCK | S63 | ochoa | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P29017 | CD1C | S215 | ochoa | T-cell surface glycoprotein CD1c (CD antigen CD1c) | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}. |
| P29372 | MPG | S33 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P31645 | SLC6A4 | S62 | ochoa | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P33981 | TTK | S258 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P37275 | ZEB1 | S571 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38935 | IGHMBP2 | S677 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P39880 | CUX1 | S1378 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41252 | IARS1 | S136 | ochoa | Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}. |
| P48634 | PRRC2A | S766 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49069 | CAMLG | S25 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P49815 | TSC2 | S1469 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P51811 | XK | S415 | ochoa | Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1) | Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}. |
| P52179 | MYOM1 | S1044 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52756 | RBM5 | S433 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P57679 | EVC | S138 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P78348 | ASIC1 | S487 | ochoa | Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). {ECO:0000250|UniProtKB:Q6NXK8, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:32915133, ECO:0000269|PubMed:34319232}.; FUNCTION: [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster (PubMed:21036899). Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present (PubMed:21036899). Also potentially permeable to lithium and potassium (PubMed:21036899). {ECO:0000269|PubMed:21036899}.; FUNCTION: [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro. {ECO:0000269|PubMed:21036899}. |
| P78363 | ABCA4 | S1317 | psp | Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein) | Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine is then isomerized to its all-trans isomer and reduced by RDH8 to produce all-trans-retinol. This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors, therefore preventing their accumulation and the formation of toxic bisretinoid (PubMed:10075733, PubMed:20404325, PubMed:22735453, PubMed:23144455, PubMed:24097981, PubMed:29847635, PubMed:33375396). Displays ATPase activity in vitro in absence of retinal substrate (PubMed:33605212, PubMed:39128720, PubMed:29847635, PubMed:33375396). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes N-retinylidene-phosphatidylethanolamine release (By similarity). {ECO:0000250|UniProtKB:F1MWM0, ECO:0000269|PubMed:10075733, ECO:0000269|PubMed:20404325, ECO:0000269|PubMed:22735453, ECO:0000269|PubMed:23144455, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:29847635, ECO:0000269|PubMed:33375396, ECO:0000269|PubMed:33605212, ECO:0000269|PubMed:39128720}. |
| Q04637 | EIF4G1 | S704 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04637 | EIF4G1 | S1098 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q13459 | MYO9B | S1329 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14004 | CDK13 | S1229 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14324 | MYBPC2 | S167 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14566 | MCM6 | S271 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q14676 | MDC1 | S1681 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q15424 | SAFB | S555 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15527 | SURF2 | S155 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q2KJY2 | KIF26B | S1144 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q5TBA9 | FRY | S2368 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5VT52 | RPRD2 | S626 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q6AI12 | ANKRD40 | S216 | ochoa | Ankyrin repeat domain-containing protein 40 | None |
| Q6AI39 | BICRAL | S687 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6DD87 | ZNF787 | S132 | ochoa | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q6P0Q8 | MAST2 | S1722 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1842 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z7B0 | FILIP1 | S967 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q7Z7L9 | ZSCAN2 | S316 | ochoa | Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29) (Zinc finger protein 854) | May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. {ECO:0000250}. |
| Q8IWR0 | ZC3H7A | S200 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8IYL3 | C1orf174 | S153 | ochoa | UPF0688 protein C1orf174 | None |
| Q8IZP0 | ABI1 | S330 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N720 | ZNF655 | S250 | ochoa | Zinc finger protein 655 (Vav-interacting Krueppel-like protein) | Probable transcription factor. {ECO:0000305}. |
| Q8N8K9 | KIAA1958 | S249 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8N9U0 | TC2N | S327 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8NC74 | RBBP8NL | S145 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NEY1 | NAV1 | S806 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFC6 | BOD1L1 | S1520 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFW9 | MYRIP | S335 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TEK3 | DOT1L | S1030 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TEQ0 | SNX29 | S646 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WUA7 | TBC1D22A | S135 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q92547 | TOPBP1 | S297 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92766 | RREB1 | S848 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92804 | TAF15 | S231 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q96CP6 | GRAMD1A | S584 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96F07 | CYFIP2 | S928 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96JM7 | L3MBTL3 | S678 | ochoa | Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96KQ4 | PPP1R13B | S665 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q99607 | ELF4 | S545 | ochoa | ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor) | Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) (PubMed:34326534, PubMed:35266071). {ECO:0000250, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:14625302, ECO:0000269|PubMed:14976184, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:34326534, ECO:0000269|PubMed:35266071, ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}. |
| Q99742 | NPAS1 | S478 | ochoa | Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) | May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97459}. |
| Q99961 | SH3GL1 | S292 | ochoa | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S805 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVG8 | KIFC3 | S808 | ochoa | Kinesin-like protein KIFC3 | Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}. |
