Motif 250 (n=243)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX86 | GOLGA8Q | S77 | ochoa | Golgin A8 family member Q | None |
| A0A1W2PPC1 | PRR33 | S280 | ochoa | Proline rich 33 | None |
| A2A288 | ZC3H12D | S336 | ochoa | Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) | May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}. |
| A6NJ78 | METTL15 | S85 | ochoa | 12S rRNA N(4)-cytidine methyltransferase METTL15 (12S rRNA m4C methyltransferase) (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) (Methyltransferase-like protein 15) | N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392). {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}. |
| A6NMD2 | GOLGA8J | S77 | ochoa | Golgin subfamily A member 8J | None |
| A7KAX9 | ARHGAP32 | S1720 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8CG34 | POM121C | S190 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| A8MZF0 | PRR33 | S132 | ochoa | Proline-rich protein 33 | None |
| B4DS77 | SHISA9 | S337 | ochoa | Protein shisa-9 | Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). {ECO:0000250}. |
| D6RIA3 | C4orf54 | S1707 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| E7EW31 | PROB1 | S862 | ochoa | Proline-rich basic protein 1 | None |
| H3BQL2 | GOLGA8T | S77 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S77 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S77 | ochoa | Golgin subfamily A member 8R | None |
| K7EQG2 | None | S98 | ochoa | Uncharacterized protein | None |
| M0R1X1 | None | S75 | ochoa | KRAB domain-containing protein | None |
| O00358 | FOXE1 | S308 | ochoa | Forkhead box protein E1 (Forkhead box protein E2) (Forkhead-related protein FKHL15) (HFKH4) (HNF-3/fork head-like protein 5) (HFKL5) (Thyroid transcription factor 2) (TTF-2) | Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. {ECO:0000269|PubMed:12165566, ECO:0000269|PubMed:16882747, ECO:0000269|PubMed:20094846, ECO:0000269|PubMed:20484477, ECO:0000269|PubMed:21177256, ECO:0000269|PubMed:24219130, ECO:0000269|PubMed:25381600, ECO:0000269|PubMed:9697705}. |
| O14654 | IRS4 | S804 | psp | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14939 | PLD2 | S146 | psp | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15027 | SEC16A | S2183 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15119 | TBX3 | S680 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15446 | POLR1G | S27 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O15534 | PER1 | S1031 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43303 | CCP110 | S516 | ochoa|psp | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}. |
| O43379 | WDR62 | S1388 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60237 | PPP1R12B | S735 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60281 | ZNF292 | S1159 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60762 | DPM1 | S21 | ochoa | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. {ECO:0000269|PubMed:10835346}. |
| O75376 | NCOR1 | S158 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S1545 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75643 | SNRNP200 | S932 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75746 | SLC25A12 | S312 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:38945283}. |
| O75815 | BCAR3 | S375 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O94855 | SEC24D | S22 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94868 | FCHSD2 | S693 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94967 | WDR47 | S297 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95049 | TJP3 | S378 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95104 | SCAF4 | S154 | ochoa | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| O95359 | TACC2 | S1635 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S2226 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95600 | KLF8 | S48 | psp | Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741) | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}. |
| O95613 | PCNT | S3274 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95817 | BAG3 | S173 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95863 | SNAI1 | S82 | psp | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| P09923 | ALPI | S174 | ochoa | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P0C7V9 | METTL15P1 | S85 | ochoa | Putative methyltransferase-like protein 15P1 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 2) (Methyltransferase-like protein 15 pseudogene 1) | Probable S-adenosyl-L-methionine-dependent methyltransferase. {ECO:0000250}. |
| P0CJ92 | GOLGA8H | S77 | ochoa | Golgin subfamily A member 8H | None |
| P10746 | UROS | S245 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P12755 | SKI | S432 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P12931 | SRC | S75 | ochoa|psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P15822 | HIVEP1 | S2353 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P15976 | GATA1 | S116 | ochoa | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
| P17535 | JUND | S90 | ochoa | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
| P19419 | ELK1 | S304 | ochoa | ETS domain-containing protein Elk-1 | Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}. |
| P21333 | FLNA | S2370 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P26358 | DNMT1 | S954 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P35670 | ATP7B | S478 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P35711 | SOX5 | S439 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P35712 | SOX6 | S411 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P41182 | BCL6 | S427 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P41225 | SOX3 | S380 | ochoa | Transcription factor SOX-3 | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:21183788}. |
| P42695 | NCAPD3 | S1329 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P42695 | NCAPD3 | S1474 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P48436 | SOX9 | S211 | ochoa|psp | Transcription factor SOX-9 | Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}. |
| P49674 | CSNK1E | S363 | ochoa | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P50219 | MNX1 | S77 | ochoa | Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) | Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250|UniProtKB:Q9QZW9}. |
| P51003 | PAPOLA | S654 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51610 | HCFC1 | S984 | ochoa|psp | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51610 | HCFC1 | S1902 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P56524 | HDAC4 | S400 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P57059 | SIK1 | S534 | ochoa | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| P78559 | MAP1A | S2629 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00536 | CDK16 | S138 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00537 | CDK17 | S165 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q01518 | CAP1 | S308 | ochoa|psp | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q02078 | MEF2A | S235 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03060 | CREM | S277 | psp | cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER) | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}. |
| Q03188 | CENPC | S538 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06413 | MEF2C | S240 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q12788 | TBL3 | S257 | ochoa | Transducin beta-like protein 3 (WD repeat-containing protein SAZD) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q12796 | PNRC1 | S105 | ochoa | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | Nuclear receptor coactivator. May play a role in signal transduction. {ECO:0000269|PubMed:10894149}. |
| Q12830 | BPTF | S2471 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13495 | MAMLD1 | S412 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13501 | SQSTM1 | S207 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13522 | PPP1R1A | S67 | ochoa|psp | Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
| Q13613 | MTMR1 | S39 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q14676 | MDC1 | S793 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14789 | GOLGB1 | S1148 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q147X3 | NAA30 | S89 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14938 | NFIX | S361 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15386 | UBE3C | S672 | ochoa | Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) | E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24158444, PubMed:24811749, PubMed:25752573, PubMed:25752577, PubMed:32039437, PubMed:33637724, PubMed:34239127). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32039437, PubMed:9575161). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129). {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690, ECO:0000269|PubMed:21167755, ECO:0000269|PubMed:24158444, ECO:0000269|PubMed:24811749, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:31375563, ECO:0000269|PubMed:32039437, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:9575161}. |
| Q15477 | SKIC2 | S245 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
| Q15569 | TESK1 | S553 | ochoa | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q15742 | NAB2 | S171 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15772 | SPEG | S2004 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16584 | MAP3K11 | S548 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q3MIN7 | RGL3 | S52 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q4KMP7 | TBC1D10B | S22 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q4ZG55 | GREB1 | S1160 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q587I9 | SFT2D3 | S56 | ochoa | Vesicle transport protein SFT2C (SFT2 domain-containing protein 3) | May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. {ECO:0000250|UniProtKB:P38166}. |
| Q58A45 | PAN3 | S192 | ochoa | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}. |
| Q58EX7 | PLEKHG4 | S716 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5JTD0 | TJAP1 | S449 | ochoa | Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) | Plays a role in regulating the structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q9DCD5}. |
