Motif 248 (n=119)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| F8WAN1 | SPECC1L-ADORA2A | S48 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| J3KQ70 | INO80B-WBP1 | S97 | ochoa | HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) | None |
| O00170 | AIP | S159 | ochoa | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00178 | GTPBP1 | S69 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O14974 | PPP1R12A | S445 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14978 | ZNF263 | S166 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
| O15014 | ZNF609 | S433 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15211 | RGL2 | S409 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15226 | NKRF | S325 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O43166 | SIPA1L1 | S1255 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O60264 | SMARCA5 | S171 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60701 | UGDH | S40 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75369 | FLNB | S846 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75381 | PEX14 | S44 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75534 | CSDE1 | S116 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O94782 | USP1 | S398 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94885 | SASH1 | S101 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| P18031 | PTPN1 | S50 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P18848 | ATF4 | S58 | ochoa | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:16682973, PubMed:17684156, PubMed:31023583, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:31023583, PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:31023583, PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}. |
| P21817 | RYR1 | S3566 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P27816 | MAP4 | S787 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28749 | RBL1 | S762 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P42331 | ARHGAP25 | S533 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46013 | MKI67 | S538 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S1666 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S790 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49458 | SRP9 | S34 | ochoa | Signal recognition particle 9 kDa protein (SRP9) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). {ECO:0000250|UniProtKB:P21262, ECO:0000269|PubMed:11089964}. |
| P53621 | COPA | S1193 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P56270 | MAZ | S414 | ochoa | Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801) | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}. |
| P62491 | RAB11A | S190 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P78347 | GTF2I | S515 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78347 | GTF2I | S620 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q12888 | TP53BP1 | S166 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q14315 | FLNC | S868 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1156 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1540 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14432 | PDE3A | S593 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14690 | PDCD11 | S144 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q15051 | IQCB1 | S20 | ochoa | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). {ECO:0000269|PubMed:23446637, ECO:0000269|PubMed:25552655}. |
| Q15699 | ALX1 | S69 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q15772 | SPEG | S2130 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S2343 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15942 | ZYX | S142 | ochoa|psp | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16625 | OCLN | S358 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2LD37 | BLTP1 | S4894 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2TAL8 | QRICH1 | S345 | ochoa | Transcriptional regulator QRICH1 (Glutamine-rich protein 1) | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. |
| Q3T8J9 | GON4L | S1268 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q4AC94 | C2CD3 | S2114 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q5BKY9 | FAM133B | S25 | ochoa | Protein FAM133B | None |
| Q5W0Q7 | USPL1 | S200 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q641Q2 | WASHC2A | S996 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68CQ4 | UTP25 | S273 | ochoa | U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) | Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}. |
| Q69YQ0 | SPECC1L | S48 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6NYC8 | PPP1R18 | S401 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6NZY4 | ZCCHC8 | S557 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P1M3 | LLGL2 | S802 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PJT7 | ZC3H14 | S527 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6PJW8 | CNST | S175 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6T4R5 | NHS | S418 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6W2J9 | BCOR | S1127 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZN55 | ZNF574 | S534 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZNB6 | NFXL1 | S356 | ochoa | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | None |
| Q7Z6I6 | ARHGAP30 | S1043 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86TB9 | PATL1 | S291 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86VS8 | HOOK3 | S162 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86X51 | EZHIP | S410 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q8IV48 | ERI1 | S21 | ochoa | 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}. |
| Q8IW41 | MAPKAPK5 | S354 | ochoa|psp | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IWZ8 | SUGP1 | S409 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IZC7 | ZNF101 | S180 | ochoa | Zinc finger protein 101 (Zinc finger protein HZF12) | May be involved in transcriptional regulation. |