| Q9BW19 | KIFC1 | S31 | ochoa|psp | Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET) | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}. |
| Q9BZE0 | GLIS2 | S245 | psp | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9C0I1 | MTMR12 | S699 | ochoa | Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) | Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000269|PubMed:11504939, ECO:0000269|PubMed:12847286, ECO:0000269|PubMed:23818870}. |
| Q9H5H4 | ZNF768 | S88 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H6Z4 | RANBP3 | S100 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H9R9 | DBNDD1 | S121 | ochoa | Dysbindin domain-containing protein 1 | None |
| Q9HAU0 | PLEKHA5 | S478 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HDC5 | JPH1 | S530 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQ84 | GPRC5C | S403 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQS7 | INCENP | S223 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQW6 | ANLN | S54 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQX3 | GPHN | S268 | ochoa | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}. |
| Q9NSV4 | DIAPH3 | S24 | ochoa | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}. |
| Q9P265 | DIP2B | S83 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UDY2 | TJP2 | S978 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGP4 | LIMD1 | S323 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UJF2 | RASAL2 | S891 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UMS6 | SYNPO2 | S322 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMY4 | SNX12 | S27 | ochoa | Sorting nexin-12 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
| Q9UPN3 | MACF1 | S7235 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y2U8 | LEMD3 | S185 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3M2 | CBY1 | S26 | ochoa | Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1) | Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (PubMed:12712206, PubMed:19435523). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (PubMed:15194699). Promotes adipocyte and cardiomyocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9D1C2, ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699, ECO:0000269|PubMed:19435523}. |
| Q9Y4F5 | CEP170B | S954 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5B0 | CTDP1 | S793 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9Y6N7 | ROBO1 | S1081 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| Q9Y6Q9 | NCOA3 | S917 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9UEG4 | ZNF629 | T384 | Sugiyama | Zinc finger protein 629 (Zinc finger protein 65) | May be involved in transcriptional regulation. |
| P12814 | ACTN1 | S797 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| Q6DD87 | ZNF787 | S104 | Sugiyama | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q92888 | ARHGEF1 | S545 | Sugiyama | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| P52742 | ZNF135 | S308 | Sugiyama | Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1) | Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. {ECO:0000269|PubMed:21834987}. |
| P16234 | PDGFRA | S564 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P12830 | CDH1 | S36 | SIGNOR | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| P42684 | ABL2 | S788 | Sugiyama | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| Q9BUG6 | ZSCAN5A | T422 | PSP | Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) | May be involved in transcriptional regulation. |
| Q8N5S9 | CAMKK1 | S57 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000058 | 4.238 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.000033 | 4.482 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.000192 | 3.717 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.000359 | 3.445 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.000369 | 3.433 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.000730 | 3.137 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.000730 | 3.137 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.001397 | 2.855 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.001779 | 2.750 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.001939 | 2.712 |
| R-HSA-446728 | Cell junction organization | 0.002157 | 2.666 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.002192 | 2.659 |
| R-HSA-418990 | Adherens junctions interactions | 0.002466 | 2.608 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.002753 | 2.560 |
| R-HSA-167172 | Transcription of the HIV genome | 0.002884 | 2.540 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.003314 | 2.480 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.003775 | 2.423 |
| R-HSA-1500931 | Cell-Cell communication | 0.004441 | 2.352 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.004583 | 2.339 |
| R-HSA-421270 | Cell-cell junction organization | 0.004987 | 2.302 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 0.007609 | 2.119 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 0.007609 | 2.119 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 0.007609 | 2.119 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 0.007609 | 2.119 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 0.007609 | 2.119 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 0.007609 | 2.119 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.008571 | 2.067 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.014791 | 1.830 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.015970 | 1.797 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.019739 | 1.705 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.018445 | 1.734 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.023113 | 1.636 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.026752 | 1.573 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.026752 | 1.573 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.028259 | 1.549 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.028259 | 1.549 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.028259 | 1.549 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.028259 | 1.549 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.028335 | 1.548 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.029799 | 1.526 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.030095 | 1.522 |
| R-HSA-9918454 | Defective visual phototransduction due to ABCA4 loss of function | 0.030095 | 1.522 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.034926 | 1.457 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.034613 | 1.461 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.036281 | 1.440 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.036854 | 1.434 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.044804 | 1.349 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.059291 | 1.227 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.037979 | 1.420 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.050674 | 1.295 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.050674 | 1.295 |
