Motif 25 (n=248)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S519 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A1XBS5 | CIBAR1 | S243 | ochoa | CBY1-interacting BAR domain-containing protein 1 | Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (PubMed:30404948). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (PubMed:30404948). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (PubMed:30404948). Plays a crucial role in ciliogenesis (PubMed:27528616, PubMed:30395363). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity). {ECO:0000250|UniProtKB:Q8BP22, ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363, ECO:0000269|PubMed:30404948}. |
| A2RRP1 | NBAS | S1384 | ochoa | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}. |
| A6NMK8 | INSYN2B | S100 | ochoa | Protein INSYN2B (Inhibitory synaptic factor family member 2B) | None |
| D6RIA3 | C4orf54 | S1423 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| E7ENX8 | None | S455 | ochoa | ABC-type antigen peptide transporter (EC 7.4.2.14) | None |
| E7EWF7 | None | S93 | ochoa | Uncharacterized protein | None |
| O00159 | MYO1C | S408 | ochoa | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}. |
| O00167 | EYA2 | S260 | ochoa | Protein phosphatase EYA2 (EC 3.1.3.48) (Eyes absent homolog 2) | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}. |
| O00311 | CDC7 | S302 | ochoa | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O14607 | UTY | S716 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O14795 | UNC13B | S912 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O14901 | KLF11 | S124 | ochoa|psp | Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) | Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}. |
| O14901 | KLF11 | S260 | ochoa | Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) | Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}. |
| O15014 | ZNF609 | S1313 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15014 | ZNF609 | S1357 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15018 | PDZD2 | S850 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15062 | ZBTB5 | S234 | ochoa | Zinc finger and BTB domain-containing protein 5 | May be involved in transcriptional regulation. |
| O15075 | DCLK1 | S32 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15417 | TNRC18 | S1540 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15550 | KDM6A | S769 | ochoa | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}. |
| O43379 | WDR62 | S445 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43426 | SYNJ1 | S1318 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43602 | DCX | S28 | ochoa|psp | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| O43829 | ZBTB14 | S190 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O60237 | PPP1R12B | S855 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60293 | ZFC3H1 | S655 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60336 | MAPKBP1 | S488 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60496 | DOK2 | S77 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| O60890 | OPHN1 | S372 | ochoa | Oligophrenin-1 | Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}. |
| O75446 | SAP30 | S138 | ochoa | Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30) | Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| O75970 | MPDZ | S1194 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O76094 | SRP72 | S443 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94782 | USP1 | S327 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94818 | NOL4 | S248 | ochoa | Nucleolar protein 4 (Nucleolar-localized protein) | None |
| O94885 | SASH1 | S442 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94901 | SUN1 | S48 | psp | SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}. |
| O94927 | HAUS5 | S71 | ochoa | HAUS augmin-like complex subunit 5 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| O95453 | PARN | S101 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95835 | LATS1 | S635 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P04350 | TUBB4A | S172 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05023 | ATP1A1 | S228 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05496 | ATP5MC1 | S32 | ochoa | ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 1) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c) (Proton-conducting channel, ATP synthase F(0) complex subunit c) | Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix (PubMed:37244256). Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism (PubMed:37244256). {ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P06401 | PGR | S676 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P07437 | TUBB | S172 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08151 | GLI1 | S201 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P10071 | GLI3 | S445 | ochoa | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10275 | AR | S310 | ochoa|psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P11137 | MAP2 | S338 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P13164 | IFITM1 | S80 | ochoa | Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}. |
| P13639 | EEF2 | S502 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P15822 | HIVEP1 | S1051 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17861 | XBP1 | S181 | psp | X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] | Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}. |
| P18754 | RCC1 | S387 | psp | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:3678831}. |
| P20916 | MAG | S545 | ochoa | Myelin-associated glycoprotein (Siglec-4a) | Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). {ECO:0000250|UniProtKB:P07722, ECO:0000250|UniProtKB:P20917}. |
| P27694 | RPA1 | S38 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P31629 | HIVEP2 | S412 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P31937 | HIBADH | S88 | ochoa | 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) | None |
| P35251 | RFC1 | S312 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35968 | KDR | S229 | psp | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| P41235 | HNF4A | S378 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42858 | HTT | S118 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43405 | SYK | S350 | ochoa | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P43694 | GATA4 | S417 | ochoa | Transcription factor GATA-4 (GATA-binding factor 4) | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735). {ECO:0000250|UniProtKB:P46152, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15734735, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169, ECO:0000269|PubMed:27984724, ECO:0000269|PubMed:35182466}. |
| P45985 | MAP2K4 | S90 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46937 | YAP1 | S340 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P48745 | CCN3 | S316 | ochoa | CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH) | Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:12050162, PubMed:12695522, PubMed:15181016, PubMed:15611078, PubMed:21344378). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:15611078, PubMed:21344378). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). Brain osteoanabolic hormone (By similarity). Drives osteogenesis in osteochondral skeletal stem cells (PubMed:38987585). During lactation, maintains the maternal skeleton and viability of offspring (By similarity). {ECO:0000250|UniProtKB:Q64299, ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12695522, ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:15611078, ECO:0000269|PubMed:17463287, ECO:0000269|PubMed:20139355, ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:21344378, ECO:0000269|PubMed:21871891, ECO:0000269|PubMed:38987585}. |
| P52294 | KPNA1 | S95 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P52333 | JAK3 | S493 | ochoa | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P53794 | SLC5A3 | S591 | ochoa | Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}. |
| P54278 | PMS2 | S220 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P61221 | ABCE1 | S547 | ochoa | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| P68371 | TUBB4B | S172 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78524 | DENND2B | S539 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78527 | PRKDC | S2547 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P98082 | DAB2 | S401 | ochoa|psp | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q03188 | CENPC | S158 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q03519 | TAP2 | S455 | ochoa | Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11) | ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25377891, PubMed:25656091). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed:25377891). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (PubMed:11274390, PubMed:25377891, PubMed:25656091). Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect (PubMed:11274390, PubMed:7500034, PubMed:9256420). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (PubMed:1538751, PubMed:25377891, PubMed:26611325). {ECO:0000269|PubMed:11274390, ECO:0000269|PubMed:1538751, ECO:0000269|PubMed:25377891, ECO:0000269|PubMed:25656091, ECO:0000269|PubMed:26611325, ECO:0000269|PubMed:7500034, ECO:0000269|PubMed:9256420}. |
| Q04726 | TLE3 | S521 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q06710 | PAX8 | S251 | ochoa | Paired box protein Pax-8 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| Q0JRZ9 | FCHO2 | S387 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12879 | GRIN2A | S882 | ochoa | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q12986 | NFX1 | S326 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13023 | AKAP6 | S1644 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13144 | EIF2B5 | S610 | ochoa | Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
| Q13228 | SELENBP1 | S53 | ochoa | Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}. |
| Q13237 | PRKG2 | S97 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13370 | PDE3B | S514 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13415 | ORC1 | S610 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13480 | GAB1 | S381 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13509 | TUBB3 | S172 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S172 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14183 | DOC2A | S221 | ochoa | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}. |
| Q14203 | DCTN1 | S1180 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14207 | NPAT | S207 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14207 | NPAT | S1100 | ochoa|psp | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14315 | FLNC | S566 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1962 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14324 | MYBPC2 | S167 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14669 | TRIP12 | S1427 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14865 | ARID5B | S1133 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q15020 | SART3 | S778 | ochoa | Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}. |
| Q15648 | MED1 | S1401 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16649 | NFIL3 | S210 | ochoa | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}. |
| Q16799 | RTN1 | S480 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q16831 | UPP1 | S61 | ochoa | Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) | Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:7488099). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable). {ECO:0000269|PubMed:7488099, ECO:0000305|PubMed:13737038}. |
| Q17R98 | ZNF827 | S760 | ochoa | Zinc finger protein 827 | As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance (PubMed:25150861). {ECO:0000269|PubMed:25150861, ECO:0000269|PubMed:33174841}. |
| Q2KHR3 | QSER1 | S759 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q2M2Z5 | KIZ | S276 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q2TAK8 | PWWP3A | S129 | ochoa | PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}. |
