Motif 252 (n=110)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087X0R7 | SENP3-EIF4A1 | S99 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
| A0A0C4DFX4 | None | S2625 | ochoa | Snf2 related CREBBP activator protein | None |
| A1L170 | C1orf226 | S249 | ochoa | Uncharacterized protein C1orf226 | None |
| K7EQG2 | None | S98 | ochoa | Uncharacterized protein | None |
| O60762 | DPM1 | S21 | ochoa | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. {ECO:0000269|PubMed:10835346}. |
| O75674 | TOM1L1 | S321 | ochoa | TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1) | Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}. |
| O75746 | SLC25A12 | S312 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:38945283}. |
| O94868 | FCHSD2 | S693 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O95613 | PCNT | S2352 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S3274 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95863 | SNAI1 | S82 | psp | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| O95900 | TRUB2 | S299 | ochoa | Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25) | Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:33023933}. |
| P06401 | PGR | S20 | ochoa | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P20393 | NR1D1 | S322 | ochoa | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
| P22736 | NR4A1 | S152 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P35712 | SOX6 | S454 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P35712 | SOX6 | S466 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P36956 | SREBF1 | S117 | ochoa|psp | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P41440 | SLC19A1 | S485 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
| P42694 | HELZ | S1247 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P42858 | HTT | S2421 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46937 | YAP1 | S109 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48436 | SOX9 | S223 | ochoa | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P48637 | GSS | S149 | ochoa | Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) | Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7646467, ECO:0000269|PubMed:9215686, ECO:0000303|PubMed:10369661}. |
| P51610 | HCFC1 | S1902 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P52333 | JAK3 | S20 | ochoa | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P57057 | SLC37A1 | S293 | ochoa | Glucose-6-phosphate exchanger SLC37A1 (Glycerol-3-phosphate permease) (G-3-P permease) (Solute carrier family 37 member 1) | Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. {ECO:0000269|PubMed:21949678}. |
| P78314 | SH3BP2 | S416 | ochoa | SH3 domain-binding protein 2 (3BP-2) | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. |
| Q01484 | ANK2 | S1891 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q03164 | KMT2A | S3527 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03252 | LMNB2 | S553 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q05D32 | CTDSPL2 | S146 | ochoa | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q06413 | MEF2C | S240 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q07912 | TNK2 | S102 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08AD1 | CAMSAP2 | S611 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S5430 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5653 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13207 | TBX2 | S401 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13428 | TCOF1 | S1257 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13459 | MYO9B | S1276 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13470 | TNK1 | S500 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q14153 | FAM53B | S179 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q14160 | SCRIB | S1232 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14766 | LTBP1 | S501 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14814 | MEF2D | S192 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15365 | PCBP1 | S202 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15742 | NAB2 | S171 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15942 | ZYX | S303 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q53ET0 | CRTC2 | S183 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5JTC6 | AMER1 | S430 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5PRF9 | SAMD4B | S252 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5T5P2 | KIAA1217 | S1806 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TGY3 | AHDC1 | S1458 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VV67 | PPRC1 | S548 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q63HR2 | TNS2 | S902 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q659A1 | ICE2 | S614 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q66K74 | MAP1S | S655 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6AI39 | BICRAL | S687 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6BDS2 | BLTP3A | S444 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6PKG0 | LARP1 | S1040 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UB99 | ANKRD11 | S1847 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6ZRS2 | SRCAP | S2802 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7L2J0 | MEPCE | S300 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7RTP6 | MICAL3 | S1371 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2K8 | GPRIN1 | S82 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z4K8 | TRIM46 | S88 | ochoa | Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}. |
| Q8IVB4 | SLC9A9 | S612 | ochoa | Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:15522866, PubMed:24065030, PubMed:28130443). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (PubMed:28130443). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity). {ECO:0000250|UniProtKB:Q8BZ00, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443, ECO:0000305|PubMed:15522866}. |
| Q8IWC1 | MAP7D3 | S533 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX07 | ZFPM1 | S384 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY67 | RAVER1 | S524 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IYB3 | SRRM1 | S665 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZP0 | ABI1 | S225 | ochoa|psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N111 | CEND1 | S108 | ochoa | Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen) | Involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9JKC6}. |
