Motif 237 (n=157)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00512 | BCL9 | S1044 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14613 | CDC42EP2 | S101 | ochoa | Cdc42 effector protein 2 (Binder of Rho GTPases 1) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| O14654 | IRS4 | S735 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S2019 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14827 | RASGRF2 | S718 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O15371 | EIF3D | S308 | ochoa | Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66) | mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O75943 | RAD17 | S416 | ochoa | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O94782 | USP1 | S313 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94855 | SEC24D | S826 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94885 | SASH1 | S297 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| P08151 | GLI1 | S130 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P11308 | ERG | S215 | psp | Transcriptional regulator ERG (Transforming protein ERG) | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| P12259 | F5 | S1150 | ochoa | Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. |
| P20827 | EFNA1 | S154 | ochoa | Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form] | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}. |
| P30307 | CDC25C | S214 | ochoa|psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P38936 | CDKN1A | S98 | ochoa|psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P46531 | NOTCH1 | S2121 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P49137 | MAPKAPK2 | S272 | psp | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
| P51587 | BRCA2 | S93 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51787 | KCNQ1 | S468 | ochoa|psp | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P52735 | VAV2 | S639 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P55196 | AFDN | S1107 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56945 | BCAR1 | S260 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P57682 | KLF3 | S92 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P57739 | CLDN2 | S192 | ochoa | Claudin-2 (SP82) | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:20460438, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (By similarity). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (By similarity). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (By similarity). {ECO:0000250|UniProtKB:O88552, ECO:0000269|PubMed:20460438, ECO:0000269|PubMed:36008380}. |
| Q01196 | RUNX1 | S435 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q01484 | ANK2 | S2440 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02078 | MEF2A | S235 | ochoa | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03111 | MLLT1 | S155 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q04721 | NOTCH2 | S2081 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q09666 | AHNAK | S5110 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13029 | PRDM2 | S912 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q13085 | ACACA | S2327 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13112 | CHAF1B | S410 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13523 | PRP4K | S241 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14139 | UBE4A | S940 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
| Q14159 | SPIDR | S826 | ochoa | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:27967308, ECO:0000269|PubMed:34697795}. |
| Q14204 | DYNC1H1 | S3082 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14699 | RFTN1 | S220 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q14814 | MEF2D | S231 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14938 | NFIX | S268 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15003 | NCAPH | S432 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15181 | PPA1 | S250 | ochoa | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| Q15434 | RBMS2 | S285 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q16204 | CCDC6 | S395 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16625 | OCLN | S321 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q16644 | MAPKAPK3 | S251 | psp | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550, ECO:0000269|PubMed:8774846}. |
| Q2V2M9 | FHOD3 | S763 | ochoa | FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) | Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269|PubMed:21149568}. |
| Q49AM3 | TTC31 | S278 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q562E7 | WDR81 | S686 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q562E7 | WDR81 | S1272 | ochoa | WD repeat-containing protein 81 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). {ECO:0000250|UniProtKB:Q5ND34, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. |
| Q5JXC2 | MIIP | S307 | ochoa | Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}. |
| Q5M775 | SPECC1 | S935 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T3J3 | LRIF1 | S386 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5TCX8 | MAP3K21 | S528 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5TCZ1 | SH3PXD2A | S1043 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TGY3 | AHDC1 | S1507 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TZA2 | CROCC | S494 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VUA4 | ZNF318 | S1420 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUA4 | ZNF318 | S2243 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWJ9 | SNX30 | S40 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
| Q5VZ89 | DENND4C | S1104 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63HK5 | TSHZ3 | S584 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q6DN90 | IQSEC1 | S211 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6IC98 | GRAMD4 | S24 | ochoa | GRAM domain-containing protein 4 (Death-inducing protein) | Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8CB44, ECO:0000269|PubMed:15565177}. |
| Q6JBY9 | RCSD1 | S108 | ochoa|psp | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NY19 | KANK3 | S152 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Q6PGN9 | PSRC1 | S122 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6PGQ7 | BORA | S252 | ochoa|psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6PJF5 | RHBDF2 | S309 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6UVJ0 | SASS6 | S510 | ochoa|psp | Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) | Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). {ECO:0000250|UniProtKB:Q7ZVT3, ECO:0000250|UniProtKB:Q80UK7, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:22020124}. |
| Q6VAB6 | KSR2 | S357 | ochoa | Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1) | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126}. |
| Q6WCQ1 | MPRIP | S619 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZRI6 | C15orf39 | S108 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZRI6 | C15orf39 | S391 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZSR9 | None | S186 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q71F56 | MED13L | S826 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q71RG4 | TMUB2 | S154 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 2 | None |
| Q76MJ5 | ERN2 | S902 | ochoa | Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}. |
| Q76N32 | CEP68 | S349 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7Z2K8 | GPRIN1 | S615 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S820 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z401 | DENND4A | S1240 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q86SQ0 | PHLDB2 | S173 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86TB3 | ALPK2 | S1698 | ochoa | Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase) | Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). {ECO:0000269|PubMed:29888752, ECO:0000303|PubMed:10021370}. |
