Motif 238 (n=120)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1B0GU03 | None | S350 | ochoa | Cathepsin D (EC 3.4.23.5) | None |
| A4FU49 | SH3D21 | S329 | ochoa | SH3 domain-containing protein 21 | None |
| A7MCY6 | TBKBP1 | S342 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| B8ZZF3 | None | S304 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| C9JRZ8 | AKR1B15 | S215 | ochoa | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493, ECO:0000269|PubMed:26222439}.; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. {ECO:0000269|PubMed:25577493}. |
| O00512 | BCL9 | S291 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14526 | FCHO1 | S479 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14654 | IRS4 | S859 | ochoa|psp | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S1180 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15213 | WDR46 | S41 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O15217 | GSTA4 | S189 | psp | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}. |
| O15389 | SIGLEC5 | S488 | ochoa | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| O15409 | FOXP2 | S439 | ochoa | Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| O43439 | CBFA2T2 | S44 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O43524 | FOXO3 | S30 | ochoa|psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60218 | AKR1B10 | S215 | ochoa | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}. |
| O60271 | SPAG9 | S564 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60308 | CEP104 | S314 | ochoa | Centrosomal protein of 104 kDa (Cep104) | Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}. |
| O60308 | CEP104 | S353 | ochoa | Centrosomal protein of 104 kDa (Cep104) | Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}. |
| O75064 | DENND4B | S1071 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75914 | PAK3 | S220 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| O75952 | CABYR | S141 | ochoa | Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86) | May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. |
| O94804 | STK10 | S392 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94868 | FCHSD2 | S646 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O95382 | MAP3K6 | S1144 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95402 | MED26 | S296 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| P04792 | HSPB1 | S49 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P08631 | HCK | S38 | ochoa | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P10636 | MAPT | S411 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P15121 | AKR1B1 | S215 | ochoa | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| P18583 | SON | S278 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18887 | XRCC1 | S259 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P19878 | NCF2 | S312 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P23588 | EIF4B | S459 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P27816 | MAP4 | S713 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P43403 | ZAP70 | S301 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46013 | MKI67 | S3128 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | S2087 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P52948 | NUP98 | S900 | ochoa|psp | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P85037 | FOXK1 | S203 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q01804 | OTUD4 | S557 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q03188 | CENPC | S277 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04206 | RELA | S316 | ochoa|psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q12815 | TROAP | S408 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12893 | TMEM115 | S320 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q13153 | PAK1 | S204 | ochoa|psp | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13459 | MYO9B | S1115 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13459 | MYO9B | S1261 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q14155 | ARHGEF7 | S581 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14839 | CHD4 | S1535 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q15652 | JMJD1C | S630 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q1MSJ5 | CSPP1 | S882 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
| Q2NKX8 | ERCC6L | S739 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q53GS9 | USP39 | S46 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q5JSZ5 | PRRC2B | S575 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5VST9 | OBSCN | S7244 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q6F5E8 | CARMIL2 | S1400 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6P1N0 | CC2D1A | S455 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6P4R8 | NFRKB | S339 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PII3 | CCDC174 | S432 | ochoa | Coiled-coil domain-containing protein 174 | Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}. |
| Q6PIY7 | TENT2 | S110 | psp | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
| Q6VMQ6 | ATF7IP | S477 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q7LDG7 | RASGRP2 | S394 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z3K3 | POGZ | S425 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z3U7 | MON2 | S1177 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q86UR1 | NOXA1 | S282 | psp | NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox) | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}. |
| Q86UU0 | BCL9L | S1010 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86XJ1 | GAS2L3 | S431 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IVT2 | MISP | S214 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IZ21 | PHACTR4 | S342 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S854 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N5H7 | SH2D3C | S463 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8NEY1 | NAV1 | S152 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NF64 | ZMIZ2 | S395 | ochoa | Zinc finger MIZ domain-containing protein 2 (PIAS-like protein Zimp7) | Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. {ECO:0000269|PubMed:16051670}. |
| Q8NFU7 | TET1 | S1971 | psp | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8TAP8 | PPP1R35 | S87 | ochoa | Protein phosphatase 1 regulatory subunit 35 | During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. |
| Q8TF30 | WHAMM | S606 | ochoa | WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}. |
| Q92576 | PHF3 | S1181 | ochoa | PHD finger protein 3 | None |
| Q96B54 | ZNF428 | S99 | ochoa | Zinc finger protein 428 (Enzyme-like protein PIT13) | None |
| Q96EP0 | RNF31 | S451 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96IF1 | AJUBA | S175 | ochoa|psp | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96J92 | WNK4 | S1022 | psp | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
