Motif 234 (n=138)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PPC1 | PRR33 | S114 | ochoa | Proline rich 33 | None |
| A2A288 | ZC3H12D | S428 | ochoa | Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34) | May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). {ECO:0000269|PubMed:17210687, ECO:0000269|PubMed:19531561, ECO:0000269|PubMed:26134560, ECO:0000305}. |
| C9JH25 | PRRT4 | S821 | ochoa | Proline-rich transmembrane protein 4 | None |
| E7EW31 | PROB1 | S372 | ochoa | Proline-rich basic protein 1 | None |
| O00160 | MYO1F | S923 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O14607 | UTY | S765 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O14976 | GAK | S770 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15018 | PDZD2 | S1280 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15018 | PDZD2 | S1613 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O43365 | HOXA3 | S263 | ochoa | Homeobox protein Hox-A3 (Homeobox protein Hox-1E) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| O43439 | CBFA2T2 | S44 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O60885 | BRD4 | S470 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75044 | SRGAP2 | S983 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75122 | CLASP2 | S892 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75717 | WDHD1 | S958 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O94989 | ARHGEF15 | S90 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
| O95155 | UBE4B | S327 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95359 | TACC2 | S2317 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95429 | BAG4 | S283 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| P04150 | NR3C1 | S395 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P12980 | LYL1 | S52 | ochoa | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
| P13994 | YJU2B | S332 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P17483 | HOXB4 | S116 | ochoa | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P26651 | ZFP36 | S214 | psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P27986 | PIK3R1 | S83 | psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P33076 | CIITA | S280 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P41212 | ETV6 | S271 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P42694 | HELZ | S1614 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P49815 | TSC2 | S664 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P78312 | FAM193A | S270 | ochoa | Protein FAM193A (Protein IT14) | None |
| P98171 | ARHGAP4 | S899 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q01196 | RUNX1 | S266 | ochoa|psp | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q02297 | NRG1 | S444 | ochoa | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}. |
| Q04206 | RELA | S316 | ochoa|psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q07889 | SOS1 | S1078 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q12789 | GTF3C1 | S1845 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12796 | PNRC1 | S289 | ochoa | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | Nuclear receptor coactivator. May play a role in signal transduction. {ECO:0000269|PubMed:10894149}. |
| Q13029 | PRDM2 | S643 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q14185 | DOCK1 | S1761 | ochoa | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
| Q14202 | ZMYM3 | S214 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14207 | NPAT | S1302 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14687 | GSE1 | S32 | ochoa | Genetic suppressor element 1 | None |
| Q14CZ8 | HEPACAM | S377 | ochoa | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205). {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256, ECO:0000269|PubMed:22405205}. |
| Q15911 | ZFHX3 | S3677 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16538 | GPR162 | S520 | ochoa | Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein) | Orphan receptor. |
| Q16666 | IFI16 | S480 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q16666 | IFI16 | S536 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2KJY2 | KIF26B | S1773 | ochoa|psp | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M1Z3 | ARHGAP31 | S778 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32NC0 | C18orf21 | S158 | ochoa | UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) | None |
| Q3T8J9 | GON4L | S998 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q5SNT2 | TMEM201 | S501 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
| Q5SV97 | PERM1 | S172 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5T011 | SZT2 | S719 | ochoa | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}. |
| Q5T1R4 | HIVEP3 | S1895 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5TCX8 | MAP3K21 | S789 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5UIP0 | RIF1 | S402 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VWN6 | TASOR2 | S2046 | ochoa | Protein TASOR 2 | None |
| Q5W0V3 | FHIP2A | S549 | ochoa | FHF complex subunit HOOK interacting protein 2A (FHIP2A) | Required for proper functioning of the nervous system. {ECO:0000269|PubMed:31353455}. |
| Q674R7 | ATG9B | S865 | ochoa | Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}. |
| Q6F5E8 | CARMIL2 | S1120 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6P0Q8 | MAST2 | S290 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6UB99 | ANKRD11 | S1983 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6WKZ4 | RAB11FIP1 | S545 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6XZF7 | DNMBP | S1430 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q70E73 | RAPH1 | S894 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q711Q0 | CEFIP | S116 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q75VX8 | GAREM2 | S503 | ochoa | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. {ECO:0000250}. |
| Q7RTP6 | MICAL3 | S1674 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Z1 | TICRR | S1303 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z434 | MAVS | S165 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z6E9 | RBBP6 | S360 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86UZ6 | ZBTB46 | S294 | ochoa | Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) | Functions as a transcriptional repressor for PRDM1. {ECO:0000250}. |
| Q86XJ1 | GAS2L3 | S307 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86XP3 | DDX42 | S45 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q86YV5 | PRAG1 | S77 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q86Z20 | CCDC125 | S58 | ochoa | Coiled-coil domain-containing protein 125 (Protein kenae) | May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}. |
| Q8IWB9 | TEX2 | S135 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IXQ4 | GPALPP1 | S28 | ochoa | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | None |
| Q8IXQ4 | GPALPP1 | S105 | ochoa | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | None |
| Q8IY33 | MICALL2 | S504 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8NA72 | POC5 | S105 | ochoa | Centrosomal protein POC5 (Protein of centriole 5) (hPOC5) | Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. |
| Q8ND83 | SLAIN1 | S403 | ochoa | SLAIN motif-containing protein 1 | Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}. |
| Q8NDI1 | EHBP1 | S335 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NEA6 | GLIS3 | S545 | ochoa | Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) | Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S2291 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TDC3 | BRSK1 | S443 | ochoa | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. |
| Q8TE68 | EPS8L1 | S239 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TEQ0 | SNX29 | S445 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8WVB3 | HEXD | S466 | ochoa | Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase) | Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221). {ECO:0000269|PubMed:19040401, ECO:0000269|PubMed:23099419, ECO:0000269|PubMed:27149221}. |