| R-HSA-167161 | HIV Transcription Initiation | 0.054545 | 1.263 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.054545 | 1.263 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.056519 | 1.248 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.050674 | 1.295 |
| R-HSA-167169 | HIV Transcription Elongation | 0.050674 | 1.295 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.048778 | 1.312 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.058517 | 1.233 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.054545 | 1.263 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.045066 | 1.346 |
| R-HSA-162587 | HIV Life Cycle | 0.045895 | 1.338 |
| R-HSA-447038 | NrCAM interactions | 0.052075 | 1.283 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.059291 | 1.227 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.059291 | 1.227 |
| R-HSA-165159 | MTOR signalling | 0.056519 | 1.248 |
| R-HSA-8854214 | TBC/RABGAPs | 0.058517 | 1.233 |
| R-HSA-1483255 | PI Metabolism | 0.056294 | 1.250 |
| R-HSA-162582 | Signal Transduction | 0.052167 | 1.283 |
| R-HSA-212436 | Generic Transcription Pathway | 0.053874 | 1.269 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.048296 | 1.316 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.073561 | 1.133 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.087616 | 1.057 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.101459 | 0.994 |
| R-HSA-428540 | Activation of RAC1 | 0.108302 | 0.965 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.115094 | 0.939 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.121834 | 0.914 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.135163 | 0.869 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.135163 | 0.869 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.141751 | 0.848 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.077539 | 1.110 |
| R-HSA-429947 | Deadenylation of mRNA | 0.204961 | 0.688 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.079759 | 1.098 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.223007 | 0.652 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.234811 | 0.629 |
| R-HSA-390522 | Striated Muscle Contraction | 0.263549 | 0.579 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.274743 | 0.561 |
| R-HSA-186763 | Downstream signal transduction | 0.246438 | 0.608 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.240646 | 0.619 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.186499 | 0.729 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.062586 | 1.204 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.125236 | 0.902 |
| R-HSA-4641265 | Repression of WNT target genes | 0.115094 | 0.939 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.154780 | 0.810 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.257889 | 0.589 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.068864 | 1.162 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.073561 | 1.133 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.087616 | 1.057 |
| R-HSA-176974 | Unwinding of DNA | 0.087616 | 1.057 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.115094 | 0.939 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.161220 | 0.793 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.263549 | 0.579 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.269167 | 0.570 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.280276 | 0.552 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.233480 | 0.632 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.236291 | 0.627 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.125236 | 0.902 |
| R-HSA-447043 | Neurofascin interactions | 0.066453 | 1.177 |
| R-HSA-182971 | EGFR downregulation | 0.246438 | 0.608 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.073561 | 1.133 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.087616 | 1.057 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.148511 | 0.828 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.186205 | 0.730 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.240646 | 0.619 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.285767 | 0.544 |
| R-HSA-73927 | Depurination | 0.291217 | 0.536 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.080615 | 1.094 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.252185 | 0.598 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.127776 | 0.894 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.121147 | 0.917 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.128524 | 0.891 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.173955 | 0.760 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.240646 | 0.619 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.307320 | 0.512 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.257889 | 0.589 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.104964 | 0.979 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.119489 | 0.923 |
| R-HSA-9664407 | Parasite infection | 0.119489 | 0.923 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.119489 | 0.923 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.135163 | 0.869 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 0.192700 | 0.715 |
| R-HSA-9839394 | TGFBR3 expression | 0.211022 | 0.676 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.130329 | 0.885 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.269167 | 0.570 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.141684 | 0.849 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.250367 | 0.601 |
| R-HSA-162906 | HIV Infection | 0.121559 | 0.915 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.094564 | 1.024 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.211022 | 0.676 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.087826 | 1.056 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.298292 | 0.525 |
| R-HSA-5635838 | Activation of SMO | 0.141751 | 0.848 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.257889 | 0.589 |
| R-HSA-525793 | Myogenesis | 0.217037 | 0.663 |
| R-HSA-983189 | Kinesins | 0.095830 | 1.018 |
| R-HSA-69481 | G2/M Checkpoints | 0.095701 | 1.019 |
| R-HSA-447041 | CHL1 interactions | 0.073561 | 1.133 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.252185 | 0.598 |
| R-HSA-5693538 | Homology Directed Repair | 0.267290 | 0.573 |
