Motif 251 (n=150)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6ND36 | FAM83G | S124 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A6NI28 | ARHGAP42 | S587 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| H7BY64 | ZNF511-PRAP1 | S126 | ochoa | ZNF511-PRAP1 readthrough | None |
| O14492 | SH2B2 | S594 | ochoa | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}. |
| O14828 | SCAMP3 | S91 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O43150 | ASAP2 | S722 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. |
| O43439 | CBFA2T2 | S264 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O43561 | LAT | S91 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43639 | NCK2 | S270 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
| O60281 | ZNF292 | S1159 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60381 | HBP1 | S372 | psp | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}. |
| O60716 | CTNND1 | S169 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O94967 | WDR47 | S304 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| P09769 | FGR | S54 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0DP72 | VSIG10L2 | S88 | ochoa | V-set and immunoglobulin domain-containing protein 10-like 2 | None |
| P0DPH7 | TUBA3C | S277 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S277 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P18669 | PGAM1 | S134 | ochoa | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P21860 | ERBB3 | S1097 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P23526 | AHCY | S187 | ochoa | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P27448 | MARK3 | S543 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27707 | DCK | S63 | ochoa | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P31645 | SLC6A4 | S62 | ochoa | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P38398 | BRCA1 | S1596 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P38646 | HSPA9 | S376 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P39880 | CUX1 | S1378 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40855 | PEX19 | S66 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| P41161 | ETV5 | S94 | ochoa | ETS translocation variant 5 (Ets-related protein ERM) | Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}. |
| P41212 | ETV6 | S203 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P46109 | CRKL | S112 | ochoa | Crk-like protein | May mediate the transduction of intracellular signals. |
| P47710 | CSN1S1 | S31 | psp | Alpha-S1-casein [Cleaved into: Casoxin-D] | Important role in the capacity of milk to transport calcium phosphate.; FUNCTION: Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors. |
| P49023 | PXN | S140 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49848 | TAF6 | S602 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P50750 | CDK9 | S353 | ochoa|psp | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | Protein kinase involved in the regulation of transcription (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094, PubMed:29335245). Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:16427012, PubMed:20930849, PubMed:28426094, PubMed:30134174). This complex is inactive when in the 7SK snRNP complex form (PubMed:10574912, PubMed:10757782, PubMed:11145967, PubMed:11575923, PubMed:11809800, PubMed:11884399, PubMed:14701750, PubMed:16109376, PubMed:16109377, PubMed:20930849, PubMed:28426094). Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE (PubMed:10912001, PubMed:11112772, PubMed:12037670, PubMed:16427012, PubMed:20081228, PubMed:20980437, PubMed:21127351, PubMed:9857195). Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) (PubMed:17956865, PubMed:18362169). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis (PubMed:10393184, PubMed:11112772). P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export (PubMed:15564463, PubMed:19575011, PubMed:19844166). Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing (PubMed:15564463, PubMed:19575011, PubMed:19844166). The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro (PubMed:21127351). Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage (PubMed:20493174). In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 (PubMed:20493174). Promotes cardiac myocyte enlargement (PubMed:20081228). RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription (PubMed:21127351). AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect (PubMed:10912001, PubMed:11112772, PubMed:9857195). The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation (PubMed:12037670). Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity (PubMed:29335245). {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11145967, ECO:0000269|PubMed:11575923, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:11884399, ECO:0000269|PubMed:12037670, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15564463, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:17956865, ECO:0000269|PubMed:18362169, ECO:0000269|PubMed:19575011, ECO:0000269|PubMed:19844166, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:20930849, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:9857195}. |
| P51532 | SMARCA4 | S132 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51787 | KCNQ1 | S92 | ochoa | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P68363 | TUBA1B | S277 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S277 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q01196 | RUNX1 | S229 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q02086 | SP2 | S187 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02750 | MAP2K1 | S299 | ochoa | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q08AM6 | VAC14 | S491 | ochoa | Protein VAC14 homolog (Tax1-binding protein 2) | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}. |
| Q12904 | AIMP1 | S90 | ochoa | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:12237313, ECO:0000269|PubMed:19362550}. |
| Q12948 | FOXC1 | S248 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q12965 | MYO1E | S1009 | ochoa | Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) | Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408, ECO:0000269|PubMed:36316095}. |
| Q13422 | IKZF1 | S364 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13501 | SQSTM1 | S180 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13501 | SQSTM1 | S229 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q14671 | PUM1 | S75 | ochoa | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q14980 | NUMA1 | S1788 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15418 | RPS6KA1 | S684 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15424 | SAFB | S555 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15652 | JMJD1C | S1223 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15691 | MAPRE1 | S155 | ochoa|psp | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q16891 | IMMT | S103 | ochoa|psp | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q2KHR3 | QSER1 | S1211 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2LD37 | BLTP1 | S4607 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2M2I8 | AAK1 | S850 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q2M3C6 | TMEM266 | S471 | ochoa | Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1) | Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). {ECO:0000269|PubMed:25165868, ECO:0000269|PubMed:30810529}. |
| Q2NKX8 | ERCC6L | S872 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q2NKX8 | ERCC6L | S1188 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q5FWE3 | PRRT3 | S769 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5SNT2 | TMEM201 | S555 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5T481 | RBM20 | S1060 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5VST9 | OBSCN | S6961 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VUB5 | FAM171A1 | S356 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q66K74 | MAP1S | S766 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q674X7 | KAZN | S310 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Q69YZ2 | TMEM200B | S282 | ochoa | Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B) | None |
| Q6PEY2 | TUBA3E | S277 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PKG0 | LARP1 | S577 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6QNY0 | BLOC1S3 | S30 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| Q6ZRV2 | FAM83H | S759 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZSR9 | None | S258 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q71U36 | TUBA1A | S277 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7RTP6 | MICAL3 | S1365 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2W4 | ZC3HAV1 | S353 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3B3 | KANSL1 | S1045 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z7B0 | FILIP1 | S967 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86T24 | ZBTB33 | S232 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
| Q86UZ6 | ZBTB46 | S234 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86V48 | LUZP1 | S611 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86X10 | RALGAPB | S373 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86YV0 | RASAL3 | S857 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IV50 | LYSMD2 | S29 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IVW6 | ARID3B | S61 | ochoa | AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein) | Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269|PubMed:16951138, ECO:0000269|PubMed:17400556}. |
| Q8IWY9 | CDAN1 | S277 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