| Q8N183 | NDUFAF2 | S134 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8NAP3 | ZBTB38 | S1021 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NDX1 | PSD4 | S131 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFU7 | TET1 | S871 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8WXI9 | GATAD2B | S213 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92585 | MAML1 | S303 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92766 | RREB1 | S1653 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q969S3 | ZNF622 | S78 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96AV8 | E2F7 | S95 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96DF8 | ESS2 | S305 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96I25 | RBM17 | S222 | ochoa|psp | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96JM3 | CHAMP1 | S121 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96S59 | RANBP9 | S176 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96SB4 | SRPK1 | S333 | ochoa | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99798 | ACO2 | S559 | ochoa | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| Q9C040 | TRIM2 | S428 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
| Q9C086 | INO80B | S97 | ochoa | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | Induces growth and cell cycle arrests at the G1 phase of the cell cycle. {ECO:0000269|PubMed:15556297}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000269|PubMed:15556297}. |
| Q9H1H9 | KIF13A | S1460 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H223 | EHD4 | S157 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H4L5 | OSBPL3 | S385 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H694 | BICC1 | S766 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H869 | YY1AP1 | S724 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9HBD1 | RC3H2 | S562 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NQC3 | RTN4 | S739 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQW6 | ANLN | S308 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NUA8 | ZBTB40 | S621 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9P270 | SLAIN2 | S147 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UGU0 | TCF20 | S966 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UKV3 | ACIN1 | S698 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULI3 | HEG1 | S1332 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9ULI3 | HEG1 | S1359 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9ULL1 | PLEKHG1 | S108 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UM01 | SLC7A7 | S25 | ochoa | Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity). {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}. |
| Q9UMZ2 | SYNRG | S1098 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPS6 | SETD1B | S211 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9Y2D8 | SSX2IP | S306 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2K7 | KDM2A | S394 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y4G8 | RAPGEF2 | S498 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y4P1 | ATG4B | S316 | psp | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q9Y6X2 | PIAS3 | S431 | ochoa | E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}. |
| O15075 | DCLK1 | S160 | Sugiyama | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
| O15111 | CHUK | S414 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| Q12851 | MAP4K2 | S475 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q8IVH8 | MAP4K3 | S549 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| P50502 | ST13 | S218 | Sugiyama | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| Q8NFI4 | ST13P5 | S218 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
| Q86Z02 | HIPK1 | S342 | Sugiyama | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q9H2X6 | HIPK2 | S351 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H422 | HIPK3 | S349 | Sugiyama | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.001060 | 2.975 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.023203 | 1.634 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.023203 | 1.634 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.038374 | 1.416 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.117729 | 0.929 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.144945 | 0.839 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.151618 | 0.819 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.043322 | 1.363 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.233805 | 0.631 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.380107 | 0.420 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.233410 | 0.632 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.245728 | 0.610 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.184215 | 0.735 |
| R-HSA-381042 | PERK regulates gene expression | 0.043300 | 1.364 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.117729 | 0.929 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.127598 | 0.894 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.185092 | 0.733 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.022036 | 1.657 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.177797 | 0.750 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.227323 | 0.643 |
| R-HSA-72172 | mRNA Splicing | 0.256286 | 0.591 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.053311 | 1.273 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.360325 | 0.443 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.060693 | 1.217 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.096755 | 1.014 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.350200 | 0.456 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.313496 | 0.504 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.339917 | 0.469 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.144945 | 0.839 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.389769 | 0.409 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.060693 | 1.217 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.082498 | 1.084 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.138220 | 0.859 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.144945 | 0.839 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.196903 | 0.706 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.209396 | 0.679 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.209396 | 0.679 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.269024 | 0.570 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.308087 | 0.511 |