| Q96JM3 | CHAMP1 | S142 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S164 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S184 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S204 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S264 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S275 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S286 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S297 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S308 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S319 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S330 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S344 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S355 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S405 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S416 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S427 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96PN7 | TRERF1 | S730 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96PX6 | CCDC85A | S289 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q96PY6 | NEK1 | S837 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96QC0 | PPP1R10 | S313 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q99956 | DUSP9 | S356 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BQE9 | BCL7B | S151 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
| Q9BQI5 | SGIP1 | S319 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BWT3 | PAPOLG | S599 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXF6 | RAB11FIP5 | S523 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXS6 | NUSAP1 | S333 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9BZL4 | PPP1R12C | S499 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0C9 | UBE2O | S836 | ochoa|psp | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H7N4 | SCAF1 | S535 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HBM6 | TAF9B | S152 | ochoa | Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L) | Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}. |
| Q9NQT8 | KIF13B | S1481 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9UHF7 | TRPS1 | S1066 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UI08 | EVL | S349 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9ULU4 | ZMYND8 | S652 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPV0 | CEP164 | S270 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UPV0 | CEP164 | S273 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y4G6 | TLN2 | S473 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y5S2 | CDC42BPB | S1677 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000283 | 3.548 |
| R-HSA-202433 | Generation of second messenger molecules | 0.000363 | 3.441 |
| R-HSA-3928664 | Ephrin signaling | 0.000607 | 3.217 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.001299 | 2.886 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.001274 | 2.895 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.002178 | 2.662 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.002352 | 2.629 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.002352 | 2.629 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.002727 | 2.564 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.002727 | 2.564 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.002927 | 2.534 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.003355 | 2.474 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004319 | 2.365 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.004584 | 2.339 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.003818 | 2.418 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.002927 | 2.534 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.003136 | 2.504 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.004858 | 2.314 |
| R-HSA-428540 | Activation of RAC1 | 0.005126 | 2.290 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.004584 | 2.339 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.004584 | 2.339 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.004858 | 2.314 |
| R-HSA-202403 | TCR signaling | 0.001780 | 2.750 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.004064 | 2.391 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.004348 | 2.362 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.004319 | 2.365 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.005606 | 2.251 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.006377 | 2.195 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.006525 | 2.185 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.006710 | 2.173 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.008077 | 2.093 |
| R-HSA-162587 | HIV Life Cycle | 0.008083 | 2.092 |
| R-HSA-162906 | HIV Infection | 0.008170 | 2.088 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.008522 | 2.069 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.010682 | 1.971 |
| R-HSA-191859 | snRNP Assembly | 0.012006 | 1.921 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.012006 | 1.921 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.011073 | 1.956 |
| R-HSA-4839726 | Chromatin organization | 0.012059 | 1.919 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.012983 | 1.887 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.013299 | 1.876 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.013488 | 1.870 |
| R-HSA-3371556 | Cellular response to heat stress | 0.015455 | 1.811 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.016610 | 1.780 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.019779 | 1.704 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.019151 | 1.718 |
| R-HSA-194138 | Signaling by VEGF | 0.017410 | 1.759 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.021069 | 1.676 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.025941 | 1.586 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.028973 | 1.538 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.028973 | 1.538 |
| R-HSA-73887 | Death Receptor Signaling | 0.033534 | 1.475 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.033534 | 1.475 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.033904 | 1.470 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.034407 | 1.463 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.034483 | 1.462 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.034483 | 1.462 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.035576 | 1.449 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.041237 | 1.385 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.043555 | 1.361 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.041237 | 1.385 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.042888 | 1.368 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.054605 | 1.263 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.054605 | 1.263 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.054605 | 1.263 |