| Q8IX07 | ZFPM1 | S506 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY92 | SLX4 | S199 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N0Y7 | PGAM4 | S134 | ochoa | Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) | None |
| Q8N612 | FHIP1B | S855 | ochoa | FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q8NB15 | ZNF511 | S183 | ochoa | Zinc finger protein 511 | May be involved in transcriptional regulation. {ECO:0000305}. |
| Q8ND24 | RNF214 | S25 | ochoa | RING finger protein 214 | None |
| Q8TE68 | EPS8L1 | S237 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TEH3 | DENND1A | S538 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TEK3 | DOT1L | S1030 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WUH6 | TMEM263 | S23 | ochoa | Transmembrane protein 263 | May play a role in bone development. {ECO:0000269|PubMed:34238371}. |
| Q8WXX7 | AUTS2 | S951 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q8WYQ5 | DGCR8 | S383 | ochoa | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92619 | ARHGAP45 | S54 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92888 | ARHGEF1 | S776 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q96D71 | REPS1 | S143 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96GX5 | MASTL | S631 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96JM3 | CHAMP1 | S121 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96MF2 | STAC3 | S21 | ochoa | SH3 and cysteine-rich domain-containing protein 3 | Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). {ECO:0000250|UniProtKB:Q8BZ71, ECO:0000269|PubMed:23736855, ECO:0000269|PubMed:29078335}. |
| Q96PM9 | ZNF385A | S160 | ochoa | Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}. |
| Q96PN7 | TRERF1 | S676 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q99640 | PKMYT1 | S22 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99704 | DOK1 | S310 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q99798 | ACO2 | S559 | ochoa | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| Q9BQC3 | DPH2 | S431 | ochoa | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}. |
| Q9BQE3 | TUBA1C | S277 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BW04 | SARG | S469 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BXK5 | BCL2L13 | S353 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BY44 | EIF2A | S524 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9BYE7 | PCGF6 | S233 | ochoa | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}. |
| Q9C0B9 | ZCCHC2 | S764 | ochoa | Zinc finger CCHC domain-containing protein 2 | None |
| Q9GZV9 | FGF23 | S212 | psp | Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] | Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}. |
| Q9H0H5 | RACGAP1 | S206 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H1D0 | TRPV6 | S731 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
| Q9H4L5 | OSBPL3 | S303 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H4Z2 | ZNF335 | S986 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H9J4 | USP42 | S863 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9P246 | STIM2 | S700 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P265 | DIP2B | S83 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P265 | DIP2B | S146 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UGN4 | CD300A | S256 | ochoa | CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}. |
| Q9UHW9 | SLC12A6 | S96 | ochoa|psp | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
| Q9UKK3 | PARP4 | S1489 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UQ35 | SRRM2 | S2171 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2453 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2U8 | LEMD3 | S185 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3Q8 | TSC22D4 | S207 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y446 | PKP3 | S80 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4B5 | MTCL1 | S1789 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S518 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S592 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5K6 | CD2AP | S554 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y613 | FHOD1 | S510 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y6N7 | ROBO1 | S1081 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| P52907 | CAPZA1 | S119 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| O75914 | PAK3 | S239 | Sugiyama | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O95721 | SNAP29 | S204 | Sugiyama | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| Q13155 | AIMP2 | S48 | Sugiyama | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
| P12830 | CDH1 | S36 | SIGNOR | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}. |
| Q4VCS5 | AMOT | S852 | EPSD | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| P19544 | WT1 | S208 | SIGNOR | Wilms tumor protein (WT33) | Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:17716689, PubMed:25258363, PubMed:7862533). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). {ECO:0000269|PubMed:15520190, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17716689, ECO:0000269|PubMed:19123921, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:7862533}. |
| Q12851 | MAP4K2 | S475 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q8IVH8 | MAP4K3 | S549 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q9H4A4 | RNPEP | S27 | Sugiyama | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 4.095352e-09 | 8.388 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 5.542801e-09 | 8.256 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 9.768307e-09 | 8.010 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.354329e-08 | 7.474 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 7.786266e-08 | 7.109 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.371852e-07 | 6.863 |
| R-HSA-437239 | Recycling pathway of L1 | 1.259489e-07 | 6.900 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.949671e-07 | 6.710 |
| R-HSA-190861 | Gap junction assembly | 2.720266e-07 | 6.565 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.484975e-07 | 6.458 |
| R-HSA-983189 | Kinesins | 6.150609e-07 | 6.211 |
| R-HSA-9646399 | Aggrephagy | 6.724548e-07 | 6.172 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.536497e-07 | 6.069 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.623975e-07 | 6.118 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.022395e-07 | 6.045 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.850571e-07 | 6.053 |
| R-HSA-190828 | Gap junction trafficking | 1.307843e-06 | 5.883 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.398179e-06 | 5.854 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.888025e-06 | 5.724 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.230086e-06 | 5.652 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.383521e-06 | 5.623 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.076202e-06 | 5.390 |
| R-HSA-9833482 | PKR-mediated signaling | 4.076202e-06 | 5.390 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.075628e-06 | 5.295 |
| R-HSA-438064 | Post NMDA receptor activation events | 7.635043e-06 | 5.117 |
| R-HSA-9663891 | Selective autophagy | 8.224274e-06 | 5.085 |
| R-HSA-373760 | L1CAM interactions | 8.958212e-06 | 5.048 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.205105e-05 | 4.919 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.352145e-05 | 4.869 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.388083e-05 | 4.858 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.655119e-05 | 4.781 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.655119e-05 | 4.781 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.797751e-05 | 4.745 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.942969e-05 | 4.712 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.464635e-05 | 4.608 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.432768e-05 | 4.614 |
| R-HSA-5620924 | Intraflagellar transport | 2.725415e-05 | 4.565 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 3.147557e-05 | 4.502 |
| R-HSA-69275 | G2/M Transition | 5.538918e-05 | 4.257 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.999032e-05 | 4.222 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.584026e-05 | 4.182 |
| R-HSA-68877 | Mitotic Prometaphase | 7.294031e-05 | 4.137 |
| R-HSA-391251 | Protein folding | 9.566822e-05 | 4.019 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.007641e-04 | 3.997 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.183136e-04 | 3.927 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.773411e-04 | 3.751 |
| R-HSA-68882 | Mitotic Anaphase | 1.732589e-04 | 3.761 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.791884e-04 | 3.747 |
| R-HSA-1632852 | Macroautophagy | 2.420549e-04 | 3.616 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.225777e-04 | 3.491 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.237520e-04 | 3.373 |
| R-HSA-9612973 | Autophagy | 4.569695e-04 | 3.340 |
| R-HSA-428540 | Activation of RAC1 | 5.215144e-04 | 3.283 |
| R-HSA-9675108 | Nervous system development | 4.824509e-04 | 3.317 |
| R-HSA-199991 | Membrane Trafficking | 5.215667e-04 | 3.283 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.159991e-04 | 3.145 |
| R-HSA-1500931 | Cell-Cell communication | 7.230043e-04 | 3.141 |
| R-HSA-422475 | Axon guidance | 7.349005e-04 | 3.134 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 8.029258e-04 | 3.095 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 8.029258e-04 | 3.095 |