| R-HSA-1538133 | G0 and Early G1 | 0.036162 | 1.442 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.274736 | 0.561 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.110792 | 0.955 |
| R-HSA-9930044 | Nuclear RNA decay | 0.263268 | 0.580 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.263268 | 0.580 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.165206 | 0.782 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.389769 | 0.409 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.221099 | 0.655 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.089654 | 1.047 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.308087 | 0.511 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.308087 | 0.511 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.010969 | 1.960 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.001866 | 2.729 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.138220 | 0.859 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.171328 | 0.766 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.209396 | 0.679 |
| R-HSA-5617833 | Cilium Assembly | 0.225188 | 0.647 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.355282 | 0.449 |
| R-HSA-9609507 | Protein localization | 0.387216 | 0.412 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.009950 | 2.002 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.370293 | 0.431 |
| R-HSA-72312 | rRNA processing | 0.315627 | 0.501 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.097336 | 1.012 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.016711 | 1.777 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.117729 | 0.929 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.117729 | 0.929 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.117729 | 0.929 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.131443 | 0.881 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.144945 | 0.839 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.215569 | 0.666 |
| R-HSA-774815 | Nucleosome assembly | 0.339917 | 0.469 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.339917 | 0.469 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.221585 | 0.654 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.269024 | 0.570 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.280403 | 0.552 |
| R-HSA-5260271 | Diseases of Immune System | 0.308087 | 0.511 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.308087 | 0.511 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.117274 | 0.931 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.060693 | 1.217 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.103801 | 0.984 |
| R-HSA-8851805 | MET activates RAS signaling | 0.117729 | 0.929 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.124613 | 0.904 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 0.131443 | 0.881 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.196903 | 0.706 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.227774 | 0.642 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.269024 | 0.570 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.308087 | 0.511 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.014814 | 1.829 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.151618 | 0.819 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.164809 | 0.783 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.313496 | 0.504 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.345079 | 0.462 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.060693 | 1.217 |
| R-HSA-5578768 | Physiological factors | 0.008976 | 2.047 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.158239 | 0.801 |
| R-HSA-77387 | Insulin receptor recycling | 0.233805 | 0.631 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.324188 | 0.489 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.039136 | 1.407 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.132591 | 0.877 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.367742 | 0.434 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.161545 | 0.792 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.387216 | 0.412 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.339917 | 0.469 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.043300 | 1.364 |
| R-HSA-877300 | Interferon gamma signaling | 0.162058 | 0.790 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.107178 | 0.970 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.274736 | 0.561 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.291606 | 0.535 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.375219 | 0.426 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.128135 | 0.892 |
| R-HSA-3214842 | HDMs demethylate histones | 0.215569 | 0.666 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.334715 | 0.475 |
| R-HSA-69236 | G1 Phase | 0.334715 | 0.475 |
| R-HSA-8953854 | Metabolism of RNA | 0.355093 | 0.450 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.008976 | 2.047 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.117729 | 0.929 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.203174 | 0.692 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.375219 | 0.426 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.082498 | 1.084 |
