Motif 246 (n=283)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2778 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A1W2PPC1 | PRR33 | S70 | ochoa | Proline rich 33 | None |
| C9J069 | AJM1 | S512 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| O00267 | SUPT5H | S804 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14497 | ARID1A | S301 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14531 | DPYSL4 | S542 | ochoa | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| O14654 | IRS4 | S863 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14757 | CHEK1 | S331 | ochoa | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| O15211 | RGL2 | S589 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15541 | RNF113A | S46 | ochoa | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| O43237 | DYNC1LI2 | S389 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
| O43896 | KIF1C | S983 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60732 | MAGEC1 | S99 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
| O60825 | PFKFB2 | S471 | ochoa | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O75369 | FLNB | S846 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1671 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75385 | ULK1 | S781 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O94762 | RECQL5 | S858 | ochoa | ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5) | DNA helicase that plays an important role in DNA replication, transcription and repair (PubMed:20643585, PubMed:22973052, PubMed:28100692). Probably unwinds DNA in a 3'-5' direction (Probable) (PubMed:28100692). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability (PubMed:20231364). Also associates with POLR1A and enforces the stability of ribosomal DNA arrays (PubMed:27502483). Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress (PubMed:22013166). Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis (PubMed:28575661). Required for efficient DNA repair, including repair of inter-strand cross-links (PubMed:23715498). Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA (PubMed:28100692). {ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20643585, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22973052, ECO:0000269|PubMed:23715498, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:27502483, ECO:0000269|PubMed:28100692, ECO:0000269|PubMed:28575661, ECO:0000305|PubMed:28100692}. |
| O94804 | STK10 | S374 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94986 | CEP152 | S133 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95049 | TJP3 | S360 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95071 | UBR5 | S621 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95359 | TACC2 | S1946 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P00533 | EGFR | S1071 | ochoa|psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04004 | VTN | S130 | ochoa | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P04275 | VWF | S1613 | psp | von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| P04626 | ERBB2 | S1083 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04637 | TP53 | S371 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P05129 | PRKCG | S664 | ochoa | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P07910 | HNRNPC | Y126 | psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08651 | NFIC | S284 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P10636 | MAPT | S214 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11137 | MAP2 | S738 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P12980 | LYL1 | S51 | ochoa | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
| P19878 | NCF2 | S332 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P21333 | FLNA | S2531 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22681 | CBL | S669 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P28324 | ELK4 | S215 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P29353 | SHC1 | S426 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P29353 | SHC1 | Y427 | ochoa|psp | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30260 | CDC27 | T356 | ochoa | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| P30414 | NKTR | S325 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30622 | CLIP1 | S160 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P35269 | GTF2F1 | S399 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P38159 | RBMX | Y134 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S135 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S174 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P40763 | STAT3 | S727 | ochoa|psp | Signal transducer and activator of transcription 3 (Acute-phase response factor) | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}. |
| P41182 | BCL6 | S343 | ochoa|psp | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P42331 | ARHGAP25 | S521 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P43403 | ZAP70 | S520 | psp | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46013 | MKI67 | S538 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P47974 | ZFP36L2 | S430 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P49790 | NUP153 | T222 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49848 | TAF6 | S639 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P50570 | DNM2 | S762 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P51798 | CLCN7 | S61 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P54132 | BLM | S502 | psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54253 | ATXN1 | S253 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
| P78312 | FAM193A | S737 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78332 | RBM6 | S44 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78337 | PITX1 | S48 | ochoa | Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}. |
| P78411 | IRX5 | S248 | ochoa | Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) | Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}. |
| P78559 | MAP1A | S1762 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S2424 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82094 | TMF1 | S414 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P85037 | FOXK1 | Y205 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P85037 | FOXK1 | S236 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01973 | ROR1 | Y789 | ochoa | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000269|PubMed:25029443, ECO:0000269|PubMed:27162350, ECO:0000269|PubMed:36949068}. |
| Q02218 | OGDH | S871 | ochoa | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050, PubMed:35272141). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:25210035, ECO:0000269|PubMed:28435050, ECO:0000269|PubMed:29211711, ECO:0000303|PubMed:25210035}. |
| Q07157 | TJP1 | S1111 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S1142 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08043 | ACTN3 | S321 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08499 | PDE4D | S146 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q09666 | AHNAK | S4900 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0JRZ9 | FCHO2 | S478 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12834 | CDC20 | S153 | psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Q13177 | PAK2 | S24 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13237 | PRKG2 | S110 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13541 | EIF4EBP1 | S83 | ochoa|psp | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q14004 | CDK13 | S507 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14126 | DSG2 | S939 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14194 | CRMP1 | S542 | ochoa | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q14315 | FLNC | S868 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1540 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14315 | FLNC | S1637 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14432 | PDE3A | S593 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14493 | SLBP | S20 | ochoa|psp | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:P97440, ECO:0000269|PubMed:12588979, ECO:0000269|PubMed:19155325, ECO:0000269|PubMed:8957003, ECO:0000269|PubMed:9049306}. |
| Q14517 | FAT1 | S4476 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14641 | INSL4 | S103 | ochoa | Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain] | May play an important role in trophoblast development and in the regulation of bone formation. |
| Q147X3 | NAA30 | S134 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14938 | NFIX | S301 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15036 | SNX17 | S428 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15349 | RPS6KA2 | S377 | ochoa | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15418 | RPS6KA1 | S380 | ochoa|psp | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15643 | TRIP11 | S1859 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q15678 | PTPN14 | S531 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q16204 | CCDC6 | Y393 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16555 | DPYSL2 | S542 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q16625 | OCLN | S358 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16665 | HIF1A | S576 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16799 | RTN1 | S560 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q27J81 | INF2 | S1083 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2KJY2 | KIF26B | S975 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2PPJ7 | RALGAPA2 | S701 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q3B726 | POLR1F | S304 | ochoa | DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| Q3KQU3 | MAP7D1 | S89 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KQU3 | MAP7D1 | S473 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4AC94 | C2CD3 | S1609 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4AC94 | C2CD3 | S2114 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q5HYK7 | SH3D19 | S148 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5JRA6 | MIA3 | S1691 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5M775 | SPECC1 | S826 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5SZD1 | C6orf141 | S25 | ochoa | Uncharacterized protein C6orf141 | None |
| Q5T0W9 | FAM83B | S920 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T0Z8 | C6orf132 | S971 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T200 | ZC3H13 | S338 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T5P2 | KIAA1217 | S1027 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TCZ1 | SH3PXD2A | S639 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5THJ4 | VPS13D | S1707 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VT52 | RPRD2 | S596 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | S745 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q66K74 | MAP1S | S651 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q69YQ0 | SPECC1L | S887 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6EMK4 | VASN | S647 | ochoa | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q6N043 | ZNF280D | S527 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P3S6 | FBXO42 | S552 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6P9F7 | LRRC8B | S192 | ochoa | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}. |
| Q6PGN9 | PSRC1 | S122 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6W2J9 | BCOR | S586 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6WCQ1 | MPRIP | S365 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6XZF7 | DNMBP | T1384 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZRI6 | C15orf39 | S455 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRS2 | SRCAP | S2955 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRV2 | FAM83H | S514 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZW31 | SYDE1 | S231 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70UQ0 | IKBIP | S24 | ochoa | Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein) | Target of p53/TP53 with pro-apoptotic function. {ECO:0000269|PubMed:15389287}. |
| Q7Z2Z1 | TICRR | S1359 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z5J4 | RAI1 | S642 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5L9 | IRF2BP2 | S381 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z5R6 | APBB1IP | S531 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q7Z6J9 | TSEN54 | S235 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q86UE4 | MTDH | S494 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UU1 | PHLDB1 | S533 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86VP1 | TAX1BP1 | S666 | ochoa|psp | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VP3 | PACS2 | S329 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86YD1 | PTOV1 | S36 | ochoa|psp | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
| Q86YV0 | RASAL3 | S819 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q86YV5 | PRAG1 | S826 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IX07 | ZFPM1 | S914 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY63 | AMOTL1 | S906 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IY92 | SLX4 | S1333 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IZD4 | DCP1B | S227 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8IZW8 | TNS4 | S364 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8IZW8 | TNS4 | S404 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N122 | RPTOR | S859 | ochoa|psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N1G1 | REXO1 | S365 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N1I0 | DOCK4 | S1769 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8NCN4 | RNF169 | S409 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8ND24 | RNF214 | S516 | ochoa | RING finger protein 214 | None |