| R-HSA-69239 | Synthesis of DNA | 0.230672 | 0.637 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.100580 | 0.997 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.197218 | 0.705 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.256006 | 0.592 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.161220 | 0.793 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.173955 | 0.760 |
| R-HSA-947581 | Molybdenum cofactor biosynthesis | 0.186499 | 0.729 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.183910 | 0.735 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.292616 | 0.534 |
| R-HSA-199991 | Membrane Trafficking | 0.140704 | 0.852 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.223007 | 0.652 |
| R-HSA-69275 | G2/M Transition | 0.207138 | 0.684 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.211074 | 0.676 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.186499 | 0.729 |
| R-HSA-1640170 | Cell Cycle | 0.106579 | 0.972 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.186499 | 0.729 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.274743 | 0.561 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.164344 | 0.784 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.300266 | 0.522 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.307320 | 0.512 |
| R-HSA-422475 | Axon guidance | 0.265159 | 0.576 |
| R-HSA-9834899 | Specification of the neural plate border | 0.167612 | 0.776 |
| R-HSA-69190 | DNA strand elongation | 0.252185 | 0.598 |
| R-HSA-111933 | Calmodulin induced events | 0.280276 | 0.552 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.073561 | 1.133 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.167612 | 0.776 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.192700 | 0.715 |
| R-HSA-112311 | Neurotransmitter clearance | 0.240646 | 0.619 |
| R-HSA-111997 | CaM pathway | 0.280276 | 0.552 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.115094 | 0.939 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.148290 | 0.829 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.269167 | 0.570 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.192700 | 0.715 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.240646 | 0.619 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.121834 | 0.914 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.135163 | 0.869 |
| R-HSA-2028269 | Signaling by Hippo | 0.154780 | 0.810 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.211022 | 0.676 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.211022 | 0.676 |
| R-HSA-73614 | Pyrimidine salvage | 0.228931 | 0.640 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.291217 | 0.536 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.267290 | 0.573 |
| R-HSA-74160 | Gene expression (Transcription) | 0.077645 | 1.110 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.264468 | 0.578 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.141751 | 0.848 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.257889 | 0.589 |
| R-HSA-74217 | Purine salvage | 0.291217 | 0.536 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.258826 | 0.587 |
| R-HSA-373753 | Nephrin family interactions | 0.173955 | 0.760 |
| R-HSA-2453864 | Retinoid cycle disease events | 0.211022 | 0.676 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.307320 | 0.512 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.062685 | 1.203 |
| R-HSA-2474795 | Diseases associated with visual transduction | 0.211022 | 0.676 |
| R-HSA-9675143 | Diseases of the neuronal system | 0.211022 | 0.676 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.217037 | 0.663 |
| R-HSA-3000170 | Syndecan interactions | 0.198853 | 0.701 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.132893 | 0.876 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.299696 | 0.523 |
| R-HSA-9831926 | Nephron development | 0.161220 | 0.793 |
| R-HSA-264876 | Insulin processing | 0.223007 | 0.652 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.198853 | 0.701 |
| R-HSA-9758941 | Gastrulation | 0.136443 | 0.865 |
| R-HSA-75153 | Apoptotic execution phase | 0.064656 | 1.189 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.274743 | 0.561 |
| R-HSA-109581 | Apoptosis | 0.159624 | 0.797 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.307320 | 0.512 |
| R-HSA-9607240 | FLT3 Signaling | 0.307320 | 0.512 |
| R-HSA-5357801 | Programmed Cell Death | 0.247170 | 0.607 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.258826 | 0.587 |
| R-HSA-194138 | Signaling by VEGF | 0.289849 | 0.538 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.312607 | 0.505 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.312607 | 0.505 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.312607 | 0.505 |
| R-HSA-9675108 | Nervous system development | 0.313927 | 0.503 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.317853 | 0.498 |
| R-HSA-111996 | Ca-dependent events | 0.317853 | 0.498 |
| R-HSA-373752 | Netrin-1 signaling | 0.328228 | 0.484 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.331882 | 0.479 |
| R-HSA-1266738 | Developmental Biology | 0.332566 | 0.478 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.333356 | 0.477 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.333356 | 0.477 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.333356 | 0.477 |
| R-HSA-4839726 | Chromatin organization | 0.338247 | 0.471 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.338445 | 0.471 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.338445 | 0.471 |
| R-HSA-9675135 | Diseases of DNA repair | 0.338445 | 0.471 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.343496 | 0.464 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.348509 | 0.458 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.348519 | 0.458 |
| R-HSA-9766229 | Degradation of CDH1 | 0.353484 | 0.452 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.355879 | 0.449 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.358421 | 0.446 |
| R-HSA-166520 | Signaling by NTRKs | 0.362279 | 0.441 |
| R-HSA-69242 | S Phase | 0.362279 | 0.441 |
| R-HSA-9864848 | Complex IV assembly | 0.363321 | 0.440 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.363321 | 0.440 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.368183 | 0.434 |
| R-HSA-913531 | Interferon Signaling | 0.372236 | 0.429 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.373009 | 0.428 |
| R-HSA-1221632 | Meiotic synapsis | 0.373009 | 0.428 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.375933 | 0.425 |
| R-HSA-69306 | DNA Replication | 0.375933 | 0.425 |
| R-HSA-72649 | Translation initiation complex formation | 0.377798 | 0.423 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.377798 | 0.423 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.377798 | 0.423 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.378649 | 0.422 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.378649 | 0.422 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.382551 | 0.417 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.387268 | 0.412 |
