Motif 241 (n=182)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A4S6 | ARHGAP10 | S591 | ochoa | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}. |
| A7MCY6 | TBKBP1 | S400 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| A8MUU9 | None | S321 | ochoa | Putative uncharacterized protein ENSP00000383309 | None |
| E9PAV3 | NACA | S917 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S935 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1489 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00192 | ARVCF | S198 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00512 | BCL9 | S278 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14526 | FCHO1 | S529 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14686 | KMT2D | S1151 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S2423 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S4325 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O43379 | WDR62 | S1325 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O60245 | PCDH7 | S1011 | ochoa | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
| O60496 | DOK2 | S269 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| O75381 | PEX14 | S247 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75410 | TACC1 | S276 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75581 | LRP6 | S1490 | ochoa|psp | Low-density lipoprotein receptor-related protein 6 (LRP-6) | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250|UniProtKB:O88572, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:28341812}. |
| O75864 | PPP1R37 | S601 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O75962 | TRIO | S1763 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94868 | FCHSD2 | S665 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94885 | SASH1 | S1028 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95297 | MPZL1 | S219 | ochoa | Myelin protein zero-like protein 1 (Protein zero-related) | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| O95365 | ZBTB7A | S526 | ochoa | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}. |
| O96013 | PAK4 | S267 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P04626 | ERBB2 | S1151 | psp | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04626 | ERBB2 | S1235 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P12980 | LYL1 | S36 | ochoa|psp | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
| P16333 | NCK1 | S262 | ochoa | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| P18858 | LIG1 | S91 | ochoa|psp | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P26651 | ZFP36 | S228 | psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P27816 | MAP4 | S179 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28562 | DUSP1 | S323 | psp | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}. |
| P29372 | MPG | S49 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P29590 | PML | S527 | ochoa|psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P40222 | TXLNA | Y524 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P46108 | CRK | S83 | ochoa | Adapter molecule crk (Proto-oncogene c-Crk) (p38) | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}. |
| P46379 | BAG6 | S973 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P48634 | PRRC2A | S808 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S1691 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49418 | AMPH | S272 | ochoa|psp | Amphiphysin | May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. |
| P49418 | AMPH | S285 | ochoa|psp | Amphiphysin | May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. |
| P52824 | DGKQ | S26 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P54725 | RAD23A | S123 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P56945 | BCAR1 | S139 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P78559 | MAP1A | S2074 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01167 | FOXK2 | S195 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q03164 | KMT2A | S2151 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05193 | DNM1 | S822 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
| Q07912 | TNK2 | S757 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08174 | PCDH1 | S984 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q10713 | PMPCA | S35 | ochoa | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:25808372}. |
| Q12815 | TROAP | S324 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12968 | NFATC3 | S117 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13233 | MAP3K1 | S275 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13470 | TNK1 | S519 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q14160 | SCRIB | S835 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14676 | MDC1 | S1711 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14686 | NCOA6 | S1892 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14814 | MEF2D | S201 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14938 | NFIX | S250 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15648 | MED1 | S1042 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S1192 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15942 | ZYX | S290 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16204 | CCDC6 | S395 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16799 | RTN1 | S48 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q17R89 | ARHGAP44 | S640 | ochoa | Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}. |
| Q2M2I3 | FAM83E | S351 | ochoa | Protein FAM83E | May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}. |
| Q2M3V2 | SOWAHA | S193 | ochoa | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | None |
| Q3KQU3 | MAP7D1 | S89 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3MIN7 | RGL3 | S555 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q53ET0 | CRTC2 | S433 | ochoa|psp | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5SYE7 | NHSL1 | S851 | ochoa | NHS-like protein 1 | None |
| Q5T0Z8 | C6orf132 | S969 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1M5 | FKBP15 | S979 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5VV41 | ARHGEF16 | S41 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VV67 | PPRC1 | S842 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q63HR2 | TNS2 | S820 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q63HR2 | TNS2 | S991 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q63HR2 | TNS2 | S1096 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66K74 | MAP1S | S582 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6DD87 | ZNF787 | S46 | ochoa | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q6F5E8 | CARMIL2 | S1319 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6F5E8 | CARMIL2 | S1395 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6F5E8 | CARMIL2 | S1416 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ23 | PLEKHA7 | S871 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ23 | PLEKHA7 | S907 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6JBY9 | RCSD1 | S83 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6N043 | ZNF280D | S104 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P2E9 | EDC4 | S33 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P3S6 | FBXO42 | S587 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PGQ7 | BORA | S252 | ochoa|psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6PJF5 | RHBDF2 | S328 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6UWD8 | C16orf54 | S184 | ochoa | Transmembrane protein C16orf54 | None |