| Q8ND76 | CCNY | S71 | ochoa|psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NFH5 | NUP35 | S58 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8NHM5 | KDM2B | S1031 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8NHY3 | GAS2L2 | S662 | ochoa | GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). {ECO:0000250|UniProtKB:Q5SSG4, ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}. |
| Q8TBC3 | SHKBP1 | S662 | ochoa | SH3KBP1-binding protein 1 (SETA-binding protein 1) | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}. |
| Q8TD16 | BICD2 | S605 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TEW0 | PARD3 | S892 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF72 | SHROOM3 | S963 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WVM8 | SCFD1 | S316 | ochoa|psp | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WWM7 | ATXN2L | S396 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWM7 | ATXN2L | S406 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92502 | STARD8 | S486 | ochoa | StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) | Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}. |
| Q92613 | JADE3 | S548 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92615 | LARP4B | S718 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92766 | RREB1 | S1653 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92870 | APBB2 | S44 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q92918 | MAP4K1 | S454 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92945 | KHSRP | S200 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q93052 | LPP | S148 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q93052 | LPP | S151 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q93052 | LPP | Y244 | ochoa|psp | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969V6 | MRTFA | S119 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AP7 | ESAM | S338 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96E39 | RBMXL1 | Y134 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S135 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96EV8 | DTNBP1 | S298 | ochoa | Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}. |
| Q96HB5 | CCDC120 | S296 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96I24 | FUBP3 | S457 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96IF1 | AJUBA | S119 | ochoa|psp | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96L73 | NSD1 | S961 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MG2 | JSRP1 | S51 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96MG7 | NSMCE3 | S60 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96NU1 | SAMD11 | S418 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96PC5 | MIA2 | S1186 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PU5 | NEDD4L | S366 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96PY6 | NEK1 | S299 | psp | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RT6 | CTAGE1 | S547 | ochoa | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
| Q96RY5 | CRAMP1 | S75 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99501 | GAS2L1 | S316 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99661 | KIF2C | S115 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99700 | ATXN2 | S565 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99700 | ATXN2 | S674 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99741 | CDC6 | S88 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BRK4 | LZTS2 | S241 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BSQ5 | CCM2 | S252 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BTA9 | WAC | S470 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTL3 | RAMAC | S86 | ochoa | RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM) | Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). {ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871}. |
| Q9BU76 | MMTAG2 | S233 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BUL5 | PHF23 | S124 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BW04 | SARG | S438 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX63 | BRIP1 | S1029 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXB4 | OSBPL11 | S194 | ochoa | Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:23028956, ECO:0000269|PubMed:39106189}. |
| Q9BXK1 | KLF16 | S226 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BY89 | KIAA1671 | S518 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYG3 | NIFK | S247 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9C0B0 | UNK | S367 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0D6 | FHDC1 | S546 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9C0H2 | TTYH3 | S496 | ochoa | Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q6P5F7, ECO:0000269|PubMed:15010458}. |
| Q9C0H5 | ARHGAP39 | S445 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H3D4 | TP63 | S477 | ochoa|psp | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H4Z2 | ZNF335 | S989 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H694 | BICC1 | S766 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9HB58 | SP110 | S157 | ochoa | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). |
| Q9HBD1 | RC3H2 | S562 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NPB6 | PARD6A | S283 | ochoa | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}. |
| Q9NQC3 | RTN4 | S124 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQC7 | CYLD | S418 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NQC7 | CYLD | S439 | psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NQS7 | INCENP | S296 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRA0 | SPHK2 | S419 | psp | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| Q9NWH9 | SLTM | S882 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWH9 | SLTM | S929 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NX61 | TMEM161A | S69 | ochoa | Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) | May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}. |
| Q9NXR1 | NDE1 | S225 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9NYB9 | ABI2 | S196 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYD6 | HOXC10 | S115 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NZ09 | UBAP1 | S128 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
| Q9NZJ0 | DTL | S446 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P0K7 | RAI14 | Y387 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P1Y5 | CAMSAP3 | S876 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P206 | NHSL3 | S527 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P266 | JCAD | S911 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P273 | TENM3 | S199 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9UBW5 | BIN2 | S382 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UBW5 | BIN2 | S440 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGP4 | LIMD1 | Y179 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UIF9 | BAZ2A | S1214 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UIW2 | PLXNA1 | S1614 | ochoa | Plexin-A1 (Semaphorin receptor NOV) | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. {ECO:0000250|UniProtKB:P70206}. |
| Q9UJM3 | ERRFI1 | S265 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UJV9 | DDX41 | S302 | ochoa | Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog) | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:34473945). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses (PubMed:23222971). Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1 (PubMed:25704810). Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity (PubMed:35613581). In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:35613581). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing (PubMed:33650667). Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability (PubMed:36229594). Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis (PubMed:36229594, PubMed:36780110). {ECO:0000250|UniProtKB:Q91VN6, ECO:0000269|PubMed:23222971, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:25920683, ECO:0000269|PubMed:33650667, ECO:0000269|PubMed:34473945, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:36229594, ECO:0000269|PubMed:36780110}. |
| Q9UKE5 | TNIK | S574 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULI0 | ATAD2B | S35 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULU4 | ZMYND8 | S53 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMS6 | SYNPO2 | S770 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UNY4 | TTF2 | S244 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPT8 | ZC3H4 | S159 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S333 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB3 | CTNND2 | S201 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y232 | CDYL | S214 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y2K6 | USP20 | S390 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y2U5 | MAP3K2 | S331 | ochoa | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
| Q9Y2U8 | LEMD3 | S185 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3M8 | STARD13 | S577 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y4B5 | MTCL1 | S209 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4B5 | MTCL1 | S231 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S706 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S1181 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6D6 | ARFGEF1 | S1566 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6J0 | CABIN1 | S1803 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6Y8 | SEC23IP | S126 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| P62979 | RPS27A | S134 | Sugiyama | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| Q8N0Y7 | PGAM4 | S137 | Sugiyama | Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) | None |
| O60479 | DLX3 | S138 | SIGNOR|iPTMNet|EPSD | Homeobox protein DLX-3 | Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}. |
| Q96EP5 | DAZAP1 | S204 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q05513 | PRKCZ | S486 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| P17096 | HMGA1 | S64 | SIGNOR | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Q12851 | MAP4K2 | S475 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q8IVH8 | MAP4K3 | S549 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q9C0C2 | TNKS1BP1 | S77 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P26006 | ITGA3 | S898 | Sugiyama | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. {ECO:0000269|PubMed:32487760}. |
| Q86Z02 | HIPK1 | S342 | Sugiyama | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q9H2X6 | HIPK2 | S351 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H422 | HIPK3 | S349 | Sugiyama | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000016 | 4.804 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.000039 | 4.407 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000049 | 4.311 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.000349 | 3.457 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.000428 | 3.369 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.000381 | 3.420 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.000518 | 3.286 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.000544 | 3.264 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.000618 | 3.209 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.000621 | 3.207 |
| R-HSA-162582 | Signal Transduction | 0.000927 | 3.033 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.001035 | 2.985 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.001063 | 2.973 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.001108 | 2.956 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.001359 | 2.867 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.001359 | 2.867 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001757 | 2.755 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.001757 | 2.755 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.001607 | 2.794 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.001778 | 2.750 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.001659 | 2.780 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.001495 | 2.825 |
| R-HSA-201556 | Signaling by ALK | 0.001603 | 2.795 |
| R-HSA-373755 | Semaphorin interactions | 0.001991 | 2.701 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.001945 | 2.711 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.001991 | 2.701 |
| R-HSA-8848021 | Signaling by PTK6 | 0.001991 | 2.701 |
| R-HSA-6804754 | Regulation of TP53 Expression | 0.002466 | 2.608 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.002608 | 2.584 |
| R-HSA-199991 | Membrane Trafficking | 0.002579 | 2.589 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.002868 | 2.542 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.003191 | 2.496 |
| R-HSA-9842663 | Signaling by LTK | 0.003191 | 2.496 |
| R-HSA-75153 | Apoptotic execution phase | 0.003184 | 2.497 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.003568 | 2.448 |
| R-HSA-166520 | Signaling by NTRKs | 0.003516 | 2.454 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.003762 | 2.425 |
| R-HSA-2559583 | Cellular Senescence | 0.003656 | 2.437 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.003777 | 2.423 |
| R-HSA-68882 | Mitotic Anaphase | 0.004121 | 2.385 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.004251 | 2.371 |
| R-HSA-162587 | HIV Life Cycle | 0.004926 | 2.308 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.005137 | 2.289 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.005418 | 2.266 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.005247 | 2.280 |