| Q5JVF3 | PCID2 | S45 | ochoa | PCI domain-containing protein 2 (CSN12-like protein) | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}. |
| Q5T035 | FAM120A2P | Y42 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T2W1 | PDZK1 | S364 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). {ECO:0000250}. |
| Q5TGY3 | AHDC1 | S596 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TKA1 | LIN9 | S321 | ochoa|psp | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VV67 | PPRC1 | S1063 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5XPI4 | RNF123 | S675 | ochoa | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) | Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:27312109, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}. |
| Q641Q2 | WASHC2A | S1169 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q66K74 | MAP1S | S731 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DI1 | ZNF776 | S75 | ochoa | Zinc finger protein 776 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6GTX8 | LAIR1 | S268 | ochoa | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305) | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. {ECO:0000269|PubMed:10229813, ECO:0000269|PubMed:10764762, ECO:0000269|PubMed:11069054, ECO:0000269|PubMed:11160222, ECO:0000269|PubMed:12072189, ECO:0000269|PubMed:15939744, ECO:0000269|PubMed:15950745, ECO:0000269|PubMed:16380958, ECO:0000269|PubMed:9285412, ECO:0000269|PubMed:9692876}. |
| Q6IBW4 | NCAPH2 | S284 | ochoa|psp | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6PIF6 | MYO7B | S934 | ochoa | Unconventional myosin-VIIb | Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length (PubMed:24725409, PubMed:26812018, PubMed:32209652). May link the complex to the actin core bundle of microvilli. {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652, ECO:0000305|PubMed:24725409, ECO:0000305|PubMed:26812018}. |
| Q6PJW8 | CNST | S348 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6ZN30 | BNC2 | S937 | ochoa | Zinc finger protein basonuclin-2 | Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}. |
| Q6ZRI6 | C15orf39 | S996 | ochoa | Uncharacterized protein C15orf39 | None |
| Q70EL1 | USP54 | S632 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7L5Y9 | MAEA | S311 | ochoa | E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}. |
| Q7Z4K8 | TRIM46 | S88 | ochoa | Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}. |
| Q7Z589 | EMSY | S1213 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86SQ0 | PHLDB2 | S334 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UE8 | TLK2 | S111 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UR5 | RIMS1 | S1613 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86UU1 | PHLDB1 | S157 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86UU1 | PHLDB1 | S334 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86YP4 | GATAD2A | S598 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q86YR5 | GPSM1 | S545 | ochoa | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Q86YV5 | PRAG1 | S492 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IUD2 | ERC1 | S110 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IUE0 | TGIF2LY | S25 | ochoa | Homeobox protein TGIF2LY (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, Y-linked) (TGIF-like on the Y) | May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX. |
| Q8IUE1 | TGIF2LX | S25 | ochoa | Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X) | May have a transcription role in testis. |
| Q8IVB4 | SLC9A9 | S612 | ochoa | Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:15522866, PubMed:24065030, PubMed:28130443). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (PubMed:28130443). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity). {ECO:0000250|UniProtKB:Q8BZ00, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:28130443, ECO:0000305|PubMed:15522866}. |
| Q8IWC1 | MAP7D3 | S533 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX07 | ZFPM1 | S128 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX21 | SLF2 | S653 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IY67 | RAVER1 | S524 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IY92 | SLX4 | S960 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYN6 | UBALD2 | S116 | ochoa | UBA-like domain-containing protein 2 | None |
| Q8NEY1 | NAV1 | S1265 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEY1 | NAV1 | S1826 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NFQ8 | TOR1AIP2 | S163 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
| Q8NI77 | KIF18A | S684 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TB24 | RIN3 | S524 | ochoa | Ras and Rab interactor 3 (Ras interaction/interference protein 3) | Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}. |
| Q8TBC5 | ZSCAN18 | S168 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TCU6 | PREX1 | S839 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TES7 | FBF1 | S334 | ochoa|psp | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8WUY3 | PRUNE2 | S620 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WXF1 | PSPC1 | S409 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Q8WXI9 | GATAD2B | S223 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92560 | BAP1 | S369 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92560 | BAP1 | S521 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92615 | LARP4B | S434 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92615 | LARP4B | S488 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92619 | ARHGAP45 | S54 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92619 | ARHGAP45 | S99 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92766 | RREB1 | S1140 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92974 | ARHGEF2 | S648 | ochoa | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q96AQ6 | PBXIP1 | S43 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96D05 | FAM241B | S62 | ochoa | Protein FAM241B | May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}. |
| Q96EG3 | ZNF837 | S351 | ochoa | Zinc finger protein 837 | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q96EV2 | RBM33 | S741 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96F24 | NRBF2 | S268 | ochoa | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q96FS4 | SIPA1 | S79 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96GE9 | DMAC1 | S37 | ochoa | Distal membrane-arm assembly complex protein 1 (Transmembrane protein 261) | Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}. |
| Q96JH8 | RADIL | S393 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96JK2 | DCAF5 | S496 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96N21 | TEPSIN | S455 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96NM4 | TOX2 | S351 | ochoa | TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) | Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. |
| Q96PU5 | NEDD4L | S303 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96PY6 | NEK1 | S806 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96QE3 | ATAD5 | S1244 | ochoa | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | Has an important role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). {ECO:0000269|PubMed:15983387, ECO:0000269|PubMed:19755857, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:23277426, ECO:0000269|PubMed:23937667, ECO:0000269|PubMed:31844045}. |
| Q96QT4 | TRPM7 | S1543 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T58 | SPEN | S2493 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99501 | GAS2L1 | S429 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99650 | OSMR | S889 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Q99704 | DOK1 | S291 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q99708 | RBBP8 | S327 | ochoa|psp | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99990 | VGLL1 | S116 | ochoa | Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000269|PubMed:10518497}. |
| Q9BSJ5 | MTNAP1 | S442 | ochoa | Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) | Critical regulator of mitochondrial DNA (mtDNA) abundance (PubMed:37676315). Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (PubMed:37676315). Also plays important roles in mitochondrial metabolism and cell proliferation (PubMed:37676315). {ECO:0000269|PubMed:37676315}. |
| Q9BTC0 | DIDO1 | S1714 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BW71 | HIRIP3 | S125 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BWG4 | SSBP4 | S350 | ochoa | Single-stranded DNA-binding protein 4 | None |
| Q9BX63 | BRIP1 | S1032 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BX95 | SGPP1 | S101 | ochoa | Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) | Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:11756451, PubMed:12815058, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:18583713, PubMed:20798685). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9JI99, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12815058, ECO:0000269|PubMed:16782891, ECO:0000269|PubMed:18583713, ECO:0000269|PubMed:20798685}. |
| Q9C0C2 | TNKS1BP1 | S275 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S97 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZN2 | TGIF2 | S153 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
| Q9GZU1 | MCOLN1 | S29 | ochoa | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}. |
| Q9H2D6 | TRIOBP | S638 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S662 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S710 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S805 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S1955 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H4G0 | EPB41L1 | S784 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H6S1 | AZI2 | S301 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9HAW0 | BRF2 | S365 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
| Q9HAW4 | CLSPN | S846 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HCC9 | ZFYVE28 | S384 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9HCE3 | ZNF532 | S434 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCI5 | MAGEE1 | S467 | ochoa | Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| Q9NP08 | HMX1 | S129 | ochoa | Homeobox protein HMX1 (Homeobox protein H6) | DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269|PubMed:10206974}. |