| Q6WCQ1 | MPRIP | S365 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZMT1 | STAC2 | S78 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
| Q6ZRV2 | FAM83H | S936 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZW31 | SYDE1 | S244 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q6ZW31 | SYDE1 | S645 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q7Z3K3 | POGZ | S434 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z401 | DENND4A | S1240 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z6I6 | ARHGAP30 | S480 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6J9 | TSEN54 | S249 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q7Z7L8 | C11orf96 | S299 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86VM9 | ZC3H18 | S852 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IV53 | DENND1C | S715 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8IX01 | SUGP2 | S757 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IX07 | ZFPM1 | S494 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S768 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY92 | SLX4 | S1329 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYB3 | SRRM1 | S389 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S616 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S628 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S738 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S775 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZD2 | KMT2E | S1359 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZW8 | TNS4 | S386 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N1G0 | ZNF687 | S140 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3F8 | MICALL1 | S295 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S486 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3V7 | SYNPO | S536 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4C8 | MINK1 | S555 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4C8 | MINK1 | S927 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NBF1 | GLIS1 | S464 | ochoa | Zinc finger protein GLIS1 (GLI-similar 1) | Acts both as a repressor and an activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity). {ECO:0000250|UniProtKB:Q8K1M4, ECO:0000269|PubMed:21654807}. |
| Q8ND24 | RNF214 | S501 | ochoa | RING finger protein 214 | None |
| Q8NE35 | CPEB3 | S195 | ochoa | Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3) | Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}. |
| Q8NFH5 | NUP35 | S25 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8NFH5 | NUP35 | S138 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8TCT7 | SPPL2B | S532 | ochoa | Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}. |
| Q8TDN4 | CABLES1 | S168 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TF74 | WIPF2 | S235 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WUM0 | NUP133 | S27 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WX93 | PALLD | S808 | psp | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WYP5 | AHCTF1 | S1142 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92625 | ANKS1A | S589 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92835 | INPP5D | S1039 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q969H4 | CNKSR1 | S314 | ochoa | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | May function as an adapter protein or regulator of Ras signaling pathways. |
| Q96A35 | MRPL24 | S24 | ochoa | Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24) | None |
| Q96AV8 | E2F7 | S840 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96GY3 | LIN37 | S182 | ochoa|psp | Protein lin-37 homolog (Antolefinin) | None |
| Q96HR8 | NAF1 | S50 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96JM3 | CHAMP1 | S164 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S173 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S184 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S264 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S275 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S286 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S297 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S308 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S319 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S344 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S355 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S427 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S436 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S542 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96N64 | PWWP2A | S119 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96PK6 | RBM14 | S215 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PN7 | TRERF1 | S715 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96RK0 | CIC | S301 | ochoa|psp | Protein capicua homolog | Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}. |
| Q96RY5 | CRAMP1 | S70 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96T58 | SPEN | S2481 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99590 | SCAF11 | S816 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99700 | ATXN2 | S937 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BU19 | ZNF692 | S251 | ochoa | Zinc finger protein 692 (AICAR responsive element binding protein) | May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}. |
| Q9C0K0 | BCL11B | S678 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H792 | PEAK1 | S854 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7D0 | DOCK5 | S1803 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H7P9 | PLEKHG2 | S469 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H7P9 | PLEKHG2 | S1163 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9NQU5 | PAK6 | S351 | ochoa | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NR12 | PDLIM7 | S217 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9P206 | NHSL3 | S562 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9ULC8 | ZDHHC8 | S682 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULC8 | ZDHHC8 | S725 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULH7 | MRTFB | S847 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UMN6 | KMT2B | S560 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMN6 | KMT2B | S2348 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPN7 | PPP6R1 | S726 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Q9UQ35 | SRRM2 | S2449 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB3 | CTNND2 | S276 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y3X0 | CCDC9 | S390 | ochoa | Coiled-coil domain-containing protein 9 | Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}. |
| Q9Y5W3 | KLF2 | S177 | ochoa|psp | Krueppel-like factor 2 (Lung krueppel-like factor) | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). {ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:28167758}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428540 | Activation of RAC1 | 0.000019 | 4.733 |
| R-HSA-186763 | Downstream signal transduction | 0.000577 | 3.239 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000922 | 3.035 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.001286 | 2.891 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.002200 | 2.658 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.004314 | 2.365 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.004194 | 2.377 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.004708 | 2.327 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005659 | 2.247 |
| R-HSA-186797 | Signaling by PDGF | 0.005731 | 2.242 |