| Q8NDX1 | PSD4 | S143 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFQ8 | TOR1AIP2 | S93 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NHG8 | ZNRF2 | S89 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAD8 | SNIP1 | S35 | ochoa|psp | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TF76 | HASPIN | S147 | ochoa|psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUF5 | PPP1R13L | Y132 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WXI9 | GATAD2B | S223 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q8WXX7 | AUTS2 | S1198 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q96AG3 | SLC25A46 | S61 | ochoa | Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) | Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}. |
| Q96AV8 | E2F7 | S638 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96B97 | SH3KBP1 | S436 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96EB6 | SIRT1 | S26 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96PC5 | MIA2 | S1156 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q99650 | OSMR | S889 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Q9BRD0 | BUD13 | S311 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTC0 | DIDO1 | S1714 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9C0C2 | TNKS1BP1 | S287 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1K0 | RBSN | S592 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H2E6 | SEMA6A | S808 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H4L4 | SENP3 | S169 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H7D0 | DOCK5 | S1775 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9HBL0 | TNS1 | S1413 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9P246 | STIM2 | S621 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2J2 | IGSF9 | S809 | ochoa | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}. |
| Q9P2S5 | WRAP73 | S281 | ochoa | WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) | The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. |
| Q9ULL1 | PLEKHG1 | S1341 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UQ35 | SRRM2 | S2394 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y242 | TCF19 | S193 | ochoa | Transcription factor 19 (TCF-19) (Transcription factor SC1) | Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition (PubMed:1868030, PubMed:31141247). May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1 (PubMed:31141247). {ECO:0000269|PubMed:1868030, ECO:0000269|PubMed:31141247}. |
| Q9Y2F5 | ICE1 | S1331 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K7 | KDM2A | S740 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y3B2 | EXOSC1 | S21 | ochoa | Exosome complex component CSL4 (Exosome component 1) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8. |
| Q9Y4B5 | MTCL1 | S685 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4E6 | WDR7 | S1063 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y4H2 | IRS2 | S985 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y572 | RIPK3 | S410 | ochoa | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) | Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). {ECO:0000250|UniProtKB:Q9QZL0, ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:25316792, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:32298652, ECO:0000269|PubMed:32657447}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269|PubMed:33348174}. |
| P00519 | ABL1 | S559 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| Q86UE8 | TLK2 | S85 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9909396 | Circadian clock | 0.000003 | 5.505 |
| R-HSA-9707616 | Heme signaling | 0.000022 | 4.653 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000036 | 4.441 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000083 | 4.080 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.000207 | 3.683 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.000752 | 3.124 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.000648 | 3.189 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.000825 | 3.084 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.001254 | 2.902 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.001895 | 2.722 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.002177 | 2.662 |
| R-HSA-525793 | Myogenesis | 0.002177 | 2.662 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.002930 | 2.533 |
| R-HSA-1266738 | Developmental Biology | 0.002795 | 2.554 |
| R-HSA-212436 | Generic Transcription Pathway | 0.002742 | 2.562 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.003388 | 2.470 |
| R-HSA-74160 | Gene expression (Transcription) | 0.003265 | 2.486 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.003877 | 2.411 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.004516 | 2.345 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.004995 | 2.301 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.006426 | 2.192 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.006426 | 2.192 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.005744 | 2.241 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.006333 | 2.198 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.007856 | 2.105 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.008170 | 2.088 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.010178 | 1.992 |
| R-HSA-166520 | Signaling by NTRKs | 0.010507 | 1.979 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.011136 | 1.953 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.012214 | 1.913 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.012214 | 1.913 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.015127 | 1.820 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.018671 | 1.729 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.019583 | 1.708 |
| R-HSA-5619052 | Defective SLC9A9 causes autism 16 (AUTS16) | 0.023385 | 1.631 |
| R-HSA-4717374 | Defective DPM1 causes DPM1-CDG | 0.038672 | 1.413 |
| R-HSA-5579006 | Defective GSS causes GSS deficiency | 0.038672 | 1.413 |
| R-HSA-4719377 | Defective DPM2 causes DPM2-CDG | 0.038672 | 1.413 |
| R-HSA-4719360 | Defective DPM3 causes DPM3-CDG | 0.038672 | 1.413 |
| R-HSA-74713 | IRS activation | 0.053722 | 1.270 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.061159 | 1.214 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.068538 | 1.164 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.068538 | 1.164 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.075860 | 1.120 |