| R-HSA-68886 | M Phase | 9.462890e-04 | 3.024 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.046228e-03 | 2.980 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.311067e-03 | 2.882 |
| R-HSA-5617833 | Cilium Assembly | 1.470750e-03 | 2.832 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.753007e-03 | 2.756 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.804788e-03 | 2.744 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.076512e-03 | 2.683 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.725717e-03 | 2.565 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.790330e-03 | 2.554 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.896302e-03 | 2.538 |
| R-HSA-418990 | Adherens junctions interactions | 3.253315e-03 | 2.488 |
| R-HSA-1640170 | Cell Cycle | 3.343154e-03 | 2.476 |
| R-HSA-446728 | Cell junction organization | 3.708120e-03 | 2.431 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.759313e-03 | 2.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.759313e-03 | 2.425 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.934682e-03 | 2.307 |
| R-HSA-1266738 | Developmental Biology | 4.974337e-03 | 2.303 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.395689e-03 | 2.268 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 5.795268e-03 | 2.237 |
| R-HSA-9609690 | HCMV Early Events | 6.850310e-03 | 2.164 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 6.910959e-03 | 2.160 |
| R-HSA-421270 | Cell-cell junction organization | 6.958116e-03 | 2.158 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 7.673739e-03 | 2.115 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 7.987397e-03 | 2.098 |
| R-HSA-9762292 | Regulation of CDH11 function | 7.987397e-03 | 2.098 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.967065e-03 | 2.047 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 9.202236e-03 | 2.036 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.112505e-02 | 1.954 |
| R-HSA-170968 | Frs2-mediated activation | 1.330165e-02 | 1.876 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.196042e-02 | 1.922 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.330165e-02 | 1.876 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.203525e-02 | 1.920 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.481429e-02 | 1.829 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.639735e-02 | 1.785 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.729812e-02 | 1.762 |
| R-HSA-169893 | Prolonged ERK activation events | 1.804926e-02 | 1.744 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.016407e-02 | 1.695 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.016407e-02 | 1.695 |
| R-HSA-9609646 | HCMV Infection | 2.137959e-02 | 1.670 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.155350e-02 | 1.666 |
| R-HSA-3928664 | Ephrin signaling | 2.340282e-02 | 1.631 |
| R-HSA-373753 | Nephrin family interactions | 2.728852e-02 | 1.564 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.728852e-02 | 1.564 |
| R-HSA-112316 | Neuronal System | 2.893221e-02 | 1.539 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 3.009404e-02 | 1.522 |
| R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 3.009404e-02 | 1.522 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.081354e-02 | 1.511 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.141409e-02 | 1.503 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.356333e-02 | 1.474 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 3.992398e-02 | 1.399 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.665330e-02 | 1.436 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.665330e-02 | 1.436 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.926637e-02 | 1.406 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 3.992398e-02 | 1.399 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.987521e-02 | 1.399 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.522753e-02 | 1.453 |
| R-HSA-8848021 | Signaling by PTK6 | 3.665330e-02 | 1.436 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.665330e-02 | 1.436 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.034068e-02 | 1.394 |
| R-HSA-109582 | Hemostasis | 3.639481e-02 | 1.439 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.060756e-02 | 1.391 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.270527e-02 | 1.370 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 4.379511e-02 | 1.359 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.404268e-02 | 1.356 |
| R-HSA-8949613 | Cristae formation | 4.512047e-02 | 1.346 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.512047e-02 | 1.346 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 5.928778e-02 | 1.227 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 5.928778e-02 | 1.227 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 6.882362e-02 | 1.162 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 6.882362e-02 | 1.162 |
| R-HSA-74713 | IRS activation | 6.882362e-02 | 1.162 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 6.882362e-02 | 1.162 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 6.882362e-02 | 1.162 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 7.826337e-02 | 1.106 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.826337e-02 | 1.106 |
| R-HSA-176417 | Phosphorylation of Emi1 | 7.826337e-02 | 1.106 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 7.826337e-02 | 1.106 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 8.760801e-02 | 1.057 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 8.760801e-02 | 1.057 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 9.685848e-02 | 1.014 |
| R-HSA-112412 | SOS-mediated signalling | 9.685848e-02 | 1.014 |
| R-HSA-72731 | Recycling of eIF2:GDP | 9.685848e-02 | 1.014 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.060157e-01 | 0.975 |
| R-HSA-444257 | RSK activation | 1.060157e-01 | 0.975 |
| R-HSA-8875656 | MET receptor recycling | 1.060157e-01 | 0.975 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.150807e-01 | 0.939 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.240543e-01 | 0.906 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.240543e-01 | 0.906 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.240543e-01 | 0.906 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.504360e-01 | 0.823 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.590532e-01 | 0.798 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 1.590532e-01 | 0.798 |
| R-HSA-9006335 | Signaling by Erythropoietin | 5.009766e-02 | 1.300 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 1.675835e-01 | 0.776 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.675835e-01 | 0.776 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.675835e-01 | 0.776 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.760279e-01 | 0.754 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.760279e-01 | 0.754 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.843870e-01 | 0.734 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.843870e-01 | 0.734 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 2.008534e-01 | 0.697 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.169892e-01 | 0.664 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.968035e-02 | 1.047 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 9.277929e-02 | 1.033 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 2.249353e-01 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.249353e-01 | 0.648 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.249353e-01 | 0.648 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.249353e-01 | 0.648 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.249353e-01 | 0.648 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.249353e-01 | 0.648 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.328012e-01 | 0.633 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.063278e-02 | 1.296 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 2.405878e-01 | 0.619 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.405878e-01 | 0.619 |
| R-HSA-380287 | Centrosome maturation | 5.369815e-02 | 1.270 |
| R-HSA-9766229 | Degradation of CDH1 | 1.152848e-01 | 0.938 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.424711e-01 | 0.846 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.817081e-01 | 0.741 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.079928e-01 | 0.967 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 8.125829e-02 | 1.090 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 9.685848e-02 | 1.014 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.169892e-01 | 0.664 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.249353e-01 | 0.648 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.054744e-01 | 0.977 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.054744e-01 | 0.977 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.054744e-01 | 0.977 |
| R-HSA-198203 | PI3K/AKT activation | 1.240543e-01 | 0.906 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 1.060157e-01 | 0.975 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.150807e-01 | 0.939 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.963537e-01 | 0.707 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.031038e-02 | 1.153 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.968035e-02 | 1.047 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.334074e-02 | 1.198 |
| R-HSA-167172 | Transcription of the HIV genome | 1.817081e-01 | 0.741 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.590532e-01 | 0.798 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 1.760279e-01 | 0.754 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 6.060537e-02 | 1.217 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.468236e-02 | 1.127 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.008534e-01 | 0.697 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.054744e-01 | 0.977 |
