Motif 247 (n=174)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S810 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E9PCH4 | None | Y1300 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| H0YIS7 | RNASEK-C17orf49 | S182 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| H0YIS7 | RNASEK-C17orf49 | S187 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O14976 | GAK | S783 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15516 | CLOCK | S408 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43182 | ARHGAP6 | S680 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O60239 | SH3BP5 | S356 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60825 | PFKFB2 | S471 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O75581 | LRP6 | S1544 | ochoa|psp | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
| O75582 | RPS6KA5 | S381 | ochoa|psp | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| O75676 | RPS6KA4 | S365 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O76080 | ZFAND5 | S61 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94804 | STK10 | S374 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O95613 | PCNT | S3287 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95613 | PCNT | S3292 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P02545 | LMNA | S403 | ochoa|psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P04637 | TP53 | S20 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P04637 | TP53 | S371 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P04792 | HSPB1 | S26 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04792 | HSPB1 | S83 | ochoa|psp | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05549 | TFAP2A | S219 | psp | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P10275 | AR | S293 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P14618 | PKM | S420 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P17096 | HMGA1 | S49 | ochoa|psp | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| P18206 | VCL | S439 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18206 | VCL | S579 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P21333 | FLNA | S2163 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2531 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21860 | ERBB3 | S1315 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P30414 | NKTR | S325 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P33076 | CIITA | S293 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P42696 | RBM34 | Y33 | ochoa | RNA-binding protein 34 (RNA-binding motif protein 34) | None |
| P46108 | CRK | S96 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46934 | NEDD4 | S747 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P48634 | PRRC2A | S1115 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49450 | CENPA | S32 | ochoa | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}. |
| P49792 | RANBP2 | S809 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50402 | EMD | S62 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50748 | KNTC1 | S1050 | ochoa | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| P60709 | ACTB | S344 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P63261 | ACTG1 | S344 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P98175 | RBM10 | S492 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q03164 | KMT2A | S523 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S334 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12802 | AKAP13 | S1900 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | S899 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13164 | MAPK7 | S567 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q13177 | PAK2 | S197 | ochoa|psp | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13322 | GRB10 | S431 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13415 | ORC1 | S350 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q13464 | ROCK1 | S1333 | psp | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13541 | EIF4EBP1 | S96 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13873 | BMPR2 | S944 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q13884 | SNTB1 | S232 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q13905 | RAPGEF1 | S358 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14134 | TRIM29 | S26 | ochoa | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}. |
| Q14151 | SAFB2 | S287 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14155 | ARHGEF7 | S161 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14641 | INSL4 | S103 | ochoa | Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain] | May play an important role in trophoblast development and in the regulation of bone formation. |
| Q14678 | KANK1 | S330 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14684 | RRP1B | S458 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14689 | DIP2A | S145 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q14999 | CUL7 | S1128 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q15036 | SNX17 | S434 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15424 | SAFB | S288 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15678 | PTPN14 | S531 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15699 | ALX1 | S74 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q15911 | ZFHX3 | S431 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16799 | RTN1 | S335 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2LD37 | BLTP1 | S2300 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2NKX8 | ERCC6L | S1082 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q5HYJ3 | FAM76B | S232 | ochoa | Protein FAM76B | Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}. |
| Q5SW79 | CEP170 | S866 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T0W9 | FAM83B | S920 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5VWN6 | TASOR2 | S1722 | ochoa | Protein TASOR 2 | None |
| Q641Q2 | WASHC2A | S996 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S1001 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S1119 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q659C4 | LARP1B | S348 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q66K74 | MAP1S | S651 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6ZSS7 | MFSD6 | S766 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
| Q7L2J0 | MEPCE | S358 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z3J3 | RGPD4 | S810 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5J4 | RAI1 | S642 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6I6 | ARHGAP30 | S835 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6Z7 | HUWE1 | S2931 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3132 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S3560 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86YD5 | LDLRAD3 | S304 | ochoa | Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3) | May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}. |
| Q8IVT2 | MISP | S479 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IX21 | SLF2 | S573 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IXM2 | BACC1 | S141 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IXM2 | BACC1 | S146 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IY22 | CMIP | S382 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8IY33 | MICALL2 | S318 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IZN3 | ZDHHC14 | S460 | ochoa | Palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling (PubMed:27481942). May play a role in cell differentiation and apoptosis (PubMed:21151021, PubMed:24407904). {ECO:0000269|PubMed:21151021, ECO:0000269|PubMed:24407904, ECO:0000269|PubMed:27481942}. |
| Q8N1I0 | DOCK4 | S1769 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N2M8 | CLASRP | S106 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S585 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S895 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N6T3 | ARFGAP1 | S155 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NC44 | RETREG2 | S145 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
| Q8ND30 | PPFIBP2 | S454 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8NHV4 | NEDD1 | S565 | ochoa|psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TC05 | MDM1 | S642 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TEU7 | RAPGEF6 | Y1250 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WYP5 | AHCTF1 | S1155 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92619 | ARHGAP45 | S582 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92633 | LPAR1 | S346 | ochoa | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) | Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}. |
| Q96A57 | TMEM230 | S20 | ochoa | Transmembrane protein 230 | Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}. |
| Q96I25 | RBM17 | S227 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96JM2 | ZNF462 | S701 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96JY6 | PDLIM2 | S142 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96MG2 | JSRP1 | S51 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96S38 | RPS6KC1 | S596 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S38 | RPS6KC1 | S648 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99569 | PKP4 | S132 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99638 | RAD9A | S368 | ochoa | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}. |