| R-HSA-210991 | Basigin interactions | 0.184215 | 0.735 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.280403 | 0.552 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.162456 | 0.789 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.308087 | 0.511 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.319895 | 0.495 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.345206 | 0.462 |
| R-HSA-73893 | DNA Damage Bypass | 0.360325 | 0.443 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.177797 | 0.750 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.026429 | 1.578 |
| R-HSA-156588 | Glucuronidation | 0.384957 | 0.415 |
| R-HSA-4839726 | Chromatin organization | 0.351905 | 0.454 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.345079 | 0.462 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.171328 | 0.766 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.263268 | 0.580 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.263268 | 0.580 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.269024 | 0.570 |
| R-HSA-8854214 | TBC/RABGAPs | 0.329472 | 0.482 |
| R-HSA-75893 | TNF signaling | 0.394544 | 0.404 |
| R-HSA-73894 | DNA Repair | 0.178219 | 0.749 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.339917 | 0.469 |
| R-HSA-5576891 | Cardiac conduction | 0.109081 | 0.962 |
| R-HSA-6806834 | Signaling by MET | 0.151544 | 0.819 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.227323 | 0.643 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.394544 | 0.404 |
| R-HSA-5578775 | Ion homeostasis | 0.394544 | 0.404 |
| R-HSA-73887 | Death Receptor Signaling | 0.389977 | 0.409 |
| R-HSA-913531 | Interferon Signaling | 0.210601 | 0.677 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.203174 | 0.692 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.274736 | 0.561 |
| R-HSA-74160 | Gene expression (Transcription) | 0.292296 | 0.534 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.233072 | 0.633 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.036162 | 1.442 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.051915 | 1.285 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.087988 | 1.056 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.259033 | 0.587 |
| R-HSA-212436 | Generic Transcription Pathway | 0.248030 | 0.605 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.285036 | 0.545 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.364624 | 0.438 |
| R-HSA-354192 | Integrin signaling | 0.263268 | 0.580 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.044403 | 1.353 |
| R-HSA-397014 | Muscle contraction | 0.273117 | 0.564 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.339917 | 0.469 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.286026 | 0.544 |
| R-HSA-75153 | Apoptotic execution phase | 0.067424 | 1.171 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.381677 | 0.418 |
| R-HSA-9758941 | Gastrulation | 0.376118 | 0.425 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.389977 | 0.409 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.112196 | 0.950 |
| R-HSA-1632852 | Macroautophagy | 0.350865 | 0.455 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.140789 | 0.851 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.173506 | 0.761 |
| R-HSA-9612973 | Autophagy | 0.395483 | 0.403 |
| R-HSA-9711097 | Cellular response to starvation | 0.400967 | 0.397 |
| R-HSA-9033241 | Peroxisomal protein import | 0.408648 | 0.389 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.408648 | 0.389 |
| R-HSA-186712 | Regulation of beta-cell development | 0.408648 | 0.389 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.408648 | 0.389 |
| R-HSA-109581 | Apoptosis | 0.411865 | 0.385 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.413276 | 0.384 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.413276 | 0.384 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.413276 | 0.384 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.413276 | 0.384 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.413276 | 0.384 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.413276 | 0.384 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.413276 | 0.384 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.413276 | 0.384 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.415261 | 0.382 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.417869 | 0.379 |
| R-HSA-450294 | MAP kinase activation | 0.417869 | 0.379 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.417869 | 0.379 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.422426 | 0.374 |
| R-HSA-1268020 | Mitochondrial protein import | 0.422426 | 0.374 |
| R-HSA-6799198 | Complex I biogenesis | 0.426947 | 0.370 |
| R-HSA-8848021 | Signaling by PTK6 | 0.426947 | 0.370 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.426947 | 0.370 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.431433 | 0.365 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.435990 | 0.361 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.444684 | 0.352 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.449033 | 0.348 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.450341 | 0.346 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.457628 | 0.339 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.457628 | 0.339 |
| R-HSA-448424 | Interleukin-17 signaling | 0.457628 | 0.339 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.457628 | 0.339 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.461876 | 0.335 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.461876 | 0.335 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.470273 | 0.328 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.474423 | 0.324 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.474423 | 0.324 |
| R-HSA-69275 | G2/M Transition | 0.477624 | 0.321 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.478541 | 0.320 |
| R-HSA-8852135 | Protein ubiquitination | 0.478541 | 0.320 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.478541 | 0.320 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.482626 | 0.316 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.482626 | 0.316 |