| R-HSA-202433 | Generation of second messenger molecules | 8.357886e-02 | 1.078 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 5.928778e-02 | 1.227 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 5.928778e-02 | 1.227 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.037316e-01 | 0.691 |
| R-HSA-5673000 | RAF activation | 6.611722e-02 | 1.180 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.780729e-01 | 0.749 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 2.089622e-01 | 0.680 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 8.968035e-02 | 1.047 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 5.928778e-02 | 1.227 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 8.760801e-02 | 1.057 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 1.329374e-01 | 0.876 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 1.417310e-01 | 0.849 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.417310e-01 | 0.849 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.504360e-01 | 0.823 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 1.504360e-01 | 0.823 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 1.590532e-01 | 0.798 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.590532e-01 | 0.798 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.009766e-02 | 1.300 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.760279e-01 | 0.754 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.089622e-01 | 0.680 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.565301e-01 | 0.805 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 9.090836e-02 | 1.041 |
| R-HSA-1268020 | Mitochondrial protein import | 1.600855e-01 | 0.796 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.917234e-01 | 0.717 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.760279e-01 | 0.754 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.037316e-01 | 0.691 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.504360e-01 | 0.823 |
| R-HSA-112399 | IRS-mediated signalling | 1.424711e-01 | 0.846 |
| R-HSA-74749 | Signal attenuation | 1.240543e-01 | 0.906 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.008534e-01 | 0.697 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 9.277929e-02 | 1.033 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.150807e-01 | 0.939 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 1.240543e-01 | 0.906 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 2.328012e-01 | 0.633 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.672403e-01 | 0.777 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.675835e-01 | 0.776 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.335100e-01 | 0.632 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 6.060537e-02 | 1.217 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.672403e-01 | 0.777 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 7.826337e-02 | 1.106 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 1.590532e-01 | 0.798 |
| R-HSA-8963901 | Chylomicron remodeling | 1.590532e-01 | 0.798 |
| R-HSA-5576893 | Phase 2 - plateau phase | 1.926619e-01 | 0.715 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.089622e-01 | 0.680 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.855540e-02 | 1.164 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.708385e-01 | 0.767 |
| R-HSA-9664873 | Pexophagy | 1.240543e-01 | 0.906 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 2.089622e-01 | 0.680 |
| R-HSA-6811438 | Intra-Golgi traffic | 8.968035e-02 | 1.047 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 5.009766e-02 | 1.300 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.675835e-01 | 0.776 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.008534e-01 | 0.697 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.169892e-01 | 0.664 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.287065e-01 | 0.890 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 6.060537e-02 | 1.217 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 8.661322e-02 | 1.062 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.060690e-02 | 1.217 |
| R-HSA-199920 | CREB phosphorylation | 8.760801e-02 | 1.057 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 9.685848e-02 | 1.014 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 9.685848e-02 | 1.014 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.060157e-01 | 0.975 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.417310e-01 | 0.849 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.504360e-01 | 0.823 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.504360e-01 | 0.823 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.169892e-01 | 0.664 |
| R-HSA-187687 | Signalling to ERKs | 6.893370e-02 | 1.162 |
| R-HSA-379724 | tRNA Aminoacylation | 1.529902e-01 | 0.815 |
| R-HSA-194138 | Signaling by VEGF | 5.588138e-02 | 1.253 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.859199e-02 | 1.006 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.826337e-02 | 1.106 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.826337e-02 | 1.106 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 7.826337e-02 | 1.106 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 1.590532e-01 | 0.798 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.675835e-01 | 0.776 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.760279e-01 | 0.754 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.185756e-01 | 0.660 |
| R-HSA-186763 | Downstream signal transduction | 5.526246e-02 | 1.258 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.926619e-01 | 0.715 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.030840e-01 | 0.987 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.063278e-02 | 1.296 |
| R-HSA-68875 | Mitotic Prophase | 1.574064e-01 | 0.803 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.556108e-01 | 0.808 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.150807e-01 | 0.939 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.590532e-01 | 0.798 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.675835e-01 | 0.776 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.089622e-01 | 0.680 |
| R-HSA-109704 | PI3K Cascade | 1.186053e-01 | 0.926 |
| R-HSA-1474165 | Reproduction | 1.872915e-01 | 0.727 |
| R-HSA-198753 | ERK/MAPK targets | 2.328012e-01 | 0.633 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.405878e-01 | 0.619 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.390005e-01 | 0.857 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.647335e-01 | 0.783 |
| R-HSA-2028269 | Signaling by Hippo | 2.008534e-01 | 0.697 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.945975e-02 | 1.226 |
| R-HSA-162582 | Signal Transduction | 1.014008e-01 | 0.994 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.675835e-01 | 0.776 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.843870e-01 | 0.734 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 8.968035e-02 | 1.047 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.590532e-01 | 0.798 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 1.926619e-01 | 0.715 |
| R-HSA-2586552 | Signaling by Leptin | 1.240543e-01 | 0.906 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.963537e-01 | 0.707 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.060157e-01 | 0.975 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.760279e-01 | 0.754 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.847455e-01 | 0.733 |
| R-HSA-186797 | Signaling by PDGF | 1.600855e-01 | 0.796 |
| R-HSA-450294 | MAP kinase activation | 1.565301e-01 | 0.805 |
| R-HSA-180292 | GAB1 signalosome | 2.089622e-01 | 0.680 |
| R-HSA-445144 | Signal transduction by L1 | 2.249353e-01 | 0.648 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 6.060537e-02 | 1.217 |
| R-HSA-448424 | Interleukin-17 signaling | 1.890110e-01 | 0.724 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 9.895567e-02 | 1.005 |
| R-HSA-8853659 | RET signaling | 7.178910e-02 | 1.144 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.405878e-01 | 0.619 |
| R-HSA-166520 | Signaling by NTRKs | 9.078036e-02 | 1.042 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.169892e-01 | 0.664 |
| R-HSA-2262752 | Cellular responses to stress | 6.535437e-02 | 1.185 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.089622e-01 | 0.680 |
| R-HSA-9945266 | Differentiation of T cells | 1.843870e-01 | 0.734 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.843870e-01 | 0.734 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.383691e-01 | 0.859 |
| R-HSA-9831926 | Nephron development | 2.089622e-01 | 0.680 |
| R-HSA-1280218 | Adaptive Immune System | 7.850842e-02 | 1.105 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.097054e-01 | 0.960 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.008534e-01 | 0.697 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.525800e-01 | 0.817 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.281320e-01 | 0.642 |
| R-HSA-9830369 | Kidney development | 1.780729e-01 | 0.749 |
| R-HSA-449147 | Signaling by Interleukins | 1.251026e-01 | 0.903 |
| R-HSA-913531 | Interferon Signaling | 5.588089e-02 | 1.253 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.467241e-02 | 1.072 |