| Q52LW3 | ARHGAP29 | S1029 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q562E7 | WDR81 | S1272 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5JWR5 | DOP1A | S2421 | ochoa | Protein DOP1A | May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}. |
| Q5T0T0 | MARCHF8 | S253 | ochoa | E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) | E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:34285233, PubMed:35019698). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Also blocks ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation (PubMed:39311660). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897, ECO:0000269|PubMed:28320822, ECO:0000269|PubMed:32934085, ECO:0000269|PubMed:34183449, ECO:0000269|PubMed:34285233, ECO:0000269|PubMed:35019698, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:39311660}.; FUNCTION: (Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment. {ECO:0000269|PubMed:30759391}. |
| Q5T3J3 | LRIF1 | S451 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5TCX8 | MAP3K21 | S618 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5TGL8 | PXDC1 | S150 | ochoa | PX domain-containing protein 1 | None |
| Q5TH69 | ARFGEF3 | S1676 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5VT06 | CEP350 | S258 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT25 | CDC42BPA | S364 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VZ89 | DENND4C | S703 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q6P4F7 | ARHGAP11A | S422 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P996 | PDXDC1 | S79 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6P9H4 | CNKSR3 | S244 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6PJG6 | BRAT1 | S798 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6PJQ5 | FOXR2 | S139 | ochoa | Forkhead box protein R2 (Forkhead box protein N6) | None |
| Q6PJT7 | ZC3H14 | S620 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6PJW8 | CNST | S336 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6PJW8 | CNST | S348 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6TFL4 | KLHL24 | S19 | ochoa | Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) | Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (PubMed:30715372). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062, ECO:0000269|PubMed:30715372}. |
| Q6UB98 | ANKRD12 | S543 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6XQN6 | NAPRT | S513 | ochoa | Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}. |
| Q6ZU65 | UBN2 | S941 | ochoa | Ubinuclein-2 | None |
| Q702N8 | XIRP1 | S481 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q70E73 | RAPH1 | S1154 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7L5N1 | COPS6 | S148 | psp | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}. |
| Q7RTV5 | PRXL2C | S143 | ochoa | Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1) | May positively regulate ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. {ECO:0000269|PubMed:29901208}. |
| Q7Z2D5 | PLPPR4 | S592 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z2Z1 | TICRR | S1057 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z5L2 | R3HCC1L | S688 | ochoa | Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like) | None |
| Q7Z6J9 | TSEN54 | S178 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q86UR5 | RIMS1 | S731 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86VP1 | TAX1BP1 | S609 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86XI6 | PPP1R3B | S261 | ochoa | Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). {ECO:0000250}. |
| Q86YC2 | PALB2 | S660 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IW41 | MAPKAPK5 | S212 | ochoa | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IWU2 | LMTK2 | S630 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IXJ9 | ASXL1 | S1166 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8IXZ2 | ZC3H3 | S593 | ochoa | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). {ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. |
| Q8IYB4 | PEX5L | S447 | ochoa | PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Peroxisome biogenesis factor 5-like) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b) | Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. {ECO:0000250|UniProtKB:Q8C437}. |
| Q8IZT6 | ASPM | S367 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N2G6 | ZCCHC24 | S93 | ochoa | Zinc finger CCHC domain-containing protein 24 | None |
| Q8N5U6 | RNF10 | S128 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
| Q8N7B6 | PACRGL | S47 | ochoa | PACRG-like protein | None |
| Q8N8V4 | ANKS4B | S283 | ochoa | Ankyrin repeat and SAM domain-containing protein 4B (Harmonin-interacting ankyrin repeat-containing protein) (Harp) | As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}. |
| Q8ND24 | RNF214 | S154 | ochoa | RING finger protein 214 | None |
| Q8ND56 | LSM14A | S124 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDV7 | TNRC6A | S739 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NFU7 | TET1 | S871 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8NG08 | HELB | S1058 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8WUY3 | PRUNE2 | S576 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVR3 | TRAPPC14 | S546 | ochoa | Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) | Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:30715179, PubMed:31467083). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. |
| Q8WWI1 | LMO7 | S1450 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXI2 | CNKSR2 | S248 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q8WYA6 | CTNNBL1 | S545 | ochoa | Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19) | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies (PubMed:32484799). {ECO:0000269|PubMed:32484799}. |
| Q92503 | SEC14L1 | S586 | ochoa | SEC14-like protein 1 | May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}. |
| Q92610 | ZNF592 | S1052 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92628 | KIAA0232 | S712 | ochoa | Uncharacterized protein KIAA0232 | None |
| Q92664 | GTF3A | S347 | ochoa | Transcription factor IIIA (TFIIIA) | Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}. |
| Q96BY7 | ATG2B | S735 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96C24 | SYTL4 | S488 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96CF2 | CHMP4C | S21 | ochoa | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}. |
| Q96DR7 | ARHGEF26 | S329 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96EY5 | MVB12A | S232 | ochoa|psp | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96F86 | EDC3 | S131 | ochoa|psp | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96FG2 | ELMOD3 | S27 | ochoa | ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29) | Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. {ECO:0000269|PubMed:24039609}. |
| Q96GE4 | CEP95 | S353 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96MU7 | YTHDC1 | S424 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96Q42 | ALS2 | S1335 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96S38 | RPS6KC1 | S282 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S38 | RPS6KC1 | S423 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99569 | PKP4 | S675 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99618 | CDCA3 | S222 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99728 | BARD1 | S251 | psp | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q99728 | BARD1 | S330 | ochoa | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q99741 | CDC6 | S106 | ochoa|psp | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BPX3 | NCAPG | S844 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BQF6 | SENP7 | S46 | ochoa | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}. |
| Q9BQI7 | PSD2 | S220 | ochoa | PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) | None |
| Q9BSJ5 | MTNAP1 | S231 | ochoa | Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) | Critical regulator of mitochondrial DNA (mtDNA) abundance (PubMed:37676315). Binds dsDNA throughout the mitochondrial genome without sequence specificity and controls mtDNA copy number by promoting its replication (PubMed:37676315). Also plays important roles in mitochondrial metabolism and cell proliferation (PubMed:37676315). {ECO:0000269|PubMed:37676315}. |
| Q9BUF5 | TUBB6 | S172 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | S172 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BX40 | LSM14B | S154 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BXL7 | CARD11 | S925 | ochoa|psp | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BY89 | KIAA1671 | S1786 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H079 | KATNBL1 | S89 | ochoa | KATNB1-like protein 1 (Katanin p80 subunit B-like 1) | Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}. |
| Q9H0H3 | KLHL25 | S285 | ochoa | Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}. |
| Q9H211 | CDT1 | S491 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H223 | EHD4 | S157 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H2I8 | LRMDA | S153 | ochoa | Leucine-rich melanocyte differentiation-associated protein | Required for melanocyte differentiation. {ECO:0000269|PubMed:23395477}. |
| Q9H329 | EPB41L4B | S254 | ochoa | Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) | Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}. |
| Q9H5U6 | ZCCHC4 | S381 | ochoa | rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4) | rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31695039, PubMed:31799605). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605). {ECO:0000269|PubMed:30531910, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31695039, ECO:0000269|PubMed:31799605}. |
| Q9H773 | DCTPP1 | S85 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H8K7 | PAAT | S177 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9H9E1 | ANKRA2 | S124 | ochoa | Ankyrin repeat family A protein 2 (RFXANK-like protein 2) | May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}. |
| Q9HAJ7 | SAP30L | S99 | ochoa | Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) | [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}. |
| Q9HAU0 | PLEKHA5 | S526 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HAW0 | BRF2 | S186 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
| Q9HCI5 | MAGEE1 | S467 | ochoa | Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| Q9NPB8 | GPCPD1 | S175 | ochoa | Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) | May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. {ECO:0000250}. |
| Q9NQX0 | PRDM6 | S456 | ochoa | Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6) | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. {ECO:0000250|UniProtKB:Q3UZD5}. |
| Q9NRG9 | AAAS | S33 | ochoa | Aladin (Adracalin) | Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). {ECO:0000269|PubMed:11062474, ECO:0000269|PubMed:11159947, ECO:0000269|PubMed:16022285, ECO:0000269|PubMed:26246606}. |
| Q9NS62 | THSD1 | S456 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
| Q9NX01 | TXNL4B | S96 | ochoa | Thioredoxin-like protein 4B (Dim1-like protein) | Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}. |
| Q9P1Z3 | HCN3 | S562 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity). {ECO:0000250|UniProtKB:O88705, ECO:0000269|PubMed:16043489}. |
| Q9P227 | ARHGAP23 | S843 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2F6 | ARHGAP20 | S1113 | ochoa | Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2K3 | RCOR3 | S234 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9UBB9 | TFIP11 | S283 | ochoa | Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
| Q9UGU0 | TCF20 | S1335 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UJV8 | PURG | S156 | ochoa | Purine-rich element-binding protein gamma (Purine-rich element-binding protein G) | None |
| Q9UK80 | USP21 | S538 | psp | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