| R-HSA-5689603 | UCH proteinases | 0.482626 | 0.316 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.482694 | 0.316 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.486680 | 0.313 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.490702 | 0.309 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.498363 | 0.302 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.498652 | 0.302 |
| R-HSA-9833482 | PKR-mediated signaling | 0.498652 | 0.302 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.502581 | 0.299 |
| R-HSA-1640170 | Cell Cycle | 0.508449 | 0.294 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.510348 | 0.292 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.514186 | 0.289 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.517995 | 0.286 |
| R-HSA-5357801 | Programmed Cell Death | 0.526940 | 0.278 |
| R-HSA-70268 | Pyruvate metabolism | 0.529243 | 0.276 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.529243 | 0.276 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.536596 | 0.270 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.538625 | 0.269 |
| R-HSA-202424 | Downstream TCR signaling | 0.540230 | 0.267 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.543836 | 0.265 |
| R-HSA-391251 | Protein folding | 0.550963 | 0.259 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.550963 | 0.259 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.550963 | 0.259 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.557980 | 0.253 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.561448 | 0.251 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.568302 | 0.245 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.568302 | 0.245 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.568302 | 0.245 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.568302 | 0.245 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.571689 | 0.243 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.571689 | 0.243 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.575050 | 0.240 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.575050 | 0.240 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.575050 | 0.240 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.575050 | 0.240 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.578385 | 0.238 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.578385 | 0.238 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.584977 | 0.233 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.588234 | 0.230 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.588234 | 0.230 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.591466 | 0.228 |
| R-HSA-9833110 | RSV-host interactions | 0.597855 | 0.223 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.601012 | 0.221 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.607253 | 0.217 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.610336 | 0.214 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.610336 | 0.214 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.610336 | 0.214 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.613396 | 0.212 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.613396 | 0.212 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.616432 | 0.210 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.616432 | 0.210 |
| R-HSA-202403 | TCR signaling | 0.616432 | 0.210 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.616432 | 0.210 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.625399 | 0.204 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.625399 | 0.204 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.628342 | 0.202 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.634158 | 0.198 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.637032 | 0.196 |
| R-HSA-373760 | L1CAM interactions | 0.639884 | 0.194 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.642714 | 0.192 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.645521 | 0.190 |
| R-HSA-5693538 | Homology Directed Repair | 0.645521 | 0.190 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.648307 | 0.188 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.648307 | 0.188 |
| R-HSA-3371556 | Cellular response to heat stress | 0.653814 | 0.185 |
| R-HSA-73886 | Chromosome Maintenance | 0.653814 | 0.185 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.656535 | 0.183 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.656535 | 0.183 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.659234 | 0.181 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.660956 | 0.180 |
| R-HSA-69206 | G1/S Transition | 0.667208 | 0.176 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.672008 | 0.173 |
| R-HSA-114608 | Platelet degranulation | 0.672421 | 0.172 |
| R-HSA-69481 | G2/M Checkpoints | 0.672421 | 0.172 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.677998 | 0.169 |
| R-HSA-446728 | Cell junction organization | 0.679214 | 0.168 |
| R-HSA-9843745 | Adipogenesis | 0.685101 | 0.164 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.687578 | 0.163 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.690035 | 0.161 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.702039 | 0.154 |
| R-HSA-5368287 | Mitochondrial translation | 0.704383 | 0.152 |
| R-HSA-6807070 | PTEN Regulation | 0.706710 | 0.151 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.708422 | 0.150 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.715835 | 0.145 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.720292 | 0.142 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.726847 | 0.139 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.728998 | 0.137 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.733250 | 0.135 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.737435 | 0.132 |