| Q8WWI1 | LMO7 | S1539 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92766 | RREB1 | S539 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92835 | INPP5D | S960 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q96BA8 | CREB3L1 | S221 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] | [Cyclic AMP-responsive element-binding protein 3-like protein 1]: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane (PubMed:12054625, PubMed:16417584, PubMed:25310401). In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition (PubMed:12054625, PubMed:21767813, PubMed:25310401). {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125, ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). {ECO:0000269|PubMed:21767813}. |
| Q96D71 | REPS1 | S617 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96EY5 | MVB12A | S80 | ochoa | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96JM2 | ZNF462 | S1611 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96PU4 | UHRF2 | S95 | ochoa | E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) | E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}. |
| Q99081 | TCF12 | S355 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99594 | TEAD3 | S164 | ochoa | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q99624 | SLC38A3 | S52 | ochoa | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}. |
| Q9BRR9 | ARHGAP9 | S203 | ochoa | Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}. |
| Q9BT81 | SOX7 | S28 | ochoa | Transcription factor SOX-7 | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}. |
| Q9BWL3 | C1orf43 | S211 | ochoa | Protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) | General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages. {ECO:0000269|PubMed:31540829}. |
| Q9BZ95 | NSD3 | S129 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9H175 | CSRNP2 | S504 | ochoa | Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. {ECO:0000250}. |
| Q9H1K0 | RBSN | S578 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
| Q9H2D6 | TRIOBP | S1124 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S1176 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2D6 | TRIOBP | S1228 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H3D4 | TP63 | S612 | ochoa | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H869 | YY1AP1 | S455 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9H8X2 | IPPK | S282 | ochoa | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase) | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730, ECO:0000269|PubMed:15967797}. |
| Q9H972 | C14orf93 | S119 | ochoa | Uncharacterized protein C14orf93 | None |
| Q9NPJ4 | PNRC2 | S103 | ochoa | Proline-rich nuclear receptor coactivator 2 | Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250|UniProtKB:Q9CR73, ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429, ECO:0000269|PubMed:25775514}. |
| Q9NSC2 | SALL1 | S1119 | ochoa | Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}. |
| Q9NWS9 | ZNF446 | S181 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NZH5 | PTTG2 | S165 | psp | Securin-2 (Pituitary tumor-transforming gene 2 protein) | None |
| Q9P1Y5 | CAMSAP3 | S585 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P266 | JCAD | S255 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P267 | MBD5 | S264 | ochoa | Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) | Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:36180891). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:36180891}. |
| Q9UF83 | None | S326 | ochoa | Uncharacterized protein DKFZp434B061 | None |
| Q9UGJ0 | PRKAG2 | S87 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
| Q9UGP5 | POLL | S167 | ochoa|psp | DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) | DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}. |
| Q9ULC8 | ZDHHC8 | S526 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULJ7 | ANKRD50 | S1163 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9ULM0 | PLEKHH1 | S263 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9UN79 | SOX13 | S335 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPA5 | BSN | S1477 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPS6 | SETD1B | S1659 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPU9 | SAMD4A | S420 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQ35 | SRRM2 | S1621 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2G1 | MYRF | S294 | ochoa | Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal] | [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269|PubMed:23966832}. |
| Q9Y3L3 | SH3BP1 | S586 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y520 | PRRC2C | S2268 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5B0 | CTDP1 | S740 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9Y6J0 | CABIN1 | S1752 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6Y8 | SEC23IP | S134 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.578591e-07 | 6.589 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.450775e-05 | 4.611 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.450775e-05 | 4.611 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.479996e-04 | 3.349 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.976034e-04 | 3.303 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 7.646238e-04 | 3.117 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.455616e-03 | 2.837 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.434600e-03 | 2.843 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 1.698129e-03 | 2.770 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.595174e-03 | 2.586 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 3.169552e-03 | 2.499 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.483648e-03 | 2.458 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.765123e-03 | 2.239 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.167331e-03 | 2.380 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.961535e-03 | 2.304 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.723603e-03 | 2.326 |
| R-HSA-8848021 | Signaling by PTK6 | 5.763975e-03 | 2.239 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.763975e-03 | 2.239 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 6.532884e-03 | 2.185 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.648650e-03 | 2.177 |
| R-HSA-212436 | Generic Transcription Pathway | 6.865846e-03 | 2.163 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 8.215852e-03 | 2.085 |
| R-HSA-9682385 | FLT3 signaling in disease | 9.342797e-03 | 2.030 |
| R-HSA-1236394 | Signaling by ERBB4 | 9.435330e-03 | 2.025 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.001134e-02 | 2.000 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.131731e-02 | 1.946 |
| R-HSA-9842663 | Signaling by LTK | 1.131731e-02 | 1.946 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.185562e-02 | 1.926 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.413976e-02 | 1.850 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.324365e-02 | 1.878 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 1.413976e-02 | 1.850 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.397096e-02 | 1.855 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.565325e-02 | 1.805 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.565325e-02 | 1.805 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.565325e-02 | 1.805 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.887745e-02 | 1.724 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.887745e-02 | 1.724 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.058530e-02 | 1.686 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.058530e-02 | 1.686 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.933180e-02 | 1.714 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 1.887745e-02 | 1.724 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.058530e-02 | 1.686 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.235511e-02 | 1.651 |