| Q9NRJ4 | TULP4 | S577 | ochoa | Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}. |
| Q9NZB2 | FAM120A | Y393 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P0V3 | SH3BP4 | S271 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P206 | NHSL3 | S286 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P219 | CCDC88C | S1847 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2F8 | SIPA1L2 | S1081 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2S5 | WRAP73 | S281 | ochoa | WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) | The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. |
| Q9UKK3 | PARP4 | S1306 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKK3 | PARP4 | S1489 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKV3 | ACIN1 | S490 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULD2 | MTUS1 | S541 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD4 | BRPF3 | S400 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULD5 | ZNF777 | S143 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9ULI4 | KIF26A | S1376 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULM3 | YEATS2 | S367 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULU8 | CADPS | S91 | ochoa | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}. |
| Q9UPN4 | CEP131 | S417 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPT8 | ZC3H4 | S1114 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQF2 | MAPK8IP1 | S29 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y261 | FOXA2 | S309 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2F5 | ICE1 | S1331 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K7 | KDM2A | S740 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2W2 | WBP11 | S237 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y3L3 | SH3BP1 | S550 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3S1 | WNK2 | S1777 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y4B5 | MTCL1 | S1679 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4C1 | KDM3A | S325 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| Q9Y4E6 | WDR7 | S1063 | ochoa | WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG) | None |
| Q9Y4F5 | CEP170B | S1545 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4I1 | MYO5A | S600 | ochoa | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin) | Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (PubMed:10448864). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation (By similarity). {ECO:0000250|UniProtKB:Q99104, ECO:0000250|UniProtKB:Q9QYF3, ECO:0000269|PubMed:10448864}. |
| Q9Y666 | SLC12A7 | S50 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6K1 | DNMT3A | S255 | ochoa|psp | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
| Q96RT7 | TUBGCP6 | S1087 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1114 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1168 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1195 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RT7 | TUBGCP6 | S1249 | SIGNOR | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q9H488 | POFUT1 | S264 | Sugiyama | GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) | Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). {ECO:0000269|PubMed:11524432, ECO:0000269|PubMed:28334865, ECO:0000269|PubMed:8358148}. |
| Q9H0B6 | KLC2 | S374 | Sugiyama | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000184 | 3.736 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.007465 | 2.127 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.003430 | 2.465 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.004847 | 2.315 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.001969 | 2.706 |
| R-HSA-9909396 | Circadian clock | 0.002875 | 2.541 |
| R-HSA-198753 | ERK/MAPK targets | 0.008680 | 2.062 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.003430 | 2.465 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.008672 | 2.062 |
| R-HSA-166520 | Signaling by NTRKs | 0.005657 | 2.247 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.010212 | 1.991 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.010592 | 1.975 |
| R-HSA-380287 | Centrosome maturation | 0.011249 | 1.949 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.011423 | 1.942 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.016800 | 1.775 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.012974 | 1.887 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.016110 | 1.793 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.020078 | 1.697 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.019082 | 1.719 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.020555 | 1.687 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.022032 | 1.657 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.022199 | 1.654 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.027938 | 1.554 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.027938 | 1.554 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.027477 | 1.561 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.026895 | 1.570 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.025215 | 1.598 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.025215 | 1.598 |
| R-HSA-983189 | Kinesins | 0.024376 | 1.613 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.024376 | 1.613 |
| R-HSA-1640170 | Cell Cycle | 0.025875 | 1.587 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.023712 | 1.625 |
| R-HSA-5619052 | Defective SLC9A9 causes autism 16 (AUTS16) | 0.046755 | 1.330 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.061851 | 1.209 |
| R-HSA-4719377 | Defective DPM2 causes DPM2-CDG | 0.076709 | 1.115 |
| R-HSA-4719360 | Defective DPM3 causes DPM3-CDG | 0.076709 | 1.115 |
| R-HSA-4717374 | Defective DPM1 causes DPM1-CDG | 0.076709 | 1.115 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.119891 | 0.921 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.030700 | 1.513 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.056941 | 1.245 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.061157 | 1.214 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.061157 | 1.214 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.061157 | 1.214 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.061157 | 1.214 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.212985 | 0.672 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.088470 | 1.053 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.225458 | 0.647 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.237734 | 0.624 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.108310 | 0.965 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.113440 | 0.945 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.031793 | 1.498 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.118632 | 0.926 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.118632 | 0.926 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.035946 | 1.444 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.129188 | 0.889 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.129188 | 0.889 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.134545 | 0.871 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.273410 | 0.563 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.145405 | 0.837 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.051951 | 1.284 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.296266 | 0.528 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.096248 | 1.017 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.167624 | 0.776 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.173267 | 0.761 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.329213 | 0.483 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.159503 | 0.797 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.288472 | 0.540 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.055549 | 1.255 |
| R-HSA-3928664 | Ephrin signaling | 0.307424 | 0.512 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.339851 | 0.469 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.213499 | 0.671 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.213499 | 0.671 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.213499 | 0.671 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.343718 | 0.464 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.147555 | 0.831 |
| R-HSA-354192 | Integrin signaling | 0.129188 | 0.889 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.044957 | 1.347 |
| R-HSA-5693538 | Homology Directed Repair | 0.062014 | 1.208 |
| R-HSA-191650 | Regulation of gap junction activity | 0.091333 | 1.039 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.360624 | 0.443 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.052932 | 1.276 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.225458 | 0.647 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.133552 | 0.874 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.207689 | 0.683 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.167624 | 0.776 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.213499 | 0.671 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.353736 | 0.451 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.046866 | 1.329 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.064142 | 1.193 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.261707 | 0.582 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.129188 | 0.889 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.213499 | 0.671 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.289769 | 0.538 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.159503 | 0.797 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.360624 | 0.443 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.058103 | 1.236 |
| R-HSA-174577 | Activation of C3 and C5 | 0.105726 | 0.976 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.080948 | 1.092 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.284929 | 0.545 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.151935 | 0.818 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.119452 | 0.923 |