| Q99700 | ATXN2 | S642 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BRD0 | BUD13 | S240 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTE3 | MCMBP | S167 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BX66 | SORBS1 | S151 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXB4 | OSBPL11 | S194 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9BXI6 | TBC1D10A | S25 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9H1B7 | IRF2BPL | S220 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H3P2 | NELFA | S230 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H3Q1 | CDC42EP4 | S77 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4L5 | OSBPL3 | S309 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H7E2 | TDRD3 | S345 | ochoa | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9HCS5 | EPB41L4A | S611 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NPB6 | PARD6A | S283 | ochoa | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}. |
| Q9NQW6 | ANLN | S344 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S349 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NZN8 | CNOT2 | S74 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9P0J7 | KCMF1 | S225 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P0K7 | RAI14 | S419 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P265 | DIP2B | S153 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UBI9 | HECA | Y277 | ochoa | Headcase protein homolog (hHDC) | May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. {ECO:0000303|PubMed:11696983}. |
| Q9UFC0 | LRWD1 | S264 | ochoa | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}. |
| Q9UGU0 | TCF20 | S884 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHB7 | AFF4 | S1075 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIW2 | PLXNA1 | S1619 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UKK3 | PARP4 | S1340 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UPV0 | CEP164 | S291 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ35 | SRRM2 | S1232 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y250 | LZTS1 | S146 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2I7 | PIKFYVE | S312 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2U8 | LEMD3 | S185 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y450 | HBS1L | S230 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y4B5 | MTCL1 | S209 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S1181 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| O75676 | RPS6KA4 | S700 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O94806 | PRKD3 | S49 | Sugiyama | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| P13804 | ETFA | S197 | Sugiyama | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P31749 | AKT1 | S137 | Sugiyama | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960, PubMed:29343641, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915, PubMed:12172553). Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 (PubMed:31548394, PubMed:33594058). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (By similarity). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF1 (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (PubMed:30504268). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:30504268, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}. |
| P51957 | NEK4 | S531 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q13162 | PRDX4 | S73 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
| P49327 | FASN | S1597 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q9Y316 | MEMO1 | S91 | Sugiyama | Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) | May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}. |
| O60814 | H2BC12 | S79 | EPSD | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P06899 | H2BC11 | S79 | EPSD | Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P23527 | H2BC17 | S79 | EPSD | Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P33778 | H2BC3 | S79 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P58876 | H2BC5 | S79 | EPSD | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | S79 | EPSD | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16778 | H2BC21 | S79 | EPSD | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q5QNW6 | H2BC18 | S79 | EPSD | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DN03 | H2BC20P | S79 | EPSD | Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6DRA6 | H2BC19P | S79 | EPSD | Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q93079 | H2BC9 | S79 | EPSD | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99877 | H2BC15 | S79 | EPSD | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S79 | EPSD | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P14598 | NCF1 | S288 | SIGNOR|EPSD|PSP | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 9.436896e-14 | 13.025 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.590950e-13 | 12.798 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.402034e-13 | 12.356 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.402034e-13 | 12.356 |
| R-HSA-5334118 | DNA methylation | 8.238965e-13 | 12.084 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.039946e-12 | 11.983 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.057243e-12 | 11.687 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.974199e-12 | 11.705 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.680856e-12 | 11.572 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.244627e-12 | 11.489 |
| R-HSA-774815 | Nucleosome assembly | 3.244627e-12 | 11.489 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.416245e-12 | 11.355 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.594103e-12 | 11.338 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.416245e-12 | 11.355 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.091794e-12 | 11.215 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 7.306156e-12 | 11.136 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 9.312551e-12 | 11.031 |
| R-HSA-110331 | Cleavage of the damaged purine | 9.312551e-12 | 11.031 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.070122e-11 | 10.971 |
| R-HSA-68875 | Mitotic Prophase | 1.053047e-11 | 10.978 |
| R-HSA-73927 | Depurination | 1.180267e-11 | 10.928 |
| R-HSA-1221632 | Meiotic synapsis | 1.615019e-11 | 10.792 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 1.615019e-11 | 10.792 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.865630e-11 | 10.729 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.865630e-11 | 10.729 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.727785e-11 | 10.763 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.852696e-11 | 10.732 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.330214e-11 | 10.633 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.327860e-11 | 10.633 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.573397e-11 | 10.447 |
| R-HSA-73928 | Depyrimidination | 3.573397e-11 | 10.447 |
| R-HSA-9710421 | Defective pyroptosis | 4.397815e-11 | 10.357 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.535350e-11 | 10.257 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.535350e-11 | 10.257 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.679035e-11 | 10.115 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 7.997569e-11 | 10.097 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.576051e-11 | 10.067 |
| R-HSA-3214847 | HATs acetylate histones | 9.430257e-11 | 10.025 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.435801e-10 | 9.843 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.937176e-10 | 9.713 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.008815e-10 | 9.697 |
| R-HSA-912446 | Meiotic recombination | 2.012663e-10 | 9.696 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.396721e-10 | 9.620 |
| R-HSA-69481 | G2/M Checkpoints | 2.523970e-10 | 9.598 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.989301e-10 | 9.524 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.367999e-10 | 9.473 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.440889e-10 | 9.463 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.430831e-10 | 9.192 |
| R-HSA-68886 | M Phase | 7.096504e-10 | 9.149 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.276341e-09 | 8.894 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.627812e-09 | 8.788 |
| R-HSA-1500620 | Meiosis | 1.834395e-09 | 8.737 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.832880e-09 | 8.737 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.832880e-09 | 8.737 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.200185e-09 | 8.658 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.572692e-09 | 8.447 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.068269e-09 | 8.391 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.916860e-09 | 8.407 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.078757e-09 | 8.389 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.383683e-09 | 8.269 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.639194e-09 | 8.249 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.592213e-09 | 8.120 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.846648e-09 | 8.053 |
| R-HSA-5693538 | Homology Directed Repair | 9.267795e-09 | 8.033 |
| R-HSA-73864 | RNA Polymerase I Transcription | 9.635934e-09 | 8.016 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.215725e-08 | 7.915 |
| R-HSA-1640170 | Cell Cycle | 1.307853e-08 | 7.883 |
| R-HSA-977225 | Amyloid fiber formation | 1.362617e-08 | 7.866 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.547358e-08 | 7.810 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.427559e-08 | 7.845 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.547358e-08 | 7.810 |
| R-HSA-446728 | Cell junction organization | 2.410929e-08 | 7.618 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.426025e-08 | 7.615 |
| R-HSA-211000 | Gene Silencing by RNA | 2.707095e-08 | 7.567 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.239379e-08 | 7.490 |
| R-HSA-421270 | Cell-cell junction organization | 3.516149e-08 | 7.454 |
| R-HSA-418990 | Adherens junctions interactions | 3.551522e-08 | 7.450 |