| R-HSA-167161 | HIV Transcription Initiation | 0.046918 | 1.329 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.046918 | 1.329 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.053919 | 1.268 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.050374 | 1.298 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.047945 | 1.319 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.046918 | 1.329 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.045810 | 1.339 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.043851 | 1.358 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.045225 | 1.345 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.054605 | 1.263 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.047945 | 1.319 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.054068 | 1.267 |
| R-HSA-9607240 | FLT3 Signaling | 0.045225 | 1.345 |
| R-HSA-70171 | Glycolysis | 0.043851 | 1.358 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.054568 | 1.263 |
| R-HSA-162582 | Signal Transduction | 0.047856 | 1.320 |
| R-HSA-211000 | Gene Silencing by RNA | 0.051941 | 1.284 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.057338 | 1.242 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.059396 | 1.226 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.059396 | 1.226 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.061220 | 1.213 |
| R-HSA-164944 | Nef and signal transduction | 0.061220 | 1.213 |
| R-HSA-68877 | Mitotic Prometaphase | 0.062860 | 1.202 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.083035 | 1.081 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.080789 | 1.093 |
| R-HSA-5652227 | Fructose biosynthesis | 0.074311 | 1.129 |
| R-HSA-9843745 | Adipogenesis | 0.085349 | 1.069 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.080789 | 1.093 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.070101 | 1.154 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.080789 | 1.093 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.080789 | 1.093 |
| R-HSA-448706 | Interleukin-1 processing | 0.080789 | 1.093 |
| R-HSA-68886 | M Phase | 0.065123 | 1.186 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.074868 | 1.126 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.080789 | 1.093 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.071779 | 1.144 |
| R-HSA-156590 | Glutathione conjugation | 0.083035 | 1.081 |
| R-HSA-68875 | Mitotic Prophase | 0.068891 | 1.162 |
| R-HSA-70326 | Glucose metabolism | 0.065321 | 1.185 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.087222 | 1.059 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.087222 | 1.059 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.087222 | 1.059 |
| R-HSA-373755 | Semaphorin interactions | 0.089331 | 1.049 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.093610 | 1.029 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.106253 | 0.974 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.137103 | 0.863 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.161021 | 0.793 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.189996 | 0.721 |
| R-HSA-429947 | Deadenylation of mRNA | 0.189996 | 0.721 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.149145 | 0.826 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.172732 | 0.763 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.250296 | 0.602 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.257746 | 0.589 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.257746 | 0.589 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.257746 | 0.589 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.212460 | 0.673 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.250296 | 0.602 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.201306 | 0.696 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.206903 | 0.684 |
| R-HSA-3371568 | Attenuation phase | 0.281289 | 0.551 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.196008 | 0.708 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.196008 | 0.708 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.173365 | 0.761 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.172732 | 0.763 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.217979 | 0.662 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.099954 | 1.000 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.112510 | 0.949 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.124892 | 0.903 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.172732 | 0.763 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.189996 | 0.721 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.260772 | 0.584 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.281289 | 0.551 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.155104 | 0.809 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.104539 | 0.981 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.239674 | 0.620 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.159404 | 0.798 |
| R-HSA-525793 | Myogenesis | 0.201306 | 0.696 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.281289 | 0.551 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.281289 | 0.551 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.166897 | 0.778 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.136786 | 0.864 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.195671 | 0.708 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.195671 | 0.708 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.189996 | 0.721 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.189996 | 0.721 |
| R-HSA-5689603 | UCH proteinases | 0.118089 | 0.928 |
| R-HSA-167172 | Transcription of the HIV genome | 0.100124 | 0.999 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.112510 | 0.949 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.206903 | 0.684 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.136719 | 0.864 |
| R-HSA-68882 | Mitotic Anaphase | 0.230560 | 0.637 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.232408 | 0.634 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.106253 | 0.974 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.131019 | 0.883 |
| R-HSA-9664420 | Killing mechanisms | 0.131019 | 0.883 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.118722 | 0.925 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.124892 | 0.903 |
| R-HSA-9930044 | Nuclear RNA decay | 0.239674 | 0.620 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.245004 | 0.611 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.206903 | 0.684 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.149145 | 0.826 |