| R-HSA-210993 | Tie2 Signaling | 2.235511e-02 | 1.651 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.248132e-02 | 1.648 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.802268e-02 | 1.552 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.802268e-02 | 1.552 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.002679e-02 | 1.522 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.208619e-02 | 1.494 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.208619e-02 | 1.494 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 4.847365e-02 | 1.314 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 5.788443e-02 | 1.237 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 6.720272e-02 | 1.173 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 6.720272e-02 | 1.173 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 6.720272e-02 | 1.173 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 7.642941e-02 | 1.117 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.642941e-02 | 1.117 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 8.556540e-02 | 1.068 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 8.556540e-02 | 1.068 |
| R-HSA-112412 | SOS-mediated signalling | 9.461158e-02 | 1.024 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.035688e-01 | 0.985 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.035688e-01 | 0.985 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.299156e-01 | 0.886 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.636578e-02 | 1.439 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.470511e-01 | 0.833 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.554927e-01 | 0.808 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.554927e-01 | 0.808 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.794547e-02 | 1.319 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.721275e-01 | 0.764 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.123038e-01 | 0.673 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.123038e-01 | 0.673 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.201034e-01 | 0.657 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.079610e-02 | 1.389 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.354732e-01 | 0.628 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.430448e-01 | 0.614 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.430448e-01 | 0.614 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.653154e-01 | 0.576 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.797995e-01 | 0.553 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.797995e-01 | 0.553 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.869348e-01 | 0.542 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.869348e-01 | 0.542 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 2.869348e-01 | 0.542 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.869348e-01 | 0.542 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 8.593992e-02 | 1.066 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.215710e-01 | 0.493 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.085149e-02 | 1.389 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.995010e-02 | 1.000 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 9.461158e-02 | 1.024 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 5.040291e-02 | 1.298 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.430448e-01 | 0.614 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 2.869348e-01 | 0.542 |
| R-HSA-2424491 | DAP12 signaling | 5.040291e-02 | 1.298 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 1.035688e-01 | 0.985 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.124380e-01 | 0.949 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 2.875361e-01 | 0.541 |
| R-HSA-8849473 | PTK6 Expression | 9.461158e-02 | 1.024 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.325951e-01 | 0.633 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.891851e-01 | 0.723 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.009953e-01 | 0.521 |
| R-HSA-8851805 | MET activates RAS signaling | 1.470511e-01 | 0.833 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.802104e-01 | 0.553 |
| R-HSA-74749 | Signal attenuation | 1.212200e-01 | 0.916 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.470511e-01 | 0.833 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.884367e-01 | 0.725 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.075225e-01 | 0.969 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 5.788443e-02 | 1.237 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.035688e-01 | 0.985 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.212200e-01 | 0.916 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.299156e-01 | 0.886 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.385257e-01 | 0.858 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.385257e-01 | 0.858 |
| R-HSA-428540 | Activation of RAC1 | 1.385257e-01 | 0.858 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.554927e-01 | 0.808 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.721275e-01 | 0.764 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.721275e-01 | 0.764 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.803224e-01 | 0.744 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 2.278263e-01 | 0.642 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 2.354732e-01 | 0.628 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.579652e-01 | 0.588 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.797995e-01 | 0.553 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.939998e-01 | 0.532 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.079218e-01 | 0.512 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.181984e-01 | 0.927 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.794547e-02 | 1.319 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 5.040291e-02 | 1.298 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 6.604389e-02 | 1.180 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.079218e-01 | 0.512 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 6.604389e-02 | 1.180 |
| R-HSA-112399 | IRS-mediated signalling | 1.369718e-01 | 0.863 |
| R-HSA-74751 | Insulin receptor signalling cascade | 1.609494e-01 | 0.793 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.044266e-01 | 0.689 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.123038e-01 | 0.673 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.728795e-01 | 0.564 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.721275e-01 | 0.764 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 9.461158e-02 | 1.024 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 9.461158e-02 | 1.024 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 9.461158e-02 | 1.024 |
| R-HSA-198203 | PI3K/AKT activation | 1.212200e-01 | 0.916 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.470511e-01 | 0.833 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.638512e-01 | 0.786 |
| R-HSA-2172127 | DAP12 interactions | 9.506050e-02 | 1.022 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.579652e-01 | 0.588 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.553243e-01 | 0.593 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.609494e-01 | 0.793 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 7.642941e-02 | 1.117 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.212200e-01 | 0.916 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.638512e-01 | 0.786 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.912231e-02 | 1.309 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.505763e-01 | 0.822 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.939998e-01 | 0.532 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.692130e-01 | 0.570 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.803782e-02 | 1.236 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.644360e-01 | 0.784 |