| R-HSA-1500931 | Cell-Cell communication | 0.741431 | 0.130 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.741556 | 0.130 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.749605 | 0.125 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.753536 | 0.123 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.760428 | 0.119 |
| R-HSA-5619102 | SLC transporter disorders | 0.766818 | 0.115 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.775868 | 0.110 |
| R-HSA-418555 | G alpha (s) signalling events | 0.775868 | 0.110 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.777864 | 0.109 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.786881 | 0.104 |
| R-HSA-611105 | Respiratory electron transport | 0.787955 | 0.103 |
| R-HSA-2559583 | Cellular Senescence | 0.791289 | 0.102 |
| R-HSA-983712 | Ion channel transport | 0.805656 | 0.094 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.808713 | 0.092 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.814430 | 0.089 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.821890 | 0.085 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.824693 | 0.084 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.826079 | 0.083 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.826079 | 0.083 |
| R-HSA-9679506 | SARS-CoV Infections | 0.832289 | 0.080 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.858521 | 0.066 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.868290 | 0.061 |
| R-HSA-72766 | Translation | 0.870013 | 0.060 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.870368 | 0.060 |
| R-HSA-157118 | Signaling by NOTCH | 0.871395 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.878360 | 0.056 |
| R-HSA-449147 | Signaling by Interleukins | 0.884918 | 0.053 |
| R-HSA-5688426 | Deubiquitination | 0.885863 | 0.053 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.888557 | 0.051 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.904972 | 0.043 |
| R-HSA-2262752 | Cellular responses to stress | 0.914780 | 0.039 |
| R-HSA-1483257 | Phospholipid metabolism | 0.917022 | 0.038 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.925015 | 0.034 |
| R-HSA-211859 | Biological oxidations | 0.928835 | 0.032 |
| R-HSA-162582 | Signal Transduction | 0.930072 | 0.031 |
| R-HSA-8957322 | Metabolism of steroids | 0.934180 | 0.030 |
| R-HSA-109582 | Hemostasis | 0.954018 | 0.020 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.959298 | 0.018 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.960929 | 0.017 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.963626 | 0.016 |
| R-HSA-199991 | Membrane Trafficking | 0.969213 | 0.014 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.970249 | 0.013 |
| R-HSA-112316 | Neuronal System | 0.979463 | 0.009 |
| R-HSA-597592 | Post-translational protein modification | 0.981287 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 0.981671 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 0.986565 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 0.987807 | 0.005 |
| R-HSA-422475 | Axon guidance | 0.988984 | 0.005 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.989953 | 0.004 |
| R-HSA-9675108 | Nervous system development | 0.991843 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 0.998304 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999145 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999523 | 0.000 |
| R-HSA-1266738 | Developmental Biology | 0.999646 | 0.000 |
| R-HSA-1280218 | Adaptive Immune System | 0.999823 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999942 | 0.000 |
| R-HSA-168256 | Immune System | 0.999980 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999984 | 0.000 |
| R-HSA-1643685 | Disease | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.850 | 0.699 | 1 | 0.942 |
DYRK2 |
0.850 | 0.665 | 1 | 0.926 |
KIS |
0.850 | 0.641 | 1 | 0.941 |
CDK19 |
0.850 | 0.679 | 1 | 0.930 |
HIPK2 |
0.849 | 0.668 | 1 | 0.942 |
CDK8 |
0.848 | 0.675 | 1 | 0.927 |
JNK2 |
0.847 | 0.746 | 1 | 0.941 |
HIPK4 |
0.847 | 0.475 | 1 | 0.840 |
P38G |
0.845 | 0.728 | 1 | 0.934 |
CDK17 |
0.844 | 0.702 | 1 | 0.930 |
CDK7 |
0.844 | 0.665 | 1 | 0.937 |
CLK3 |
0.843 | 0.457 | 1 | 0.819 |
DYRK4 |
0.841 | 0.666 | 1 | 0.945 |
P38D |
0.841 | 0.727 | 1 | 0.935 |
P38B |
0.840 | 0.703 | 1 | 0.941 |
P38A |
0.839 | 0.687 | 1 | 0.932 |
DYRK1B |
0.839 | 0.647 | 1 | 0.937 |
HIPK1 |
0.839 | 0.619 | 1 | 0.924 |
JNK3 |
0.839 | 0.721 | 1 | 0.945 |
ERK1 |
0.838 | 0.679 | 1 | 0.945 |
CDK13 |
0.837 | 0.662 | 1 | 0.945 |
CDK12 |
0.835 | 0.667 | 1 | 0.949 |
DYRK1A |
0.835 | 0.540 | 1 | 0.926 |
CDK16 |
0.835 | 0.672 | 1 | 0.931 |
CDK5 |
0.835 | 0.639 | 1 | 0.929 |
CDK1 |
0.834 | 0.652 | 1 | 0.936 |
CDK9 |
0.833 | 0.661 | 1 | 0.946 |
CDK14 |
0.833 | 0.671 | 1 | 0.937 |
CDK3 |
0.832 | 0.607 | 1 | 0.931 |
SRPK1 |
0.832 | 0.300 | -3 | 0.690 |
HIPK3 |
0.832 | 0.601 | 1 | 0.910 |
NLK |
0.831 | 0.577 | 1 | 0.838 |
CLK1 |
0.830 | 0.401 | -3 | 0.707 |
ERK2 |
0.828 | 0.661 | 1 | 0.954 |
DYRK3 |
0.828 | 0.503 | 1 | 0.901 |
ERK5 |
0.826 | 0.350 | 1 | 0.768 |
CLK4 |
0.826 | 0.371 | -3 | 0.722 |
SRPK2 |
0.823 | 0.241 | -3 | 0.617 |
CDK10 |
0.822 | 0.614 | 1 | 0.940 |
CLK2 |
0.821 | 0.379 | -3 | 0.710 |
PRKD1 |
0.820 | 0.091 | -3 | 0.788 |
CDK4 |
0.819 | 0.650 | 1 | 0.950 |
MTOR |
0.818 | 0.145 | 1 | 0.671 |
ICK |
0.818 | 0.304 | -3 | 0.776 |
COT |
0.817 | -0.047 | 2 | 0.820 |
JNK1 |
0.816 | 0.637 | 1 | 0.932 |
PRKD2 |
0.816 | 0.089 | -3 | 0.743 |
CDK2 |
0.816 | 0.492 | 1 | 0.893 |
CDKL5 |
0.814 | 0.141 | -3 | 0.736 |
TSSK1 |
0.814 | 0.111 | -3 | 0.848 |
CDK6 |
0.813 | 0.615 | 1 | 0.938 |
SRPK3 |
0.812 | 0.207 | -3 | 0.652 |
CDKL1 |
0.812 | 0.109 | -3 | 0.738 |
NUAK2 |
0.812 | 0.070 | -3 | 0.801 |
CAMK1B |
0.811 | 0.036 | -3 | 0.809 |
TBK1 |
0.810 | -0.087 | 1 | 0.483 |
NDR2 |
0.810 | 0.002 | -3 | 0.804 |
PRP4 |
0.810 | 0.429 | -3 | 0.739 |
MAK |
0.809 | 0.432 | -2 | 0.715 |
WNK1 |
0.809 | 0.004 | -2 | 0.809 |
NEK6 |
0.809 | -0.002 | -2 | 0.830 |
CDC7 |
0.809 | -0.083 | 1 | 0.501 |
P90RSK |
0.808 | 0.033 | -3 | 0.727 |
RSK3 |
0.808 | 0.028 | -3 | 0.724 |
PRPK |
0.807 | -0.105 | -1 | 0.804 |
SKMLCK |
0.807 | 0.039 | -2 | 0.818 |
GCN2 |
0.807 | -0.139 | 2 | 0.739 |
AMPKA1 |