| Q86TC9 | MYPN | S108 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86U70 | LDB1 | S381 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86X10 | RALGAPB | S1316 | ochoa | Ral GTPase-activating protein subunit beta (p170) | Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q86XR8 | CEP57 | S34 | ochoa | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}. |
| Q86YW5 | TREML1 | S236 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IUD2 | ERC1 | S94 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IVF2 | AHNAK2 | S4419 | ochoa | Protein AHNAK2 | None |
| Q8IWY8 | ZSCAN29 | S153 | ochoa | Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) | May be involved in transcriptional regulation. |
| Q8IX90 | SKA3 | S267 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8IY92 | SLX4 | S1469 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N205 | SYNE4 | S331 | ochoa | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}. |
| Q8N264 | ARHGAP24 | S415 | ochoa|psp | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8N3V7 | SYNPO | S501 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4C8 | MINK1 | S918 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NEN9 | PDZD8 | S538 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8NFP9 | NBEA | S1321 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8NHU6 | TDRD7 | S159 | ochoa | Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269|PubMed:21436445}. |
| Q8TEK3 | DOT1L | S1009 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8TF44 | C2CD4C | S273 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WVV4 | POF1B | S98 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WWN9 | IPCEF1 | S411 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q8WY91 | THAP4 | S283 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q8WYQ5 | DGCR8 | S385 | ochoa | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
| Q92538 | GBF1 | S314 | ochoa | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) | Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}. |
| Q92630 | DYRK2 | S30 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. |
| Q92797 | SYMPK | S1243 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q96BY7 | ATG2B | S899 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
| Q96CX2 | KCTD12 | S176 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96FF9 | CDCA5 | S181 | ochoa|psp | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Q96HJ3 | CCDC34 | S52 | ochoa | Coiled-coil domain-containing protein 34 (Renal carcinoma antigen NY-REN-41) | Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella. {ECO:0000269|PubMed:34348960}. |
| Q96PP8 | GBP5 | S157 | ochoa | Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448). {ECO:0000250|UniProtKB:Q8CFB4, ECO:0000269|PubMed:20180847, ECO:0000269|PubMed:22461501, ECO:0000269|PubMed:26996307, ECO:0000269|PubMed:31091448}.; FUNCTION: Antigenic tumor-specific truncated splice form. {ECO:0000269|PubMed:15175044}. |
| Q99569 | PKP4 | S406 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99618 | CDCA3 | S68 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S805 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BZ71 | PITPNM3 | S495 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9BZL4 | PPP1R12C | S476 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C073 | FAM117A | S178 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0D7 | ZC3H12C | S123 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9H165 | BCL11A | S205 | ochoa | BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) | Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}. |
| Q9H257 | CARD9 | S460 | ochoa | Caspase recruitment domain-containing protein 9 (hCARD9) | Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25057046, PubMed:25702837, PubMed:26521038, PubMed:26679537, PubMed:26961233, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:26961233, PubMed:31296852, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}. |
| Q9H2Y7 | ZNF106 | S452 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H3P2 | NELFA | S225 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H4E7 | DEF6 | S597 | ochoa|psp | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H4M7 | PLEKHA4 | S229 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H792 | PEAK1 | S587 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9NQ86 | TRIM36 | S80 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NRA8 | EIF4ENIF1 | S564 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NW68 | BSDC1 | S329 | ochoa | BSD domain-containing protein 1 | None |
| Q9NZL9 | MAT2B | S273 | ochoa | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| Q9NZM1 | MYOF | S1915 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9NZT2 | OGFR | S315 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P107 | GMIP | S914 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P1Z0 | ZBTB4 | S391 | ochoa | Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) | Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}. |
| Q9P203 | BTBD7 | S722 | ochoa | BTB/POZ domain-containing protein 7 | Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}. |
| Q9P242 | NYAP2 | S413 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P246 | STIM2 | S640 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P275 | USP36 | S667 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UGP4 | LIMD1 | S272 | ochoa|psp | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UKE5 | TNIK | S680 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UKI2 | CDC42EP3 | S124 | ochoa | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| Q9ULD4 | BRPF3 | S959 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULU4 | ZMYND8 | S24 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9ULU4 | ZMYND8 | S668 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UN30 | SCML1 | S138 | ochoa | Sex comb on midleg-like protein 1 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}. |
| Q9UPT8 | ZC3H4 | S159 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPY3 | DICER1 | S1852 | ochoa|psp | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9UQ35 | SRRM2 | S1179 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2W1 | THRAP3 | S248 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y566 | SHANK1 | S2000 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Q9Y6D6 | ARFGEF1 | S234 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6I9 | TEX264 | S71 | ochoa | Testis-expressed protein 264 (Putative secreted protein Zsig11) | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}. |
| P31152 | MAPK4 | S196 | GPS6|ELM|iPTMNet|EPSD | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000046 | 4.334 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000046 | 4.334 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000108 | 3.967 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.000146 | 3.836 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.000552 | 3.258 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000551 | 3.259 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000489 | 3.311 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.000955 | 3.020 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000867 | 3.062 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.002117 | 2.674 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.001624 | 2.790 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.002117 | 2.674 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.001530 | 2.815 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.001425 | 2.846 |
| R-HSA-2559583 | Cellular Senescence | 0.001881 | 2.726 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.001787 | 2.748 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.003709 | 2.431 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.003709 | 2.431 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.003556 | 2.449 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.005711 | 2.243 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.005711 | 2.243 |