| R-HSA-9707616 | Heme signaling | 0.005731 | 2.242 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.007604 | 2.119 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.009443 | 2.025 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.010277 | 1.988 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.010888 | 1.963 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.011549 | 1.937 |
| R-HSA-162582 | Signal Transduction | 0.010972 | 1.960 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.012961 | 1.887 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.012961 | 1.887 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.016023 | 1.795 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.017639 | 1.754 |
| R-HSA-9909396 | Circadian clock | 0.017526 | 1.756 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.019321 | 1.714 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.019921 | 1.701 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.021067 | 1.676 |
| R-HSA-373753 | Nephrin family interactions | 0.026679 | 1.574 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.025750 | 1.589 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.039447 | 1.404 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.039447 | 1.404 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.039447 | 1.404 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.039447 | 1.404 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.039447 | 1.404 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.039447 | 1.404 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.039447 | 1.404 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.039447 | 1.404 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.039447 | 1.404 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.039447 | 1.404 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.039447 | 1.404 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.049064 | 1.309 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.049064 | 1.309 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.058586 | 1.232 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.058586 | 1.232 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.032821 | 1.484 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.051526 | 1.288 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.054079 | 1.267 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.054079 | 1.267 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.059317 | 1.227 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.059317 | 1.227 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.049146 | 1.309 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.030780 | 1.512 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.039447 | 1.404 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.049064 | 1.309 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.049017 | 1.310 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.034310 | 1.465 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.059964 | 1.222 |
| R-HSA-6806834 | Signaling by MET | 0.059964 | 1.222 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.029594 | 1.529 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.042192 | 1.375 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.056767 | 1.246 |
| R-HSA-194138 | Signaling by VEGF | 0.053889 | 1.269 |
| R-HSA-525793 | Myogenesis | 0.041774 | 1.379 |
| R-HSA-354192 | Integrin signaling | 0.059317 | 1.227 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.035547 | 1.449 |
| R-HSA-8848021 | Signaling by PTK6 | 0.035547 | 1.449 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.051526 | 1.288 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.057355 | 1.241 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.056497 | 1.248 |
| R-HSA-73887 | Death Receptor Signaling | 0.030780 | 1.512 |
| R-HSA-422475 | Axon guidance | 0.061034 | 1.214 |
| R-HSA-5340588 | Signaling by RNF43 mutants | 0.077347 | 1.112 |
| R-HSA-8875656 | MET receptor recycling | 0.104793 | 0.980 |
| R-HSA-170984 | ARMS-mediated activation | 0.113760 | 0.944 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.122638 | 0.911 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.140130 | 0.853 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.148745 | 0.828 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.165719 | 0.781 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.174080 | 0.759 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.174080 | 0.759 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.061999 | 1.208 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.067484 | 1.171 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.190552 | 0.720 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.198665 | 0.702 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.078907 | 1.103 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.206698 | 0.685 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.081852 | 1.087 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.222523 | 0.653 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.222523 | 0.653 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.238035 | 0.623 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.238035 | 0.623 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.063243 | 1.199 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.260727 | 0.584 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.297065 | 0.527 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.304117 | 0.517 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.167632 | 0.776 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.244202 | 0.612 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.244202 | 0.612 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.275481 | 0.560 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.167914 | 0.775 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.167914 | 0.775 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.167914 | 0.775 |
| R-HSA-190873 | Gap junction degradation | 0.113760 | 0.944 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.190552 | 0.720 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.282748 | 0.549 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.113760 | 0.944 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.090883 | 1.042 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.304117 | 0.517 |
| R-HSA-3928664 | Ephrin signaling | 0.206698 | 0.685 |
| R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 0.140130 | 0.853 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.236796 | 0.626 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.304117 | 0.517 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.307222 | 0.513 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.240498 | 0.619 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.221244 | 0.655 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.292430 | 0.534 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.068014 | 1.167 |
| R-HSA-196025 | Formation of annular gap junctions | 0.104793 | 0.980 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.182357 | 0.739 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.073123 | 1.136 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.198665 | 0.702 |