| R-HSA-6806834 | Signaling by MET | 0.005618 | 2.250 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.006299 | 2.201 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.006292 | 2.201 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.006292 | 2.201 |
| R-HSA-109581 | Apoptosis | 0.005880 | 2.231 |
| R-HSA-177929 | Signaling by EGFR | 0.006448 | 2.191 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.006573 | 2.182 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.006820 | 2.166 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.006863 | 2.163 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.007288 | 2.137 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.007666 | 2.115 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.007666 | 2.115 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.008646 | 2.063 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.009166 | 2.038 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.011766 | 1.929 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.009695 | 2.013 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.010360 | 1.985 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.010943 | 1.961 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.009695 | 2.013 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.010820 | 1.966 |
| R-HSA-199920 | CREB phosphorylation | 0.011766 | 1.929 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.011157 | 1.952 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.011987 | 1.921 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.012009 | 1.920 |
| R-HSA-1640170 | Cell Cycle | 0.013473 | 1.871 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.014221 | 1.847 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.013094 | 1.883 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.013643 | 1.865 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.014356 | 1.843 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.014612 | 1.835 |
| R-HSA-162906 | HIV Infection | 0.015160 | 1.819 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.014914 | 1.826 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.014914 | 1.826 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.014914 | 1.826 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.015927 | 1.798 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.015159 | 1.819 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.016135 | 1.792 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 0.017848 | 1.748 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 0.017848 | 1.748 |
| R-HSA-444257 | RSK activation | 0.017169 | 1.765 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.017510 | 1.757 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.017510 | 1.757 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.017150 | 1.766 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.018205 | 1.740 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.017169 | 1.765 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.016401 | 1.785 |
| R-HSA-437239 | Recycling pathway of L1 | 0.018205 | 1.740 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.016876 | 1.773 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.020194 | 1.695 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.022625 | 1.645 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.020302 | 1.692 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.022498 | 1.648 |
| R-HSA-5357801 | Programmed Cell Death | 0.022090 | 1.656 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.022819 | 1.642 |
| R-HSA-74749 | Signal attenuation | 0.023424 | 1.630 |
| R-HSA-2586552 | Signaling by Leptin | 0.023424 | 1.630 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.023437 | 1.630 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.024269 | 1.615 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.024269 | 1.615 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.026851 | 1.571 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.026058 | 1.584 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.027792 | 1.556 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.026058 | 1.584 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.024469 | 1.611 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.027753 | 1.557 |
| R-HSA-449147 | Signaling by Interleukins | 0.026203 | 1.582 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.026881 | 1.571 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.027992 | 1.553 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.027992 | 1.553 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.027992 | 1.553 |
| R-HSA-75893 | TNF signaling | 0.029505 | 1.530 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.029505 | 1.530 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.029674 | 1.528 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.030466 | 1.516 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.034262 | 1.465 |
| R-HSA-182971 | EGFR downregulation | 0.029999 | 1.523 |
| R-HSA-354192 | Integrin signaling | 0.034236 | 1.466 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.034262 | 1.465 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.029999 | 1.523 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.034236 | 1.466 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.034262 | 1.465 |
| R-HSA-5693538 | Homology Directed Repair | 0.033684 | 1.473 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.029999 | 1.523 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.032081 | 1.494 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.032207 | 1.492 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.034739 | 1.459 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.034739 | 1.459 |
| R-HSA-68886 | M Phase | 0.032565 | 1.487 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.035379 | 1.451 |
| R-HSA-9672393 | Defective F8 binding to von Willebrand factor | 0.035379 | 1.451 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.035874 | 1.445 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.036465 | 1.438 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.036465 | 1.438 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.036833 | 1.434 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.038031 | 1.420 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.038031 | 1.420 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.038231 | 1.418 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.038231 | 1.418 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.038231 | 1.418 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.042366 | 1.373 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.046660 | 1.331 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.046660 | 1.331 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.046660 | 1.331 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.046101 | 1.336 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.044183 | 1.355 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.042366 | 1.373 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.046660 | 1.331 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.042366 | 1.373 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.041139 | 1.386 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.046660 | 1.331 |
| R-HSA-69481 | G2/M Checkpoints | 0.045194 | 1.345 |
| R-HSA-68877 | Mitotic Prometaphase | 0.039941 | 1.399 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.046660 | 1.331 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.043585 | 1.361 |
| R-HSA-5578768 | Physiological factors | 0.042366 | 1.373 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.042366 | 1.373 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.046660 | 1.331 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.046678 | 1.331 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.048688 | 1.313 |
| R-HSA-190236 | Signaling by FGFR | 0.048775 | 1.312 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 0.052598 | 1.279 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.069511 | 1.158 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.069511 | 1.158 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.069511 | 1.158 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.069511 | 1.158 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 0.069511 | 1.158 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.069511 | 1.158 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.069511 | 1.158 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 0.069511 | 1.158 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.069511 | 1.158 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.069511 | 1.158 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.069511 | 1.158 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.069511 | 1.158 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.069511 | 1.158 |
| R-HSA-9672391 | Defective F8 cleavage by thrombin | 0.069511 | 1.158 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.069511 | 1.158 |
| R-HSA-8875791 | MET activates STAT3 | 0.086123 | 1.065 |
| R-HSA-198745 | Signalling to STAT3 | 0.086123 | 1.065 |
| R-HSA-8941237 | Invadopodia formation | 0.086123 | 1.065 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.102439 | 0.990 |
| R-HSA-74713 | IRS activation | 0.118465 | 0.926 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.118465 | 0.926 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 0.118465 | 0.926 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 0.118465 | 0.926 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 0.134206 | 0.872 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.134206 | 0.872 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.134206 | 0.872 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.134206 | 0.872 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.134206 | 0.872 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.134206 | 0.872 |
| R-HSA-9842640 | Signaling by LTK in cancer | 0.149667 | 0.825 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.149667 | 0.825 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.149667 | 0.825 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.051106 | 1.292 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.164852 | 0.783 |
| R-HSA-112412 | SOS-mediated signalling | 0.164852 | 0.783 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.055696 | 1.254 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.055696 | 1.254 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.055696 | 1.254 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.060426 | 1.219 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.060426 | 1.219 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.179767 | 0.745 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.179767 | 0.745 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.070274 | 1.153 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.070274 | 1.153 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.070274 | 1.153 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.194417 | 0.711 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.075381 | 1.123 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.075381 | 1.123 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.075381 | 1.123 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.075381 | 1.123 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.080603 | 1.094 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.208806 | 0.680 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.208806 | 0.680 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.085933 | 1.066 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.085933 | 1.066 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.096895 | 1.014 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.096895 | 1.014 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.102518 | 0.989 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.236820 | 0.626 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.108228 | 0.966 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.054069 | 1.267 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.250455 | 0.601 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.119891 | 0.921 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.119891 | 0.921 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.119891 | 0.921 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.119891 | 0.921 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.125834 | 0.900 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.125834 | 0.900 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.125834 | 0.900 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.125834 | 0.900 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.131847 | 0.880 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.131847 | 0.880 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.131847 | 0.880 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.131847 | 0.880 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.137923 | 0.860 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.078247 | 1.107 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.144060 | 0.841 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.144060 | 0.841 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.144060 | 0.841 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.156498 | 0.805 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.156498 | 0.805 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.095356 | 1.021 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.098948 | 1.005 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.098948 | 1.005 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.102593 | 0.989 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.106291 | 0.974 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.175508 | 0.756 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.175508 | 0.756 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.110041 | 0.958 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.201368 | 0.696 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.207903 | 0.682 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.207903 | 0.682 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.145915 | 0.836 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.221035 | 0.656 |