| Q9ULJ7 | ANKRD50 | S1111 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9ULM3 | YEATS2 | S1043 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULT8 | HECTD1 | S710 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9UMD9 | COL17A1 | S150 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UPP1 | PHF8 | S593 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPU5 | USP24 | S914 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW8 | UNC13A | S988 | ochoa | Protein unc-13 homolog A (Munc13-1) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q4KUS2, ECO:0000250|UniProtKB:Q62768, ECO:0000269|PubMed:23999003}. |
| Q9UQ80 | PA2G4 | S90 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y272 | RASD1 | S202 | ochoa | Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1) | Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). {ECO:0000250}. |
| Q9Y2H2 | INPP5F | S1103 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y2L6 | FRMD4B | S915 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y4B5 | MTCL1 | S1561 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y566 | SHANK1 | S413 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Q9Y597 | KCTD3 | S711 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5X3 | SNX5 | S60 | ochoa | Sorting nexin-5 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}. |
| Q9Y6D6 | ARFGEF1 | S410 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6N9 | USH1C | S201 | ochoa | Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018}. |
| Q9Y6X8 | ZHX2 | S628 | ochoa | Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}. |
| Q9BQQ3 | GORASP1 | S373 | SIGNOR | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| P30281 | CCND3 | S133 | Sugiyama | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| Q02641 | CACNB1 | S161 | SIGNOR | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q04721 | NOTCH2 | S671 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q9Y3D2 | MSRB2 | S95 | Sugiyama | Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14) | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}. |
| P43629 | KIR3DL1 | S296 | iPTMNet | Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e) | Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:22020283}. |
| Q969H0 | FBXW7 | S372 | GPS6 | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17434132, PubMed:22748924, PubMed:26976582, PubMed:28727686, PubMed:34741373, PubMed:35395208). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:17434132, PubMed:22748924, PubMed:26774286, PubMed:26976582, PubMed:28727686, PubMed:34741373). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 (PubMed:11565034, PubMed:11585921, PubMed:12354302, PubMed:14739463, PubMed:15103331, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:25775507, PubMed:25897075, PubMed:26976582, PubMed:28007894, PubMed:28727686, PubMed:29149593, PubMed:34102342). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (PubMed:26774286). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (PubMed:26774286). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:35395208, ECO:0000305|PubMed:12354302}. |
| Q9NR20 | DYRK4 | S501 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) | Possible non-essential role in spermiogenesis. {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.817046e-08 | 7.235 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.364733e-08 | 7.360 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.112267e-07 | 6.675 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.839157e-07 | 6.547 |
| R-HSA-1640170 | Cell Cycle | 5.952190e-07 | 6.225 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.744556e-06 | 5.758 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.068745e-06 | 5.391 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.697344e-06 | 5.432 |
| R-HSA-190828 | Gap junction trafficking | 6.246731e-06 | 5.204 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.252039e-06 | 5.204 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 7.834058e-06 | 5.106 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.204681e-05 | 4.919 |
| R-HSA-190861 | Gap junction assembly | 1.231138e-05 | 4.910 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.436208e-05 | 4.843 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.796744e-05 | 4.746 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.169045e-05 | 4.664 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.444179e-05 | 4.612 |
| R-HSA-9646399 | Aggrephagy | 2.920916e-05 | 4.534 |
| R-HSA-68886 | M Phase | 5.987424e-05 | 4.223 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 6.869183e-05 | 4.163 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 7.765052e-05 | 4.110 |
| R-HSA-437239 | Recycling pathway of L1 | 7.765052e-05 | 4.110 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.380895e-04 | 3.860 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.546273e-04 | 3.811 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.764405e-04 | 3.753 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.306534e-04 | 3.637 |
| R-HSA-983189 | Kinesins | 2.811173e-04 | 3.551 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.340119e-04 | 3.476 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 4.523416e-04 | 3.345 |
| R-HSA-69275 | G2/M Transition | 4.384944e-04 | 3.358 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.264114e-04 | 3.370 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.773157e-04 | 3.321 |
| R-HSA-68962 | Activation of the pre-replicative complex | 5.612720e-04 | 3.251 |
| R-HSA-68877 | Mitotic Prometaphase | 5.872370e-04 | 3.231 |
| R-HSA-5620924 | Intraflagellar transport | 6.207005e-04 | 3.207 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.790866e-04 | 3.168 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.573030e-04 | 3.067 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.209542e-03 | 2.917 |
| R-HSA-9833482 | PKR-mediated signaling | 1.260413e-03 | 2.899 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.359345e-03 | 2.867 |
| R-HSA-9612973 | Autophagy | 1.479012e-03 | 2.830 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.728514e-03 | 2.762 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.848971e-03 | 2.733 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.052825e-03 | 2.688 |
| R-HSA-9663891 | Selective autophagy | 2.174095e-03 | 2.663 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.350932e-03 | 2.629 |
| R-HSA-3214842 | HDMs demethylate histones | 2.625661e-03 | 2.581 |
| R-HSA-1632852 | Macroautophagy | 2.666968e-03 | 2.574 |
| R-HSA-391251 | Protein folding | 2.865629e-03 | 2.543 |
| R-HSA-373760 | L1CAM interactions | 2.859524e-03 | 2.544 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.399634e-03 | 2.469 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.535790e-03 | 2.452 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.582554e-03 | 2.446 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.131787e-03 | 2.384 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.033506e-03 | 2.394 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.908484e-03 | 2.408 |
| R-HSA-68882 | Mitotic Anaphase | 4.336346e-03 | 2.363 |
| R-HSA-69206 | G1/S Transition | 4.439783e-03 | 2.353 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.472297e-03 | 2.349 |
| R-HSA-5617833 | Cilium Assembly | 5.360825e-03 | 2.271 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 5.490186e-03 | 2.260 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 5.490186e-03 | 2.260 |
| R-HSA-199991 | Membrane Trafficking | 5.741642e-03 | 2.241 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.879615e-03 | 2.231 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.141678e-03 | 2.146 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 9.531107e-03 | 2.021 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.007301e-02 | 1.997 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.007301e-02 | 1.997 |
| R-HSA-9758920 | Formation of lateral plate mesoderm | 9.531107e-03 | 2.021 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 1.101723e-02 | 1.958 |
| R-HSA-9609646 | HCMV Infection | 1.121261e-02 | 1.950 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.186507e-02 | 1.926 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.686099e-02 | 1.773 |
| R-HSA-9675135 | Diseases of DNA repair | 1.753983e-02 | 1.756 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.782795e-02 | 1.749 |
| R-HSA-380287 | Centrosome maturation | 1.850992e-02 | 1.733 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.913354e-02 | 1.718 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.972688e-02 | 1.705 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.076537e-02 | 1.683 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.117701e-02 | 1.674 |
| R-HSA-8949613 | Cristae formation | 2.281582e-02 | 1.642 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 2.372373e-02 | 1.625 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.413299e-02 | 1.617 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.414423e-02 | 1.617 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.462980e-02 | 1.609 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.495544e-02 | 1.603 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.651939e-02 | 1.576 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.651939e-02 | 1.576 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 2.660965e-02 | 1.575 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.719208e-02 | 1.566 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.052475e-02 | 1.515 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 3.085082e-02 | 1.511 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.263998e-02 | 1.486 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.561895e-02 | 1.448 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 3.561895e-02 | 1.448 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 3.561895e-02 | 1.448 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.561895e-02 | 1.448 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.821323e-02 | 1.418 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.557199e-02 | 1.449 |
| R-HSA-69306 | DNA Replication | 3.799023e-02 | 1.420 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.709369e-02 | 1.431 |
| R-HSA-9930044 | Nuclear RNA decay | 3.482977e-02 | 1.458 |
| R-HSA-186712 | Regulation of beta-cell development | 3.474850e-02 | 1.459 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 3.870807e-02 | 1.412 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.943126e-02 | 1.404 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.943126e-02 | 1.404 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 4.289141e-02 | 1.368 |
| R-HSA-9609690 | HCMV Early Events | 4.418294e-02 | 1.355 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.432506e-02 | 1.353 |
| R-HSA-110312 | Translesion synthesis by REV1 | 4.723480e-02 | 1.326 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.890493e-02 | 1.311 |
| R-HSA-9830369 | Kidney development | 4.890493e-02 | 1.311 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.938235e-02 | 1.306 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.950615e-02 | 1.305 |
| R-HSA-5656121 | Translesion synthesis by POLI | 5.173117e-02 | 1.286 |
| R-HSA-5655862 | Translesion synthesis by POLK | 5.637368e-02 | 1.249 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.287271e-02 | 1.277 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.780359e-02 | 1.238 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.496874e-02 | 1.260 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 6.115565e-02 | 1.214 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 6.115565e-02 | 1.214 |
| R-HSA-2028269 | Signaling by Hippo | 6.115565e-02 | 1.214 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.302366e-02 | 1.200 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 6.607062e-02 | 1.180 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 7.111230e-02 | 1.148 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 7.627458e-02 | 1.118 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.627458e-02 | 1.118 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 7.627458e-02 | 1.118 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 7.627458e-02 | 1.118 |
| R-HSA-110320 | Translesion Synthesis by POLH | 7.111230e-02 | 1.148 |