0.807 | 0.043 | -3 | 0.821 |
AURC |
0.807 | 0.098 | -2 | 0.665 |
RSK2 |
0.807 | 0.037 | -3 | 0.730 |
CAMLCK |
0.806 | 0.063 | -2 | 0.825 |
RAF1 |
0.806 | -0.129 | 1 | 0.540 |
PRKD3 |
0.805 | 0.064 | -3 | 0.705 |
TGFBR2 |
0.805 | -0.006 | -2 | 0.808 |
NDR1 |
0.805 | -0.009 | -3 | 0.794 |
IKKE |
0.805 | -0.117 | 1 | 0.483 |
AMPKA2 |
0.805 | 0.050 | -3 | 0.791 |
TSSK2 |
0.804 | 0.049 | -5 | 0.846 |
MNK2 |
0.804 | 0.066 | -2 | 0.771 |
NUAK1 |
0.804 | 0.033 | -3 | 0.756 |
PAK6 |
0.803 | 0.090 | -2 | 0.716 |
MOK |
0.803 | 0.408 | 1 | 0.865 |
MOS |
0.803 | -0.057 | 1 | 0.566 |
PIM3 |
0.803 | -0.039 | -3 | 0.788 |
PDHK4 |
0.803 | -0.180 | 1 | 0.604 |
NIK |
0.803 | 0.004 | -3 | 0.830 |
BMPR2 |
0.802 | -0.111 | -2 | 0.841 |
MARK4 |
0.802 | 0.012 | 4 | 0.843 |
PKN3 |
0.802 | -0.032 | -3 | 0.782 |
MELK |
0.802 | 0.030 | -3 | 0.780 |
HUNK |
0.802 | -0.066 | 2 | 0.804 |
ATR |
0.802 | -0.041 | 1 | 0.584 |
MAPKAPK3 |
0.801 | -0.004 | -3 | 0.745 |
ULK2 |
0.801 | -0.172 | 2 | 0.732 |
DSTYK |
0.800 | -0.112 | 2 | 0.801 |
P70S6KB |
0.799 | 0.024 | -3 | 0.753 |
IRE1 |
0.799 | -0.047 | 1 | 0.573 |
PKCD |
0.799 | -0.003 | 2 | 0.689 |
NEK7 |
0.799 | -0.127 | -3 | 0.770 |
PKACG |
0.799 | 0.013 | -2 | 0.716 |
PDHK1 |
0.798 | -0.157 | 1 | 0.583 |
DAPK2 |
0.798 | 0.007 | -3 | 0.818 |
CHAK2 |
0.798 | -0.048 | -1 | 0.828 |
NIM1 |
0.798 | -0.027 | 3 | 0.805 |
LATS2 |
0.798 | -0.029 | -5 | 0.720 |
PKN2 |
0.797 | -0.042 | -3 | 0.792 |
RIPK3 |
0.797 | -0.117 | 3 | 0.782 |
MST4 |
0.797 | -0.041 | 2 | 0.773 |
IKKB |
0.796 | -0.189 | -2 | 0.708 |
PAK3 |
0.796 | 0.000 | -2 | 0.765 |
PIM1 |
0.795 | 0.019 | -3 | 0.733 |
QSK |
0.795 | 0.039 | 4 | 0.830 |
MNK1 |
0.795 | 0.051 | -2 | 0.782 |
PAK1 |
0.794 | 0.012 | -2 | 0.764 |
WNK3 |
0.794 | -0.171 | 1 | 0.561 |
AKT2 |
0.794 | 0.063 | -3 | 0.650 |
PKACB |
0.793 | 0.068 | -2 | 0.673 |
AURB |
0.793 | 0.056 | -2 | 0.661 |
MAPKAPK2 |
0.793 | -0.007 | -3 | 0.691 |
IRE2 |
0.793 | -0.050 | 2 | 0.696 |
ULK1 |
0.792 | -0.165 | -3 | 0.741 |
SIK |
0.792 | 0.021 | -3 | 0.725 |
CHK1 |
0.792 | 0.024 | -3 | 0.811 |
NEK9 |
0.792 | -0.145 | 2 | 0.772 |
CAMK2D |
0.792 | -0.079 | -3 | 0.800 |
IKKA |
0.792 | -0.095 | -2 | 0.693 |
SGK3 |
0.791 | 0.037 | -3 | 0.734 |
PKG2 |
0.791 | 0.045 | -2 | 0.671 |
CAMK4 |
0.791 | -0.056 | -3 | 0.784 |
QIK |
0.791 | -0.039 | -3 | 0.799 |
BRSK2 |
0.790 | -0.017 | -3 | 0.788 |
LATS1 |
0.790 | 0.020 | -3 | 0.816 |
CAMK2G |
0.790 | -0.157 | 2 | 0.747 |
PHKG1 |
0.790 | -0.047 | -3 | 0.789 |
MLK2 |
0.790 | -0.114 | 2 | 0.730 |
MLK1 |
0.789 | -0.187 | 2 | 0.726 |
MASTL |
0.788 | -0.196 | -2 | 0.754 |
MSK2 |
0.788 | -0.029 | -3 | 0.682 |
PKCB |
0.788 | -0.031 | 2 | 0.634 |
RIPK1 |
0.788 | -0.181 | 1 | 0.557 |
RSK4 |
0.788 | 0.018 | -3 | 0.702 |
MARK3 |
0.788 | 0.040 | 4 | 0.798 |
GRK5 |
0.787 | -0.186 | -3 | 0.796 |
BRSK1 |
0.787 | -0.018 | -3 | 0.759 |
PKCZ |
0.787 | -0.032 | 2 | 0.693 |
DNAPK |
0.787 | -0.022 | 1 | 0.523 |
PKCA |
0.786 | -0.032 | 2 | 0.625 |
DCAMKL1 |
0.786 | 0.015 | -3 | 0.764 |
PKR |
0.786 | -0.048 | 1 | 0.593 |
MYLK4 |
0.786 | 0.011 | -2 | 0.760 |
MSK1 |
0.786 | 0.007 | -3 | 0.696 |
BCKDK |
0.786 | -0.193 | -1 | 0.736 |
ALK4 |
0.785 | -0.037 | -2 | 0.793 |
MLK3 |
0.785 | -0.087 | 2 | 0.632 |
PAK2 |
0.785 | -0.022 | -2 | 0.750 |
ERK7 |
0.785 | 0.187 | 2 | 0.434 |
VRK2 |
0.785 | 0.022 | 1 | 0.641 |
PRKX |
0.785 | 0.063 | -3 | 0.663 |
NEK2 |
0.785 | -0.100 | 2 | 0.732 |
ATM |
0.784 | -0.079 | 1 | 0.518 |
SSTK |
0.784 | 0.048 | 4 | 0.819 |
MARK2 |
0.784 | 0.017 | 4 | 0.758 |
AKT1 |
0.784 | 0.050 | -3 | 0.675 |
CAMK1G |
0.784 | -0.011 | -3 | 0.710 |
ANKRD3 |
0.784 | -0.179 | 1 | 0.569 |
MPSK1 |
0.783 | 0.064 | 1 | 0.581 |
PKCG |
0.783 | -0.060 | 2 | 0.633 |
TGFBR1 |
0.783 | -0.034 | -2 | 0.766 |
PAK5 |
0.783 | 0.041 | -2 | 0.645 |
TLK2 |
0.782 | -0.061 | 1 | 0.539 |
PLK1 |
0.782 | -0.090 | -2 | 0.808 |
BUB1 |
0.782 | 0.147 | -5 | 0.863 |
PIM2 |
0.782 | 0.023 | -3 | 0.708 |
PKACA |
0.782 | 0.052 | -2 | 0.637 |
BMPR1B |
0.781 | -0.025 | 1 | 0.448 |
AURA |
0.781 | 0.024 | -2 | 0.644 |
PINK1 |
0.781 | 0.079 | 1 | 0.722 |
WNK4 |
0.781 | -0.060 | -2 | 0.792 |
PKCH |
0.781 | -0.065 | 2 | 0.634 |
PLK4 |
0.781 | -0.079 | 2 | 0.623 |
PERK |
0.781 | -0.058 | -2 | 0.838 |
PAK4 |
0.780 | 0.048 | -2 | 0.655 |
CAMK2A |
0.780 | -0.045 | 2 | 0.720 |
CHAK1 |
0.780 | -0.140 | 2 | 0.688 |
HRI |
0.780 | -0.092 | -2 | 0.850 |
DCAMKL2 |
0.780 | -0.012 | -3 | 0.782 |
TTBK2 |
0.779 | -0.206 | 2 | 0.654 |
GRK4 |
0.779 | -0.179 | -2 | 0.765 |
IRAK4 |
0.779 | -0.074 | 1 | 0.559 |
MARK1 |
0.778 | -0.016 | 4 | 0.807 |
DLK |
0.778 | -0.273 | 1 | 0.548 |
MAPKAPK5 |
0.778 | -0.090 | -3 | 0.665 |
PKCT |
0.777 | -0.039 | 2 | 0.641 |
SNRK |
0.777 | -0.137 | 2 | 0.638 |
CAMK2B |
0.777 | -0.083 | 2 | 0.718 |
NEK5 |
0.777 | -0.078 | 1 | 0.564 |
SMG1 |
0.777 | -0.099 | 1 | 0.556 |
P70S6K |
0.776 | -0.006 | -3 | 0.663 |
PHKG2 |
0.776 | -0.052 | -3 | 0.769 |
ACVR2A |
0.776 | -0.041 | -2 | 0.811 |
GRK6 |
0.776 | -0.193 | 1 | 0.516 |
CAMK1D |
0.776 | 0.014 | -3 | 0.667 |
YSK4 |
0.776 | -0.171 | 1 | 0.511 |
GRK1 |
0.776 | -0.123 | -2 | 0.712 |
ACVR2B |
0.775 | -0.050 | -2 | 0.813 |
MEK1 |
0.775 | -0.176 | 2 | 0.778 |
AKT3 |
0.774 | 0.052 | -3 | 0.585 |
PLK3 |
0.774 | -0.105 | 2 | 0.730 |
SMMLCK |
0.774 | -0.007 | -3 | 0.763 |
TLK1 |
0.774 | -0.087 | -2 | 0.798 |
PKCI |
0.773 | -0.020 | 2 | 0.657 |
GRK7 |
0.773 | -0.048 | 1 | 0.521 |
FAM20C |
0.773 | -0.047 | 2 | 0.550 |
LKB1 |
0.773 | 0.028 | -3 | 0.797 |
MLK4 |
0.772 | -0.152 | 2 | 0.622 |
GSK3A |
0.772 | 0.123 | 4 | 0.379 |
SBK |
0.772 | 0.111 | -3 | 0.535 |
MEKK1 |
0.771 | -0.157 | 1 | 0.546 |
PKN1 |
0.771 | -0.014 | -3 | 0.689 |
BRAF |
0.771 | -0.110 | -4 | 0.786 |
MEKK2 |
0.770 | -0.119 | 2 | 0.734 |
MEK5 |
0.770 | -0.186 | 2 | 0.755 |
CAMK1A |
0.770 | 0.037 | -3 | 0.610 |
SGK1 |
0.769 | 0.048 | -3 | 0.569 |
ALK2 |
0.768 | -0.087 | -2 | 0.768 |
MST3 |
0.768 | -0.079 | 2 | 0.754 |
CHK2 |
0.767 | 0.007 | -3 | 0.600 |
TAO3 |
0.767 | -0.074 | 1 | 0.564 |
ZAK |
0.766 | -0.189 | 1 | 0.520 |
PKCE |
0.766 | -0.008 | 2 | 0.624 |
PDK1 |
0.765 | -0.057 | 1 | 0.570 |
MRCKB |
0.765 | 0.043 | -3 | 0.702 |
ROCK2 |