| R-HSA-167161 | HIV Transcription Initiation | 0.221035 | 0.656 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.221035 | 0.656 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.234232 | 0.630 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.247473 | 0.606 |
| R-HSA-167172 | Transcription of the HIV genome | 0.158630 | 0.800 |
| R-HSA-72172 | mRNA Splicing | 0.219138 | 0.659 |
| R-HSA-167169 | HIV Transcription Elongation | 0.207903 | 0.682 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.171671 | 0.765 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.171671 | 0.765 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.221757 | 0.654 |
| R-HSA-72086 | mRNA Capping | 0.131847 | 0.880 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.188618 | 0.724 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.135648 | 0.868 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.207903 | 0.682 |
| R-HSA-9646399 | Aggrephagy | 0.207903 | 0.682 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.133557 | 0.874 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.214459 | 0.669 |
| R-HSA-73893 | DNA Damage Bypass | 0.084917 | 1.071 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.208806 | 0.680 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.094143 | 1.026 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.094245 | 1.026 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.071819 | 1.144 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.194417 | 0.711 |
| R-HSA-198203 | PI3K/AKT activation | 0.208806 | 0.680 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.119891 | 0.921 |
| R-HSA-169911 | Regulation of Apoptosis | 0.175508 | 0.756 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.201368 | 0.696 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.091365 | 1.039 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.131847 | 0.880 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.064500 | 1.190 |
| R-HSA-191650 | Regulation of gap junction activity | 0.102439 | 0.990 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.164852 | 0.783 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.065287 | 1.185 |
| R-HSA-190873 | Gap junction degradation | 0.194417 | 0.711 |
| R-HSA-5688426 | Deubiquitination | 0.229588 | 0.639 |
| R-HSA-162592 | Integration of provirus | 0.236820 | 0.626 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.156498 | 0.805 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.051106 | 1.292 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.185005 | 0.733 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.201368 | 0.696 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.180529 | 0.743 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 0.118465 | 0.926 |
| R-HSA-8849473 | PTK6 Expression | 0.164852 | 0.783 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.060426 | 1.219 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.179767 | 0.745 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.236820 | 0.626 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.250455 | 0.601 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.062650 | 1.203 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.156498 | 0.805 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.169129 | 0.772 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.188376 | 0.725 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.221035 | 0.656 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.102439 | 0.990 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.102439 | 0.990 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.119891 | 0.921 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.156498 | 0.805 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.169129 | 0.772 |
| R-HSA-69541 | Stabilization of p53 | 0.201368 | 0.696 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.075381 | 1.123 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.051344 | 1.290 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.098948 | 1.005 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.188376 | 0.725 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.214459 | 0.669 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.221035 | 0.656 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.167235 | 0.777 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.085933 | 1.066 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.156498 | 0.805 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.169129 | 0.772 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.235903 | 0.627 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.078665 | 1.104 |
| R-HSA-69239 | Synthesis of DNA | 0.168960 | 0.772 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.137634 | 0.861 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.086123 | 1.065 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.102439 | 0.990 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.164852 | 0.783 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.179767 | 0.745 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.179767 | 0.745 |
| R-HSA-196025 | Formation of annular gap junctions | 0.179767 | 0.745 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.179767 | 0.745 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.065287 | 1.185 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.194417 | 0.711 |
| R-HSA-5689877 | Josephin domain DUBs | 0.208806 | 0.680 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.208806 | 0.680 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.054069 | 1.267 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.081552 | 1.089 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.162791 | 0.788 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.169129 | 0.772 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.181925 | 0.740 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.117690 | 0.929 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.129522 | 0.888 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.221035 | 0.656 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.247473 | 0.606 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.085933 | 1.066 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.247473 | 0.606 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.247473 | 0.606 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.055696 | 1.254 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.207903 | 0.682 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.247473 | 0.606 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.086283 | 1.064 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.089525 | 1.048 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.102439 | 0.990 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.179767 | 0.745 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.194417 | 0.711 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.222939 | 0.652 |
| R-HSA-8851805 | MET activates RAS signaling | 0.250455 | 0.601 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.162791 | 0.788 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.247473 | 0.606 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.062650 | 1.203 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.091365 | 1.039 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.179767 | 0.745 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.179085 | 0.747 |
| R-HSA-165159 | MTOR signalling | 0.227627 | 0.643 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.194417 | 0.711 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.091365 | 1.039 |
| R-HSA-8853659 | RET signaling | 0.181925 | 0.740 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.141814 | 0.848 |
| R-HSA-9612973 | Autophagy | 0.206831 | 0.684 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.125834 | 0.900 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.131847 | 0.880 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.169129 | 0.772 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.203680 | 0.691 |
| R-HSA-73887 | Death Receptor Signaling | 0.200544 | 0.698 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.149667 | 0.825 |
| R-HSA-164843 | 2-LTR circle formation | 0.208806 | 0.680 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.208806 | 0.680 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.236820 | 0.626 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.236820 | 0.626 |
| R-HSA-420029 | Tight junction interactions | 0.108228 | 0.966 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.250455 | 0.601 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.250455 | 0.601 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.144060 | 0.841 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.156498 | 0.805 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.062281 | 1.206 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.169129 | 0.772 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.133557 | 0.874 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.176084 | 0.754 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.113841 | 0.944 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.065642 | 1.183 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.208806 | 0.680 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.169129 | 0.772 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.133557 | 0.874 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.053566 | 1.271 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.169129 | 0.772 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.131074 | 0.882 |
| R-HSA-74160 | Gene expression (Transcription) | 0.200732 | 0.697 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.091365 | 1.039 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.236820 | 0.626 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.145334 | 0.838 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 0.149667 | 0.825 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.051106 | 1.292 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.208806 | 0.680 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.085933 | 1.066 |
| R-HSA-428540 | Activation of RAC1 | 0.236820 | 0.626 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.236820 | 0.626 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.250455 | 0.601 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.250455 | 0.601 |
| R-HSA-69091 | Polymerase switching | 0.250455 | 0.601 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.250455 | 0.601 |
| R-HSA-69109 | Leading Strand Synthesis | 0.250455 | 0.601 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.062281 | 1.206 |
| R-HSA-4086400 | PCP/CE pathway | 0.071401 | 1.146 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.207903 | 0.682 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.214459 | 0.669 |
| R-HSA-69275 | G2/M Transition | 0.167551 | 0.776 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.110041 | 0.958 |
| R-HSA-202433 | Generation of second messenger molecules | 0.207903 | 0.682 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.172721 | 0.763 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.056862 | 1.245 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.105995 | 0.975 |
| R-HSA-983189 | Kinesins | 0.125532 | 0.901 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.186692 | 0.729 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.085933 | 1.066 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.137923 | 0.860 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.102518 | 0.989 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.194041 | 0.712 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.087859 | 1.056 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.204820 | 0.689 |
| R-HSA-9683683 | Maturation of protein E | 0.134206 | 0.872 |
| R-HSA-9694493 | Maturation of protein E | 0.134206 | 0.872 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.134206 | 0.872 |
| R-HSA-164944 | Nef and signal transduction | 0.149667 | 0.825 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.179767 | 0.745 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.222939 | 0.652 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.250455 | 0.601 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.250455 | 0.601 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.250455 | 0.601 |
| R-HSA-9634597 | GPER1 signaling | 0.081552 | 1.089 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.194858 | 0.710 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.064500 | 1.190 |
| R-HSA-450294 | MAP kinase activation | 0.129522 | 0.888 |
| R-HSA-194138 | Signaling by VEGF | 0.246529 | 0.608 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.250200 | 0.602 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.131847 | 0.880 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.137923 | 0.860 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.175508 | 0.756 |