| R-HSA-525793 | Myogenesis | 0.005686 | 2.245 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.005487 | 2.261 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.007263 | 2.139 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.011125 | 1.954 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.010414 | 1.982 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.009730 | 2.012 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.011125 | 1.954 |
| R-HSA-157118 | Signaling by NOTCH | 0.009089 | 2.041 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.009730 | 2.012 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.009730 | 2.012 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.011084 | 1.955 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.011084 | 1.955 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.011863 | 1.926 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.014245 | 1.846 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.013876 | 1.858 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.013423 | 1.872 |
| R-HSA-5693538 | Homology Directed Repair | 0.016617 | 1.779 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.015690 | 1.804 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.016721 | 1.777 |
| R-HSA-196780 | Biotin transport and metabolism | 0.019319 | 1.714 |
| R-HSA-171007 | p38MAPK events | 0.019319 | 1.714 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.021988 | 1.658 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.021988 | 1.658 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.029736 | 1.527 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.036835 | 1.434 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.038087 | 1.419 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.043495 | 1.362 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.039331 | 1.405 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.026307 | 1.580 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.026307 | 1.580 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.036876 | 1.433 |
| R-HSA-69275 | G2/M Transition | 0.027938 | 1.554 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.029093 | 1.536 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.043238 | 1.364 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.038027 | 1.420 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.020758 | 1.683 |
| R-HSA-9675135 | Diseases of DNA repair | 0.022909 | 1.640 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.023262 | 1.633 |
| R-HSA-1640170 | Cell Cycle | 0.033833 | 1.471 |
| R-HSA-450294 | MAP kinase activation | 0.042434 | 1.372 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.023262 | 1.633 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.034402 | 1.463 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.034402 | 1.463 |
| R-HSA-167044 | Signalling to RAS | 0.034402 | 1.463 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.036835 | 1.434 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.044511 | 1.352 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.045508 | 1.342 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.045508 | 1.342 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.046204 | 1.335 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.054072 | 1.267 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.054072 | 1.267 |
| R-HSA-8941237 | Invadopodia formation | 0.054072 | 1.267 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.064532 | 1.190 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.064532 | 1.190 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.048690 | 1.313 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.049927 | 1.302 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.058105 | 1.236 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.070566 | 1.151 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.064532 | 1.190 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.047190 | 1.326 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.064300 | 1.192 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.064419 | 1.191 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.064047 | 1.194 |
| R-HSA-212436 | Generic Transcription Pathway | 0.069662 | 1.157 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.056890 | 1.245 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.053893 | 1.268 |
| R-HSA-448424 | Interleukin-17 signaling | 0.057105 | 1.243 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.058467 | 1.233 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.049927 | 1.302 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.060652 | 1.217 |
| R-HSA-194138 | Signaling by VEGF | 0.072061 | 1.142 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.074877 | 1.126 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.074877 | 1.126 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.085108 | 1.070 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.085108 | 1.070 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.095227 | 1.021 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.115132 | 0.939 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.124921 | 0.903 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.153645 | 0.813 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.163010 | 0.788 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.163010 | 0.788 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.163010 | 0.788 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.172272 | 0.764 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.172272 | 0.764 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.208311 | 0.681 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.086707 | 1.062 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.217075 | 0.663 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.234313 | 0.630 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.234313 | 0.630 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.242790 | 0.615 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.242790 | 0.615 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.242790 | 0.615 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.242790 | 0.615 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.242790 | 0.615 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.259465 | 0.586 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.144190 | 0.841 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.291727 | 0.535 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.187175 | 0.728 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.187175 | 0.728 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.199198 | 0.701 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.207264 | 0.683 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.227568 | 0.643 |
| R-HSA-380287 | Centrosome maturation | 0.235731 | 0.628 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.132868 | 0.877 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.251174 | 0.600 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.239819 | 0.620 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.105235 | 0.978 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.117640 | 0.929 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.115132 | 0.939 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.148009 | 0.830 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.163010 | 0.788 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.215365 | 0.667 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.086707 | 1.062 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.103824 | 0.984 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.125440 | 0.902 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.083990 | 1.076 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.272602 | 0.564 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.095227 | 1.021 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.172272 | 0.764 |