| R-HSA-73884 | Base Excision Repair | 3.968752e-08 | 7.401 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.593600e-08 | 7.338 |
| R-HSA-8852135 | Protein ubiquitination | 7.950291e-08 | 7.100 |
| R-HSA-157579 | Telomere Maintenance | 9.426772e-08 | 7.026 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.896818e-08 | 7.005 |
| R-HSA-73886 | Chromosome Maintenance | 1.044077e-07 | 6.981 |
| R-HSA-1500931 | Cell-Cell communication | 1.416078e-07 | 6.849 |
| R-HSA-2559583 | Cellular Senescence | 1.520541e-07 | 6.818 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.906441e-07 | 6.720 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.906441e-07 | 6.720 |
| R-HSA-1474165 | Reproduction | 2.387887e-07 | 6.622 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.898822e-07 | 6.409 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.904812e-07 | 6.309 |
| R-HSA-4839726 | Chromatin organization | 9.941779e-07 | 6.003 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.140576e-06 | 5.943 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.180582e-06 | 5.928 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.180582e-06 | 5.928 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.180582e-06 | 5.928 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.307578e-06 | 5.884 |
| R-HSA-69306 | DNA Replication | 1.231762e-06 | 5.909 |
| R-HSA-162582 | Signal Transduction | 1.285768e-06 | 5.891 |
| R-HSA-5688426 | Deubiquitination | 1.301353e-06 | 5.886 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 1.360124e-06 | 5.866 |
| R-HSA-9610379 | HCMV Late Events | 1.560423e-06 | 5.807 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.826086e-06 | 5.738 |
| R-HSA-9609690 | HCMV Early Events | 2.245673e-06 | 5.649 |
| R-HSA-8939211 | ESR-mediated signaling | 3.009119e-06 | 5.522 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.784876e-06 | 5.422 |
| R-HSA-2262752 | Cellular responses to stress | 6.006861e-06 | 5.221 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.467449e-05 | 4.833 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.618875e-05 | 4.791 |
| R-HSA-157118 | Signaling by NOTCH | 1.674679e-05 | 4.776 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.080201e-05 | 4.682 |
| R-HSA-9609646 | HCMV Infection | 2.468893e-05 | 4.607 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.829531e-05 | 4.548 |
| R-HSA-195721 | Signaling by WNT | 3.172594e-05 | 4.499 |
| R-HSA-194138 | Signaling by VEGF | 5.288772e-05 | 4.277 |
| R-HSA-73894 | DNA Repair | 5.657816e-05 | 4.247 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.807369e-04 | 3.743 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.204051e-04 | 3.657 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.624354e-04 | 3.581 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.308199e-04 | 3.480 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.038087e-03 | 2.984 |
| R-HSA-6804754 | Regulation of TP53 Expression | 1.085166e-03 | 2.965 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.157327e-03 | 2.937 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.414478e-03 | 2.849 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.591322e-03 | 2.798 |
| R-HSA-68882 | Mitotic Anaphase | 2.216108e-03 | 2.654 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.279161e-03 | 2.642 |
| R-HSA-74713 | IRS activation | 3.246609e-03 | 2.489 |
| R-HSA-68877 | Mitotic Prometaphase | 4.096110e-03 | 2.388 |
| R-HSA-75153 | Apoptotic execution phase | 4.133681e-03 | 2.384 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 4.207650e-03 | 2.376 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 4.207650e-03 | 2.376 |
| R-HSA-168256 | Immune System | 4.219810e-03 | 2.375 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.236092e-03 | 2.373 |
| R-HSA-437239 | Recycling pathway of L1 | 4.408157e-03 | 2.356 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.567774e-03 | 2.254 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.567774e-03 | 2.254 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 7.388624e-03 | 2.131 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.770160e-03 | 2.110 |
| R-HSA-196025 | Formation of annular gap junctions | 7.772155e-03 | 2.109 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 7.772155e-03 | 2.109 |
| R-HSA-190873 | Gap junction degradation | 9.178193e-03 | 2.037 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 1.179144e-02 | 1.928 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 1.179144e-02 | 1.928 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.068866e-02 | 1.971 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.161893e-02 | 1.935 |
| R-HSA-74749 | Signal attenuation | 1.068866e-02 | 1.971 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.090051e-02 | 1.963 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.006265e-02 | 1.997 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.080774e-02 | 1.966 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.131567e-02 | 1.946 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.230092e-02 | 1.910 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.401240e-02 | 1.853 |
| R-HSA-8853659 | RET signaling | 1.500399e-02 | 1.824 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.528313e-02 | 1.816 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.582055e-02 | 1.801 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.593858e-02 | 1.798 |
| R-HSA-1280218 | Adaptive Immune System | 1.599611e-02 | 1.796 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.772287e-02 | 1.751 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.772287e-02 | 1.751 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.772287e-02 | 1.751 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.790410e-02 | 1.747 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.790410e-02 | 1.747 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.999857e-02 | 1.699 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.065936e-02 | 1.685 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.109429e-02 | 1.676 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.109429e-02 | 1.676 |
| R-HSA-109581 | Apoptosis | 2.124335e-02 | 1.673 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.180033e-02 | 1.662 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.180033e-02 | 1.662 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.180033e-02 | 1.662 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.319543e-02 | 1.635 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 2.344456e-02 | 1.630 |
| R-HSA-169893 | Prolonged ERK activation events | 2.397068e-02 | 1.620 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.622569e-02 | 1.581 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.705824e-02 | 1.568 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.705824e-02 | 1.568 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.705824e-02 | 1.568 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.556295e-02 | 1.592 |
| R-HSA-3928664 | Ephrin signaling | 3.098059e-02 | 1.509 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.705824e-02 | 1.568 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.966983e-02 | 1.528 |
| R-HSA-157858 | Gap junction trafficking and regulation | 3.102383e-02 | 1.508 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.872190e-02 | 1.542 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.711101e-02 | 1.567 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.457564e-02 | 1.609 |
| R-HSA-9824446 | Viral Infection Pathways | 3.232125e-02 | 1.491 |
| R-HSA-9834899 | Specification of the neural plate border | 3.347606e-02 | 1.475 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.347606e-02 | 1.475 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 3.496098e-02 | 1.456 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.604732e-02 | 1.443 |
| R-HSA-445355 | Smooth Muscle Contraction | 3.675892e-02 | 1.435 |
| R-HSA-198753 | ERK/MAPK targets | 3.869226e-02 | 1.412 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.299846e-02 | 1.367 |
| R-HSA-70171 | Glycolysis | 4.417488e-02 | 1.355 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.419490e-02 | 1.355 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.419490e-02 | 1.355 |
| R-HSA-449147 | Signaling by Interleukins | 4.536342e-02 | 1.343 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 4.634229e-02 | 1.334 |
| R-HSA-198765 | Signalling to ERK5 | 4.634229e-02 | 1.334 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 5.759007e-02 | 1.240 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 6.870587e-02 | 1.163 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.704858e-02 | 1.327 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.599556e-02 | 1.252 |
| R-HSA-9006335 | Signaling by Erythropoietin | 6.548216e-02 | 1.184 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.328045e-02 | 1.273 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.328045e-02 | 1.273 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.882475e-02 | 1.230 |
| R-HSA-191650 | Regulation of gap junction activity | 6.870587e-02 | 1.163 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 6.870587e-02 | 1.163 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 6.870587e-02 | 1.163 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 5.910024e-02 | 1.228 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.870587e-02 | 1.163 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 6.870587e-02 | 1.163 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 6.870587e-02 | 1.163 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.910024e-02 | 1.228 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 6.548216e-02 | 1.184 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 6.875585e-02 | 1.163 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.800306e-02 | 1.319 |