| R-HSA-112412 | SOS-mediated signalling | 0.075860 | 1.120 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.097484 | 1.011 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.104580 | 0.981 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.104580 | 0.981 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.104580 | 0.981 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.111620 | 0.952 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.118606 | 0.926 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.118606 | 0.926 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.118606 | 0.926 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.118606 | 0.926 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.118606 | 0.926 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.118606 | 0.926 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.125537 | 0.901 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.139237 | 0.856 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.139237 | 0.856 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.191941 | 0.717 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.191941 | 0.717 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.204609 | 0.689 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.229356 | 0.639 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.241442 | 0.617 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.241442 | 0.617 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.108588 | 0.964 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.150708 | 0.822 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.150708 | 0.822 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.027401 | 1.562 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.118606 | 0.926 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.090332 | 1.044 |
| R-HSA-198203 | PI3K/AKT activation | 0.097484 | 1.011 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.293542 | 0.532 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.265052 | 0.577 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.125537 | 0.901 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.104580 | 0.981 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.046344 | 1.334 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.059789 | 1.223 |
| R-HSA-72172 | mRNA Splicing | 0.032961 | 1.482 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.083125 | 1.080 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.046227 | 1.335 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.036862 | 1.433 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.126608 | 0.898 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.036685 | 1.436 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.132414 | 0.878 |
| R-HSA-9930044 | Nuclear RNA decay | 0.265052 | 0.577 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.088810 | 1.052 |
| R-HSA-8866376 | Reelin signalling pathway | 0.053722 | 1.270 |
| R-HSA-162699 | Synthesis of dolichyl-phosphate mannose | 0.061159 | 1.214 |
| R-HSA-4839744 | Signaling by APC mutants | 0.104580 | 0.981 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.111620 | 0.952 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.118606 | 0.926 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.139237 | 0.856 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.042064 | 1.376 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.025253 | 1.598 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.166002 | 0.780 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.172825 | 0.762 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.075860 | 1.120 |
| R-HSA-74749 | Signal attenuation | 0.097484 | 1.011 |
| R-HSA-9620244 | Long-term potentiation | 0.217080 | 0.663 |
| R-HSA-3295583 | TRP channels | 0.223242 | 0.651 |
| R-HSA-182971 | EGFR downregulation | 0.253340 | 0.596 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.097484 | 1.011 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.036685 | 1.436 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.025295 | 1.597 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.131880 | 0.880 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.121388 | 0.916 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.046227 | 1.335 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.075860 | 1.120 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.139237 | 0.856 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.172563 | 0.763 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.172563 | 0.763 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.070026 | 1.155 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.139237 | 0.856 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.043918 | 1.357 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.253340 | 0.596 |
| R-HSA-9733709 | Cardiogenesis | 0.038446 | 1.415 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.029969 | 1.523 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.129827 | 0.887 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.125537 | 0.901 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.229356 | 0.639 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.265052 | 0.577 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.128070 | 0.893 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.128070 | 0.893 |
| R-HSA-9664407 | Parasite infection | 0.128070 | 0.893 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.083125 | 1.080 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.090332 | 1.044 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.139237 | 0.856 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.139237 | 0.856 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.191941 | 0.717 |
| R-HSA-429947 | Deadenylation of mRNA | 0.210869 | 0.676 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.253340 | 0.596 |
| R-HSA-2028269 | Signaling by Hippo | 0.159389 | 0.798 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.118606 | 0.926 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.116223 | 0.935 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.045803 | 1.339 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.146007 | 0.836 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.098632 | 1.006 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.101096 | 0.995 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.265052 | 0.577 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.265052 | 0.577 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.166002 | 0.780 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.047997 | 1.319 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.135765 | 0.867 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.043918 | 1.357 |