| R-HSA-182971 | EGFR downregulation | 0.228902 | 0.640 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.113524 | 0.945 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.118722 | 0.925 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.137103 | 0.863 |
| R-HSA-70370 | Galactose catabolism | 0.137103 | 0.863 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.184281 | 0.735 |
| R-HSA-9609690 | HCMV Early Events | 0.192508 | 0.716 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.149688 | 0.825 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.124892 | 0.903 |
| R-HSA-392517 | Rap1 signalling | 0.155104 | 0.809 |
| R-HSA-5652084 | Fructose metabolism | 0.178527 | 0.748 |
| R-HSA-3371511 | HSF1 activation | 0.260772 | 0.584 |
| R-HSA-5260271 | Diseases of Immune System | 0.281289 | 0.551 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.281289 | 0.551 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.122628 | 0.911 |
| R-HSA-8953854 | Metabolism of RNA | 0.253137 | 0.597 |
| R-HSA-193144 | Estrogen biosynthesis | 0.106253 | 0.974 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.161021 | 0.793 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.178527 | 0.748 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.205015 | 0.688 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.154652 | 0.811 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.245004 | 0.611 |
| R-HSA-9610379 | HCMV Late Events | 0.125711 | 0.901 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.146367 | 0.835 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.185893 | 0.731 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.136786 | 0.864 |
| R-HSA-445144 | Signal transduction by L1 | 0.161021 | 0.793 |
| R-HSA-189483 | Heme degradation | 0.245004 | 0.611 |
| R-HSA-168255 | Influenza Infection | 0.163038 | 0.788 |
| R-HSA-1181150 | Signaling by NODAL | 0.161021 | 0.793 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.178527 | 0.748 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.119577 | 0.922 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.198547 | 0.702 |
| R-HSA-1640170 | Cell Cycle | 0.251788 | 0.599 |
| R-HSA-9833110 | RSV-host interactions | 0.196008 | 0.708 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.116809 | 0.933 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.162067 | 0.790 |
| R-HSA-9658195 | Leishmania infection | 0.162067 | 0.790 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.239674 | 0.620 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.255552 | 0.593 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.122700 | 0.911 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.193472 | 0.713 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.111259 | 0.954 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.188415 | 0.725 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.155104 | 0.809 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.184281 | 0.735 |
| R-HSA-2262752 | Cellular responses to stress | 0.193842 | 0.713 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.184281 | 0.735 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.097937 | 1.009 |
| R-HSA-1474165 | Reproduction | 0.273303 | 0.563 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.255552 | 0.593 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.103309 | 0.986 |
| R-HSA-354192 | Integrin signaling | 0.239674 | 0.620 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.143958 | 0.842 |
| R-HSA-622312 | Inflammasomes | 0.212460 | 0.673 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.245004 | 0.611 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.244794 | 0.611 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.145061 | 0.838 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.252906 | 0.597 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.234307 | 0.630 |
| R-HSA-195721 | Signaling by WNT | 0.185339 | 0.732 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.158502 | 0.800 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.130388 | 0.885 |
| R-HSA-72306 | tRNA processing | 0.148046 | 0.830 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.203639 | 0.691 |
| R-HSA-5619102 | SLC transporter disorders | 0.141535 | 0.849 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.203639 | 0.691 |
| R-HSA-9824446 | Viral Infection Pathways | 0.285834 | 0.544 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.286330 | 0.543 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.286330 | 0.543 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.286330 | 0.543 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.286330 | 0.543 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.288872 | 0.539 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.291336 | 0.536 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.291336 | 0.536 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.294026 | 0.532 |
| R-HSA-9609646 | HCMV Infection | 0.294595 | 0.531 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.296306 | 0.528 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.296306 | 0.528 |
| R-HSA-165159 | MTOR signalling | 0.296306 | 0.528 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.301781 | 0.520 |
| R-HSA-9664407 | Parasite infection | 0.301781 | 0.520 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.301781 | 0.520 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.302196 | 0.520 |
| R-HSA-5688426 | Deubiquitination | 0.304150 | 0.517 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.304363 | 0.517 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.306063 | 0.514 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.306144 | 0.514 |
| R-HSA-2172127 | DAP12 interactions | 0.306144 | 0.514 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.309890 | 0.509 |
| R-HSA-774815 | Nucleosome assembly | 0.311012 | 0.507 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.311012 | 0.507 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.311012 | 0.507 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.311012 | 0.507 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.311012 | 0.507 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.312098 | 0.506 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.314673 | 0.502 |
| R-HSA-913531 | Interferon Signaling | 0.315375 | 0.501 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.315846 | 0.501 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.315846 | 0.501 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.315846 | 0.501 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.315846 | 0.501 |
| R-HSA-75153 | Apoptotic execution phase | 0.315846 | 0.501 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.320646 | 0.494 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.325413 | 0.488 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.332634 | 0.478 |
| R-HSA-1280218 | Adaptive Immune System | 0.333806 | 0.477 |