| R-HSA-373755 | Semaphorin interactions | 5.328045e-02 | 1.273 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 6.870587e-02 | 1.163 |
| R-HSA-114452 | Activation of BH3-only proteins | 6.875585e-02 | 1.163 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 4.704858e-02 | 1.327 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.701370e-02 | 1.174 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.996786e-02 | 1.301 |
| R-HSA-166520 | Signaling by NTRKs | 4.897533e-02 | 1.310 |
| R-HSA-9707616 | Heme signaling | 5.149136e-02 | 1.288 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.328045e-02 | 1.273 |
| R-HSA-8848021 | Signaling by PTK6 | 5.328045e-02 | 1.273 |
| R-HSA-5357801 | Programmed Cell Death | 5.297241e-02 | 1.276 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.996786e-02 | 1.301 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.996786e-02 | 1.301 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.875585e-02 | 1.163 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.704858e-02 | 1.327 |
| R-HSA-373760 | L1CAM interactions | 7.024351e-02 | 1.153 |
| R-HSA-70326 | Glucose metabolism | 7.179454e-02 | 1.144 |
| R-HSA-186763 | Downstream signal transduction | 7.208241e-02 | 1.142 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 7.276213e-02 | 1.138 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 7.276213e-02 | 1.138 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.336303e-02 | 1.135 |
| R-HSA-422475 | Axon guidance | 7.577588e-02 | 1.120 |
| R-HSA-380287 | Centrosome maturation | 7.699191e-02 | 1.114 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.699191e-02 | 1.114 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 7.888738e-02 | 1.103 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 7.888738e-02 | 1.103 |
| R-HSA-354192 | Integrin signaling | 7.888738e-02 | 1.103 |
| R-HSA-397795 | G-protein beta:gamma signalling | 7.888738e-02 | 1.103 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.969124e-02 | 1.099 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 7.969124e-02 | 1.099 |
| R-HSA-212436 | Generic Transcription Pathway | 8.131866e-02 | 1.090 |
| R-HSA-416482 | G alpha (12/13) signalling events | 8.353436e-02 | 1.078 |
| R-HSA-187687 | Signalling to ERKs | 8.945013e-02 | 1.048 |
| R-HSA-1266738 | Developmental Biology | 9.005192e-02 | 1.046 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 9.054770e-02 | 1.043 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 9.054770e-02 | 1.043 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 9.305952e-02 | 1.031 |
| R-HSA-69205 | G1/S-Specific Transcription | 9.305952e-02 | 1.031 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.530208e-02 | 1.021 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.012768e-01 | 0.994 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.012768e-01 | 0.994 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 1.012768e-01 | 0.994 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.012768e-01 | 0.994 |
| R-HSA-112412 | SOS-mediated signalling | 1.118799e-01 | 0.951 |
| R-HSA-8875656 | MET receptor recycling | 1.223586e-01 | 0.912 |
| R-HSA-170984 | ARMS-mediated activation | 1.327143e-01 | 0.877 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.327143e-01 | 0.877 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.429484e-01 | 0.845 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.429484e-01 | 0.845 |
| R-HSA-202670 | ERKs are inactivated | 1.630576e-01 | 0.788 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.729355e-01 | 0.762 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.729355e-01 | 0.762 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.923448e-01 | 0.716 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.923448e-01 | 0.716 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 9.671062e-02 | 1.015 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.596824e-01 | 0.797 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.094269e-01 | 0.961 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.144338e-01 | 0.941 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.923448e-01 | 0.716 |
| R-HSA-198203 | PI3K/AKT activation | 1.429484e-01 | 0.845 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.272500e-01 | 0.895 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.638391e-01 | 0.786 |
| R-HSA-162592 | Integration of provirus | 1.630576e-01 | 0.788 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.625522e-01 | 0.789 |
| R-HSA-9909396 | Circadian clock | 1.007599e-01 | 0.997 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 1.630576e-01 | 0.788 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.806483e-01 | 0.743 |
| R-HSA-199920 | CREB phosphorylation | 1.012768e-01 | 0.994 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.327143e-01 | 0.877 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.826975e-01 | 0.738 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.078996e-01 | 0.967 |
| R-HSA-8875878 | MET promotes cell motility | 1.004019e-01 | 0.998 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.118799e-01 | 0.951 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.223586e-01 | 0.912 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.260059e-01 | 0.900 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 1.012768e-01 | 0.994 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.327143e-01 | 0.877 |
| R-HSA-164843 | 2-LTR circle formation | 1.429484e-01 | 0.845 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.429484e-01 | 0.845 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.429484e-01 | 0.845 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.630576e-01 | 0.788 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.730105e-02 | 1.012 |
| R-HSA-162587 | HIV Life Cycle | 1.558393e-01 | 0.807 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.733067e-01 | 0.761 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.153380e-01 | 0.938 |
| R-HSA-162906 | HIV Infection | 1.717016e-01 | 0.765 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.312136e-01 | 0.882 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.118799e-01 | 0.951 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.223586e-01 | 0.912 |
| R-HSA-428540 | Activation of RAC1 | 1.630576e-01 | 0.788 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.826975e-01 | 0.738 |
| R-HSA-164944 | Nef and signal transduction | 1.012768e-01 | 0.994 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.530624e-01 | 0.815 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.923448e-01 | 0.716 |
| R-HSA-190828 | Gap junction trafficking | 1.272500e-01 | 0.895 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.891483e-01 | 0.723 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.826975e-01 | 0.738 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.923448e-01 | 0.716 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.716411e-01 | 0.765 |
| R-HSA-170968 | Frs2-mediated activation | 1.826975e-01 | 0.738 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.117030e-01 | 0.952 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.638391e-01 | 0.786 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.429484e-01 | 0.845 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 1.530624e-01 | 0.815 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.764207e-01 | 0.753 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.406945e-01 | 0.852 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.406945e-01 | 0.852 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.406945e-01 | 0.852 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.745464e-01 | 0.758 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.774656e-01 | 0.751 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.774656e-01 | 0.751 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.630116e-01 | 0.788 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.764207e-01 | 0.753 |
| R-HSA-9675108 | Nervous system development | 1.055610e-01 | 0.976 |
| R-HSA-177929 | Signaling by EGFR | 1.764207e-01 | 0.753 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.863033e-01 | 0.730 |
| R-HSA-9607240 | FLT3 Signaling | 1.117030e-01 | 0.952 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.327143e-01 | 0.877 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.826975e-01 | 0.738 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.392241e-01 | 0.856 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.482717e-01 | 0.829 |
| R-HSA-2586552 | Signaling by Leptin | 1.429484e-01 | 0.845 |
| R-HSA-165159 | MTOR signalling | 1.194126e-01 | 0.923 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.223586e-01 | 0.912 |
| R-HSA-877300 | Interferon gamma signaling | 1.603028e-01 | 0.795 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.764207e-01 | 0.753 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.312136e-01 | 0.882 |
| R-HSA-8983711 | OAS antiviral response | 1.729355e-01 | 0.762 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.687499e-01 | 0.773 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.687499e-01 | 0.773 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.492344e-01 | 0.826 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.194126e-01 | 0.923 |
| R-HSA-913531 | Interferon Signaling | 1.098702e-01 | 0.959 |
| R-HSA-74160 | Gene expression (Transcription) | 1.936530e-01 | 0.713 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.952540e-01 | 0.709 |
| R-HSA-450294 | MAP kinase activation | 1.977019e-01 | 0.704 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.018788e-01 | 0.695 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.018788e-01 | 0.695 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.018788e-01 | 0.695 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.018788e-01 | 0.695 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.018788e-01 | 0.695 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.018788e-01 | 0.695 |