| R-HSA-68877 | Mitotic Prometaphase | 0.211365 | 0.675 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.103824 | 0.984 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.121765 | 0.914 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.121765 | 0.914 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.121765 | 0.914 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.086086 | 1.065 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.134602 | 0.871 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.172272 | 0.764 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.172272 | 0.764 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.225741 | 0.646 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.283795 | 0.547 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.283795 | 0.547 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.231647 | 0.635 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.121765 | 0.914 |
| R-HSA-9824272 | Somitogenesis | 0.118118 | 0.928 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.101711 | 0.993 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.179219 | 0.747 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.219426 | 0.659 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 0.074877 | 1.126 |
| R-HSA-1483226 | Synthesis of PI | 0.144176 | 0.841 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.208311 | 0.681 |
| R-HSA-420029 | Tight junction interactions | 0.291727 | 0.535 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.183190 | 0.737 |
| R-HSA-1500620 | Meiosis | 0.276702 | 0.558 |
| R-HSA-69481 | G2/M Checkpoints | 0.210608 | 0.677 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.095227 | 1.021 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.100330 | 0.999 |
| R-HSA-199920 | CREB phosphorylation | 0.095227 | 1.021 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.105235 | 0.978 |
| R-HSA-1462054 | Alpha-defensins | 0.115132 | 0.939 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.163010 | 0.788 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.190491 | 0.720 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.199451 | 0.700 |
| R-HSA-163615 | PKA activation | 0.225741 | 0.646 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.242790 | 0.615 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.260300 | 0.585 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.144176 | 0.841 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.085108 | 1.070 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.190491 | 0.720 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.118118 | 0.928 |
| R-HSA-74160 | Gene expression (Transcription) | 0.113064 | 0.947 |
| R-HSA-445144 | Signal transduction by L1 | 0.242790 | 0.615 |
| R-HSA-114608 | Platelet degranulation | 0.210608 | 0.677 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.124921 | 0.903 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.190491 | 0.720 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.208311 | 0.681 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.086707 | 1.062 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.090345 | 1.044 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.291727 | 0.535 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.291727 | 0.535 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.183190 | 0.737 |
| R-HSA-198753 | ERK/MAPK targets | 0.251174 | 0.600 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.251174 | 0.600 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.159583 | 0.797 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.230860 | 0.637 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.144927 | 0.839 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.172272 | 0.764 |
| R-HSA-9758941 | Gastrulation | 0.284310 | 0.546 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.163010 | 0.788 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.219426 | 0.659 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.230382 | 0.638 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.115132 | 0.939 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.242790 | 0.615 |
| R-HSA-200425 | Carnitine shuttle | 0.275775 | 0.559 |
| R-HSA-73894 | DNA Repair | 0.249257 | 0.603 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.283795 | 0.547 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.283795 | 0.547 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.150181 | 0.823 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.138025 | 0.860 |
| R-HSA-162582 | Signal Transduction | 0.188411 | 0.725 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.283795 | 0.547 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.267665 | 0.572 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.122459 | 0.912 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.122459 | 0.912 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.122459 | 0.912 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.114499 | 0.941 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.225741 | 0.646 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.152795 | 0.816 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.248005 | 0.606 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.155424 | 0.808 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.185214 | 0.732 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.155424 | 0.808 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.185214 | 0.732 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.193588 | 0.713 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.142428 | 0.846 |
| R-HSA-9945266 | Differentiation of T cells | 0.199451 | 0.700 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.199451 | 0.700 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.129142 | 0.889 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.193588 | 0.713 |
| R-HSA-2262752 | Cellular responses to stress | 0.266941 | 0.574 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.124896 | 0.903 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.227568 | 0.643 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.163394 | 0.787 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.171484 | 0.766 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.275775 | 0.559 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.231647 | 0.635 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.076523 | 1.116 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.280800 | 0.552 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.281304 | 0.551 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.290328 | 0.537 |
| R-HSA-163685 | Integration of energy metabolism | 0.242591 | 0.615 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.083396 | 1.079 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.185214 | 0.732 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.118790 | 0.925 |
| R-HSA-187687 | Signalling to ERKs | 0.080124 | 1.096 |
| R-HSA-166520 | Signaling by NTRKs | 0.115093 | 0.939 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.261172 | 0.583 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.293084 | 0.533 |
| R-HSA-73887 | Death Receptor Signaling | 0.299374 | 0.524 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.299572 | 0.523 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.301258 | 0.521 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.307331 | 0.512 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.307331 | 0.512 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.307331 | 0.512 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.307331 | 0.512 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.307331 | 0.512 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.313490 | 0.504 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.315004 | 0.502 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.315004 | 0.502 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.315004 | 0.502 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.315004 | 0.502 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.329588 | 0.482 |