| R-HSA-6793080 | rRNA modification in the mitochondrion | 0.125537 | 0.901 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.139237 | 0.856 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.179073 | 0.747 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.265052 | 0.577 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.046069 | 1.337 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.195996 | 0.708 |
| R-HSA-8953854 | Metabolism of RNA | 0.234719 | 0.629 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.191941 | 0.717 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.040239 | 1.395 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.132414 | 0.878 |
| R-HSA-198753 | ERK/MAPK targets | 0.185532 | 0.732 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.235423 | 0.628 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.204609 | 0.689 |
| R-HSA-112311 | Neurotransmitter clearance | 0.247414 | 0.607 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.185532 | 0.732 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.210869 | 0.676 |
| R-HSA-3214842 | HDMs demethylate histones | 0.217080 | 0.663 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.068313 | 1.165 |
| R-HSA-195721 | Signaling by WNT | 0.107883 | 0.967 |
| R-HSA-416700 | Other semaphorin interactions | 0.139237 | 0.856 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.191941 | 0.717 |
| R-HSA-2586552 | Signaling by Leptin | 0.097484 | 1.011 |
| R-HSA-9842663 | Signaling by LTK | 0.118606 | 0.926 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.125537 | 0.901 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.217080 | 0.663 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.217080 | 0.663 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.088756 | 1.052 |
| R-HSA-1989781 | PPARA activates gene expression | 0.157145 | 0.804 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.101096 | 0.995 |
| R-HSA-4839726 | Chromatin organization | 0.062681 | 1.203 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.279398 | 0.554 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.142018 | 0.848 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.253340 | 0.596 |
| R-HSA-381042 | PERK regulates gene expression | 0.282280 | 0.549 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.204609 | 0.689 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.160916 | 0.793 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.147845 | 0.830 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.129238 | 0.889 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.229946 | 0.638 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.026817 | 1.572 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.027602 | 1.559 |
| R-HSA-9758941 | Gastrulation | 0.146007 | 0.836 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.090332 | 1.044 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.047718 | 1.321 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.198300 | 0.703 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.126608 | 0.898 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.265052 | 0.577 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.265052 | 0.577 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.261923 | 0.582 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.241442 | 0.617 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.057710 | 1.239 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.237978 | 0.623 |
| R-HSA-9675108 | Nervous system development | 0.105089 | 0.978 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.204609 | 0.689 |
| R-HSA-162582 | Signal Transduction | 0.110295 | 0.957 |
| R-HSA-422475 | Axon guidance | 0.289247 | 0.539 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.057004 | 1.244 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.037999 | 1.420 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.214196 | 0.669 |
| R-HSA-8853659 | RET signaling | 0.287933 | 0.541 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.250277 | 0.602 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.250277 | 0.602 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.235746 | 0.628 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.204609 | 0.689 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.241442 | 0.617 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.044722 | 1.349 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.145274 | 0.838 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.293542 | 0.532 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.265052 | 0.577 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.230668 | 0.637 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.267748 | 0.572 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.293942 | 0.532 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.299107 | 0.524 |
| R-HSA-1566948 | Elastic fibre formation | 0.299107 | 0.524 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.302652 | 0.519 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.302652 | 0.519 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.302652 | 0.519 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.304628 | 0.516 |
| R-HSA-201556 | Signaling by ALK | 0.304628 | 0.516 |
| R-HSA-9646399 | Aggrephagy | 0.310107 | 0.508 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.310107 | 0.508 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.310107 | 0.508 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.310107 | 0.508 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.310107 | 0.508 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.310107 | 0.508 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.313699 | 0.503 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.315542 | 0.501 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.315542 | 0.501 |
| R-HSA-72312 | rRNA processing | 0.319896 | 0.495 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.319940 | 0.495 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.320935 | 0.494 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.320935 | 0.494 |
| R-HSA-9843745 | Adipogenesis | 0.322897 | 0.491 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.326286 | 0.486 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.326286 | 0.486 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.331595 | 0.479 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.336863 | 0.473 |
| R-HSA-69236 | G1 Phase | 0.336863 | 0.473 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.338048 | 0.471 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.340137 | 0.468 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.342089 | 0.466 |