| R-HSA-5358508 | Mismatch Repair | 6.607062e-02 | 1.180 |
| R-HSA-69239 | Synthesis of DNA | 6.730365e-02 | 1.172 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 6.997339e-02 | 1.155 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 6.607062e-02 | 1.180 |
| R-HSA-9823730 | Formation of definitive endoderm | 7.627458e-02 | 1.118 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 7.620572e-02 | 1.118 |
| R-HSA-112316 | Neuronal System | 6.434721e-02 | 1.191 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 7.627458e-02 | 1.118 |
| R-HSA-9831926 | Nephron development | 6.607062e-02 | 1.180 |
| R-HSA-913531 | Interferon Signaling | 6.695804e-02 | 1.174 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 6.607062e-02 | 1.180 |
| R-HSA-1280218 | Adaptive Immune System | 7.829691e-02 | 1.106 |
| R-HSA-8865999 | MET activates PTPN11 | 8.669046e-02 | 1.062 |
| R-HSA-1296061 | HCN channels | 1.031080e-01 | 0.987 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 1.031080e-01 | 0.987 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 1.031080e-01 | 0.987 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.192315e-01 | 0.924 |
| R-HSA-109703 | PKB-mediated events | 1.350661e-01 | 0.869 |
| R-HSA-165160 | PDE3B signalling | 1.350661e-01 | 0.869 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.506170e-01 | 0.822 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.506170e-01 | 0.822 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.658892e-01 | 0.780 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.658892e-01 | 0.780 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.658892e-01 | 0.780 |
| R-HSA-8875656 | MET receptor recycling | 1.808877e-01 | 0.743 |
| R-HSA-196025 | Formation of annular gap junctions | 1.808877e-01 | 0.743 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.808877e-01 | 0.743 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.808877e-01 | 0.743 |
| R-HSA-190873 | Gap junction degradation | 1.956175e-01 | 0.709 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.100832e-01 | 0.678 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 8.693740e-02 | 1.061 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 2.242897e-01 | 0.649 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 2.242897e-01 | 0.649 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.382416e-01 | 0.623 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 2.382416e-01 | 0.623 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.094608e-01 | 0.961 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.519433e-01 | 0.599 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 2.653994e-01 | 0.576 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.333085e-01 | 0.875 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.915923e-01 | 0.535 |
| R-HSA-68949 | Orc1 removal from chromatin | 9.683820e-02 | 1.014 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.709296e-01 | 0.767 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.903405e-01 | 0.720 |
| R-HSA-180292 | GAB1 signalosome | 3.412184e-01 | 0.467 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.166344e-01 | 0.664 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 3.530738e-01 | 0.452 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.530738e-01 | 0.452 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.647165e-01 | 0.438 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.647165e-01 | 0.438 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.984066e-01 | 0.400 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.984066e-01 | 0.400 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.032877e-01 | 0.518 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.485516e-01 | 0.605 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.231782e-01 | 0.491 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 1.979680e-01 | 0.703 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.761504e-01 | 0.425 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.830280e-01 | 0.737 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.333085e-01 | 0.875 |
| R-HSA-73893 | DNA Damage Bypass | 8.625763e-02 | 1.064 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.166344e-01 | 0.664 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.808877e-01 | 0.743 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.653994e-01 | 0.576 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.519433e-01 | 0.599 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.956175e-01 | 0.709 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.873792e-01 | 0.412 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.699389e-01 | 0.569 |
| R-HSA-69091 | Polymerase switching | 2.519433e-01 | 0.599 |
| R-HSA-69109 | Leading Strand Synthesis | 2.519433e-01 | 0.599 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.653994e-01 | 0.576 |
| R-HSA-418457 | cGMP effects | 2.786143e-01 | 0.555 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.786143e-01 | 0.555 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.291466e-01 | 0.483 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 3.984066e-01 | 0.400 |
| R-HSA-451927 | Interleukin-2 family signaling | 2.100261e-01 | 0.678 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.581866e-01 | 0.801 |
| R-HSA-4641265 | Repression of WNT target genes | 2.519433e-01 | 0.599 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.363601e-01 | 0.473 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.153107e-01 | 0.938 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 1.192315e-01 | 0.924 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.786143e-01 | 0.555 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.581866e-01 | 0.801 |
| R-HSA-5576893 | Phase 2 - plateau phase | 3.168543e-01 | 0.499 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.299032e-01 | 0.638 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.761504e-01 | 0.425 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.346368e-01 | 0.475 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.192208e-01 | 0.924 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.969974e-01 | 0.706 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.456594e-01 | 0.837 |
| R-HSA-8985947 | Interleukin-9 signaling | 1.808877e-01 | 0.743 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 1.394422e-01 | 0.856 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.645360e-01 | 0.784 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 8.669046e-02 | 1.062 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 2.100832e-01 | 0.678 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.581866e-01 | 0.801 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.519433e-01 | 0.599 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 2.166344e-01 | 0.664 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.740740e-01 | 0.759 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.873792e-01 | 0.412 |
| R-HSA-69186 | Lagging Strand Synthesis | 8.155153e-02 | 1.089 |
| R-HSA-5693538 | Homology Directed Repair | 2.194154e-01 | 0.659 |
| R-HSA-9733709 | Cardiogenesis | 1.581866e-01 | 0.801 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.933321e-01 | 0.714 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.808877e-01 | 0.743 |
| R-HSA-429947 | Deadenylation of mRNA | 1.036935e-01 | 0.984 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.519433e-01 | 0.599 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.653994e-01 | 0.576 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 2.653994e-01 | 0.576 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.709296e-01 | 0.767 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.100261e-01 | 0.678 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.984066e-01 | 0.400 |
| R-HSA-109704 | PI3K Cascade | 2.832970e-01 | 0.548 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.838353e-01 | 0.736 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 9.060069e-02 | 1.043 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.921020e-01 | 0.716 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.838353e-01 | 0.736 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.740740e-01 | 0.759 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.332675e-02 | 1.030 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.094500e-01 | 0.509 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.563144e-01 | 0.448 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.915923e-01 | 0.535 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.709296e-01 | 0.767 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.291466e-01 | 0.483 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.530738e-01 | 0.452 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.966329e-01 | 0.528 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 9.242660e-02 | 1.034 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.786143e-01 | 0.555 |
| R-HSA-69190 | DNA strand elongation | 1.518852e-01 | 0.818 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.341721e-01 | 0.630 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.165621e-01 | 0.500 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.102587e-01 | 0.958 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.956175e-01 | 0.709 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.412184e-01 | 0.467 |
| R-HSA-69481 | G2/M Checkpoints | 1.181717e-01 | 0.927 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.855759e-01 | 0.544 |
| R-HSA-73894 | DNA Repair | 1.561046e-01 | 0.807 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 8.669046e-02 | 1.062 |
| R-HSA-429593 | Inositol transporters | 1.192315e-01 | 0.924 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 1.350661e-01 | 0.869 |
| R-HSA-1483152 | Hydrolysis of LPE | 1.506170e-01 | 0.822 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 8.155153e-02 | 1.089 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 1.036935e-01 | 0.984 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.168543e-01 | 0.499 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.168543e-01 | 0.499 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.034390e-01 | 0.692 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.232610e-01 | 0.651 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.761504e-01 | 0.425 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.152508e-01 | 0.667 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.753447e-01 | 0.756 |
| R-HSA-112399 | IRS-mediated signalling | 3.297780e-01 | 0.482 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.464867e-01 | 0.460 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.153107e-01 | 0.938 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.100261e-01 | 0.678 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.429229e-01 | 0.465 |
| R-HSA-157118 | Signaling by NOTCH | 1.959553e-01 | 0.708 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.234072e-01 | 0.909 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.968761e-01 | 0.706 |
| R-HSA-68875 | Mitotic Prophase | 9.880957e-02 | 1.005 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.581866e-01 | 0.801 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.773639e-01 | 0.751 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.624818e-01 | 0.441 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.081185e-01 | 0.682 |
| R-HSA-69242 | S Phase | 1.855721e-01 | 0.731 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.498968e-01 | 0.602 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 1.031080e-01 | 0.987 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 1.350661e-01 | 0.869 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.100832e-01 | 0.678 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 1.153107e-01 | 0.938 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2.034390e-01 | 0.692 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 3.530738e-01 | 0.452 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.873792e-01 | 0.412 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.559851e-01 | 0.449 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.945720e-01 | 0.404 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.299032e-01 | 0.638 |