| R-HSA-5334118 | DNA methylation | 0.108310 | 0.965 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.096248 | 1.017 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.096248 | 1.017 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.096248 | 1.017 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.096248 | 1.017 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.359464 | 0.444 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.139952 | 0.854 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.336448 | 0.473 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.076709 | 1.115 |
| R-HSA-162699 | Synthesis of dolichyl-phosphate mannose | 0.119891 | 0.921 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.147555 | 0.831 |
| R-HSA-429947 | Deadenylation of mRNA | 0.083698 | 1.077 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.212985 | 0.672 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.134545 | 0.871 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.139952 | 0.854 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.150901 | 0.821 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.156438 | 0.806 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.307424 | 0.512 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.307424 | 0.512 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.173267 | 0.761 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.207689 | 0.683 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.307424 | 0.512 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.061157 | 1.214 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.261707 | 0.582 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.225458 | 0.647 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.270859 | 0.567 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.200312 | 0.698 |
| R-HSA-171007 | p38MAPK events | 0.261707 | 0.582 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.134545 | 0.871 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.162013 | 0.790 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.307424 | 0.512 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.329213 | 0.483 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.360624 | 0.443 |
| R-HSA-9707616 | Heme signaling | 0.307350 | 0.512 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.249816 | 0.602 |
| R-HSA-9663891 | Selective autophagy | 0.202970 | 0.693 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.342226 | 0.466 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.173267 | 0.761 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.173267 | 0.761 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.212985 | 0.672 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.307424 | 0.512 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.318405 | 0.497 |
| R-HSA-9710421 | Defective pyroptosis | 0.196123 | 0.707 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.339851 | 0.469 |
| R-HSA-191859 | snRNP Assembly | 0.289769 | 0.538 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.289769 | 0.538 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.301498 | 0.521 |
| R-HSA-68877 | Mitotic Prometaphase | 0.055453 | 1.256 |
| R-HSA-9664873 | Pexophagy | 0.187436 | 0.727 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.150901 | 0.821 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.096248 | 1.017 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.151935 | 0.818 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.038193 | 1.418 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.093099 | 1.031 |
| R-HSA-9733709 | Cardiogenesis | 0.129188 | 0.889 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.237734 | 0.624 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.249816 | 0.602 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.139952 | 0.854 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.145405 | 0.837 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.213499 | 0.671 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.360624 | 0.443 |
| R-HSA-68875 | Mitotic Prophase | 0.168020 | 0.775 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.105726 | 0.976 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.147555 | 0.831 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.147555 | 0.831 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.147555 | 0.831 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.161061 | 0.793 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.161061 | 0.793 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.174353 | 0.759 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.225458 | 0.647 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.225458 | 0.647 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.273410 | 0.563 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.173267 | 0.761 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.173267 | 0.761 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.178941 | 0.747 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.144486 | 0.840 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.313193 | 0.504 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.150901 | 0.821 |
| R-HSA-3214842 | HDMs demethylate histones | 0.088470 | 1.053 |
| R-HSA-68886 | M Phase | 0.060682 | 1.217 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.185314 | 0.732 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.090243 | 1.045 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.061516 | 1.211 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.055549 | 1.255 |
| R-HSA-69275 | G2/M Transition | 0.047991 | 1.319 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.248786 | 0.604 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.050053 | 1.301 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.350320 | 0.456 |
| R-HSA-69481 | G2/M Checkpoints | 0.193178 | 0.714 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.173267 | 0.761 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.119891 | 0.921 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.037566 | 1.425 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.161061 | 0.793 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.174353 | 0.759 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.225458 | 0.647 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.225458 | 0.647 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.225458 | 0.647 |
| R-HSA-1483148 | Synthesis of PG | 0.284929 | 0.545 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.162013 | 0.790 |
| R-HSA-167044 | Signalling to RAS | 0.339851 | 0.469 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.213499 | 0.671 |
| R-HSA-3214847 | HATs acetylate histones | 0.257289 | 0.590 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.158907 | 0.799 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.037622 | 1.425 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.261707 | 0.582 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.093694 | 1.028 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.257289 | 0.590 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.140809 | 0.851 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.159503 | 0.797 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.270117 | 0.568 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.097239 | 1.012 |
| R-HSA-5205647 | Mitophagy | 0.139952 | 0.854 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.207689 | 0.683 |
| R-HSA-5673000 | RAF activation | 0.139952 | 0.854 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.145405 | 0.837 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.284929 | 0.545 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.167624 | 0.776 |
| R-HSA-9758941 | Gastrulation | 0.130948 | 0.883 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.359464 | 0.444 |
| R-HSA-5617833 | Cilium Assembly | 0.243118 | 0.614 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.159225 | 0.798 |
| R-HSA-9659379 | Sensory processing of sound | 0.051951 | 1.284 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.350320 | 0.456 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.278018 | 0.556 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.089982 | 1.046 |
| R-HSA-9675135 | Diseases of DNA repair | 0.213499 | 0.671 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.161061 | 0.793 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.187436 | 0.727 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.187436 | 0.727 |
| R-HSA-210990 | PECAM1 interactions | 0.200312 | 0.698 |
| R-HSA-525793 | Myogenesis | 0.093320 | 1.030 |
| R-HSA-3295583 | TRP channels | 0.093320 | 1.030 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.249816 | 0.602 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.034529 | 1.462 |
| R-HSA-392517 | Rap1 signalling | 0.318405 | 0.497 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.360624 | 0.443 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.124463 | 0.905 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.272137 | 0.565 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.307350 | 0.512 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.270117 | 0.568 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.353736 | 0.451 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.152408 | 0.817 |
| R-HSA-8939211 | ESR-mediated signaling | 0.229788 | 0.639 |
| R-HSA-199991 | Membrane Trafficking | 0.273528 | 0.563 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.229502 | 0.639 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.052833 | 1.277 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.124463 | 0.905 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.273410 | 0.563 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.083918 | 1.076 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.283014 | 0.548 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.096104 | 1.017 |
| R-HSA-1483166 | Synthesis of PA | 0.278018 | 0.556 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.270148 | 0.568 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.237734 | 0.624 |
| R-HSA-162582 | Signal Transduction | 0.175636 | 0.755 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.129974 | 0.886 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.074406 | 1.128 |
| R-HSA-4839726 | Chromatin organization | 0.030218 | 1.520 |