| R-HSA-9748787 | Azathioprine ADME | 0.334848 | 0.475 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.339516 | 0.469 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.339516 | 0.469 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.339516 | 0.469 |
| R-HSA-9864848 | Complex IV assembly | 0.339516 | 0.469 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.340293 | 0.468 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.344152 | 0.463 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.348755 | 0.457 |
| R-HSA-72649 | Translation initiation complex formation | 0.353327 | 0.452 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.357866 | 0.446 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.362374 | 0.441 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.362374 | 0.441 |
| R-HSA-75893 | TNF signaling | 0.362374 | 0.441 |
| R-HSA-177929 | Signaling by EGFR | 0.362374 | 0.441 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.362374 | 0.441 |
| R-HSA-422475 | Axon guidance | 0.365535 | 0.437 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.371296 | 0.430 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.375711 | 0.425 |
| R-HSA-9679506 | SARS-CoV Infections | 0.379493 | 0.421 |
| R-HSA-983189 | Kinesins | 0.380095 | 0.420 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.380095 | 0.420 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.384448 | 0.415 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.393064 | 0.406 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.393064 | 0.406 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.393064 | 0.406 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.395519 | 0.403 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.397327 | 0.401 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.397327 | 0.401 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.401560 | 0.396 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.401560 | 0.396 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.405764 | 0.392 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.405764 | 0.392 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.414084 | 0.383 |
| R-HSA-9675108 | Nervous system development | 0.417125 | 0.380 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.422289 | 0.374 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.422289 | 0.374 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.422289 | 0.374 |
| R-HSA-69275 | G2/M Transition | 0.422360 | 0.374 |
| R-HSA-74160 | Gene expression (Transcription) | 0.425388 | 0.371 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.426348 | 0.370 |
| R-HSA-189445 | Metabolism of porphyrins | 0.426348 | 0.370 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.426348 | 0.370 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.427176 | 0.369 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.429652 | 0.367 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.430380 | 0.366 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.430380 | 0.366 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.434383 | 0.362 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.436746 | 0.360 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.438358 | 0.358 |
| R-HSA-380287 | Centrosome maturation | 0.442306 | 0.354 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.442306 | 0.354 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.445287 | 0.351 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.446226 | 0.350 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.453984 | 0.343 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.461635 | 0.336 |
| R-HSA-9833482 | PKR-mediated signaling | 0.461635 | 0.336 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.465420 | 0.332 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.469179 | 0.329 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.472912 | 0.325 |
| R-HSA-168249 | Innate Immune System | 0.477389 | 0.321 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.480300 | 0.318 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.480623 | 0.318 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.483955 | 0.315 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.485529 | 0.314 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.487585 | 0.312 |
| R-HSA-70268 | Pyruvate metabolism | 0.491189 | 0.309 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.494769 | 0.306 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.494769 | 0.306 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.501853 | 0.299 |
| R-HSA-202424 | Downstream TCR signaling | 0.501853 | 0.299 |
| R-HSA-73884 | Base Excision Repair | 0.501853 | 0.299 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.505607 | 0.296 |
| R-HSA-199991 | Membrane Trafficking | 0.507119 | 0.295 |
| R-HSA-2029481 | FCGR activation | 0.515727 | 0.288 |
| R-HSA-1266738 | Developmental Biology | 0.520995 | 0.283 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.521222 | 0.283 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.522519 | 0.282 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.529218 | 0.276 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.529218 | 0.276 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.529218 | 0.276 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.532532 | 0.274 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.535823 | 0.271 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.535823 | 0.271 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.535823 | 0.271 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.539091 | 0.268 |
| R-HSA-3214847 | HATs acetylate histones | 0.539091 | 0.268 |
| R-HSA-8939211 | ESR-mediated signaling | 0.540110 | 0.268 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.544303 | 0.264 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.545559 | 0.263 |
| R-HSA-5663205 | Infectious disease | 0.546527 | 0.262 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.555092 | 0.256 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.561337 | 0.251 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.564427 | 0.248 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.570542 | 0.244 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.570542 | 0.244 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.570542 | 0.244 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.570542 | 0.244 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.570542 | 0.244 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.573568 | 0.241 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.576573 | 0.239 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.576573 | 0.239 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.582519 | 0.235 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.585461 | 0.233 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.588382 | 0.230 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.594164 | 0.226 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.594164 | 0.226 |