| R-HSA-177929 | Signaling by EGFR | 0.387268 | 0.412 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.387268 | 0.412 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.387268 | 0.412 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.391949 | 0.407 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.391949 | 0.407 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.396594 | 0.402 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.396594 | 0.402 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.401205 | 0.397 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.401205 | 0.397 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.404477 | 0.393 |
| R-HSA-9658195 | Leishmania infection | 0.404477 | 0.393 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.405780 | 0.392 |
| R-HSA-379724 | tRNA Aminoacylation | 0.405780 | 0.392 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.405780 | 0.392 |
| R-HSA-112043 | PLC beta mediated events | 0.410321 | 0.387 |
| R-HSA-8956321 | Nucleotide salvage | 0.410321 | 0.387 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.414827 | 0.382 |
| R-HSA-186797 | Signaling by PDGF | 0.414827 | 0.382 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.419300 | 0.377 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.419300 | 0.377 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.428143 | 0.368 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.432514 | 0.364 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.432514 | 0.364 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.432922 | 0.364 |
| R-HSA-1483257 | Phospholipid metabolism | 0.432922 | 0.364 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.436852 | 0.360 |
| R-HSA-112040 | G-protein mediated events | 0.436852 | 0.360 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.436852 | 0.360 |
| R-HSA-9830369 | Kidney development | 0.436852 | 0.360 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.437059 | 0.359 |
| R-HSA-195721 | Signaling by WNT | 0.438956 | 0.358 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.449670 | 0.347 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.453878 | 0.343 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.453878 | 0.343 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.453878 | 0.343 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.457573 | 0.340 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.458054 | 0.339 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.458054 | 0.339 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.462199 | 0.335 |
| R-HSA-4086398 | Ca2+ pathway | 0.462199 | 0.335 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.462199 | 0.335 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.466312 | 0.331 |
| R-HSA-380287 | Centrosome maturation | 0.470393 | 0.328 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.470393 | 0.328 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.470393 | 0.328 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.480133 | 0.319 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.482454 | 0.317 |
| R-HSA-216083 | Integrin cell surface interactions | 0.482454 | 0.317 |
| R-HSA-68877 | Mitotic Prometaphase | 0.482605 | 0.316 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.490342 | 0.310 |
| R-HSA-6806834 | Signaling by MET | 0.490342 | 0.310 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.498112 | 0.303 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.501952 | 0.299 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.505764 | 0.296 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.505764 | 0.296 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.509546 | 0.293 |
| R-HSA-1500620 | Meiosis | 0.509546 | 0.293 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.513300 | 0.290 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.513300 | 0.290 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.513300 | 0.290 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.517025 | 0.286 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.520722 | 0.283 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.520722 | 0.283 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.524391 | 0.280 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.531645 | 0.274 |
| R-HSA-73884 | Base Excision Repair | 0.531645 | 0.274 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.533531 | 0.273 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.538789 | 0.269 |
| R-HSA-68882 | Mitotic Anaphase | 0.539711 | 0.268 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.541995 | 0.266 |
| R-HSA-391251 | Protein folding | 0.542321 | 0.266 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.549304 | 0.260 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.549304 | 0.260 |
| R-HSA-73894 | DNA Repair | 0.557123 | 0.254 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.559581 | 0.252 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.559581 | 0.252 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.562955 | 0.250 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.568799 | 0.245 |
| R-HSA-3214847 | HATs acetylate histones | 0.569625 | 0.244 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.569625 | 0.244 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.572923 | 0.242 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.572923 | 0.242 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.572923 | 0.242 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.579442 | 0.237 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.579442 | 0.237 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.579632 | 0.237 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.585863 | 0.232 |
| R-HSA-111885 | Opioid Signalling | 0.585863 | 0.232 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.589037 | 0.230 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.589037 | 0.230 |
| R-HSA-68886 | M Phase | 0.597092 | 0.224 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.601494 | 0.221 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.601494 | 0.221 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.601494 | 0.221 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.604549 | 0.219 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.613575 | 0.212 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.613575 | 0.212 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.613575 | 0.212 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.616539 | 0.210 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.631020 | 0.200 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.631020 | 0.200 |