| R-HSA-202424 | Downstream TCR signaling | 7.675353e-02 | 1.115 |
| R-HSA-190236 | Signaling by FGFR | 2.948540e-01 | 0.530 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.556540e-02 | 1.068 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.085149e-02 | 1.389 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.470511e-01 | 0.833 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.040291e-02 | 1.298 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 1.638512e-01 | 0.786 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.079610e-02 | 1.389 |
| R-HSA-165159 | MTOR signalling | 8.899851e-02 | 1.051 |
| R-HSA-5689603 | UCH proteinases | 2.035474e-01 | 0.691 |
| R-HSA-5654743 | Signaling by FGFR4 | 9.201470e-02 | 1.036 |
| R-HSA-5654741 | Signaling by FGFR3 | 9.813502e-02 | 1.008 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 7.642941e-02 | 1.117 |
| R-HSA-9842640 | Signaling by LTK in cancer | 8.556540e-02 | 1.068 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 9.461158e-02 | 1.024 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.470511e-01 | 0.833 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.470511e-01 | 0.833 |
| R-HSA-186763 | Downstream signal transduction | 5.290485e-02 | 1.277 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.721275e-01 | 0.764 |
| R-HSA-9839394 | TGFBR3 expression | 2.653154e-01 | 0.576 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.794547e-02 | 1.319 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.180276e-01 | 0.661 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.316861e-02 | 1.365 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.357846e-01 | 0.867 |
| R-HSA-9659379 | Sensory processing of sound | 5.664426e-02 | 1.247 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.336155e-01 | 0.874 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.124380e-01 | 0.949 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.123038e-01 | 0.673 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 2.354732e-01 | 0.628 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.430448e-01 | 0.614 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.653154e-01 | 0.576 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.797995e-01 | 0.553 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.869348e-01 | 0.542 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.661725e-01 | 0.779 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 2.430448e-01 | 0.614 |
| R-HSA-74160 | Gene expression (Transcription) | 5.756936e-02 | 1.240 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.720272e-02 | 1.173 |
| R-HSA-448706 | Interleukin-1 processing | 1.124380e-01 | 0.949 |
| R-HSA-9613354 | Lipophagy | 1.124380e-01 | 0.949 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.124380e-01 | 0.949 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.554927e-01 | 0.808 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.721275e-01 | 0.764 |
| R-HSA-167044 | Signalling to RAS | 2.278263e-01 | 0.642 |
| R-HSA-8874211 | CREB3 factors activate genes | 8.556540e-02 | 1.068 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.964712e-01 | 0.707 |
| R-HSA-180292 | GAB1 signalosome | 2.044266e-01 | 0.689 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.044266e-01 | 0.689 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 1.139091e-01 | 0.943 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.505763e-01 | 0.822 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.636578e-02 | 1.439 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 6.604389e-02 | 1.180 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.079218e-01 | 0.512 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 2.797995e-01 | 0.553 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.316861e-02 | 1.365 |
| R-HSA-6806834 | Signaling by MET | 2.180276e-01 | 0.661 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.721275e-01 | 0.764 |
| R-HSA-1433557 | Signaling by SCF-KIT | 9.201470e-02 | 1.036 |
| R-HSA-210990 | PECAM1 interactions | 1.299156e-01 | 0.886 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 7.157354e-02 | 1.145 |
| R-HSA-9620244 | Long-term potentiation | 2.653154e-01 | 0.576 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.336155e-01 | 0.874 |
| R-HSA-525793 | Myogenesis | 2.725933e-01 | 0.564 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.355332e-02 | 1.361 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.288638e-02 | 1.368 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.565630e-01 | 0.805 |
| R-HSA-177929 | Signaling by EGFR | 1.336155e-01 | 0.874 |
| R-HSA-9607240 | FLT3 Signaling | 8.305847e-02 | 1.081 |
| R-HSA-202403 | TCR signaling | 1.225110e-01 | 0.912 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.859945e-02 | 1.164 |
| R-HSA-186797 | Signaling by PDGF | 1.540189e-01 | 0.812 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.638512e-01 | 0.786 |
| R-HSA-8853659 | RET signaling | 6.879016e-02 | 1.162 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.354732e-01 | 0.628 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.336155e-01 | 0.874 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.857158e-02 | 1.232 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.803224e-01 | 0.744 |
| R-HSA-3214842 | HDMs demethylate histones | 2.653154e-01 | 0.576 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.104213e-01 | 0.957 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.176959e-02 | 1.144 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.036109e-01 | 0.518 |
| R-HSA-1632852 | Macroautophagy | 2.083437e-01 | 0.681 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.124380e-01 | 0.949 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.470511e-01 | 0.833 |
| R-HSA-8963896 | HDL assembly | 1.638512e-01 | 0.786 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.884367e-01 | 0.725 |
| R-HSA-166520 | Signaling by NTRKs | 8.475720e-02 | 1.072 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.075225e-01 | 0.969 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.123038e-01 | 0.673 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.009953e-01 | 0.521 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.139445e-01 | 0.943 |
| R-HSA-9612973 | Autophagy | 9.649649e-02 | 1.015 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.472212e-01 | 0.607 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 1.638512e-01 | 0.786 |
| R-HSA-200425 | Carnitine shuttle | 2.505419e-01 | 0.601 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.758026e-01 | 0.755 |
| R-HSA-4839726 | Chromatin organization | 1.314198e-01 | 0.881 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.540189e-01 | 0.812 |
| R-HSA-5620971 | Pyroptosis | 2.869348e-01 | 0.542 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.215710e-01 | 0.493 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.891851e-01 | 0.723 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.342242e-01 | 0.630 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 9.754645e-02 | 1.011 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.820585e-01 | 0.740 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.529092e-02 | 1.257 |
| R-HSA-373753 | Nephrin family interactions | 2.201034e-01 | 0.657 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.653154e-01 | 0.576 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.472069e-01 | 0.832 |
| R-HSA-9830674 | Formation of the ureteric bud | 3.419961e-02 | 1.466 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.505419e-01 | 0.601 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.107747e-01 | 0.676 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.803224e-01 | 0.744 |
| R-HSA-9945266 | Differentiation of T cells | 1.803224e-01 | 0.744 |