| R-HSA-74160 | Gene expression (Transcription) | 0.074455 | 1.128 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.140387 | 0.853 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.249816 | 0.602 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.283896 | 0.547 |
| R-HSA-201556 | Signaling by ALK | 0.167624 | 0.776 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.295637 | 0.529 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.150901 | 0.821 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.261707 | 0.582 |
| R-HSA-180292 | GAB1 signalosome | 0.307424 | 0.512 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.316960 | 0.499 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.194682 | 0.711 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.194682 | 0.711 |
| R-HSA-8853659 | RET signaling | 0.150901 | 0.821 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.258294 | 0.588 |
| R-HSA-212436 | Generic Transcription Pathway | 0.233502 | 0.632 |
| R-HSA-186712 | Regulation of beta-cell development | 0.289769 | 0.538 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.260940 | 0.583 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.174353 | 0.759 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.034196 | 1.466 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.318405 | 0.497 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.360624 | 0.443 |
| R-HSA-6807070 | PTEN Regulation | 0.239696 | 0.620 |
| R-HSA-446728 | Cell junction organization | 0.201463 | 0.696 |
| R-HSA-8983711 | OAS antiviral response | 0.225458 | 0.647 |
| R-HSA-1500931 | Cell-Cell communication | 0.171804 | 0.765 |
| R-HSA-418990 | Adherens junctions interactions | 0.331553 | 0.479 |
| R-HSA-450294 | MAP kinase activation | 0.099440 | 1.002 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.127201 | 0.896 |
| R-HSA-983712 | Ion channel transport | 0.240180 | 0.619 |
| R-HSA-448424 | Interleukin-17 signaling | 0.129974 | 0.886 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.123883 | 0.907 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.157714 | 0.802 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.356616 | 0.448 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.157480 | 0.803 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.222768 | 0.652 |
| R-HSA-177929 | Signaling by EGFR | 0.272137 | 0.565 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.215276 | 0.667 |
| R-HSA-75153 | Apoptotic execution phase | 0.213499 | 0.671 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.300290 | 0.522 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.253032 | 0.597 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.253032 | 0.597 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.253032 | 0.597 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.304619 | 0.516 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.308950 | 0.510 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.356616 | 0.448 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.308950 | 0.510 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.356616 | 0.448 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.287326 | 0.542 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.321955 | 0.492 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.334965 | 0.475 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.365174 | 0.438 |
| R-HSA-3371556 | Cellular response to heat stress | 0.365254 | 0.437 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.369567 | 0.432 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.369567 | 0.432 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.370765 | 0.431 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.370864 | 0.431 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.376535 | 0.424 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.380746 | 0.419 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.380746 | 0.419 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.380746 | 0.419 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.380746 | 0.419 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.382184 | 0.418 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.382184 | 0.418 |
| R-HSA-5689603 | UCH proteinases | 0.387811 | 0.411 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.388876 | 0.410 |
| R-HSA-9620244 | Long-term potentiation | 0.390569 | 0.408 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.390569 | 0.408 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.393416 | 0.405 |
| R-HSA-114608 | Platelet degranulation | 0.395315 | 0.403 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.398997 | 0.399 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.400237 | 0.398 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.400237 | 0.398 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.400237 | 0.398 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.400237 | 0.398 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.400237 | 0.398 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.400237 | 0.398 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.409752 | 0.387 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.409752 | 0.387 |
| R-HSA-264876 | Insulin processing | 0.409752 | 0.387 |
| R-HSA-201451 | Signaling by BMP | 0.409752 | 0.387 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.409752 | 0.387 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.410088 | 0.387 |
| R-HSA-9843745 | Adipogenesis | 0.416561 | 0.380 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.419117 | 0.378 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.419117 | 0.378 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.419117 | 0.378 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.421077 | 0.376 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.424994 | 0.372 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.428333 | 0.368 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.428333 | 0.368 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.428333 | 0.368 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.428333 | 0.368 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.432065 | 0.364 |
| R-HSA-421270 | Cell-cell junction organization | 0.434938 | 0.362 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.437364 | 0.359 |
| R-HSA-1500620 | Meiosis | 0.437364 | 0.359 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.437405 | 0.359 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.437405 | 0.359 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.437405 | 0.359 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.437405 | 0.359 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.437405 | 0.359 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.442737 | 0.354 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.442737 | 0.354 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.446332 | 0.350 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.446332 | 0.350 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.446332 | 0.350 |
| R-HSA-186763 | Downstream signal transduction | 0.446332 | 0.350 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.446332 | 0.350 |
| R-HSA-5688426 | Deubiquitination | 0.447335 | 0.349 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.448083 | 0.349 |
| R-HSA-9609690 | HCMV Early Events | 0.449114 | 0.348 |
| R-HSA-70268 | Pyruvate metabolism | 0.453399 | 0.344 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.453399 | 0.344 |
| R-HSA-1538133 | G0 and Early G1 | 0.455119 | 0.342 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.458686 | 0.338 |
| R-HSA-1632852 | Macroautophagy | 0.462383 | 0.335 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.463766 | 0.334 |
| R-HSA-9930044 | Nuclear RNA decay | 0.463766 | 0.334 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.463766 | 0.334 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.463766 | 0.334 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.463766 | 0.334 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.463766 | 0.334 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.463766 | 0.334 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.463766 | 0.334 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.469987 | 0.328 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.470552 | 0.327 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.470552 | 0.327 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.472277 | 0.326 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.472277 | 0.326 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.480654 | 0.318 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.480654 | 0.318 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.480654 | 0.318 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.480654 | 0.318 |
| R-HSA-392518 | Signal amplification | 0.480654 | 0.318 |
| R-HSA-391251 | Protein folding | 0.484670 | 0.315 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.488898 | 0.311 |
| R-HSA-187687 | Signalling to ERKs | 0.488898 | 0.311 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.494715 | 0.306 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.497011 | 0.304 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.497011 | 0.304 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.504997 | 0.297 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.504997 | 0.297 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.504997 | 0.297 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.505123 | 0.297 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.509871 | 0.293 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.510816 | 0.292 |
| R-HSA-8875878 | MET promotes cell motility | 0.512856 | 0.290 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.512856 | 0.290 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.518321 | 0.285 |
| R-HSA-73887 | Death Receptor Signaling | 0.518321 | 0.285 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.518321 | 0.285 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.519411 | 0.284 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.524600 | 0.280 |
| R-HSA-9612973 | Autophagy | 0.526058 | 0.279 |
| R-HSA-9646399 | Aggrephagy | 0.528203 | 0.277 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.528203 | 0.277 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.529444 | 0.276 |
| R-HSA-70171 | Glycolysis | 0.529444 | 0.276 |