| R-HSA-6807070 | PTEN Regulation | 0.348708 | 0.458 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.357432 | 0.447 |
| R-HSA-70263 | Gluconeogenesis | 0.357524 | 0.447 |
| R-HSA-425410 | Metal ion SLC transporters | 0.357524 | 0.447 |
| R-HSA-109704 | PI3K Cascade | 0.367614 | 0.435 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.374189 | 0.427 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.376997 | 0.424 |
| R-HSA-72187 | mRNA 3'-end processing | 0.377547 | 0.423 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.377547 | 0.423 |
| R-HSA-1221632 | Meiotic synapsis | 0.382455 | 0.417 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.392157 | 0.407 |
| R-HSA-177929 | Signaling by EGFR | 0.396951 | 0.401 |
| R-HSA-112399 | IRS-mediated signalling | 0.401707 | 0.396 |
| R-HSA-877300 | Interferon gamma signaling | 0.407524 | 0.390 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.410265 | 0.387 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.411108 | 0.386 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.415754 | 0.381 |
| R-HSA-156590 | Glutathione conjugation | 0.415754 | 0.381 |
| R-HSA-446728 | Cell junction organization | 0.418098 | 0.379 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.420363 | 0.376 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.420363 | 0.376 |
| R-HSA-450294 | MAP kinase activation | 0.420363 | 0.376 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.424382 | 0.372 |
| R-HSA-9658195 | Leishmania infection | 0.424382 | 0.372 |
| R-HSA-1268020 | Mitochondrial protein import | 0.424936 | 0.372 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.424936 | 0.372 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.429474 | 0.367 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.429474 | 0.367 |
| R-HSA-373755 | Semaphorin interactions | 0.429474 | 0.367 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.433975 | 0.363 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.433975 | 0.363 |
| R-HSA-2262752 | Cellular responses to stress | 0.435422 | 0.361 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.438442 | 0.358 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.439993 | 0.357 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.441024 | 0.356 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.442874 | 0.354 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.445311 | 0.351 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.447270 | 0.349 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.447960 | 0.349 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.447960 | 0.349 |
| R-HSA-5218859 | Regulated Necrosis | 0.451633 | 0.345 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.451633 | 0.345 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.455438 | 0.342 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.460256 | 0.337 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.460256 | 0.337 |
| R-HSA-448424 | Interleukin-17 signaling | 0.460256 | 0.337 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.464516 | 0.333 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.468744 | 0.329 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.472938 | 0.325 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.472938 | 0.325 |
| R-HSA-9679506 | SARS-CoV Infections | 0.477856 | 0.321 |
| R-HSA-380287 | Centrosome maturation | 0.481228 | 0.318 |
| R-HSA-5689603 | UCH proteinases | 0.485325 | 0.314 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.485325 | 0.314 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.486826 | 0.313 |
| R-HSA-4086400 | PCP/CE pathway | 0.493422 | 0.307 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.493422 | 0.307 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.493422 | 0.307 |
| R-HSA-1500931 | Cell-Cell communication | 0.495734 | 0.305 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.497423 | 0.303 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.501392 | 0.300 |
| R-HSA-6806834 | Signaling by MET | 0.501392 | 0.300 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.506856 | 0.295 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.509238 | 0.293 |
| R-HSA-8957322 | Metabolism of steroids | 0.511443 | 0.291 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.516681 | 0.287 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.516962 | 0.287 |
| R-HSA-1500620 | Meiosis | 0.520778 | 0.283 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.521546 | 0.283 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.523966 | 0.281 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.532049 | 0.274 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.535747 | 0.271 |
| R-HSA-9663891 | Selective autophagy | 0.535747 | 0.271 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.535747 | 0.271 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.543057 | 0.265 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.553808 | 0.257 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.555138 | 0.256 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.557335 | 0.254 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.560835 | 0.251 |
| R-HSA-418990 | Adherens junctions interactions | 0.561567 | 0.251 |
| R-HSA-8951664 | Neddylation | 0.568380 | 0.245 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.571171 | 0.243 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.571171 | 0.243 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.574562 | 0.241 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.574562 | 0.241 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.577927 | 0.238 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.577927 | 0.238 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.577927 | 0.238 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.577927 | 0.238 |
| R-HSA-3214847 | HATs acetylate histones | 0.581265 | 0.236 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.591123 | 0.228 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.591123 | 0.228 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.591123 | 0.228 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.597568 | 0.224 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.600752 | 0.221 |
| R-HSA-8939211 | ESR-mediated signaling | 0.603429 | 0.219 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.607045 | 0.217 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.613240 | 0.212 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.613240 | 0.212 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.613451 | 0.212 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.616301 | 0.210 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.628307 | 0.202 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.631250 | 0.200 |