| R-HSA-8875878 | MET promotes cell motility | 0.075997 | 1.119 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.206698 | 0.685 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.206698 | 0.685 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.100190 | 0.999 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.238035 | 0.623 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.260727 | 0.584 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.192765 | 0.715 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.222523 | 0.653 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.222523 | 0.653 |
| R-HSA-9620244 | Long-term potentiation | 0.268141 | 0.572 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.121436 | 0.916 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.061999 | 1.208 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.206698 | 0.685 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.264151 | 0.578 |
| R-HSA-9609507 | Protein localization | 0.247746 | 0.606 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.165719 | 0.781 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.165719 | 0.781 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.190552 | 0.720 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.222523 | 0.653 |
| R-HSA-191859 | snRNP Assembly | 0.146597 | 0.834 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.146597 | 0.834 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.153548 | 0.814 |
| R-HSA-169893 | Prolonged ERK activation events | 0.182357 | 0.739 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.275481 | 0.560 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.140130 | 0.853 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.174080 | 0.759 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.213411 | 0.671 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.064721 | 1.189 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.214650 | 0.668 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.210813 | 0.676 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.210813 | 0.676 |
| R-HSA-9664407 | Parasite infection | 0.210813 | 0.676 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.095736 | 1.019 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.148745 | 0.828 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.081852 | 1.087 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.081852 | 1.087 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.084830 | 1.071 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.238035 | 0.623 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.147602 | 0.831 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.268141 | 0.572 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.131428 | 0.881 |
| R-HSA-8949664 | Processing of SMDT1 | 0.157275 | 0.803 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.174080 | 0.759 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.075997 | 1.119 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.103350 | 0.986 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.192765 | 0.715 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.244202 | 0.612 |
| R-HSA-73894 | DNA Repair | 0.185728 | 0.731 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.084587 | 1.073 |
| R-HSA-449836 | Other interleukin signaling | 0.214650 | 0.668 |
| R-HSA-373752 | Netrin-1 signaling | 0.097059 | 1.013 |
| R-HSA-73884 | Base Excision Repair | 0.078992 | 1.102 |
| R-HSA-5689877 | Josephin domain DUBs | 0.122638 | 0.911 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.190552 | 0.720 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.078907 | 1.103 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.253239 | 0.596 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.307429 | 0.512 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.129534 | 0.888 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.139716 | 0.855 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.268141 | 0.572 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.268141 | 0.572 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.201792 | 0.695 |
| R-HSA-210990 | PECAM1 interactions | 0.131428 | 0.881 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.174080 | 0.759 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.139716 | 0.855 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.282748 | 0.549 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.130314 | 0.885 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.214209 | 0.669 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.103933 | 0.983 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.182357 | 0.739 |
| R-HSA-195721 | Signaling by WNT | 0.217801 | 0.662 |
| R-HSA-8963896 | HDL assembly | 0.165719 | 0.781 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.198665 | 0.702 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.100190 | 0.999 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.157047 | 0.804 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.109750 | 0.960 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.166621 | 0.778 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.192765 | 0.715 |
| R-HSA-9842663 | Signaling by LTK | 0.148745 | 0.828 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.198665 | 0.702 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.238035 | 0.623 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.185530 | 0.732 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.258464 | 0.588 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.230318 | 0.638 |
| R-HSA-70171 | Glycolysis | 0.307222 | 0.513 |
| R-HSA-9675108 | Nervous system development | 0.084582 | 1.073 |
| R-HSA-8853659 | RET signaling | 0.070284 | 1.153 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.245675 | 0.610 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.192765 | 0.715 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.186183 | 0.730 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.090883 | 1.042 |
| R-HSA-210993 | Tie2 Signaling | 0.206698 | 0.685 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.160561 | 0.794 |
| R-HSA-166520 | Signaling by NTRKs | 0.087744 | 1.057 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.203685 | 0.691 |
| R-HSA-5358508 | Mismatch Repair | 0.206698 | 0.685 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.218347 | 0.661 |
| R-HSA-4839726 | Chromatin organization | 0.286722 | 0.543 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.064721 | 1.189 |
| R-HSA-69242 | S Phase | 0.234426 | 0.630 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.260727 | 0.584 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.275481 | 0.560 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.176079 | 0.754 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.097059 | 1.013 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.233098 | 0.632 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.250424 | 0.601 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.238035 | 0.623 |
| R-HSA-72306 | tRNA processing | 0.296493 | 0.528 |
| R-HSA-109582 | Hemostasis | 0.292701 | 0.534 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.230318 | 0.638 |
| R-HSA-162587 | HIV Life Cycle | 0.258485 | 0.588 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.310166 | 0.508 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.314598 | 0.502 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.314598 | 0.502 |
| R-HSA-1538133 | G0 and Early G1 | 0.318010 | 0.498 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.318010 | 0.498 |
| R-HSA-69190 | DNA strand elongation | 0.318010 | 0.498 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.318010 | 0.498 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.324853 | 0.488 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.324853 | 0.488 |