| R-HSA-168256 | Immune System | 0.597761 | 0.223 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.599866 | 0.222 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.599866 | 0.222 |
| R-HSA-373760 | L1CAM interactions | 0.599866 | 0.222 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.602686 | 0.220 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.605487 | 0.218 |
| R-HSA-5693538 | Homology Directed Repair | 0.605487 | 0.218 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.608269 | 0.216 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.608269 | 0.216 |
| R-HSA-73886 | Chromosome Maintenance | 0.613774 | 0.212 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.616498 | 0.210 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.616498 | 0.210 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.619202 | 0.208 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.629833 | 0.201 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.635037 | 0.197 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.647733 | 0.189 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.650868 | 0.187 |
| R-HSA-6798695 | Neutrophil degranulation | 0.655369 | 0.184 |
| R-HSA-6807070 | PTEN Regulation | 0.667142 | 0.176 |
| R-HSA-449147 | Signaling by Interleukins | 0.668514 | 0.175 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.687713 | 0.163 |
| R-HSA-2187338 | Visual phototransduction | 0.687713 | 0.163 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.689919 | 0.161 |
| R-HSA-166520 | Signaling by NTRKs | 0.689919 | 0.161 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.694285 | 0.158 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.694285 | 0.158 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.696348 | 0.157 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.696579 | 0.157 |
| R-HSA-8957322 | Metabolism of steroids | 0.697879 | 0.156 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.698591 | 0.156 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.700721 | 0.154 |
| R-HSA-1989781 | PPARA activates gene expression | 0.704937 | 0.152 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.709094 | 0.149 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.711150 | 0.148 |
| R-HSA-109581 | Apoptosis | 0.719233 | 0.143 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.722949 | 0.141 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.724368 | 0.140 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.736610 | 0.133 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.740324 | 0.131 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.742162 | 0.130 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.742162 | 0.130 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.742162 | 0.130 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.742162 | 0.130 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.742162 | 0.130 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.745799 | 0.127 |
| R-HSA-73894 | DNA Repair | 0.748891 | 0.126 |
| R-HSA-611105 | Respiratory electron transport | 0.751158 | 0.124 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.752792 | 0.123 |
| R-HSA-2559583 | Cellular Senescence | 0.754669 | 0.122 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.768229 | 0.115 |
| R-HSA-983712 | Ion channel transport | 0.769870 | 0.114 |
| R-HSA-5617833 | Cilium Assembly | 0.771501 | 0.113 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.773119 | 0.112 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.777908 | 0.109 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.778682 | 0.109 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.781045 | 0.107 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.787187 | 0.104 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.787187 | 0.104 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.790193 | 0.102 |
| R-HSA-72172 | mRNA Splicing | 0.794625 | 0.100 |
| R-HSA-5357801 | Programmed Cell Death | 0.796081 | 0.099 |
| R-HSA-1643685 | Disease | 0.805854 | 0.094 |
| R-HSA-397014 | Muscle contraction | 0.805993 | 0.094 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.807369 | 0.093 |
| R-HSA-9748784 | Drug ADME | 0.814108 | 0.089 |
| R-HSA-418990 | Adherens junctions interactions | 0.814108 | 0.089 |
| R-HSA-388396 | GPCR downstream signalling | 0.814160 | 0.089 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.824407 | 0.084 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.828121 | 0.082 |
| R-HSA-72312 | rRNA processing | 0.831758 | 0.080 |
| R-HSA-421270 | Cell-cell junction organization | 0.853082 | 0.069 |
| R-HSA-112316 | Neuronal System | 0.860816 | 0.065 |
| R-HSA-416476 | G alpha (q) signalling events | 0.866106 | 0.062 |
| R-HSA-372790 | Signaling by GPCR | 0.869808 | 0.061 |
| R-HSA-212436 | Generic Transcription Pathway | 0.872230 | 0.059 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.875339 | 0.058 |
| R-HSA-446728 | Cell junction organization | 0.878853 | 0.056 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.882269 | 0.054 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.888019 | 0.052 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.893491 | 0.049 |
| R-HSA-211859 | Biological oxidations | 0.898107 | 0.047 |
| R-HSA-1500931 | Cell-Cell communication | 0.907705 | 0.042 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.910314 | 0.041 |
| R-HSA-597592 | Post-translational protein modification | 0.913028 | 0.040 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.923744 | 0.034 |
| R-HSA-109582 | Hemostasis | 0.925552 | 0.034 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.934605 | 0.029 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.957244 | 0.019 |
| R-HSA-72766 | Translation | 0.959350 | 0.018 |
| R-HSA-392499 | Metabolism of proteins | 0.992140 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.998808 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999297 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999898 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999947 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.850 | 0.692 | 1 | 0.875 |
CDK18 |
0.845 | 0.740 | 1 | 0.914 |
CDK19 |
0.844 | 0.721 | 1 | 0.918 |
HIPK2 |
0.841 | 0.688 | 1 | 0.884 |
CDK8 |
0.839 | 0.712 | 1 | 0.903 |
CDK1 |
0.838 | 0.713 | 1 | 0.908 |
CDK3 |
0.838 | 0.661 | 1 | 0.919 |
CDK17 |
0.837 | 0.733 | 1 | 0.917 |
CDK5 |
0.837 | 0.706 | 1 | 0.891 |
CLK3 |
0.837 | 0.508 | 1 | 0.727 |
CDK7 |
0.837 | 0.700 | 1 | 0.903 |
JNK2 |
0.834 | 0.747 | 1 | 0.908 |
P38G |
0.833 | 0.734 | 1 | 0.919 |
CDK10 |
0.831 | 0.675 | 1 | 0.906 |
CDK16 |
0.830 | 0.710 | 1 | 0.909 |
CDK13 |
0.830 | 0.694 | 1 | 0.901 |
P38B |
0.829 | 0.730 | 1 | 0.883 |
DYRK2 |
0.828 | 0.658 | 1 | 0.849 |
ERK1 |
0.828 | 0.707 | 1 | 0.893 |