| R-HSA-1266738 | Developmental Biology | 2.338524e-01 | 0.631 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.470511e-01 | 0.833 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.927629e-01 | 0.715 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 7.439303e-02 | 1.128 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.094566e-01 | 0.509 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.123038e-01 | 0.673 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.505419e-01 | 0.601 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.426004e-01 | 0.846 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.579652e-01 | 0.588 |
| R-HSA-9830364 | Formation of the nephric duct | 2.653154e-01 | 0.576 |
| R-HSA-73887 | Death Receptor Signaling | 9.349275e-02 | 1.029 |
| R-HSA-354192 | Integrin signaling | 3.215710e-01 | 0.493 |
| R-HSA-9830369 | Kidney development | 3.948426e-02 | 1.404 |
| R-HSA-622312 | Inflammasomes | 2.869348e-01 | 0.542 |
| R-HSA-1483255 | PI Metabolism | 3.094566e-01 | 0.509 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.036109e-01 | 0.518 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.216625e-01 | 0.654 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.215710e-01 | 0.493 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.282949e-01 | 0.484 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.312424e-01 | 0.480 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.312424e-01 | 0.480 |
| R-HSA-422475 | Axon guidance | 3.324192e-01 | 0.478 |
| R-HSA-187687 | Signalling to ERKs | 3.415447e-01 | 0.467 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.415447e-01 | 0.467 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.480719e-01 | 0.458 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.480719e-01 | 0.458 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.480719e-01 | 0.458 |
| R-HSA-9679506 | SARS-CoV Infections | 3.484961e-01 | 0.458 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.492526e-01 | 0.457 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.492526e-01 | 0.457 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.492526e-01 | 0.457 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.545348e-01 | 0.450 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 3.545348e-01 | 0.450 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.545348e-01 | 0.450 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.635445e-01 | 0.439 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.670995e-01 | 0.435 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.672702e-01 | 0.435 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.672702e-01 | 0.435 |
| R-HSA-201556 | Signaling by ALK | 3.672702e-01 | 0.435 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.686457e-01 | 0.433 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.735439e-01 | 0.428 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.735439e-01 | 0.428 |
| R-HSA-167169 | HIV Transcription Elongation | 3.735439e-01 | 0.428 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.735439e-01 | 0.428 |
| R-HSA-5260271 | Diseases of Immune System | 3.735439e-01 | 0.428 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.735439e-01 | 0.428 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.792213e-01 | 0.421 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.797558e-01 | 0.420 |
| R-HSA-9694548 | Maturation of spike protein | 3.797558e-01 | 0.420 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.821146e-01 | 0.418 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.843571e-01 | 0.415 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.859065e-01 | 0.414 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 3.919966e-01 | 0.407 |
| R-HSA-9675108 | Nervous system development | 3.922747e-01 | 0.406 |
| R-HSA-8854214 | TBC/RABGAPs | 3.980266e-01 | 0.400 |
| R-HSA-373752 | Netrin-1 signaling | 4.039972e-01 | 0.394 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.039972e-01 | 0.394 |
| R-HSA-194138 | Signaling by VEGF | 4.056622e-01 | 0.392 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.099090e-01 | 0.387 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.099090e-01 | 0.387 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.157625e-01 | 0.381 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.157625e-01 | 0.381 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.157625e-01 | 0.381 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.157625e-01 | 0.381 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.215582e-01 | 0.375 |
| R-HSA-1474165 | Reproduction | 4.262252e-01 | 0.370 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.272969e-01 | 0.369 |
| R-HSA-109704 | PI3K Cascade | 4.386050e-01 | 0.358 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.426268e-01 | 0.354 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.441755e-01 | 0.352 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.496912e-01 | 0.347 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.496912e-01 | 0.347 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.496912e-01 | 0.347 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.497423e-01 | 0.347 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.551524e-01 | 0.342 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.551524e-01 | 0.342 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.551524e-01 | 0.342 |
| R-HSA-8939211 | ESR-mediated signaling | 4.709798e-01 | 0.327 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 4.709798e-01 | 0.327 |
| R-HSA-75893 | TNF signaling | 4.712150e-01 | 0.327 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.712150e-01 | 0.327 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.727115e-01 | 0.325 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.759461e-01 | 0.322 |
| R-HSA-1483166 | Synthesis of PA | 4.764639e-01 | 0.322 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.855552e-01 | 0.314 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.868070e-01 | 0.313 |
| R-HSA-983189 | Kinesins | 4.919021e-01 | 0.308 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.919021e-01 | 0.308 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.962008e-01 | 0.304 |
| R-HSA-199991 | Membrane Trafficking | 4.986513e-01 | 0.302 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.019420e-01 | 0.299 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.019420e-01 | 0.299 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.019420e-01 | 0.299 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.076226e-01 | 0.294 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.107218e-01 | 0.292 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.117847e-01 | 0.291 |
| R-HSA-5688426 | Deubiquitination | 5.158136e-01 | 0.288 |
| R-HSA-162587 | HIV Life Cycle | 5.199430e-01 | 0.284 |
| R-HSA-9711097 | Cellular response to starvation | 5.229911e-01 | 0.282 |
| R-HSA-877300 | Interferon gamma signaling | 5.260263e-01 | 0.279 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.261875e-01 | 0.279 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.290486e-01 | 0.277 |
| R-HSA-167172 | Transcription of the HIV genome | 5.308939e-01 | 0.275 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.308939e-01 | 0.275 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 5.308939e-01 | 0.275 |
| R-HSA-5218859 | Regulated Necrosis | 5.308939e-01 | 0.275 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.350883e-01 | 0.272 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.401679e-01 | 0.267 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.401679e-01 | 0.267 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.401679e-01 | 0.267 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.492597e-01 | 0.260 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.492597e-01 | 0.260 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.537384e-01 | 0.257 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.581729e-01 | 0.253 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.625635e-01 | 0.250 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.712152e-01 | 0.243 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.728064e-01 | 0.242 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.754770e-01 | 0.240 |