| R-HSA-180786 | Extension of Telomeres | 3.429229e-01 | 0.465 |
| R-HSA-9610379 | HCMV Late Events | 3.917461e-01 | 0.407 |
| R-HSA-8853659 | RET signaling | 1.838353e-01 | 0.736 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.913002e-01 | 0.407 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.658892e-01 | 0.780 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.786143e-01 | 0.555 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.915923e-01 | 0.535 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.915923e-01 | 0.535 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.043376e-01 | 0.517 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.412184e-01 | 0.467 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.761504e-01 | 0.425 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.366455e-01 | 0.473 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.437426e-01 | 0.613 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 3.291466e-01 | 0.483 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.474535e-01 | 0.831 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.624818e-01 | 0.441 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.754000e-01 | 0.426 |
| R-HSA-5578768 | Physiological factors | 2.786143e-01 | 0.555 |
| R-HSA-1483115 | Hydrolysis of LPC | 2.786143e-01 | 0.555 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 8.625763e-02 | 1.064 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.291466e-01 | 0.483 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.291466e-01 | 0.483 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.100261e-01 | 0.678 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.818191e-01 | 0.418 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.385921e-01 | 0.622 |
| R-HSA-447043 | Neurofascin interactions | 1.506170e-01 | 0.822 |
| R-HSA-5676934 | Protein repair | 2.915923e-01 | 0.535 |
| R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... | 3.168543e-01 | 0.499 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.009036e-01 | 0.397 |
| R-HSA-5688426 | Deubiquitination | 3.816720e-01 | 0.418 |
| R-HSA-2262752 | Cellular responses to stress | 1.891744e-01 | 0.723 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.760086e-02 | 1.057 |
| R-HSA-8983711 | OAS antiviral response | 2.519433e-01 | 0.599 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.773639e-01 | 0.751 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.620187e-01 | 0.790 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.002208e-01 | 0.398 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.761504e-01 | 0.425 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.761504e-01 | 0.425 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.658892e-01 | 0.780 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.786143e-01 | 0.555 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.873792e-01 | 0.412 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.231782e-01 | 0.491 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.754000e-01 | 0.426 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.761504e-01 | 0.425 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.102587e-01 | 0.958 |
| R-HSA-9758941 | Gastrulation | 1.886439e-01 | 0.724 |
| R-HSA-8876725 | Protein methylation | 2.915923e-01 | 0.535 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.761504e-01 | 0.425 |
| R-HSA-9830364 | Formation of the nephric duct | 1.094608e-01 | 0.961 |
| R-HSA-75893 | TNF signaling | 3.231782e-01 | 0.491 |
| R-HSA-73884 | Base Excision Repair | 2.679219e-01 | 0.572 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.915923e-01 | 0.535 |
| R-HSA-210991 | Basigin interactions | 3.761504e-01 | 0.425 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.875506e-01 | 0.727 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.812693e-01 | 0.742 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 3.530738e-01 | 0.452 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.675441e-01 | 0.776 |
| R-HSA-73887 | Death Receptor Signaling | 3.795321e-01 | 0.421 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.873792e-01 | 0.412 |
| R-HSA-1483255 | PI Metabolism | 3.366455e-01 | 0.473 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 1.153107e-01 | 0.938 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.875506e-01 | 0.727 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.966811e-01 | 0.706 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.485516e-01 | 0.605 |
| R-HSA-4839726 | Chromatin organization | 2.188272e-01 | 0.660 |
| R-HSA-162906 | HIV Infection | 2.927796e-01 | 0.533 |
| R-HSA-1538133 | G0 and Early G1 | 1.518852e-01 | 0.818 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.565753e-01 | 0.591 |
| R-HSA-162592 | Integration of provirus | 2.382416e-01 | 0.623 |
| R-HSA-210993 | Tie2 Signaling | 3.412184e-01 | 0.467 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.984066e-01 | 0.400 |
| R-HSA-162587 | HIV Life Cycle | 1.012677e-01 | 0.995 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.034390e-01 | 0.692 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.156312e-01 | 0.666 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 3.530738e-01 | 0.452 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.494651e-01 | 0.457 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 3.291466e-01 | 0.483 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.494651e-01 | 0.457 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.494651e-01 | 0.457 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.494651e-01 | 0.457 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.494651e-01 | 0.457 |
| R-HSA-9675108 | Nervous system development | 2.090255e-01 | 0.680 |
| R-HSA-5620971 | Pyroptosis | 1.272391e-01 | 0.895 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.966329e-01 | 0.528 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 9.242660e-02 | 1.034 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.761504e-01 | 0.425 |
| R-HSA-5218859 | Regulated Necrosis | 4.009036e-01 | 0.397 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.363601e-01 | 0.473 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.092361e-01 | 0.388 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.092361e-01 | 0.388 |
| R-HSA-8854691 | Interleukin-20 family signaling | 4.092361e-01 | 0.388 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.121199e-01 | 0.385 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.197077e-01 | 0.377 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.197077e-01 | 0.377 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.242681e-01 | 0.372 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.259092e-01 | 0.371 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.259092e-01 | 0.371 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.303158e-01 | 0.366 |
| R-HSA-9839394 | TGFBR3 expression | 4.303158e-01 | 0.366 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.303158e-01 | 0.366 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.303158e-01 | 0.366 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.303158e-01 | 0.366 |
| R-HSA-9620244 | Long-term potentiation | 4.303158e-01 | 0.366 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.303158e-01 | 0.366 |
| R-HSA-4086398 | Ca2+ pathway | 4.320761e-01 | 0.364 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.337962e-01 | 0.363 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.382076e-01 | 0.358 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 4.405728e-01 | 0.356 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.405728e-01 | 0.356 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.405728e-01 | 0.356 |
| R-HSA-70635 | Urea cycle | 4.405728e-01 | 0.356 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.405728e-01 | 0.356 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 4.405728e-01 | 0.356 |
| R-HSA-73886 | Chromosome Maintenance | 4.432663e-01 | 0.353 |
| R-HSA-8951664 | Neddylation | 4.436140e-01 | 0.353 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.443031e-01 | 0.352 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.503260e-01 | 0.346 |
| R-HSA-5689603 | UCH proteinases | 4.503617e-01 | 0.346 |
| R-HSA-422475 | Axon guidance | 4.504602e-01 | 0.346 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.506458e-01 | 0.346 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.506458e-01 | 0.346 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.506458e-01 | 0.346 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.506458e-01 | 0.346 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.506458e-01 | 0.346 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.573541e-01 | 0.340 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.600133e-01 | 0.337 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.605380e-01 | 0.337 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.605380e-01 | 0.337 |
| R-HSA-73614 | Pyrimidine salvage | 4.605380e-01 | 0.337 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.623660e-01 | 0.335 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 4.683105e-01 | 0.329 |
| R-HSA-9659379 | Sensory processing of sound | 4.683105e-01 | 0.329 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.702526e-01 | 0.328 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.702526e-01 | 0.328 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.702526e-01 | 0.328 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.702526e-01 | 0.328 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.702526e-01 | 0.328 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.702526e-01 | 0.328 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.715358e-01 | 0.326 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.797930e-01 | 0.319 |
| R-HSA-2424491 | DAP12 signaling | 4.797930e-01 | 0.319 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.797930e-01 | 0.319 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.797930e-01 | 0.319 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.797930e-01 | 0.319 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.797930e-01 | 0.319 |
| R-HSA-112311 | Neurotransmitter clearance | 4.797930e-01 | 0.319 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.797930e-01 | 0.319 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.797930e-01 | 0.319 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.800815e-01 | 0.319 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.891621e-01 | 0.311 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.891621e-01 | 0.311 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.891621e-01 | 0.311 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.983630e-01 | 0.302 |
| R-HSA-5576891 | Cardiac conduction | 4.986633e-01 | 0.302 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.988863e-01 | 0.302 |
| R-HSA-8939211 | ESR-mediated signaling | 4.990068e-01 | 0.302 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.031379e-01 | 0.298 |
| R-HSA-1500620 | Meiosis | 5.031379e-01 | 0.298 |
| R-HSA-1266738 | Developmental Biology | 5.042671e-01 | 0.297 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.073987e-01 | 0.295 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.073987e-01 | 0.295 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 5.073987e-01 | 0.295 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.073987e-01 | 0.295 |
| R-HSA-354192 | Integrin signaling | 5.073987e-01 | 0.295 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.073987e-01 | 0.295 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.073987e-01 | 0.295 |
| R-HSA-390522 | Striated Muscle Contraction | 5.162723e-01 | 0.287 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.162723e-01 | 0.287 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.162723e-01 | 0.287 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.162723e-01 | 0.287 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.162723e-01 | 0.287 |