| R-HSA-9758941 | Gastrulation | 2.425726e-01 | 0.615 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.479818e-01 | 0.606 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.482959e-01 | 0.605 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.482959e-01 | 0.605 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.482959e-01 | 0.605 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.485041e-01 | 0.605 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.485041e-01 | 0.605 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.522586e-01 | 0.598 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.522586e-01 | 0.598 |
| R-HSA-9609507 | Protein localization | 2.534097e-01 | 0.596 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 2.559261e-01 | 0.592 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.559261e-01 | 0.592 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.559261e-01 | 0.592 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.559261e-01 | 0.592 |
| R-HSA-73887 | Death Receptor Signaling | 2.561302e-01 | 0.592 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.634794e-01 | 0.579 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.634794e-01 | 0.579 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 2.634794e-01 | 0.579 |
| R-HSA-9865881 | Complex III assembly | 2.634794e-01 | 0.579 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.634794e-01 | 0.579 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.709565e-01 | 0.567 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.709565e-01 | 0.567 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.709565e-01 | 0.567 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.709565e-01 | 0.567 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.709565e-01 | 0.567 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.709565e-01 | 0.567 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.709565e-01 | 0.567 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.783581e-01 | 0.555 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.783581e-01 | 0.555 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.783581e-01 | 0.555 |
| R-HSA-3295583 | TRP channels | 2.783581e-01 | 0.555 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.785602e-01 | 0.555 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.785602e-01 | 0.555 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.835343e-01 | 0.547 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.856850e-01 | 0.544 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.856850e-01 | 0.544 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.856850e-01 | 0.544 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 2.856850e-01 | 0.544 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.860698e-01 | 0.544 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.929380e-01 | 0.533 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.929380e-01 | 0.533 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.929380e-01 | 0.533 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.929380e-01 | 0.533 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.929380e-01 | 0.533 |
| R-HSA-73614 | Pyrimidine salvage | 2.929380e-01 | 0.533 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.001178e-01 | 0.523 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 3.001178e-01 | 0.523 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.001178e-01 | 0.523 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 3.001178e-01 | 0.523 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.001178e-01 | 0.523 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.048043e-01 | 0.516 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.048043e-01 | 0.516 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.048043e-01 | 0.516 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.072251e-01 | 0.513 |
| R-HSA-2424491 | DAP12 signaling | 3.072251e-01 | 0.513 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.072251e-01 | 0.513 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.072251e-01 | 0.513 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.072251e-01 | 0.513 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.072251e-01 | 0.513 |
| R-HSA-112311 | Neurotransmitter clearance | 3.072251e-01 | 0.513 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.072251e-01 | 0.513 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.122754e-01 | 0.505 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.122754e-01 | 0.505 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.160048e-01 | 0.500 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.212253e-01 | 0.493 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.212253e-01 | 0.493 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.271650e-01 | 0.485 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.281195e-01 | 0.484 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.281195e-01 | 0.484 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.281195e-01 | 0.484 |
| R-HSA-168256 | Immune System | 3.292406e-01 | 0.482 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 3.308748e-01 | 0.480 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.345790e-01 | 0.476 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.349442e-01 | 0.475 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.349442e-01 | 0.475 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.349442e-01 | 0.475 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.416999e-01 | 0.466 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.416999e-01 | 0.466 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 3.416999e-01 | 0.466 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.416999e-01 | 0.466 |
| R-HSA-5205647 | Mitophagy | 3.416999e-01 | 0.466 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.456552e-01 | 0.461 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.456552e-01 | 0.461 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.483875e-01 | 0.458 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.483875e-01 | 0.458 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.483875e-01 | 0.458 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.483875e-01 | 0.458 |
| R-HSA-381042 | PERK regulates gene expression | 3.483875e-01 | 0.458 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.483875e-01 | 0.458 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.483875e-01 | 0.458 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.493344e-01 | 0.457 |
| R-HSA-202403 | TCR signaling | 3.530066e-01 | 0.452 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.530066e-01 | 0.452 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.530066e-01 | 0.452 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.550075e-01 | 0.450 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.550075e-01 | 0.450 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.550075e-01 | 0.450 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.615606e-01 | 0.442 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 3.615606e-01 | 0.442 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.615606e-01 | 0.442 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.639798e-01 | 0.439 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.676222e-01 | 0.435 |
| R-HSA-8875878 | MET promotes cell motility | 3.680476e-01 | 0.434 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.680476e-01 | 0.434 |
| R-HSA-74217 | Purine salvage | 3.680476e-01 | 0.434 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.680476e-01 | 0.434 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.744691e-01 | 0.427 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.748828e-01 | 0.426 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.808257e-01 | 0.419 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.808257e-01 | 0.419 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.808257e-01 | 0.419 |
| R-HSA-167169 | HIV Transcription Elongation | 3.808257e-01 | 0.419 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3.808257e-01 | 0.419 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.857099e-01 | 0.414 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.871181e-01 | 0.412 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.871181e-01 | 0.412 |
| R-HSA-5693538 | Homology Directed Repair | 3.893012e-01 | 0.410 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.928832e-01 | 0.406 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.928832e-01 | 0.406 |
| R-HSA-167161 | HIV Transcription Initiation | 3.933470e-01 | 0.405 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.933470e-01 | 0.405 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.933470e-01 | 0.405 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 3.933470e-01 | 0.405 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.933470e-01 | 0.405 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.995129e-01 | 0.398 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.000190e-01 | 0.398 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.035723e-01 | 0.394 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.035723e-01 | 0.394 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.056165e-01 | 0.392 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.056165e-01 | 0.392 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.056165e-01 | 0.392 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.106491e-01 | 0.387 |
| R-HSA-2172127 | DAP12 interactions | 4.116585e-01 | 0.385 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.116585e-01 | 0.385 |
| R-HSA-156581 | Methylation | 4.116585e-01 | 0.385 |
| R-HSA-373752 | Netrin-1 signaling | 4.116585e-01 | 0.385 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.176394e-01 | 0.379 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.176394e-01 | 0.379 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.176394e-01 | 0.379 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.176394e-01 | 0.379 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.235599e-01 | 0.373 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.235599e-01 | 0.373 |