| R-HSA-421270 | Cell-cell junction organization | 0.632317 | 0.199 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.634170 | 0.198 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.639940 | 0.194 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.642233 | 0.192 |
| R-HSA-373760 | L1CAM interactions | 0.642792 | 0.192 |
| R-HSA-70326 | Glucose metabolism | 0.645620 | 0.190 |
| R-HSA-5693538 | Homology Directed Repair | 0.648427 | 0.188 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.651212 | 0.186 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.651212 | 0.186 |
| R-HSA-3371556 | Cellular response to heat stress | 0.656716 | 0.183 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.659435 | 0.181 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.659435 | 0.181 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.662133 | 0.179 |
| R-HSA-194138 | Signaling by VEGF | 0.670101 | 0.174 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.681871 | 0.166 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.682969 | 0.166 |
| R-HSA-1474165 | Reproduction | 0.685482 | 0.164 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.687975 | 0.162 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.690449 | 0.161 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.702529 | 0.153 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.709551 | 0.149 |
| R-HSA-1632852 | Macroautophagy | 0.714141 | 0.146 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.718659 | 0.143 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.720891 | 0.142 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.727483 | 0.138 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.738128 | 0.132 |
| R-HSA-9609507 | Protein localization | 0.742270 | 0.129 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.742270 | 0.129 |
| R-HSA-9612973 | Autophagy | 0.748361 | 0.126 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.750359 | 0.125 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.752342 | 0.124 |
| R-HSA-449147 | Signaling by Interleukins | 0.753815 | 0.123 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.755585 | 0.122 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.756260 | 0.121 |
| R-HSA-5619102 | SLC transporter disorders | 0.769497 | 0.114 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.785472 | 0.105 |
| R-HSA-611105 | Respiratory electron transport | 0.790549 | 0.102 |
| R-HSA-3781865 | Diseases of glycosylation | 0.800349 | 0.097 |
| R-HSA-69275 | G2/M Transition | 0.803513 | 0.095 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.806627 | 0.093 |
| R-HSA-983712 | Ion channel transport | 0.808166 | 0.092 |
| R-HSA-5617833 | Cilium Assembly | 0.809693 | 0.092 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.812710 | 0.090 |
| R-HSA-68877 | Mitotic Prometaphase | 0.814201 | 0.089 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.830633 | 0.081 |
| R-HSA-913531 | Interferon Signaling | 0.830633 | 0.081 |
| R-HSA-5357801 | Programmed Cell Death | 0.832543 | 0.080 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.841663 | 0.075 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.844657 | 0.073 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.860700 | 0.065 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.862914 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.869323 | 0.061 |
| R-HSA-5668914 | Diseases of metabolism | 0.871244 | 0.060 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.872453 | 0.059 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.880377 | 0.055 |
| R-HSA-109582 | Hemostasis | 0.883634 | 0.054 |
| R-HSA-5688426 | Deubiquitination | 0.887812 | 0.052 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.898929 | 0.046 |
| R-HSA-112316 | Neuronal System | 0.900885 | 0.045 |
| R-HSA-199991 | Membrane Trafficking | 0.901643 | 0.045 |
| R-HSA-168256 | Immune System | 0.905980 | 0.043 |
| R-HSA-168249 | Innate Immune System | 0.915184 | 0.038 |
| R-HSA-1280218 | Adaptive Immune System | 0.928611 | 0.032 |
| R-HSA-1640170 | Cell Cycle | 0.930351 | 0.031 |
| R-HSA-1474244 | Extracellular matrix organization | 0.939120 | 0.027 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.943838 | 0.025 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.947349 | 0.023 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.948043 | 0.023 |
| R-HSA-73894 | DNA Repair | 0.951824 | 0.021 |
| R-HSA-9824446 | Viral Infection Pathways | 0.952716 | 0.021 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.953355 | 0.021 |
| R-HSA-68886 | M Phase | 0.959997 | 0.018 |
| R-HSA-597592 | Post-translational protein modification | 0.960719 | 0.017 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.961750 | 0.017 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.962504 | 0.017 |
| R-HSA-5663205 | Infectious disease | 0.966149 | 0.015 |
| R-HSA-1643685 | Disease | 0.973655 | 0.012 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.977867 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 0.978224 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 0.987223 | 0.006 |
| R-HSA-211859 | Biological oxidations | 0.987279 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.994156 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.998248 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999315 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.846 | 0.727 | 1 | 0.931 |
KIS |
0.839 | 0.628 | 1 | 0.895 |
CDK17 |
0.836 | 0.716 | 1 | 0.931 |
HIPK2 |
0.836 | 0.648 | 1 | 0.920 |
CDK7 |
0.836 | 0.678 | 1 | 0.912 |
CDK19 |
0.833 | 0.662 | 1 | 0.923 |
P38G |
0.831 | 0.713 | 1 | 0.935 |
JNK2 |
0.831 | 0.725 | 1 | 0.921 |
CDK16 |
0.829 | 0.681 | 1 | 0.925 |
CDK8 |
0.829 | 0.659 | 1 | 0.907 |
CDK13 |
0.828 | 0.675 | 1 | 0.918 |
DYRK2 |
0.827 | 0.629 | 1 | 0.879 |
CDK14 |
0.826 | 0.693 | 1 | 0.911 |
CDK12 |
0.826 | 0.680 | 1 | 0.923 |
DYRK4 |
0.824 | 0.638 | 1 | 0.932 |
P38B |
0.823 | 0.682 | 1 | 0.907 |
P38D |
0.822 | 0.697 | 1 | 0.943 |
CDK3 |
0.822 | 0.601 | 1 | 0.932 |
ERK1 |
0.822 | 0.670 | 1 | 0.919 |
HIPK1 |
0.822 | 0.596 | 1 | 0.875 |
CDK9 |
0.822 | 0.663 | 1 | 0.918 |
CDK1 |
0.821 | 0.643 | 1 | 0.914 |
CDK5 |
0.821 | 0.648 | 1 | 0.896 |
CDK10 |
0.820 | 0.627 | 1 | 0.921 |
CLK3 |
0.820 | 0.410 | 1 | 0.704 |
HIPK4 |
0.819 | 0.428 | 1 | 0.722 |
P38A |
0.818 | 0.663 | 1 | 0.881 |
NLK |
0.817 | 0.621 | 1 | 0.743 |
JNK3 |
0.817 | 0.690 | 1 | 0.913 |
DYRK1B |
0.814 | 0.602 | 1 | 0.908 |
SRPK1 |
0.813 | 0.292 | -3 | 0.674 |
CLK4 |
0.811 | 0.372 | -3 | 0.682 |
DYRK1A |
0.810 | 0.512 | 1 | 0.853 |
CLK1 |