| R-HSA-2424491 | DAP12 signaling | 0.330097 | 0.481 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.330097 | 0.481 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.330097 | 0.481 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.333768 | 0.477 |
| R-HSA-1296071 | Potassium Channels | 0.333768 | 0.477 |
| R-HSA-186763 | Downstream signal transduction | 0.337519 | 0.472 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.344859 | 0.462 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.344859 | 0.462 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.345855 | 0.461 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.349868 | 0.456 |
| R-HSA-4839726 | Chromatin organization | 0.350546 | 0.455 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.352119 | 0.453 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.352119 | 0.453 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.352119 | 0.453 |
| R-HSA-9930044 | Nuclear RNA decay | 0.352119 | 0.453 |
| R-HSA-9733709 | Cardiogenesis | 0.352119 | 0.453 |
| R-HSA-354192 | Integrin signaling | 0.352119 | 0.453 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.357870 | 0.446 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.366398 | 0.436 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.366398 | 0.436 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.366398 | 0.436 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.373420 | 0.428 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.373420 | 0.428 |
| R-HSA-8853659 | RET signaling | 0.380365 | 0.420 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.380365 | 0.420 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.380365 | 0.420 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.380365 | 0.420 |
| R-HSA-111933 | Calmodulin induced events | 0.380365 | 0.420 |
| R-HSA-111997 | CaM pathway | 0.380365 | 0.420 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.380365 | 0.420 |
| R-HSA-211000 | Gene Silencing by RNA | 0.381653 | 0.418 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.389850 | 0.409 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.400743 | 0.397 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.400743 | 0.397 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.400743 | 0.397 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.407387 | 0.390 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.407387 | 0.390 |
| R-HSA-167169 | HIV Transcription Elongation | 0.407387 | 0.390 |
| R-HSA-9646399 | Aggrephagy | 0.407387 | 0.390 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.407387 | 0.390 |
| R-HSA-5617833 | Cilium Assembly | 0.410669 | 0.387 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.413626 | 0.383 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.413957 | 0.383 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.413957 | 0.383 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.420455 | 0.376 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.420455 | 0.376 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.422473 | 0.374 |
| R-HSA-373760 | L1CAM interactions | 0.424240 | 0.372 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.426881 | 0.370 |
| R-HSA-111996 | Ca-dependent events | 0.426881 | 0.370 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.428038 | 0.369 |
| R-HSA-1461973 | Defensins | 0.433236 | 0.363 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.439521 | 0.357 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.439521 | 0.357 |
| R-HSA-69236 | G1 Phase | 0.439521 | 0.357 |
| R-HSA-2172127 | DAP12 interactions | 0.439521 | 0.357 |
| R-HSA-156581 | Methylation | 0.439521 | 0.357 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.439521 | 0.357 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.443098 | 0.354 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.443098 | 0.354 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.445737 | 0.351 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.445737 | 0.351 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.450156 | 0.347 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.450546 | 0.346 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.451885 | 0.345 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.451885 | 0.345 |
| R-HSA-75153 | Apoptotic execution phase | 0.451885 | 0.345 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.463977 | 0.334 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.467185 | 0.331 |
| R-HSA-199991 | Membrane Trafficking | 0.467406 | 0.330 |
| R-HSA-73893 | DNA Damage Bypass | 0.469923 | 0.328 |
| R-HSA-9748787 | Azathioprine ADME | 0.475803 | 0.323 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.481619 | 0.317 |
| R-HSA-912446 | Meiotic recombination | 0.481619 | 0.317 |
| R-HSA-1474165 | Reproduction | 0.483352 | 0.316 |
| R-HSA-9843745 | Adipogenesis | 0.486923 | 0.313 |
| R-HSA-5576891 | Cardiac conduction | 0.486923 | 0.313 |
| R-HSA-72187 | mRNA 3'-end processing | 0.487371 | 0.312 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.487371 | 0.312 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.487371 | 0.312 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.490478 | 0.309 |
| R-HSA-1221632 | Meiotic synapsis | 0.493059 | 0.307 |
| R-HSA-72649 | Translation initiation complex formation | 0.498684 | 0.302 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.504247 | 0.297 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.504247 | 0.297 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.509749 | 0.293 |
| R-HSA-75893 | TNF signaling | 0.509749 | 0.293 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.514930 | 0.288 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.520571 | 0.284 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.524005 | 0.281 |
| R-HSA-186712 | Regulation of beta-cell development | 0.525893 | 0.279 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.531156 | 0.275 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.531156 | 0.275 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.531156 | 0.275 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.531156 | 0.275 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.531156 | 0.275 |
| R-HSA-379724 | tRNA Aminoacylation | 0.531156 | 0.275 |
| R-HSA-8957322 | Metabolism of steroids | 0.533201 | 0.273 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.536360 | 0.271 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.536360 | 0.271 |
| R-HSA-112043 | PLC beta mediated events | 0.536360 | 0.271 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.537668 | 0.269 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.541508 | 0.266 |
| R-HSA-9707616 | Heme signaling | 0.541508 | 0.266 |
| R-HSA-186797 | Signaling by PDGF | 0.541508 | 0.266 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.541508 | 0.266 |
| R-HSA-8848021 | Signaling by PTK6 | 0.546598 | 0.262 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.546598 | 0.262 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.548434 | 0.261 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.551633 | 0.258 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.551633 | 0.258 |
| R-HSA-69242 | S Phase | 0.551767 | 0.258 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.556611 | 0.254 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.556611 | 0.254 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.560464 | 0.251 |
| R-HSA-112040 | G-protein mediated events | 0.566404 | 0.247 |
| R-HSA-167172 | Transcription of the HIV genome | 0.571220 | 0.243 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.571220 | 0.243 |
| R-HSA-1989781 | PPARA activates gene expression | 0.574169 | 0.241 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.580419 | 0.236 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.580692 | 0.236 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.580692 | 0.236 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.585350 | 0.233 |