| R-HSA-1980145 | Signaling by NOTCH2 | 5.249865e-01 | 0.280 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.249865e-01 | 0.280 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.249865e-01 | 0.280 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.249865e-01 | 0.280 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.335443e-01 | 0.273 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.335443e-01 | 0.273 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.335443e-01 | 0.273 |
| R-HSA-2559585 | Oncogene Induced Senescence | 5.335443e-01 | 0.273 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.335443e-01 | 0.273 |
| R-HSA-381042 | PERK regulates gene expression | 5.335443e-01 | 0.273 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.364626e-01 | 0.270 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.419484e-01 | 0.266 |
| R-HSA-3371511 | HSF1 activation | 5.419484e-01 | 0.266 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 5.502016e-01 | 0.259 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.502016e-01 | 0.259 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.502016e-01 | 0.259 |
| R-HSA-419037 | NCAM1 interactions | 5.502016e-01 | 0.259 |
| R-HSA-8948216 | Collagen chain trimerization | 5.502016e-01 | 0.259 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.502016e-01 | 0.259 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.525411e-01 | 0.258 |
| R-HSA-8875878 | MET promotes cell motility | 5.583066e-01 | 0.253 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.662661e-01 | 0.247 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.662661e-01 | 0.247 |
| R-HSA-201556 | Signaling by ALK | 5.662661e-01 | 0.247 |
| R-HSA-9648002 | RAS processing | 5.662661e-01 | 0.247 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.740826e-01 | 0.241 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.740826e-01 | 0.241 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.784565e-01 | 0.238 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.784565e-01 | 0.238 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.817587e-01 | 0.235 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.817587e-01 | 0.235 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.817587e-01 | 0.235 |
| R-HSA-9607240 | FLT3 Signaling | 5.817587e-01 | 0.235 |
| R-HSA-157579 | Telomere Maintenance | 5.835062e-01 | 0.234 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.892969e-01 | 0.230 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.892969e-01 | 0.230 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.892969e-01 | 0.230 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 5.892969e-01 | 0.230 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.892969e-01 | 0.230 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.892969e-01 | 0.230 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.934718e-01 | 0.227 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.966997e-01 | 0.224 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.966997e-01 | 0.224 |
| R-HSA-73928 | Depyrimidination | 5.966997e-01 | 0.224 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.966997e-01 | 0.224 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.039696e-01 | 0.219 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.039696e-01 | 0.219 |
| R-HSA-73621 | Pyrimidine catabolism | 6.039696e-01 | 0.219 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.042110e-01 | 0.219 |
| R-HSA-9824446 | Viral Infection Pathways | 6.061879e-01 | 0.217 |
| R-HSA-397014 | Muscle contraction | 6.074957e-01 | 0.216 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.080854e-01 | 0.216 |
| R-HSA-69236 | G1 Phase | 6.111088e-01 | 0.214 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.111088e-01 | 0.214 |
| R-HSA-2172127 | DAP12 interactions | 6.111088e-01 | 0.214 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.176048e-01 | 0.209 |
| R-HSA-774815 | Nucleosome assembly | 6.181198e-01 | 0.209 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.181198e-01 | 0.209 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.181198e-01 | 0.209 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.181198e-01 | 0.209 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.181198e-01 | 0.209 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.196811e-01 | 0.208 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.250048e-01 | 0.204 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.250048e-01 | 0.204 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.250048e-01 | 0.204 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.250048e-01 | 0.204 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.250048e-01 | 0.204 |
| R-HSA-9839373 | Signaling by TGFBR3 | 6.250048e-01 | 0.204 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.250048e-01 | 0.204 |
| R-HSA-75153 | Apoptotic execution phase | 6.250048e-01 | 0.204 |
| R-HSA-5633007 | Regulation of TP53 Activity | 6.272612e-01 | 0.203 |
| R-HSA-211000 | Gene Silencing by RNA | 6.361097e-01 | 0.196 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.361097e-01 | 0.196 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.361097e-01 | 0.196 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.513296e-01 | 0.186 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.576178e-01 | 0.182 |
| R-HSA-912446 | Meiotic recombination | 6.576178e-01 | 0.182 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 6.576178e-01 | 0.182 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.582477e-01 | 0.182 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.582477e-01 | 0.182 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.637929e-01 | 0.178 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.637929e-01 | 0.178 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.637929e-01 | 0.178 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.698571e-01 | 0.174 |
| R-HSA-1221632 | Meiotic synapsis | 6.698571e-01 | 0.174 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.758123e-01 | 0.170 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.758123e-01 | 0.170 |
| R-HSA-177929 | Signaling by EGFR | 6.874033e-01 | 0.163 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.874033e-01 | 0.163 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.874033e-01 | 0.163 |
| R-HSA-5578775 | Ion homeostasis | 6.874033e-01 | 0.163 |
| R-HSA-5621480 | Dectin-2 family | 6.930430e-01 | 0.159 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.930430e-01 | 0.159 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.930430e-01 | 0.159 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.985813e-01 | 0.156 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.985813e-01 | 0.156 |
| R-HSA-2559583 | Cellular Senescence | 7.005224e-01 | 0.155 |
| R-HSA-3371556 | Cellular response to heat stress | 7.031517e-01 | 0.153 |
| R-HSA-109582 | Hemostasis | 7.036660e-01 | 0.153 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.040200e-01 | 0.152 |
| R-HSA-191859 | snRNP Assembly | 7.040200e-01 | 0.152 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 7.040200e-01 | 0.152 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.093609e-01 | 0.149 |
| R-HSA-162582 | Signal Transduction | 7.106101e-01 | 0.148 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.146058e-01 | 0.146 |
| R-HSA-450294 | MAP kinase activation | 7.146058e-01 | 0.146 |
| R-HSA-8956321 | Nucleotide salvage | 7.146058e-01 | 0.146 |
| R-HSA-1442490 | Collagen degradation | 7.146058e-01 | 0.146 |
| R-HSA-9679506 | SARS-CoV Infections | 7.195341e-01 | 0.143 |
| R-HSA-1268020 | Mitochondrial protein import | 7.197563e-01 | 0.143 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.197563e-01 | 0.143 |
| R-HSA-9707616 | Heme signaling | 7.197563e-01 | 0.143 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.218898e-01 | 0.142 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.218898e-01 | 0.142 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.218898e-01 | 0.142 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.248142e-01 | 0.140 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.297811e-01 | 0.137 |
| R-HSA-936837 | Ion transport by P-type ATPases | 7.297811e-01 | 0.137 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.346586e-01 | 0.134 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.394484e-01 | 0.131 |
| R-HSA-1474165 | Reproduction | 7.430522e-01 | 0.129 |
| R-HSA-196807 | Nicotinate metabolism | 7.441521e-01 | 0.128 |
| R-HSA-9843745 | Adipogenesis | 7.464426e-01 | 0.127 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.487711e-01 | 0.126 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 7.487711e-01 | 0.126 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.577613e-01 | 0.120 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.577613e-01 | 0.120 |
| R-HSA-204005 | COPII-mediated vesicle transport | 7.577613e-01 | 0.120 |
| R-HSA-448424 | Interleukin-17 signaling | 7.577613e-01 | 0.120 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.577613e-01 | 0.120 |
| R-HSA-8978934 | Metabolism of cofactors | 7.621354e-01 | 0.118 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.659895e-01 | 0.116 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.664308e-01 | 0.116 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.664308e-01 | 0.116 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.664308e-01 | 0.116 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.676530e-01 | 0.115 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.706489e-01 | 0.113 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 7.706489e-01 | 0.113 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.747911e-01 | 0.111 |
| R-HSA-5357801 | Programmed Cell Death | 7.754403e-01 | 0.110 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.782841e-01 | 0.109 |
| R-HSA-9664407 | Parasite infection | 7.782841e-01 | 0.109 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.782841e-01 | 0.109 |
| R-HSA-8852135 | Protein ubiquitination | 7.788587e-01 | 0.109 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.797963e-01 | 0.108 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.812684e-01 | 0.107 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.828531e-01 | 0.106 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.867756e-01 | 0.104 |
| R-HSA-74160 | Gene expression (Transcription) | 7.904487e-01 | 0.102 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.906275e-01 | 0.102 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.906275e-01 | 0.102 |
| R-HSA-216083 | Integrin cell surface interactions | 7.906275e-01 | 0.102 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.944100e-01 | 0.100 |
| R-HSA-6806834 | Signaling by MET | 7.981244e-01 | 0.098 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.981244e-01 | 0.098 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.981244e-01 | 0.098 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 8.017719e-01 | 0.096 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.053538e-01 | 0.094 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.088712e-01 | 0.092 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.123252e-01 | 0.090 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.157170e-01 | 0.088 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 8.190477e-01 | 0.087 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 8.190477e-01 | 0.087 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.223184e-01 | 0.085 |
| R-HSA-1483257 | Phospholipid metabolism | 8.239286e-01 | 0.084 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.241343e-01 | 0.084 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.252352e-01 | 0.083 |
| R-HSA-597592 | Post-translational protein modification | 8.285719e-01 | 0.082 |
| R-HSA-156902 | Peptide chain elongation | 8.286841e-01 | 0.082 |
| R-HSA-1236974 | ER-Phagosome pathway | 8.317812e-01 | 0.080 |
| R-HSA-202424 | Downstream TCR signaling | 8.348225e-01 | 0.078 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.378090e-01 | 0.077 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.436215e-01 | 0.074 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.464494e-01 | 0.072 |
| R-HSA-2029481 | FCGR activation | 8.464494e-01 | 0.072 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.492264e-01 | 0.071 |