| R-HSA-9833482 | PKR-mediated signaling | 5.838748e-01 | 0.234 |
| R-HSA-2559583 | Cellular Senescence | 5.894706e-01 | 0.230 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.921075e-01 | 0.228 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.976214e-01 | 0.224 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.001783e-01 | 0.222 |
| R-HSA-1483257 | Phospholipid metabolism | 6.076555e-01 | 0.216 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.080904e-01 | 0.216 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.080904e-01 | 0.216 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.080904e-01 | 0.216 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.119879e-01 | 0.213 |
| R-HSA-168898 | Toll-like Receptor Cascades | 6.187653e-01 | 0.208 |
| R-HSA-156902 | Peptide chain elongation | 6.196678e-01 | 0.208 |
| R-HSA-9663891 | Selective autophagy | 6.196678e-01 | 0.208 |
| R-HSA-1280218 | Adaptive Immune System | 6.211639e-01 | 0.207 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.213479e-01 | 0.207 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.264729e-01 | 0.203 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.309052e-01 | 0.200 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.309052e-01 | 0.200 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.345771e-01 | 0.198 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.382128e-01 | 0.195 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.382128e-01 | 0.195 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.382128e-01 | 0.195 |
| R-HSA-1474290 | Collagen formation | 6.453767e-01 | 0.190 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.489056e-01 | 0.188 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.523996e-01 | 0.185 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.523996e-01 | 0.185 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.523996e-01 | 0.185 |
| R-HSA-72172 | mRNA Splicing | 6.537069e-01 | 0.185 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.558590e-01 | 0.183 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.558590e-01 | 0.183 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.558590e-01 | 0.183 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.589087e-01 | 0.181 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.626756e-01 | 0.179 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.626756e-01 | 0.179 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.626756e-01 | 0.179 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.660334e-01 | 0.177 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.693579e-01 | 0.174 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.725103e-01 | 0.172 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.726496e-01 | 0.172 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.726496e-01 | 0.172 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.726496e-01 | 0.172 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.759087e-01 | 0.170 |
| R-HSA-192823 | Viral mRNA Translation | 6.791356e-01 | 0.168 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.823305e-01 | 0.166 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.823305e-01 | 0.166 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.823305e-01 | 0.166 |
| R-HSA-9833110 | RSV-host interactions | 6.854939e-01 | 0.164 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.886259e-01 | 0.162 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.886259e-01 | 0.162 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.947972e-01 | 0.158 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.978372e-01 | 0.156 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.978372e-01 | 0.156 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.978372e-01 | 0.156 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.008470e-01 | 0.154 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.008470e-01 | 0.154 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.038271e-01 | 0.153 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.038271e-01 | 0.153 |
| R-HSA-162906 | HIV Infection | 7.055422e-01 | 0.151 |
| R-HSA-162582 | Signal Transduction | 7.086270e-01 | 0.150 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.096989e-01 | 0.149 |
| R-HSA-9824446 | Viral Infection Pathways | 7.108862e-01 | 0.148 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.125914e-01 | 0.147 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.125914e-01 | 0.147 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.143356e-01 | 0.146 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.154551e-01 | 0.145 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.214993e-01 | 0.142 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.238774e-01 | 0.140 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.238774e-01 | 0.140 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.266294e-01 | 0.139 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.266294e-01 | 0.139 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.293541e-01 | 0.137 |
| R-HSA-73894 | DNA Repair | 7.306149e-01 | 0.136 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.347229e-01 | 0.134 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.347229e-01 | 0.134 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.354871e-01 | 0.133 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.399859e-01 | 0.131 |
| R-HSA-3371556 | Cellular response to heat stress | 7.399859e-01 | 0.131 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.399859e-01 | 0.131 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.425783e-01 | 0.129 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.425783e-01 | 0.129 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.526936e-01 | 0.123 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.526936e-01 | 0.123 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.526936e-01 | 0.123 |
| R-HSA-913531 | Interferon Signaling | 7.676786e-01 | 0.115 |
| R-HSA-9843745 | Adipogenesis | 7.694540e-01 | 0.114 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.717544e-01 | 0.113 |
| R-HSA-449147 | Signaling by Interleukins | 7.727904e-01 | 0.112 |
| R-HSA-416476 | G alpha (q) signalling events | 7.753284e-01 | 0.111 |
| R-HSA-163685 | Integration of energy metabolism | 7.829183e-01 | 0.106 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.850852e-01 | 0.105 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.872305e-01 | 0.104 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.893545e-01 | 0.103 |
| R-HSA-9664407 | Parasite infection | 7.914574e-01 | 0.102 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.914574e-01 | 0.102 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.914574e-01 | 0.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.915456e-01 | 0.102 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.935395e-01 | 0.100 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.976419e-01 | 0.098 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.992632e-01 | 0.097 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.016633e-01 | 0.096 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.022792e-01 | 0.096 |
| R-HSA-9658195 | Leishmania infection | 8.022792e-01 | 0.096 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.037722e-01 | 0.095 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.075470e-01 | 0.093 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 8.094694e-01 | 0.092 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.151229e-01 | 0.089 |
| R-HSA-109582 | Hemostasis | 8.156383e-01 | 0.089 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.169701e-01 | 0.088 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.169701e-01 | 0.088 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.206096e-01 | 0.086 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.224023e-01 | 0.085 |