| R-HSA-9675135 | Diseases of DNA repair | 4.235599e-01 | 0.373 |
| R-HSA-75153 | Apoptotic execution phase | 4.235599e-01 | 0.373 |
| R-HSA-69481 | G2/M Checkpoints | 4.246787e-01 | 0.372 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.352220e-01 | 0.361 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.352220e-01 | 0.361 |
| R-HSA-70263 | Gluconeogenesis | 4.352220e-01 | 0.361 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.352220e-01 | 0.361 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.409648e-01 | 0.356 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.409648e-01 | 0.356 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.466495e-01 | 0.350 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.466495e-01 | 0.350 |
| R-HSA-912446 | Meiotic recombination | 4.522768e-01 | 0.345 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.578473e-01 | 0.339 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.578473e-01 | 0.339 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4.578473e-01 | 0.339 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.623415e-01 | 0.335 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.633614e-01 | 0.334 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.633614e-01 | 0.334 |
| R-HSA-1221632 | Meiotic synapsis | 4.633614e-01 | 0.334 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.633614e-01 | 0.334 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.664312e-01 | 0.331 |
| R-HSA-72649 | Translation initiation complex formation | 4.688197e-01 | 0.329 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.688197e-01 | 0.329 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.742229e-01 | 0.324 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.794378e-01 | 0.319 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.795715e-01 | 0.319 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.795715e-01 | 0.319 |
| R-HSA-177929 | Signaling by EGFR | 4.795715e-01 | 0.319 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.795715e-01 | 0.319 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.848659e-01 | 0.314 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.848659e-01 | 0.314 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.855526e-01 | 0.314 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.888180e-01 | 0.311 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.901069e-01 | 0.310 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.901069e-01 | 0.310 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.952948e-01 | 0.305 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.004303e-01 | 0.301 |
| R-HSA-1227986 | Signaling by ERBB2 | 5.004303e-01 | 0.301 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.049503e-01 | 0.297 |
| R-HSA-8956321 | Nucleotide salvage | 5.055138e-01 | 0.296 |
| R-HSA-9824446 | Viral Infection Pathways | 5.057274e-01 | 0.296 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.105459e-01 | 0.292 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.105459e-01 | 0.292 |
| R-HSA-6799198 | Complex I biogenesis | 5.155271e-01 | 0.288 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.155271e-01 | 0.288 |
| R-HSA-373755 | Semaphorin interactions | 5.155271e-01 | 0.288 |
| R-HSA-4839726 | Chromatin organization | 5.175396e-01 | 0.286 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.176185e-01 | 0.286 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.176185e-01 | 0.286 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.207521e-01 | 0.283 |
| R-HSA-5688426 | Deubiquitination | 5.323622e-01 | 0.274 |
| R-HSA-162587 | HIV Life Cycle | 5.331508e-01 | 0.273 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.349532e-01 | 0.272 |
| R-HSA-196807 | Nicotinate metabolism | 5.349532e-01 | 0.272 |
| R-HSA-6798695 | Neutrophil degranulation | 5.384327e-01 | 0.269 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.396875e-01 | 0.268 |
| R-HSA-212436 | Generic Transcription Pathway | 5.404877e-01 | 0.267 |
| R-HSA-597592 | Post-translational protein modification | 5.487090e-01 | 0.261 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.536048e-01 | 0.257 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.536048e-01 | 0.257 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.536048e-01 | 0.257 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.581503e-01 | 0.253 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.581503e-01 | 0.253 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.626499e-01 | 0.250 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.635888e-01 | 0.249 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.671039e-01 | 0.246 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.671039e-01 | 0.246 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.715128e-01 | 0.243 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.801971e-01 | 0.236 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.833766e-01 | 0.234 |
| R-HSA-216083 | Integrin cell surface interactions | 5.844735e-01 | 0.233 |
| R-HSA-9659379 | Sensory processing of sound | 5.887065e-01 | 0.230 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 5.887065e-01 | 0.230 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.890191e-01 | 0.230 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.928967e-01 | 0.227 |
| R-HSA-6806834 | Signaling by MET | 5.928967e-01 | 0.227 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.970445e-01 | 0.224 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 5.970445e-01 | 0.224 |
| R-HSA-2559583 | Cellular Senescence | 6.028784e-01 | 0.220 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.092374e-01 | 0.215 |
| R-HSA-1500620 | Meiosis | 6.132197e-01 | 0.212 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.132197e-01 | 0.212 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.171616e-01 | 0.210 |
| R-HSA-1643685 | Disease | 6.179810e-01 | 0.209 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.210636e-01 | 0.207 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.210636e-01 | 0.207 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.242676e-01 | 0.205 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.321271e-01 | 0.199 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.399885e-01 | 0.194 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.399885e-01 | 0.194 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.472927e-01 | 0.189 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.472927e-01 | 0.189 |
| R-HSA-2029481 | FCGR activation | 6.508893e-01 | 0.186 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.508893e-01 | 0.186 |
| R-HSA-1296071 | Potassium Channels | 6.649151e-01 | 0.177 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.683332e-01 | 0.175 |
| R-HSA-6805567 | Keratinization | 6.716518e-01 | 0.173 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.717165e-01 | 0.173 |
| R-HSA-190236 | Signaling by FGFR | 6.717165e-01 | 0.173 |
| R-HSA-3214847 | HATs acetylate histones | 6.750656e-01 | 0.171 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.750656e-01 | 0.171 |
| R-HSA-70171 | Glycolysis | 6.783807e-01 | 0.169 |
| R-HSA-5663205 | Infectious disease | 6.788306e-01 | 0.168 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.815605e-01 | 0.166 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.849104e-01 | 0.164 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.849104e-01 | 0.164 |
| R-HSA-1483255 | PI Metabolism | 6.849104e-01 | 0.164 |
| R-HSA-397014 | Muscle contraction | 6.855676e-01 | 0.164 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.913084e-01 | 0.160 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.944587e-01 | 0.158 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.944587e-01 | 0.158 |
| R-HSA-418346 | Platelet homeostasis | 7.006640e-01 | 0.154 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.006640e-01 | 0.154 |
| R-HSA-69239 | Synthesis of DNA | 7.037194e-01 | 0.153 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.037194e-01 | 0.153 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.037194e-01 | 0.153 |
| R-HSA-211000 | Gene Silencing by RNA | 7.037194e-01 | 0.153 |
| R-HSA-8951664 | Neddylation | 7.055368e-01 | 0.151 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.067439e-01 | 0.151 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.067439e-01 | 0.151 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.067439e-01 | 0.151 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.097377e-01 | 0.149 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.127011e-01 | 0.147 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.155828e-01 | 0.145 |
| R-HSA-162906 | HIV Infection | 7.182586e-01 | 0.144 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.185380e-01 | 0.144 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.214121e-01 | 0.142 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.270730e-01 | 0.138 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.326196e-01 | 0.135 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.353508e-01 | 0.134 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.353508e-01 | 0.134 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.380542e-01 | 0.132 |
| R-HSA-70326 | Glucose metabolism | 7.380542e-01 | 0.132 |
| R-HSA-8939211 | ESR-mediated signaling | 7.384395e-01 | 0.132 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.433790e-01 | 0.129 |
| R-HSA-157118 | Signaling by NOTCH | 7.442501e-01 | 0.128 |