| R-HSA-416700 | Other semaphorin interactions | 2.018788e-01 | 0.695 |
| R-HSA-186797 | Signaling by PDGF | 2.019965e-01 | 0.695 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.063019e-01 | 0.685 |
| R-HSA-6798695 | Neutrophil degranulation | 2.093131e-01 | 0.679 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.103990e-01 | 0.677 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.103990e-01 | 0.677 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.106172e-01 | 0.677 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.113008e-01 | 0.675 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.113008e-01 | 0.675 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 2.113008e-01 | 0.675 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.113008e-01 | 0.675 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.113008e-01 | 0.675 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.113008e-01 | 0.675 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.113008e-01 | 0.675 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.149415e-01 | 0.668 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.196082e-01 | 0.658 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.196082e-01 | 0.658 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.206122e-01 | 0.656 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.206122e-01 | 0.656 |
| R-HSA-5663205 | Infectious disease | 2.225920e-01 | 0.652 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.226965e-01 | 0.652 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.257935e-01 | 0.646 |
| R-HSA-69275 | G2/M Transition | 2.271209e-01 | 0.644 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.279610e-01 | 0.642 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 2.298143e-01 | 0.639 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.298143e-01 | 0.639 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.298143e-01 | 0.639 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.298143e-01 | 0.639 |
| R-HSA-2028269 | Signaling by Hippo | 2.298143e-01 | 0.639 |
| R-HSA-69206 | G1/S Transition | 2.320124e-01 | 0.634 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.321515e-01 | 0.634 |
| R-HSA-448424 | Interleukin-17 signaling | 2.366716e-01 | 0.626 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.389082e-01 | 0.622 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.389082e-01 | 0.622 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 2.422941e-01 | 0.616 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.454001e-01 | 0.610 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.454001e-01 | 0.610 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.454001e-01 | 0.610 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.474035e-01 | 0.607 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.478953e-01 | 0.606 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.478953e-01 | 0.606 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.478953e-01 | 0.606 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.478953e-01 | 0.606 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.478953e-01 | 0.606 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.478953e-01 | 0.606 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.497694e-01 | 0.602 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.541410e-01 | 0.595 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.541410e-01 | 0.595 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.567769e-01 | 0.590 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.567769e-01 | 0.590 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.567769e-01 | 0.590 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.585144e-01 | 0.588 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.609477e-01 | 0.583 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.628889e-01 | 0.580 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.655541e-01 | 0.576 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.655541e-01 | 0.576 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.672638e-01 | 0.573 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.716386e-01 | 0.566 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.742282e-01 | 0.562 |
| R-HSA-72172 | mRNA Splicing | 2.758958e-01 | 0.559 |
| R-HSA-9659379 | Sensory processing of sound | 2.760127e-01 | 0.559 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 2.760127e-01 | 0.559 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.803854e-01 | 0.552 |
| R-HSA-6806834 | Signaling by MET | 2.803854e-01 | 0.552 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.825421e-01 | 0.549 |
| R-HSA-6807070 | PTEN Regulation | 2.826942e-01 | 0.549 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.828004e-01 | 0.549 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.828004e-01 | 0.549 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.828004e-01 | 0.549 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.859015e-01 | 0.544 |
| R-HSA-9664407 | Parasite infection | 2.859015e-01 | 0.544 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.859015e-01 | 0.544 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.891119e-01 | 0.539 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.893706e-01 | 0.539 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.912719e-01 | 0.536 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.912719e-01 | 0.536 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.912719e-01 | 0.536 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.912719e-01 | 0.536 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.955407e-01 | 0.529 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.996438e-01 | 0.523 |
| R-HSA-429947 | Deadenylation of mRNA | 2.996438e-01 | 0.523 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.022092e-01 | 0.520 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.054172e-01 | 0.515 |
| R-HSA-420029 | Tight junction interactions | 3.079173e-01 | 0.512 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.079173e-01 | 0.512 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.079173e-01 | 0.512 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.079173e-01 | 0.512 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.079173e-01 | 0.512 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.079173e-01 | 0.512 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.084236e-01 | 0.511 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.109103e-01 | 0.507 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.148738e-01 | 0.502 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.152527e-01 | 0.501 |
| R-HSA-70268 | Pyruvate metabolism | 3.152527e-01 | 0.501 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.152527e-01 | 0.501 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.160936e-01 | 0.500 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.160936e-01 | 0.500 |
| R-HSA-70635 | Urea cycle | 3.160936e-01 | 0.500 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.215956e-01 | 0.493 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.241738e-01 | 0.489 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.241738e-01 | 0.489 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.241738e-01 | 0.489 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.241738e-01 | 0.489 |
| R-HSA-201451 | Signaling by BMP | 3.241738e-01 | 0.489 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.241738e-01 | 0.489 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.241738e-01 | 0.489 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.277821e-01 | 0.484 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.321591e-01 | 0.479 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.321591e-01 | 0.479 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.321591e-01 | 0.479 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.321591e-01 | 0.479 |
| R-HSA-5620971 | Pyroptosis | 3.321591e-01 | 0.479 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.321591e-01 | 0.479 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.400504e-01 | 0.468 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.400504e-01 | 0.468 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.400504e-01 | 0.468 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.400504e-01 | 0.468 |
| R-HSA-74752 | Signaling by Insulin receptor | 3.411650e-01 | 0.467 |
| R-HSA-391251 | Protein folding | 3.411650e-01 | 0.467 |
| R-HSA-597592 | Post-translational protein modification | 3.449069e-01 | 0.462 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.471041e-01 | 0.460 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.478490e-01 | 0.459 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.478490e-01 | 0.459 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.478490e-01 | 0.459 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.478490e-01 | 0.459 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.478490e-01 | 0.459 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.497379e-01 | 0.456 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.535793e-01 | 0.452 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.555560e-01 | 0.449 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.555560e-01 | 0.449 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.555560e-01 | 0.449 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.555560e-01 | 0.449 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.555560e-01 | 0.449 |