| R-HSA-448424 | Interleukin-17 signaling | 0.167290 | 0.777 |
| R-HSA-5218859 | Regulated Necrosis | 0.158630 | 0.800 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.134206 | 0.872 |
| R-HSA-2028269 | Signaling by Hippo | 0.060426 | 1.219 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 0.179767 | 0.745 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.075381 | 1.123 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.085933 | 1.066 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.084917 | 1.071 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.175508 | 0.756 |
| R-HSA-8875878 | MET promotes cell motility | 0.194858 | 0.710 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.201368 | 0.696 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.079385 | 1.100 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.175508 | 0.756 |
| R-HSA-9664873 | Pexophagy | 0.208806 | 0.680 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.108228 | 0.966 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.065642 | 1.183 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.148626 | 0.828 |
| R-HSA-216083 | Integrin cell surface interactions | 0.203185 | 0.692 |
| R-HSA-198753 | ERK/MAPK targets | 0.080603 | 1.094 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.208806 | 0.680 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.156498 | 0.805 |
| R-HSA-422475 | Axon guidance | 0.090087 | 1.045 |
| R-HSA-2262752 | Cellular responses to stress | 0.127818 | 0.893 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.140355 | 0.853 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.144533 | 0.840 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.065287 | 1.185 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.155295 | 0.809 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.250200 | 0.602 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.210172 | 0.677 |
| R-HSA-5205647 | Mitophagy | 0.169129 | 0.772 |
| R-HSA-9675108 | Nervous system development | 0.131720 | 0.880 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.055696 | 1.254 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.131847 | 0.880 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.250455 | 0.601 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.194858 | 0.710 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.250455 | 0.601 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.096895 | 1.014 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.222939 | 0.652 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.119891 | 0.921 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.057966 | 1.237 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.194417 | 0.711 |
| R-HSA-9833482 | PKR-mediated signaling | 0.212426 | 0.673 |
| R-HSA-9648002 | RAS processing | 0.201368 | 0.696 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.172441 | 0.763 |
| R-HSA-5620971 | Pyroptosis | 0.125834 | 0.900 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.110041 | 0.958 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.181925 | 0.740 |
| R-HSA-1538133 | G0 and Early G1 | 0.150253 | 0.823 |
| R-HSA-373760 | L1CAM interactions | 0.087827 | 1.056 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.181925 | 0.740 |
| R-HSA-9607240 | FLT3 Signaling | 0.214459 | 0.669 |
| R-HSA-8983711 | OAS antiviral response | 0.250455 | 0.601 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.181925 | 0.740 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.254105 | 0.595 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.254105 | 0.595 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.254105 | 0.595 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.254105 | 0.595 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.254105 | 0.595 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.254105 | 0.595 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.254105 | 0.595 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.254105 | 0.595 |
| R-HSA-9675135 | Diseases of DNA repair | 0.254105 | 0.595 |
| R-HSA-9663891 | Selective autophagy | 0.254996 | 0.593 |
| R-HSA-418555 | G alpha (s) signalling events | 0.259218 | 0.586 |
| R-HSA-212436 | Generic Transcription Pathway | 0.259976 | 0.585 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.260739 | 0.584 |
| R-HSA-1500931 | Cell-Cell communication | 0.261676 | 0.582 |
| R-HSA-9853506 | OGDH complex synthesizes succinyl-CoA from 2-OG | 0.263846 | 0.579 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.263846 | 0.579 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.263846 | 0.579 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.263846 | 0.579 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.263846 | 0.579 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.264624 | 0.577 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.267376 | 0.573 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.274012 | 0.562 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.274012 | 0.562 |
| R-HSA-9766229 | Degradation of CDH1 | 0.274012 | 0.562 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.274012 | 0.562 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.276999 | 0.558 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.276999 | 0.558 |
| R-HSA-418457 | cGMP effects | 0.276999 | 0.558 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.276999 | 0.558 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.276999 | 0.558 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.276999 | 0.558 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.276999 | 0.558 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.276999 | 0.558 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.280645 | 0.552 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.281040 | 0.551 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.281914 | 0.550 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.284003 | 0.547 |
| R-HSA-168255 | Influenza Infection | 0.286518 | 0.543 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.288869 | 0.539 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.289918 | 0.538 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.289918 | 0.538 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.289918 | 0.538 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.289918 | 0.538 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.289918 | 0.538 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.289918 | 0.538 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.289918 | 0.538 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.289918 | 0.538 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.289918 | 0.538 |
| R-HSA-416700 | Other semaphorin interactions | 0.289918 | 0.538 |
| R-HSA-446728 | Cell junction organization | 0.292234 | 0.534 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.293740 | 0.532 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.293896 | 0.532 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.293896 | 0.532 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.293896 | 0.532 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.300509 | 0.522 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.302606 | 0.519 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.302606 | 0.519 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.302606 | 0.519 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.302606 | 0.519 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.302606 | 0.519 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.302606 | 0.519 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.302606 | 0.519 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.302606 | 0.519 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.302606 | 0.519 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.302807 | 0.519 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.303499 | 0.518 |
| R-HSA-72649 | Translation initiation complex formation | 0.307112 | 0.513 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.307112 | 0.513 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.313703 | 0.503 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.313703 | 0.503 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.315069 | 0.502 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.315069 | 0.502 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.315069 | 0.502 |
| R-HSA-6783984 | Glycine degradation | 0.315069 | 0.502 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.315069 | 0.502 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.315069 | 0.502 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.315069 | 0.502 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.315069 | 0.502 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.315069 | 0.502 |
| R-HSA-1632852 | Macroautophagy | 0.318013 | 0.498 |
| R-HSA-8939211 | ESR-mediated signaling | 0.318611 | 0.497 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.320281 | 0.494 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.320281 | 0.494 |
| R-HSA-70171 | Glycolysis | 0.323053 | 0.491 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.326843 | 0.486 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.326843 | 0.486 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.327310 | 0.485 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.327310 | 0.485 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.327310 | 0.485 |
| R-HSA-3229121 | Glycogen storage diseases | 0.327310 | 0.485 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.327310 | 0.485 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.332835 | 0.478 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.333388 | 0.477 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.339333 | 0.469 |
| R-HSA-180292 | GAB1 signalosome | 0.339333 | 0.469 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.339333 | 0.469 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.339333 | 0.469 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.339333 | 0.469 |
| R-HSA-3928664 | Ephrin signaling | 0.339333 | 0.469 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.339333 | 0.469 |
| R-HSA-210993 | Tie2 Signaling | 0.339333 | 0.469 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.339333 | 0.469 |
| R-HSA-5358508 | Mismatch Repair | 0.339333 | 0.469 |
| R-HSA-191859 | snRNP Assembly | 0.339915 | 0.469 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.339915 | 0.469 |
| R-HSA-180786 | Extension of Telomeres | 0.339915 | 0.469 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.339915 | 0.469 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.339915 | 0.469 |
| R-HSA-9609690 | HCMV Early Events | 0.345992 | 0.461 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.346422 | 0.460 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.346422 | 0.460 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.346422 | 0.460 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.346422 | 0.460 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.346422 | 0.460 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.346422 | 0.460 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.347498 | 0.459 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.347498 | 0.459 |
| R-HSA-69242 | S Phase | 0.350403 | 0.455 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.351141 | 0.455 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.351141 | 0.455 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.351141 | 0.455 |
| R-HSA-9671793 | Diseases of hemostasis | 0.351141 | 0.455 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.351141 | 0.455 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.352908 | 0.452 |
| R-HSA-9707616 | Heme signaling | 0.359371 | 0.444 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.359371 | 0.444 |
| R-HSA-9609646 | HCMV Infection | 0.359710 | 0.444 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.362739 | 0.440 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.362739 | 0.440 |
| R-HSA-3322077 | Glycogen synthesis | 0.362739 | 0.440 |
| R-HSA-445144 | Signal transduction by L1 | 0.362739 | 0.440 |
| R-HSA-373753 | Nephrin family interactions | 0.362739 | 0.440 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.365811 | 0.437 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.365811 | 0.437 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.367226 | 0.435 |
| R-HSA-69306 | DNA Replication | 0.370678 | 0.431 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.371857 | 0.430 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.372226 | 0.429 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.372226 | 0.429 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.374131 | 0.427 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.374131 | 0.427 |
| R-HSA-167044 | Signalling to RAS | 0.374131 | 0.427 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.374131 | 0.427 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.374131 | 0.427 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.374131 | 0.427 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.374131 | 0.427 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.374131 | 0.427 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.374131 | 0.427 |
| R-HSA-210991 | Basigin interactions | 0.374131 | 0.427 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 0.374131 | 0.427 |
| R-HSA-8953854 | Metabolism of RNA | 0.374667 | 0.426 |
| R-HSA-202403 | TCR signaling | 0.376710 | 0.424 |
| R-HSA-73894 | DNA Repair | 0.377686 | 0.423 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.378615 | 0.422 |