| R-HSA-877300 | Interferon gamma signaling | 0.586603 | 0.232 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.589956 | 0.229 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.589956 | 0.229 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.589956 | 0.229 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.594512 | 0.226 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.601767 | 0.221 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.616545 | 0.210 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.622649 | 0.206 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.629189 | 0.201 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.633311 | 0.198 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.633311 | 0.198 |
| R-HSA-112316 | Neuronal System | 0.635889 | 0.197 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.637387 | 0.196 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.645405 | 0.190 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.647773 | 0.189 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.649348 | 0.188 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.649348 | 0.188 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.654417 | 0.184 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.657103 | 0.182 |
| R-HSA-68886 | M Phase | 0.657459 | 0.182 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.659363 | 0.181 |
| R-HSA-3781865 | Diseases of glycosylation | 0.660882 | 0.180 |
| R-HSA-9663891 | Selective autophagy | 0.660916 | 0.180 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.660916 | 0.180 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.675752 | 0.170 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.681488 | 0.167 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.686478 | 0.163 |
| R-HSA-195721 | Signaling by WNT | 0.688342 | 0.162 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.693392 | 0.159 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.696804 | 0.157 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.696804 | 0.157 |
| R-HSA-1266738 | Developmental Biology | 0.698975 | 0.156 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.701066 | 0.154 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.703514 | 0.153 |
| R-HSA-3214847 | HATs acetylate histones | 0.706814 | 0.151 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.707224 | 0.150 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.710078 | 0.149 |
| R-HSA-72172 | mRNA Splicing | 0.712791 | 0.147 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.716496 | 0.145 |
| R-HSA-1483255 | PI Metabolism | 0.716496 | 0.145 |
| R-HSA-111885 | Opioid Signalling | 0.722773 | 0.141 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.725860 | 0.139 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.725860 | 0.139 |
| R-HSA-9833110 | RSV-host interactions | 0.725860 | 0.139 |
| R-HSA-397014 | Muscle contraction | 0.730752 | 0.136 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.730752 | 0.136 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.731931 | 0.136 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.737868 | 0.132 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.737868 | 0.132 |
| R-HSA-68882 | Mitotic Anaphase | 0.739372 | 0.131 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.740788 | 0.130 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.741490 | 0.130 |
| R-HSA-6803157 | Antimicrobial peptides | 0.746530 | 0.127 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.749353 | 0.125 |
| R-HSA-8951664 | Neddylation | 0.749817 | 0.125 |
| R-HSA-422475 | Axon guidance | 0.757035 | 0.121 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.757638 | 0.121 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.763008 | 0.117 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.765649 | 0.116 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.765649 | 0.116 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.767717 | 0.115 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.768261 | 0.114 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.770844 | 0.113 |
| R-HSA-3371556 | Cellular response to heat stress | 0.778421 | 0.109 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.783334 | 0.106 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.785750 | 0.105 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.790501 | 0.102 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.790501 | 0.102 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.790501 | 0.102 |
| R-HSA-69206 | G1/S Transition | 0.790501 | 0.102 |
| R-HSA-9675108 | Nervous system development | 0.803447 | 0.095 |
| R-HSA-421270 | Cell-cell junction organization | 0.805222 | 0.094 |
| R-HSA-9909396 | Circadian clock | 0.808481 | 0.092 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.818930 | 0.087 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.820951 | 0.086 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.824925 | 0.084 |
| R-HSA-9664407 | Parasite infection | 0.826879 | 0.083 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.826879 | 0.083 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.826879 | 0.083 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.828812 | 0.082 |
| R-HSA-1632852 | Macroautophagy | 0.828812 | 0.082 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.832613 | 0.080 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.832613 | 0.080 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.839965 | 0.076 |
| R-HSA-446728 | Cell junction organization | 0.845518 | 0.073 |
| R-HSA-449147 | Signaling by Interleukins | 0.848332 | 0.071 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.849497 | 0.071 |
| R-HSA-9658195 | Leishmania infection | 0.849497 | 0.071 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.850395 | 0.070 |
| R-HSA-2142753 | Arachidonate metabolism | 0.850395 | 0.070 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.853719 | 0.069 |
| R-HSA-9612973 | Autophagy | 0.856970 | 0.067 |
| R-HSA-162587 | HIV Life Cycle | 0.858568 | 0.066 |
| R-HSA-109581 | Apoptosis | 0.866297 | 0.062 |
| R-HSA-1483257 | Phospholipid metabolism | 0.866867 | 0.062 |
| R-HSA-5668914 | Diseases of metabolism | 0.877205 | 0.057 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.880518 | 0.055 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.883176 | 0.054 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.883176 | 0.054 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.883176 | 0.054 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.884483 | 0.053 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.885775 | 0.053 |
| R-HSA-1500931 | Cell-Cell communication | 0.889510 | 0.051 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.896232 | 0.048 |
| R-HSA-9609690 | HCMV Early Events | 0.909827 | 0.041 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.912614 | 0.040 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.916667 | 0.038 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.916667 | 0.038 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.916667 | 0.038 |
| R-HSA-5357801 | Programmed Cell Death | 0.919438 | 0.036 |
| R-HSA-6805567 | Keratinization | 0.920341 | 0.036 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.924956 | 0.034 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.928560 | 0.032 |
| R-HSA-418990 | Adherens junctions interactions | 0.930424 | 0.031 |
| R-HSA-9748784 | Drug ADME | 0.930424 | 0.031 |
| R-HSA-162906 | HIV Infection | 0.937144 | 0.028 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.937850 | 0.028 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.938548 | 0.028 |
| R-HSA-913531 | Interferon Signaling | 0.940645 | 0.027 |
| R-HSA-8939211 | ESR-mediated signaling | 0.943856 | 0.025 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.945110 | 0.025 |
| R-HSA-109582 | Hemostasis | 0.947561 | 0.023 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.947927 | 0.023 |
| R-HSA-9609646 | HCMV Infection | 0.951527 | 0.022 |