| R-HSA-182971 | EGFR downregulation | 3.555560e-01 | 0.449 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.625258e-01 | 0.441 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.625258e-01 | 0.441 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.631723e-01 | 0.440 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.631723e-01 | 0.440 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.667679e-01 | 0.436 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.667679e-01 | 0.436 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.706991e-01 | 0.431 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.706991e-01 | 0.431 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.706991e-01 | 0.431 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.752194e-01 | 0.426 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.781373e-01 | 0.422 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.781373e-01 | 0.422 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.781373e-01 | 0.422 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.781373e-01 | 0.422 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.781373e-01 | 0.422 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.836248e-01 | 0.416 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.854881e-01 | 0.414 |
| R-HSA-203615 | eNOS activation | 3.854881e-01 | 0.414 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.854881e-01 | 0.414 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.854881e-01 | 0.414 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.854881e-01 | 0.414 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.854881e-01 | 0.414 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.878096e-01 | 0.411 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.927525e-01 | 0.406 |
| R-HSA-169911 | Regulation of Apoptosis | 3.927525e-01 | 0.406 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.927525e-01 | 0.406 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.927525e-01 | 0.406 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.927525e-01 | 0.406 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.927525e-01 | 0.406 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.961415e-01 | 0.402 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.999314e-01 | 0.398 |
| R-HSA-3371511 | HSF1 activation | 3.999314e-01 | 0.398 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.999314e-01 | 0.398 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.015569e-01 | 0.396 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.047251e-01 | 0.393 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.070260e-01 | 0.390 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.070260e-01 | 0.390 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.140370e-01 | 0.383 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.140370e-01 | 0.383 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.140370e-01 | 0.383 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.167395e-01 | 0.380 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.209656e-01 | 0.376 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.209656e-01 | 0.376 |
| R-HSA-69541 | Stabilization of p53 | 4.209656e-01 | 0.376 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.209656e-01 | 0.376 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.278127e-01 | 0.369 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.278127e-01 | 0.369 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.278127e-01 | 0.369 |
| R-HSA-9646399 | Aggrephagy | 4.278127e-01 | 0.369 |
| R-HSA-167169 | HIV Transcription Elongation | 4.278127e-01 | 0.369 |
| R-HSA-3371568 | Attenuation phase | 4.278127e-01 | 0.369 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.278127e-01 | 0.369 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.278127e-01 | 0.369 |
| R-HSA-202433 | Generation of second messenger molecules | 4.278127e-01 | 0.369 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.345793e-01 | 0.362 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.345793e-01 | 0.362 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.345793e-01 | 0.362 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.409845e-01 | 0.356 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.412662e-01 | 0.355 |
| R-HSA-1643685 | Disease | 4.431845e-01 | 0.353 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.489439e-01 | 0.348 |
| R-HSA-5617833 | Cilium Assembly | 4.515886e-01 | 0.345 |
| R-HSA-8854214 | TBC/RABGAPs | 4.544050e-01 | 0.343 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.544050e-01 | 0.343 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.544050e-01 | 0.343 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.546623e-01 | 0.342 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.607632e-01 | 0.337 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.615666e-01 | 0.336 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.672364e-01 | 0.330 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.672364e-01 | 0.330 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.685607e-01 | 0.329 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.735390e-01 | 0.325 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.735390e-01 | 0.325 |
| R-HSA-9675135 | Diseases of DNA repair | 4.735390e-01 | 0.325 |
| R-HSA-3371556 | Cellular response to heat stress | 4.762913e-01 | 0.322 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.797675e-01 | 0.319 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.920055e-01 | 0.308 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.920055e-01 | 0.308 |
| R-HSA-109704 | PI3K Cascade | 4.980166e-01 | 0.303 |
| R-HSA-114608 | Platelet degranulation | 5.028047e-01 | 0.299 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.039570e-01 | 0.298 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.098274e-01 | 0.293 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.156288e-01 | 0.288 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.177458e-01 | 0.286 |
| R-HSA-397014 | Muscle contraction | 5.202930e-01 | 0.284 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.248351e-01 | 0.280 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.284429e-01 | 0.277 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.326261e-01 | 0.274 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.326261e-01 | 0.274 |
| R-HSA-112399 | IRS-mediated signalling | 5.381590e-01 | 0.269 |
| R-HSA-168249 | Innate Immune System | 5.389238e-01 | 0.268 |
| R-HSA-199991 | Membrane Trafficking | 5.407426e-01 | 0.267 |
| R-HSA-163685 | Integration of energy metabolism | 5.426885e-01 | 0.265 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.436267e-01 | 0.265 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.490300e-01 | 0.260 |
| R-HSA-191859 | snRNP Assembly | 5.490300e-01 | 0.260 |
| R-HSA-186712 | Regulation of beta-cell development | 5.490300e-01 | 0.260 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.543697e-01 | 0.256 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.543697e-01 | 0.256 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.596465e-01 | 0.252 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.596465e-01 | 0.252 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.648611e-01 | 0.248 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.648611e-01 | 0.248 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.648611e-01 | 0.248 |
| R-HSA-8953854 | Metabolism of RNA | 5.649704e-01 | 0.248 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.652604e-01 | 0.248 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.700143e-01 | 0.244 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.751067e-01 | 0.240 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.801392e-01 | 0.236 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.836175e-01 | 0.234 |
| R-HSA-69242 | S Phase | 5.869045e-01 | 0.231 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.900270e-01 | 0.229 |
| R-HSA-196807 | Nicotinate metabolism | 5.900270e-01 | 0.229 |
| R-HSA-9758941 | Gastrulation | 5.901724e-01 | 0.229 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.934212e-01 | 0.227 |
| R-HSA-167172 | Transcription of the HIV genome | 5.948836e-01 | 0.226 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.948836e-01 | 0.226 |
| R-HSA-5218859 | Regulated Necrosis | 5.948836e-01 | 0.226 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 6.044259e-01 | 0.219 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.044259e-01 | 0.219 |
| R-HSA-73887 | Death Receptor Signaling | 6.062249e-01 | 0.217 |
| R-HSA-8978934 | Metabolism of cofactors | 6.091129e-01 | 0.215 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.137446e-01 | 0.212 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.137446e-01 | 0.212 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.183217e-01 | 0.209 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.183217e-01 | 0.209 |
| R-HSA-9013694 | Signaling by NOTCH4 | 6.228448e-01 | 0.206 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.228448e-01 | 0.206 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.273147e-01 | 0.203 |
| R-HSA-5689603 | UCH proteinases | 6.317318e-01 | 0.199 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.360969e-01 | 0.196 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.392909e-01 | 0.194 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.404104e-01 | 0.194 |
| R-HSA-4086400 | PCP/CE pathway | 6.404104e-01 | 0.194 |
| R-HSA-9833482 | PKR-mediated signaling | 6.488856e-01 | 0.188 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.571620e-01 | 0.182 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.600697e-01 | 0.180 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.652443e-01 | 0.177 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.692141e-01 | 0.174 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.731371e-01 | 0.172 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.808447e-01 | 0.167 |
| R-HSA-9663891 | Selective autophagy | 6.846305e-01 | 0.165 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.945994e-01 | 0.158 |