| R-HSA-9610379 | HCMV Late Events | 8.259345e-01 | 0.083 |
| R-HSA-195721 | Signaling by WNT | 8.263398e-01 | 0.083 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.311023e-01 | 0.080 |
| R-HSA-109581 | Apoptosis | 8.344625e-01 | 0.079 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.377563e-01 | 0.077 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.377563e-01 | 0.077 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.487798e-01 | 0.071 |
| R-HSA-1500931 | Cell-Cell communication | 8.489334e-01 | 0.071 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.502926e-01 | 0.070 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.532733e-01 | 0.069 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.532733e-01 | 0.069 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.569784e-01 | 0.067 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.569784e-01 | 0.067 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.579957e-01 | 0.067 |
| R-HSA-168255 | Influenza Infection | 8.618659e-01 | 0.065 |
| R-HSA-69275 | G2/M Transition | 8.712605e-01 | 0.060 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.738260e-01 | 0.059 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.738260e-01 | 0.059 |
| R-HSA-68877 | Mitotic Prometaphase | 8.800198e-01 | 0.056 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.835638e-01 | 0.054 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.835900e-01 | 0.054 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.881866e-01 | 0.051 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.904168e-01 | 0.050 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.915153e-01 | 0.050 |
| R-HSA-5357801 | Programmed Cell Death | 8.947455e-01 | 0.048 |
| R-HSA-2262752 | Cellular responses to stress | 8.967989e-01 | 0.047 |
| R-HSA-68882 | Mitotic Anaphase | 9.057927e-01 | 0.043 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.067379e-01 | 0.043 |
| R-HSA-418990 | Adherens junctions interactions | 9.076737e-01 | 0.042 |
| R-HSA-8951664 | Neddylation | 9.104255e-01 | 0.041 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.122017e-01 | 0.040 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.165334e-01 | 0.038 |
| R-HSA-72312 | rRNA processing | 9.198359e-01 | 0.036 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.217024e-01 | 0.035 |
| R-HSA-157118 | Signaling by NOTCH | 9.260564e-01 | 0.033 |
| R-HSA-8953854 | Metabolism of RNA | 9.311768e-01 | 0.031 |
| R-HSA-9609646 | HCMV Infection | 9.331615e-01 | 0.030 |
| R-HSA-421270 | Cell-cell junction organization | 9.338335e-01 | 0.030 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.383535e-01 | 0.028 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.442834e-01 | 0.025 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.487748e-01 | 0.023 |
| R-HSA-446728 | Cell junction organization | 9.496461e-01 | 0.022 |
| R-HSA-112316 | Neuronal System | 9.567367e-01 | 0.019 |
| R-HSA-5663205 | Infectious disease | 9.596125e-01 | 0.018 |
| R-HSA-168249 | Innate Immune System | 9.627402e-01 | 0.016 |
| R-HSA-1474244 | Extracellular matrix organization | 9.705812e-01 | 0.013 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.814623e-01 | 0.008 |
| R-HSA-68886 | M Phase | 9.826676e-01 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 9.865686e-01 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 9.867713e-01 | 0.006 |
| R-HSA-168256 | Immune System | 9.875036e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.884762e-01 | 0.005 |
| R-HSA-72766 | Translation | 9.892718e-01 | 0.005 |
| R-HSA-1643685 | Disease | 9.908802e-01 | 0.004 |
| R-HSA-6798695 | Neutrophil degranulation | 9.919440e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.933246e-01 | 0.003 |
| R-HSA-1640170 | Cell Cycle | 9.948162e-01 | 0.002 |
| R-HSA-597592 | Post-translational protein modification | 9.953154e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.976778e-01 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.984639e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.997641e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.998699e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.999470e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.843 | 0.730 | 1 | 0.802 |
CDK18 |
0.838 | 0.781 | 1 | 0.864 |
HIPK2 |
0.838 | 0.737 | 1 | 0.842 |
CDK17 |
0.835 | 0.787 | 1 | 0.888 |
CDK19 |
0.831 | 0.758 | 1 | 0.850 |
CDK7 |
0.831 | 0.769 | 1 | 0.826 |
P38G |
0.830 | 0.799 | 1 | 0.897 |
CDK13 |
0.825 | 0.765 | 1 | 0.845 |
CDK8 |
0.825 | 0.753 | 1 | 0.823 |
JNK2 |
0.825 | 0.799 | 1 | 0.862 |
CDK12 |
0.824 | 0.768 | 1 | 0.863 |
CDK1 |
0.824 | 0.748 | 1 | 0.852 |
CDK16 |
0.823 | 0.746 | 1 | 0.876 |
CDK3 |
0.822 | 0.673 | 1 | 0.884 |
DYRK2 |
0.821 | 0.707 | 1 | 0.767 |
P38D |
0.820 | 0.778 | 1 | 0.888 |
CDK5 |
0.820 | 0.724 | 1 | 0.800 |
ERK1 |
0.819 | 0.759 | 1 | 0.845 |
P38B |
0.819 | 0.769 | 1 | 0.834 |
CDK10 |
0.818 | 0.713 | 1 | 0.842 |
CLK3 |
0.817 | 0.485 | 1 | 0.561 |
HIPK4 |
0.817 | 0.520 | 1 | 0.571 |
DYRK4 |
0.817 | 0.710 | 1 | 0.856 |
CDK14 |
0.817 | 0.745 | 1 | 0.827 |
CDK9 |
0.815 | 0.743 | 1 | 0.838 |
HIPK1 |
0.815 | 0.667 | 1 | 0.751 |
JNK3 |
0.814 | 0.780 | 1 | 0.844 |
DYRK1B |
0.814 | 0.693 | 1 | 0.822 |
P38A |
0.808 | 0.739 | 1 | 0.771 |
DYRK1A |
0.807 | 0.595 | 1 | 0.742 |
SRPK1 |
0.805 | 0.362 | -3 | 0.735 |
HIPK3 |
0.804 | 0.646 | 1 | 0.722 |
NLK |
0.804 | 0.674 | 1 | 0.583 |
ERK2 |
0.801 | 0.733 | 1 | 0.808 |
CDK4 |
0.801 | 0.735 | 1 | 0.866 |
CDK6 |
0.799 | 0.709 | 1 | 0.842 |
CLK2 |
0.796 | 0.410 | -3 | 0.722 |
JNK1 |
0.795 | 0.698 | 1 | 0.866 |
DYRK3 |
0.794 | 0.525 | 1 | 0.714 |
CLK1 |
0.793 | 0.404 | -3 | 0.706 |
SRPK2 |
0.793 | 0.293 | -3 | 0.661 |
MAK |
0.792 | 0.511 | -2 | 0.826 |
ICK |
0.789 | 0.381 | -3 | 0.804 |
ERK5 |
0.788 | 0.358 | 1 | 0.498 |
CDK2 |
0.788 | 0.542 | 1 | 0.738 |
CLK4 |
0.788 | 0.368 | -3 | 0.728 |
CDKL5 |
0.786 | 0.201 | -3 | 0.770 |
MTOR |
0.782 | 0.204 | 1 | 0.379 |
PRP4 |
0.782 | 0.476 | -3 | 0.787 |
COT |
0.780 | -0.048 | 2 | 0.681 |
SRPK3 |
0.780 | 0.261 | -3 | 0.701 |
CDKL1 |
0.779 | 0.173 | -3 | 0.773 |
MOK |
0.777 | 0.470 | 1 | 0.642 |
MOS |
0.777 | 0.090 | 1 | 0.270 |
CDC7 |
0.774 | -0.045 | 1 | 0.234 |
CHAK2 |
0.770 | 0.043 | -1 | 0.759 |
NDR2 |
0.769 | -0.013 | -3 | 0.782 |
TBK1 |
0.766 | -0.142 | 1 | 0.177 |
PRPK |
0.766 | -0.083 | -1 | 0.753 |
PIM3 |
0.766 | -0.019 | -3 | 0.794 |
ERK7 |
0.765 | 0.242 | 2 | 0.445 |
GCN2 |
0.763 | -0.188 | 2 | 0.651 |
ATR |
0.763 | -0.038 | 1 | 0.249 |
WNK1 |
0.762 | -0.062 | -2 | 0.888 |
MST4 |
0.762 | -0.032 | 2 | 0.695 |
IKKE |
0.762 | -0.150 | 1 | 0.179 |
SKMLCK |
0.762 | -0.024 | -2 | 0.882 |
CAMK1B |
0.761 | -0.023 | -3 | 0.804 |
PRKD1 |
0.761 | 0.004 | -3 | 0.791 |
PKN3 |
0.761 | -0.038 | -3 | 0.777 |
NEK6 |
0.760 | -0.068 | -2 | 0.839 |
AURC |
0.760 | 0.033 | -2 | 0.677 |
NDR1 |
0.760 | -0.042 | -3 | 0.777 |
NUAK2 |
0.760 | 0.006 | -3 | 0.784 |
RAF1 |
0.759 | -0.169 | 1 | 0.207 |
ULK2 |
0.759 | -0.185 | 2 | 0.644 |
TGFBR2 |
0.759 | -0.079 | -2 | 0.785 |
RIPK3 |
0.758 | -0.102 | 3 | 0.752 |
RSK2 |
0.758 | -0.003 | -3 | 0.745 |
GRK1 |
0.758 | 0.014 | -2 | 0.805 |
PRKD2 |
0.758 | 0.019 | -3 | 0.735 |
BMPR2 |
0.758 | -0.158 | -2 | 0.860 |
CAMLCK |
0.758 | 0.001 | -2 | 0.847 |
GSK3A |
0.757 | 0.227 | 4 | 0.519 |
AMPKA1 |
0.757 | -0.029 | -3 | 0.789 |
P90RSK |
0.757 | -0.004 | -3 | 0.754 |
NIK |
0.757 | -0.058 | -3 | 0.812 |
PDHK4 |
0.757 | -0.191 | 1 | 0.272 |
PKN2 |
0.756 | -0.057 | -3 | 0.772 |
RSK3 |
0.756 | -0.015 | -3 | 0.735 |
PKCD |
0.756 | -0.038 | 2 | 0.626 |
PKACG |
0.755 | -0.015 | -2 | 0.770 |
NEK7 |
0.755 | -0.156 | -3 | 0.791 |
IKKB |
0.755 | -0.163 | -2 | 0.715 |
DAPK2 |
0.754 | -0.020 | -3 | 0.812 |
DSTYK |
0.754 | -0.158 | 2 | 0.686 |
MARK4 |
0.754 | -0.057 | 4 | 0.806 |
IRE1 |
0.754 | -0.085 | 1 | 0.198 |
AMPKA2 |
0.753 | -0.015 | -3 | 0.761 |
CAMK2G |
0.753 | -0.109 | 2 | 0.626 |