CDK14 |
0.828 | 0.706 | 1 | 0.900 |
P38D |
0.827 | 0.729 | 1 | 0.913 |
DYRK4 |
0.826 | 0.670 | 1 | 0.901 |
CDK12 |
0.826 | 0.691 | 1 | 0.903 |
HIPK4 |
0.825 | 0.484 | 1 | 0.711 |
HIPK1 |
0.824 | 0.619 | 1 | 0.848 |
P38A |
0.824 | 0.705 | 1 | 0.863 |
CDK9 |
0.822 | 0.677 | 1 | 0.898 |
JNK3 |
0.822 | 0.720 | 1 | 0.893 |
NLK |
0.820 | 0.622 | 1 | 0.745 |
SRPK1 |
0.819 | 0.334 | -3 | 0.754 |
DYRK1B |
0.814 | 0.620 | 1 | 0.885 |
CLK2 |
0.812 | 0.399 | -3 | 0.758 |
ERK2 |
0.812 | 0.673 | 1 | 0.867 |
HIPK3 |
0.811 | 0.589 | 1 | 0.810 |
CDK6 |
0.811 | 0.662 | 1 | 0.903 |
ERK5 |
0.810 | 0.356 | 1 | 0.667 |
DYRK1A |
0.809 | 0.529 | 1 | 0.836 |
MAK |
0.808 | 0.507 | -2 | 0.825 |
CLK1 |
0.808 | 0.378 | -3 | 0.756 |
CDK4 |
0.808 | 0.671 | 1 | 0.907 |
CDK2 |
0.808 | 0.529 | 1 | 0.846 |
MTOR |
0.807 | 0.254 | 1 | 0.549 |
CLK4 |
0.806 | 0.351 | -3 | 0.775 |
ICK |
0.806 | 0.366 | -3 | 0.846 |
JNK1 |
0.805 | 0.644 | 1 | 0.907 |
SRPK2 |
0.805 | 0.258 | -3 | 0.684 |
CDKL5 |
0.802 | 0.187 | -3 | 0.799 |
COT |
0.800 | -0.017 | 2 | 0.790 |
DYRK3 |
0.800 | 0.467 | 1 | 0.814 |
CDKL1 |
0.799 | 0.168 | -3 | 0.806 |
MOS |
0.797 | 0.061 | 1 | 0.490 |
NDR2 |
0.796 | 0.055 | -3 | 0.872 |
SRPK3 |
0.794 | 0.224 | -3 | 0.727 |
PRKD1 |
0.794 | 0.081 | -3 | 0.847 |
CDC7 |
0.792 | -0.067 | 1 | 0.443 |
PIM3 |
0.792 | 0.018 | -3 | 0.854 |
MST4 |
0.792 | 0.034 | 2 | 0.781 |
PRPK |
0.791 | -0.050 | -1 | 0.768 |
RSK2 |
0.790 | 0.051 | -3 | 0.787 |
PRKD2 |
0.790 | 0.072 | -3 | 0.796 |
MOK |
0.789 | 0.429 | 1 | 0.755 |
SKMLCK |
0.787 | 0.025 | -2 | 0.857 |
AURC |
0.786 | 0.062 | -2 | 0.690 |
NDR1 |
0.785 | -0.007 | -3 | 0.855 |
CAMK1B |
0.785 | -0.010 | -3 | 0.861 |
WNK1 |
0.785 | -0.043 | -2 | 0.883 |
PRP4 |
0.785 | 0.375 | -3 | 0.719 |
GRK1 |
0.784 | 0.037 | -2 | 0.767 |
P90RSK |
0.784 | 0.032 | -3 | 0.781 |
PIM1 |
0.784 | 0.057 | -3 | 0.801 |
ATR |
0.783 | -0.035 | 1 | 0.441 |
PKN3 |
0.782 | -0.026 | -3 | 0.838 |
RSK3 |
0.781 | 0.011 | -3 | 0.776 |
PKN2 |
0.781 | -0.024 | -3 | 0.850 |
MPSK1 |
0.781 | 0.184 | 1 | 0.495 |
PKCD |
0.781 | 0.025 | 2 | 0.700 |
CHAK2 |
0.781 | -0.034 | -1 | 0.751 |
PDHK4 |
0.781 | -0.150 | 1 | 0.478 |
IKKB |
0.780 | -0.148 | -2 | 0.702 |
TBK1 |
0.780 | -0.157 | 1 | 0.362 |
PKACG |
0.780 | 0.020 | -2 | 0.772 |
CAMLCK |
0.780 | 0.005 | -2 | 0.836 |
BMPR2 |
0.780 | -0.155 | -2 | 0.825 |
RAF1 |
0.779 | -0.193 | 1 | 0.426 |
CAMK2D |
0.779 | -0.012 | -3 | 0.852 |
NIK |
0.779 | -0.038 | -3 | 0.881 |
NUAK2 |
0.778 | -0.011 | -3 | 0.857 |
CAMK2G |
0.778 | -0.082 | 2 | 0.771 |
GCN2 |
0.777 | -0.211 | 2 | 0.698 |
MAPKAPK2 |
0.777 | 0.015 | -3 | 0.759 |
MAPKAPK3 |
0.777 | -0.018 | -3 | 0.798 |
DAPK2 |
0.776 | -0.021 | -3 | 0.870 |
IKKE |
0.776 | -0.168 | 1 | 0.359 |
DSTYK |
0.776 | -0.150 | 2 | 0.816 |
LATS2 |
0.775 | -0.018 | -5 | 0.753 |
TGFBR2 |
0.775 | -0.098 | -2 | 0.719 |
PKCA |
0.775 | 0.034 | 2 | 0.642 |
PKACB |
0.775 | 0.063 | -2 | 0.705 |
PKG2 |
0.774 | 0.047 | -2 | 0.726 |
P70S6KB |
0.774 | -0.004 | -3 | 0.806 |
LATS1 |
0.774 | 0.082 | -3 | 0.883 |
MNK2 |
0.774 | 0.003 | -2 | 0.793 |
PKCB |
0.774 | 0.011 | 2 | 0.650 |
RSK4 |
0.774 | 0.040 | -3 | 0.770 |
FAM20C |
0.774 | 0.155 | 2 | 0.777 |
ULK2 |
0.773 | -0.220 | 2 | 0.689 |
RIPK3 |
0.773 | -0.154 | 3 | 0.639 |
GRK5 |
0.773 | -0.130 | -3 | 0.856 |
PKCG |
0.773 | 0.006 | 2 | 0.659 |
ERK7 |
0.772 | 0.201 | 2 | 0.455 |
IRE1 |
0.772 | -0.089 | 1 | 0.410 |
AKT2 |
0.772 | 0.056 | -3 | 0.704 |
PAK6 |
0.772 | 0.022 | -2 | 0.707 |
PRKD3 |
0.772 | 0.020 | -3 | 0.758 |
PRKX |
0.771 | 0.078 | -3 | 0.716 |
PDHK1 |
0.771 | -0.217 | 1 | 0.454 |
NEK6 |
0.771 | -0.118 | -2 | 0.774 |
MLK1 |
0.771 | -0.153 | 2 | 0.729 |
MNK1 |
0.771 | 0.018 | -2 | 0.802 |
CAMK2A |
0.770 | 0.015 | 2 | 0.759 |
IKKA |
0.770 | -0.089 | -2 | 0.685 |
AMPKA1 |
0.770 | -0.078 | -3 | 0.870 |
GSK3A |
0.769 | 0.193 | 4 | 0.466 |
MLK3 |
0.769 | -0.035 | 2 | 0.668 |
MLK2 |
0.769 | -0.091 | 2 | 0.726 |
GRK7 |
0.769 | 0.021 | 1 | 0.420 |
BMPR1B |
0.768 | -0.018 | 1 | 0.432 |
MASTL |
0.768 | -0.172 | -2 | 0.766 |
PAK1 |
0.767 | -0.038 | -2 | 0.798 |
CAMK2B |
0.767 | -0.004 | 2 | 0.769 |
BCKDK |
0.767 | -0.164 | -1 | 0.684 |
MARK4 |
0.766 | -0.096 | 4 | 0.714 |
PIM2 |
0.766 | 0.041 | -3 | 0.759 |
PAK3 |
0.766 | -0.063 | -2 | 0.789 |
AMPKA2 |
0.766 | -0.055 | -3 | 0.844 |
PHKG1 |
0.766 | -0.064 | -3 | 0.846 |
AURB |
0.766 | -0.001 | -2 | 0.677 |
VRK2 |
0.765 | 0.026 | 1 | 0.521 |
TGFBR1 |
0.765 | -0.035 | -2 | 0.745 |
NIM1 |
0.765 | -0.081 | 3 | 0.679 |
RIPK1 |
0.765 | -0.198 | 1 | 0.398 |
PKR |
0.765 | -0.076 | 1 | 0.449 |
SGK3 |
0.764 | 0.014 | -3 | 0.783 |
WNK3 |
0.764 | -0.256 | 1 | 0.413 |
PKCZ |
0.764 | -0.043 | 2 | 0.677 |
GRK6 |
0.764 | -0.135 | 1 | 0.431 |
DLK |
0.764 | -0.195 | 1 | 0.442 |
TSSK1 |
0.763 | -0.057 | -3 | 0.888 |
NEK7 |
0.763 | -0.253 | -3 | 0.842 |
PKCH |
0.763 | -0.042 | 2 | 0.633 |
ALK4 |
0.763 | -0.071 | -2 | 0.774 |
TSSK2 |
0.763 | -0.088 | -5 | 0.825 |
MSK1 |
0.763 | -0.003 | -3 | 0.761 |
MST3 |
0.762 | 0.014 | 2 | 0.748 |
IRE2 |
0.762 | -0.090 | 2 | 0.654 |
BUB1 |
0.762 | 0.150 | -5 | 0.825 |
CAMK4 |
0.762 | -0.108 | -3 | 0.842 |
MSK2 |
0.761 | -0.043 | -3 | 0.757 |
ULK1 |
0.761 | -0.228 | -3 | 0.797 |
DNAPK |
0.761 | -0.021 | 1 | 0.353 |
MYLK4 |
0.760 | -0.034 | -2 | 0.776 |
HUNK |
0.759 | -0.249 | 2 | 0.725 |
NEK9 |
0.759 | -0.235 | 2 | 0.730 |
MEK1 |
0.759 | -0.137 | 2 | 0.758 |
SMG1 |
0.759 | -0.077 | 1 | 0.404 |
PINK1 |
0.758 | 0.078 | 1 | 0.609 |
CK1E |
0.758 | 0.016 | -3 | 0.594 |
PKCE |
0.758 | 0.034 | 2 | 0.645 |
MELK |
0.758 | -0.097 | -3 | 0.823 |
AKT1 |
0.758 | 0.026 | -3 | 0.730 |
PKACA |
0.758 | 0.036 | -2 | 0.669 |
GSK3B |
0.758 | 0.063 | 4 | 0.462 |
ANKRD3 |
0.758 | -0.236 | 1 | 0.443 |
GRK4 |
0.757 | -0.173 | -2 | 0.766 |
PASK |
0.756 | 0.020 | -3 | 0.880 |
AURA |
0.755 | -0.023 | -2 | 0.629 |
TTBK2 |
0.755 | -0.220 | 2 | 0.625 |
CHAK1 |
0.755 | -0.165 | 2 | 0.683 |
YSK4 |
0.755 | -0.166 | 1 | 0.391 |
DCAMKL1 |
0.755 | -0.034 | -3 | 0.810 |
PAK2 |
0.755 | -0.088 | -2 | 0.774 |
MLK4 |
0.754 | -0.121 | 2 | 0.641 |
NUAK1 |
0.754 | -0.087 | -3 | 0.806 |
QSK |
0.754 | -0.078 | 4 | 0.694 |
QIK |
0.753 | -0.143 | -3 | 0.850 |
ATM |
0.753 | -0.115 | 1 | 0.374 |
GAK |
0.753 | 0.034 | 1 | 0.517 |
ACVR2B |
0.753 | -0.099 | -2 | 0.721 |
PKCI |
0.753 | -0.028 | 2 | 0.651 |
PKCT |
0.753 | -0.040 | 2 | 0.638 |
NEK2 |
0.753 | -0.165 | 2 | 0.706 |
TAO3 |
0.752 | -0.014 | 1 | 0.440 |
CK1D |
0.752 | 0.041 | -3 | 0.545 |
ALK2 |
0.752 | -0.080 | -2 | 0.749 |
AKT3 |
0.752 | 0.049 | -3 | 0.647 |
ACVR2A |
0.752 | -0.107 | -2 | 0.706 |
CHK1 |
0.750 | -0.066 | -3 | 0.853 |
IRAK4 |
0.750 | -0.133 | 1 | 0.389 |
MAPKAPK5 |
0.749 | -0.099 | -3 | 0.730 |
DRAK1 |
0.749 | -0.142 | 1 | 0.388 |
MEK5 |
0.749 | -0.174 | 2 | 0.730 |
DCAMKL2 |
0.749 | -0.053 | -3 | 0.824 |
PHKG2 |
0.749 | -0.082 | -3 | 0.814 |
SMMLCK |
0.749 | -0.038 | -3 | 0.823 |
GRK2 |
0.749 | -0.090 | -2 | 0.670 |
WNK4 |
0.748 | -0.151 | -2 | 0.862 |
SIK |
0.747 | -0.088 | -3 | 0.782 |
BMPR1A |
0.747 | -0.063 | 1 | 0.420 |
CK1A2 |