| R-HSA-373760 | L1CAM interactions | 0.631020 | 0.200 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.633850 | 0.198 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.638545 | 0.195 |
| R-HSA-68875 | Mitotic Prophase | 0.642213 | 0.192 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.644959 | 0.190 |
| R-HSA-3371556 | Cellular response to heat stress | 0.644959 | 0.190 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.650387 | 0.187 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.650387 | 0.187 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.658375 | 0.182 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.658375 | 0.182 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.658375 | 0.182 |
| R-HSA-69206 | G1/S Transition | 0.658375 | 0.182 |
| R-HSA-114608 | Platelet degranulation | 0.663600 | 0.178 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.671288 | 0.173 |
| R-HSA-1474165 | Reproduction | 0.673812 | 0.171 |
| R-HSA-9843745 | Adipogenesis | 0.676317 | 0.170 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.678803 | 0.168 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.681269 | 0.167 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.685736 | 0.164 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.690950 | 0.161 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.690950 | 0.161 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.697555 | 0.156 |
| R-HSA-6807070 | PTEN Regulation | 0.698018 | 0.156 |
| R-HSA-1632852 | Macroautophagy | 0.702641 | 0.153 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.716093 | 0.145 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.718275 | 0.144 |
| R-HSA-2187338 | Visual phototransduction | 0.718275 | 0.144 |
| R-HSA-9609507 | Protein localization | 0.731026 | 0.136 |
| R-HSA-73887 | Death Receptor Signaling | 0.733094 | 0.135 |
| R-HSA-1989781 | PPARA activates gene expression | 0.735147 | 0.134 |
| R-HSA-9612973 | Autophagy | 0.737184 | 0.132 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.738265 | 0.132 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.739206 | 0.131 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.739763 | 0.131 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.739763 | 0.131 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.745179 | 0.128 |
| R-HSA-1474244 | Extracellular matrix organization | 0.751275 | 0.124 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.752932 | 0.123 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.752932 | 0.123 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.769532 | 0.114 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.771306 | 0.113 |
| R-HSA-611105 | Respiratory electron transport | 0.779979 | 0.108 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.780304 | 0.108 |
| R-HSA-2559583 | Cellular Senescence | 0.783356 | 0.106 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.793181 | 0.101 |
| R-HSA-983712 | Ion channel transport | 0.797926 | 0.098 |
| R-HSA-5617833 | Cilium Assembly | 0.799484 | 0.097 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.805597 | 0.094 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.814421 | 0.089 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.817273 | 0.088 |
| R-HSA-72172 | mRNA Splicing | 0.821470 | 0.085 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.824462 | 0.084 |
| R-HSA-397014 | Muscle contraction | 0.832200 | 0.080 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.832200 | 0.080 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.849460 | 0.071 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.854060 | 0.069 |
| R-HSA-15869 | Metabolism of nucleotides | 0.860700 | 0.065 |
| R-HSA-72766 | Translation | 0.861118 | 0.065 |
| R-HSA-8939211 | ESR-mediated signaling | 0.861777 | 0.065 |
| R-HSA-157118 | Signaling by NOTCH | 0.864958 | 0.063 |
| R-HSA-5688426 | Deubiquitination | 0.879810 | 0.056 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.880741 | 0.055 |
| R-HSA-6798695 | Neutrophil degranulation | 0.882998 | 0.054 |
| R-HSA-112316 | Neuronal System | 0.890695 | 0.050 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.891364 | 0.050 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.896317 | 0.048 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.900274 | 0.046 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.902576 | 0.045 |
| R-HSA-5663205 | Infectious disease | 0.915940 | 0.038 |
| R-HSA-168256 | Immune System | 0.921974 | 0.035 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.927549 | 0.033 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.938506 | 0.028 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.948224 | 0.023 |
| R-HSA-109582 | Hemostasis | 0.948534 | 0.023 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.948628 | 0.023 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.956074 | 0.020 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.959703 | 0.018 |
| R-HSA-449147 | Signaling by Interleukins | 0.960091 | 0.018 |
| R-HSA-2262752 | Cellular responses to stress | 0.960472 | 0.018 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.960639 | 0.017 |
| R-HSA-1643685 | Disease | 0.962890 | 0.016 |
| R-HSA-418594 | G alpha (i) signalling events | 0.963609 | 0.016 |
| R-HSA-1280218 | Adaptive Immune System | 0.966123 | 0.015 |
| R-HSA-372790 | Signaling by GPCR | 0.966571 | 0.015 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.967652 | 0.014 |
| R-HSA-9824446 | Viral Infection Pathways | 0.978548 | 0.009 |
| R-HSA-168249 | Innate Immune System | 0.980162 | 0.009 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.980659 | 0.008 |
| R-HSA-392499 | Metabolism of proteins | 0.984198 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.984389 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.985413 | 0.006 |
| R-HSA-8953854 | Metabolism of RNA | 0.990448 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.991023 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.991348 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.993129 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.997624 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999955 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.857 | 0.184 | 2 | 0.822 |
CLK3 |
0.853 | 0.252 | 1 | 0.801 |
PIM3 |
0.852 | 0.211 | -3 | 0.811 |
MOS |
0.846 | 0.157 | 1 | 0.839 |
NDR2 |
0.846 | 0.142 | -3 | 0.819 |
CDC7 |
0.846 | 0.067 | 1 | 0.791 |
MTOR |
0.845 | 0.059 | 1 | 0.780 |
HIPK4 |
0.844 | 0.213 | 1 | 0.812 |
SKMLCK |
0.843 | 0.227 | -2 | 0.860 |
CDKL1 |
0.842 | 0.164 | -3 | 0.771 |
PRKD1 |
0.842 | 0.167 | -3 | 0.797 |
CDKL5 |
0.841 | 0.195 | -3 | 0.765 |
SRPK1 |
0.841 | 0.168 | -3 | 0.735 |
NLK |
0.840 | 0.100 | 1 | 0.813 |
RAF1 |
0.839 | 0.028 | 1 | 0.815 |
PIM1 |
0.839 | 0.169 | -3 | 0.769 |
IKKB |
0.839 | -0.008 | -2 | 0.735 |
ATR |
0.838 | 0.097 | 1 | 0.831 |
ERK5 |
0.838 | 0.112 | 1 | 0.787 |