| R-HSA-9930044 | Nuclear RNA decay | 0.324853 | 0.488 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.324853 | 0.488 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.324853 | 0.488 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.324853 | 0.488 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.325628 | 0.487 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.325628 | 0.487 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.329295 | 0.482 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.331628 | 0.479 |
| R-HSA-390522 | Striated Muscle Contraction | 0.331628 | 0.479 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.331628 | 0.479 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.331628 | 0.479 |
| R-HSA-211000 | Gene Silencing by RNA | 0.336612 | 0.473 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.338335 | 0.471 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.338335 | 0.471 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.343907 | 0.464 |
| R-HSA-169911 | Regulation of Apoptosis | 0.344975 | 0.462 |
| R-HSA-187687 | Signalling to ERKs | 0.344975 | 0.462 |
| R-HSA-202403 | TCR signaling | 0.347544 | 0.459 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.351549 | 0.454 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.351549 | 0.454 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.351549 | 0.454 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.351549 | 0.454 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.354573 | 0.450 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.358057 | 0.446 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.358057 | 0.446 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.358057 | 0.446 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.359124 | 0.445 |
| R-HSA-9658195 | Leishmania infection | 0.359124 | 0.445 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.362027 | 0.441 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.364305 | 0.439 |
| R-HSA-73927 | Depurination | 0.364501 | 0.438 |
| R-HSA-9609690 | HCMV Early Events | 0.367628 | 0.435 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.370880 | 0.431 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.377195 | 0.423 |
| R-HSA-202433 | Generation of second messenger molecules | 0.377195 | 0.423 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.377195 | 0.423 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.378196 | 0.422 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.379960 | 0.420 |
| R-HSA-70326 | Glucose metabolism | 0.379960 | 0.420 |
| R-HSA-9694548 | Maturation of spike protein | 0.383448 | 0.416 |
| R-HSA-5693538 | Homology Directed Repair | 0.383521 | 0.416 |
| R-HSA-913531 | Interferon Signaling | 0.383880 | 0.416 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.389638 | 0.409 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.389638 | 0.409 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.389638 | 0.409 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.389638 | 0.409 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.389638 | 0.409 |
| R-HSA-68875 | Mitotic Prophase | 0.390619 | 0.408 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.394154 | 0.404 |
| R-HSA-3371556 | Cellular response to heat stress | 0.394154 | 0.404 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.395766 | 0.403 |
| R-HSA-73928 | Depyrimidination | 0.395766 | 0.403 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.404704 | 0.393 |
| R-HSA-190828 | Gap junction trafficking | 0.407840 | 0.390 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.407840 | 0.390 |
| R-HSA-69206 | G1/S Transition | 0.411689 | 0.385 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.413787 | 0.383 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.413787 | 0.383 |
| R-HSA-114608 | Platelet degranulation | 0.418634 | 0.378 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.419674 | 0.377 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.419674 | 0.377 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.419674 | 0.377 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.419674 | 0.377 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.419674 | 0.377 |
| R-HSA-1266738 | Developmental Biology | 0.421686 | 0.375 |
| R-HSA-68882 | Mitotic Anaphase | 0.424264 | 0.372 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.425503 | 0.371 |
| R-HSA-437239 | Recycling pathway of L1 | 0.425503 | 0.371 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.426922 | 0.370 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.431273 | 0.365 |
| R-HSA-9843745 | Adipogenesis | 0.435812 | 0.361 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.436986 | 0.360 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.442608 | 0.354 |
| R-HSA-1640170 | Cell Cycle | 0.452043 | 0.345 |
| R-HSA-162906 | HIV Infection | 0.453265 | 0.344 |
| R-HSA-72187 | mRNA 3'-end processing | 0.453784 | 0.343 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.453784 | 0.343 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.471411 | 0.327 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.475410 | 0.323 |
| R-HSA-177929 | Signaling by EGFR | 0.475410 | 0.323 |
| R-HSA-75893 | TNF signaling | 0.475410 | 0.323 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.479156 | 0.320 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.479156 | 0.320 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.491069 | 0.309 |
| R-HSA-9033241 | Peroxisomal protein import | 0.491069 | 0.309 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.491069 | 0.309 |
| R-HSA-180786 | Extension of Telomeres | 0.491069 | 0.309 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.492083 | 0.308 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.496184 | 0.304 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.498471 | 0.302 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.501249 | 0.300 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.504808 | 0.297 |
| R-HSA-1268020 | Mitochondrial protein import | 0.506263 | 0.296 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.506263 | 0.296 |
| R-HSA-373755 | Semaphorin interactions | 0.511227 | 0.291 |
| R-HSA-9609646 | HCMV Infection | 0.511829 | 0.291 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.514217 | 0.289 |
| R-HSA-1989781 | PPARA activates gene expression | 0.520424 | 0.284 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.520424 | 0.284 |
| R-HSA-5688426 | Deubiquitination | 0.524128 | 0.281 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.525822 | 0.279 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.526578 | 0.279 |
| R-HSA-9610379 | HCMV Late Events | 0.526578 | 0.279 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.529635 | 0.276 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.530591 | 0.275 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.530591 | 0.275 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.531426 | 0.275 |
| R-HSA-877300 | Interferon gamma signaling | 0.532679 | 0.274 |
| R-HSA-74160 | Gene expression (Transcription) | 0.537542 | 0.270 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.543452 | 0.265 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.544612 | 0.264 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.544612 | 0.264 |
| R-HSA-416476 | G alpha (q) signalling events | 0.545835 | 0.263 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.547698 | 0.261 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.553727 | 0.257 |