| R-HSA-162587 | HIV Life Cycle | 0.529901 | 0.276 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.534254 | 0.272 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.535694 | 0.271 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.543068 | 0.265 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.543068 | 0.265 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.543068 | 0.265 |
| R-HSA-189451 | Heme biosynthesis | 0.543068 | 0.265 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.543068 | 0.265 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.553379 | 0.257 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.557467 | 0.254 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.557467 | 0.254 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.557467 | 0.254 |
| R-HSA-8854214 | TBC/RABGAPs | 0.557467 | 0.254 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.557467 | 0.254 |
| R-HSA-373752 | Netrin-1 signaling | 0.564496 | 0.248 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.564496 | 0.248 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.564496 | 0.248 |
| R-HSA-69236 | G1 Phase | 0.564496 | 0.248 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.564496 | 0.248 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.565536 | 0.248 |
| R-HSA-73894 | DNA Repair | 0.566680 | 0.247 |
| R-HSA-211000 | Gene Silencing by RNA | 0.566975 | 0.246 |
| R-HSA-5619102 | SLC transporter disorders | 0.567349 | 0.246 |
| R-HSA-774815 | Nucleosome assembly | 0.571413 | 0.243 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.571413 | 0.243 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.571413 | 0.243 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.571413 | 0.243 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.571413 | 0.243 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.571413 | 0.243 |
| R-HSA-195721 | Signaling by WNT | 0.574456 | 0.241 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.576016 | 0.240 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.578222 | 0.238 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.578222 | 0.238 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.581810 | 0.235 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.584922 | 0.233 |
| R-HSA-437239 | Recycling pathway of L1 | 0.584922 | 0.233 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.584922 | 0.233 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.589318 | 0.230 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.591517 | 0.228 |
| R-HSA-9634597 | GPER1 signaling | 0.591517 | 0.228 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.591517 | 0.228 |
| R-HSA-425410 | Metal ion SLC transporters | 0.591517 | 0.228 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.592454 | 0.227 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.593683 | 0.226 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.595963 | 0.225 |
| R-HSA-157118 | Signaling by NOTCH | 0.596944 | 0.224 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.598007 | 0.223 |
| R-HSA-9766229 | Degradation of CDH1 | 0.598007 | 0.223 |
| R-HSA-912446 | Meiotic recombination | 0.610681 | 0.214 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.610681 | 0.214 |
| R-HSA-8953854 | Metabolism of RNA | 0.612151 | 0.213 |
| R-HSA-72187 | mRNA 3'-end processing | 0.616867 | 0.210 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.616867 | 0.210 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.616867 | 0.210 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.619146 | 0.208 |
| R-HSA-70326 | Glucose metabolism | 0.619146 | 0.208 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.622956 | 0.206 |
| R-HSA-1221632 | Meiotic synapsis | 0.622956 | 0.206 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.622956 | 0.206 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.622956 | 0.206 |
| R-HSA-9609646 | HCMV Infection | 0.626472 | 0.203 |
| R-HSA-72649 | Translation initiation complex formation | 0.628949 | 0.201 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.634846 | 0.197 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.634846 | 0.197 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.635431 | 0.197 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.635431 | 0.197 |
| R-HSA-109582 | Hemostasis | 0.636133 | 0.196 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.640650 | 0.193 |
| R-HSA-8935690 | Digestion | 0.640650 | 0.193 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.640650 | 0.193 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.643002 | 0.192 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.643368 | 0.192 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.646363 | 0.190 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.646363 | 0.190 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.647285 | 0.189 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.651985 | 0.186 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.652566 | 0.185 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.661948 | 0.179 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.662756 | 0.179 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.662963 | 0.179 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.668322 | 0.175 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.668322 | 0.175 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.668322 | 0.175 |
| R-HSA-1268020 | Mitochondrial protein import | 0.673596 | 0.172 |
| R-HSA-186797 | Signaling by PDGF | 0.673596 | 0.172 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.673596 | 0.172 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.673596 | 0.172 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.673758 | 0.171 |
| R-HSA-1474165 | Reproduction | 0.677406 | 0.169 |
| R-HSA-6799198 | Complex I biogenesis | 0.678786 | 0.168 |
| R-HSA-8848021 | Signaling by PTK6 | 0.678786 | 0.168 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.678786 | 0.168 |
| R-HSA-8963743 | Digestion and absorption | 0.678786 | 0.168 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.678786 | 0.168 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.683895 | 0.165 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.683895 | 0.165 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.688922 | 0.162 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.688922 | 0.162 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.693870 | 0.159 |
| R-HSA-72172 | mRNA Splicing | 0.694774 | 0.158 |
| R-HSA-196807 | Nicotinate metabolism | 0.698739 | 0.156 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.703531 | 0.153 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.712889 | 0.147 |
| R-HSA-9664407 | Parasite infection | 0.715374 | 0.145 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.715374 | 0.145 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.715374 | 0.145 |
| R-HSA-189445 | Metabolism of porphyrins | 0.717457 | 0.144 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.721952 | 0.141 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.721952 | 0.141 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.726377 | 0.139 |
| R-HSA-68882 | Mitotic Anaphase | 0.727788 | 0.138 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.730410 | 0.136 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.730731 | 0.136 |
| R-HSA-917937 | Iron uptake and transport | 0.735016 | 0.134 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.737538 | 0.132 |
| R-HSA-8951664 | Neddylation | 0.740697 | 0.130 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.743384 | 0.129 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.749532 | 0.125 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.749532 | 0.125 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.751488 | 0.124 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.752457 | 0.124 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.755444 | 0.122 |
| R-HSA-6806834 | Signaling by MET | 0.755444 | 0.122 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.755444 | 0.122 |
| R-HSA-162906 | HIV Infection | 0.755544 | 0.122 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.757952 | 0.120 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.763862 | 0.117 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.766940 | 0.115 |
| R-HSA-72312 | rRNA processing | 0.767390 | 0.115 |
| R-HSA-9610379 | HCMV Late Events | 0.769393 | 0.114 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.770650 | 0.113 |
| R-HSA-913531 | Interferon Signaling | 0.773968 | 0.111 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.774303 | 0.111 |
| R-HSA-877300 | Interferon gamma signaling | 0.774811 | 0.111 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.777897 | 0.109 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.781434 | 0.107 |
| R-HSA-109581 | Apoptosis | 0.782730 | 0.106 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.784915 | 0.105 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.787874 | 0.104 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.795030 | 0.100 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.798296 | 0.098 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.800150 | 0.097 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.804672 | 0.094 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.804672 | 0.094 |
| R-HSA-72306 | tRNA processing | 0.805042 | 0.094 |
| R-HSA-2029481 | FCGR activation | 0.807784 | 0.093 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.810847 | 0.091 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.816828 | 0.088 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.819747 | 0.086 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.819747 | 0.086 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.819747 | 0.086 |
| R-HSA-611105 | Respiratory electron transport | 0.823146 | 0.085 |
| R-HSA-168255 | Influenza Infection | 0.825300 | 0.083 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.825447 | 0.083 |
| R-HSA-190236 | Signaling by FGFR | 0.825447 | 0.083 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.829337 | 0.081 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.833663 | 0.079 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.836315 | 0.078 |