ICK |
0.837 | 0.215 | -3 | 0.807 |
PRPK |
0.837 | -0.063 | -1 | 0.769 |
RIPK3 |
0.837 | 0.114 | 3 | 0.723 |
PRKD2 |
0.836 | 0.126 | -3 | 0.759 |
NUAK2 |
0.835 | 0.090 | -3 | 0.827 |
TBK1 |
0.835 | 0.001 | 1 | 0.707 |
WNK1 |
0.835 | 0.094 | -2 | 0.865 |
MLK1 |
0.834 | 0.067 | 2 | 0.797 |
GRK1 |
0.834 | 0.128 | -2 | 0.813 |
NDR1 |
0.834 | 0.058 | -3 | 0.811 |
CAMK1B |
0.833 | 0.030 | -3 | 0.834 |
RSK2 |
0.833 | 0.098 | -3 | 0.762 |
CHAK2 |
0.833 | 0.062 | -1 | 0.775 |
GCN2 |
0.832 | -0.132 | 2 | 0.786 |
PDHK4 |
0.832 | -0.174 | 1 | 0.831 |
LATS2 |
0.832 | 0.070 | -5 | 0.722 |
PKCD |
0.832 | 0.124 | 2 | 0.778 |
NIK |
0.831 | 0.073 | -3 | 0.845 |
IRE1 |
0.831 | 0.124 | 1 | 0.820 |
MLK3 |
0.831 | 0.128 | 2 | 0.738 |
GRK5 |
0.831 | -0.028 | -3 | 0.825 |
BMPR2 |
0.831 | -0.092 | -2 | 0.852 |
NEK6 |
0.831 | -0.021 | -2 | 0.803 |
DSTYK |
0.831 | -0.039 | 2 | 0.841 |
MST4 |
0.831 | 0.060 | 2 | 0.834 |
DYRK2 |
0.830 | 0.145 | 1 | 0.705 |
KIS |
0.830 | 0.085 | 1 | 0.673 |
PKN3 |
0.830 | 0.051 | -3 | 0.790 |
IKKA |
0.830 | 0.030 | -2 | 0.730 |
MLK2 |
0.830 | 0.092 | 2 | 0.793 |
PKN2 |
0.830 | 0.083 | -3 | 0.817 |
P90RSK |
0.829 | 0.073 | -3 | 0.755 |
IKKE |
0.829 | -0.044 | 1 | 0.692 |
AURC |
0.829 | 0.127 | -2 | 0.661 |
HIPK2 |
0.829 | 0.174 | 1 | 0.624 |
CDK18 |
0.829 | 0.160 | 1 | 0.604 |
CAMLCK |
0.829 | 0.072 | -2 | 0.847 |
MARK4 |
0.829 | 0.036 | 4 | 0.807 |
PKCA |
0.828 | 0.150 | 2 | 0.734 |
MAPKAPK3 |
0.828 | 0.049 | -3 | 0.749 |
PDHK1 |
0.828 | -0.134 | 1 | 0.809 |
ULK2 |
0.828 | -0.130 | 2 | 0.753 |
DAPK2 |
0.827 | 0.076 | -3 | 0.838 |
AMPKA1 |
0.827 | 0.056 | -3 | 0.833 |
SRPK2 |
0.827 | 0.114 | -3 | 0.656 |
TGFBR2 |
0.827 | -0.025 | -2 | 0.750 |
TSSK1 |
0.827 | 0.108 | -3 | 0.855 |
MAPKAPK2 |
0.827 | 0.081 | -3 | 0.708 |
BCKDK |
0.827 | -0.051 | -1 | 0.717 |
PKCZ |
0.826 | 0.129 | 2 | 0.766 |
MPSK1 |
0.826 | 0.339 | 1 | 0.862 |
HUNK |
0.826 | -0.044 | 2 | 0.756 |
TSSK2 |
0.825 | 0.073 | -5 | 0.825 |
CAMK2G |
0.825 | -0.084 | 2 | 0.765 |
PKCB |
0.825 | 0.108 | 2 | 0.738 |
CDK7 |
0.825 | 0.085 | 1 | 0.664 |
IRE2 |
0.825 | 0.119 | 2 | 0.737 |
CAMK2D |
0.825 | 0.012 | -3 | 0.806 |
CDK8 |
0.824 | 0.085 | 1 | 0.644 |
NEK7 |
0.824 | -0.122 | -3 | 0.787 |
PKCG |
0.824 | 0.101 | 2 | 0.732 |
AMPKA2 |
0.823 | 0.054 | -3 | 0.805 |
CDK19 |
0.823 | 0.103 | 1 | 0.609 |
HIPK1 |
0.823 | 0.153 | 1 | 0.726 |
PKACG |
0.823 | 0.047 | -2 | 0.727 |
LATS1 |
0.823 | 0.132 | -3 | 0.827 |
NEK9 |
0.823 | -0.047 | 2 | 0.811 |
RIPK1 |
0.822 | -0.025 | 1 | 0.815 |
CAMK2A |
0.822 | 0.087 | 2 | 0.770 |
SRPK3 |
0.822 | 0.107 | -3 | 0.697 |
CDK5 |
0.822 | 0.121 | 1 | 0.689 |
WNK3 |
0.822 | -0.107 | 1 | 0.801 |
RSK3 |
0.821 | 0.035 | -3 | 0.741 |
MASTL |
0.821 | -0.122 | -2 | 0.814 |
QSK |
0.821 | 0.064 | 4 | 0.787 |
CDK1 |
0.821 | 0.099 | 1 | 0.625 |
ERK1 |
0.821 | 0.131 | 1 | 0.612 |
DLK |
0.821 | -0.063 | 1 | 0.792 |
PHKG1 |
0.821 | 0.036 | -3 | 0.808 |
JNK2 |
0.820 | 0.117 | 1 | 0.603 |
PKR |
0.820 | 0.114 | 1 | 0.845 |
P38A |
0.820 | 0.146 | 1 | 0.695 |
P38B |
0.820 | 0.154 | 1 | 0.615 |
GRK6 |
0.820 | -0.028 | 1 | 0.794 |
BMPR1B |
0.820 | 0.095 | 1 | 0.747 |
CLK4 |
0.819 | 0.102 | -3 | 0.762 |
PKACB |
0.819 | 0.117 | -2 | 0.662 |
RSK4 |
0.819 | 0.099 | -3 | 0.733 |
CLK2 |
0.819 | 0.182 | -3 | 0.743 |
MNK1 |
0.819 | 0.102 | -2 | 0.793 |
MNK2 |
0.819 | 0.066 | -2 | 0.784 |
CDK13 |
0.819 | 0.063 | 1 | 0.639 |
ATM |
0.819 | 0.018 | 1 | 0.769 |
PAK1 |
0.819 | 0.056 | -2 | 0.805 |
MELK |
0.819 | 0.035 | -3 | 0.789 |
PRKX |
0.818 | 0.136 | -3 | 0.696 |
GRK7 |
0.818 | 0.070 | 1 | 0.744 |
P70S6KB |
0.818 | 0.004 | -3 | 0.775 |
CAMK4 |
0.818 | -0.015 | -3 | 0.802 |
CDK17 |
0.818 | 0.105 | 1 | 0.548 |
QIK |
0.818 | -0.010 | -3 | 0.811 |
MSK2 |
0.818 | 0.030 | -3 | 0.715 |
PRKD3 |
0.818 | 0.046 | -3 | 0.732 |
ANKRD3 |
0.817 | -0.077 | 1 | 0.827 |
JNK3 |
0.817 | 0.089 | 1 | 0.635 |
NIM1 |
0.817 | -0.052 | 3 | 0.767 |
NUAK1 |
0.817 | 0.018 | -3 | 0.765 |
SMG1 |
0.816 | 0.005 | 1 | 0.797 |
MLK4 |
0.816 | 0.039 | 2 | 0.713 |
CAMK2B |
0.816 | 0.034 | 2 | 0.730 |
PAK3 |
0.816 | 0.017 | -2 | 0.799 |
AURB |
0.816 | 0.084 | -2 | 0.657 |
GRK4 |
0.816 | -0.100 | -2 | 0.804 |
CDK14 |
0.816 | 0.134 | 1 | 0.652 |
YSK4 |
0.815 | -0.005 | 1 | 0.747 |
DYRK1A |
0.815 | 0.131 | 1 | 0.721 |
CHAK1 |
0.815 | -0.010 | 2 | 0.746 |
MYLK4 |
0.815 | 0.065 | -2 | 0.768 |
SIK |
0.815 | 0.029 | -3 | 0.742 |
PIM2 |
0.815 | 0.105 | -3 | 0.732 |
CLK1 |
0.814 | 0.098 | -3 | 0.742 |
CK1E |
0.814 | 0.090 | -3 | 0.604 |
ULK1 |
0.814 | -0.208 | -3 | 0.741 |
MSK1 |
0.814 | 0.073 | -3 | 0.717 |
PKCH |
0.814 | 0.045 | 2 | 0.723 |
P38G |
0.813 | 0.096 | 1 | 0.533 |
BRSK1 |
0.812 | 0.021 | -3 | 0.767 |
CDK12 |
0.812 | 0.061 | 1 | 0.608 |
PKG2 |
0.812 | 0.071 | -2 | 0.660 |
DNAPK |
0.812 | 0.062 | 1 | 0.716 |
MAK |
0.812 | 0.274 | -2 | 0.861 |
VRK2 |
0.812 | -0.028 | 1 | 0.852 |
AKT2 |
0.812 | 0.077 | -3 | 0.687 |
CDK10 |
0.812 | 0.128 | 1 | 0.640 |
NEK2 |
0.812 | -0.031 | 2 | 0.796 |
CDK9 |
0.811 | 0.033 | 1 | 0.644 |
ERK2 |
0.811 | 0.056 | 1 | 0.661 |
MARK3 |
0.811 | 0.037 | 4 | 0.741 |
HIPK3 |
0.811 | 0.103 | 1 | 0.707 |
DYRK1B |
0.811 | 0.105 | 1 | 0.649 |
ALK4 |
0.810 | -0.042 | -2 | 0.798 |
P38D |
0.810 | 0.135 | 1 | 0.559 |
DYRK4 |
0.810 | 0.117 | 1 | 0.620 |
BRSK2 |
0.810 | -0.020 | -3 | 0.792 |
PAK2 |
0.810 | 0.006 | -2 | 0.792 |
PRP4 |
0.810 | 0.101 | -3 | 0.765 |
FAM20C |
0.810 | -0.014 | 2 | 0.510 |
MST3 |
0.809 | 0.101 | 2 | 0.820 |
TTBK2 |
0.809 | -0.161 | 2 | 0.642 |
CDK3 |
0.809 | 0.081 | 1 | 0.566 |
TGFBR1 |
0.809 | -0.004 | -2 | 0.768 |
DYRK3 |
0.808 | 0.116 | 1 | 0.731 |
DCAMKL1 |
0.808 | 0.041 | -3 | 0.781 |
CHK1 |
0.808 | 0.020 | -3 | 0.782 |
CDK16 |
0.808 | 0.120 | 1 | 0.571 |
NEK5 |
0.808 | 0.051 | 1 | 0.831 |
TLK2 |
0.807 | -0.045 | 1 | 0.801 |
SGK3 |
0.807 | 0.046 | -3 | 0.749 |
IRAK4 |
0.807 | 0.034 | 1 | 0.805 |
MEK1 |
0.807 | -0.163 | 2 | 0.789 |
MARK2 |
0.807 | 0.003 | 4 | 0.704 |
PAK6 |
0.807 | 0.045 | -2 | 0.726 |
ALK2 |
0.806 | -0.005 | -2 | 0.777 |
MEKK1 |
0.806 | -0.018 | 1 | 0.779 |
TAO3 |
0.806 | 0.075 | 1 | 0.770 |
PASK |
0.806 | 0.105 | -3 | 0.829 |
CAMK1G |
0.806 | 0.009 | -3 | 0.739 |
WNK4 |
0.806 | -0.015 | -2 | 0.862 |
PKCT |
0.805 | 0.048 | 2 | 0.727 |
PLK1 |
0.805 | -0.115 | -2 | 0.751 |
AURA |
0.805 | 0.058 | -2 | 0.639 |
CK1D |
0.805 | 0.083 | -3 | 0.556 |
PERK |
0.805 | -0.082 | -2 | 0.790 |
ERK7 |
0.805 | 0.119 | 2 | 0.587 |
SNRK |
0.804 | -0.117 | 2 | 0.640 |
ACVR2B |
0.804 | -0.029 | -2 | 0.749 |
MEKK3 |
0.804 | -0.056 | 1 | 0.774 |
MEK5 |
0.804 | -0.103 | 2 | 0.789 |
SSTK |
0.804 | 0.044 | 4 | 0.787 |
MEKK2 |
0.804 | -0.007 | 2 | 0.776 |
DRAK1 |
0.804 | -0.029 | 1 | 0.740 |
PINK1 |
0.804 | -0.059 | 1 | 0.864 |
ACVR2A |
0.804 | -0.044 | -2 | 0.737 |
MARK1 |
0.803 | -0.006 | 4 | 0.765 |
GRK2 |
0.803 | -0.041 | -2 | 0.696 |
GAK |
0.803 | 0.205 | 1 | 0.879 |
PKCI |
0.802 | 0.053 | 2 | 0.744 |
MOK |
0.802 | 0.205 | 1 | 0.761 |
PKACA |
0.802 | 0.080 | -2 | 0.610 |
PKCE |
0.802 | 0.096 | 2 | 0.725 |