| R-HSA-5619102 | SLC transporter disorders | 0.556547 | 0.254 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.562661 | 0.250 |
| R-HSA-8852135 | Protein ubiquitination | 0.567061 | 0.246 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.567061 | 0.246 |
| R-HSA-5689603 | UCH proteinases | 0.571417 | 0.243 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.575730 | 0.240 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.579999 | 0.237 |
| R-HSA-4086400 | PCP/CE pathway | 0.579999 | 0.237 |
| R-HSA-9833482 | PKR-mediated signaling | 0.588410 | 0.230 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.592553 | 0.227 |
| R-HSA-168255 | Influenza Infection | 0.593472 | 0.227 |
| R-HSA-2559583 | Cellular Senescence | 0.596216 | 0.225 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.604734 | 0.218 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.604734 | 0.218 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.608713 | 0.216 |
| R-HSA-69275 | G2/M Transition | 0.612392 | 0.213 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.617673 | 0.209 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.620414 | 0.207 |
| R-HSA-212436 | Generic Transcription Pathway | 0.625005 | 0.204 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.625493 | 0.204 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.629239 | 0.201 |
| R-HSA-68877 | Mitotic Prometaphase | 0.630637 | 0.200 |
| R-HSA-202424 | Downstream TCR signaling | 0.631766 | 0.199 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.633188 | 0.198 |
| R-HSA-8953854 | Metabolism of RNA | 0.634302 | 0.198 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.642782 | 0.192 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.642782 | 0.192 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.646380 | 0.190 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.649943 | 0.187 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.649943 | 0.187 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.653469 | 0.185 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.655539 | 0.183 |
| R-HSA-1500931 | Cell-Cell communication | 0.659263 | 0.181 |
| R-HSA-72172 | mRNA Splicing | 0.660357 | 0.180 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.660417 | 0.180 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.660417 | 0.180 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.662419 | 0.179 |
| R-HSA-157579 | Telomere Maintenance | 0.663839 | 0.178 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.667227 | 0.176 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.667227 | 0.176 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.667227 | 0.176 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.667227 | 0.176 |
| R-HSA-199991 | Membrane Trafficking | 0.668585 | 0.175 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.680441 | 0.167 |
| R-HSA-1483255 | PI Metabolism | 0.680441 | 0.167 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.681376 | 0.167 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.683663 | 0.165 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.686852 | 0.163 |
| R-HSA-9833110 | RSV-host interactions | 0.690009 | 0.161 |
| R-HSA-69239 | Synthesis of DNA | 0.699291 | 0.155 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.702324 | 0.153 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.705326 | 0.152 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.705326 | 0.152 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.714048 | 0.146 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.714153 | 0.146 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.717036 | 0.144 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.719967 | 0.143 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.725514 | 0.139 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.728284 | 0.138 |
| R-HSA-373760 | L1CAM interactions | 0.731025 | 0.136 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.732280 | 0.135 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.736427 | 0.133 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.739087 | 0.131 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.739087 | 0.131 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.739087 | 0.131 |
| R-HSA-73886 | Chromosome Maintenance | 0.744327 | 0.128 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.746908 | 0.127 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.746908 | 0.127 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.749463 | 0.125 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.749463 | 0.125 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.751379 | 0.124 |
| R-HSA-69481 | G2/M Checkpoints | 0.761858 | 0.118 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.769001 | 0.114 |
| R-HSA-68886 | M Phase | 0.773445 | 0.112 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.787024 | 0.104 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.787024 | 0.104 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.787715 | 0.104 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.789176 | 0.103 |
| R-HSA-5368287 | Mitochondrial translation | 0.791307 | 0.102 |
| R-HSA-6807070 | PTEN Regulation | 0.793416 | 0.100 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.811471 | 0.091 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.817133 | 0.088 |
| R-HSA-69306 | DNA Replication | 0.822627 | 0.085 |
| R-HSA-2262752 | Cellular responses to stress | 0.826748 | 0.083 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.827552 | 0.082 |
| R-HSA-9679506 | SARS-CoV Infections | 0.834509 | 0.079 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.834816 | 0.078 |
| R-HSA-109581 | Apoptosis | 0.838143 | 0.077 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.844989 | 0.073 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.853805 | 0.069 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.855285 | 0.068 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.856751 | 0.067 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.856751 | 0.067 |
| R-HSA-8957322 | Metabolism of steroids | 0.862773 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.866801 | 0.062 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.881208 | 0.055 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.891207 | 0.050 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.893404 | 0.049 |
| R-HSA-5357801 | Programmed Cell Death | 0.897666 | 0.047 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.904722 | 0.043 |
| R-HSA-397014 | Muscle contraction | 0.904722 | 0.043 |
| R-HSA-388396 | GPCR downstream signalling | 0.905955 | 0.043 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.906519 | 0.043 |
| R-HSA-8939211 | ESR-mediated signaling | 0.926195 | 0.033 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.939232 | 0.027 |
| R-HSA-372790 | Signaling by GPCR | 0.944009 | 0.025 |
| R-HSA-9824446 | Viral Infection Pathways | 0.947606 | 0.023 |
| R-HSA-446728 | Cell junction organization | 0.951493 | 0.022 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.953441 | 0.021 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.954045 | 0.020 |
| R-HSA-6798695 | Neutrophil degranulation | 0.954826 | 0.020 |
| R-HSA-1483257 | Phospholipid metabolism | 0.959253 | 0.018 |
| R-HSA-449147 | Signaling by Interleukins | 0.959786 | 0.018 |
| R-HSA-1280218 | Adaptive Immune System | 0.960961 | 0.017 |
| R-HSA-168249 | Innate Immune System | 0.966127 | 0.015 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.969436 | 0.013 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.979751 | 0.009 |