| R-HSA-1483255 | PI Metabolism | 0.836315 | 0.078 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.836315 | 0.078 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.837088 | 0.077 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.838925 | 0.076 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.839467 | 0.076 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.841771 | 0.075 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.844021 | 0.074 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.844021 | 0.074 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.851235 | 0.070 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.853736 | 0.069 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.853736 | 0.069 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.856069 | 0.067 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.861822 | 0.065 |
| R-HSA-597592 | Post-translational protein modification | 0.862233 | 0.064 |
| R-HSA-166663 | Initial triggering of complement | 0.869310 | 0.061 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.870396 | 0.060 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.870396 | 0.060 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.871944 | 0.060 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.873448 | 0.059 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.873448 | 0.059 |
| R-HSA-1280218 | Adaptive Immune System | 0.874937 | 0.058 |
| R-HSA-5357801 | Programmed Cell Death | 0.875215 | 0.058 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.875468 | 0.058 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.875468 | 0.058 |
| R-HSA-373760 | L1CAM interactions | 0.875468 | 0.058 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.877455 | 0.057 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.879411 | 0.056 |
| R-HSA-1483257 | Phospholipid metabolism | 0.880094 | 0.055 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.881407 | 0.055 |
| R-HSA-73886 | Chromosome Maintenance | 0.885095 | 0.053 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.885825 | 0.053 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.887581 | 0.052 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.888735 | 0.051 |
| R-HSA-977606 | Regulation of Complement cascade | 0.892260 | 0.050 |
| R-HSA-449147 | Signaling by Interleukins | 0.893074 | 0.049 |
| R-HSA-194138 | Signaling by VEGF | 0.893981 | 0.049 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.893981 | 0.049 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-69206 | G1/S Transition | 0.893981 | 0.049 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.895572 | 0.048 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.895674 | 0.048 |
| R-HSA-9679506 | SARS-CoV Infections | 0.899734 | 0.046 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.905283 | 0.043 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.912347 | 0.040 |
| R-HSA-5368287 | Mitochondrial translation | 0.916737 | 0.038 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.916737 | 0.038 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.920666 | 0.036 |
| R-HSA-166658 | Complement cascade | 0.926810 | 0.033 |
| R-HSA-69242 | S Phase | 0.930266 | 0.031 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.933507 | 0.030 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.934623 | 0.029 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.935537 | 0.029 |
| R-HSA-9609507 | Protein localization | 0.935669 | 0.029 |
| R-HSA-1989781 | PPARA activates gene expression | 0.937711 | 0.028 |
| R-HSA-1266738 | Developmental Biology | 0.938465 | 0.028 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.939689 | 0.027 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.939689 | 0.027 |
| R-HSA-9711097 | Cellular response to starvation | 0.940655 | 0.027 |
| R-HSA-418555 | G alpha (s) signalling events | 0.952659 | 0.021 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.952659 | 0.021 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.953418 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 0.953819 | 0.021 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.953819 | 0.021 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.954164 | 0.020 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.954164 | 0.020 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.955621 | 0.020 |
| R-HSA-2559583 | Cellular Senescence | 0.959065 | 0.018 |
| R-HSA-3781865 | Diseases of glycosylation | 0.961628 | 0.017 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.963793 | 0.016 |
| R-HSA-9675108 | Nervous system development | 0.965246 | 0.015 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.970376 | 0.013 |
| R-HSA-428157 | Sphingolipid metabolism | 0.970852 | 0.013 |
| R-HSA-2262752 | Cellular responses to stress | 0.971605 | 0.013 |
| R-HSA-422475 | Axon guidance | 0.980803 | 0.008 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.981776 | 0.008 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.982069 | 0.008 |
| R-HSA-6798695 | Neutrophil degranulation | 0.982824 | 0.008 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.983993 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.985065 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 0.987033 | 0.006 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.991022 | 0.004 |
| R-HSA-382551 | Transport of small molecules | 0.991574 | 0.004 |
| R-HSA-168256 | Immune System | 0.992083 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992106 | 0.003 |
| R-HSA-72766 | Translation | 0.994243 | 0.003 |
| R-HSA-9824446 | Viral Infection Pathways | 0.995379 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.996048 | 0.002 |
| R-HSA-8957322 | Metabolism of steroids | 0.996111 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.996574 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.997976 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998699 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998895 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999291 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999635 | 0.000 |
| R-HSA-1643685 | Disease | 0.999763 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999805 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999970 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.864 | 0.781 | 1 | 0.859 |
CDK18 |
0.863 | 0.830 | 1 | 0.868 |
P38G |
0.862 | 0.861 | 1 | 0.900 |
KIS |
0.862 | 0.750 | 1 | 0.807 |
CDK19 |
0.860 | 0.805 | 1 | 0.857 |
CDK17 |
0.858 | 0.834 | 1 | 0.894 |
JNK2 |
0.858 | 0.868 | 1 | 0.868 |
CDK8 |
0.855 | 0.803 | 1 | 0.825 |
P38D |
0.854 | 0.840 | 1 | 0.898 |
CDK3 |
0.852 | 0.727 | 1 | 0.887 |
CDK16 |
0.852 | 0.801 | 1 | 0.882 |
CDK13 |
0.851 | 0.818 | 1 | 0.847 |
CDK7 |
0.851 | 0.795 | 1 | 0.828 |
DYRK2 |
0.850 | 0.762 | 1 | 0.780 |
CDK1 |
0.849 | 0.789 | 1 | 0.849 |
CDK12 |
0.849 | 0.817 | 1 | 0.866 |
ERK1 |
0.849 | 0.809 | 1 | 0.847 |
JNK3 |
0.847 | 0.850 | 1 | 0.840 |
P38B |
0.847 | 0.817 | 1 | 0.831 |
DYRK4 |
0.846 | 0.767 | 1 | 0.866 |
CDK5 |
0.844 | 0.776 | 1 | 0.801 |
CDK9 |
0.842 | 0.801 | 1 | 0.839 |
HIPK1 |
0.841 | 0.712 | 1 | 0.763 |
CDK10 |
0.841 | 0.756 | 1 | 0.851 |
HIPK4 |
0.840 | 0.533 | 1 | 0.579 |
CDK14 |
0.839 | 0.789 | 1 | 0.835 |
DYRK1B |
0.837 | 0.732 | 1 | 0.824 |
P38A |
0.837 | 0.790 | 1 | 0.771 |
CLK3 |
0.834 | 0.490 | 1 | 0.533 |
HIPK3 |
0.832 | 0.702 | 1 | 0.735 |
ERK2 |
0.830 | 0.791 | 1 | 0.802 |
CDK4 |
0.830 | 0.794 | 1 | 0.875 |
SRPK1 |
0.830 | 0.390 | -3 | 0.833 |
NLK |
0.830 | 0.726 | 1 | 0.578 |
DYRK1A |
0.829 | 0.630 | 1 | 0.742 |
CDK6 |
0.827 | 0.767 | 1 | 0.851 |
JNK1 |
0.827 | 0.758 | 1 | 0.863 |
CLK1 |
0.821 | 0.446 | -3 | 0.819 |
CLK2 |
0.820 | 0.436 | -3 | 0.826 |
CDK2 |
0.820 | 0.605 | 1 | 0.734 |
DYRK3 |
0.819 | 0.558 | 1 | 0.730 |
ERK5 |
0.818 | 0.407 | 1 | 0.481 |
SRPK2 |
0.817 | 0.317 | -3 | 0.764 |
CLK4 |
0.814 | 0.399 | -3 | 0.844 |
ICK |
0.809 | 0.378 | -3 | 0.905 |
MAK |
0.809 | 0.510 | -2 | 0.740 |
CDKL5 |
0.807 | 0.202 | -3 | 0.870 |
MTOR |
0.806 | 0.214 | 1 | 0.368 |
SRPK3 |
0.806 | 0.286 | -3 | 0.813 |
COT |
0.805 | -0.051 | 2 | 0.899 |
CDKL1 |
0.802 | 0.177 | -3 | 0.879 |
PRP4 |
0.801 | 0.479 | -3 | 0.827 |
MOK |
0.800 | 0.480 | 1 | 0.650 |
PRKD1 |
0.799 | 0.062 | -3 | 0.887 |
CDC7 |
0.795 | -0.087 | 1 | 0.196 |
MOS |
0.795 | 0.002 | 1 | 0.244 |
PRPK |
0.793 | -0.060 | -1 | 0.802 |
ERK7 |
0.792 | 0.302 | 2 | 0.617 |
PRKD2 |
0.792 | 0.054 | -3 | 0.834 |
TBK1 |
0.791 | -0.146 | 1 | 0.175 |
PIM3 |
0.790 | -0.018 | -3 | 0.899 |
PKN3 |
0.790 | -0.007 | -3 | 0.898 |
DSTYK |
0.790 | -0.101 | 2 | 0.907 |
ATR |
0.789 | -0.038 | 1 | 0.246 |
CAMK1B |
0.789 | -0.001 | -3 | 0.924 |
NEK6 |
0.788 | -0.053 | -2 | 0.799 |
GCN2 |
0.788 | -0.177 | 2 | 0.832 |
WNK1 |
0.788 | -0.041 | -2 | 0.838 |
CHAK2 |
0.788 | -0.032 | -1 | 0.808 |
IKKE |
0.787 | -0.153 | 1 | 0.175 |
ULK2 |
0.787 | -0.156 | 2 | 0.827 |
NDR2 |
0.786 | -0.038 | -3 | 0.888 |
NUAK2 |
0.785 | 0.029 | -3 | 0.901 |
RAF1 |
0.785 | -0.183 | 1 | 0.199 |
IKKB |
0.785 | -0.163 | -2 | 0.699 |
MAPKAPK3 |
0.785 | -0.002 | -3 | 0.848 |
MST4 |
0.784 | -0.050 | 2 | 0.863 |
NIK |
0.783 | -0.029 | -3 | 0.935 |
RSK2 |
0.783 | 0.009 | -3 | 0.841 |
BMPR2 |
0.783 | -0.163 | -2 | 0.823 |
SKMLCK |
0.783 | -0.027 | -2 | 0.811 |
P90RSK |
0.783 | 0.016 | -3 | 0.850 |
NDR1 |
0.783 | -0.049 | -3 | 0.892 |
PKN2 |
0.783 | -0.037 | -3 | 0.903 |
PIM1 |
0.782 | 0.036 | -3 | 0.854 |
PDHK4 |
0.782 | -0.188 | 1 | 0.260 |
TGFBR2 |
0.782 | -0.086 | -2 | 0.741 |
MAPKAPK2 |
0.782 | 0.012 | -3 | 0.805 |
PKCD |
0.782 | -0.016 | 2 | 0.821 |
CAMLCK |
0.781 | -0.006 | -2 | 0.783 |
RSK3 |
0.780 | -0.003 | -3 | 0.843 |
NEK7 |
0.780 | -0.156 | -3 | 0.883 |
PDHK1 |
0.780 | -0.171 | 1 | 0.244 |
ULK1 |
0.779 | -0.142 | -3 | 0.869 |
PRKD3 |
0.779 | 0.036 | -3 | 0.821 |
AURC |
0.779 | 0.005 | -2 | 0.584 |
RIPK3 |
0.779 | -0.133 | 3 | 0.742 |
P70S6KB |
0.779 | 0.002 | -3 | 0.868 |
IRE1 |
0.779 | -0.064 | 1 | 0.201 |
CAMK2G |
0.778 | -0.110 | 2 | 0.803 |
NEK9 |
0.777 | -0.123 | 2 | 0.880 |
DAPK2 |
0.777 | -0.029 | -3 | 0.927 |
PHKG1 |
0.777 | -0.028 | -3 | 0.890 |
MLK2 |
0.777 | -0.086 | 2 | 0.867 |
CAMK2D |
0.776 | -0.070 | -3 | 0.905 |
GRK1 |
0.776 | -0.041 | -2 | 0.727 |
AMPKA1 |
0.776 | -0.058 | -3 | 0.908 |
HUNK |
0.776 | -0.137 | 2 | 0.834 |
MLK1 |
0.775 | -0.150 | 2 | 0.842 |
MNK2 |
0.775 | -0.023 | -2 | 0.723 |
LATS2 |
0.774 | -0.052 | -5 | 0.732 |
PKCB |
0.774 | -0.011 | 2 | 0.780 |
MARK4 |
0.774 | -0.075 | 4 | 0.794 |
PINK1 |
0.774 | 0.178 | 1 | 0.413 |
IKKA |