| R-HSA-8978868 | Fatty acid metabolism | 0.952601 | 0.021 |
| R-HSA-5688426 | Deubiquitination | 0.954192 | 0.020 |
| R-HSA-72766 | Translation | 0.961519 | 0.017 |
| R-HSA-8953854 | Metabolism of RNA | 0.963790 | 0.016 |
| R-HSA-1643685 | Disease | 0.968718 | 0.014 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.970877 | 0.013 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.978804 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.980646 | 0.008 |
| R-HSA-1280218 | Adaptive Immune System | 0.980884 | 0.008 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.984228 | 0.007 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.986551 | 0.006 |
| R-HSA-9679506 | SARS-CoV Infections | 0.988742 | 0.005 |
| R-HSA-556833 | Metabolism of lipids | 0.988854 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 0.991949 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 0.993827 | 0.003 |
| R-HSA-168249 | Innate Immune System | 0.994116 | 0.003 |
| R-HSA-6798695 | Neutrophil degranulation | 0.995456 | 0.002 |
| R-HSA-9824446 | Viral Infection Pathways | 0.996493 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.997184 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.997870 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.998784 | 0.001 |
| R-HSA-168256 | Immune System | 0.998952 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999701 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999870 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999906 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999961 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999980 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.856 | 0.807 | 1 | 0.875 |
CDK17 |
0.852 | 0.807 | 1 | 0.897 |
HIPK2 |
0.852 | 0.739 | 1 | 0.848 |
KIS |
0.847 | 0.689 | 1 | 0.804 |
CDK16 |
0.847 | 0.786 | 1 | 0.889 |
P38G |
0.841 | 0.790 | 1 | 0.900 |
CDK14 |
0.839 | 0.801 | 1 | 0.833 |
CDK19 |
0.839 | 0.728 | 1 | 0.856 |
CDK3 |
0.839 | 0.662 | 1 | 0.895 |
CDK7 |
0.838 | 0.749 | 1 | 0.835 |
DYRK2 |
0.837 | 0.725 | 1 | 0.771 |
HIPK1 |
0.836 | 0.708 | 1 | 0.752 |
CDK1 |
0.836 | 0.724 | 1 | 0.852 |
JNK2 |
0.836 | 0.795 | 1 | 0.862 |
DYRK4 |
0.836 | 0.735 | 1 | 0.861 |
CDK13 |
0.834 | 0.743 | 1 | 0.850 |
CDK12 |
0.833 | 0.750 | 1 | 0.864 |
DYRK1B |
0.833 | 0.725 | 1 | 0.819 |
ERK1 |
0.833 | 0.753 | 1 | 0.850 |
P38D |
0.832 | 0.769 | 1 | 0.917 |
CDK8 |
0.832 | 0.723 | 1 | 0.824 |
CDK10 |
0.831 | 0.718 | 1 | 0.850 |
CDK5 |
0.830 | 0.704 | 1 | 0.814 |
CDK9 |
0.827 | 0.736 | 1 | 0.841 |
CLK3 |
0.826 | 0.466 | 1 | 0.552 |
JNK3 |
0.826 | 0.776 | 1 | 0.841 |
HIPK4 |
0.826 | 0.491 | 1 | 0.570 |
P38B |
0.826 | 0.740 | 1 | 0.837 |
DYRK1A |
0.825 | 0.630 | 1 | 0.737 |
SRPK1 |
0.824 | 0.381 | -3 | 0.820 |
HIPK3 |
0.823 | 0.680 | 1 | 0.718 |
ERK2 |
0.819 | 0.755 | 1 | 0.801 |
P38A |
0.819 | 0.717 | 1 | 0.777 |
NLK |
0.816 | 0.684 | 1 | 0.573 |
CDK4 |
0.815 | 0.728 | 1 | 0.873 |
DYRK3 |
0.815 | 0.573 | 1 | 0.714 |
CLK2 |
0.814 | 0.427 | -3 | 0.806 |
CLK1 |
0.813 | 0.450 | -3 | 0.792 |
CDK6 |
0.813 | 0.700 | 1 | 0.851 |
SRPK2 |
0.812 | 0.318 | -3 | 0.764 |
JNK1 |
0.811 | 0.701 | 1 | 0.866 |
CLK4 |
0.808 | 0.415 | -3 | 0.815 |
CDK2 |
0.807 | 0.545 | 1 | 0.736 |
ERK5 |
0.805 | 0.389 | 1 | 0.502 |
MAK |
0.801 | 0.497 | -2 | 0.706 |
SRPK3 |
0.801 | 0.281 | -3 | 0.800 |
ICK |
0.799 | 0.378 | -3 | 0.881 |
CDKL5 |
0.799 | 0.212 | -3 | 0.861 |
MOK |
0.793 | 0.481 | 1 | 0.652 |
CDKL1 |
0.793 | 0.199 | -3 | 0.864 |
MTOR |
0.793 | 0.174 | 1 | 0.360 |
COT |
0.792 | -0.040 | 2 | 0.841 |
PRKD1 |
0.788 | 0.070 | -3 | 0.865 |
NDR2 |
0.787 | 0.036 | -3 | 0.862 |
PRKD2 |
0.787 | 0.083 | -3 | 0.820 |
RSK2 |
0.785 | 0.078 | -3 | 0.832 |
PIM3 |
0.785 | 0.020 | -3 | 0.873 |
CDC7 |
0.784 | -0.070 | 1 | 0.222 |
NUAK2 |
0.784 | 0.079 | -3 | 0.863 |
NDR1 |
0.783 | 0.035 | -3 | 0.861 |
P90RSK |
0.783 | 0.086 | -3 | 0.838 |
PRP4 |
0.782 | 0.410 | -3 | 0.743 |
MOS |
0.782 | -0.020 | 1 | 0.265 |
RSK3 |
0.782 | 0.067 | -3 | 0.831 |
CAMK1B |
0.781 | 0.043 | -3 | 0.880 |
WNK1 |
0.781 | 0.008 | -2 | 0.895 |
PIM1 |
0.781 | 0.084 | -3 | 0.832 |
PKN3 |
0.781 | 0.020 | -3 | 0.862 |
RIPK3 |
0.780 | 0.032 | 3 | 0.709 |
SKMLCK |
0.780 | 0.068 | -2 | 0.882 |
PRPK |
0.780 | -0.083 | -1 | 0.799 |
MST4 |
0.780 | 0.012 | 2 | 0.861 |
AURC |
0.778 | 0.066 | -2 | 0.675 |
TBK1 |
0.777 | -0.134 | 1 | 0.148 |
ATR |
0.777 | -0.034 | 1 | 0.266 |
NEK6 |
0.777 | -0.054 | -2 | 0.862 |
CAMLCK |
0.776 | 0.064 | -2 | 0.858 |
NIK |
0.776 | 0.025 | -3 | 0.879 |
RAF1 |
0.775 | -0.120 | 1 | 0.188 |
LATS2 |
0.775 | 0.017 | -5 | 0.761 |
GCN2 |
0.775 | -0.183 | 2 | 0.815 |
PKCD |
0.775 | 0.023 | 2 | 0.785 |
CHAK2 |
0.775 | -0.028 | -1 | 0.857 |
PKN2 |
0.775 | -0.002 | -3 | 0.853 |
P70S6KB |
0.775 | 0.056 | -3 | 0.842 |
AMPKA1 |
0.774 | 0.010 | -3 | 0.867 |
PRKD3 |
0.774 | 0.080 | -3 | 0.798 |
DAPK2 |
0.774 | 0.053 | -3 | 0.884 |
IKKB |
0.773 | -0.147 | -2 | 0.773 |
NUAK1 |
0.773 | 0.049 | -3 | 0.829 |
PDHK4 |
0.773 | -0.141 | 1 | 0.252 |
DSTYK |
0.773 | -0.113 | 2 | 0.858 |
ULK2 |
0.772 | -0.159 | 2 | 0.793 |
PKACG |
0.772 | 0.025 | -2 | 0.758 |
IKKE |
0.772 | -0.158 | 1 | 0.145 |
ERK7 |
0.772 | 0.252 | 2 | 0.561 |
MARK4 |
0.771 | -0.021 | 4 | 0.848 |
NEK7 |
0.771 | -0.110 | -3 | 0.848 |
NIM1 |
0.771 | -0.007 | 3 | 0.632 |
MAPKAPK3 |
0.771 | 0.002 | -3 | 0.828 |
IRE1 |
0.771 | -0.041 | 1 | 0.193 |
HUNK |
0.770 | -0.093 | 2 | 0.803 |
AMPKA2 |
0.770 | 0.019 | -3 | 0.848 |
TGFBR2 |
0.770 | -0.061 | -2 | 0.802 |
TSSK1 |
0.770 | 0.019 | -3 | 0.880 |
BMPR2 |
0.770 | -0.176 | -2 | 0.882 |
RSK4 |
0.769 | 0.071 | -3 | 0.809 |
MNK2 |
0.769 | 0.018 | -2 | 0.813 |
AKT2 |
0.769 | 0.099 | -3 | 0.760 |
MNK1 |
0.769 | 0.041 | -2 | 0.821 |
PHKG1 |
0.768 | 0.003 | -3 | 0.848 |
MAPKAPK2 |
0.768 | 0.017 | -3 | 0.798 |
PKCB |
0.767 | 0.014 | 2 | 0.734 |
MSK2 |
0.767 | 0.035 | -3 | 0.817 |
PDHK1 |
0.767 | -0.158 | 1 | 0.227 |
MELK |
0.767 | 0.013 | -3 | 0.838 |
CAMK2G |
0.767 | -0.102 | 2 | 0.786 |
IRE2 |
0.767 | -0.022 | 2 | 0.758 |
WNK3 |
0.766 | -0.107 | 1 | 0.190 |
PKACB |
0.766 | 0.064 | -2 | 0.694 |
SGK3 |
0.766 | 0.067 | -3 | 0.814 |
AURB |
0.765 | 0.042 | -2 | 0.672 |
PKCZ |
0.765 | 0.005 | 2 | 0.786 |
PKCG |
0.765 | 0.008 | 2 | 0.729 |
TSSK2 |
0.765 | -0.027 | -5 | 0.845 |
PIM2 |
0.765 | 0.088 | -3 | 0.808 |
PAK1 |
0.765 | 0.002 | -2 | 0.789 |
QSK |
0.765 | 0.020 | 4 | 0.839 |
CAMK2D |
0.765 | -0.050 | -3 | 0.865 |
PAK3 |
0.765 | -0.010 | -2 | 0.790 |
LATS1 |
0.765 | 0.044 | -3 | 0.869 |
PKCA |
0.764 | 0.013 | 2 | 0.736 |
MLK1 |
0.763 | -0.130 | 2 | 0.804 |
MASTL |
0.763 | -0.116 | -2 | 0.828 |
ANKRD3 |
0.763 | -0.067 | 1 | 0.208 |
ULK1 |
0.763 | -0.146 | -3 | 0.807 |
RIPK1 |
0.763 | -0.107 | 1 | 0.175 |
SIK |
0.763 | 0.029 | -3 | 0.805 |
ATM |
0.763 | -0.039 | 1 | 0.234 |
MSK1 |
0.762 | 0.045 | -3 | 0.818 |
PAK6 |
0.762 | 0.023 | -2 | 0.717 |
PRKX |
0.762 | 0.078 | -3 | 0.734 |
NEK9 |
0.762 | -0.129 | 2 | 0.846 |
CAMK4 |
0.762 | -0.049 | -3 | 0.836 |
PKG2 |
0.761 | 0.035 | -2 | 0.689 |
DNAPK |
0.761 | -0.026 | 1 | 0.240 |
QIK |
0.761 | -0.027 | -3 | 0.850 |
CAMK1G |
0.761 | 0.033 | -3 | 0.814 |
GRK1 |
0.761 | -0.056 | -2 | 0.817 |
IKKA |
0.761 | -0.112 | -2 | 0.763 |
PKR |
0.761 | -0.034 | 1 | 0.215 |
BCKDK |
0.760 | -0.136 | -1 | 0.733 |
GRK5 |
0.760 | -0.162 | -3 | 0.829 |
MLK2 |
0.760 | -0.119 | 2 | 0.822 |
BMPR1B |
0.759 | -0.043 | 1 | 0.184 |
PINK1 |
0.759 | 0.148 | 1 | 0.412 |
PKCH |
0.759 | -0.010 | 2 | 0.726 |
MLK3 |
0.758 | -0.064 | 2 | 0.739 |
MYLK4 |
0.758 | 0.030 | -2 | 0.791 |
DCAMKL1 |
0.758 | 0.028 | -3 | 0.818 |
NEK2 |
0.758 | -0.070 | 2 | 0.827 |
AKT1 |
0.757 | 0.072 | -3 | 0.771 |
CAMK2A |
0.756 | -0.008 | 2 | 0.767 |
ALK4 |
0.756 | -0.052 | -2 | 0.842 |
MAPKAPK5 |
0.756 | -0.007 | -3 | 0.805 |
PAK2 |
0.756 | -0.020 | -2 | 0.776 |
CAMK2B |
0.755 | -0.043 | 2 | 0.753 |
VRK2 |
0.755 | 0.033 | 1 | 0.295 |
CHK1 |
0.755 | -0.006 | -3 | 0.852 |
DLK |
0.755 | -0.207 | 1 | 0.195 |
PKCT |
0.755 | 0.010 | 2 | 0.736 |
BRSK1 |
0.754 | -0.024 | -3 | 0.831 |
WNK4 |
0.754 | -0.023 | -2 | 0.880 |
GRK6 |
0.754 | -0.150 | 1 | 0.189 |
MARK3 |
0.754 | -0.008 | 4 | 0.790 |
BRSK2 |
0.754 | -0.049 | -3 | 0.837 |
TTBK2 |
0.754 | -0.156 | 2 | 0.703 |