| R-HSA-1474290 | Collagen formation | 8.492264e-01 | 0.071 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 8.519533e-01 | 0.070 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.555570e-01 | 0.068 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.572606e-01 | 0.067 |
| R-HSA-1296071 | Potassium Channels | 8.572606e-01 | 0.067 |
| R-HSA-72306 | tRNA processing | 8.578031e-01 | 0.067 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.598083e-01 | 0.066 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 8.598427e-01 | 0.066 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.617877e-01 | 0.065 |
| R-HSA-190236 | Signaling by FGFR | 8.623782e-01 | 0.064 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.623782e-01 | 0.064 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.623782e-01 | 0.064 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.623782e-01 | 0.064 |
| R-HSA-3214847 | HATs acetylate histones | 8.648680e-01 | 0.063 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.656701e-01 | 0.063 |
| R-HSA-6798695 | Neutrophil degranulation | 8.664426e-01 | 0.062 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 8.673129e-01 | 0.062 |
| R-HSA-70171 | Glycolysis | 8.673129e-01 | 0.062 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.675737e-01 | 0.062 |
| R-HSA-9020702 | Interleukin-1 signaling | 8.697138e-01 | 0.061 |
| R-HSA-168255 | Influenza Infection | 8.749434e-01 | 0.058 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 8.788919e-01 | 0.056 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 8.788919e-01 | 0.056 |
| R-HSA-9833110 | RSV-host interactions | 8.788919e-01 | 0.056 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.810839e-01 | 0.055 |
| R-HSA-418346 | Platelet homeostasis | 8.832364e-01 | 0.054 |
| R-HSA-3781865 | Diseases of glycosylation | 8.836252e-01 | 0.054 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.853500e-01 | 0.053 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.874255e-01 | 0.052 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.874255e-01 | 0.052 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.894636e-01 | 0.051 |
| R-HSA-202403 | TCR signaling | 8.914649e-01 | 0.050 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.914649e-01 | 0.050 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.914649e-01 | 0.050 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.972546e-01 | 0.047 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.976340e-01 | 0.047 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.993431e-01 | 0.046 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.027366e-01 | 0.044 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 9.027366e-01 | 0.044 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.044983e-01 | 0.044 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.044983e-01 | 0.044 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.044983e-01 | 0.044 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.062282e-01 | 0.043 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.062282e-01 | 0.043 |
| R-HSA-446728 | Cell junction organization | 9.075610e-01 | 0.042 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.078027e-01 | 0.042 |
| R-HSA-70326 | Glucose metabolism | 9.079270e-01 | 0.042 |
| R-HSA-2980736 | Peptide hormone metabolism | 9.079270e-01 | 0.042 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.087396e-01 | 0.042 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.095950e-01 | 0.041 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.112329e-01 | 0.040 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.112329e-01 | 0.040 |
| R-HSA-72172 | mRNA Splicing | 9.143408e-01 | 0.039 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.144206e-01 | 0.039 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 9.159713e-01 | 0.038 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 9.159713e-01 | 0.038 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.174941e-01 | 0.037 |
| R-HSA-6809371 | Formation of the cornified envelope | 9.189894e-01 | 0.037 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 9.198000e-01 | 0.036 |
| R-HSA-212436 | Generic Transcription Pathway | 9.212106e-01 | 0.036 |
| R-HSA-194138 | Signaling by VEGF | 9.218994e-01 | 0.035 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.233151e-01 | 0.035 |
| R-HSA-114608 | Platelet degranulation | 9.247052e-01 | 0.034 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.268012e-01 | 0.033 |
| R-HSA-8956319 | Nucleotide catabolism | 9.274106e-01 | 0.033 |
| R-HSA-195721 | Signaling by WNT | 9.286964e-01 | 0.032 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.287267e-01 | 0.032 |
| R-HSA-9909396 | Circadian clock | 9.325341e-01 | 0.030 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.325341e-01 | 0.030 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 9.337576e-01 | 0.030 |
| R-HSA-5173105 | O-linked glycosylation | 9.395514e-01 | 0.027 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.395514e-01 | 0.027 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.406481e-01 | 0.027 |
| R-HSA-6807070 | PTEN Regulation | 9.417249e-01 | 0.026 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.418803e-01 | 0.026 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.431476e-01 | 0.025 |
| R-HSA-1500931 | Cell-Cell communication | 9.438351e-01 | 0.025 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.458411e-01 | 0.024 |
| R-HSA-15869 | Metabolism of nucleotides | 9.469197e-01 | 0.024 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.477181e-01 | 0.023 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.477892e-01 | 0.023 |
| R-HSA-8953854 | Metabolism of RNA | 9.499260e-01 | 0.022 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.514783e-01 | 0.022 |
| R-HSA-166520 | Signaling by NTRKs | 9.514783e-01 | 0.022 |
| R-HSA-5663205 | Infectious disease | 9.525648e-01 | 0.021 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.532243e-01 | 0.021 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.540737e-01 | 0.020 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.549077e-01 | 0.020 |
| R-HSA-9609507 | Protein localization | 9.557265e-01 | 0.020 |
| R-HSA-1989781 | PPARA activates gene expression | 9.573201e-01 | 0.019 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.573201e-01 | 0.019 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.588566e-01 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.599689e-01 | 0.018 |
| R-HSA-168256 | Immune System | 9.608376e-01 | 0.017 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.608824e-01 | 0.017 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.610584e-01 | 0.017 |
| R-HSA-109581 | Apoptosis | 9.624607e-01 | 0.017 |
| R-HSA-72766 | Translation | 9.638362e-01 | 0.016 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.641388e-01 | 0.016 |
| R-HSA-5619102 | SLC transporter disorders | 9.657502e-01 | 0.015 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.674938e-01 | 0.014 |
| R-HSA-418555 | G alpha (s) signalling events | 9.687522e-01 | 0.014 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.698783e-01 | 0.013 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.698783e-01 | 0.013 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.698783e-01 | 0.013 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.698783e-01 | 0.013 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.703835e-01 | 0.013 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.706142e-01 | 0.013 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.708807e-01 | 0.013 |
| R-HSA-9658195 | Leishmania infection | 9.734430e-01 | 0.012 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.734430e-01 | 0.012 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.749301e-01 | 0.011 |
| R-HSA-983712 | Ion channel transport | 9.775461e-01 | 0.010 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.783562e-01 | 0.010 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.786746e-01 | 0.009 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.787502e-01 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.801071e-01 | 0.009 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.802561e-01 | 0.009 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.826401e-01 | 0.008 |
| R-HSA-6805567 | Keratinization | 9.838712e-01 | 0.007 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.858199e-01 | 0.006 |
| R-HSA-418990 | Adherens junctions interactions | 9.870664e-01 | 0.006 |
| R-HSA-1474244 | Extracellular matrix organization | 9.879584e-01 | 0.005 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.892413e-01 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 9.894447e-01 | 0.005 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.899075e-01 | 0.004 |
| R-HSA-1643685 | Disease | 9.923294e-01 | 0.003 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.924195e-01 | 0.003 |
| R-HSA-421270 | Cell-cell junction organization | 9.929585e-01 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.959423e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.975282e-01 | 0.001 |
| R-HSA-8957322 | Metabolism of steroids | 9.981737e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.986492e-01 | 0.001 |
| R-HSA-449147 | Signaling by Interleukins | 9.994385e-01 | 0.000 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.995114e-01 | 0.000 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.998434e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.999042e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.999873e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.999876e-01 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 9.999939e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999985e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | -0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK17 |
0.883 | 0.882 | 1 | 0.862 |
CDK19 |
0.880 | 0.835 | 1 | 0.815 |
CDK18 |
0.879 | 0.854 | 1 | 0.831 |
P38G |
0.878 | 0.893 | 1 | 0.870 |
CDK8 |
0.878 | 0.844 | 1 | 0.780 |
CDK7 |
0.874 | 0.835 | 1 | 0.785 |
CDK5 |
0.872 | 0.828 | 1 | 0.756 |
CDK13 |
0.872 | 0.850 | 1 | 0.807 |
CDK16 |
0.872 | 0.844 | 1 | 0.849 |
P38D |
0.871 | 0.870 | 1 | 0.873 |
CDK3 |
0.871 | 0.764 | 1 | 0.855 |
JNK2 |
0.870 | 0.888 | 1 | 0.832 |
ERK1 |
0.870 | 0.849 | 1 | 0.815 |
CDK1 |
0.869 | 0.833 | 1 | 0.811 |
CDK12 |
0.868 | 0.845 | 1 | 0.829 |
HIPK2 |
0.866 | 0.764 | 1 | 0.810 |
KIS |
0.866 | 0.736 | 1 | 0.758 |
CDK9 |
0.865 | 0.839 | 1 | 0.801 |
P38B |
0.865 | 0.844 | 1 | 0.799 |
JNK3 |
0.864 | 0.881 | 1 | 0.805 |
CDK10 |
0.860 | 0.790 | 1 | 0.807 |
ERK2 |
0.860 | 0.855 | 1 | 0.765 |
CDK14 |
0.859 | 0.828 | 1 | 0.789 |
P38A |
0.857 | 0.818 | 1 | 0.727 |
DYRK2 |
0.857 | 0.747 | 1 | 0.724 |
CDK4 |
0.856 | 0.835 | 1 | 0.835 |
CDK6 |
0.855 | 0.811 | 1 | 0.810 |
NLK |
0.850 | 0.755 | 1 | 0.515 |
DYRK1B |
0.849 | 0.740 | 1 | 0.775 |
DYRK4 |
0.848 | 0.756 | 1 | 0.822 |
HIPK1 |
0.848 | 0.695 | 1 | 0.703 |
CDK2 |
0.846 | 0.652 | 1 | 0.686 |
HIPK4 |
0.844 | 0.465 | 1 | 0.507 |
HIPK3 |
0.844 | 0.684 | 1 | 0.678 |
CLK3 |
0.844 | 0.477 | 1 | 0.478 |
ERK5 |
0.841 | 0.425 | 1 | 0.431 |
JNK1 |
0.840 | 0.785 | 1 | 0.832 |
DYRK1A |
0.840 | 0.611 | 1 | 0.689 |
SRPK1 |
0.831 | 0.327 | -3 | 0.721 |
DYRK3 |
0.829 | 0.545 | 1 | 0.666 |
MTOR |
0.829 | 0.223 | 1 | 0.313 |
CLK1 |
0.827 | 0.408 | -3 | 0.721 |
SRPK2 |
0.826 | 0.274 | -3 | 0.652 |
CDKL5 |
0.826 | 0.172 | -3 | 0.774 |
ICK |
0.825 | 0.355 | -3 | 0.812 |
CDKL1 |
0.822 | 0.148 | -3 | 0.781 |
CLK4 |
0.822 | 0.368 | -3 | 0.740 |
COT |
0.820 | -0.089 | 2 | 0.894 |
MAK |
0.817 | 0.486 | -2 | 0.748 |
MOK |
0.815 | 0.466 | 1 | 0.591 |
CDC7 |
0.815 | -0.113 | 1 | 0.144 |
TBK1 |
0.815 | -0.151 | 1 | 0.106 |
CLK2 |
0.815 | 0.385 | -3 | 0.720 |
PRP4 |
0.815 | 0.444 | -3 | 0.721 |
PRPK |
0.814 | -0.080 | -1 | 0.878 |
ERK7 |
0.813 | 0.291 | 2 | 0.593 |
SRPK3 |
0.811 | 0.229 | -3 | 0.699 |
ULK2 |
0.810 | -0.162 | 2 | 0.829 |
MST4 |
0.810 | -0.014 | 2 | 0.900 |
GCN2 |
0.810 | -0.188 | 2 | 0.824 |
IKKE |
0.810 | -0.164 | 1 | 0.104 |
PKN3 |
0.809 | -0.037 | -3 | 0.805 |
MOS |
0.809 | -0.066 | 1 | 0.180 |
NUAK2 |
0.809 | 0.014 | -3 | 0.805 |
DSTYK |
0.808 | -0.120 | 2 | 0.905 |
PDHK4 |
0.808 | -0.151 | 1 | 0.190 |
PDHK1 |