| R-HSA-3371556 | Cellular response to heat stress | 7.485962e-01 | 0.126 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.562249e-01 | 0.121 |
| R-HSA-392499 | Metabolism of proteins | 7.566998e-01 | 0.121 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.636235e-01 | 0.117 |
| R-HSA-114608 | Platelet degranulation | 7.660398e-01 | 0.116 |
| R-HSA-5576891 | Cardiac conduction | 7.777578e-01 | 0.109 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.800305e-01 | 0.108 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.822800e-01 | 0.107 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.852388e-01 | 0.105 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.916312e-01 | 0.101 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.973993e-01 | 0.098 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.994722e-01 | 0.097 |
| R-HSA-9664407 | Parasite infection | 7.994722e-01 | 0.097 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.994722e-01 | 0.097 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.009976e-01 | 0.096 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.027338e-01 | 0.095 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.055654e-01 | 0.094 |
| R-HSA-382551 | Transport of small molecules | 8.063348e-01 | 0.093 |
| R-HSA-74160 | Gene expression (Transcription) | 8.128360e-01 | 0.090 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.146565e-01 | 0.089 |
| R-HSA-2187338 | Visual phototransduction | 8.153145e-01 | 0.089 |
| R-HSA-69242 | S Phase | 8.172052e-01 | 0.088 |
| R-HSA-69306 | DNA Replication | 8.263740e-01 | 0.083 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.281521e-01 | 0.082 |
| R-HSA-9711097 | Cellular response to starvation | 8.350856e-01 | 0.078 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.384473e-01 | 0.077 |
| R-HSA-72766 | Translation | 8.394535e-01 | 0.076 |
| R-HSA-109581 | Apoptosis | 8.417409e-01 | 0.075 |
| R-HSA-5619102 | SLC transporter disorders | 8.496858e-01 | 0.071 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.572342e-01 | 0.067 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.601469e-01 | 0.065 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.601469e-01 | 0.065 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.615811e-01 | 0.065 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.662316e-01 | 0.062 |
| R-HSA-611105 | Respiratory electron transport | 8.671730e-01 | 0.062 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.738481e-01 | 0.059 |
| R-HSA-983712 | Ion channel transport | 8.814195e-01 | 0.055 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.844422e-01 | 0.053 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.873827e-01 | 0.052 |
| R-HSA-168249 | Innate Immune System | 8.887194e-01 | 0.051 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.917802e-01 | 0.050 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.973751e-01 | 0.047 |
| R-HSA-72172 | mRNA Splicing | 8.994731e-01 | 0.046 |
| R-HSA-5357801 | Programmed Cell Death | 9.005060e-01 | 0.046 |
| R-HSA-73894 | DNA Repair | 9.011692e-01 | 0.045 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.035956e-01 | 0.044 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.043920e-01 | 0.044 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.190912e-01 | 0.037 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.215577e-01 | 0.035 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.231639e-01 | 0.035 |
| R-HSA-15869 | Metabolism of nucleotides | 9.277890e-01 | 0.033 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.299967e-01 | 0.032 |
| R-HSA-9679506 | SARS-CoV Infections | 9.351658e-01 | 0.029 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.355613e-01 | 0.029 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.412975e-01 | 0.026 |
| R-HSA-416476 | G alpha (q) signalling events | 9.459686e-01 | 0.024 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.537537e-01 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 9.547036e-01 | 0.020 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.547036e-01 | 0.020 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.600261e-01 | 0.018 |
| R-HSA-1483257 | Phospholipid metabolism | 9.608318e-01 | 0.017 |
| R-HSA-195721 | Signaling by WNT | 9.620337e-01 | 0.017 |
| R-HSA-8957322 | Metabolism of steroids | 9.710275e-01 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 9.730635e-01 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 9.887135e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.902189e-01 | 0.004 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.927073e-01 | 0.003 |
| R-HSA-372790 | Signaling by GPCR | 9.944240e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.964332e-01 | 0.002 |
| R-HSA-8953854 | Metabolism of RNA | 9.998713e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999760e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999982e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.871 | 0.392 | 1 | 0.868 |
COT |
0.856 | 0.203 | 2 | 0.816 |
HIPK4 |
0.847 | 0.233 | 1 | 0.880 |
ERK5 |
0.843 | 0.297 | 1 | 0.911 |
PIM3 |
0.842 | 0.109 | -3 | 0.769 |
CLK2 |
0.842 | 0.272 | -3 | 0.666 |
NDR2 |
0.842 | 0.118 | -3 | 0.781 |
DYRK2 |
0.842 | 0.241 | 1 | 0.796 |
MTOR |
0.842 | 0.115 | 1 | 0.784 |
SRPK1 |
0.841 | 0.146 | -3 | 0.677 |
PRKD1 |
0.839 | 0.151 | -3 | 0.753 |
SKMLCK |
0.837 | 0.164 | -2 | 0.835 |
GRK1 |
0.835 | 0.162 | -2 | 0.706 |
PRPK |
0.835 | -0.019 | -1 | 0.856 |
IKKB |
0.834 | -0.012 | -2 | 0.709 |
KIS |
0.834 | 0.160 | 1 | 0.768 |
MOS |
0.834 | 0.058 | 1 | 0.810 |
DYRK4 |
0.834 | 0.261 | 1 | 0.715 |
CDKL1 |
0.833 | 0.091 | -3 | 0.721 |
CDKL5 |
0.833 | 0.152 | -3 | 0.715 |
CHAK2 |
0.833 | 0.104 | -1 | 0.876 |
CDC7 |
0.832 | -0.024 | 1 | 0.747 |
PRKD2 |
0.832 | 0.098 | -3 | 0.688 |
NLK |
0.832 | 0.093 | 1 | 0.850 |
RSK2 |
0.832 | 0.078 | -3 | 0.692 |
CAMK1B |
0.831 | 0.029 | -3 | 0.767 |
CDK1 |
0.831 | 0.215 | 1 | 0.703 |
ICK |
0.831 | 0.153 | -3 | 0.766 |
MAPKAPK2 |
0.830 | 0.087 | -3 | 0.652 |
PIM1 |
0.830 | 0.090 | -3 | 0.704 |
ATR |
0.830 | 0.036 | 1 | 0.817 |
HIPK2 |
0.830 | 0.210 | 1 | 0.719 |
CDK8 |
0.829 | 0.147 | 1 | 0.735 |
IKKA |
0.828 | 0.057 | -2 | 0.697 |
CAMK2G |
0.828 | -0.022 | 2 | 0.758 |
FAM20C |
0.828 | 0.122 | 2 | 0.642 |
JNK3 |
0.827 | 0.217 | 1 | 0.718 |
WNK1 |
0.827 | 0.025 | -2 | 0.867 |
LATS2 |
0.827 | 0.068 | -5 | 0.765 |
JNK2 |
0.827 | 0.227 | 1 | 0.678 |
CLK4 |
0.826 | 0.145 | -3 | 0.674 |
RAF1 |
0.826 | -0.095 | 1 | 0.768 |
P38B |
0.826 | 0.241 | 1 | 0.737 |
SRPK2 |
0.826 | 0.081 | -3 | 0.592 |
CDK19 |
0.826 | 0.157 | 1 | 0.699 |
NDR1 |
0.825 | 0.008 | -3 | 0.751 |
P90RSK |
0.825 | 0.038 | -3 | 0.692 |
CAMK2A |
0.825 | 0.114 | 2 | 0.762 |
GRK5 |
0.825 | -0.039 | -3 | 0.803 |
GCN2 |
0.824 | -0.188 | 2 | 0.717 |
NUAK2 |
0.824 | 0.019 | -3 | 0.755 |
DSTYK |
0.824 | -0.062 | 2 | 0.824 |
LATS1 |
0.824 | 0.195 | -3 | 0.803 |
BMPR2 |
0.823 | -0.135 | -2 | 0.822 |
HUNK |
0.823 | -0.014 | 2 | 0.782 |
CDK18 |
0.823 | 0.191 | 1 | 0.686 |
PDHK4 |
0.823 | -0.219 | 1 | 0.809 |
HIPK1 |
0.823 | 0.186 | 1 | 0.808 |
TBK1 |
0.823 | -0.121 | 1 | 0.662 |
GRK6 |
0.823 | 0.042 | 1 | 0.756 |
MAPKAPK3 |
0.822 | 0.025 | -3 | 0.684 |
CDK5 |
0.822 | 0.173 | 1 | 0.762 |
NEK6 |
0.822 | -0.035 | -2 | 0.781 |
CAMK2B |
0.822 | 0.090 | 2 | 0.751 |
CAMK2D |
0.821 | 0.016 | -3 | 0.745 |
P38A |
0.821 | 0.205 | 1 | 0.800 |
CAMLCK |
0.821 | 0.019 | -2 | 0.817 |
ULK2 |
0.821 | -0.169 | 2 | 0.694 |
TSSK2 |
0.821 | 0.054 | -5 | 0.817 |
CDK3 |
0.821 | 0.214 | 1 | 0.648 |
CLK1 |
0.821 | 0.135 | -3 | 0.647 |
GRK7 |
0.820 | 0.117 | 1 | 0.720 |
MARK4 |
0.820 | -0.003 | 4 | 0.781 |
NIK |
0.820 | -0.043 | -3 | 0.786 |
AURC |
0.820 | 0.084 | -2 | 0.634 |
ERK1 |
0.820 | 0.185 | 1 | 0.718 |
MLK1 |
0.819 | -0.078 | 2 | 0.721 |
RIPK3 |
0.819 | -0.060 | 3 | 0.638 |
IKKE |
0.818 | -0.133 | 1 | 0.655 |
GSK3A |
0.818 | 0.205 | 4 | 0.596 |
CDK7 |
0.817 | 0.124 | 1 | 0.740 |
CDK13 |
0.817 | 0.120 | 1 | 0.717 |
P38G |
0.817 | 0.173 | 1 | 0.625 |
DLK |
0.817 | -0.013 | 1 | 0.784 |
AMPKA1 |
0.817 | -0.012 | -3 | 0.765 |
RSK4 |
0.817 | 0.071 | -3 | 0.675 |
PKN3 |
0.817 | -0.054 | -3 | 0.735 |
P38D |
0.817 | 0.216 | 1 | 0.645 |
PKACB |
0.817 | 0.077 | -2 | 0.644 |
TSSK1 |
0.816 | 0.039 | -3 | 0.790 |
PRKX |
0.816 | 0.096 | -3 | 0.605 |
PKACG |
0.816 | 0.007 | -2 | 0.694 |
PKCD |
0.816 | 0.008 | 2 | 0.677 |
RSK3 |
0.816 | -0.002 | -3 | 0.673 |
PAK1 |
0.816 | 0.022 | -2 | 0.774 |
DAPK2 |
0.815 | -0.021 | -3 | 0.776 |
MST4 |
0.815 | -0.049 | 2 | 0.716 |
SRPK3 |
0.815 | 0.044 | -3 | 0.642 |
MLK2 |
0.815 | -0.020 | 2 | 0.716 |
PASK |
0.815 | 0.214 | -3 | 0.800 |
BMPR1B |
0.815 | 0.090 | 1 | 0.709 |
P70S6KB |
0.815 | -0.019 | -3 | 0.696 |
PKN2 |
0.815 | -0.038 | -3 | 0.741 |
MLK3 |
0.815 | 0.002 | 2 | 0.640 |
NEK7 |
0.814 | -0.166 | -3 | 0.780 |
AMPKA2 |
0.814 | 0.002 | -3 | 0.731 |
MSK1 |
0.813 | 0.058 | -3 | 0.658 |
MAK |
0.813 | 0.258 | -2 | 0.808 |
PDHK1 |
0.813 | -0.283 | 1 | 0.787 |
DYRK1A |
0.813 | 0.123 | 1 | 0.801 |
DYRK1B |
0.813 | 0.156 | 1 | 0.741 |
MSK2 |
0.813 | -0.003 | -3 | 0.661 |
MNK2 |
0.812 | 0.037 | -2 | 0.776 |
GRK4 |
0.812 | -0.082 | -2 | 0.730 |
ULK1 |
0.812 | -0.182 | -3 | 0.737 |
IRE1 |
0.812 | -0.049 | 1 | 0.838 |
DYRK3 |
0.812 | 0.144 | 1 | 0.814 |
ERK2 |
0.812 | 0.134 | 1 | 0.762 |
PKR |
0.810 | 0.029 | 1 | 0.842 |
PKCB |
0.810 | 0.010 | 2 | 0.632 |
RIPK1 |
0.810 | -0.120 | 1 | 0.803 |
BCKDK |
0.810 | -0.169 | -1 | 0.783 |
CDK17 |
0.810 | 0.146 | 1 | 0.630 |
MNK1 |
0.810 | 0.040 | -2 | 0.772 |
MPSK1 |
0.810 | 0.203 | 1 | 0.843 |
PAK3 |
0.809 | -0.034 | -2 | 0.773 |
CDK12 |
0.809 | 0.112 | 1 | 0.691 |
PRKD3 |
0.809 | -0.000 | -3 | 0.646 |
MASTL |
0.808 | -0.220 | -2 | 0.767 |
CK1E |
0.808 | 0.051 | -3 | 0.592 |
NIM1 |
0.808 | -0.083 | 3 | 0.715 |
CDK2 |
0.808 | 0.103 | 1 | 0.759 |