GRK7 |
0.754 | -0.038 | 1 | 0.221 |
CHAK1 |
0.753 | -0.112 | 2 | 0.787 |
MPSK1 |
0.753 | 0.032 | 1 | 0.274 |
TGFBR1 |
0.753 | -0.061 | -2 | 0.819 |
GSK3A |
0.752 | 0.162 | 4 | 0.429 |
IRAK4 |
0.752 | -0.043 | 1 | 0.172 |
PKCI |
0.752 | 0.026 | 2 | 0.754 |
PHKG2 |
0.752 | -0.020 | -3 | 0.810 |
SMMLCK |
0.752 | 0.061 | -3 | 0.855 |
P70S6K |
0.752 | 0.044 | -3 | 0.784 |
SMG1 |
0.751 | -0.080 | 1 | 0.252 |
MARK2 |
0.751 | -0.018 | 4 | 0.756 |
AKT3 |
0.751 | 0.091 | -3 | 0.715 |
FAM20C |
0.750 | -0.034 | 2 | 0.575 |
DCAMKL2 |
0.750 | 0.005 | -3 | 0.831 |
PKACA |
0.750 | 0.053 | -2 | 0.644 |
PLK1 |
0.749 | -0.133 | -2 | 0.803 |
PLK4 |
0.749 | -0.084 | 2 | 0.631 |
YSK4 |
0.749 | -0.160 | 1 | 0.162 |
PKN1 |
0.748 | 0.042 | -3 | 0.787 |
NEK5 |
0.748 | -0.053 | 1 | 0.195 |
SNRK |
0.748 | -0.099 | 2 | 0.679 |
SGK1 |
0.748 | 0.106 | -3 | 0.703 |
MLK4 |
0.748 | -0.100 | 2 | 0.718 |
PASK |
0.748 | 0.001 | -3 | 0.880 |
MEKK1 |
0.748 | -0.081 | 1 | 0.195 |
MST3 |
0.747 | -0.025 | 2 | 0.834 |
PKCE |
0.747 | 0.040 | 2 | 0.724 |
AURA |
0.747 | -0.010 | -2 | 0.646 |
PAK5 |
0.747 | 0.010 | -2 | 0.660 |
SSTK |
0.747 | -0.017 | 4 | 0.832 |
MEK1 |
0.746 | -0.144 | 2 | 0.829 |
GRK4 |
0.746 | -0.181 | -2 | 0.834 |
DAPK3 |
0.746 | 0.053 | -3 | 0.834 |
DRAK1 |
0.745 | -0.123 | 1 | 0.165 |
PAK4 |
0.745 | 0.021 | -2 | 0.663 |
MARK1 |
0.745 | -0.043 | 4 | 0.812 |
ACVR2A |
0.745 | -0.098 | -2 | 0.791 |
ACVR2B |
0.745 | -0.096 | -2 | 0.805 |
SBK |
0.744 | 0.171 | -3 | 0.664 |
CAMK1D |
0.744 | 0.035 | -3 | 0.750 |
MEK5 |
0.744 | -0.112 | 2 | 0.821 |
TLK2 |
0.744 | -0.142 | 1 | 0.187 |
PERK |
0.743 | -0.133 | -2 | 0.838 |
ALK2 |
0.743 | -0.086 | -2 | 0.821 |
CHK2 |
0.743 | 0.067 | -3 | 0.709 |
MEKK2 |
0.743 | -0.084 | 2 | 0.808 |
ZAK |
0.742 | -0.130 | 1 | 0.165 |
HRI |
0.742 | -0.147 | -2 | 0.845 |
TAO3 |
0.741 | -0.060 | 1 | 0.212 |
PDK1 |
0.741 | -0.012 | 1 | 0.217 |
BMPR1A |
0.740 | -0.062 | 1 | 0.174 |
GAK |
0.740 | -0.007 | 1 | 0.269 |
PLK3 |
0.740 | -0.136 | 2 | 0.740 |
GRK2 |
0.740 | -0.087 | -2 | 0.722 |
BRAF |
0.740 | -0.098 | -4 | 0.814 |
MEKK3 |
0.740 | -0.136 | 1 | 0.185 |
NEK11 |
0.740 | -0.078 | 1 | 0.198 |
MRCKB |
0.739 | 0.060 | -3 | 0.787 |
DAPK1 |
0.738 | 0.032 | -3 | 0.823 |
HASPIN |
0.738 | 0.082 | -1 | 0.784 |
CK1E |
0.738 | -0.034 | -3 | 0.507 |
MEKK6 |
0.738 | -0.040 | 1 | 0.195 |
BUB1 |
0.738 | 0.037 | -5 | 0.792 |
GSK3B |
0.738 | 0.031 | 4 | 0.423 |
ROCK2 |
0.737 | 0.059 | -3 | 0.824 |
LKB1 |
0.737 | -0.035 | -3 | 0.828 |
CAMK1A |
0.736 | 0.050 | -3 | 0.723 |
NEK8 |
0.736 | -0.105 | 2 | 0.817 |
PBK |
0.735 | 0.005 | 1 | 0.257 |
TLK1 |
0.735 | -0.149 | -2 | 0.836 |
NEK4 |
0.735 | -0.075 | 1 | 0.169 |
TAO2 |
0.735 | -0.064 | 2 | 0.845 |
MAP3K15 |
0.734 | -0.067 | 1 | 0.179 |
DMPK1 |
0.734 | 0.094 | -3 | 0.796 |
IRAK1 |
0.734 | -0.140 | -1 | 0.713 |
MRCKA |
0.733 | 0.039 | -3 | 0.800 |
TNIK |
0.733 | -0.045 | 3 | 0.693 |
LOK |
0.732 | -0.040 | -2 | 0.791 |
CRIK |
0.732 | 0.092 | -3 | 0.779 |
LRRK2 |
0.732 | -0.000 | 2 | 0.848 |
GCK |
0.732 | -0.087 | 1 | 0.191 |
HGK |
0.731 | -0.072 | 3 | 0.690 |
CK1D |
0.731 | -0.013 | -3 | 0.453 |
CAMKK2 |
0.730 | -0.113 | -2 | 0.779 |
NEK1 |
0.729 | -0.076 | 1 | 0.169 |
CK1G1 |
0.729 | -0.067 | -3 | 0.492 |
HPK1 |
0.729 | -0.069 | 1 | 0.183 |
KHS1 |
0.729 | -0.045 | 1 | 0.178 |
MINK |
0.728 | -0.102 | 1 | 0.164 |
KHS2 |
0.728 | -0.024 | 1 | 0.192 |
TTBK1 |
0.728 | -0.145 | 2 | 0.616 |
PKG1 |
0.727 | 0.024 | -2 | 0.606 |
CK1A2 |
0.727 | -0.033 | -3 | 0.456 |
CK2A2 |
0.727 | -0.100 | 1 | 0.177 |
NEK3 |
0.727 | -0.036 | 1 | 0.185 |
CAMKK1 |
0.727 | -0.186 | -2 | 0.782 |
ROCK1 |
0.725 | 0.049 | -3 | 0.799 |
SLK |
0.725 | -0.063 | -2 | 0.742 |
STK33 |
0.724 | -0.100 | 2 | 0.615 |
EEF2K |
0.724 | -0.108 | 3 | 0.653 |
MST2 |
0.724 | -0.138 | 1 | 0.180 |
GRK3 |
0.724 | -0.095 | -2 | 0.684 |
YSK1 |
0.723 | -0.081 | 2 | 0.823 |
BIKE |
0.722 | -0.005 | 1 | 0.262 |
AAK1 |
0.722 | 0.033 | 1 | 0.269 |
TTK |
0.720 | 0.011 | -2 | 0.820 |
TAK1 |
0.718 | -0.180 | 1 | 0.181 |
RIPK2 |
0.718 | -0.167 | 1 | 0.147 |
CK2A1 |
0.717 | -0.106 | 1 | 0.165 |
MST1 |
0.717 | -0.150 | 1 | 0.165 |
VRK1 |
0.717 | -0.183 | 2 | 0.820 |
PDHK3_TYR |
0.715 | 0.101 | 4 | 0.899 |
LIMK2_TYR |
0.714 | 0.138 | -3 | 0.882 |
MEK2 |
0.713 | -0.175 | 2 | 0.811 |
PLK2 |
0.712 | -0.094 | -3 | 0.780 |
MYO3B |
0.712 | -0.060 | 2 | 0.833 |
PKMYT1_TYR |
0.711 | 0.132 | 3 | 0.676 |
OSR1 |
0.710 | -0.108 | 2 | 0.814 |
TESK1_TYR |
0.710 | 0.031 | 3 | 0.686 |
TAO1 |
0.709 | -0.077 | 1 | 0.168 |
ASK1 |
0.709 | -0.098 | 1 | 0.176 |
MYO3A |
0.706 | -0.079 | 1 | 0.179 |
PDHK4_TYR |
0.705 | 0.005 | 2 | 0.855 |
MAP2K4_TYR |
0.704 | -0.027 | -1 | 0.801 |
MAP2K7_TYR |
0.702 | -0.093 | 2 | 0.845 |
PINK1_TYR |
0.701 | -0.093 | 1 | 0.249 |
MST1R |
0.701 | 0.001 | 3 | 0.706 |
LIMK1_TYR |
0.701 | 0.011 | 2 | 0.850 |
TNK2 |
0.700 | 0.043 | 3 | 0.706 |
MAP2K6_TYR |
0.700 | -0.044 | -1 | 0.803 |
YANK3 |
0.700 | -0.059 | 2 | 0.390 |
RET |
0.699 | -0.091 | 1 | 0.207 |
ALPHAK3 |
0.699 | -0.099 | -1 | 0.712 |
BMPR2_TYR |
0.698 | -0.041 | -1 | 0.793 |
TNK1 |
0.697 | 0.016 | 3 | 0.644 |
ROS1 |
0.697 | -0.053 | 3 | 0.662 |
PDHK1_TYR |
0.697 | -0.096 | -1 | 0.813 |
CSF1R |
0.697 | -0.012 | 3 | 0.704 |
JAK2 |
0.697 | -0.058 | 1 | 0.213 |
EPHA6 |
0.696 | -0.050 | -1 | 0.786 |
KDR |
0.696 | 0.046 | 3 | 0.709 |
JAK1 |
0.696 | 0.019 | 1 | 0.175 |
TYK2 |
0.695 | -0.130 | 1 | 0.195 |
BLK |
0.694 | 0.021 | -1 | 0.750 |
JAK3 |
0.694 | -0.047 | 1 | 0.198 |
FGFR2 |
0.694 | 0.033 | 3 | 0.696 |
DDR1 |
0.693 | -0.046 | 4 | 0.825 |
YES1 |
0.692 | -0.057 | -1 | 0.780 |
EPHB4 |
0.692 | -0.085 | -1 | 0.749 |
ABL2 |
0.692 | -0.070 | -1 | 0.737 |
TYRO3 |
0.692 | -0.117 | 3 | 0.661 |
TNNI3K_TYR |
0.691 | -0.019 | 1 | 0.223 |
NEK10_TYR |
0.691 | -0.087 | 1 | 0.172 |
FGFR1 |
0.691 | 0.026 | 3 | 0.668 |
LCK |
0.690 | -0.036 | -1 | 0.745 |
INSRR |
0.690 | -0.064 | 3 | 0.659 |
ABL1 |
0.689 | -0.076 | -1 | 0.734 |
STLK3 |
0.689 | -0.169 | 1 | 0.149 |
TEK |
0.689 | 0.023 | 3 | 0.632 |
TXK |
0.688 | -0.081 | 1 | 0.193 |
FGR |
0.688 | -0.142 | 1 | 0.201 |
DDR2 |
0.687 | 0.038 | 3 | 0.671 |
CK1A |
0.687 | -0.063 | -3 | 0.360 |
AXL |
0.686 | -0.041 | 3 | 0.705 |
PDGFRB |
0.685 | -0.116 | 3 | 0.690 |
HCK |
0.685 | -0.098 | -1 | 0.737 |
KIT |
0.685 | -0.072 | 3 | 0.692 |
MERTK |
0.683 | -0.068 | 3 | 0.690 |
FGFR3 |
0.683 | 0.011 | 3 | 0.692 |
FER |
0.683 | -0.176 | 1 | 0.214 |
MET |
0.683 | -0.051 | 3 | 0.699 |
FLT3 |
0.681 | -0.131 | 3 | 0.667 |
EPHA4 |
0.680 | -0.093 | 2 | 0.739 |
EPHB1 |
0.679 | -0.143 | 1 | 0.180 |
PDGFRA |
0.679 | -0.132 | 3 | 0.682 |
EPHA1 |
0.678 | -0.053 | 3 | 0.708 |
SRMS |
0.678 | -0.143 | 1 | 0.180 |
EPHB3 |
0.678 | -0.134 | -1 | 0.732 |
WEE1_TYR |
0.677 | -0.087 | -1 | 0.688 |
EPHB2 |
0.677 | -0.136 | -1 | 0.720 |
ALK |
0.677 | -0.120 | 3 | 0.613 |
ITK |
0.676 | -0.165 | -1 | 0.706 |
TEC |
0.676 | -0.106 | -1 | 0.659 |
FLT4 |
0.676 | -0.073 | 3 | 0.668 |
FYN |
0.675 | -0.076 | -1 | 0.730 |
FLT1 |
0.675 | -0.094 | -1 | 0.748 |
EPHA7 |
0.675 | -0.083 | 2 | 0.749 |
ERBB2 |
0.675 | -0.119 | 1 | 0.176 |
LTK |
0.674 | -0.125 | 3 | 0.632 |
INSR |
0.674 | -0.106 | 3 | 0.643 |
NTRK2 |
0.673 | -0.110 | 3 | 0.674 |
FRK |
0.673 | -0.115 | -1 | 0.743 |
BMX |
0.672 | -0.122 | -1 | 0.631 |
PTK2B |
0.672 | -0.076 | -1 | 0.712 |
NTRK1 |
0.672 | -0.139 | -1 | 0.735 |
NTRK3 |
0.671 | -0.090 | -1 | 0.692 |
LYN |
0.669 | -0.111 | 3 | 0.609 |
MATK |
0.668 | -0.080 | -1 | 0.686 |
EPHA3 |
0.668 | -0.123 | 2 | 0.717 |
BTK |
0.667 | -0.225 | -1 | 0.676 |
CK1G3 |
0.667 | -0.066 | -3 | 0.312 |
SRC |
0.667 | -0.102 | -1 | 0.737 |
EPHA8 |
0.666 | -0.092 | -1 | 0.719 |
EGFR |
0.666 | -0.095 | 1 | 0.144 |
FGFR4 |
0.665 | -0.065 | -1 | 0.691 |
YANK2 |
0.665 | -0.079 | 2 | 0.406 |
EPHA5 |
0.665 | -0.109 | 2 | 0.722 |
PTK6 |
0.663 | -0.218 | -1 | 0.667 |
MUSK |
0.662 | -0.122 | 1 | 0.135 |
PTK2 |
0.661 | -0.060 | -1 | 0.710 |
ERBB4 |
0.661 | -0.062 | 1 | 0.151 |
EPHA2 |
0.657 | -0.100 | -1 | 0.673 |
IGF1R |
0.656 | -0.124 | 3 | 0.575 |
CSK |
0.655 | -0.159 | 2 | 0.748 |
SYK |
0.653 | -0.105 | -1 | 0.685 |
CK1G2 |
0.647 | -0.069 | -3 | 0.407 |
ZAP70 |
0.647 | -0.069 | -1 | 0.620 |
FES |
0.644 | -0.124 | -1 | 0.629 |