0.774 | -0.108 | -2 | 0.698 |
MLK3 |
0.773 | -0.057 | 2 | 0.777 |
PKACG |
0.773 | -0.046 | -2 | 0.648 |
TSSK2 |
0.773 | -0.049 | -5 | 0.808 |
PAK6 |
0.773 | 0.002 | -2 | 0.638 |
BMPR1B |
0.773 | -0.038 | 1 | 0.164 |
AMPKA2 |
0.772 | -0.033 | -3 | 0.879 |
TSSK1 |
0.772 | -0.034 | -3 | 0.918 |
BCKDK |
0.772 | -0.161 | -1 | 0.711 |
PAK1 |
0.772 | -0.047 | -2 | 0.717 |
DNAPK |
0.772 | -0.038 | 1 | 0.232 |
PKCZ |
0.771 | -0.028 | 2 | 0.838 |
PAK3 |
0.771 | -0.067 | -2 | 0.715 |
PKCA |
0.771 | -0.015 | 2 | 0.768 |
GRK5 |
0.771 | -0.175 | -3 | 0.899 |
GSK3A |
0.770 | 0.194 | 4 | 0.465 |
ALK4 |
0.770 | -0.051 | -2 | 0.792 |
IRE2 |
0.770 | -0.071 | 2 | 0.769 |
PKR |
0.770 | -0.064 | 1 | 0.222 |
WNK3 |
0.770 | -0.216 | 1 | 0.199 |
NUAK1 |
0.770 | -0.022 | -3 | 0.856 |
MASTL |
0.770 | -0.181 | -2 | 0.749 |
AKT2 |
0.770 | 0.046 | -3 | 0.769 |
TGFBR1 |
0.770 | -0.043 | -2 | 0.773 |
ATM |
0.769 | -0.084 | 1 | 0.211 |
NEK2 |
0.769 | -0.084 | 2 | 0.867 |
DLK |
0.769 | -0.191 | 1 | 0.208 |
NIM1 |
0.769 | -0.092 | 3 | 0.751 |
MPSK1 |
0.769 | 0.054 | 1 | 0.272 |
MNK1 |
0.769 | -0.025 | -2 | 0.725 |
PKACB |
0.768 | 0.012 | -2 | 0.592 |
PKCG |
0.768 | -0.044 | 2 | 0.774 |
RIPK1 |
0.768 | -0.191 | 1 | 0.191 |
ANKRD3 |
0.768 | -0.170 | 1 | 0.216 |
VRK2 |
0.768 | 0.045 | 1 | 0.300 |
LATS1 |
0.768 | -0.017 | -3 | 0.893 |
TTBK2 |
0.768 | -0.172 | 2 | 0.765 |
CHAK1 |
0.768 | -0.109 | 2 | 0.852 |
GRK7 |
0.767 | -0.028 | 1 | 0.212 |
MELK |
0.767 | -0.059 | -3 | 0.869 |
SMG1 |
0.767 | -0.066 | 1 | 0.231 |
SGK3 |
0.767 | 0.003 | -3 | 0.834 |
RSK4 |
0.766 | -0.000 | -3 | 0.807 |
GRK6 |
0.766 | -0.147 | 1 | 0.188 |
MSK2 |
0.765 | -0.036 | -3 | 0.827 |
YSK4 |
0.765 | -0.143 | 1 | 0.184 |
CAMK2A |
0.765 | -0.026 | 2 | 0.784 |
CAMK4 |
0.764 | -0.117 | -3 | 0.882 |
PIM2 |
0.764 | 0.031 | -3 | 0.823 |
QSK |
0.764 | -0.042 | 4 | 0.766 |
MAPKAPK5 |
0.764 | -0.044 | -3 | 0.816 |
PKCH |
0.763 | -0.059 | 2 | 0.759 |
AURB |
0.763 | -0.034 | -2 | 0.575 |
CAMK2B |
0.763 | -0.067 | 2 | 0.772 |
PKG2 |
0.763 | -0.026 | -2 | 0.590 |
MLK4 |
0.762 | -0.107 | 2 | 0.767 |
QIK |
0.761 | -0.107 | -3 | 0.895 |
PLK1 |
0.760 | -0.161 | -2 | 0.723 |
TLK2 |
0.760 | -0.124 | 1 | 0.197 |
MSK1 |
0.760 | -0.025 | -3 | 0.832 |
SIK |
0.760 | -0.042 | -3 | 0.839 |
ACVR2B |
0.760 | -0.092 | -2 | 0.748 |
MEK1 |
0.760 | -0.142 | 2 | 0.869 |
PRKX |
0.759 | 0.018 | -3 | 0.743 |
DCAMKL1 |
0.759 | -0.031 | -3 | 0.850 |
MST3 |
0.759 | -0.041 | 2 | 0.869 |
BRSK2 |
0.758 | -0.087 | -3 | 0.880 |
CAMK1G |
0.758 | -0.039 | -3 | 0.843 |
IRAK4 |
0.758 | -0.103 | 1 | 0.181 |
AKT1 |
0.758 | 0.015 | -3 | 0.783 |
PAK2 |
0.758 | -0.095 | -2 | 0.695 |
PKCT |
0.758 | -0.043 | 2 | 0.774 |
PHKG2 |
0.758 | -0.058 | -3 | 0.862 |
GRK4 |
0.758 | -0.197 | -2 | 0.756 |
MYLK4 |
0.757 | -0.045 | -2 | 0.702 |
WNK4 |
0.757 | -0.101 | -2 | 0.831 |
NEK5 |
0.757 | -0.094 | 1 | 0.195 |
ACVR2A |
0.757 | -0.107 | -2 | 0.734 |
BRSK1 |
0.757 | -0.061 | -3 | 0.864 |
ALK2 |
0.757 | -0.085 | -2 | 0.775 |
MEKK1 |
0.756 | -0.131 | 1 | 0.213 |
PERK |
0.756 | -0.142 | -2 | 0.779 |
LKB1 |
0.756 | 0.022 | -3 | 0.886 |
PKCI |
0.756 | -0.017 | 2 | 0.797 |
CHK1 |
0.756 | -0.064 | -3 | 0.871 |
FAM20C |
0.756 | -0.052 | 2 | 0.573 |
GSK3B |
0.756 | 0.051 | 4 | 0.457 |
HRI |
0.755 | -0.155 | -2 | 0.784 |
ZAK |
0.755 | -0.151 | 1 | 0.194 |
MEK5 |
0.755 | -0.147 | 2 | 0.860 |
MARK3 |
0.754 | -0.059 | 4 | 0.720 |
MEKK2 |
0.754 | -0.111 | 2 | 0.845 |
DRAK1 |
0.754 | -0.146 | 1 | 0.158 |
BRAF |
0.754 | -0.115 | -4 | 0.827 |
TAO3 |
0.753 | -0.057 | 1 | 0.231 |
PLK4 |
0.753 | -0.152 | 2 | 0.654 |
PAK5 |
0.753 | -0.040 | -2 | 0.564 |
P70S6K |
0.753 | -0.019 | -3 | 0.792 |
BUB1 |
0.752 | 0.057 | -5 | 0.790 |
SSTK |
0.752 | -0.049 | 4 | 0.749 |
TLK1 |
0.751 | -0.137 | -2 | 0.778 |
DCAMKL2 |
0.751 | -0.048 | -3 | 0.869 |
SNRK |
0.751 | -0.154 | 2 | 0.708 |
AURA |
0.751 | -0.055 | -2 | 0.549 |
PKN1 |
0.751 | -0.005 | -3 | 0.806 |
BMPR1A |
0.751 | -0.073 | 1 | 0.154 |
PKACA |
0.751 | -0.005 | -2 | 0.545 |
GRK2 |
0.751 | -0.105 | -2 | 0.656 |
MARK2 |
0.750 | -0.078 | 4 | 0.682 |
MEKK3 |
0.750 | -0.180 | 1 | 0.206 |
PKCE |
0.750 | -0.001 | 2 | 0.756 |
PAK4 |
0.750 | -0.030 | -2 | 0.572 |
CK1E |
0.750 | -0.026 | -3 | 0.582 |
PLK3 |
0.749 | -0.155 | 2 | 0.776 |
PASK |
0.749 | -0.052 | -3 | 0.906 |
SMMLCK |
0.749 | -0.040 | -3 | 0.889 |
SBK |
0.748 | 0.137 | -3 | 0.654 |
AKT3 |
0.748 | 0.029 | -3 | 0.709 |
PDK1 |
0.747 | -0.053 | 1 | 0.231 |
HGK |
0.747 | -0.041 | 3 | 0.873 |
MEKK6 |
0.747 | -0.066 | 1 | 0.203 |
TAO2 |
0.747 | -0.058 | 2 | 0.877 |
NEK4 |
0.747 | -0.100 | 1 | 0.190 |
NEK11 |
0.747 | -0.129 | 1 | 0.224 |
GAK |
0.747 | -0.048 | 1 | 0.247 |
TNIK |
0.747 | -0.018 | 3 | 0.872 |
MAP3K15 |
0.746 | -0.077 | 1 | 0.205 |
HASPIN |
0.746 | 0.035 | -1 | 0.661 |
NEK8 |
0.745 | -0.146 | 2 | 0.850 |
CAMKK1 |
0.745 | -0.140 | -2 | 0.731 |
GCK |
0.744 | -0.076 | 1 | 0.212 |
MARK1 |
0.744 | -0.104 | 4 | 0.737 |
KHS1 |
0.744 | -0.017 | 1 | 0.208 |
CAMKK2 |
0.744 | -0.099 | -2 | 0.729 |
SGK1 |
0.743 | 0.042 | -3 | 0.694 |
MINK |
0.743 | -0.090 | 1 | 0.190 |
CAMK1D |
0.743 | -0.024 | -3 | 0.761 |
CHK2 |
0.743 | 0.013 | -3 | 0.720 |
HPK1 |
0.743 | -0.057 | 1 | 0.214 |
PBK |
0.743 | -0.023 | 1 | 0.223 |
LOK |
0.742 | -0.060 | -2 | 0.688 |
LRRK2 |
0.741 | -0.017 | 2 | 0.881 |
NEK1 |
0.741 | -0.090 | 1 | 0.180 |
CK1D |
0.741 | -0.007 | -3 | 0.533 |
EEF2K |
0.741 | -0.055 | 3 | 0.832 |
KHS2 |
0.740 | -0.007 | 1 | 0.221 |
TTBK1 |
0.740 | -0.169 | 2 | 0.670 |
DAPK3 |
0.740 | -0.039 | -3 | 0.870 |
CK1G1 |
0.739 | -0.068 | -3 | 0.580 |
CAMK1A |
0.739 | 0.003 | -3 | 0.737 |
MRCKB |
0.738 | -0.009 | -3 | 0.814 |
MST2 |
0.738 | -0.135 | 1 | 0.195 |
CK2A2 |
0.737 | -0.079 | 1 | 0.142 |
IRAK1 |
0.737 | -0.216 | -1 | 0.693 |
SLK |
0.736 | -0.076 | -2 | 0.628 |
ROCK2 |
0.735 | -0.017 | -3 | 0.854 |
CK1A2 |
0.735 | -0.032 | -3 | 0.534 |
YSK1 |
0.734 | -0.093 | 2 | 0.852 |
TAK1 |
0.734 | -0.169 | 1 | 0.190 |
NEK3 |
0.733 | -0.083 | 1 | 0.206 |
STK33 |
0.733 | -0.121 | 2 | 0.653 |
VRK1 |
0.733 | -0.156 | 2 | 0.868 |
MRCKA |
0.732 | -0.035 | -3 | 0.827 |
GRK3 |
0.732 | -0.113 | -2 | 0.615 |
DAPK1 |
0.732 | -0.049 | -3 | 0.857 |
PDHK3_TYR |
0.732 | 0.132 | 4 | 0.872 |
DMPK1 |
0.732 | 0.020 | -3 | 0.827 |
MST1 |
0.731 | -0.143 | 1 | 0.188 |
BIKE |
0.731 | -0.019 | 1 | 0.233 |
CK2A1 |
0.728 | -0.088 | 1 | 0.133 |
LIMK2_TYR |
0.727 | 0.134 | -3 | 0.931 |
AAK1 |
0.727 | 0.015 | 1 | 0.234 |
CRIK |
0.727 | 0.015 | -3 | 0.777 |
PKG1 |
0.726 | -0.044 | -2 | 0.513 |
RIPK2 |
0.726 | -0.212 | 1 | 0.181 |
TESK1_TYR |
0.725 | 0.045 | 3 | 0.860 |
OSR1 |
0.725 | -0.073 | 2 | 0.852 |
MYO3B |
0.724 | -0.046 | 2 | 0.862 |
MEK2 |
0.724 | -0.194 | 2 | 0.853 |
ROCK1 |
0.724 | -0.024 | -3 | 0.828 |
PKMYT1_TYR |
0.722 | 0.095 | 3 | 0.830 |
ASK1 |
0.722 | -0.106 | 1 | 0.203 |
PLK2 |
0.722 | -0.107 | -3 | 0.816 |
TTK |
0.722 | -0.085 | -2 | 0.748 |
TAO1 |
0.721 | -0.079 | 1 | 0.203 |
PDHK4_TYR |
0.721 | 0.023 | 2 | 0.887 |
MAP2K4_TYR |
0.720 | 0.007 | -1 | 0.810 |
MAP2K6_TYR |
0.719 | 0.008 | -1 | 0.828 |
MYO3A |
0.717 | -0.088 | 1 | 0.214 |
BMPR2_TYR |
0.717 | 0.016 | -1 | 0.829 |
MAP2K7_TYR |
0.717 | -0.100 | 2 | 0.872 |
PINK1_TYR |
0.716 | -0.109 | 1 | 0.250 |
PDHK1_TYR |
0.715 | -0.051 | -1 | 0.840 |
RET |
0.714 | -0.117 | 1 | 0.221 |
TNNI3K_TYR |
0.712 | 0.015 | 1 | 0.240 |
LIMK1_TYR |
0.712 | -0.016 | 2 | 0.880 |
MST1R |
0.712 | -0.078 | 3 | 0.810 |
CSF1R |
0.712 | -0.061 | 3 | 0.800 |
NEK10_TYR |
0.711 | -0.069 | 1 | 0.197 |
EPHA6 |
0.711 | -0.063 | -1 | 0.817 |
JAK2 |
0.711 | -0.087 | 1 | 0.226 |
ALPHAK3 |
0.711 | -0.108 | -1 | 0.737 |
TYK2 |
0.710 | -0.158 | 1 | 0.208 |
JAK1 |
0.708 | -0.049 | 1 | 0.198 |
JAK3 |
0.708 | -0.092 | 1 | 0.207 |
ROS1 |
0.707 | -0.113 | 3 | 0.772 |
ABL2 |
0.707 | -0.081 | -1 | 0.747 |
EPHB4 |
0.706 | -0.109 | -1 | 0.771 |
YANK3 |
0.705 | -0.068 | 2 | 0.420 |
STLK3 |
0.704 | -0.168 | 1 | 0.183 |
TYRO3 |
0.704 | -0.156 | 3 | 0.800 |
ABL1 |
0.703 | -0.086 | -1 | 0.734 |
FGFR2 |
0.702 | -0.054 | 3 | 0.778 |
TNK2 |
0.702 | -0.091 | 3 | 0.756 |
LCK |
0.702 | -0.063 | -1 | 0.790 |
TXK |
0.702 | -0.085 | 1 | 0.159 |
TNK1 |
0.702 | -0.069 | 3 | 0.777 |
FGR |
0.701 | -0.147 | 1 | 0.177 |
KDR |
0.701 | -0.073 | 3 | 0.763 |
BLK |
0.701 | -0.051 | -1 | 0.794 |
FGFR1 |
0.701 | -0.047 | 3 | 0.757 |
CK1A |
0.700 | -0.053 | -3 | 0.439 |
YES1 |
0.699 | -0.116 | -1 | 0.771 |
DDR1 |
0.699 | -0.151 | 4 | 0.770 |
KIT |
0.699 | -0.114 | 3 | 0.797 |
HCK |
0.699 | -0.117 | -1 | 0.777 |
INSRR |
0.697 | -0.141 | 3 | 0.734 |
TEK |
0.697 | -0.038 | 3 | 0.731 |
PDGFRB |
0.696 | -0.186 | 3 | 0.804 |
FLT3 |
0.696 | -0.162 | 3 | 0.806 |
MET |
0.695 | -0.098 | 3 | 0.787 |
ITK |
0.695 | -0.141 | -1 | 0.741 |
EPHA4 |
0.693 | -0.102 | 2 | 0.764 |
PDGFRA |
0.692 | -0.188 | 3 | 0.805 |
EPHB1 |
0.692 | -0.175 | 1 | 0.166 |
WEE1_TYR |
0.692 | -0.084 | -1 | 0.680 |
FER |
0.692 | -0.209 | 1 | 0.182 |
SRMS |
0.692 | -0.182 | 1 | 0.161 |
AXL |
0.691 | -0.165 | 3 | 0.777 |
EPHB3 |
0.691 | -0.162 | -1 | 0.757 |
FGFR3 |
0.690 | -0.076 | 3 | 0.749 |
FYN |
0.689 | -0.078 | -1 | 0.774 |
EPHB2 |
0.689 | -0.153 | -1 | 0.752 |
BMX |
0.689 | -0.119 | -1 | 0.669 |
MERTK |
0.689 | -0.154 | 3 | 0.775 |
DDR2 |
0.689 | -0.055 | 3 | 0.720 |
FLT1 |
0.688 | -0.127 | -1 | 0.793 |
FRK |
0.688 | -0.125 | -1 | 0.792 |
ERBB2 |
0.687 | -0.152 | 1 | 0.184 |
TEC |
0.685 | -0.162 | -1 | 0.661 |
FLT4 |
0.685 | -0.149 | 3 | 0.742 |
EPHA1 |
0.685 | -0.143 | 3 | 0.778 |
ALK |
0.685 | -0.167 | 3 | 0.707 |
EGFR |
0.685 | -0.103 | 1 | 0.153 |
EPHA7 |
0.684 | -0.132 | 2 | 0.779 |
BTK |
0.682 | -0.224 | -1 | 0.691 |
NTRK3 |
0.682 | -0.148 | -1 | 0.700 |
LTK |
0.681 | -0.183 | 3 | 0.727 |
NTRK1 |
0.681 | -0.220 | -1 | 0.739 |
INSR |
0.681 | -0.168 | 3 | 0.712 |
EPHA3 |
0.681 | -0.147 | 2 | 0.745 |
NTRK2 |
0.680 | -0.210 | 3 | 0.752 |
MUSK |
0.680 | -0.119 | 1 | 0.141 |
PTK2B |
0.680 | -0.116 | -1 | 0.700 |
LYN |
0.680 | -0.141 | 3 | 0.717 |
PTK6 |
0.679 | -0.221 | -1 | 0.661 |
MATK |
0.678 | -0.115 | -1 | 0.680 |
SRC |
0.678 | -0.122 | -1 | 0.750 |
EPHA8 |
0.678 | -0.115 | -1 | 0.761 |
PTK2 |
0.677 | -0.049 | -1 | 0.773 |
FGFR4 |
0.676 | -0.112 | -1 | 0.708 |
SYK |
0.675 | -0.078 | -1 | 0.764 |
CSK |
0.674 | -0.154 | 2 | 0.779 |
EPHA5 |
0.673 | -0.158 | 2 | 0.750 |
ERBB4 |
0.673 | -0.084 | 1 | 0.151 |
CK1G3 |
0.672 | -0.074 | -3 | 0.393 |
YANK2 |
0.670 | -0.091 | 2 | 0.433 |
EPHA2 |
0.667 | -0.131 | -1 | 0.725 |
ZAP70 |
0.664 | -0.056 | -1 | 0.685 |
IGF1R |
0.663 | -0.161 | 3 | 0.647 |
CK1G2 |
0.659 | -0.068 | -3 | 0.493 |
FES |
0.647 | -0.171 | -1 | 0.636 |