| R-HSA-109582 | Hemostasis | 0.379214 | 0.421 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.384976 | 0.415 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.384976 | 0.415 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.385320 | 0.414 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.385320 | 0.414 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.391310 | 0.407 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.396309 | 0.402 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.396309 | 0.402 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.396309 | 0.402 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.396309 | 0.402 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.405651 | 0.392 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.407103 | 0.390 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.407103 | 0.390 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.407103 | 0.390 |
| R-HSA-3000170 | Syndecan interactions | 0.407103 | 0.390 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.407103 | 0.390 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.410130 | 0.387 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.410130 | 0.387 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.415215 | 0.382 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.415215 | 0.382 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.416340 | 0.381 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.417704 | 0.379 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.417704 | 0.379 |
| R-HSA-429947 | Deadenylation of mRNA | 0.417704 | 0.379 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.417704 | 0.379 |
| R-HSA-70326 | Glucose metabolism | 0.419978 | 0.377 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.422518 | 0.374 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.422518 | 0.374 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.424729 | 0.372 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.428116 | 0.368 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.428116 | 0.368 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.428116 | 0.368 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.428116 | 0.368 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.428116 | 0.368 |
| R-HSA-9839394 | TGFBR3 expression | 0.428116 | 0.368 |
| R-HSA-3214842 | HDMs demethylate histones | 0.428116 | 0.368 |
| R-HSA-3000157 | Laminin interactions | 0.428116 | 0.368 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.428662 | 0.368 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.428662 | 0.368 |
| R-HSA-68875 | Mitotic Prophase | 0.434190 | 0.362 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.434771 | 0.362 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.438343 | 0.358 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.438343 | 0.358 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.438343 | 0.358 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.438343 | 0.358 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.438343 | 0.358 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.438343 | 0.358 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.438343 | 0.358 |
| R-HSA-3371556 | Cellular response to heat stress | 0.438899 | 0.358 |
| R-HSA-380287 | Centrosome maturation | 0.440845 | 0.356 |
| R-HSA-8852135 | Protein ubiquitination | 0.440845 | 0.356 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.440845 | 0.356 |
| R-HSA-913531 | Interferon Signaling | 0.442803 | 0.354 |
| R-HSA-5689603 | UCH proteinases | 0.446884 | 0.350 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.446884 | 0.350 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.448272 | 0.348 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.448272 | 0.348 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.448272 | 0.348 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.448387 | 0.348 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.448387 | 0.348 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.448387 | 0.348 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.448387 | 0.348 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.458253 | 0.339 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.458253 | 0.339 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.458253 | 0.339 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.461267 | 0.336 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.462167 | 0.335 |
| R-HSA-69206 | G1/S Transition | 0.462212 | 0.335 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.467942 | 0.330 |
| R-HSA-180024 | DARPP-32 events | 0.467942 | 0.330 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.470665 | 0.327 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.470665 | 0.327 |
| R-HSA-114608 | Platelet degranulation | 0.471421 | 0.327 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.477438 | 0.321 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.477459 | 0.321 |
| R-HSA-2424491 | DAP12 signaling | 0.477459 | 0.321 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.477459 | 0.321 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.477459 | 0.321 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.477459 | 0.321 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.477459 | 0.321 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.482798 | 0.316 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.485099 | 0.314 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.486806 | 0.313 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.486806 | 0.313 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.486806 | 0.313 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.486806 | 0.313 |
| R-HSA-186763 | Downstream signal transduction | 0.486806 | 0.313 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.488095 | 0.311 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.493825 | 0.306 |
| R-HSA-69190 | DNA strand elongation | 0.495987 | 0.305 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.495987 | 0.305 |
| R-HSA-9909396 | Circadian clock | 0.498607 | 0.302 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.499515 | 0.301 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.501572 | 0.300 |
| R-HSA-157118 | Signaling by NOTCH | 0.503154 | 0.298 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.505004 | 0.297 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.505004 | 0.297 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.505004 | 0.297 |
| R-HSA-9930044 | Nuclear RNA decay | 0.505004 | 0.297 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.505004 | 0.297 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.505004 | 0.297 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.510770 | 0.292 |
| R-HSA-390522 | Striated Muscle Contraction | 0.513860 | 0.289 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.513860 | 0.289 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.513860 | 0.289 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.513860 | 0.289 |
| R-HSA-70268 | Pyruvate metabolism | 0.516336 | 0.287 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.516336 | 0.287 |
| R-HSA-983712 | Ion channel transport | 0.516385 | 0.287 |
| R-HSA-5617833 | Cilium Assembly | 0.520129 | 0.284 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.521859 | 0.282 |
| R-HSA-156902 | Peptide chain elongation | 0.521859 | 0.282 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.522558 | 0.282 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.522558 | 0.282 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.522558 | 0.282 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.531101 | 0.275 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.531101 | 0.275 |
| R-HSA-187687 | Signalling to ERKs | 0.531101 | 0.275 |
| R-HSA-381042 | PERK regulates gene expression | 0.531101 | 0.275 |
| R-HSA-4839726 | Chromatin organization | 0.533086 | 0.273 |
| R-HSA-6807070 | PTEN Regulation | 0.533724 | 0.273 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.533724 | 0.273 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.536537 | 0.270 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.538175 | 0.269 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.538175 | 0.269 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.539492 | 0.268 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.539492 | 0.268 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.539492 | 0.268 |
| R-HSA-111933 | Calmodulin induced events | 0.539492 | 0.268 |
| R-HSA-111997 | CaM pathway | 0.539492 | 0.268 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.539492 | 0.268 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.539492 | 0.268 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.539492 | 0.268 |
| R-HSA-421270 | Cell-cell junction organization | 0.539628 | 0.268 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.543528 | 0.265 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.543528 | 0.265 |
| R-HSA-4641258 | Degradation of DVL | 0.547733 | 0.261 |
| R-HSA-4641257 | Degradation of AXIN | 0.547733 | 0.261 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.547733 | 0.261 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.547733 | 0.261 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.547733 | 0.261 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.548837 | 0.261 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.548837 | 0.261 |
| R-HSA-391251 | Protein folding | 0.548837 | 0.261 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.550757 | 0.259 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.555828 | 0.255 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.555828 | 0.255 |
| R-HSA-1566948 | Elastic fibre formation | 0.555828 | 0.255 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.563777 | 0.249 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.563777 | 0.249 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.563777 | 0.249 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.563777 | 0.249 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.564506 | 0.248 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.567419 | 0.246 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.567496 | 0.246 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.569642 | 0.244 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.569642 | 0.244 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.571585 | 0.243 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.571585 | 0.243 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.571585 | 0.243 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.571585 | 0.243 |
| R-HSA-8982491 | Glycogen metabolism | 0.571585 | 0.243 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.579254 | 0.237 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.579254 | 0.237 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.579254 | 0.237 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.579254 | 0.237 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.579254 | 0.237 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.579254 | 0.237 |
| R-HSA-157579 | Telomere Maintenance | 0.579781 | 0.237 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.579781 | 0.237 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.586786 | 0.232 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.586786 | 0.232 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.586786 | 0.232 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.586786 | 0.232 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.586786 | 0.232 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.586786 | 0.232 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.586786 | 0.232 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.586786 | 0.232 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.589745 | 0.229 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.589745 | 0.229 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.592820 | 0.227 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.594183 | 0.226 |
| R-HSA-111996 | Ca-dependent events | 0.594183 | 0.226 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.599533 | 0.222 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.601449 | 0.221 |
| R-HSA-8854214 | TBC/RABGAPs | 0.601449 | 0.221 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.601449 | 0.221 |
| R-HSA-397014 | Muscle contraction | 0.602123 | 0.220 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.602123 | 0.220 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.604360 | 0.219 |
| R-HSA-2172127 | DAP12 interactions | 0.608585 | 0.216 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.608585 | 0.216 |
| R-HSA-190828 | Gap junction trafficking | 0.608585 | 0.216 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.608585 | 0.216 |
| R-HSA-69236 | G1 Phase | 0.608585 | 0.216 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.608585 | 0.216 |
| R-HSA-192823 | Viral mRNA Translation | 0.609144 | 0.215 |
| R-HSA-9610379 | HCMV Late Events | 0.611238 | 0.214 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.613884 | 0.212 |
| R-HSA-111885 | Opioid Signalling | 0.613884 | 0.212 |
| R-HSA-9711097 | Cellular response to starvation | 0.615072 | 0.211 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.615594 | 0.211 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.615594 | 0.211 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.615594 | 0.211 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.615594 | 0.211 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.622477 | 0.206 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.622477 | 0.206 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.622477 | 0.206 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.623232 | 0.205 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.627840 | 0.202 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.632404 | 0.199 |