0.808 | -0.135 | 1 | 0.166 |
ATR |
0.808 | -0.062 | 1 | 0.185 |
RAF1 |
0.807 | -0.200 | 1 | 0.124 |
BMPR2 |
0.806 | -0.153 | -2 | 0.896 |
NEK6 |
0.806 | -0.074 | -2 | 0.858 |
WNK1 |
0.806 | -0.072 | -2 | 0.897 |
PKCD |
0.806 | -0.007 | 2 | 0.852 |
PIM3 |
0.805 | -0.057 | -3 | 0.802 |
TGFBR2 |
0.805 | -0.078 | -2 | 0.783 |
CAMK1B |
0.805 | -0.058 | -3 | 0.847 |
PRKD1 |
0.805 | -0.036 | -3 | 0.792 |
NDR2 |
0.804 | -0.043 | -3 | 0.800 |
NIK |
0.804 | -0.058 | -3 | 0.863 |
IRE2 |
0.804 | -0.037 | 2 | 0.823 |
IKKB |
0.803 | -0.184 | -2 | 0.800 |
IRE1 |
0.803 | -0.067 | 1 | 0.118 |
MARK4 |
0.803 | -0.051 | 4 | 0.820 |
MLK1 |
0.802 | -0.117 | 2 | 0.868 |
CHAK2 |
0.802 | -0.055 | -1 | 0.892 |
NEK7 |
0.801 | -0.162 | -3 | 0.810 |
WNK3 |
0.801 | -0.165 | 1 | 0.124 |
ULK1 |
0.801 | -0.154 | -3 | 0.804 |
AMPKA1 |
0.801 | -0.066 | -3 | 0.821 |
PKN2 |
0.801 | -0.063 | -3 | 0.812 |
NUAK1 |
0.800 | -0.026 | -3 | 0.765 |
NDR1 |
0.799 | -0.073 | -3 | 0.804 |
PHKG1 |
0.799 | -0.049 | -3 | 0.795 |
MLK2 |
0.799 | -0.103 | 2 | 0.866 |
NIM1 |
0.799 | -0.070 | 3 | 0.844 |
AMPKA2 |
0.798 | -0.046 | -3 | 0.786 |
BCKDK |
0.798 | -0.140 | -1 | 0.840 |
MLK3 |
0.798 | -0.037 | 2 | 0.813 |
P90RSK |
0.798 | -0.027 | -3 | 0.746 |
CAMLCK |
0.798 | -0.045 | -2 | 0.852 |
PINK1 |
0.797 | 0.190 | 1 | 0.330 |
RIPK3 |
0.797 | -0.160 | 3 | 0.803 |
CAMK2G |
0.797 | -0.125 | 2 | 0.807 |
NEK9 |
0.797 | -0.157 | 2 | 0.882 |
PRKD2 |
0.796 | -0.031 | -3 | 0.730 |
HUNK |
0.796 | -0.166 | 2 | 0.813 |
PIM1 |
0.796 | -0.003 | -3 | 0.750 |
DAPK2 |
0.796 | -0.070 | -3 | 0.848 |
RSK3 |
0.795 | -0.047 | -3 | 0.740 |
DNAPK |
0.795 | -0.038 | 1 | 0.186 |
LATS2 |
0.795 | -0.051 | -5 | 0.829 |
RSK2 |
0.795 | -0.037 | -3 | 0.744 |
PKCA |
0.795 | -0.006 | 2 | 0.805 |
MASTL |
0.794 | -0.170 | -2 | 0.846 |
MELK |
0.794 | -0.071 | -3 | 0.781 |
IKKA |
0.794 | -0.108 | -2 | 0.784 |
TSSK1 |
0.794 | -0.062 | -3 | 0.837 |
MAPKAPK3 |
0.794 | -0.083 | -3 | 0.748 |
PKCZ |
0.793 | -0.030 | 2 | 0.839 |
ANKRD3 |
0.793 | -0.142 | 1 | 0.142 |
QIK |
0.793 | -0.083 | -3 | 0.815 |
PKCB |
0.793 | -0.021 | 2 | 0.812 |
PKCG |
0.792 | -0.031 | 2 | 0.808 |
P70S6KB |
0.792 | -0.038 | -3 | 0.774 |
ATM |
0.792 | -0.084 | 1 | 0.160 |
GRK5 |
0.792 | -0.179 | -3 | 0.856 |
TSSK2 |
0.791 | -0.100 | -5 | 0.893 |
VRK2 |
0.791 | 0.059 | 1 | 0.225 |
QSK |
0.791 | -0.036 | 4 | 0.809 |
SKMLCK |
0.791 | -0.104 | -2 | 0.844 |
SIK |
0.791 | -0.041 | -3 | 0.735 |
CAMK2D |
0.791 | -0.120 | -3 | 0.824 |
PKR |
0.791 | -0.074 | 1 | 0.137 |
RIPK1 |
0.790 | -0.198 | 1 | 0.117 |
PHKG2 |
0.790 | -0.048 | -3 | 0.775 |
CHAK1 |
0.790 | -0.114 | 2 | 0.828 |
PRKD3 |
0.789 | -0.034 | -3 | 0.715 |
PKCH |
0.789 | -0.044 | 2 | 0.797 |
YSK4 |
0.789 | -0.138 | 1 | 0.109 |
BRSK2 |
0.789 | -0.080 | -3 | 0.796 |
NEK2 |
0.788 | -0.123 | 2 | 0.860 |
MPSK1 |
0.788 | 0.030 | 1 | 0.184 |
IRAK4 |
0.788 | -0.080 | 1 | 0.104 |
MNK2 |
0.787 | -0.061 | -2 | 0.787 |
DLK |
0.787 | -0.228 | 1 | 0.138 |
ALK4 |
0.787 | -0.068 | -2 | 0.841 |
SMG1 |
0.787 | -0.081 | 1 | 0.172 |
MAPKAPK2 |
0.787 | -0.062 | -3 | 0.700 |
LATS1 |
0.787 | -0.018 | -3 | 0.815 |
PKACG |
0.786 | -0.073 | -2 | 0.707 |
BMPR1B |
0.786 | -0.064 | 1 | 0.112 |
PAK3 |
0.786 | -0.098 | -2 | 0.785 |
MLK4 |
0.786 | -0.097 | 2 | 0.784 |
PKCT |
0.786 | -0.034 | 2 | 0.808 |
CAMK4 |
0.785 | -0.136 | -3 | 0.799 |
GRK1 |
0.785 | -0.088 | -2 | 0.779 |
PAK6 |
0.785 | -0.039 | -2 | 0.729 |
AURC |
0.784 | -0.028 | -2 | 0.627 |
TGFBR1 |
0.784 | -0.068 | -2 | 0.810 |
MARK2 |
0.784 | -0.051 | 4 | 0.730 |
WNK4 |
0.783 | -0.094 | -2 | 0.904 |
MARK3 |
0.783 | -0.045 | 4 | 0.770 |
TTBK2 |
0.783 | -0.210 | 2 | 0.733 |
CHK1 |
0.783 | -0.067 | -3 | 0.800 |
BRSK1 |
0.782 | -0.077 | -3 | 0.763 |
MEK1 |
0.782 | -0.156 | 2 | 0.838 |
MEKK1 |
0.782 | -0.118 | 1 | 0.132 |
MSK2 |
0.782 | -0.073 | -3 | 0.714 |
MNK1 |
0.782 | -0.052 | -2 | 0.788 |
GRK6 |
0.782 | -0.183 | 1 | 0.125 |
HRI |
0.781 | -0.135 | -2 | 0.856 |
ZAK |
0.781 | -0.130 | 1 | 0.120 |
PAK1 |
0.781 | -0.089 | -2 | 0.776 |
PKCI |
0.780 | -0.019 | 2 | 0.811 |
SGK3 |
0.780 | -0.040 | -3 | 0.735 |
PIM2 |
0.780 | -0.005 | -3 | 0.725 |
SNRK |
0.780 | -0.151 | 2 | 0.716 |
AKT2 |
0.779 | -0.007 | -3 | 0.659 |
PLK4 |
0.779 | -0.131 | 2 | 0.653 |
MST3 |
0.779 | -0.042 | 2 | 0.883 |
CAMK1G |
0.778 | -0.068 | -3 | 0.742 |
PERK |
0.778 | -0.146 | -2 | 0.844 |
RSK4 |
0.778 | -0.034 | -3 | 0.703 |
ACVR2A |
0.778 | -0.110 | -2 | 0.788 |
MARK1 |
0.778 | -0.077 | 4 | 0.794 |
MEKK2 |
0.778 | -0.105 | 2 | 0.846 |
MEK5 |
0.778 | -0.146 | 2 | 0.854 |
AURB |
0.777 | -0.048 | -2 | 0.626 |
FAM20C |
0.777 | -0.042 | 2 | 0.592 |
PLK1 |
0.777 | -0.180 | -2 | 0.791 |
PKN1 |
0.777 | -0.028 | -3 | 0.705 |
DRAK1 |
0.776 | -0.151 | 1 | 0.117 |
ACVR2B |
0.776 | -0.116 | -2 | 0.793 |
TAO3 |
0.776 | -0.044 | 1 | 0.156 |
DCAMKL1 |
0.776 | -0.069 | -3 | 0.745 |
GSK3A |
0.776 | 0.158 | 4 | 0.369 |
GRK7 |
0.776 | -0.059 | 1 | 0.161 |
PAK2 |
0.776 | -0.109 | -2 | 0.770 |
PKG2 |
0.776 | -0.053 | -2 | 0.638 |
MAPKAPK5 |
0.775 | -0.110 | -3 | 0.703 |
CAMK2B |
0.775 | -0.102 | 2 | 0.761 |
AKT1 |
0.775 | -0.017 | -3 | 0.673 |
TAO2 |
0.775 | -0.030 | 2 | 0.900 |
BRAF |
0.774 | -0.135 | -4 | 0.853 |
ALK2 |
0.774 | -0.098 | -2 | 0.814 |
NEK5 |
0.774 | -0.142 | 1 | 0.122 |
GRK4 |
0.774 | -0.220 | -2 | 0.798 |
CAMK2A |
0.773 | -0.076 | 2 | 0.777 |
MYLK4 |
0.773 | -0.076 | -2 | 0.750 |
TLK2 |
0.772 | -0.164 | 1 | 0.114 |
BMPR1A |
0.772 | -0.067 | 1 | 0.104 |
PKCE |
0.772 | 0.000 | 2 | 0.799 |
SSTK |
0.772 | -0.078 | 4 | 0.803 |
DCAMKL2 |
0.771 | -0.074 | -3 | 0.778 |
MAP3K15 |
0.771 | -0.079 | 1 | 0.135 |
MEKK3 |
0.770 | -0.188 | 1 | 0.129 |
PKACB |
0.770 | -0.036 | -2 | 0.635 |
HGK |
0.770 | -0.055 | 3 | 0.896 |
NEK11 |
0.769 | -0.129 | 1 | 0.152 |
SMMLCK |
0.769 | -0.059 | -3 | 0.803 |
MSK1 |
0.769 | -0.069 | -3 | 0.721 |
PLK3 |
0.769 | -0.163 | 2 | 0.758 |
NEK8 |
0.769 | -0.141 | 2 | 0.872 |
PDK1 |
0.768 | -0.072 | 1 | 0.173 |
P70S6K |
0.768 | -0.057 | -3 | 0.690 |
GAK |
0.768 | -0.043 | 1 | 0.175 |
MEKK6 |
0.768 | -0.090 | 1 | 0.131 |
GRK2 |
0.768 | -0.115 | -2 | 0.696 |
IRAK1 |
0.768 | -0.185 | -1 | 0.778 |
MINK |
0.767 | -0.093 | 1 | 0.107 |
NEK4 |
0.767 | -0.136 | 1 | 0.106 |
PAK5 |
0.766 | -0.069 | -2 | 0.655 |
LRRK2 |
0.766 | -0.008 | 2 | 0.883 |
TLK1 |
0.766 | -0.167 | -2 | 0.799 |
LKB1 |
0.765 | -0.080 | -3 | 0.808 |
CAMKK1 |
0.765 | -0.166 | -2 | 0.833 |
TNIK |
0.765 | -0.046 | 3 | 0.884 |
TTBK1 |
0.765 | -0.166 | 2 | 0.653 |
MST2 |
0.765 | -0.108 | 1 | 0.117 |
GCK |
0.764 | -0.085 | 1 | 0.132 |
PRKX |
0.764 | -0.018 | -3 | 0.633 |
KHS1 |
0.764 | -0.041 | 1 | 0.126 |
AURA |
0.763 | -0.068 | -2 | 0.595 |
LOK |
0.763 | -0.071 | -2 | 0.803 |
SBK |
0.763 | 0.089 | -3 | 0.545 |
EEF2K |
0.763 | -0.072 | 3 | 0.863 |
GSK3B |
0.762 | 0.006 | 4 | 0.362 |
PBK |
0.762 | -0.041 | 1 | 0.157 |
YSK1 |
0.762 | -0.077 | 2 | 0.867 |
CAMK1D |
0.762 | -0.066 | -3 | 0.668 |
NEK3 |
0.761 | -0.087 | 1 | 0.134 |
CAMKK2 |
0.761 | -0.141 | -2 | 0.832 |
PAK4 |
0.761 | -0.063 | -2 | 0.653 |
CHK2 |
0.760 | -0.037 | -3 | 0.610 |
NEK1 |
0.760 | -0.136 | 1 | 0.104 |
HPK1 |
0.760 | -0.086 | 1 | 0.134 |
KHS2 |
0.760 | -0.024 | 1 | 0.138 |
RIPK2 |
0.760 | -0.176 | 1 | 0.107 |
CK1E |
0.760 | -0.066 | -3 | 0.512 |
VRK1 |
0.760 | -0.130 | 2 | 0.877 |
MST1 |
0.759 | -0.104 | 1 | 0.106 |
BIKE |
0.758 | -0.012 | 1 | 0.168 |
BUB1 |
0.758 | -0.023 | -5 | 0.839 |
AKT3 |
0.758 | -0.018 | -3 | 0.591 |
SLK |
0.758 | -0.061 | -2 | 0.746 |
PKACA |
0.757 | -0.045 | -2 | 0.584 |
PASK |
0.756 | -0.103 | -3 | 0.809 |
HASPIN |
0.755 | -0.009 | -1 | 0.692 |
CAMK1A |
0.755 | -0.047 | -3 | 0.626 |
SGK1 |
0.755 | -0.002 | -3 | 0.582 |
AAK1 |
0.755 | 0.019 | 1 | 0.177 |
MRCKB |
0.755 | -0.033 | -3 | 0.715 |
TAK1 |
0.755 | -0.179 | 1 | 0.116 |
DAPK3 |
0.753 | -0.075 | -3 | 0.766 |
MRCKA |
0.753 | -0.044 | -3 | 0.735 |
TAO1 |
0.752 | -0.056 | 1 | 0.126 |
ROCK2 |
0.751 | -0.042 | -3 | 0.758 |
CK1D |
0.751 | -0.044 | -3 | 0.465 |
MEK2 |
0.751 | -0.190 | 2 | 0.828 |
CK1G1 |
0.750 | -0.103 | -3 | 0.515 |
CK2A2 |
0.749 | -0.105 | 1 | 0.098 |
DMPK1 |
0.748 | -0.003 | -3 | 0.731 |
PDHK3_TYR |
0.747 | 0.095 | 4 | 0.848 |
MYO3B |
0.747 | -0.058 | 2 | 0.881 |
ASK1 |
0.746 | -0.112 | 1 | 0.135 |
PKMYT1_TYR |
0.746 | 0.154 | 3 | 0.888 |
MYO3A |
0.745 | -0.062 | 1 | 0.121 |
GRK3 |
0.745 | -0.132 | -2 | 0.640 |
STK33 |
0.745 | -0.154 | 2 | 0.632 |
LIMK2_TYR |
0.744 | 0.109 | -3 | 0.878 |
TTK |
0.744 | -0.080 | -2 | 0.792 |
CK1A2 |
0.744 | -0.072 | -3 | 0.463 |
DAPK1 |
0.743 | -0.089 | -3 | 0.748 |
TESK1_TYR |
0.743 | 0.032 | 3 | 0.909 |
PKG1 |
0.743 | -0.067 | -2 | 0.560 |
ROCK1 |
0.742 | -0.043 | -3 | 0.730 |
CRIK |
0.741 | -0.020 | -3 | 0.673 |
OSR1 |
0.740 | -0.104 | 2 | 0.826 |
CK2A1 |
0.739 | -0.116 | 1 | 0.091 |
PLK2 |
0.738 | -0.118 | -3 | 0.787 |
LIMK1_TYR |
0.738 | 0.038 | 2 | 0.893 |
TNNI3K_TYR |
0.737 | 0.017 | 1 | 0.159 |
PINK1_TYR |
0.736 | -0.096 | 1 | 0.183 |
MAP2K7_TYR |
0.736 | -0.086 | 2 | 0.879 |
TYK2 |
0.736 | -0.132 | 1 | 0.138 |
PDHK4_TYR |
0.736 | 0.004 | 2 | 0.885 |
MAP2K4_TYR |
0.735 | -0.042 | -1 | 0.899 |
JAK2 |
0.735 | -0.084 | 1 | 0.162 |
ROS1 |
0.734 | -0.085 | 3 | 0.868 |
JAK1 |
0.733 | -0.041 | 1 | 0.135 |
MAP2K6_TYR |
0.733 | -0.028 | -1 | 0.908 |
RET |
0.732 | -0.130 | 1 | 0.151 |
MST1R |
0.732 | -0.088 | 3 | 0.866 |
NEK10_TYR |
0.731 | -0.077 | 1 | 0.136 |
CSF1R |
0.731 | -0.079 | 3 | 0.856 |
JAK3 |
0.730 | -0.088 | 1 | 0.150 |
BMPR2_TYR |
0.730 | -0.031 | -1 | 0.876 |
TYRO3 |
0.728 | -0.134 | 3 | 0.880 |
ALPHAK3 |
0.728 | -0.117 | -1 | 0.789 |
PDHK1_TYR |
0.727 | -0.107 | -1 | 0.912 |
FGFR1 |
0.727 | -0.006 | 3 | 0.843 |
STLK3 |
0.726 | -0.182 | 1 | 0.104 |
TNK1 |
0.724 | -0.061 | 3 | 0.852 |
TEK |
0.724 | 0.003 | 3 | 0.828 |
EPHA6 |
0.723 | -0.120 | -1 | 0.850 |
PDGFRB |
0.722 | -0.153 | 3 | 0.880 |
FGFR2 |
0.722 | -0.046 | 3 | 0.842 |
YES1 |
0.721 | -0.101 | -1 | 0.843 |
DDR1 |
0.721 | -0.141 | 4 | 0.777 |
FLT3 |
0.721 | -0.136 | 3 | 0.873 |
EPHB4 |
0.721 | -0.145 | -1 | 0.836 |
ABL2 |
0.719 | -0.138 | -1 | 0.797 |
INSRR |
0.719 | -0.132 | 3 | 0.827 |
PDGFRA |
0.719 | -0.161 | 3 | 0.878 |
FGR |
0.718 | -0.164 | 1 | 0.113 |
LCK |
0.718 | -0.101 | -1 | 0.814 |
TXK |
0.718 | -0.112 | 1 | 0.110 |
KDR |
0.718 | -0.083 | 3 | 0.818 |
YANK3 |
0.717 | -0.091 | 2 | 0.398 |
HCK |
0.716 | -0.146 | -1 | 0.815 |
ABL1 |
0.716 | -0.141 | -1 | 0.788 |
KIT |
0.716 | -0.130 | 3 | 0.856 |
TNK2 |
0.715 | -0.125 | 3 | 0.825 |
BLK |
0.715 | -0.091 | -1 | 0.820 |
ITK |
0.714 | -0.145 | -1 | 0.791 |
FER |
0.714 | -0.203 | 1 | 0.129 |
WEE1_TYR |
0.714 | -0.069 | -1 | 0.754 |
ALK |
0.712 | -0.138 | 3 | 0.822 |
EPHB1 |
0.712 | -0.182 | 1 | 0.111 |
AXL |
0.710 | -0.181 | 3 | 0.842 |
DDR2 |
0.710 | -0.046 | 3 | 0.814 |
EPHB3 |
0.709 | -0.184 | -1 | 0.815 |
BTK |
0.708 | -0.199 | -1 | 0.750 |
EPHA4 |
0.708 | -0.131 | 2 | 0.750 |
EPHB2 |
0.708 | -0.166 | -1 | 0.810 |
FGFR3 |
0.707 | -0.077 | 3 | 0.814 |
MET |
0.707 | -0.137 | 3 | 0.844 |
INSR |
0.707 | -0.145 | 3 | 0.805 |
FLT4 |
0.707 | -0.133 | 3 | 0.804 |
FRK |
0.707 | -0.147 | -1 | 0.816 |
NTRK2 |
0.706 | -0.183 | 3 | 0.822 |
SRMS |
0.706 | -0.214 | 1 | 0.104 |
TEC |
0.706 | -0.155 | -1 | 0.716 |
MERTK |
0.706 | -0.182 | 3 | 0.831 |
ERBB2 |
0.706 | -0.163 | 1 | 0.125 |
BMX |
0.704 | -0.139 | -1 | 0.688 |
MUSK |
0.704 | -0.113 | 1 | 0.088 |
LTK |
0.704 | -0.170 | 3 | 0.822 |
FYN |
0.704 | -0.104 | -1 | 0.791 |
CK1A |
0.703 | -0.098 | -3 | 0.374 |
FLT1 |
0.702 | -0.148 | -1 | 0.840 |
EPHA1 |
0.702 | -0.176 | 3 | 0.830 |
NTRK1 |
0.701 | -0.221 | -1 | 0.829 |
LYN |
0.701 | -0.144 | 3 | 0.796 |
EGFR |
0.700 | -0.120 | 1 | 0.108 |
EPHA7 |
0.699 | -0.160 | 2 | 0.763 |
NTRK3 |
0.699 | -0.166 | -1 | 0.774 |
PTK6 |
0.698 | -0.223 | -1 | 0.720 |
SRC |
0.696 | -0.134 | -1 | 0.788 |
PTK2B |
0.695 | -0.143 | -1 | 0.758 |
EPHA3 |
0.694 | -0.178 | 2 | 0.738 |
MATK |
0.694 | -0.124 | -1 | 0.727 |
EPHA8 |
0.691 | -0.147 | -1 | 0.787 |
CSK |
0.691 | -0.170 | 2 | 0.772 |
FGFR4 |
0.689 | -0.130 | -1 | 0.766 |
EPHA5 |
0.689 | -0.175 | 2 | 0.737 |
IGF1R |
0.686 | -0.154 | 3 | 0.751 |
ERBB4 |
0.684 | -0.114 | 1 | 0.105 |
YANK2 |
0.684 | -0.108 | 2 | 0.411 |
PTK2 |
0.682 | -0.103 | -1 | 0.780 |
CK1G3 |
0.681 | -0.100 | -3 | 0.325 |
SYK |
0.680 | -0.132 | -1 | 0.766 |
EPHA2 |
0.680 | -0.158 | -1 | 0.750 |
FES |
0.672 | -0.156 | -1 | 0.671 |
ZAP70 |
0.668 | -0.101 | -1 | 0.685 |
CK1G2 |
0.654 | -0.112 | -3 | 0.424 |