0.810 | 0.383 | -3 | 0.661 |
ERK2 |
0.809 | 0.654 | 1 | 0.890 |
HIPK3 |
0.809 | 0.573 | 1 | 0.843 |
CLK2 |
0.809 | 0.375 | -3 | 0.681 |
ERK5 |
0.807 | 0.356 | 1 | 0.675 |
DYRK3 |
0.807 | 0.490 | 1 | 0.847 |
CDK4 |
0.801 | 0.641 | 1 | 0.925 |
SRPK2 |
0.801 | 0.230 | -3 | 0.607 |
ICK |
0.800 | 0.314 | -3 | 0.745 |
JNK1 |
0.799 | 0.618 | 1 | 0.919 |
NDR2 |
0.799 | 0.063 | -3 | 0.760 |
CDK6 |
0.798 | 0.615 | 1 | 0.922 |
MTOR |
0.798 | 0.177 | 1 | 0.554 |
CDK2 |
0.798 | 0.489 | 1 | 0.843 |
COT |
0.797 | -0.042 | 2 | 0.804 |
CDKL5 |
0.797 | 0.149 | -3 | 0.709 |
PRKD1 |
0.796 | 0.098 | -3 | 0.738 |
MAK |
0.794 | 0.423 | -2 | 0.726 |
PRKD2 |
0.794 | 0.092 | -3 | 0.700 |
CDC7 |
0.793 | -0.037 | 1 | 0.422 |
AURC |
0.792 | 0.121 | -2 | 0.767 |
PIM3 |
0.791 | 0.019 | -3 | 0.758 |
CDKL1 |
0.791 | 0.120 | -3 | 0.715 |
RSK2 |
0.790 | 0.050 | -3 | 0.693 |
PRP4 |
0.789 | 0.419 | -3 | 0.714 |
NDR1 |
0.788 | 0.021 | -3 | 0.751 |
MOS |
0.787 | -0.001 | 1 | 0.479 |
P90RSK |
0.787 | 0.039 | -3 | 0.699 |
SKMLCK |
0.787 | 0.040 | -2 | 0.903 |
LATS2 |
0.787 | 0.030 | -5 | 0.793 |
PRPK |
0.786 | -0.067 | -1 | 0.753 |
PIM1 |
0.786 | 0.058 | -3 | 0.713 |
RSK3 |
0.786 | 0.042 | -3 | 0.690 |
CAMK1B |
0.785 | 0.013 | -3 | 0.753 |
SRPK3 |
0.784 | 0.183 | -3 | 0.641 |
MST4 |
0.784 | 0.020 | 2 | 0.843 |
MOK |
0.784 | 0.391 | 1 | 0.794 |
PDHK4 |
0.783 | -0.106 | 1 | 0.471 |
ATR |
0.782 | -0.018 | 1 | 0.444 |
CAMLCK |
0.782 | 0.068 | -2 | 0.896 |
MAPKAPK2 |
0.782 | 0.030 | -3 | 0.678 |
PKN3 |
0.782 | -0.011 | -3 | 0.735 |
MAPKAPK3 |
0.782 | 0.013 | -3 | 0.698 |
PKCD |
0.781 | 0.031 | 2 | 0.738 |
PKACG |
0.781 | 0.039 | -2 | 0.815 |
TBK1 |
0.781 | -0.131 | 1 | 0.352 |
GCN2 |
0.780 | -0.138 | 2 | 0.732 |
NIK |
0.780 | -0.006 | -3 | 0.770 |
WNK1 |
0.779 | -0.041 | -2 | 0.902 |
CAMK2D |
0.779 | -0.019 | -3 | 0.729 |
PKACB |
0.779 | 0.090 | -2 | 0.778 |
ULK2 |
0.779 | -0.137 | 2 | 0.724 |
MNK2 |
0.778 | 0.049 | -2 | 0.871 |
RAF1 |
0.778 | -0.164 | 1 | 0.405 |
PDHK1 |
0.778 | -0.103 | 1 | 0.445 |
RIPK3 |
0.777 | -0.063 | 3 | 0.771 |
BMPR2 |
0.777 | -0.115 | -2 | 0.866 |
CHAK2 |
0.777 | -0.024 | -1 | 0.747 |
TGFBR2 |
0.777 | -0.032 | -2 | 0.778 |
P70S6KB |
0.777 | 0.025 | -3 | 0.704 |
IKKE |
0.776 | -0.146 | 1 | 0.345 |
DAPK2 |
0.776 | 0.022 | -3 | 0.754 |
PKN2 |
0.776 | -0.027 | -3 | 0.736 |
AURB |
0.776 | 0.083 | -2 | 0.763 |
PRKD3 |
0.776 | 0.054 | -3 | 0.652 |
IKKB |
0.776 | -0.150 | -2 | 0.710 |
NUAK2 |
0.775 | -0.008 | -3 | 0.749 |
LATS1 |
0.775 | 0.053 | -3 | 0.769 |
NEK6 |
0.775 | -0.048 | -2 | 0.839 |
CAMK2G |
0.775 | -0.100 | 2 | 0.730 |
PAK1 |
0.775 | 0.030 | -2 | 0.849 |
DSTYK |
0.774 | -0.121 | 2 | 0.816 |
ERK7 |
0.774 | 0.224 | 2 | 0.524 |
PAK6 |
0.774 | 0.062 | -2 | 0.794 |
PRKX |
0.773 | 0.080 | -3 | 0.629 |
PAK3 |
0.773 | 0.012 | -2 | 0.850 |
PKG2 |
0.772 | 0.065 | -2 | 0.772 |
AMPKA1 |
0.771 | -0.060 | -3 | 0.759 |
PHKG1 |
0.771 | -0.022 | -3 | 0.729 |
PKCB |
0.771 | 0.008 | 2 | 0.689 |
NEK7 |
0.771 | -0.128 | -3 | 0.739 |
NEK9 |
0.771 | -0.076 | 2 | 0.781 |
PKCA |
0.770 | 0.026 | 2 | 0.689 |
MLK2 |
0.770 | -0.051 | 2 | 0.766 |
RSK4 |
0.770 | 0.036 | -3 | 0.681 |
AKT2 |
0.770 | 0.069 | -3 | 0.615 |
MSK2 |
0.770 | 0.007 | -3 | 0.663 |
MSK1 |
0.770 | 0.041 | -3 | 0.672 |
MARK4 |
0.770 | -0.079 | 4 | 0.672 |
MNK1 |
0.769 | 0.019 | -2 | 0.867 |
SMG1 |
0.769 | 0.022 | 1 | 0.416 |
NIM1 |
0.769 | -0.064 | 3 | 0.792 |
CAMK2B |
0.769 | -0.023 | 2 | 0.706 |
GSK3A |
0.769 | 0.165 | 4 | 0.446 |
AMPKA2 |
0.769 | -0.043 | -3 | 0.736 |
BCKDK |
0.769 | -0.128 | -1 | 0.671 |
TSSK1 |
0.768 | -0.020 | -3 | 0.775 |
MELK |
0.768 | -0.033 | -3 | 0.711 |
CAMK2A |
0.768 | -0.011 | 2 | 0.712 |
MASTL |
0.768 | -0.155 | -2 | 0.803 |
ULK1 |
0.768 | -0.157 | -3 | 0.716 |
IKKA |
0.767 | -0.072 | -2 | 0.683 |
HUNK |
0.767 | -0.154 | 2 | 0.738 |
PKCG |
0.767 | -0.011 | 2 | 0.694 |
SGK3 |
0.767 | 0.040 | -3 | 0.684 |
IRE1 |
0.767 | -0.089 | 1 | 0.414 |
MLK1 |
0.767 | -0.141 | 2 | 0.766 |
PKCZ |
0.766 | -0.015 | 2 | 0.726 |
GRK5 |
0.766 | -0.166 | -3 | 0.732 |
BMPR1B |
0.766 | -0.005 | 1 | 0.384 |
VRK2 |
0.765 | 0.100 | 1 | 0.521 |
AURA |
0.765 | 0.064 | -2 | 0.736 |
WNK3 |
0.765 | -0.183 | 1 | 0.405 |
CAMK4 |
0.765 | -0.070 | -3 | 0.717 |
PKACA |
0.765 | 0.072 | -2 | 0.742 |
MYLK4 |
0.765 | 0.029 | -2 | 0.847 |
PKR |
0.765 | -0.016 | 1 | 0.441 |
PIM2 |
0.765 | 0.041 | -3 | 0.663 |
TGFBR1 |
0.764 | -0.004 | -2 | 0.786 |
RIPK1 |
0.764 | -0.139 | 1 | 0.408 |
FAM20C |
0.764 | 0.004 | 2 | 0.590 |
ALK4 |
0.764 | -0.030 | -2 | 0.813 |
GRK1 |
0.764 | -0.063 | -2 | 0.723 |
PAK2 |
0.763 | -0.003 | -2 | 0.833 |
MLK3 |
0.762 | -0.064 | 2 | 0.705 |
DCAMKL1 |
0.762 | -0.009 | -3 | 0.708 |
MAPKAPK5 |
0.762 | -0.038 | -3 | 0.631 |
DNAPK |
0.762 | -0.030 | 1 | 0.368 |
TSSK2 |
0.761 | -0.077 | -5 | 0.808 |
NUAK1 |
0.761 | -0.046 | -3 | 0.704 |
DLK |
0.761 | -0.196 | 1 | 0.419 |
ANKRD3 |
0.761 | -0.163 | 1 | 0.439 |
NEK2 |
0.760 | -0.074 | 2 | 0.755 |
ATM |
0.760 | -0.070 | 1 | 0.383 |
GRK6 |
0.760 | -0.144 | 1 | 0.400 |
IRE2 |
0.760 | -0.090 | 2 | 0.698 |
CHK1 |
0.759 | -0.018 | -3 | 0.768 |
PKCH |
0.759 | -0.041 | 2 | 0.671 |
QSK |
0.759 | -0.052 | 4 | 0.644 |
PINK1 |
0.759 | 0.114 | 1 | 0.603 |
SIK |
0.758 | -0.050 | -3 | 0.665 |
MPSK1 |
0.758 | 0.048 | 1 | 0.495 |
BUB1 |
0.758 | 0.128 | -5 | 0.803 |
PAK5 |
0.757 | 0.043 | -2 | 0.737 |
GSK3B |
0.757 | 0.044 | 4 | 0.438 |
AKT1 |
0.757 | 0.047 | -3 | 0.634 |
YSK4 |
0.757 | -0.116 | 1 | 0.378 |
QIK |
0.756 | -0.110 | -3 | 0.712 |
PKCT |
0.756 | -0.009 | 2 | 0.681 |
PAK4 |
0.756 | 0.044 | -2 | 0.749 |
MEK1 |
0.755 | -0.128 | 2 | 0.763 |
CAMK1G |
0.755 | -0.043 | -3 | 0.660 |
ALK2 |
0.755 | -0.035 | -2 | 0.788 |
TLK2 |
0.754 | -0.078 | 1 | 0.371 |
CHAK1 |
0.753 | -0.139 | 2 | 0.733 |
GRK7 |
0.753 | -0.046 | 1 | 0.405 |
ACVR2A |
0.753 | -0.063 | -2 | 0.764 |
PLK1 |
0.753 | -0.146 | -2 | 0.771 |
DCAMKL2 |
0.753 | -0.038 | -3 | 0.718 |
GRK4 |
0.753 | -0.184 | -2 | 0.771 |
MST3 |
0.753 | -0.023 | 2 | 0.798 |
PLK4 |
0.752 | -0.095 | 2 | 0.561 |
P70S6K |
0.752 | -0.005 | -3 | 0.622 |
MLK4 |
0.752 | -0.111 | 2 | 0.683 |
TTBK2 |
0.752 | -0.196 | 2 | 0.648 |
WNK4 |
0.752 | -0.079 | -2 | 0.890 |
BRSK1 |
0.752 | -0.080 | -3 | 0.699 |
ACVR2B |
0.752 | -0.065 | -2 | 0.766 |
PKCI |
0.752 | -0.004 | 2 | 0.705 |
BRSK2 |
0.752 | -0.107 | -3 | 0.708 |
DRAK1 |
0.751 | -0.116 | 1 | 0.370 |
SMMLCK |
0.750 | 0.009 | -3 | 0.710 |
AKT3 |
0.750 | 0.055 | -3 | 0.575 |
SGK1 |
0.750 | 0.065 | -3 | 0.560 |
BMPR1A |
0.750 | -0.015 | 1 | 0.369 |
PKCE |
0.750 | 0.016 | 2 | 0.687 |
NEK5 |
0.750 | -0.062 | 1 | 0.416 |
MARK3 |
0.749 | -0.080 | 4 | 0.597 |
IRAK4 |
0.749 | -0.105 | 1 | 0.398 |
SBK |
0.749 | 0.110 | -3 | 0.520 |
PHKG2 |
0.748 | -0.072 | -3 | 0.689 |
PASK |
0.748 | -0.036 | -3 | 0.765 |
PERK |