| R-HSA-9658195 | Leishmania infection | 6.945994e-01 | 0.158 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.957217e-01 | 0.158 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.028994e-01 | 0.153 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 7.299647e-01 | 0.137 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.299647e-01 | 0.137 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.342623e-01 | 0.134 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.363386e-01 | 0.133 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.388363e-01 | 0.131 |
| R-HSA-1483255 | PI Metabolism | 7.394692e-01 | 0.131 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.394692e-01 | 0.131 |
| R-HSA-9833110 | RSV-host interactions | 7.486408e-01 | 0.126 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.516261e-01 | 0.124 |
| R-HSA-69239 | Synthesis of DNA | 7.574912e-01 | 0.121 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.603719e-01 | 0.119 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.603719e-01 | 0.119 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.648953e-01 | 0.116 |
| R-HSA-202403 | TCR signaling | 7.660316e-01 | 0.116 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 7.660316e-01 | 0.116 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.697821e-01 | 0.114 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.714225e-01 | 0.113 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.715582e-01 | 0.113 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.715582e-01 | 0.113 |
| R-HSA-8957322 | Metabolism of steroids | 7.765724e-01 | 0.110 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.873710e-01 | 0.104 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.873710e-01 | 0.104 |
| R-HSA-1474244 | Extracellular matrix organization | 7.880618e-01 | 0.103 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.979506e-01 | 0.098 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.036270e-01 | 0.095 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.067734e-01 | 0.093 |
| R-HSA-9679506 | SARS-CoV Infections | 8.161549e-01 | 0.088 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.184818e-01 | 0.087 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.358278e-01 | 0.078 |
| R-HSA-388396 | GPCR downstream signalling | 8.363659e-01 | 0.078 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.385293e-01 | 0.076 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.404514e-01 | 0.075 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.423508e-01 | 0.075 |
| R-HSA-109582 | Hemostasis | 8.454829e-01 | 0.073 |
| R-HSA-1632852 | Macroautophagy | 8.479149e-01 | 0.072 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.506026e-01 | 0.070 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.515154e-01 | 0.070 |
| R-HSA-416476 | G alpha (q) signalling events | 8.519848e-01 | 0.070 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.573985e-01 | 0.067 |
| R-HSA-392499 | Metabolism of proteins | 8.601181e-01 | 0.065 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.650890e-01 | 0.063 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.666964e-01 | 0.062 |
| R-HSA-9609507 | Protein localization | 8.698544e-01 | 0.061 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.729380e-01 | 0.059 |
| R-HSA-1989781 | PPARA activates gene expression | 8.729380e-01 | 0.059 |
| R-HSA-9612973 | Autophagy | 8.744524e-01 | 0.058 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.759489e-01 | 0.058 |
| R-HSA-5619102 | SLC transporter disorders | 8.899713e-01 | 0.051 |
| R-HSA-72306 | tRNA processing | 8.951281e-01 | 0.048 |
| R-HSA-372790 | Signaling by GPCR | 9.003583e-01 | 0.046 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.012373e-01 | 0.045 |
| R-HSA-611105 | Respiratory electron transport | 9.047315e-01 | 0.043 |
| R-HSA-168255 | Influenza Infection | 9.058687e-01 | 0.043 |
| R-HSA-983712 | Ion channel transport | 9.165235e-01 | 0.038 |
| R-HSA-428157 | Sphingolipid metabolism | 9.277368e-01 | 0.033 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.294542e-01 | 0.032 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.294542e-01 | 0.032 |
| R-HSA-6805567 | Keratinization | 9.327681e-01 | 0.030 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.374507e-01 | 0.028 |
| R-HSA-8951664 | Neddylation | 9.438732e-01 | 0.025 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.589709e-01 | 0.018 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.689243e-01 | 0.014 |
| R-HSA-72766 | Translation | 9.710765e-01 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 9.770236e-01 | 0.010 |
| R-HSA-112316 | Neuronal System | 9.806815e-01 | 0.008 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.836304e-01 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.931733e-01 | 0.003 |
| R-HSA-418594 | G alpha (i) signalling events | 9.941730e-01 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 9.941730e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.993738e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.995622e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997839e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999953e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999969e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.802 | 0.130 | 2 | 0.775 |
MOS |
0.788 | 0.103 | 1 | 0.792 |
KIS |
0.787 | 0.106 | 1 | 0.582 |
CLK3 |
0.786 | 0.091 | 1 | 0.710 |
CDC7 |
0.785 | 0.004 | 1 | 0.756 |
GRK1 |
0.784 | 0.125 | -2 | 0.742 |
IKKB |
0.783 | 0.081 | -2 | 0.664 |
TBK1 |
0.782 | 0.084 | 1 | 0.728 |
CHAK2 |
0.781 | 0.102 | -1 | 0.777 |
PRPK |
0.781 | -0.016 | -1 | 0.803 |
MLK1 |
0.781 | 0.078 | 2 | 0.748 |
MTOR |
0.778 | 0.011 | 1 | 0.713 |
IKKE |
0.778 | 0.058 | 1 | 0.734 |
TGFBR2 |
0.777 | 0.057 | -2 | 0.837 |
DSTYK |
0.777 | 0.003 | 2 | 0.768 |
RIPK3 |
0.777 | 0.034 | 3 | 0.708 |
SKMLCK |
0.776 | 0.057 | -2 | 0.801 |
PDHK4 |
0.776 | -0.049 | 1 | 0.803 |
BMPR2 |
0.776 | 0.022 | -2 | 0.847 |
ATR |
0.776 | 0.022 | 1 | 0.754 |
RAF1 |
0.776 | -0.007 | 1 | 0.806 |
NDR2 |
0.776 | -0.037 | -3 | 0.821 |
NEK6 |
0.774 | 0.007 | -2 | 0.828 |
GCN2 |
0.774 | -0.108 | 2 | 0.722 |
GRK5 |
0.774 | 0.009 | -3 | 0.888 |
PIM3 |
0.774 | -0.031 | -3 | 0.816 |
ULK2 |
0.774 | -0.059 | 2 | 0.734 |
NLK |
0.773 | 0.002 | 1 | 0.737 |
BMPR1B |
0.773 | 0.135 | 1 | 0.701 |
NUAK2 |
0.772 | -0.016 | -3 | 0.801 |
NEK7 |
0.771 | -0.041 | -3 | 0.849 |
GRK7 |
0.771 | 0.111 | 1 | 0.667 |
IRE1 |
0.770 | 0.053 | 1 | 0.779 |
PDHK1 |
0.770 | -0.057 | 1 | 0.811 |
IKKA |
0.770 | 0.014 | -2 | 0.670 |
CDKL1 |
0.770 | -0.012 | -3 | 0.770 |
SRPK1 |
0.769 | 0.027 | -3 | 0.717 |
WNK1 |
0.769 | -0.022 | -2 | 0.800 |
CAMK2G |
0.769 | -0.060 | 2 | 0.685 |
MST4 |
0.769 | -0.000 | 2 | 0.748 |
MARK4 |
0.769 | -0.004 | 4 | 0.833 |
CAMK1B |
0.769 | -0.061 | -3 | 0.826 |
GRK6 |
0.768 | 0.033 | 1 | 0.759 |
LATS2 |
0.768 | -0.030 | -5 | 0.320 |
AMPKA1 |
0.768 | -0.002 | -3 | 0.819 |
PKN3 |
0.768 | -0.039 | -3 | 0.801 |
TSSK1 |
0.768 | 0.017 | -3 | 0.833 |
PKN2 |
0.768 | -0.014 | -3 | 0.811 |
TSSK2 |
0.768 | -0.011 | -5 | 0.417 |
LATS1 |
0.768 | 0.068 | -3 | 0.831 |
FAM20C |
0.768 | 0.025 | 2 | 0.511 |
MLK3 |
0.768 | 0.043 | 2 | 0.682 |
HIPK4 |
0.767 | 0.017 | 1 | 0.756 |
ERK5 |
0.767 | -0.017 | 1 | 0.684 |
PLK1 |
0.767 | 0.088 | -2 | 0.794 |
BCKDK |
0.766 | -0.045 | -1 | 0.753 |
PKCD |
0.766 | 0.002 | 2 | 0.719 |
HUNK |
0.766 | -0.077 | 2 | 0.733 |
NIK |
0.766 | -0.042 | -3 | 0.860 |
GRK4 |
0.765 | -0.009 | -2 | 0.790 |
MLK4 |
0.765 | 0.052 | 2 | 0.677 |
RSK2 |
0.765 | -0.014 | -3 | 0.722 |
CDKL5 |
0.765 | -0.000 | -3 | 0.756 |
ALK4 |
0.765 | 0.118 | -2 | 0.869 |
IRE2 |
0.765 | 0.036 | 2 | 0.742 |
NDR1 |
0.764 | -0.076 | -3 | 0.805 |
ULK1 |
0.764 | -0.080 | -3 | 0.813 |
ANKRD3 |
0.764 | 0.020 | 1 | 0.799 |
CAMLCK |
0.764 | -0.044 | -2 | 0.781 |
TTBK2 |
0.764 | -0.045 | 2 | 0.651 |
NEK9 |
0.763 | -0.048 | 2 | 0.764 |
TLK2 |
0.763 | 0.095 | 1 | 0.773 |
ACVR2A |
0.762 | 0.094 | -2 | 0.820 |
PRKD1 |
0.762 | -0.061 | -3 | 0.780 |
AMPKA2 |
0.762 | -0.012 | -3 | 0.779 |
MLK2 |
0.762 | -0.017 | 2 | 0.745 |
TGFBR1 |
0.762 | 0.085 | -2 | 0.862 |
P90RSK |
0.761 | -0.033 | -3 | 0.732 |
DLK |
0.761 | -0.014 | 1 | 0.765 |
RIPK1 |
0.761 | -0.060 | 1 | 0.788 |
ACVR2B |
0.761 | 0.088 | -2 | 0.828 |
DAPK2 |
0.761 | -0.035 | -3 | 0.838 |
WNK3 |
0.761 | -0.095 | 1 | 0.785 |
PKACG |
0.760 | -0.016 | -2 | 0.689 |
PKCB |
0.760 | 0.013 | 2 | 0.686 |
CDK1 |
0.760 | 0.047 | 1 | 0.513 |
AURC |
0.760 | 0.009 | -2 | 0.608 |
PKR |
0.760 | 0.036 | 1 | 0.817 |
NIM1 |
0.759 | -0.035 | 3 | 0.748 |
ICK |
0.759 | -0.009 | -3 | 0.805 |
MASTL |
0.759 | -0.116 | -2 | 0.746 |
PKCA |
0.759 | 0.006 | 2 | 0.673 |
CAMK2D |
0.758 | -0.060 | -3 | 0.803 |
PKCG |
0.758 | -0.008 | 2 | 0.677 |
CDK8 |
0.758 | -0.011 | 1 | 0.551 |
PIM1 |
0.758 | -0.038 | -3 | 0.747 |
CK1E |
0.758 | 0.063 | -3 | 0.614 |
CDK5 |
0.758 | 0.029 | 1 | 0.568 |
DYRK2 |
0.758 | 0.023 | 1 | 0.636 |
ALK2 |
0.758 | 0.087 | -2 | 0.853 |
SRPK2 |
0.758 | 0.005 | -3 | 0.629 |
ATM |
0.757 | -0.037 | 1 | 0.695 |
YSK4 |
0.757 | 0.022 | 1 | 0.739 |
RSK3 |
0.756 | -0.059 | -3 | 0.719 |
VRK2 |
0.756 | 0.060 | 1 | 0.808 |
BMPR1A |
0.756 | 0.116 | 1 | 0.682 |
SRPK3 |
0.756 | 0.010 | -3 | 0.694 |
MEKK3 |
0.756 | 0.126 | 1 | 0.752 |
MAPKAPK3 |
0.756 | -0.076 | -3 | 0.724 |
CDK19 |
0.756 | -0.002 | 1 | 0.512 |
PRKD2 |
0.755 | -0.057 | -3 | 0.712 |
PKCH |
0.755 | -0.016 | 2 | 0.683 |
CK1G1 |
0.755 | 0.066 | -3 | 0.621 |
PKCZ |
0.755 | 0.004 | 2 | 0.720 |
CHAK1 |
0.754 | -0.021 | 2 | 0.698 |
NUAK1 |
0.754 | -0.054 | -3 | 0.737 |
JNK3 |
0.754 | 0.028 | 1 | 0.540 |
MNK2 |
0.754 | -0.022 | -2 | 0.723 |
QSK |
0.754 | -0.019 | 4 | 0.809 |
CAMK2B |
0.754 | -0.022 | 2 | 0.631 |
PKG2 |
0.752 | 0.003 | -2 | 0.627 |
MEKK2 |
0.752 | 0.087 | 2 | 0.743 |
RSK4 |
0.752 | -0.019 | -3 | 0.699 |
QIK |
0.752 | -0.062 | -3 | 0.800 |
P70S6KB |
0.752 | -0.069 | -3 | 0.749 |
PHKG1 |
0.752 | -0.048 | -3 | 0.790 |
TLK1 |
0.751 | 0.013 | -2 | 0.845 |