0.764 | 0.053 | -3 | 0.757 |
NEK4 |
0.764 | -0.099 | 1 | 0.546 |
MRCKA |
0.764 | 0.029 | -3 | 0.719 |
DRAK1 |
0.763 | -0.165 | 1 | 0.463 |
IRAK1 |
0.763 | -0.185 | -1 | 0.727 |
LOK |
0.763 | -0.030 | -2 | 0.746 |
GSK3B |
0.763 | -0.001 | 4 | 0.373 |
NEK1 |
0.763 | -0.057 | 1 | 0.550 |
DAPK3 |
0.763 | -0.002 | -3 | 0.755 |
PASK |
0.762 | -0.074 | -3 | 0.794 |
MEKK3 |
0.762 | -0.228 | 1 | 0.540 |
NEK8 |
0.762 | -0.154 | 2 | 0.744 |
TAO2 |
0.761 | -0.089 | 2 | 0.762 |
TNIK |
0.761 | -0.031 | 3 | 0.853 |
GRK2 |
0.761 | -0.132 | -2 | 0.651 |
BMPR1A |
0.761 | -0.059 | 1 | 0.421 |
MEKK6 |
0.761 | -0.081 | 1 | 0.555 |
CAMKK2 |
0.761 | -0.091 | -2 | 0.723 |
PKG1 |
0.760 | 0.016 | -2 | 0.601 |
PBK |
0.760 | 0.001 | 1 | 0.519 |
HASPIN |
0.760 | 0.050 | -1 | 0.706 |
CRIK |
0.760 | 0.065 | -3 | 0.667 |
NEK11 |
0.759 | -0.171 | 1 | 0.551 |
DMPK1 |
0.759 | 0.083 | -3 | 0.721 |
LRRK2 |
0.759 | -0.044 | 2 | 0.777 |
CAMKK1 |
0.758 | -0.172 | -2 | 0.713 |
HGK |
0.758 | -0.083 | 3 | 0.855 |
GAK |
0.758 | -0.064 | 1 | 0.570 |
GCK |
0.756 | -0.094 | 1 | 0.542 |
MAP3K15 |
0.756 | -0.118 | 1 | 0.529 |
NEK3 |
0.756 | -0.068 | 1 | 0.543 |
CK1E |
0.755 | -0.101 | -3 | 0.460 |
TTBK1 |
0.754 | -0.196 | 2 | 0.583 |
KHS1 |
0.753 | -0.047 | 1 | 0.544 |
DAPK1 |
0.753 | -0.024 | -3 | 0.730 |
MINK |
0.752 | -0.133 | 1 | 0.535 |
VRK1 |
0.752 | -0.141 | 2 | 0.821 |
ROCK1 |
0.752 | 0.034 | -3 | 0.720 |
HPK1 |
0.751 | -0.093 | 1 | 0.542 |
EEF2K |
0.751 | -0.113 | 3 | 0.781 |
SLK |
0.751 | -0.083 | -2 | 0.688 |
KHS2 |
0.749 | -0.044 | 1 | 0.557 |
CK1G1 |
0.748 | -0.121 | -3 | 0.442 |
YSK1 |
0.747 | -0.121 | 2 | 0.729 |
MST2 |
0.747 | -0.174 | 1 | 0.524 |
MST1 |
0.747 | -0.143 | 1 | 0.530 |
CK1D |
0.747 | -0.081 | -3 | 0.406 |
MEK2 |
0.747 | -0.179 | 2 | 0.758 |
STK33 |
0.746 | -0.151 | 2 | 0.562 |
BIKE |
0.746 | -0.009 | 1 | 0.490 |
TTK |
0.745 | -0.010 | -2 | 0.823 |
CK1A2 |
0.744 | -0.093 | -3 | 0.407 |
LIMK2_TYR |
0.744 | 0.177 | -3 | 0.853 |
PLK2 |
0.744 | -0.084 | -3 | 0.721 |
PDHK3_TYR |
0.744 | 0.135 | 4 | 0.851 |
AAK1 |
0.742 | 0.034 | 1 | 0.445 |
TAK1 |
0.742 | -0.225 | 1 | 0.529 |
GRK3 |
0.742 | -0.145 | -2 | 0.603 |
RIPK2 |
0.742 | -0.236 | 1 | 0.481 |
MYO3B |
0.742 | -0.058 | 2 | 0.730 |
TAO1 |
0.739 | -0.092 | 1 | 0.517 |
TESK1_TYR |
0.737 | 0.028 | 3 | 0.887 |
PKMYT1_TYR |
0.736 | 0.069 | 3 | 0.869 |
OSR1 |
0.735 | -0.106 | 2 | 0.723 |
ASK1 |
0.734 | -0.135 | 1 | 0.516 |
MYO3A |
0.732 | -0.115 | 1 | 0.565 |
MAP2K4_TYR |
0.731 | -0.037 | -1 | 0.801 |
CK2A2 |
0.731 | -0.133 | 1 | 0.380 |
PDHK4_TYR |
0.730 | -0.019 | 2 | 0.807 |
RET |
0.730 | -0.085 | 1 | 0.574 |
TNK1 |
0.730 | 0.020 | 3 | 0.823 |
MAP2K7_TYR |
0.729 | -0.136 | 2 | 0.796 |
LIMK1_TYR |
0.729 | -0.013 | 2 | 0.783 |
MAP2K6_TYR |
0.728 | -0.051 | -1 | 0.810 |
MST1R |
0.727 | -0.076 | 3 | 0.846 |
JAK2 |
0.727 | -0.068 | 1 | 0.571 |
PINK1_TYR |
0.726 | -0.170 | 1 | 0.598 |
ALPHAK3 |
0.726 | -0.105 | -1 | 0.710 |
DDR1 |
0.725 | -0.081 | 4 | 0.806 |
CSF1R |
0.725 | -0.068 | 3 | 0.827 |
TNNI3K_TYR |
0.724 | 0.013 | 1 | 0.577 |
BMPR2_TYR |
0.724 | -0.073 | -1 | 0.763 |
ABL2 |
0.724 | -0.045 | -1 | 0.725 |
ROS1 |
0.724 | -0.105 | 3 | 0.805 |
TYK2 |
0.724 | -0.167 | 1 | 0.558 |
TYRO3 |
0.722 | -0.127 | 3 | 0.832 |
PDHK1_TYR |
0.722 | -0.137 | -1 | 0.800 |
NEK10_TYR |
0.721 | -0.062 | 1 | 0.516 |
CK2A1 |
0.720 | -0.146 | 1 | 0.367 |
ABL1 |
0.720 | -0.060 | -1 | 0.720 |
YANK3 |
0.718 | -0.104 | 2 | 0.369 |
EPHA6 |
0.718 | -0.111 | -1 | 0.728 |
TNK2 |
0.717 | -0.082 | 3 | 0.809 |
EPHB4 |
0.717 | -0.116 | -1 | 0.707 |
FGFR2 |
0.717 | -0.064 | 3 | 0.810 |
JAK1 |
0.716 | -0.075 | 1 | 0.517 |
FGFR1 |
0.716 | -0.053 | 3 | 0.793 |
STLK3 |
0.715 | -0.207 | 1 | 0.498 |
JAK3 |
0.715 | -0.152 | 1 | 0.546 |
FGR |
0.714 | -0.141 | 1 | 0.529 |
KDR |
0.714 | -0.091 | 3 | 0.789 |
TEK |
0.714 | -0.044 | 3 | 0.772 |
DDR2 |
0.714 | -0.007 | 3 | 0.757 |
PDGFRB |
0.712 | -0.185 | 3 | 0.837 |
KIT |
0.711 | -0.132 | 3 | 0.827 |
YES1 |
0.711 | -0.127 | -1 | 0.726 |
FLT3 |
0.711 | -0.166 | 3 | 0.824 |
AXL |
0.710 | -0.141 | 3 | 0.817 |
INSRR |
0.710 | -0.155 | 3 | 0.776 |
FER |
0.709 | -0.196 | 1 | 0.520 |
TXK |
0.708 | -0.096 | 1 | 0.467 |
MET |
0.706 | -0.124 | 3 | 0.837 |
MERTK |
0.706 | -0.143 | 3 | 0.815 |
PDGFRA |
0.706 | -0.207 | 3 | 0.830 |
EPHA4 |
0.706 | -0.120 | 2 | 0.728 |
ITK |
0.705 | -0.157 | -1 | 0.685 |
HCK |
0.704 | -0.181 | -1 | 0.690 |
EPHB1 |
0.704 | -0.185 | 1 | 0.493 |
LCK |
0.704 | -0.128 | -1 | 0.694 |
WEE1_TYR |
0.704 | -0.114 | -1 | 0.698 |
SRMS |
0.703 | -0.190 | 1 | 0.489 |
FGFR3 |
0.703 | -0.102 | 3 | 0.787 |
EPHB3 |
0.702 | -0.177 | -1 | 0.687 |
ALK |
0.701 | -0.167 | 3 | 0.748 |
CK1A |
0.701 | -0.131 | -3 | 0.316 |
BLK |
0.701 | -0.111 | -1 | 0.686 |
EPHB2 |
0.700 | -0.162 | -1 | 0.677 |
LTK |
0.698 | -0.176 | 3 | 0.768 |
FLT4 |
0.697 | -0.176 | 3 | 0.773 |
BTK |
0.697 | -0.243 | -1 | 0.660 |
INSR |
0.697 | -0.174 | 3 | 0.768 |
EPHA1 |
0.697 | -0.166 | 3 | 0.813 |
BMX |
0.696 | -0.141 | -1 | 0.592 |
FLT1 |
0.696 | -0.172 | -1 | 0.731 |
PTK2B |
0.696 | -0.105 | -1 | 0.676 |
TEC |
0.696 | -0.183 | -1 | 0.609 |
MATK |
0.695 | -0.121 | -1 | 0.681 |
PTK6 |
0.695 | -0.223 | -1 | 0.675 |
ERBB2 |
0.695 | -0.194 | 1 | 0.508 |
NTRK1 |
0.695 | -0.235 | -1 | 0.731 |
NTRK2 |
0.695 | -0.222 | 3 | 0.783 |
FRK |
0.694 | -0.174 | -1 | 0.697 |
NTRK3 |
0.694 | -0.159 | -1 | 0.692 |
EPHA7 |
0.693 | -0.170 | 2 | 0.725 |
CSK |
0.692 | -0.156 | 2 | 0.730 |
EPHA3 |
0.691 | -0.184 | 2 | 0.701 |
FYN |
0.690 | -0.138 | -1 | 0.652 |
LYN |
0.689 | -0.179 | 3 | 0.748 |
FGFR4 |
0.688 | -0.127 | -1 | 0.681 |
EGFR |
0.686 | -0.136 | 1 | 0.441 |
MUSK |
0.686 | -0.144 | 1 | 0.441 |
EPHA8 |
0.683 | -0.165 | -1 | 0.655 |
EPHA5 |
0.683 | -0.186 | 2 | 0.713 |
SRC |
0.683 | -0.168 | -1 | 0.659 |
YANK2 |
0.682 | -0.134 | 2 | 0.372 |
IGF1R |
0.681 | -0.163 | 3 | 0.708 |
CK1G3 |
0.678 | -0.142 | -3 | 0.268 |
PTK2 |
0.678 | -0.117 | -1 | 0.630 |
EPHA2 |
0.676 | -0.162 | -1 | 0.623 |
ERBB4 |
0.671 | -0.137 | 1 | 0.424 |
SYK |
0.671 | -0.151 | -1 | 0.638 |
FES |
0.662 | -0.192 | -1 | 0.588 |
ZAP70 |
0.661 | -0.101 | -1 | 0.594 |
CK1G2 |
0.657 | -0.149 | -3 | 0.360 |