| R-HSA-5663205 | Infectious disease | 0.981884 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.983693 | 0.007 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.989102 | 0.005 |
| R-HSA-72766 | Translation | 0.989863 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.989998 | 0.004 |
| R-HSA-112316 | Neuronal System | 0.993233 | 0.003 |
| R-HSA-168256 | Immune System | 0.997328 | 0.001 |
| R-HSA-1643685 | Disease | 0.998156 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999614 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999645 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999981 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.842 | 0.793 | 1 | 0.830 |
CDK18 |
0.841 | 0.849 | 1 | 0.856 |
CDK17 |
0.834 | 0.836 | 1 | 0.886 |
KIS |
0.831 | 0.744 | 1 | 0.783 |
CDK19 |
0.831 | 0.830 | 1 | 0.837 |
P38G |
0.828 | 0.838 | 1 | 0.894 |
P38D |
0.826 | 0.836 | 1 | 0.890 |
CDK3 |
0.826 | 0.720 | 1 | 0.884 |
CDK16 |
0.825 | 0.801 | 1 | 0.874 |
P38B |
0.824 | 0.857 | 1 | 0.824 |
JNK2 |
0.824 | 0.841 | 1 | 0.855 |
CDK7 |
0.824 | 0.812 | 1 | 0.816 |
CDK1 |
0.824 | 0.789 | 1 | 0.844 |
ERK1 |
0.822 | 0.833 | 1 | 0.834 |
CDK8 |
0.822 | 0.819 | 1 | 0.804 |
DYRK4 |
0.821 | 0.761 | 1 | 0.847 |
DYRK2 |
0.819 | 0.759 | 1 | 0.751 |
CDK5 |
0.814 | 0.768 | 1 | 0.789 |
CDK10 |
0.813 | 0.732 | 1 | 0.831 |
CDK13 |
0.812 | 0.775 | 1 | 0.833 |
HIPK1 |
0.812 | 0.705 | 1 | 0.730 |
CDK14 |
0.812 | 0.786 | 1 | 0.815 |
CDK12 |
0.811 | 0.776 | 1 | 0.850 |
HIPK4 |
0.811 | 0.596 | 1 | 0.537 |
P38A |
0.810 | 0.829 | 1 | 0.753 |
CLK3 |
0.810 | 0.530 | 1 | 0.527 |
JNK3 |
0.809 | 0.814 | 1 | 0.830 |
DYRK1B |
0.806 | 0.714 | 1 | 0.803 |
MAK |
0.805 | 0.633 | -2 | 0.900 |
CDK9 |
0.802 | 0.752 | 1 | 0.824 |
DYRK1A |
0.799 | 0.641 | 1 | 0.713 |
JNK1 |
0.798 | 0.740 | 1 | 0.862 |
HIPK3 |
0.797 | 0.682 | 1 | 0.694 |
ERK2 |
0.794 | 0.780 | 1 | 0.785 |
CDK4 |
0.792 | 0.758 | 1 | 0.857 |
CLK2 |
0.792 | 0.412 | -3 | 0.696 |
SRPK1 |
0.791 | 0.346 | -3 | 0.697 |
CDK6 |
0.791 | 0.731 | 1 | 0.829 |
NLK |
0.790 | 0.699 | 1 | 0.552 |
DYRK3 |
0.786 | 0.540 | 1 | 0.690 |
ERK5 |
0.782 | 0.441 | 1 | 0.474 |
ICK |
0.780 | 0.471 | -3 | 0.776 |
CDKL5 |
0.779 | 0.275 | -3 | 0.730 |
MOK |
0.779 | 0.544 | 1 | 0.619 |
CLK1 |
0.778 | 0.393 | -3 | 0.670 |
CDK2 |
0.777 | 0.562 | 1 | 0.724 |
SRPK2 |
0.776 | 0.269 | -3 | 0.625 |
CLK4 |
0.775 | 0.363 | -3 | 0.695 |
MTOR |
0.774 | 0.279 | 1 | 0.343 |
CDKL1 |
0.767 | 0.221 | -3 | 0.733 |
PRP4 |
0.766 | 0.463 | -3 | 0.697 |
SRPK3 |
0.765 | 0.236 | -3 | 0.662 |
COT |
0.763 | -0.036 | 2 | 0.807 |
MOS |
0.761 | 0.078 | 1 | 0.249 |
CDC7 |
0.758 | -0.028 | 1 | 0.219 |
NDR2 |
0.757 | 0.046 | -3 | 0.809 |
PRKD1 |
0.756 | 0.065 | -3 | 0.785 |
PIM3 |
0.755 | 0.013 | -3 | 0.792 |
ERK7 |
0.752 | 0.277 | 2 | 0.535 |
PRKD2 |
0.751 | 0.045 | -3 | 0.733 |
PRPK |
0.751 | -0.028 | -1 | 0.788 |
TBK1 |
0.750 | -0.087 | 1 | 0.136 |
ATR |
0.749 | -0.002 | 1 | 0.224 |
CHAK2 |
0.749 | 0.021 | -1 | 0.756 |
RSK2 |
0.748 | 0.016 | -3 | 0.717 |
AURC |
0.748 | 0.037 | -2 | 0.584 |
SKMLCK |
0.747 | 0.008 | -2 | 0.788 |
GRK1 |
0.747 | 0.027 | -2 | 0.727 |
MST4 |
0.745 | -0.030 | 2 | 0.830 |
IKKE |
0.745 | -0.124 | 1 | 0.136 |
WNK1 |
0.744 | -0.051 | -2 | 0.808 |
P90RSK |
0.744 | 0.016 | -3 | 0.714 |
MAPKAPK2 |
0.744 | 0.006 | -3 | 0.701 |
PIM1 |
0.744 | 0.030 | -3 | 0.737 |
MPSK1 |
0.744 | 0.205 | 1 | 0.219 |
NUAK2 |
0.743 | 0.002 | -3 | 0.773 |
NDR1 |
0.743 | -0.031 | -3 | 0.777 |
IKKB |
0.743 | -0.145 | -2 | 0.653 |
CAMK1B |
0.743 | -0.039 | -3 | 0.766 |
RSK3 |
0.741 | -0.007 | -3 | 0.702 |
PKN3 |
0.741 | -0.040 | -3 | 0.757 |
RAF1 |
0.741 | -0.170 | 1 | 0.172 |
MAPKAPK3 |
0.740 | -0.022 | -3 | 0.728 |
PKN2 |
0.739 | -0.058 | -3 | 0.758 |
NEK6 |
0.739 | -0.065 | -2 | 0.745 |
GSK3A |
0.739 | 0.227 | 4 | 0.476 |
BMPR2 |
0.739 | -0.154 | -2 | 0.775 |
GRK7 |
0.739 | 0.034 | 1 | 0.212 |
GCN2 |
0.739 | -0.191 | 2 | 0.732 |
NIK |
0.738 | -0.050 | -3 | 0.785 |
CAMLCK |
0.738 | -0.004 | -2 | 0.756 |
PDHK4 |
0.738 | -0.162 | 1 | 0.233 |
PKCD |
0.738 | -0.013 | 2 | 0.727 |
BMPR1B |
0.738 | -0.025 | 1 | 0.193 |
DAPK2 |
0.738 | -0.021 | -3 | 0.778 |
MLK2 |
0.736 | -0.012 | 2 | 0.753 |
RIPK3 |
0.736 | -0.109 | 3 | 0.662 |
PKACG |
0.736 | -0.030 | -2 | 0.649 |
RSK4 |
0.736 | 0.025 | -3 | 0.708 |
LATS2 |
0.736 | -0.032 | -5 | 0.703 |
TGFBR2 |
0.736 | -0.092 | -2 | 0.685 |
P70S6KB |
0.735 | -0.012 | -3 | 0.718 |
MLK3 |
0.735 | -0.002 | 2 | 0.695 |
MNK2 |
0.734 | -0.017 | -2 | 0.698 |
IRE1 |
0.734 | -0.067 | 1 | 0.147 |
IKKA |
0.734 | -0.071 | -2 | 0.660 |
PKACB |
0.734 | 0.021 | -2 | 0.585 |
AMPKA1 |
0.734 | -0.060 | -3 | 0.789 |
PKCB |
0.734 | -0.013 | 2 | 0.685 |
MLK1 |
0.733 | -0.115 | 2 | 0.757 |
PKCA |
0.733 | 0.012 | 2 | 0.679 |
ULK2 |
0.732 | -0.213 | 2 | 0.711 |
LATS1 |
0.732 | 0.046 | -3 | 0.824 |
PHKG1 |
0.732 | -0.043 | -3 | 0.765 |
PKCG |
0.732 | -0.020 | 2 | 0.691 |
CAMK2D |
0.732 | -0.081 | -3 | 0.764 |
GRK5 |
0.731 | -0.136 | -3 | 0.772 |
DSTYK |
0.731 | -0.199 | 2 | 0.826 |
CAMK2G |
0.731 | -0.128 | 2 | 0.744 |
MNK1 |
0.731 | -0.009 | -2 | 0.701 |
PRKD3 |
0.731 | -0.004 | -3 | 0.675 |
AKT2 |
0.731 | 0.028 | -3 | 0.634 |
AMPKA2 |
0.730 | -0.040 | -3 | 0.762 |
MARK4 |
0.730 | -0.079 | 4 | 0.788 |
PDHK1 |
0.730 | -0.190 | 1 | 0.206 |
PKG2 |
0.729 | -0.007 | -2 | 0.589 |
PAK1 |
0.729 | -0.034 | -2 | 0.715 |
TSSK1 |
0.729 | -0.040 | -3 | 0.813 |
CK1E |
0.729 | 0.023 | -3 | 0.563 |
BUB1 |
0.728 | 0.142 | -5 | 0.808 |
PKCZ |
0.728 | -0.028 | 2 | 0.721 |
DNAPK |
0.728 | -0.030 | 1 | 0.199 |
MASTL |
0.728 | -0.148 | -2 | 0.725 |
CAMK2A |
0.728 | -0.016 | 2 | 0.738 |
NEK7 |
0.727 | -0.203 | -3 | 0.752 |
SGK3 |
0.726 | -0.007 | -3 | 0.708 |
TGFBR1 |
0.726 | -0.052 | -2 | 0.708 |
PAK3 |
0.726 | -0.062 | -2 | 0.699 |
PRKX |
0.726 | 0.021 | -3 | 0.653 |
DLK |
0.726 | -0.158 | 1 | 0.181 |
VRK2 |
0.725 | 0.087 | 1 | 0.264 |
ALK4 |
0.725 | -0.065 | -2 | 0.732 |
PIM2 |
0.725 | 0.023 | -3 | 0.678 |
AURB |
0.725 | -0.020 | -2 | 0.576 |
TSSK2 |
0.724 | -0.091 | -5 | 0.817 |
SMG1 |
0.724 | -0.059 | 1 | 0.203 |
IRE2 |
0.724 | -0.070 | 2 | 0.686 |
WNK3 |
0.724 | -0.210 | 1 | 0.155 |
NEK9 |
0.723 | -0.176 | 2 | 0.772 |
PAK6 |
0.723 | -0.023 | -2 | 0.623 |
PKR |
0.722 | -0.078 | 1 | 0.178 |
CAMK2B |
0.722 | -0.066 | 2 | 0.713 |
CK1D |
0.722 | 0.040 | -3 | 0.518 |
MSK2 |
0.722 | -0.051 | -3 | 0.695 |
HUNK |
0.722 | -0.199 | 2 | 0.754 |
MST3 |
0.722 | -0.015 | 2 | 0.808 |
ULK1 |
0.721 | -0.208 | -3 | 0.705 |
TTBK2 |
0.721 | -0.173 | 2 | 0.652 |
MSK1 |
0.721 | -0.027 | -3 | 0.693 |
NIM1 |
0.721 | -0.111 | 3 | 0.674 |
BCKDK |
0.721 | -0.175 | -1 | 0.662 |
MELK |
0.720 | -0.088 | -3 | 0.733 |
ATM |
0.720 | -0.098 | 1 | 0.194 |
GRK6 |
0.720 | -0.165 | 1 | 0.185 |
YSK4 |
0.720 | -0.138 | 1 | 0.148 |
RIPK1 |
0.719 | -0.206 | 1 | 0.144 |
PKCH |
0.719 | -0.067 | 2 | 0.664 |
QSK |
0.719 | -0.053 | 4 | 0.770 |
DCAMKL1 |
0.719 | -0.044 | -3 | 0.736 |
PASK |
0.719 | 0.019 | -3 | 0.815 |
CAMK4 |
0.719 | -0.135 | -3 | 0.743 |
CHAK1 |
0.718 | -0.120 | 2 | 0.719 |
MLK4 |
0.718 | -0.084 | 2 | 0.662 |
NUAK1 |
0.718 | -0.066 | -3 | 0.716 |
GSK3B |
0.718 | 0.071 | 4 | 0.475 |
ANKRD3 |
0.717 | -0.211 | 1 | 0.178 |
ACVR2B |
0.717 | -0.100 | -2 | 0.682 |
MYLK4 |
0.717 | -0.055 | -2 | 0.674 |
PINK1 |
0.717 | 0.095 | 1 | 0.368 |
FAM20C |
0.717 | -0.037 | 2 | 0.578 |
AURA |
0.716 | -0.038 | -2 | 0.554 |
PAK2 |
0.716 | -0.076 | -2 | 0.694 |
TAO3 |
0.716 | -0.019 | 1 | 0.192 |
AKT1 |
0.715 | -0.002 | -3 | 0.658 |
CK1A2 |
0.715 | 0.011 | -3 | 0.519 |
MEK1 |
0.715 | -0.162 | 2 | 0.779 |
TLK2 |
0.715 | -0.105 | 1 | 0.147 |
ACVR2A |
0.714 | -0.113 | -2 | 0.669 |
NEK2 |
0.714 | -0.142 | 2 | 0.761 |
GRK4 |
0.714 | -0.180 | -2 | 0.728 |
DRAK1 |