PAK1 |
0.751 | -0.044 | -2 | 0.711 |
CAMK2A |
0.751 | -0.034 | 2 | 0.646 |
MNK1 |
0.751 | -0.016 | -2 | 0.733 |
MAPKAPK2 |
0.751 | -0.055 | -3 | 0.679 |
SMG1 |
0.751 | -0.027 | 1 | 0.718 |
MELK |
0.751 | -0.043 | -3 | 0.755 |
PAK3 |
0.751 | -0.059 | -2 | 0.704 |
GRK2 |
0.750 | -0.007 | -2 | 0.688 |
AURB |
0.750 | -0.013 | -2 | 0.601 |
SSTK |
0.750 | 0.018 | 4 | 0.800 |
CAMK4 |
0.750 | -0.099 | -3 | 0.778 |
NEK2 |
0.749 | -0.055 | 2 | 0.748 |
MEK1 |
0.749 | -0.095 | 2 | 0.749 |
PLK3 |
0.749 | -0.036 | 2 | 0.665 |
CLK4 |
0.749 | -0.009 | -3 | 0.722 |
CDK13 |
0.749 | -0.009 | 1 | 0.534 |
PLK4 |
0.749 | -0.009 | 2 | 0.614 |
HIPK2 |
0.749 | 0.026 | 1 | 0.546 |
JNK2 |
0.749 | 0.018 | 1 | 0.510 |
PERK |
0.749 | -0.024 | -2 | 0.815 |
PRP4 |
0.748 | 0.081 | -3 | 0.892 |
SGK3 |
0.748 | -0.003 | -3 | 0.730 |
HIPK1 |
0.748 | 0.019 | 1 | 0.648 |
CLK2 |
0.748 | 0.038 | -3 | 0.707 |
ERK1 |
0.748 | 0.021 | 1 | 0.508 |
GSK3A |
0.747 | 0.079 | 4 | 0.563 |
MARK3 |
0.747 | -0.027 | 4 | 0.765 |
PKACB |
0.747 | -0.009 | -2 | 0.628 |
MST3 |
0.747 | 0.059 | 2 | 0.749 |
P38G |
0.747 | 0.021 | 1 | 0.428 |
CK1D |
0.747 | 0.056 | -3 | 0.569 |
CDK3 |
0.746 | 0.040 | 1 | 0.447 |
MSK2 |
0.746 | -0.066 | -3 | 0.705 |
CDK18 |
0.746 | 0.000 | 1 | 0.483 |
MSK1 |
0.746 | -0.027 | -3 | 0.708 |
MEKK1 |
0.746 | -0.037 | 1 | 0.766 |
CLK1 |
0.746 | -0.015 | -3 | 0.689 |
BRSK1 |
0.746 | -0.059 | -3 | 0.748 |
IRAK4 |
0.745 | -0.013 | 1 | 0.786 |
MARK2 |
0.745 | -0.036 | 4 | 0.737 |
BRSK2 |
0.745 | -0.065 | -3 | 0.771 |
AURA |
0.745 | -0.007 | -2 | 0.579 |
MEK5 |
0.745 | -0.033 | 2 | 0.751 |
HRI |
0.745 | -0.072 | -2 | 0.824 |
MYLK4 |
0.745 | -0.051 | -2 | 0.705 |
PAK2 |
0.745 | -0.045 | -2 | 0.688 |
CDK7 |
0.745 | -0.045 | 1 | 0.557 |
NEK5 |
0.745 | 0.028 | 1 | 0.779 |
P38B |
0.744 | 0.020 | 1 | 0.513 |
MPSK1 |
0.744 | 0.043 | 1 | 0.725 |
DNAPK |
0.744 | -0.019 | 1 | 0.676 |
P38A |
0.744 | 0.000 | 1 | 0.585 |
GRK3 |
0.744 | 0.019 | -2 | 0.657 |
DCAMKL1 |
0.744 | -0.017 | -3 | 0.737 |
ZAK |
0.744 | -0.020 | 1 | 0.735 |
SIK |
0.744 | -0.062 | -3 | 0.710 |
WNK4 |
0.744 | -0.043 | -2 | 0.784 |
PRKX |
0.743 | 0.008 | -3 | 0.640 |
GSK3B |
0.743 | 0.053 | 4 | 0.557 |
EEF2K |
0.743 | 0.087 | 3 | 0.821 |
CK1A2 |
0.743 | 0.049 | -3 | 0.563 |
PRKD3 |
0.743 | -0.075 | -3 | 0.684 |
SNRK |
0.743 | -0.102 | 2 | 0.665 |
CDK12 |
0.742 | -0.008 | 1 | 0.510 |
CDK2 |
0.742 | -0.019 | 1 | 0.590 |
ERK2 |
0.741 | -0.016 | 1 | 0.563 |
PAK6 |
0.741 | -0.025 | -2 | 0.611 |
CHK1 |
0.741 | -0.114 | -3 | 0.777 |
PASK |
0.741 | 0.002 | -3 | 0.841 |
AKT2 |
0.740 | -0.018 | -3 | 0.633 |
TAO3 |
0.740 | 0.028 | 1 | 0.739 |
DYRK1A |
0.740 | -0.006 | 1 | 0.640 |
PKCT |
0.739 | -0.036 | 2 | 0.688 |
BRAF |
0.739 | -0.063 | -4 | 0.770 |
CDK17 |
0.739 | -0.015 | 1 | 0.430 |
PINK1 |
0.738 | -0.043 | 1 | 0.759 |
CAMK1G |
0.738 | -0.068 | -3 | 0.704 |
P38D |
0.738 | 0.034 | 1 | 0.450 |
MARK1 |
0.737 | -0.065 | 4 | 0.788 |
TTBK1 |
0.736 | -0.078 | 2 | 0.581 |
HIPK3 |
0.736 | -0.012 | 1 | 0.645 |
PKCE |
0.736 | 0.007 | 2 | 0.670 |
CDK9 |
0.736 | -0.046 | 1 | 0.542 |
GCK |
0.736 | 0.086 | 1 | 0.773 |
DYRK3 |
0.736 | 0.004 | 1 | 0.671 |
NEK8 |
0.735 | -0.015 | 2 | 0.760 |
PDK1 |
0.734 | 0.018 | 1 | 0.742 |
NEK11 |
0.734 | -0.031 | 1 | 0.743 |
MINK |
0.734 | 0.073 | 1 | 0.783 |
CDK14 |
0.734 | -0.011 | 1 | 0.532 |
GAK |
0.734 | -0.002 | 1 | 0.736 |
MST2 |
0.734 | 0.021 | 1 | 0.768 |
DCAMKL2 |
0.734 | -0.063 | -3 | 0.751 |
PIM2 |
0.734 | -0.065 | -3 | 0.694 |
SMMLCK |
0.733 | -0.064 | -3 | 0.779 |
DRAK1 |
0.733 | -0.100 | 1 | 0.664 |
TNIK |
0.733 | 0.069 | 3 | 0.822 |
DYRK4 |
0.733 | -0.013 | 1 | 0.536 |
CK2A2 |
0.733 | 0.014 | 1 | 0.635 |
PKACA |
0.733 | -0.019 | -2 | 0.583 |
HGK |
0.732 | 0.042 | 3 | 0.820 |
PKCI |
0.732 | -0.038 | 2 | 0.696 |
AKT1 |
0.731 | -0.020 | -3 | 0.654 |
MAPKAPK5 |
0.731 | -0.117 | -3 | 0.668 |
PHKG2 |
0.731 | -0.070 | -3 | 0.743 |
CDK10 |
0.730 | -0.015 | 1 | 0.517 |
VRK1 |
0.730 | 0.023 | 2 | 0.779 |
JNK1 |
0.730 | 0.004 | 1 | 0.489 |
DYRK1B |
0.730 | -0.030 | 1 | 0.552 |
PLK2 |
0.729 | -0.011 | -3 | 0.801 |
TAO2 |
0.729 | -0.037 | 2 | 0.764 |
CDK16 |
0.729 | -0.014 | 1 | 0.448 |
ERK7 |
0.729 | -0.007 | 2 | 0.508 |
HPK1 |
0.729 | 0.065 | 1 | 0.773 |
KHS2 |
0.728 | 0.105 | 1 | 0.792 |
MAP3K15 |
0.728 | -0.000 | 1 | 0.715 |
CK2A1 |
0.728 | 0.032 | 1 | 0.617 |
KHS1 |
0.727 | 0.080 | 1 | 0.785 |
NEK4 |
0.727 | -0.030 | 1 | 0.783 |
DAPK3 |
0.727 | -0.022 | -3 | 0.759 |
LRRK2 |
0.726 | -0.037 | 2 | 0.768 |
TAK1 |
0.726 | -0.012 | 1 | 0.788 |
TTK |
0.726 | 0.091 | -2 | 0.825 |
IRAK1 |
0.725 | -0.165 | -1 | 0.687 |
MEKK6 |
0.725 | -0.034 | 1 | 0.741 |
LKB1 |
0.725 | -0.064 | -3 | 0.855 |
MAK |
0.724 | 0.038 | -2 | 0.712 |
CAMK1D |
0.724 | -0.073 | -3 | 0.629 |
HASPIN |
0.724 | 0.041 | -1 | 0.656 |
CAMKK1 |
0.724 | -0.127 | -2 | 0.652 |
ROCK2 |
0.724 | 0.006 | -3 | 0.754 |
P70S6K |
0.724 | -0.087 | -3 | 0.650 |
NEK1 |
0.723 | -0.015 | 1 | 0.773 |
DAPK1 |
0.723 | -0.007 | -3 | 0.745 |
PDHK3_TYR |
0.722 | 0.062 | 4 | 0.903 |
STK33 |
0.721 | -0.059 | 2 | 0.551 |
PAK5 |
0.721 | -0.055 | -2 | 0.558 |
CDK6 |
0.721 | -0.009 | 1 | 0.510 |
BUB1 |
0.721 | -0.003 | -5 | 0.354 |
MST1 |
0.721 | -0.031 | 1 | 0.767 |
PKN1 |
0.721 | -0.060 | -3 | 0.664 |
SGK1 |
0.721 | -0.017 | -3 | 0.558 |
PAK4 |
0.720 | -0.048 | -2 | 0.572 |
CK1A |
0.720 | 0.060 | -3 | 0.487 |
AKT3 |
0.720 | -0.022 | -3 | 0.573 |
SLK |
0.719 | -0.018 | -2 | 0.645 |
LOK |
0.719 | -0.040 | -2 | 0.692 |
OSR1 |
0.719 | 0.039 | 2 | 0.720 |
CAMKK2 |
0.719 | -0.122 | -2 | 0.649 |
CHK2 |
0.718 | -0.052 | -3 | 0.572 |
MRCKA |
0.718 | -0.033 | -3 | 0.708 |
YSK1 |
0.718 | -0.036 | 2 | 0.740 |
MOK |
0.717 | 0.009 | 1 | 0.677 |
MRCKB |
0.717 | -0.034 | -3 | 0.689 |
PDHK4_TYR |
0.717 | 0.096 | 2 | 0.757 |
CDK4 |
0.716 | -0.025 | 1 | 0.502 |
MAP2K6_TYR |
0.715 | 0.069 | -1 | 0.823 |
BMPR2_TYR |
0.714 | 0.048 | -1 | 0.827 |
CAMK1A |
0.713 | -0.068 | -3 | 0.595 |
MAP2K4_TYR |
0.713 | 0.021 | -1 | 0.819 |
TESK1_TYR |
0.713 | -0.064 | 3 | 0.816 |
PDHK1_TYR |
0.713 | 0.057 | -1 | 0.827 |
RIPK2 |
0.712 | -0.150 | 1 | 0.695 |
MEK2 |
0.712 | -0.127 | 2 | 0.742 |
MAP2K7_TYR |
0.711 | -0.034 | 2 | 0.763 |
PKMYT1_TYR |
0.710 | -0.075 | 3 | 0.780 |
MYO3B |
0.709 | 0.019 | 2 | 0.757 |
ROCK1 |
0.709 | -0.011 | -3 | 0.709 |
CK1G3 |
0.709 | 0.103 | -3 | 0.446 |
DMPK1 |
0.708 | -0.031 | -3 | 0.709 |
PKG1 |
0.708 | -0.040 | -2 | 0.548 |
MYO3A |
0.707 | 0.012 | 1 | 0.795 |
ROS1 |
0.706 | 0.028 | 3 | 0.717 |
LIMK2_TYR |
0.706 | -0.032 | -3 | 0.877 |
PINK1_TYR |
0.706 | -0.092 | 1 | 0.764 |
EPHA6 |
0.705 | -0.017 | -1 | 0.811 |
ALPHAK3 |
0.705 | -0.006 | -1 | 0.710 |
PBK |
0.705 | -0.071 | 1 | 0.654 |
YANK3 |
0.704 | -0.041 | 2 | 0.344 |
TYK2 |
0.703 | -0.030 | 1 | 0.758 |
RET |
0.703 | -0.039 | 1 | 0.757 |
NEK3 |
0.703 | -0.118 | 1 | 0.724 |
TXK |
0.703 | 0.040 | 1 | 0.732 |
TYRO3 |
0.701 | -0.032 | 3 | 0.733 |
FGR |
0.701 | -0.013 | 1 | 0.749 |
EPHB4 |
0.701 | -0.020 | -1 | 0.781 |
ASK1 |
0.701 | -0.062 | 1 | 0.701 |
JAK2 |
0.701 | -0.020 | 1 | 0.749 |
CSF1R |
0.701 | -0.004 | 3 | 0.710 |
LIMK1_TYR |
0.700 | -0.123 | 2 | 0.775 |
CRIK |
0.700 | -0.053 | -3 | 0.652 |
YES1 |
0.699 | -0.005 | -1 | 0.782 |
INSRR |
0.699 | 0.004 | 3 | 0.685 |
FER |
0.698 | -0.027 | 1 | 0.766 |
SBK |
0.698 | -0.076 | -3 | 0.498 |
TAO1 |
0.698 | -0.051 | 1 | 0.698 |
BLK |
0.697 | 0.047 | -1 | 0.773 |
LCK |
0.697 | 0.024 | -1 | 0.778 |
DDR1 |
0.697 | -0.087 | 4 | 0.829 |
MST1R |
0.697 | -0.086 | 3 | 0.727 |
ABL2 |
0.697 | -0.010 | -1 | 0.732 |
HCK |
0.696 | -0.010 | -1 | 0.769 |
BIKE |
0.695 | -0.060 | 1 | 0.609 |
JAK3 |
0.695 | -0.061 | 1 | 0.715 |
KDR |
0.695 | 0.006 | 3 | 0.681 |
TNNI3K_TYR |
0.695 | -0.022 | 1 | 0.781 |
CK1G2 |
0.694 | 0.080 | -3 | 0.540 |
KIT |
0.694 | -0.016 | 3 | 0.713 |
STLK3 |
0.694 | -0.055 | 1 | 0.712 |
EPHB1 |
0.694 | -0.028 | 1 | 0.744 |
JAK1 |
0.693 | -0.001 | 1 | 0.707 |
ITK |
0.692 | -0.046 | -1 | 0.734 |
TNK2 |
0.692 | -0.053 | 3 | 0.665 |
SRMS |
0.692 | -0.037 | 1 | 0.753 |
FYN |
0.691 | 0.032 | -1 | 0.763 |
FLT3 |
0.691 | -0.056 | 3 | 0.726 |
WEE1_TYR |
0.691 | -0.009 | -1 | 0.687 |
FLT1 |
0.691 | 0.018 | -1 | 0.778 |
ABL1 |
0.690 | -0.048 | -1 | 0.725 |
PDGFRB |
0.690 | -0.085 | 3 | 0.735 |
TNK1 |
0.690 | -0.037 | 3 | 0.718 |
EPHB3 |
0.690 | -0.058 | -1 | 0.766 |
EPHA4 |
0.690 | -0.058 | 2 | 0.651 |
BMX |
0.689 | -0.021 | -1 | 0.659 |
MET |
0.689 | -0.023 | 3 | 0.691 |
FGFR2 |
0.689 | -0.086 | 3 | 0.713 |
TEC |
0.689 | -0.027 | -1 | 0.660 |
EPHB2 |
0.688 | -0.049 | -1 | 0.761 |
BTK |
0.686 | -0.079 | -1 | 0.698 |
PTK6 |
0.686 | -0.054 | -1 | 0.669 |
FRK |
0.685 | -0.025 | -1 | 0.768 |
MERTK |
0.685 | -0.045 | 3 | 0.676 |
ALK |
0.685 | -0.045 | 3 | 0.644 |
DDR2 |
0.685 | -0.012 | 3 | 0.664 |
PDGFRA |
0.685 | -0.094 | 3 | 0.727 |
TEK |
0.684 | -0.101 | 3 | 0.671 |
NEK10_TYR |
0.683 | -0.091 | 1 | 0.654 |
AXL |
0.683 | -0.096 | 3 | 0.687 |
SYK |
0.683 | 0.055 | -1 | 0.739 |
FGFR1 |
0.683 | -0.112 | 3 | 0.682 |
EPHA7 |
0.683 | -0.058 | 2 | 0.668 |
FGFR3 |
0.682 | -0.049 | 3 | 0.689 |
LYN |
0.682 | -0.040 | 3 | 0.655 |
NTRK1 |
0.681 | -0.079 | -1 | 0.756 |
AAK1 |
0.681 | -0.035 | 1 | 0.502 |
ERBB2 |
0.681 | -0.073 | 1 | 0.691 |
PTK2 |
0.681 | 0.021 | -1 | 0.767 |
LTK |
0.680 | -0.073 | 3 | 0.659 |
INSR |
0.680 | -0.080 | 3 | 0.673 |
SRC |
0.680 | -0.016 | -1 | 0.753 |
FLT4 |
0.679 | -0.085 | 3 | 0.675 |
NTRK3 |
0.677 | -0.068 | -1 | 0.717 |
EGFR |
0.677 | -0.040 | 1 | 0.594 |
EPHA3 |
0.677 | -0.105 | 2 | 0.640 |
EPHA1 |
0.676 | -0.100 | 3 | 0.672 |
YANK2 |
0.675 | -0.041 | 2 | 0.356 |
NTRK2 |
0.675 | -0.125 | 3 | 0.657 |
MATK |
0.674 | -0.078 | -1 | 0.660 |
EPHA5 |
0.674 | -0.065 | 2 | 0.642 |
EPHA8 |
0.674 | -0.060 | -1 | 0.751 |
FGFR4 |
0.672 | -0.043 | -1 | 0.708 |
IGF1R |
0.671 | -0.040 | 3 | 0.614 |
PTK2B |
0.671 | -0.068 | -1 | 0.706 |
CSK |
0.669 | -0.096 | 2 | 0.682 |
ZAP70 |
0.668 | 0.060 | -1 | 0.663 |
ERBB4 |
0.668 | -0.024 | 1 | 0.609 |
EPHA2 |
0.666 | -0.039 | -1 | 0.726 |
MUSK |
0.661 | -0.099 | 1 | 0.574 |
FES |
0.651 | -0.089 | -1 | 0.642 |