| R-HSA-211000 | Gene Silencing by RNA | 0.632404 | 0.199 |
| R-HSA-5620924 | Intraflagellar transport | 0.635878 | 0.197 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.635878 | 0.197 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.636924 | 0.196 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.636924 | 0.196 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.636924 | 0.196 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.642399 | 0.192 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.642399 | 0.192 |
| R-HSA-109704 | PI3K Cascade | 0.648804 | 0.188 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.648804 | 0.188 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.654572 | 0.184 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.654572 | 0.184 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.654572 | 0.184 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.654572 | 0.184 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.655095 | 0.184 |
| R-HSA-912446 | Meiotic recombination | 0.655095 | 0.184 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.655095 | 0.184 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.655095 | 0.184 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.661273 | 0.180 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.661273 | 0.180 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.661273 | 0.180 |
| R-HSA-72306 | tRNA processing | 0.662572 | 0.179 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.667342 | 0.176 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.667342 | 0.176 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.667342 | 0.176 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.667342 | 0.176 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.669491 | 0.174 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.672912 | 0.172 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.672912 | 0.172 |
| R-HSA-418597 | G alpha (z) signalling events | 0.679155 | 0.168 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.679155 | 0.168 |
| R-HSA-195721 | Signaling by WNT | 0.679241 | 0.168 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.684904 | 0.164 |
| R-HSA-112399 | IRS-mediated signalling | 0.690550 | 0.161 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.696095 | 0.157 |
| R-HSA-73886 | Chromosome Maintenance | 0.699583 | 0.155 |
| R-HSA-9033241 | Peroxisomal protein import | 0.701542 | 0.154 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.706891 | 0.151 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.706891 | 0.151 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.712144 | 0.147 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.712144 | 0.147 |
| R-HSA-112043 | PLC beta mediated events | 0.712144 | 0.147 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.717304 | 0.144 |
| R-HSA-186797 | Signaling by PDGF | 0.717304 | 0.144 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.718384 | 0.144 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.718384 | 0.144 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.718384 | 0.144 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.733227 | 0.135 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.733988 | 0.134 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.740902 | 0.130 |
| R-HSA-112040 | G-protein mediated events | 0.741752 | 0.130 |
| R-HSA-5576891 | Cardiac conduction | 0.743039 | 0.129 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.744489 | 0.128 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.746383 | 0.127 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.746383 | 0.127 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.750931 | 0.124 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.755397 | 0.122 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.755397 | 0.122 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.755397 | 0.122 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.755397 | 0.122 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.755577 | 0.122 |
| R-HSA-1266738 | Developmental Biology | 0.756572 | 0.121 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.759784 | 0.119 |
| R-HSA-3000178 | ECM proteoglycans | 0.759784 | 0.119 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.759784 | 0.119 |
| R-HSA-8978934 | Metabolism of cofactors | 0.759784 | 0.119 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.759784 | 0.119 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.762761 | 0.118 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.763637 | 0.117 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.764093 | 0.117 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.765827 | 0.116 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.768324 | 0.114 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.768324 | 0.114 |
| R-HSA-4086398 | Ca2+ pathway | 0.768324 | 0.114 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.768324 | 0.114 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.768936 | 0.114 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.772480 | 0.112 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.772480 | 0.112 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.776561 | 0.110 |
| R-HSA-917937 | Iron uptake and transport | 0.776561 | 0.110 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.776561 | 0.110 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.780570 | 0.108 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.784507 | 0.105 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.784507 | 0.105 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.788373 | 0.103 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.788373 | 0.103 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.788373 | 0.103 |
| R-HSA-5619084 | ABC transporter disorders | 0.788373 | 0.103 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.795363 | 0.099 |
| R-HSA-977225 | Amyloid fiber formation | 0.799562 | 0.097 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.799562 | 0.097 |
| R-HSA-418990 | Adherens junctions interactions | 0.803049 | 0.095 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.806693 | 0.093 |
| R-HSA-8951664 | Neddylation | 0.809794 | 0.092 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.810162 | 0.091 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.810568 | 0.091 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.811422 | 0.091 |
| R-HSA-1500620 | Meiosis | 0.813570 | 0.090 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.816529 | 0.088 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.816916 | 0.088 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.816916 | 0.088 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.826601 | 0.083 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.829715 | 0.081 |
| R-HSA-202424 | Downstream TCR signaling | 0.832773 | 0.079 |
| R-HSA-73884 | Base Excision Repair | 0.832773 | 0.079 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.835776 | 0.078 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.840257 | 0.076 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.841621 | 0.075 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.841621 | 0.075 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.841621 | 0.075 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.842556 | 0.074 |
| R-HSA-5619102 | SLC transporter disorders | 0.846815 | 0.072 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.847260 | 0.072 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.852698 | 0.069 |
| R-HSA-168256 | Immune System | 0.854737 | 0.068 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.855179 | 0.068 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.855345 | 0.068 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.855345 | 0.068 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.855345 | 0.068 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.855345 | 0.068 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.855345 | 0.068 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.857205 | 0.067 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.860463 | 0.065 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.860496 | 0.065 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.860496 | 0.065 |
| R-HSA-3214847 | HATs acetylate histones | 0.863003 | 0.064 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.865050 | 0.063 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.865465 | 0.063 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.865465 | 0.063 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.866691 | 0.062 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.870257 | 0.060 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.872589 | 0.059 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.874879 | 0.058 |
| R-HSA-9833110 | RSV-host interactions | 0.877128 | 0.057 |
| R-HSA-1474244 | Extracellular matrix organization | 0.877993 | 0.057 |
| R-HSA-418346 | Platelet homeostasis | 0.881506 | 0.055 |
| R-HSA-416476 | G alpha (q) signalling events | 0.886838 | 0.052 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.887784 | 0.052 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.887899 | 0.052 |
| R-HSA-168249 | Innate Immune System | 0.894387 | 0.048 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.895641 | 0.048 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.897518 | 0.047 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.899361 | 0.046 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.902950 | 0.044 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.902950 | 0.044 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.906410 | 0.043 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.906410 | 0.043 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.909748 | 0.041 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.912967 | 0.040 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.912967 | 0.040 |
| R-HSA-1280218 | Adaptive Immune System | 0.916857 | 0.038 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.917583 | 0.037 |
| R-HSA-977606 | Regulation of Complement cascade | 0.919066 | 0.037 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.923240 | 0.035 |
| R-HSA-9824446 | Viral Infection Pathways | 0.926284 | 0.033 |
| R-HSA-1474165 | Reproduction | 0.928733 | 0.032 |
| R-HSA-9843745 | Adipogenesis | 0.930016 | 0.032 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.937248 | 0.028 |
| R-HSA-5368287 | Mitochondrial translation | 0.939489 | 0.027 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.939489 | 0.027 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.941650 | 0.026 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.941650 | 0.026 |
| R-HSA-9664407 | Parasite infection | 0.941650 | 0.026 |
| R-HSA-72312 | rRNA processing | 0.942129 | 0.026 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.942702 | 0.026 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.946723 | 0.024 |
| R-HSA-166658 | Complement cascade | 0.947683 | 0.023 |
| R-HSA-388396 | GPCR downstream signalling | 0.951099 | 0.022 |
| R-HSA-9758941 | Gastrulation | 0.951356 | 0.022 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.952233 | 0.021 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.953094 | 0.021 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.953940 | 0.020 |
| R-HSA-9609507 | Protein localization | 0.954771 | 0.020 |
| R-HSA-1989781 | PPARA activates gene expression | 0.956388 | 0.019 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.957948 | 0.019 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.958602 | 0.018 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.958706 | 0.018 |
| R-HSA-597592 | Post-translational protein modification | 0.958809 | 0.018 |
| R-HSA-72766 | Translation | 0.962410 | 0.017 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.969704 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.972988 | 0.012 |
| R-HSA-6798695 | Neutrophil degranulation | 0.973674 | 0.012 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.974289 | 0.011 |
| R-HSA-112316 | Neuronal System | 0.977167 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 0.978410 | 0.009 |
| R-HSA-9679506 | SARS-CoV Infections | 0.978768 | 0.009 |
| R-HSA-428157 | Sphingolipid metabolism | 0.981487 | 0.008 |
| R-HSA-6805567 | Keratinization | 0.983409 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.995236 | 0.002 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.995797 | 0.002 |
| R-HSA-9658195 | Leishmania infection | 0.995797 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 0.996390 | 0.002 |
| R-HSA-1643685 | Disease | 0.996665 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998358 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.998644 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.999087 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999328 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999720 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999943 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | -0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.888 | 0.237 | 2 | 0.852 |
CLK3 |
0.888 | 0.351 | 1 | 0.923 |
MOS |
0.875 | 0.215 | 1 | 0.902 |
NDR2 |
0.875 | 0.150 | -3 | 0.848 |
PIM3 |
0.875 | 0.167 | -3 | 0.850 |
CDC7 |
0.875 | 0.106 | 1 | 0.875 |
KIS |
0.873 | 0.253 | 1 | 0.804 |
MTOR |
0.873 | 0.105 | 1 | 0.859 |
SRPK1 |
0.872 | 0.230 | -3 | 0.778 |
CDKL1 |
0.872 | 0.212 | -3 | 0.816 |
GRK1 |
0.870 | 0.218 | -2 | 0.830 |
HIPK4 |
0.870 | 0.262 | 1 | 0.870 |
IKKB |
0.869 | 0.024 | -2 | 0.754 |
PRPK |
0.869 | -0.017 | -1 | 0.874 |
SKMLCK |
0.868 | 0.196 | -2 | 0.878 |
NLK |
0.868 | 0.171 | 1 | 0.918 |
CDKL5 |
0.868 | 0.225 | -3 | 0.814 |