JNK1 |
0.807 | 0.177 | 1 | 0.661 |
VRK2 |
0.807 | -0.022 | 1 | 0.864 |
TGFBR1 |
0.807 | 0.010 | -2 | 0.743 |
GSK3B |
0.807 | 0.136 | 4 | 0.587 |
TGFBR2 |
0.807 | -0.155 | -2 | 0.712 |
HIPK3 |
0.807 | 0.123 | 1 | 0.794 |
NEK9 |
0.806 | -0.182 | 2 | 0.723 |
WNK3 |
0.806 | -0.264 | 1 | 0.787 |
TLK2 |
0.806 | -0.018 | 1 | 0.803 |
CDK9 |
0.806 | 0.089 | 1 | 0.719 |
ATM |
0.806 | -0.034 | 1 | 0.740 |
PRP4 |
0.805 | 0.075 | -3 | 0.693 |
ALK4 |
0.805 | -0.046 | -2 | 0.768 |
QSK |
0.805 | -0.022 | 4 | 0.744 |
PKCG |
0.804 | -0.033 | 2 | 0.642 |
PKCA |
0.804 | -0.014 | 2 | 0.617 |
PKCZ |
0.804 | -0.013 | 2 | 0.672 |
MYLK4 |
0.804 | 0.003 | -2 | 0.744 |
DNAPK |
0.804 | 0.034 | 1 | 0.660 |
AKT2 |
0.804 | 0.023 | -3 | 0.600 |
ANKRD3 |
0.804 | -0.198 | 1 | 0.809 |
PLK1 |
0.803 | -0.105 | -2 | 0.721 |
CDK16 |
0.802 | 0.147 | 1 | 0.649 |
MELK |
0.802 | -0.071 | -3 | 0.703 |
CHAK1 |
0.802 | -0.091 | 2 | 0.668 |
MLK4 |
0.802 | -0.082 | 2 | 0.632 |
BRSK1 |
0.802 | -0.051 | -3 | 0.689 |
SMG1 |
0.802 | -0.049 | 1 | 0.779 |
AURB |
0.802 | 0.013 | -2 | 0.629 |
CAMK4 |
0.802 | -0.126 | -3 | 0.719 |
MARK3 |
0.802 | -0.009 | 4 | 0.700 |
TTBK2 |
0.801 | -0.206 | 2 | 0.627 |
PKG2 |
0.801 | 0.009 | -2 | 0.642 |
PAK2 |
0.801 | -0.054 | -2 | 0.754 |
CDK14 |
0.801 | 0.123 | 1 | 0.715 |
NUAK1 |
0.801 | -0.076 | -3 | 0.687 |
PLK3 |
0.801 | -0.067 | 2 | 0.755 |
PAK6 |
0.801 | 0.004 | -2 | 0.701 |
CDK10 |
0.801 | 0.130 | 1 | 0.704 |
IRE2 |
0.801 | -0.089 | 2 | 0.651 |
DCAMKL1 |
0.800 | -0.005 | -3 | 0.694 |
PIM2 |
0.799 | 0.005 | -3 | 0.651 |
CAMK1G |
0.799 | -0.025 | -3 | 0.655 |
YSK4 |
0.799 | -0.126 | 1 | 0.722 |
ALK2 |
0.799 | -0.012 | -2 | 0.738 |
QIK |
0.799 | -0.127 | -3 | 0.736 |
MOK |
0.798 | 0.189 | 1 | 0.870 |
CK1D |
0.798 | 0.051 | -3 | 0.550 |
MEK1 |
0.798 | -0.189 | 2 | 0.767 |
SSTK |
0.798 | 0.010 | 4 | 0.725 |
CHK1 |
0.798 | -0.032 | -3 | 0.735 |
SGK3 |
0.798 | -0.015 | -3 | 0.670 |
ERK7 |
0.797 | 0.063 | 2 | 0.468 |
PKCH |
0.797 | -0.074 | 2 | 0.625 |
GRK2 |
0.797 | -0.060 | -2 | 0.632 |
CK1G1 |
0.797 | 0.005 | -3 | 0.580 |
SIK |
0.796 | -0.071 | -3 | 0.657 |
AURA |
0.796 | 0.003 | -2 | 0.599 |
GAK |
0.796 | 0.116 | 1 | 0.824 |
BRSK2 |
0.796 | -0.104 | -3 | 0.708 |
ACVR2B |
0.795 | -0.058 | -2 | 0.718 |
NEK2 |
0.794 | -0.149 | 2 | 0.695 |
PINK1 |
0.794 | -0.109 | 1 | 0.891 |
PKACA |
0.794 | 0.024 | -2 | 0.598 |
ACVR2A |
0.793 | -0.084 | -2 | 0.707 |
MEKK3 |
0.793 | -0.118 | 1 | 0.763 |
PHKG1 |
0.793 | -0.137 | -3 | 0.733 |
CK1A2 |
0.793 | 0.036 | -3 | 0.546 |
MARK2 |
0.793 | -0.073 | 4 | 0.664 |
BUB1 |
0.793 | 0.208 | -5 | 0.797 |
MST3 |
0.793 | -0.021 | 2 | 0.738 |
MAPKAPK5 |
0.793 | -0.119 | -3 | 0.612 |
BMPR1A |
0.792 | 0.021 | 1 | 0.667 |
NEK5 |
0.792 | -0.059 | 1 | 0.826 |
WNK4 |
0.791 | -0.116 | -2 | 0.853 |
DRAK1 |
0.791 | -0.057 | 1 | 0.670 |
LKB1 |
0.791 | 0.048 | -3 | 0.748 |
BRAF |
0.791 | -0.123 | -4 | 0.816 |
IRAK4 |
0.790 | -0.082 | 1 | 0.817 |
CAMK1D |
0.789 | -0.013 | -3 | 0.582 |
MARK1 |
0.789 | -0.083 | 4 | 0.722 |
TAO3 |
0.789 | -0.050 | 1 | 0.760 |
TLK1 |
0.789 | -0.129 | -2 | 0.744 |
MEK5 |
0.789 | -0.236 | 2 | 0.737 |
PERK |
0.789 | -0.189 | -2 | 0.758 |
CAMKK1 |
0.788 | -0.047 | -2 | 0.735 |
MEKK2 |
0.788 | -0.137 | 2 | 0.709 |
SMMLCK |
0.788 | -0.047 | -3 | 0.717 |
SNRK |
0.788 | -0.215 | 2 | 0.632 |
DCAMKL2 |
0.788 | -0.069 | -3 | 0.709 |
AKT1 |
0.788 | -0.008 | -3 | 0.618 |
PLK4 |
0.787 | -0.143 | 2 | 0.591 |
CDK6 |
0.787 | 0.106 | 1 | 0.695 |
ZAK |
0.787 | -0.174 | 1 | 0.737 |
GRK3 |
0.786 | -0.044 | -2 | 0.579 |
MEKK1 |
0.786 | -0.206 | 1 | 0.777 |
CAMKK2 |
0.785 | -0.024 | -2 | 0.741 |
CDK4 |
0.784 | 0.097 | 1 | 0.681 |
DAPK3 |
0.783 | -0.002 | -3 | 0.708 |
CK2A2 |
0.783 | 0.013 | 1 | 0.594 |
PLK2 |
0.783 | -0.012 | -3 | 0.707 |
PKCT |
0.783 | -0.085 | 2 | 0.622 |
HRI |
0.783 | -0.260 | -2 | 0.775 |
PKCE |
0.782 | -0.016 | 2 | 0.624 |
P70S6K |
0.782 | -0.080 | -3 | 0.601 |
GCK |
0.781 | -0.003 | 1 | 0.744 |
EEF2K |
0.781 | -0.014 | 3 | 0.793 |
PKCI |
0.780 | -0.073 | 2 | 0.634 |
PDK1 |
0.780 | -0.093 | 1 | 0.746 |
NEK8 |
0.779 | -0.181 | 2 | 0.722 |
LRRK2 |
0.779 | -0.064 | 2 | 0.750 |
TNIK |
0.779 | -0.007 | 3 | 0.831 |
NEK11 |
0.779 | -0.168 | 1 | 0.742 |
MAP3K15 |
0.778 | -0.056 | 1 | 0.730 |
SGK1 |
0.778 | 0.005 | -3 | 0.528 |
MEKK6 |
0.778 | -0.079 | 1 | 0.804 |
AKT3 |
0.778 | 0.002 | -3 | 0.551 |
SBK |
0.778 | 0.022 | -3 | 0.486 |
VRK1 |
0.777 | -0.050 | 2 | 0.762 |
CK2A1 |
0.777 | 0.019 | 1 | 0.567 |
DAPK1 |
0.777 | -0.010 | -3 | 0.690 |
PAK4 |
0.776 | -0.035 | -2 | 0.637 |
ROCK2 |
0.776 | 0.026 | -3 | 0.695 |
PAK5 |
0.776 | -0.060 | -2 | 0.628 |
STK33 |
0.775 | -0.103 | 2 | 0.575 |
TAK1 |
0.775 | -0.070 | 1 | 0.782 |
TAO2 |
0.774 | -0.170 | 2 | 0.735 |
PHKG2 |
0.774 | -0.166 | -3 | 0.687 |
PDHK3_TYR |
0.774 | 0.353 | 4 | 0.903 |
HGK |
0.774 | -0.086 | 3 | 0.818 |
MRCKA |
0.774 | -0.006 | -3 | 0.650 |
CAMK1A |
0.774 | -0.028 | -3 | 0.558 |
MST2 |
0.773 | -0.121 | 1 | 0.749 |
CHK2 |
0.773 | -0.045 | -3 | 0.540 |
MINK |
0.773 | -0.102 | 1 | 0.748 |
NEK4 |
0.772 | -0.175 | 1 | 0.766 |
NEK1 |
0.771 | -0.085 | 1 | 0.789 |
HPK1 |
0.771 | -0.074 | 1 | 0.723 |
MRCKB |
0.771 | -0.016 | -3 | 0.631 |
TTBK1 |
0.771 | -0.229 | 2 | 0.567 |
DMPK1 |
0.771 | 0.043 | -3 | 0.665 |
PDHK4_TYR |
0.770 | 0.275 | 2 | 0.824 |
HASPIN |
0.769 | 0.046 | -1 | 0.747 |
KHS1 |
0.769 | -0.046 | 1 | 0.731 |
PBK |
0.769 | -0.001 | 1 | 0.763 |
SLK |
0.769 | -0.077 | -2 | 0.656 |
CK1A |
0.769 | 0.027 | -3 | 0.472 |
KHS2 |
0.768 | -0.029 | 1 | 0.738 |
IRAK1 |
0.767 | -0.320 | -1 | 0.736 |
LOK |
0.766 | -0.125 | -2 | 0.725 |
MST1 |
0.766 | -0.128 | 1 | 0.741 |
CRIK |
0.765 | 0.012 | -3 | 0.631 |
PKN1 |
0.764 | -0.110 | -3 | 0.620 |
YANK3 |
0.764 | -0.041 | 2 | 0.399 |
OSR1 |
0.763 | -0.059 | 2 | 0.691 |
MAP2K6_TYR |
0.762 | 0.133 | -1 | 0.867 |
ALPHAK3 |
0.761 | -0.004 | -1 | 0.782 |
TESK1_TYR |
0.760 | 0.035 | 3 | 0.827 |
PDHK1_TYR |
0.760 | 0.077 | -1 | 0.879 |
ROCK1 |
0.759 | -0.017 | -3 | 0.645 |
YSK1 |
0.758 | -0.166 | 2 | 0.683 |
MAP2K4_TYR |
0.758 | 0.024 | -1 | 0.862 |
BIKE |
0.758 | 0.017 | 1 | 0.713 |
LIMK2_TYR |
0.758 | 0.081 | -3 | 0.809 |
BMPR2_TYR |
0.757 | 0.049 | -1 | 0.857 |
ASK1 |
0.756 | -0.100 | 1 | 0.713 |
MAP2K7_TYR |
0.755 | -0.112 | 2 | 0.790 |
TTK |
0.754 | -0.119 | -2 | 0.735 |
PKMYT1_TYR |
0.754 | -0.047 | 3 | 0.778 |
MYO3B |
0.753 | -0.077 | 2 | 0.695 |
MEK2 |
0.752 | -0.333 | 2 | 0.713 |
PKG1 |
0.751 | -0.083 | -2 | 0.573 |
RIPK2 |
0.751 | -0.338 | 1 | 0.680 |
PINK1_TYR |
0.751 | -0.159 | 1 | 0.826 |
ABL2 |
0.749 | 0.098 | -1 | 0.816 |
EPHA6 |
0.747 | 0.021 | -1 | 0.838 |
AAK1 |
0.747 | 0.069 | 1 | 0.627 |
RET |
0.746 | -0.094 | 1 | 0.785 |
EPHB4 |
0.746 | 0.035 | -1 | 0.803 |
ABL1 |
0.744 | 0.084 | -1 | 0.809 |
MYO3A |
0.744 | -0.147 | 1 | 0.769 |
NEK3 |
0.744 | -0.269 | 1 | 0.747 |
LIMK1_TYR |
0.743 | -0.164 | 2 | 0.751 |
CK1G3 |
0.743 | 0.003 | -3 | 0.428 |
DDR1 |
0.742 | -0.082 | 4 | 0.807 |
CSF1R |
0.741 | -0.074 | 3 | 0.691 |
TAO1 |
0.740 | -0.186 | 1 | 0.694 |
EPHA4 |
0.740 | 0.009 | 2 | 0.771 |
FGR |
0.740 | -0.035 | 1 | 0.824 |
TNK2 |
0.739 | 0.015 | 3 | 0.636 |
TXK |
0.739 | 0.048 | 1 | 0.740 |
TYRO3 |
0.739 | -0.126 | 3 | 0.713 |
YES1 |
0.738 | -0.039 | -1 | 0.829 |
MST1R |
0.737 | -0.192 | 3 | 0.711 |
JAK2 |
0.736 | -0.168 | 1 | 0.774 |
TYK2 |
0.736 | -0.248 | 1 | 0.781 |
ITK |
0.736 | 0.016 | -1 | 0.763 |
KIT |
0.736 | -0.076 | 3 | 0.693 |
JAK3 |
0.735 | -0.130 | 1 | 0.765 |
TNK1 |
0.735 | -0.043 | 3 | 0.698 |
ROS1 |
0.734 | -0.183 | 3 | 0.673 |
STLK3 |
0.734 | -0.236 | 1 | 0.704 |
FER |
0.733 | -0.118 | 1 | 0.798 |
SRMS |
0.733 | -0.028 | 1 | 0.770 |
INSRR |
0.732 | -0.133 | 3 | 0.639 |
EPHB1 |
0.732 | -0.048 | 1 | 0.774 |
FGFR2 |
0.732 | -0.140 | 3 | 0.684 |
MET |
0.730 | -0.080 | 3 | 0.680 |
DDR2 |
0.730 | 0.029 | 3 | 0.608 |
KDR |
0.729 | -0.139 | 3 | 0.639 |
YANK2 |
0.729 | -0.070 | 2 | 0.414 |
BLK |
0.729 | 0.004 | -1 | 0.807 |
EPHB2 |
0.729 | -0.046 | -1 | 0.776 |
HCK |
0.729 | -0.099 | -1 | 0.792 |
EPHB3 |
0.729 | -0.058 | -1 | 0.783 |
BMX |
0.729 | -0.003 | -1 | 0.705 |
FYN |
0.729 | 0.020 | -1 | 0.784 |
LCK |
0.728 | -0.045 | -1 | 0.800 |
TNNI3K_TYR |
0.727 | -0.076 | 1 | 0.825 |
CK1G2 |
0.727 | -0.002 | -3 | 0.507 |
FLT1 |
0.727 | -0.093 | -1 | 0.820 |
NEK10_TYR |
0.726 | -0.160 | 1 | 0.668 |
MERTK |
0.726 | -0.081 | 3 | 0.665 |
WEE1_TYR |
0.726 | -0.096 | -1 | 0.743 |
FLT3 |
0.725 | -0.205 | 3 | 0.702 |
PDGFRB |
0.725 | -0.238 | 3 | 0.703 |
MATK |
0.724 | -0.068 | -1 | 0.770 |
EPHA3 |
0.723 | -0.092 | 2 | 0.734 |
AXL |
0.723 | -0.153 | 3 | 0.660 |
FGFR3 |
0.722 | -0.132 | 3 | 0.651 |
EPHA7 |
0.722 | -0.068 | 2 | 0.758 |
TEC |
0.722 | -0.084 | -1 | 0.714 |
FGFR1 |
0.721 | -0.218 | 3 | 0.645 |
JAK1 |
0.721 | -0.170 | 1 | 0.706 |
TEK |
0.720 | -0.205 | 3 | 0.631 |
BTK |
0.719 | -0.186 | -1 | 0.731 |
CSK |
0.718 | -0.089 | 2 | 0.753 |
PTK2 |
0.718 | 0.019 | -1 | 0.759 |
PTK2B |
0.718 | -0.031 | -1 | 0.758 |
LTK |
0.718 | -0.155 | 3 | 0.623 |
NTRK1 |
0.717 | -0.218 | -1 | 0.807 |
PDGFRA |
0.717 | -0.298 | 3 | 0.705 |
PTK6 |
0.717 | -0.229 | -1 | 0.725 |
EPHA5 |
0.717 | -0.060 | 2 | 0.766 |
LYN |
0.716 | -0.092 | 3 | 0.607 |
SRC |
0.716 | -0.062 | -1 | 0.792 |
ERBB2 |
0.716 | -0.206 | 1 | 0.708 |
EGFR |
0.715 | -0.092 | 1 | 0.622 |
FGFR4 |
0.715 | -0.084 | -1 | 0.765 |
SYK |
0.715 | -0.004 | -1 | 0.754 |
FLT4 |
0.715 | -0.220 | 3 | 0.637 |
FRK |
0.714 | -0.142 | -1 | 0.803 |
INSR |
0.713 | -0.197 | 3 | 0.622 |
ALK |
0.713 | -0.230 | 3 | 0.599 |
EPHA8 |
0.712 | -0.095 | -1 | 0.783 |
NTRK3 |
0.711 | -0.165 | -1 | 0.767 |
EPHA1 |
0.710 | -0.189 | 3 | 0.647 |
NTRK2 |
0.707 | -0.297 | 3 | 0.631 |
EPHA2 |
0.707 | -0.070 | -1 | 0.743 |
ERBB4 |
0.702 | -0.077 | 1 | 0.628 |
IGF1R |
0.702 | -0.162 | 3 | 0.560 |
ZAP70 |
0.699 | -0.011 | -1 | 0.701 |
MUSK |
0.696 | -0.200 | 1 | 0.640 |
FES |
0.683 | -0.173 | -1 | 0.695 |