0.747 | 0.013 | -3 | 0.546 |
CAMK1G |
0.747 | -0.084 | -3 | 0.773 |
TLK2 |
0.747 | -0.156 | 1 | 0.389 |
ZAK |
0.747 | -0.161 | 1 | 0.403 |
PLK4 |
0.746 | -0.153 | 2 | 0.567 |
MARK3 |
0.746 | -0.095 | 4 | 0.639 |
GCK |
0.746 | -0.013 | 1 | 0.437 |
BRSK2 |
0.745 | -0.144 | -3 | 0.828 |
LKB1 |
0.745 | -0.020 | -3 | 0.836 |
PLK1 |
0.745 | -0.220 | -2 | 0.707 |
PBK |
0.745 | 0.042 | 1 | 0.483 |
P70S6K |
0.745 | -0.046 | -3 | 0.721 |
PAK5 |
0.745 | -0.038 | -2 | 0.638 |
TNIK |
0.745 | 0.017 | 3 | 0.829 |
PERK |
0.744 | -0.190 | -2 | 0.763 |
MEKK2 |
0.744 | -0.146 | 2 | 0.703 |
BRSK1 |
0.744 | -0.121 | -3 | 0.807 |
SSTK |
0.744 | -0.073 | 4 | 0.687 |
HPK1 |
0.744 | -0.017 | 1 | 0.418 |
TAO2 |
0.744 | -0.052 | 2 | 0.758 |
SGK1 |
0.743 | 0.044 | -3 | 0.629 |
MEKK3 |
0.743 | -0.199 | 1 | 0.424 |
MEKK1 |
0.743 | -0.201 | 1 | 0.425 |
HGK |
0.743 | -0.027 | 3 | 0.823 |
SBK |
0.743 | 0.108 | -3 | 0.590 |
CK1G1 |
0.743 | -0.037 | -3 | 0.567 |
PAK4 |
0.743 | -0.027 | -2 | 0.640 |
SNRK |
0.743 | -0.209 | 2 | 0.592 |
NEK11 |
0.742 | -0.136 | 1 | 0.423 |
HRI |
0.742 | -0.223 | -2 | 0.774 |
MAP3K15 |
0.742 | -0.046 | 1 | 0.400 |
BRAF |
0.742 | -0.163 | -4 | 0.773 |
PKN1 |
0.741 | -0.041 | -3 | 0.740 |
KHS2 |
0.741 | 0.030 | 1 | 0.425 |
NEK5 |
0.741 | -0.180 | 1 | 0.418 |
MRCKB |
0.741 | 0.013 | -3 | 0.753 |
MEKK6 |
0.741 | -0.076 | 1 | 0.422 |
KHS1 |
0.741 | 0.010 | 1 | 0.403 |
MARK2 |
0.740 | -0.123 | 4 | 0.595 |
HASPIN |
0.740 | 0.030 | -1 | 0.620 |
MINK |
0.740 | -0.068 | 1 | 0.405 |
ROCK2 |
0.740 | 0.022 | -3 | 0.807 |
PDK1 |
0.739 | -0.076 | 1 | 0.418 |
DAPK3 |
0.738 | -0.038 | -3 | 0.815 |
MRCKA |
0.738 | -0.001 | -3 | 0.771 |
LOK |
0.737 | -0.047 | -2 | 0.747 |
PLK3 |
0.737 | -0.185 | 2 | 0.715 |
DMPK1 |
0.737 | 0.051 | -3 | 0.778 |
MARK1 |
0.735 | -0.143 | 4 | 0.660 |
CAMK1D |
0.735 | -0.048 | -3 | 0.704 |
TLK1 |
0.735 | -0.204 | -2 | 0.752 |
CK2A2 |
0.735 | -0.060 | 1 | 0.400 |
NEK4 |
0.734 | -0.154 | 1 | 0.394 |
DAPK1 |
0.734 | -0.040 | -3 | 0.796 |
LRRK2 |
0.734 | -0.069 | 2 | 0.747 |
GRK3 |
0.734 | -0.092 | -2 | 0.627 |
EEF2K |
0.733 | -0.080 | 3 | 0.770 |
CHK2 |
0.733 | -0.030 | -3 | 0.654 |
CAMKK2 |
0.732 | -0.139 | -2 | 0.723 |
TTBK1 |
0.732 | -0.193 | 2 | 0.559 |
CAMKK1 |
0.732 | -0.205 | -2 | 0.716 |
SLK |
0.732 | -0.062 | -2 | 0.684 |
NEK1 |
0.731 | -0.130 | 1 | 0.393 |
IRAK1 |
0.731 | -0.257 | -1 | 0.652 |
BIKE |
0.730 | 0.031 | 1 | 0.477 |
NEK8 |
0.729 | -0.227 | 2 | 0.717 |
MST2 |
0.729 | -0.152 | 1 | 0.417 |
AAK1 |
0.729 | 0.081 | 1 | 0.452 |
PDHK3_TYR |
0.729 | 0.213 | 4 | 0.830 |
TAK1 |
0.728 | -0.172 | 1 | 0.409 |
CK2A1 |
0.728 | -0.058 | 1 | 0.387 |
YSK1 |
0.728 | -0.095 | 2 | 0.706 |
PKG1 |
0.728 | -0.015 | -2 | 0.662 |
CRIK |
0.727 | 0.023 | -3 | 0.730 |
VRK1 |
0.726 | -0.193 | 2 | 0.750 |
CAMK1A |
0.725 | -0.041 | -3 | 0.674 |
STK33 |
0.725 | -0.149 | 2 | 0.547 |
MST1 |
0.725 | -0.137 | 1 | 0.403 |
LIMK2_TYR |
0.724 | 0.178 | -3 | 0.893 |
TESK1_TYR |
0.722 | 0.115 | 3 | 0.805 |
ROCK1 |
0.721 | -0.014 | -3 | 0.769 |
PKMYT1_TYR |
0.721 | 0.153 | 3 | 0.769 |
MEK2 |
0.718 | -0.229 | 2 | 0.719 |
PDHK4_TYR |
0.718 | 0.096 | 2 | 0.798 |
MAP2K4_TYR |
0.718 | 0.079 | -1 | 0.779 |
ASK1 |
0.717 | -0.097 | 1 | 0.390 |
NEK3 |
0.717 | -0.148 | 1 | 0.394 |
MYO3B |
0.717 | -0.058 | 2 | 0.729 |
RIPK2 |
0.716 | -0.268 | 1 | 0.364 |
OSR1 |
0.716 | -0.090 | 2 | 0.692 |
MAP2K6_TYR |
0.715 | 0.054 | -1 | 0.779 |
TAO1 |
0.715 | -0.082 | 1 | 0.375 |
PLK2 |
0.714 | -0.113 | -3 | 0.767 |
MYO3A |
0.714 | -0.075 | 1 | 0.407 |
BMPR2_TYR |
0.713 | 0.037 | -1 | 0.783 |
CK1A |
0.713 | -0.013 | -3 | 0.453 |
MAP2K7_TYR |
0.712 | -0.072 | 2 | 0.781 |
PDHK1_TYR |
0.711 | -0.019 | -1 | 0.794 |
YANK3 |
0.711 | -0.061 | 2 | 0.373 |
LIMK1_TYR |
0.708 | -0.017 | 2 | 0.769 |
PINK1_TYR |
0.707 | -0.144 | 1 | 0.467 |
TTK |
0.706 | -0.152 | -2 | 0.733 |
EPHA6 |
0.706 | -0.056 | -1 | 0.751 |
RET |
0.703 | -0.124 | 1 | 0.414 |
EPHB4 |
0.702 | -0.089 | -1 | 0.719 |
TXK |
0.701 | -0.038 | 1 | 0.455 |
TYRO3 |
0.701 | -0.133 | 3 | 0.742 |
MST1R |
0.701 | -0.116 | 3 | 0.738 |
JAK2 |
0.701 | -0.102 | 1 | 0.416 |
LCK |
0.700 | -0.039 | -1 | 0.774 |
ABL2 |
0.700 | -0.051 | -1 | 0.706 |
YES1 |
0.700 | -0.076 | -1 | 0.795 |
ALPHAK3 |
0.700 | -0.113 | -1 | 0.658 |
ROS1 |
0.699 | -0.138 | 3 | 0.711 |
FGR |
0.699 | -0.111 | 1 | 0.455 |
ABL1 |
0.698 | -0.055 | -1 | 0.704 |
CSF1R |
0.697 | -0.111 | 3 | 0.721 |
TNNI3K_TYR |
0.697 | -0.030 | 1 | 0.455 |
HCK |
0.696 | -0.103 | -1 | 0.766 |
TNK1 |
0.696 | -0.058 | 3 | 0.722 |
TYK2 |
0.695 | -0.226 | 1 | 0.398 |
DDR1 |
0.695 | -0.150 | 4 | 0.752 |
BLK |
0.694 | -0.062 | -1 | 0.779 |
TNK2 |
0.694 | -0.106 | 3 | 0.672 |
EPHA4 |
0.693 | -0.074 | 2 | 0.726 |
ITK |
0.693 | -0.112 | -1 | 0.710 |
JAK3 |
0.692 | -0.153 | 1 | 0.400 |
JAK1 |
0.691 | -0.098 | 1 | 0.372 |
FYN |
0.690 | -0.042 | -1 | 0.772 |
BMX |
0.690 | -0.095 | -1 | 0.641 |
TEK |
0.690 | -0.063 | 3 | 0.668 |
FER |
0.690 | -0.191 | 1 | 0.448 |
NEK10_TYR |
0.689 | -0.122 | 1 | 0.335 |
EPHB3 |
0.689 | -0.140 | -1 | 0.702 |
SRMS |
0.688 | -0.151 | 1 | 0.420 |
FGFR2 |
0.688 | -0.098 | 3 | 0.692 |
STLK3 |
0.688 | -0.233 | 1 | 0.374 |
EPHB1 |
0.687 | -0.169 | 1 | 0.414 |
INSRR |
0.687 | -0.172 | 3 | 0.665 |
AXL |
0.687 | -0.158 | 3 | 0.689 |
EPHB2 |
0.687 | -0.136 | -1 | 0.698 |
KIT |
0.686 | -0.148 | 3 | 0.713 |
KDR |
0.686 | -0.126 | 3 | 0.662 |
MERTK |
0.686 | -0.142 | 3 | 0.692 |
MET |
0.686 | -0.111 | 3 | 0.715 |
PDGFRB |
0.685 | -0.219 | 3 | 0.724 |
WEE1_TYR |
0.684 | -0.106 | -1 | 0.639 |
FGFR1 |
0.684 | -0.113 | 3 | 0.671 |
PTK2B |
0.684 | -0.065 | -1 | 0.695 |
DDR2 |
0.684 | -0.052 | 3 | 0.636 |
FLT3 |
0.683 | -0.199 | 3 | 0.734 |
TEC |
0.682 | -0.151 | -1 | 0.649 |
LYN |
0.682 | -0.109 | 3 | 0.636 |
EPHA7 |
0.681 | -0.120 | 2 | 0.715 |
BTK |
0.681 | -0.208 | -1 | 0.677 |
PDGFRA |
0.679 | -0.230 | 3 | 0.732 |
EPHA1 |
0.679 | -0.148 | 3 | 0.695 |
EPHA3 |
0.679 | -0.135 | 2 | 0.695 |
PTK2 |
0.679 | -0.028 | -1 | 0.712 |
SRC |
0.679 | -0.101 | -1 | 0.767 |
ERBB2 |
0.678 | -0.172 | 1 | 0.393 |
CK1G3 |
0.678 | -0.044 | -3 | 0.405 |
YANK2 |
0.677 | -0.080 | 2 | 0.389 |
FGFR3 |
0.677 | -0.118 | 3 | 0.660 |
ALK |
0.676 | -0.199 | 3 | 0.641 |
FRK |
0.676 | -0.163 | -1 | 0.751 |
FLT1 |
0.675 | -0.155 | -1 | 0.706 |
LTK |
0.674 | -0.199 | 3 | 0.649 |
INSR |
0.674 | -0.195 | 3 | 0.655 |
PTK6 |
0.673 | -0.235 | -1 | 0.629 |
EPHA8 |
0.673 | -0.120 | -1 | 0.704 |
MATK |
0.671 | -0.130 | -1 | 0.628 |
NTRK1 |
0.670 | -0.255 | -1 | 0.690 |
EGFR |
0.670 | -0.120 | 1 | 0.336 |
EPHA5 |
0.670 | -0.144 | 2 | 0.714 |
SYK |
0.669 | -0.062 | -1 | 0.679 |
FLT4 |
0.669 | -0.215 | 3 | 0.648 |
NTRK3 |
0.669 | -0.184 | -1 | 0.647 |
NTRK2 |
0.668 | -0.262 | 3 | 0.663 |
CSK |
0.667 | -0.160 | 2 | 0.714 |
CK1G2 |
0.666 | -0.045 | -3 | 0.494 |
FGFR4 |
0.665 | -0.124 | -1 | 0.650 |
ERBB4 |
0.665 | -0.084 | 1 | 0.348 |
EPHA2 |
0.663 | -0.126 | -1 | 0.660 |
MUSK |
0.662 | -0.165 | 1 | 0.314 |
ZAP70 |
0.661 | -0.032 | -1 | 0.615 |
IGF1R |
0.656 | -0.189 | 3 | 0.593 |
FES |
0.649 | -0.172 | -1 | 0.618 |