0.748 | -0.111 | -2 | 0.802 |
PLK3 |
0.748 | -0.106 | 2 | 0.682 |
MARK2 |
0.747 | -0.092 | 4 | 0.563 |
CAMK1D |
0.747 | -0.015 | -3 | 0.608 |
MEKK1 |
0.746 | -0.129 | 1 | 0.415 |
MEK5 |
0.746 | -0.158 | 2 | 0.758 |
SNRK |
0.745 | -0.163 | 2 | 0.602 |
ROCK2 |
0.745 | 0.058 | -3 | 0.707 |
MRCKB |
0.744 | 0.053 | -3 | 0.649 |
HRI |
0.744 | -0.159 | -2 | 0.832 |
DAPK3 |
0.744 | 0.016 | -3 | 0.708 |
GAK |
0.744 | -0.005 | 1 | 0.501 |
ZAK |
0.744 | -0.151 | 1 | 0.389 |
PKN1 |
0.744 | -0.013 | -3 | 0.632 |
TAO3 |
0.744 | -0.059 | 1 | 0.428 |
LKB1 |
0.743 | -0.012 | -3 | 0.726 |
MRCKA |
0.742 | 0.037 | -3 | 0.668 |
MEKK2 |
0.742 | -0.127 | 2 | 0.739 |
BRAF |
0.742 | -0.131 | -4 | 0.863 |
MARK1 |
0.741 | -0.114 | 4 | 0.619 |
GRK2 |
0.741 | -0.108 | -2 | 0.663 |
CHK2 |
0.740 | 0.004 | -3 | 0.568 |
CK1E |
0.740 | -0.066 | -3 | 0.467 |
CAMK1A |
0.740 | 0.007 | -3 | 0.589 |
SSTK |
0.739 | -0.083 | 4 | 0.631 |
PBK |
0.739 | 0.021 | 1 | 0.475 |
LOK |
0.739 | -0.016 | -2 | 0.791 |
DAPK1 |
0.738 | 0.011 | -3 | 0.688 |
PKG1 |
0.738 | 0.038 | -2 | 0.712 |
PDK1 |
0.737 | -0.061 | 1 | 0.434 |
TAO2 |
0.737 | -0.074 | 2 | 0.788 |
MEKK3 |
0.737 | -0.208 | 1 | 0.413 |
NEK4 |
0.737 | -0.091 | 1 | 0.387 |
NEK11 |
0.737 | -0.142 | 1 | 0.411 |
MEKK6 |
0.736 | -0.068 | 1 | 0.405 |
DMPK1 |
0.736 | 0.067 | -3 | 0.674 |
CRIK |
0.736 | 0.052 | -3 | 0.643 |
CK1G1 |
0.736 | -0.080 | -3 | 0.451 |
HGK |
0.735 | -0.058 | 3 | 0.834 |
CK1D |
0.735 | -0.042 | -3 | 0.411 |
GCK |
0.735 | -0.071 | 1 | 0.400 |
NEK8 |
0.735 | -0.152 | 2 | 0.758 |
TNIK |
0.734 | -0.035 | 3 | 0.837 |
NEK1 |
0.734 | -0.064 | 1 | 0.393 |
HPK1 |
0.734 | -0.052 | 1 | 0.392 |
MAP3K15 |
0.733 | -0.088 | 1 | 0.396 |
CK1A2 |
0.733 | -0.055 | -3 | 0.413 |
CAMKK2 |
0.732 | -0.127 | -2 | 0.744 |
MINK |
0.731 | -0.088 | 1 | 0.383 |
TLK1 |
0.731 | -0.177 | -2 | 0.793 |
NEK3 |
0.731 | -0.017 | 1 | 0.403 |
LRRK2 |
0.731 | -0.067 | 2 | 0.780 |
KHS1 |
0.730 | -0.035 | 1 | 0.386 |
VRK1 |
0.730 | -0.094 | 2 | 0.775 |
IRAK1 |
0.729 | -0.225 | -1 | 0.687 |
MST2 |
0.729 | -0.110 | 1 | 0.392 |
ROCK1 |
0.729 | 0.034 | -3 | 0.669 |
CAMKK1 |
0.729 | -0.185 | -2 | 0.736 |
KHS2 |
0.729 | -0.024 | 1 | 0.398 |
BIKE |
0.728 | 0.030 | 1 | 0.474 |
CK2A2 |
0.728 | -0.078 | 1 | 0.364 |
TTBK1 |
0.728 | -0.177 | 2 | 0.573 |
PDHK3_TYR |
0.727 | 0.137 | 4 | 0.774 |
HASPIN |
0.727 | -0.002 | -1 | 0.626 |
YSK1 |
0.726 | -0.076 | 2 | 0.767 |
GRK3 |
0.726 | -0.108 | -2 | 0.614 |
EEF2K |
0.726 | -0.099 | 3 | 0.778 |
SLK |
0.725 | -0.076 | -2 | 0.709 |
PLK2 |
0.725 | -0.036 | -3 | 0.793 |
LIMK2_TYR |
0.725 | 0.183 | -3 | 0.783 |
STK33 |
0.725 | -0.131 | 2 | 0.563 |
AAK1 |
0.724 | 0.070 | 1 | 0.454 |
TAK1 |
0.722 | -0.160 | 1 | 0.377 |
MEK2 |
0.722 | -0.149 | 2 | 0.739 |
PKMYT1_TYR |
0.721 | 0.131 | 3 | 0.854 |
RIPK2 |
0.720 | -0.194 | 1 | 0.366 |
CK2A1 |
0.720 | -0.085 | 1 | 0.351 |
MST1 |
0.720 | -0.154 | 1 | 0.383 |
TESK1_TYR |
0.720 | 0.040 | 3 | 0.872 |
PDHK4_TYR |
0.717 | 0.029 | 2 | 0.805 |
MAP2K4_TYR |
0.717 | 0.037 | -1 | 0.761 |
MYO3B |
0.716 | -0.034 | 2 | 0.779 |
TTK |
0.715 | -0.053 | -2 | 0.790 |
OSR1 |
0.714 | -0.068 | 2 | 0.748 |
MAP2K6_TYR |
0.713 | -0.006 | -1 | 0.752 |
MAP2K7_TYR |
0.713 | -0.075 | 2 | 0.786 |
RET |
0.710 | -0.048 | 1 | 0.419 |
BMPR2_TYR |
0.710 | -0.019 | -1 | 0.743 |
TAO1 |
0.709 | -0.095 | 1 | 0.377 |
TNK2 |
0.709 | 0.025 | 3 | 0.797 |
ASK1 |
0.708 | -0.139 | 1 | 0.390 |
PDHK1_TYR |
0.707 | -0.077 | -1 | 0.757 |
PINK1_TYR |
0.707 | -0.163 | 1 | 0.470 |
MST1R |
0.706 | -0.031 | 3 | 0.835 |
LIMK1_TYR |
0.706 | -0.040 | 2 | 0.789 |
MYO3A |
0.706 | -0.085 | 1 | 0.395 |
TYRO3 |
0.706 | -0.042 | 3 | 0.807 |
YES1 |
0.705 | -0.015 | -1 | 0.776 |
EPHB4 |
0.705 | -0.041 | -1 | 0.717 |
ABL2 |
0.705 | -0.016 | -1 | 0.725 |
TXK |
0.705 | 0.014 | 1 | 0.411 |
JAK2 |
0.704 | -0.061 | 1 | 0.417 |
ABL1 |
0.703 | -0.010 | -1 | 0.729 |
YANK3 |
0.703 | -0.078 | 2 | 0.375 |
CSF1R |
0.702 | -0.040 | 3 | 0.814 |
NEK10_TYR |
0.702 | -0.041 | 1 | 0.353 |
TYK2 |
0.702 | -0.140 | 1 | 0.402 |
EPHA6 |
0.702 | -0.067 | -1 | 0.736 |
LCK |
0.701 | 0.000 | -1 | 0.766 |
TNK1 |
0.701 | -0.030 | 3 | 0.795 |
ROS1 |
0.700 | -0.088 | 3 | 0.782 |
AXL |
0.700 | -0.024 | 3 | 0.812 |
FGR |
0.699 | -0.092 | 1 | 0.432 |
JAK1 |
0.699 | -0.029 | 1 | 0.379 |
HCK |
0.699 | -0.044 | -1 | 0.770 |
BLK |
0.698 | 0.007 | -1 | 0.761 |
MERTK |
0.698 | -0.009 | 3 | 0.811 |
DDR1 |
0.697 | -0.144 | 4 | 0.663 |
TNNI3K_TYR |
0.697 | -0.020 | 1 | 0.451 |
FGFR2 |
0.697 | -0.045 | 3 | 0.818 |
ALPHAK3 |
0.696 | -0.140 | -1 | 0.653 |
ITK |
0.695 | -0.061 | -1 | 0.747 |
FGFR1 |
0.694 | -0.027 | 3 | 0.790 |
JAK3 |
0.694 | -0.122 | 1 | 0.412 |
SRMS |
0.694 | -0.090 | 1 | 0.390 |
TEK |
0.693 | -0.004 | 3 | 0.757 |
CK1A |
0.693 | -0.086 | -3 | 0.334 |
KDR |
0.693 | -0.069 | 3 | 0.788 |
STLK3 |
0.693 | -0.155 | 1 | 0.363 |
FER |
0.692 | -0.149 | 1 | 0.420 |
PDGFRB |
0.692 | -0.148 | 3 | 0.819 |
EPHB1 |
0.692 | -0.105 | 1 | 0.390 |
EPHB3 |
0.692 | -0.086 | -1 | 0.707 |
EPHA4 |
0.690 | -0.088 | 2 | 0.693 |
KIT |
0.690 | -0.111 | 3 | 0.818 |
FYN |
0.690 | -0.032 | -1 | 0.741 |
BMX |
0.689 | -0.060 | -1 | 0.678 |
PTK2B |
0.689 | -0.031 | -1 | 0.731 |
EPHB2 |
0.689 | -0.088 | -1 | 0.696 |
EPHA1 |
0.689 | -0.043 | 3 | 0.806 |
INSRR |
0.688 | -0.146 | 3 | 0.761 |
TEC |
0.688 | -0.070 | -1 | 0.717 |
DDR2 |
0.688 | -0.046 | 3 | 0.755 |
FLT3 |
0.686 | -0.159 | 3 | 0.806 |
BTK |
0.686 | -0.121 | -1 | 0.747 |
PDGFRA |
0.686 | -0.163 | 3 | 0.814 |
MET |
0.686 | -0.098 | 3 | 0.821 |
EPHA7 |
0.684 | -0.073 | 2 | 0.690 |
LTK |
0.684 | -0.110 | 3 | 0.761 |
WEE1_TYR |
0.684 | -0.094 | -1 | 0.668 |
FGFR3 |
0.684 | -0.075 | 3 | 0.793 |
PTK6 |
0.683 | -0.144 | -1 | 0.680 |
LYN |
0.682 | -0.071 | 3 | 0.735 |
SRC |
0.682 | -0.054 | -1 | 0.743 |
FRK |
0.681 | -0.086 | -1 | 0.777 |
EPHA3 |
0.681 | -0.114 | 2 | 0.668 |
ALK |
0.681 | -0.139 | 3 | 0.732 |
NTRK1 |
0.680 | -0.170 | -1 | 0.681 |
ERBB2 |
0.679 | -0.148 | 1 | 0.380 |
FLT1 |
0.678 | -0.154 | -1 | 0.682 |
NTRK2 |
0.678 | -0.162 | 3 | 0.777 |
NTRK3 |
0.677 | -0.119 | -1 | 0.636 |
FLT4 |
0.676 | -0.155 | 3 | 0.772 |
EPHA5 |
0.675 | -0.101 | 2 | 0.668 |
CSK |
0.674 | -0.113 | 2 | 0.697 |
MATK |
0.674 | -0.109 | -1 | 0.625 |
EGFR |
0.674 | -0.098 | 1 | 0.328 |
EPHA8 |
0.674 | -0.086 | -1 | 0.687 |
INSR |
0.673 | -0.169 | 3 | 0.742 |
CK1G3 |
0.673 | -0.085 | -3 | 0.290 |
PTK2 |
0.672 | -0.057 | -1 | 0.661 |
FGFR4 |
0.671 | -0.093 | -1 | 0.643 |
MUSK |
0.668 | -0.129 | 1 | 0.323 |
YANK2 |
0.666 | -0.106 | 2 | 0.387 |
EPHA2 |
0.664 | -0.100 | -1 | 0.650 |
ERBB4 |
0.661 | -0.089 | 1 | 0.327 |
SYK |
0.661 | -0.104 | -1 | 0.636 |
IGF1R |
0.656 | -0.170 | 3 | 0.687 |
FES |
0.651 | -0.126 | -1 | 0.649 |
ZAP70 |
0.651 | -0.071 | -1 | 0.575 |
CK1G2 |
0.648 | -0.106 | -3 | 0.375 |