ICK |
0.867 | 0.266 | -3 | 0.847 |
ATR |
0.866 | 0.096 | 1 | 0.876 |
ERK5 |
0.865 | 0.152 | 1 | 0.882 |
PRKD1 |
0.865 | 0.145 | -3 | 0.830 |
CAMK1B |
0.863 | 0.054 | -3 | 0.837 |
RSK2 |
0.863 | 0.139 | -3 | 0.781 |
RAF1 |
0.862 | -0.053 | 1 | 0.868 |
CHAK2 |
0.862 | 0.100 | -1 | 0.856 |
TBK1 |
0.861 | -0.036 | 1 | 0.764 |
PDHK4 |
0.861 | -0.178 | 1 | 0.895 |
CAMK2G |
0.861 | -0.020 | 2 | 0.803 |
PIM1 |
0.861 | 0.145 | -3 | 0.797 |
GRK5 |
0.861 | 0.004 | -3 | 0.837 |
DYRK2 |
0.861 | 0.257 | 1 | 0.797 |
BMPR2 |
0.861 | -0.086 | -2 | 0.888 |
IKKA |
0.860 | 0.047 | -2 | 0.756 |
NDR1 |
0.860 | 0.047 | -3 | 0.831 |
CDK1 |
0.860 | 0.252 | 1 | 0.754 |
CLK2 |
0.860 | 0.288 | -3 | 0.761 |
P90RSK |
0.859 | 0.116 | -3 | 0.792 |
DSTYK |
0.859 | -0.060 | 2 | 0.859 |
PRKD2 |
0.858 | 0.121 | -3 | 0.772 |
NEK6 |
0.858 | -0.016 | -2 | 0.865 |
GRK7 |
0.858 | 0.187 | 1 | 0.823 |
SRPK2 |
0.858 | 0.177 | -3 | 0.706 |
RIPK3 |
0.857 | 0.013 | 3 | 0.744 |
LATS2 |
0.857 | 0.055 | -5 | 0.704 |
IKKE |
0.857 | -0.077 | 1 | 0.755 |
PKN3 |
0.856 | 0.039 | -3 | 0.826 |
CAMLCK |
0.856 | 0.060 | -2 | 0.856 |
CDK18 |
0.856 | 0.248 | 1 | 0.728 |
NIK |
0.856 | -0.000 | -3 | 0.848 |
AURC |
0.856 | 0.117 | -2 | 0.671 |
GCN2 |
0.856 | -0.204 | 2 | 0.781 |
CDK8 |
0.856 | 0.184 | 1 | 0.780 |
MLK1 |
0.856 | -0.037 | 2 | 0.770 |
MAPKAPK2 |
0.856 | 0.120 | -3 | 0.749 |
CAMK2D |
0.855 | 0.048 | -3 | 0.828 |
GRK6 |
0.855 | 0.051 | 1 | 0.869 |
NUAK2 |
0.855 | 0.041 | -3 | 0.829 |
MARK4 |
0.855 | 0.038 | 4 | 0.843 |
DAPK2 |
0.854 | 0.063 | -3 | 0.849 |
AMPKA1 |
0.854 | 0.061 | -3 | 0.840 |
SRPK3 |
0.854 | 0.156 | -3 | 0.748 |
HIPK2 |
0.854 | 0.277 | 1 | 0.721 |
WNK1 |
0.854 | 0.004 | -2 | 0.894 |
JNK2 |
0.854 | 0.248 | 1 | 0.738 |
BMPR1B |
0.854 | 0.163 | 1 | 0.828 |
MST4 |
0.854 | 0.008 | 2 | 0.822 |
CDK19 |
0.854 | 0.202 | 1 | 0.743 |
TGFBR2 |
0.853 | -0.034 | -2 | 0.804 |
MAPKAPK3 |
0.853 | 0.054 | -3 | 0.782 |
PKCD |
0.853 | 0.064 | 2 | 0.749 |
ULK2 |
0.853 | -0.193 | 2 | 0.754 |
CDK7 |
0.852 | 0.184 | 1 | 0.790 |
PKACG |
0.852 | 0.058 | -2 | 0.753 |
CAMK2B |
0.852 | 0.101 | 2 | 0.784 |
CLK4 |
0.852 | 0.181 | -3 | 0.769 |
NEK7 |
0.852 | -0.146 | -3 | 0.817 |
LATS1 |
0.852 | 0.141 | -3 | 0.861 |
P38B |
0.852 | 0.271 | 1 | 0.750 |
JNK3 |
0.852 | 0.221 | 1 | 0.773 |
HUNK |
0.852 | -0.068 | 2 | 0.814 |
PDHK1 |
0.852 | -0.231 | 1 | 0.866 |
PKN2 |
0.852 | 0.021 | -3 | 0.821 |
RSK3 |
0.852 | 0.068 | -3 | 0.770 |
CAMK2A |
0.852 | 0.118 | 2 | 0.808 |
DLK |
0.851 | -0.017 | 1 | 0.869 |
GRK4 |
0.850 | -0.032 | -2 | 0.854 |
MLK2 |
0.850 | -0.001 | 2 | 0.792 |
RSK4 |
0.850 | 0.136 | -3 | 0.766 |
MASTL |
0.850 | -0.142 | -2 | 0.829 |
P38A |
0.849 | 0.242 | 1 | 0.816 |
CDK13 |
0.849 | 0.172 | 1 | 0.767 |
HIPK1 |
0.849 | 0.239 | 1 | 0.816 |
MLK3 |
0.849 | 0.028 | 2 | 0.697 |
CDK5 |
0.849 | 0.204 | 1 | 0.807 |
PKACB |
0.848 | 0.129 | -2 | 0.680 |
P70S6KB |
0.848 | 0.032 | -3 | 0.790 |
AMPKA2 |
0.848 | 0.054 | -3 | 0.812 |
PRKX |
0.848 | 0.160 | -3 | 0.703 |
MSK1 |
0.848 | 0.116 | -3 | 0.769 |
MSK2 |
0.848 | 0.062 | -3 | 0.770 |
ERK1 |
0.848 | 0.222 | 1 | 0.742 |
TSSK1 |
0.847 | 0.054 | -3 | 0.856 |
P38G |
0.847 | 0.223 | 1 | 0.670 |
TGFBR1 |
0.846 | 0.063 | -2 | 0.812 |
CLK1 |
0.846 | 0.169 | -3 | 0.736 |
ALK4 |
0.846 | 0.029 | -2 | 0.839 |
PRP4 |
0.846 | 0.242 | -3 | 0.824 |
CDK3 |
0.846 | 0.228 | 1 | 0.694 |
DYRK1A |
0.845 | 0.224 | 1 | 0.846 |
TSSK2 |
0.845 | 0.012 | -5 | 0.824 |
DYRK4 |
0.845 | 0.245 | 1 | 0.735 |
ATM |
0.845 | 0.005 | 1 | 0.812 |
QSK |
0.845 | 0.068 | 4 | 0.825 |
FAM20C |
0.845 | 0.015 | 2 | 0.566 |
RIPK1 |
0.844 | -0.111 | 1 | 0.852 |
BCKDK |
0.844 | -0.172 | -1 | 0.807 |
CDK17 |
0.844 | 0.198 | 1 | 0.676 |
PAK1 |
0.844 | 0.021 | -2 | 0.796 |
PKCB |
0.844 | 0.040 | 2 | 0.692 |
NEK9 |
0.844 | -0.162 | 2 | 0.802 |
NIM1 |
0.843 | -0.038 | 3 | 0.778 |
PASK |
0.843 | 0.195 | -3 | 0.868 |
MNK2 |
0.843 | 0.042 | -2 | 0.792 |
CDK12 |
0.843 | 0.176 | 1 | 0.742 |
PKCA |
0.843 | 0.050 | 2 | 0.685 |
MAK |
0.842 | 0.356 | -2 | 0.842 |
SMG1 |
0.842 | 0.024 | 1 | 0.825 |
ANKRD3 |
0.842 | -0.141 | 1 | 0.885 |
ULK1 |
0.842 | -0.233 | -3 | 0.774 |
CDK14 |
0.842 | 0.208 | 1 | 0.769 |
IRE1 |
0.841 | -0.054 | 1 | 0.828 |
ACVR2B |
0.841 | 0.056 | -2 | 0.801 |
PKR |
0.841 | -0.012 | 1 | 0.870 |
AKT2 |
0.841 | 0.116 | -3 | 0.703 |
PKCG |
0.840 | 0.009 | 2 | 0.692 |
P38D |
0.840 | 0.246 | 1 | 0.682 |
PKCZ |
0.840 | 0.021 | 2 | 0.738 |
GSK3A |
0.840 | 0.173 | 4 | 0.523 |
YSK4 |
0.840 | -0.074 | 1 | 0.808 |
MYLK4 |
0.840 | 0.053 | -2 | 0.773 |
VRK2 |
0.839 | -0.052 | 1 | 0.912 |
CAMK4 |
0.839 | -0.070 | -3 | 0.798 |
AURB |
0.839 | 0.049 | -2 | 0.668 |
TTBK2 |
0.839 | -0.168 | 2 | 0.667 |
ACVR2A |
0.839 | 0.032 | -2 | 0.791 |
ALK2 |
0.839 | 0.046 | -2 | 0.823 |
CK1E |
0.839 | 0.092 | -3 | 0.592 |
DNAPK |
0.839 | 0.063 | 1 | 0.745 |
PLK1 |
0.839 | -0.064 | -2 | 0.795 |
PRKD3 |
0.839 | 0.048 | -3 | 0.735 |
PKG2 |
0.839 | 0.064 | -2 | 0.681 |
TLK2 |
0.839 | -0.010 | 1 | 0.825 |
WNK3 |
0.838 | -0.275 | 1 | 0.849 |
PAK3 |
0.838 | -0.044 | -2 | 0.782 |
CDK2 |
0.838 | 0.106 | 1 | 0.823 |
MEK1 |
0.838 | -0.140 | 2 | 0.832 |
HIPK3 |
0.837 | 0.183 | 1 | 0.815 |
ERK2 |
0.837 | 0.141 | 1 | 0.794 |
MPSK1 |
0.837 | 0.194 | 1 | 0.830 |
DYRK1B |
0.837 | 0.190 | 1 | 0.770 |
MNK1 |
0.837 | 0.025 | -2 | 0.798 |
QIK |
0.837 | -0.071 | -3 | 0.814 |
MLK4 |
0.837 | -0.051 | 2 | 0.675 |
GRK2 |
0.836 | 0.005 | -2 | 0.756 |
MELK |
0.836 | -0.023 | -3 | 0.792 |
CDK16 |
0.836 | 0.204 | 1 | 0.695 |
BRSK1 |
0.836 | -0.007 | -3 | 0.783 |
SGK3 |
0.836 | 0.067 | -3 | 0.776 |
DYRK3 |
0.836 | 0.192 | 1 | 0.810 |
MARK3 |
0.835 | 0.032 | 4 | 0.782 |
CDK9 |
0.835 | 0.114 | 1 | 0.773 |
NUAK1 |
0.835 | -0.028 | -3 | 0.774 |
AURA |
0.835 | 0.047 | -2 | 0.647 |
CHAK1 |
0.835 | -0.099 | 2 | 0.750 |
SIK |
0.835 | 0.017 | -3 | 0.750 |
PHKG1 |
0.834 | -0.052 | -3 | 0.818 |
DCAMKL1 |
0.834 | 0.042 | -3 | 0.776 |
CDK10 |
0.834 | 0.189 | 1 | 0.756 |
PAK2 |
0.834 | -0.035 | -2 | 0.781 |
PAK6 |
0.834 | 0.017 | -2 | 0.705 |
CK1D |
0.834 | 0.097 | -3 | 0.550 |
MST3 |
0.833 | 0.056 | 2 | 0.809 |
DRAK1 |
0.833 | -0.002 | 1 | 0.822 |
GSK3B |
0.833 | 0.091 | 4 | 0.515 |
MEKK3 |
0.833 | -0.029 | 1 | 0.840 |
PIM2 |
0.832 | 0.061 | -3 | 0.751 |
CHK1 |
0.832 | -0.024 | -3 | 0.804 |
BRSK2 |
0.832 | -0.056 | -3 | 0.797 |
MARK2 |
0.832 | -0.004 | 4 | 0.748 |
PKCH |
0.832 | -0.044 | 2 | 0.675 |
NEK2 |
0.831 | -0.145 | 2 | 0.775 |
PKACA |
0.831 | 0.093 | -2 | 0.630 |
BMPR1A |
0.831 | 0.077 | 1 | 0.802 |
NEK5 |
0.830 | -0.023 | 1 | 0.867 |
TAO3 |
0.830 | 0.029 | 1 | 0.842 |
CAMK1G |
0.830 | 0.011 | -3 | 0.753 |
JNK1 |
0.829 | 0.178 | 1 | 0.727 |
MEKK2 |
0.829 | -0.037 | 2 | 0.774 |
PLK3 |
0.829 | -0.112 | 2 | 0.760 |
MAPKAPK5 |
0.829 | -0.051 | -3 | 0.739 |
MEK5 |
0.829 | -0.162 | 2 | 0.801 |
IRE2 |
0.829 | -0.106 | 2 | 0.696 |
PLK4 |
0.827 | -0.090 | 2 | 0.609 |
CK1A2 |
0.827 | 0.073 | -3 | 0.547 |
GAK |
0.827 | 0.096 | 1 | 0.887 |
GRK3 |
0.826 | 0.022 | -2 | 0.721 |
AKT1 |
0.825 | 0.080 | -3 | 0.722 |
MEKK1 |
0.825 | -0.154 | 1 | 0.838 |
ZAK |
0.825 | -0.133 | 1 | 0.809 |
MARK1 |
0.825 | -0.045 | 4 | 0.799 |
BRAF |
0.825 | -0.140 | -4 | 0.829 |
GCK |
0.824 | 0.089 | 1 | 0.835 |
PERK |
0.823 | -0.192 | -2 | 0.838 |
LKB1 |
0.823 | 0.024 | -3 | 0.826 |
SMMLCK |
0.823 | -0.003 | -3 | 0.806 |
CK1G1 |
0.823 | 0.012 | -3 | 0.580 |
MOK |
0.822 | 0.240 | 1 | 0.820 |
PDK1 |
0.822 | 0.022 | 1 | 0.844 |
DCAMKL2 |
0.822 | -0.033 | -3 | 0.782 |
WNK4 |
0.822 | -0.108 | -2 | 0.891 |
IRAK4 |
0.822 | -0.096 | 1 | 0.834 |
NEK11 |
0.822 | -0.090 | 1 | 0.833 |
PINK1 |
0.821 | -0.157 | 1 | 0.889 |
PKCT |
0.821 | -0.032 | 2 | 0.686 |
ERK7 |
0.820 | 0.028 | 2 | 0.489 |
CK2A2 |
0.819 | 0.075 | 1 | 0.729 |
HRI |
0.819 | -0.252 | -2 | 0.850 |
SNRK |
0.819 | -0.216 | 2 | 0.647 |
DAPK3 |
0.819 | 0.054 | -3 | 0.796 |
CAMK1D |
0.819 | 0.029 | -3 | 0.691 |
SSTK |
0.819 | -0.033 | 4 | 0.806 |
EEF2K |
0.818 | 0.021 | 3 | 0.848 |
CDK6 |
0.818 | 0.146 | 1 | 0.748 |
NEK8 |
0.818 | -0.139 | 2 | 0.775 |
PAK5 |
0.818 | -0.004 | -2 | 0.658 |
TLK1 |
0.818 | -0.177 | -2 | 0.838 |
PKCE |
0.817 | 0.030 | 2 | 0.676 |
P70S6K |
0.817 | -0.015 | -3 | 0.715 |
AKT3 |
0.816 | 0.102 | -3 | 0.661 |
CAMKK1 |
0.816 | -0.168 | -2 | 0.753 |
PDHK3_TYR |
0.816 | 0.351 | 4 | 0.905 |
HPK1 |
0.816 | 0.029 | 1 | 0.819 |
CAMKK2 |
0.816 | -0.108 | -2 | 0.756 |
TAO2 |
0.816 | -0.096 | 2 | 0.812 |
TNIK |
0.816 | 0.024 | 3 | 0.870 |
DAPK1 |
0.815 | 0.061 | -3 | 0.786 |
SGK1 |
0.815 | 0.097 | -3 | 0.645 |
TAK1 |
0.815 | -0.039 | 1 | 0.852 |
PKCI |
0.815 | -0.048 | 2 | 0.698 |
PAK4 |
0.815 | 0.008 | -2 | 0.668 |
CDK4 |
0.814 | 0.146 | 1 | 0.728 |
MST2 |
0.814 | -0.090 | 1 | 0.837 |
BUB1 |
0.813 | 0.130 | -5 | 0.776 |
HGK |
0.813 | -0.036 | 3 | 0.866 |
MAP3K15 |
0.813 | -0.050 | 1 | 0.802 |
CK2A1 |
0.813 | 0.083 | 1 | 0.709 |
MINK |
0.813 | -0.037 | 1 | 0.820 |
LRRK2 |
0.812 | -0.097 | 2 | 0.809 |
ROCK2 |
0.812 | 0.076 | -3 | 0.793 |
PDHK4_TYR |
0.811 | 0.275 | 2 | 0.873 |
KHS2 |
0.811 | 0.068 | 1 | 0.822 |
VRK1 |
0.811 | -0.042 | 2 | 0.816 |
KHS1 |
0.810 | 0.032 | 1 | 0.807 |
NEK4 |
0.810 | -0.142 | 1 | 0.821 |
MEKK6 |
0.810 | -0.107 | 1 | 0.832 |
TTBK1 |
0.810 | -0.211 | 2 | 0.591 |
NEK1 |
0.810 | -0.064 | 1 | 0.837 |
CHK2 |
0.809 | 0.040 | -3 | 0.645 |
PHKG2 |
0.808 | -0.121 | -3 | 0.762 |
PLK2 |
0.807 | -0.069 | -3 | 0.706 |
MRCKA |
0.807 | 0.024 | -3 | 0.751 |
MRCKB |
0.807 | 0.039 | -3 | 0.735 |
SLK |
0.807 | -0.075 | -2 | 0.731 |
LOK |
0.806 | -0.091 | -2 | 0.767 |
MAP2K6_TYR |
0.806 | 0.151 | -1 | 0.886 |
PBK |
0.805 | 0.018 | 1 | 0.803 |
MAP2K4_TYR |
0.805 | 0.123 | -1 | 0.885 |
CAMK1A |
0.805 | 0.034 | -3 | 0.657 |
PKN1 |
0.805 | -0.014 | -3 | 0.726 |
SBK |
0.805 | 0.081 | -3 | 0.592 |
IRAK1 |
0.804 | -0.316 | -1 | 0.777 |
MST1 |
0.804 | -0.129 | 1 | 0.819 |
TESK1_TYR |
0.803 | 0.039 | 3 | 0.884 |
DMPK1 |
0.803 | 0.081 | -3 | 0.748 |
PDHK1_TYR |
0.802 | 0.117 | -1 | 0.882 |
BMPR2_TYR |
0.802 | 0.103 | -1 | 0.883 |
STK33 |
0.802 | -0.152 | 2 | 0.599 |
OSR1 |
0.801 | -0.021 | 2 | 0.782 |
MAP2K7_TYR |
0.800 | -0.037 | 2 | 0.841 |
YSK1 |
0.800 | -0.112 | 2 | 0.770 |
HASPIN |
0.799 | 0.024 | -1 | 0.719 |
CK1A |
0.798 | 0.063 | -3 | 0.464 |
PKMYT1_TYR |
0.798 | -0.020 | 3 | 0.846 |
LIMK2_TYR |
0.798 | 0.061 | -3 | 0.861 |
CRIK |
0.797 | 0.066 | -3 | 0.731 |
TTK |
0.796 | -0.031 | -2 | 0.827 |
MEK2 |
0.794 | -0.295 | 2 | 0.792 |
YANK3 |
0.793 | -0.048 | 2 | 0.392 |
ROCK1 |
0.793 | 0.024 | -3 | 0.751 |
PKG1 |
0.793 | -0.004 | -2 | 0.584 |
PINK1_TYR |
0.792 | -0.177 | 1 | 0.891 |
TXK |
0.792 | 0.154 | 1 | 0.858 |
RIPK2 |
0.791 | -0.308 | 1 | 0.770 |
MYO3B |
0.790 | -0.046 | 2 | 0.779 |
EPHB4 |
0.790 | 0.035 | -1 | 0.833 |
ALPHAK3 |
0.790 | -0.042 | -1 | 0.778 |
BIKE |
0.789 | 0.009 | 1 | 0.760 |
NEK3 |
0.789 | -0.195 | 1 | 0.797 |
EPHA6 |
0.788 | -0.003 | -1 | 0.856 |
RET |
0.788 | -0.109 | 1 | 0.843 |
ASK1 |
0.788 | -0.140 | 1 | 0.790 |
FGR |
0.785 | -0.030 | 1 | 0.884 |
LIMK1_TYR |
0.785 | -0.194 | 2 | 0.820 |
ABL2 |
0.785 | 0.007 | -1 | 0.809 |
TYRO3 |
0.785 | -0.101 | 3 | 0.782 |
MST1R |
0.784 | -0.130 | 3 | 0.793 |
TNK2 |
0.784 | 0.017 | 3 | 0.738 |
CSF1R |
0.784 | -0.063 | 3 | 0.773 |
TAO1 |
0.784 | -0.118 | 1 | 0.764 |
YES1 |
0.784 | -0.026 | -1 | 0.850 |
MYO3A |
0.783 | -0.112 | 1 | 0.811 |
LCK |
0.783 | 0.066 | -1 | 0.842 |
ROS1 |
0.783 | -0.109 | 3 | 0.751 |
TYK2 |
0.782 | -0.208 | 1 | 0.835 |
JAK2 |
0.782 | -0.135 | 1 | 0.833 |
BLK |
0.781 | 0.084 | -1 | 0.838 |
EPHA4 |
0.781 | -0.022 | 2 | 0.772 |
ABL1 |
0.780 | -0.029 | -1 | 0.804 |
HCK |
0.780 | -0.026 | -1 | 0.841 |
ITK |
0.780 | 0.004 | -1 | 0.820 |
FER |
0.780 | -0.113 | 1 | 0.891 |
SRMS |
0.780 | -0.027 | 1 | 0.871 |
JAK3 |
0.780 | -0.106 | 1 | 0.832 |
DDR1 |
0.779 | -0.190 | 4 | 0.805 |
EPHB1 |
0.778 | -0.038 | 1 | 0.865 |
INSRR |
0.778 | -0.103 | 3 | 0.728 |
NEK10_TYR |
0.777 | -0.080 | 1 | 0.744 |
EPHB3 |
0.776 | -0.044 | -1 | 0.819 |
KIT |
0.776 | -0.096 | 3 | 0.775 |
KDR |
0.776 | -0.082 | 3 | 0.750 |
STLK3 |
0.776 | -0.192 | 1 | 0.779 |
FYN |
0.775 | 0.061 | -1 | 0.824 |
BMX |
0.775 | 0.008 | -1 | 0.748 |
AAK1 |
0.775 | 0.059 | 1 | 0.658 |
MERTK |
0.775 | -0.042 | 3 | 0.759 |
TNK1 |
0.775 | -0.073 | 3 | 0.765 |
FGFR2 |
0.774 | -0.155 | 3 | 0.784 |
EPHB2 |
0.774 | -0.045 | -1 | 0.805 |
MET |
0.774 | -0.057 | 3 | 0.766 |
JAK1 |
0.772 | -0.074 | 1 | 0.775 |
CK1G3 |
0.772 | 0.031 | -3 | 0.421 |
FLT1 |
0.772 | -0.060 | -1 | 0.815 |
TNNI3K_TYR |
0.771 | -0.073 | 1 | 0.831 |
TEC |
0.771 | -0.063 | -1 | 0.758 |
AXL |
0.770 | -0.126 | 3 | 0.753 |
WEE1_TYR |
0.769 | -0.101 | -1 | 0.772 |
PDGFRB |
0.768 | -0.245 | 3 | 0.790 |
EPHA7 |
0.768 | -0.055 | 2 | 0.762 |
BTK |
0.768 | -0.168 | -1 | 0.792 |
FLT3 |
0.768 | -0.211 | 3 | 0.783 |
TEK |
0.768 | -0.181 | 3 | 0.712 |
FGFR1 |
0.766 | -0.217 | 3 | 0.746 |
EPHA3 |
0.766 | -0.127 | 2 | 0.738 |
FGFR3 |
0.765 | -0.144 | 3 | 0.755 |
PTK2 |
0.765 | 0.058 | -1 | 0.798 |
LYN |
0.764 | -0.070 | 3 | 0.698 |
DDR2 |
0.763 | -0.045 | 3 | 0.716 |
FRK |
0.763 | -0.099 | -1 | 0.837 |
PTK6 |
0.763 | -0.227 | -1 | 0.753 |
ERBB2 |
0.762 | -0.180 | 1 | 0.795 |
EPHA1 |
0.762 | -0.126 | 3 | 0.744 |
SRC |
0.762 | -0.045 | -1 | 0.815 |
SYK |
0.762 | 0.050 | -1 | 0.773 |
NTRK1 |
0.762 | -0.235 | -1 | 0.811 |
PTK2B |
0.761 | -0.061 | -1 | 0.784 |
EPHA5 |
0.761 | -0.074 | 2 | 0.755 |
PDGFRA |
0.761 | -0.287 | 3 | 0.786 |
ALK |
0.761 | -0.202 | 3 | 0.694 |
LTK |
0.760 | -0.192 | 3 | 0.722 |
YANK2 |
0.760 | -0.075 | 2 | 0.405 |
NTRK3 |
0.759 | -0.150 | -1 | 0.767 |
EPHA8 |
0.759 | -0.078 | -1 | 0.806 |
MATK |
0.758 | -0.138 | -1 | 0.724 |
INSR |
0.757 | -0.209 | 3 | 0.701 |
EGFR |
0.757 | -0.102 | 1 | 0.706 |
FLT4 |
0.755 | -0.245 | 3 | 0.741 |
CK1G2 |
0.755 | 0.029 | -3 | 0.504 |
NTRK2 |
0.755 | -0.281 | 3 | 0.732 |
FGFR4 |
0.754 | -0.115 | -1 | 0.756 |
CSK |
0.754 | -0.163 | 2 | 0.762 |
EPHA2 |
0.751 | -0.065 | -1 | 0.771 |
ZAP70 |
0.748 | 0.039 | -1 | 0.715 |
ERBB4 |
0.746 | -0.060 | 1 | 0.718 |
IGF1R |
0.742 | -0.188 | 3 | 0.638 |
MUSK |
0.739 | -0.205 | 1 | 0.705 |
FES |
0.734 | -0.153 | -1 | 0.722 |