AKT1 |
0.802 | 0.075 | -3 | 0.706 |
CDK2 |
0.802 | -0.027 | 1 | 0.701 |
GCK |
0.801 | 0.133 | 1 | 0.788 |
BRAF |
0.801 | -0.082 | -4 | 0.825 |
HRI |
0.801 | -0.121 | -2 | 0.802 |
ZAK |
0.800 | -0.095 | 1 | 0.734 |
CK1G1 |
0.799 | 0.024 | -3 | 0.583 |
PHKG2 |
0.798 | 0.012 | -3 | 0.794 |
SMMLCK |
0.798 | 0.020 | -3 | 0.789 |
GSK3A |
0.798 | 0.056 | 4 | 0.444 |
LKB1 |
0.798 | 0.012 | -3 | 0.791 |
BMPR1A |
0.797 | 0.026 | 1 | 0.714 |
CK1A2 |
0.797 | 0.058 | -3 | 0.559 |
CDK6 |
0.797 | 0.094 | 1 | 0.628 |
NEK11 |
0.797 | -0.056 | 1 | 0.765 |
CDK4 |
0.797 | 0.086 | 1 | 0.601 |
PLK3 |
0.797 | -0.129 | 2 | 0.710 |
NEK8 |
0.796 | -0.062 | 2 | 0.798 |
TAO2 |
0.796 | 0.023 | 2 | 0.821 |
CAMK1D |
0.795 | 0.025 | -3 | 0.674 |
HPK1 |
0.795 | 0.098 | 1 | 0.770 |
TNIK |
0.794 | 0.092 | 3 | 0.810 |
MAPKAPK5 |
0.794 | -0.126 | -3 | 0.675 |
KHS1 |
0.794 | 0.150 | 1 | 0.764 |
DCAMKL2 |
0.794 | -0.035 | -3 | 0.800 |
PAK5 |
0.794 | 0.027 | -2 | 0.688 |
DAPK3 |
0.794 | 0.074 | -3 | 0.787 |
KHS2 |
0.793 | 0.154 | 1 | 0.782 |
CAMKK1 |
0.793 | -0.101 | -2 | 0.751 |
EEF2K |
0.793 | 0.069 | 3 | 0.777 |
PLK4 |
0.793 | -0.147 | 2 | 0.571 |
HGK |
0.793 | 0.054 | 3 | 0.803 |
PDK1 |
0.793 | -0.019 | 1 | 0.764 |
BUB1 |
0.792 | 0.129 | -5 | 0.759 |
CAMKK2 |
0.792 | -0.082 | -2 | 0.753 |
SLK |
0.792 | 0.041 | -2 | 0.727 |
TLK1 |
0.792 | -0.139 | -2 | 0.780 |
MST2 |
0.792 | -0.012 | 1 | 0.779 |
LRRK2 |
0.792 | 0.020 | 2 | 0.816 |
MINK |
0.792 | 0.053 | 1 | 0.775 |
ROCK2 |
0.792 | 0.109 | -3 | 0.776 |
GSK3B |
0.791 | -0.009 | 4 | 0.438 |
PKN1 |
0.791 | 0.027 | -3 | 0.712 |
TAK1 |
0.791 | 0.023 | 1 | 0.813 |
CHK2 |
0.791 | 0.035 | -3 | 0.638 |
NEK4 |
0.790 | -0.046 | 1 | 0.787 |
JNK1 |
0.789 | 0.039 | 1 | 0.592 |
MEKK6 |
0.789 | -0.020 | 1 | 0.764 |
GRK3 |
0.789 | -0.036 | -2 | 0.654 |
P70S6K |
0.789 | -0.046 | -3 | 0.683 |
LOK |
0.789 | 0.021 | -2 | 0.768 |
MAP3K15 |
0.788 | -0.010 | 1 | 0.726 |
AKT3 |
0.788 | 0.059 | -3 | 0.626 |
PAK4 |
0.788 | 0.019 | -2 | 0.693 |
PBK |
0.787 | 0.141 | 1 | 0.809 |
NEK1 |
0.787 | 0.010 | 1 | 0.796 |
DAPK1 |
0.786 | 0.047 | -3 | 0.772 |
CK2A2 |
0.786 | 0.020 | 1 | 0.660 |
SGK1 |
0.785 | 0.048 | -3 | 0.605 |
MRCKA |
0.784 | 0.043 | -3 | 0.738 |
MRCKB |
0.784 | 0.050 | -3 | 0.725 |
IRAK1 |
0.784 | -0.213 | -1 | 0.679 |
CAMK1A |
0.784 | 0.024 | -3 | 0.645 |
VRK1 |
0.783 | -0.037 | 2 | 0.781 |
MST1 |
0.783 | -0.034 | 1 | 0.765 |
SBK |
0.782 | 0.040 | -3 | 0.570 |
TTBK1 |
0.781 | -0.202 | 2 | 0.565 |
DMPK1 |
0.781 | 0.117 | -3 | 0.760 |
YSK1 |
0.781 | -0.009 | 2 | 0.798 |
TTK |
0.777 | 0.051 | -2 | 0.767 |
HASPIN |
0.777 | 0.031 | -1 | 0.601 |
ROCK1 |
0.777 | 0.073 | -3 | 0.741 |
MYO3B |
0.777 | 0.090 | 2 | 0.806 |
STK33 |
0.777 | -0.132 | 2 | 0.575 |
CK2A1 |
0.776 | 0.006 | 1 | 0.635 |
RIPK2 |
0.774 | -0.215 | 1 | 0.696 |
OSR1 |
0.774 | -0.023 | 2 | 0.779 |
BIKE |
0.773 | 0.150 | 1 | 0.800 |
PLK2 |
0.772 | -0.087 | -3 | 0.705 |
PDHK3_TYR |
0.772 | 0.300 | 4 | 0.877 |
CK1A |
0.769 | 0.040 | -3 | 0.474 |
PKG1 |
0.769 | -0.005 | -2 | 0.576 |
PDHK4_TYR |
0.769 | 0.225 | 2 | 0.842 |
MEK2 |
0.769 | -0.258 | 2 | 0.758 |
TAO1 |
0.768 | -0.006 | 1 | 0.696 |
CRIK |
0.768 | 0.024 | -3 | 0.695 |
MYO3A |
0.767 | 0.015 | 1 | 0.784 |
NEK3 |
0.767 | -0.135 | 1 | 0.724 |
ASK1 |
0.765 | -0.068 | 1 | 0.713 |
TESK1_TYR |
0.764 | 0.103 | 3 | 0.823 |
MAP2K4_TYR |
0.761 | 0.070 | -1 | 0.781 |
MAP2K6_TYR |
0.761 | 0.090 | -1 | 0.792 |
LIMK2_TYR |
0.761 | 0.129 | -3 | 0.851 |
PKMYT1_TYR |
0.759 | 0.056 | 3 | 0.789 |
PDHK1_TYR |
0.759 | 0.091 | -1 | 0.796 |
AAK1 |
0.758 | 0.184 | 1 | 0.712 |
YANK3 |
0.757 | -0.074 | 2 | 0.355 |
MAP2K7_TYR |
0.756 | -0.079 | 2 | 0.813 |
ALPHAK3 |
0.755 | -0.099 | -1 | 0.679 |
PINK1_TYR |
0.754 | -0.070 | 1 | 0.826 |
BMPR2_TYR |
0.752 | -0.023 | -1 | 0.767 |
LIMK1_TYR |
0.750 | -0.057 | 2 | 0.809 |
STLK3 |
0.750 | -0.162 | 1 | 0.708 |
CK1G3 |
0.749 | 0.031 | -3 | 0.428 |
FGR |
0.748 | 0.065 | 1 | 0.835 |
RET |
0.748 | -0.047 | 1 | 0.771 |
ROS1 |
0.746 | -0.012 | 3 | 0.724 |
CSF1R |
0.746 | 0.004 | 3 | 0.734 |
ABL2 |
0.745 | 0.024 | -1 | 0.714 |
TNK2 |
0.745 | 0.056 | 3 | 0.697 |
TYK2 |
0.745 | -0.091 | 1 | 0.766 |
MST1R |
0.744 | -0.072 | 3 | 0.754 |
EPHA6 |
0.744 | -0.014 | -1 | 0.747 |
EPHB4 |
0.743 | -0.014 | -1 | 0.730 |
LCK |
0.743 | 0.094 | -1 | 0.733 |
TNNI3K_TYR |
0.743 | 0.053 | 1 | 0.770 |
TXK |
0.743 | 0.064 | 1 | 0.772 |
TYRO3 |
0.742 | -0.089 | 3 | 0.744 |
YES1 |
0.742 | 0.013 | -1 | 0.750 |
JAK2 |
0.741 | -0.096 | 1 | 0.749 |
ABL1 |
0.741 | 0.001 | -1 | 0.705 |
BLK |
0.740 | 0.114 | -1 | 0.728 |
JAK3 |
0.740 | -0.066 | 1 | 0.744 |
TNK1 |
0.738 | -0.009 | 3 | 0.733 |
HCK |
0.738 | -0.019 | -1 | 0.728 |
WEE1_TYR |
0.738 | 0.015 | -1 | 0.669 |
JAK1 |
0.737 | 0.014 | 1 | 0.703 |
NEK10_TYR |
0.737 | -0.058 | 1 | 0.665 |
KDR |
0.737 | -0.029 | 3 | 0.711 |
DDR1 |
0.736 | -0.156 | 4 | 0.799 |
FER |
0.734 | -0.143 | 1 | 0.813 |
ITK |
0.734 | -0.035 | -1 | 0.711 |
KIT |
0.733 | -0.092 | 3 | 0.724 |
INSRR |
0.732 | -0.109 | 3 | 0.696 |
MET |
0.732 | -0.056 | 3 | 0.726 |
SRMS |
0.732 | -0.093 | 1 | 0.787 |
FLT3 |
0.730 | -0.131 | 3 | 0.746 |
PDGFRB |
0.730 | -0.163 | 3 | 0.742 |
FYN |
0.730 | 0.038 | -1 | 0.706 |
FLT1 |
0.730 | -0.060 | -1 | 0.752 |
EPHA4 |
0.729 | -0.101 | 2 | 0.713 |
EPHB3 |
0.728 | -0.101 | -1 | 0.718 |
FGFR2 |
0.728 | -0.163 | 3 | 0.735 |
MERTK |
0.727 | -0.087 | 3 | 0.734 |
AXL |
0.727 | -0.121 | 3 | 0.729 |
EPHB1 |
0.726 | -0.143 | 1 | 0.768 |
BMX |
0.726 | -0.066 | -1 | 0.609 |
EPHB2 |
0.725 | -0.106 | -1 | 0.707 |
PDGFRA |
0.725 | -0.188 | 3 | 0.736 |
YANK2 |
0.725 | -0.099 | 2 | 0.374 |
PTK6 |
0.725 | -0.176 | -1 | 0.666 |
BTK |
0.724 | -0.171 | -1 | 0.688 |
TEC |
0.724 | -0.109 | -1 | 0.625 |
FGFR1 |
0.723 | -0.193 | 3 | 0.712 |
LYN |
0.723 | -0.065 | 3 | 0.666 |
TEK |
0.722 | -0.200 | 3 | 0.674 |
FRK |
0.721 | -0.100 | -1 | 0.733 |
CK1G2 |
0.720 | -0.012 | -3 | 0.510 |
EPHA7 |
0.719 | -0.108 | 2 | 0.714 |
SRC |
0.719 | -0.037 | -1 | 0.699 |
DDR2 |
0.719 | -0.043 | 3 | 0.664 |
ERBB2 |
0.719 | -0.179 | 1 | 0.719 |
EPHA1 |
0.719 | -0.122 | 3 | 0.709 |
ALK |
0.718 | -0.199 | 3 | 0.645 |
FGFR3 |
0.718 | -0.165 | 3 | 0.711 |
NTRK1 |
0.718 | -0.228 | -1 | 0.733 |
FLT4 |
0.718 | -0.186 | 3 | 0.697 |
EPHA3 |
0.717 | -0.173 | 2 | 0.685 |
LTK |
0.716 | -0.209 | 3 | 0.664 |
NTRK2 |
0.715 | -0.229 | 3 | 0.709 |
INSR |
0.715 | -0.178 | 3 | 0.684 |
MATK |
0.715 | -0.140 | -1 | 0.653 |
NTRK3 |
0.714 | -0.164 | -1 | 0.690 |
PTK2 |
0.713 | -0.017 | -1 | 0.686 |
CSK |
0.712 | -0.145 | 2 | 0.717 |
EPHA5 |
0.711 | -0.128 | 2 | 0.694 |
EGFR |
0.710 | -0.122 | 1 | 0.620 |
PTK2B |
0.710 | -0.139 | -1 | 0.659 |
EPHA8 |
0.710 | -0.131 | -1 | 0.701 |
SYK |
0.709 | -0.042 | -1 | 0.682 |
FGFR4 |
0.705 | -0.149 | -1 | 0.678 |
MUSK |
0.703 | -0.162 | 1 | 0.624 |
ERBB4 |
0.702 | -0.080 | 1 | 0.642 |
EPHA2 |
0.698 | -0.143 | -1 | 0.668 |
IGF1R |
0.696 | -0.204 | 3 | 0.623 |
ZAP70 |
0.694 | -0.045 | -1 | 0.598 |
FES |
0.683 | -0.211 | -1 | 0.591 |