0.714 | -0.130 | 1 | 0.165 |
GRK2 |
0.714 | -0.084 | -2 | 0.643 |
QIK |
0.713 | -0.136 | -3 | 0.746 |
CK1G1 |
0.713 | -0.029 | -3 | 0.538 |
PKACA |
0.713 | -0.008 | -2 | 0.540 |
SIK |
0.713 | -0.073 | -3 | 0.690 |
BRSK2 |
0.713 | -0.099 | -3 | 0.737 |
BRSK1 |
0.713 | -0.083 | -3 | 0.724 |
PKCE |
0.713 | -0.005 | 2 | 0.683 |
BMPR1A |
0.712 | -0.069 | 1 | 0.184 |
ALK2 |
0.712 | -0.096 | -2 | 0.712 |
MARK3 |
0.711 | -0.069 | 4 | 0.720 |
PKCT |
0.711 | -0.062 | 2 | 0.667 |
WNK4 |
0.711 | -0.111 | -2 | 0.806 |
MAPKAPK5 |
0.710 | -0.100 | -3 | 0.656 |
AKT3 |
0.710 | 0.017 | -3 | 0.598 |
CAMK1G |
0.710 | -0.078 | -3 | 0.682 |
PKCI |
0.710 | -0.044 | 2 | 0.702 |
CHK1 |
0.710 | -0.076 | -3 | 0.771 |
PLK4 |
0.710 | -0.132 | 2 | 0.567 |
MEK5 |
0.710 | -0.146 | 2 | 0.755 |
LKB1 |
0.709 | 0.010 | -3 | 0.756 |
PHKG2 |
0.708 | -0.095 | -3 | 0.707 |
NEK5 |
0.708 | -0.121 | 1 | 0.151 |
GCK |
0.708 | -0.025 | 1 | 0.176 |
IRAK4 |
0.708 | -0.122 | 1 | 0.126 |
MAP3K15 |
0.707 | -0.021 | 1 | 0.159 |
SGK1 |
0.707 | 0.027 | -3 | 0.574 |
PLK1 |
0.707 | -0.199 | -2 | 0.671 |
GAK |
0.707 | -0.038 | 1 | 0.229 |
PAK5 |
0.706 | -0.047 | -2 | 0.574 |
NEK11 |
0.706 | -0.109 | 1 | 0.183 |
DCAMKL2 |
0.706 | -0.075 | -3 | 0.733 |
P70S6K |
0.706 | -0.041 | -3 | 0.635 |
SSTK |
0.706 | -0.069 | 4 | 0.770 |
ZAK |
0.706 | -0.163 | 1 | 0.150 |
MEKK2 |
0.705 | -0.138 | 2 | 0.731 |
PAK4 |
0.704 | -0.037 | -2 | 0.585 |
MEKK1 |
0.704 | -0.161 | 1 | 0.163 |
SBK |
0.704 | 0.097 | -3 | 0.535 |
PBK |
0.704 | -0.002 | 1 | 0.205 |
SMMLCK |
0.703 | -0.065 | -3 | 0.728 |
PERK |
0.703 | -0.175 | -2 | 0.719 |
HPK1 |
0.703 | -0.051 | 1 | 0.174 |
MEKK6 |
0.703 | -0.068 | 1 | 0.163 |
PKN1 |
0.703 | -0.046 | -3 | 0.654 |
PDK1 |
0.702 | -0.063 | 1 | 0.195 |
TAO2 |
0.702 | -0.065 | 2 | 0.786 |
MEKK3 |
0.702 | -0.201 | 1 | 0.167 |
TNIK |
0.702 | -0.020 | 3 | 0.823 |
MARK2 |
0.702 | -0.102 | 4 | 0.680 |
GRK3 |
0.702 | -0.085 | -2 | 0.606 |
HASPIN |
0.701 | 0.031 | -1 | 0.642 |
KHS1 |
0.701 | -0.011 | 1 | 0.159 |
DAPK3 |
0.701 | -0.045 | -3 | 0.735 |
ROCK2 |
0.701 | 0.001 | -3 | 0.728 |
SNRK |
0.701 | -0.193 | 2 | 0.607 |
KHS2 |
0.701 | -0.006 | 1 | 0.174 |
HGK |
0.700 | -0.056 | 3 | 0.811 |
TLK1 |
0.700 | -0.168 | -2 | 0.719 |
CK2A2 |
0.699 | -0.077 | 1 | 0.190 |
HRI |
0.699 | -0.208 | -2 | 0.728 |
CAMKK2 |
0.699 | -0.101 | -2 | 0.670 |
MRCKB |
0.698 | -0.014 | -3 | 0.663 |
PLK3 |
0.698 | -0.178 | 2 | 0.706 |
LOK |
0.697 | -0.058 | -2 | 0.668 |
DAPK1 |
0.697 | -0.050 | -3 | 0.715 |
CHK2 |
0.697 | -0.030 | -3 | 0.583 |
EEF2K |
0.697 | -0.064 | 3 | 0.759 |
LRRK2 |
0.697 | -0.028 | 2 | 0.789 |
CAMK1D |
0.696 | -0.060 | -3 | 0.629 |
MARK1 |
0.696 | -0.130 | 4 | 0.738 |
MINK |
0.696 | -0.107 | 1 | 0.141 |
NEK4 |
0.695 | -0.142 | 1 | 0.133 |
MRCKA |
0.695 | -0.027 | -3 | 0.684 |
BRAF |
0.695 | -0.202 | -4 | 0.765 |
SLK |
0.694 | -0.057 | -2 | 0.632 |
DMPK1 |
0.694 | 0.015 | -3 | 0.695 |
NEK8 |
0.694 | -0.188 | 2 | 0.757 |
CK2A1 |
0.693 | -0.077 | 1 | 0.184 |
TTBK1 |
0.693 | -0.176 | 2 | 0.577 |
MST2 |
0.692 | -0.139 | 1 | 0.162 |
NEK1 |
0.692 | -0.114 | 1 | 0.130 |
CAMKK1 |
0.692 | -0.195 | -2 | 0.662 |
CRIK |
0.691 | 0.022 | -3 | 0.671 |
VRK1 |
0.691 | -0.122 | 2 | 0.776 |
PDHK3_TYR |
0.691 | 0.226 | 4 | 0.857 |
AAK1 |
0.690 | 0.028 | 1 | 0.218 |
CAMK1A |
0.689 | -0.041 | -3 | 0.601 |
LIMK2_TYR |
0.689 | 0.201 | -3 | 0.806 |
CK1A |
0.686 | -0.002 | -3 | 0.441 |
YSK1 |
0.686 | -0.105 | 2 | 0.757 |
BIKE |
0.686 | -0.021 | 1 | 0.215 |
TAK1 |
0.686 | -0.188 | 1 | 0.154 |
MST1 |
0.685 | -0.139 | 1 | 0.145 |
STK33 |
0.684 | -0.139 | 2 | 0.567 |
ROCK1 |
0.684 | -0.028 | -3 | 0.682 |
TESK1_TYR |
0.683 | 0.107 | 3 | 0.809 |
PDHK4_TYR |
0.683 | 0.119 | 2 | 0.813 |
OSR1 |
0.683 | -0.061 | 2 | 0.742 |
PKMYT1_TYR |
0.681 | 0.139 | 3 | 0.773 |
YANK3 |
0.680 | -0.045 | 2 | 0.387 |
PKG1 |
0.680 | -0.062 | -2 | 0.502 |
MAP2K4_TYR |
0.680 | 0.064 | -1 | 0.790 |
MYO3B |
0.679 | -0.056 | 2 | 0.779 |
IRAK1 |
0.679 | -0.281 | -1 | 0.651 |
ASK1 |
0.677 | -0.089 | 1 | 0.161 |
TAO1 |
0.677 | -0.076 | 1 | 0.146 |
NEK3 |
0.677 | -0.140 | 1 | 0.148 |
MAP2K6_TYR |
0.677 | 0.038 | -1 | 0.791 |
PLK2 |
0.675 | -0.118 | -3 | 0.666 |
MEK2 |
0.675 | -0.220 | 2 | 0.740 |
PDHK1_TYR |
0.675 | 0.011 | -1 | 0.806 |
MAP2K7_TYR |
0.674 | -0.054 | 2 | 0.790 |
TTK |
0.673 | -0.108 | -2 | 0.701 |
BMPR2_TYR |
0.672 | -0.001 | -1 | 0.792 |
MYO3A |
0.672 | -0.091 | 1 | 0.152 |
ABL2 |
0.670 | -0.021 | -1 | 0.733 |
TXK |
0.670 | -0.023 | 1 | 0.185 |
ALPHAK3 |
0.669 | -0.087 | -1 | 0.692 |
RIPK2 |
0.669 | -0.265 | 1 | 0.132 |
PINK1_TYR |
0.669 | -0.130 | 1 | 0.225 |
RET |
0.669 | -0.077 | 1 | 0.178 |
LIMK1_TYR |
0.669 | 0.004 | 2 | 0.783 |
MST1R |
0.668 | -0.050 | 3 | 0.751 |
CSF1R |
0.667 | -0.028 | 3 | 0.730 |
EPHA6 |
0.667 | -0.063 | -1 | 0.768 |
ABL1 |
0.666 | -0.034 | -1 | 0.728 |
EPHB4 |
0.666 | -0.053 | -1 | 0.726 |
JAK2 |
0.666 | -0.057 | 1 | 0.184 |
LCK |
0.665 | -0.035 | -1 | 0.795 |
TNK2 |
0.664 | -0.037 | 3 | 0.700 |
JAK1 |
0.663 | -0.032 | 1 | 0.152 |
BLK |
0.663 | -0.036 | -1 | 0.798 |
ROS1 |
0.662 | -0.090 | 3 | 0.692 |
YES1 |
0.662 | -0.073 | -1 | 0.798 |
FGR |
0.662 | -0.111 | 1 | 0.168 |
TYRO3 |
0.662 | -0.116 | 3 | 0.725 |
NEK10_TYR |
0.661 | -0.073 | 1 | 0.152 |
TYK2 |
0.660 | -0.176 | 1 | 0.163 |
JAK3 |
0.660 | -0.102 | 1 | 0.176 |
TNNI3K_TYR |
0.659 | -0.019 | 1 | 0.185 |
TNK1 |
0.658 | -0.029 | 3 | 0.708 |
HCK |
0.658 | -0.105 | -1 | 0.783 |
KDR |
0.657 | -0.063 | 3 | 0.690 |
DDR1 |
0.656 | -0.124 | 4 | 0.791 |
MET |
0.656 | -0.054 | 3 | 0.732 |
ITK |
0.656 | -0.098 | -1 | 0.728 |
KIT |
0.655 | -0.093 | 3 | 0.725 |
EPHA4 |
0.655 | -0.069 | 2 | 0.723 |
FGFR2 |
0.655 | -0.058 | 3 | 0.704 |
FYN |
0.654 | -0.051 | -1 | 0.793 |
BMX |
0.654 | -0.081 | -1 | 0.671 |
STLK3 |
0.653 | -0.187 | 1 | 0.133 |
SRMS |
0.652 | -0.144 | 1 | 0.170 |
TEK |
0.652 | -0.036 | 3 | 0.645 |
MERTK |
0.651 | -0.110 | 3 | 0.707 |
FER |
0.651 | -0.183 | 1 | 0.192 |
FGFR1 |
0.651 | -0.065 | 3 | 0.677 |
CK1G3 |
0.650 | -0.035 | -3 | 0.397 |
INSRR |
0.650 | -0.150 | 3 | 0.654 |
EPHB1 |
0.650 | -0.147 | 1 | 0.171 |
EPHB3 |
0.649 | -0.132 | -1 | 0.709 |
YANK2 |
0.648 | -0.062 | 2 | 0.395 |
FRK |
0.648 | -0.111 | -1 | 0.784 |
DDR2 |
0.647 | -0.018 | 3 | 0.643 |
EPHB2 |
0.647 | -0.129 | -1 | 0.708 |
PTK2B |
0.647 | -0.068 | -1 | 0.709 |
AXL |
0.647 | -0.142 | 3 | 0.703 |
PDGFRB |
0.646 | -0.193 | 3 | 0.733 |
FLT3 |
0.646 | -0.180 | 3 | 0.725 |
WEE1_TYR |
0.646 | -0.096 | -1 | 0.658 |
TEC |
0.645 | -0.137 | -1 | 0.673 |
EPHA1 |
0.645 | -0.113 | 3 | 0.717 |
FGFR3 |
0.645 | -0.077 | 3 | 0.676 |
EPHA7 |
0.644 | -0.102 | 2 | 0.714 |
FLT1 |
0.644 | -0.122 | -1 | 0.727 |
PDGFRA |
0.643 | -0.179 | 3 | 0.731 |
ERBB2 |
0.642 | -0.156 | 1 | 0.162 |
BTK |
0.642 | -0.194 | -1 | 0.694 |
SRC |
0.641 | -0.101 | -1 | 0.780 |
PTK2 |
0.641 | -0.039 | -1 | 0.716 |
ALK |
0.641 | -0.151 | 3 | 0.628 |
LYN |
0.641 | -0.119 | 3 | 0.633 |
CK1G2 |
0.640 | -0.032 | -3 | 0.473 |
SYK |
0.639 | -0.061 | -1 | 0.707 |
EGFR |
0.638 | -0.106 | 1 | 0.138 |
EPHA3 |
0.638 | -0.131 | 2 | 0.686 |
MATK |
0.638 | -0.097 | -1 | 0.658 |
LTK |
0.638 | -0.166 | 3 | 0.656 |
EPHA8 |
0.638 | -0.098 | -1 | 0.715 |
ERBB4 |
0.635 | -0.076 | 1 | 0.153 |
ZAP70 |
0.635 | -0.022 | -1 | 0.636 |
PTK6 |
0.634 | -0.201 | -1 | 0.648 |
INSR |
0.634 | -0.170 | 3 | 0.640 |
FLT4 |
0.634 | -0.172 | 3 | 0.665 |
NTRK3 |
0.633 | -0.151 | -1 | 0.662 |
CSK |
0.633 | -0.124 | 2 | 0.715 |
FGFR4 |
0.633 | -0.103 | -1 | 0.673 |
EPHA5 |
0.632 | -0.137 | 2 | 0.694 |
NTRK1 |
0.632 | -0.227 | -1 | 0.702 |
MUSK |
0.629 | -0.137 | 1 | 0.120 |
NTRK2 |
0.628 | -0.236 | 3 | 0.669 |
EPHA2 |
0.627 | -0.111 | -1 | 0.670 |
IGF1R |
0.618 | -0.165 | 3 | 0.566 |
FES |
0.612 | -0.147 | -1 | 0.640 |