PIM1 |
0.753 | 0.011 | -3 | 0.739 |
MLK2 |
0.753 | -0.094 | 2 | 0.662 |
MLK1 |
0.752 | -0.148 | 2 | 0.641 |
PHKG1 |
0.752 | -0.053 | -3 | 0.769 |
LATS2 |
0.751 | -0.054 | -5 | 0.795 |
LATS1 |
0.751 | 0.011 | -3 | 0.798 |
ULK1 |
0.750 | -0.178 | -3 | 0.755 |
MNK2 |
0.750 | -0.038 | -2 | 0.799 |
MLK3 |
0.750 | -0.067 | 2 | 0.580 |
MAPKAPK3 |
0.750 | -0.048 | -3 | 0.730 |
PDHK1 |
0.750 | -0.206 | 1 | 0.246 |
IRE2 |
0.749 | -0.078 | 2 | 0.623 |
WNK3 |
0.749 | -0.197 | 1 | 0.202 |
P70S6KB |
0.749 | -0.016 | -3 | 0.747 |
TSSK1 |
0.749 | -0.052 | -3 | 0.812 |
GRK7 |
0.749 | 0.008 | 1 | 0.239 |
NIM1 |
0.749 | -0.091 | 3 | 0.761 |
PKCB |
0.749 | -0.043 | 2 | 0.574 |
MASTL |
0.748 | -0.161 | -2 | 0.816 |
BMPR1B |
0.748 | -0.032 | 1 | 0.207 |
GRK5 |
0.748 | -0.159 | -3 | 0.776 |
PKCZ |
0.748 | -0.048 | 2 | 0.632 |
RIPK1 |
0.748 | -0.157 | 1 | 0.196 |
PRKD3 |
0.747 | 0.004 | -3 | 0.705 |
PKCG |
0.747 | -0.047 | 2 | 0.576 |
PKCA |
0.747 | -0.033 | 2 | 0.580 |
HUNK |
0.747 | -0.172 | 2 | 0.664 |
PKG2 |
0.746 | 0.003 | -2 | 0.700 |
PAK3 |
0.746 | -0.067 | -2 | 0.785 |
NEK9 |
0.746 | -0.183 | 2 | 0.682 |
NUAK1 |
0.746 | -0.039 | -3 | 0.730 |
MELK |
0.745 | -0.067 | -3 | 0.750 |
QSK |
0.745 | -0.022 | 4 | 0.793 |
PAK1 |
0.745 | -0.050 | -2 | 0.794 |
AURB |
0.745 | -0.004 | -2 | 0.668 |
MNK1 |
0.745 | -0.033 | -2 | 0.809 |
PKACB |
0.745 | 0.022 | -2 | 0.695 |
AKT2 |
0.745 | 0.037 | -3 | 0.661 |
MAPKAPK2 |
0.745 | -0.031 | -3 | 0.697 |
TGFBR1 |
0.745 | -0.042 | -2 | 0.790 |
CAMK2D |
0.744 | -0.116 | -3 | 0.786 |
IKKA |
0.744 | -0.113 | -2 | 0.711 |
MPSK1 |
0.744 | 0.056 | 1 | 0.256 |
RSK4 |
0.744 | -0.000 | -3 | 0.718 |
ALK4 |
0.744 | -0.053 | -2 | 0.814 |
PAK6 |
0.743 | -0.024 | -2 | 0.692 |
ANKRD3 |
0.743 | -0.162 | 1 | 0.222 |
VRK2 |
0.743 | 0.036 | 1 | 0.307 |
TSSK2 |
0.743 | -0.097 | -5 | 0.853 |
CHAK1 |
0.742 | -0.104 | 2 | 0.679 |
GSK3B |
0.742 | 0.091 | 4 | 0.516 |
ATM |
0.742 | -0.086 | 1 | 0.212 |
SGK3 |
0.742 | -0.007 | -3 | 0.712 |
PINK1 |
0.742 | 0.139 | 1 | 0.408 |
SIK |
0.742 | -0.032 | -3 | 0.703 |
MSK2 |
0.742 | -0.044 | -3 | 0.712 |
DLK |
0.741 | -0.199 | 1 | 0.225 |
DNAPK |
0.741 | -0.054 | 1 | 0.213 |
PRKX |
0.741 | 0.043 | -3 | 0.638 |
QIK |
0.741 | -0.094 | -3 | 0.768 |
CAMK4 |
0.740 | -0.117 | -3 | 0.749 |
BCKDK |
0.739 | -0.191 | -1 | 0.658 |
SMG1 |
0.739 | -0.070 | 1 | 0.226 |
PKCH |
0.739 | -0.080 | 2 | 0.571 |
PKR |
0.739 | -0.106 | 1 | 0.223 |
NEK2 |
0.739 | -0.126 | 2 | 0.675 |
ACVR2B |
0.739 | -0.054 | -2 | 0.778 |
MLK4 |
0.739 | -0.116 | 2 | 0.562 |
TTBK2 |
0.739 | -0.196 | 2 | 0.564 |
PLK4 |
0.738 | -0.126 | 2 | 0.507 |
YSK4 |
0.738 | -0.161 | 1 | 0.191 |
FAM20C |
0.738 | -0.053 | 2 | 0.449 |
CAMK2A |
0.738 | -0.048 | 2 | 0.604 |
MSK1 |
0.737 | -0.023 | -3 | 0.708 |
GRK6 |
0.737 | -0.162 | 1 | 0.214 |
DCAMKL1 |
0.737 | -0.049 | -3 | 0.735 |
MYLK4 |
0.736 | -0.035 | -2 | 0.779 |
BRSK2 |
0.736 | -0.090 | -3 | 0.751 |
PIM2 |
0.736 | 0.015 | -3 | 0.708 |
MEK1 |
0.736 | -0.149 | 2 | 0.683 |
GRK4 |
0.735 | -0.178 | -2 | 0.822 |
MARK3 |
0.735 | -0.039 | 4 | 0.754 |
PAK2 |
0.735 | -0.080 | -2 | 0.775 |
PLK1 |
0.735 | -0.146 | -2 | 0.773 |
ACVR2A |
0.735 | -0.084 | -2 | 0.763 |
MST3 |
0.735 | -0.049 | 2 | 0.680 |
PKCT |
0.734 | -0.066 | 2 | 0.578 |
IRAK4 |
0.733 | -0.121 | 1 | 0.182 |
WNK4 |
0.733 | -0.112 | -2 | 0.879 |
BRSK1 |
0.733 | -0.073 | -3 | 0.736 |
PKCI |
0.733 | -0.037 | 2 | 0.606 |
CAMK2B |
0.733 | -0.097 | 2 | 0.582 |
CK1E |
0.732 | -0.016 | -3 | 0.498 |
TLK2 |
0.732 | -0.132 | 1 | 0.187 |
CAMK1G |
0.732 | -0.055 | -3 | 0.718 |
AKT1 |
0.732 | 0.007 | -3 | 0.673 |
MARK2 |
0.732 | -0.057 | 4 | 0.724 |
AURA |
0.731 | -0.035 | -2 | 0.632 |
SNRK |
0.731 | -0.151 | 2 | 0.543 |
DCAMKL2 |
0.731 | -0.062 | -3 | 0.754 |
PAK4 |
0.730 | -0.026 | -2 | 0.654 |
MEK5 |
0.730 | -0.152 | 2 | 0.665 |
SSTK |
0.730 | -0.054 | 4 | 0.778 |
PAK5 |
0.730 | -0.037 | -2 | 0.650 |
TAO3 |
0.730 | -0.052 | 1 | 0.237 |
ALK2 |
0.730 | -0.087 | -2 | 0.794 |
PKACA |
0.729 | 0.006 | -2 | 0.646 |
MAPKAPK5 |
0.729 | -0.082 | -3 | 0.688 |
DRAK1 |
0.729 | -0.150 | 1 | 0.193 |
PASK |
0.729 | -0.027 | -3 | 0.806 |
MEKK2 |
0.728 | -0.132 | 2 | 0.645 |
BMPR1A |
0.728 | -0.057 | 1 | 0.197 |
PERK |
0.728 | -0.164 | -2 | 0.816 |
PKCE |
0.728 | -0.016 | 2 | 0.578 |
MEKK1 |
0.728 | -0.161 | 1 | 0.210 |
GRK2 |
0.728 | -0.093 | -2 | 0.705 |
ZAK |
0.727 | -0.178 | 1 | 0.202 |
NEK5 |
0.727 | -0.141 | 1 | 0.197 |
CHK1 |
0.727 | -0.095 | -3 | 0.754 |
PHKG2 |
0.726 | -0.099 | -3 | 0.731 |
HRI |
0.725 | -0.177 | -2 | 0.830 |
PKN1 |
0.725 | -0.033 | -3 | 0.685 |
AKT3 |
0.725 | 0.027 | -3 | 0.614 |
CK1D |
0.725 | 0.006 | -3 | 0.448 |
SMMLCK |
0.725 | -0.038 | -3 | 0.767 |
PDK1 |
0.725 | -0.050 | 1 | 0.246 |
BUB1 |
0.724 | 0.044 | -5 | 0.783 |
HASPIN |
0.724 | 0.042 | -1 | 0.655 |
MEKK3 |
0.724 | -0.177 | 1 | 0.211 |
NEK11 |
0.724 | -0.119 | 1 | 0.229 |
MARK1 |
0.723 | -0.092 | 4 | 0.759 |
P70S6K |
0.722 | -0.041 | -3 | 0.666 |
MAP3K15 |
0.722 | -0.086 | 1 | 0.210 |
LKB1 |
0.722 | -0.027 | -3 | 0.783 |
SGK1 |
0.721 | 0.039 | -3 | 0.592 |
PLK3 |
0.721 | -0.169 | 2 | 0.590 |
CK1A2 |
0.721 | -0.016 | -3 | 0.448 |
TLK1 |
0.721 | -0.158 | -2 | 0.817 |
GAK |
0.721 | -0.043 | 1 | 0.257 |
GCK |
0.721 | -0.064 | 1 | 0.212 |
BRAF |
0.720 | -0.168 | -4 | 0.825 |
TAO2 |
0.720 | -0.078 | 2 | 0.686 |
SBK |
0.719 | 0.106 | -3 | 0.561 |
HPK1 |
0.719 | -0.055 | 1 | 0.213 |
HGK |
0.719 | -0.070 | 3 | 0.881 |
NEK8 |
0.718 | -0.168 | 2 | 0.662 |
MEKK6 |
0.718 | -0.112 | 1 | 0.211 |
PBK |
0.718 | -0.022 | 1 | 0.228 |
KHS1 |
0.716 | -0.037 | 1 | 0.201 |
DAPK3 |
0.716 | -0.037 | -3 | 0.750 |
MINK |
0.716 | -0.103 | 1 | 0.187 |
ROCK2 |
0.716 | -0.005 | -3 | 0.733 |
LRRK2 |
0.716 | -0.040 | 2 | 0.691 |
NEK4 |
0.716 | -0.148 | 1 | 0.180 |
LOK |
0.715 | -0.073 | -2 | 0.779 |
TNIK |
0.715 | -0.058 | 3 | 0.870 |
TTBK1 |
0.715 | -0.181 | 2 | 0.497 |
MRCKB |
0.715 | -0.003 | -3 | 0.685 |
CK1G1 |
0.715 | -0.085 | -3 | 0.486 |
CHK2 |
0.715 | -0.014 | -3 | 0.611 |
KHS2 |
0.715 | -0.015 | 1 | 0.214 |
CAMK1D |
0.714 | -0.053 | -3 | 0.643 |
GRK3 |
0.713 | -0.095 | -2 | 0.668 |
MST2 |
0.712 | -0.145 | 1 | 0.197 |
CK2A2 |
0.712 | -0.075 | 1 | 0.188 |
MRCKA |
0.712 | -0.018 | -3 | 0.699 |
EEF2K |
0.712 | -0.092 | 3 | 0.826 |
IRAK1 |
0.712 | -0.221 | -1 | 0.662 |
DAPK1 |
0.711 | -0.037 | -3 | 0.735 |
SLK |
0.710 | -0.072 | -2 | 0.736 |
CAMKK2 |
0.710 | -0.154 | -2 | 0.717 |
NEK1 |
0.710 | -0.144 | 1 | 0.181 |
STK33 |
0.710 | -0.126 | 2 | 0.486 |
VRK1 |
0.709 | -0.159 | 2 | 0.691 |
DMPK1 |
0.709 | 0.024 | -3 | 0.712 |
CAMKK1 |
0.707 | -0.224 | -2 | 0.709 |
PDHK3_TYR |
0.707 | 0.187 | 4 | 0.828 |
PKG1 |
0.707 | -0.026 | -2 | 0.615 |
CAMK1A |
0.707 | -0.034 | -3 | 0.622 |
TAK1 |
0.706 | -0.173 | 1 | 0.191 |
YSK1 |
0.706 | -0.125 | 2 | 0.660 |
CK2A1 |
0.705 | -0.075 | 1 | 0.182 |
NEK3 |
0.705 | -0.116 | 1 | 0.205 |
CRIK |
0.704 | 0.017 | -3 | 0.678 |
LIMK2_TYR |
0.704 | 0.162 | -3 | 0.831 |
RIPK2 |
0.703 | -0.212 | 1 | 0.180 |
MST1 |
0.703 | -0.162 | 1 | 0.188 |
ROCK1 |
0.701 | -0.022 | -3 | 0.700 |
MEK2 |
0.699 | -0.213 | 2 | 0.667 |
TESK1_TYR |
0.698 | 0.070 | 3 | 0.857 |
PKMYT1_TYR |
0.697 | 0.125 | 3 | 0.831 |
MYO3B |
0.696 | -0.073 | 2 | 0.685 |
OSR1 |
0.696 | -0.098 | 2 | 0.651 |
TTK |
0.696 | -0.095 | -2 | 0.805 |
PLK2 |
0.696 | -0.112 | -3 | 0.717 |
BIKE |
0.696 | -0.049 | 1 | 0.231 |
PDHK4_TYR |
0.695 | 0.076 | 2 | 0.701 |
ASK1 |
0.695 | -0.128 | 1 | 0.211 |
TAO1 |
0.695 | -0.097 | 1 | 0.199 |
BMPR2_TYR |
0.694 | 0.096 | -1 | 0.825 |
MAP2K4_TYR |
0.694 | 0.044 | -1 | 0.767 |
MYO3A |
0.692 | -0.098 | 1 | 0.202 |
MAP2K6_TYR |
0.691 | 0.031 | -1 | 0.787 |
AAK1 |
0.691 | -0.014 | 1 | 0.227 |
PDHK1_TYR |
0.690 | 0.014 | -1 | 0.802 |
MAP2K7_TYR |
0.690 | -0.071 | 2 | 0.691 |
YANK3 |
0.689 | -0.073 | 2 | 0.301 |
ALPHAK3 |
0.687 | -0.086 | -1 | 0.693 |
CK1A |
0.686 | -0.041 | -3 | 0.364 |
LIMK1_TYR |
0.686 | -0.012 | 2 | 0.702 |
PINK1_TYR |
0.686 | -0.110 | 1 | 0.267 |
EPHA6 |
0.684 | -0.032 | -1 | 0.792 |
MST1R |
0.684 | -0.062 | 3 | 0.815 |
JAK3 |
0.683 | -0.049 | 1 | 0.227 |
RET |
0.682 | -0.124 | 1 | 0.227 |
TXK |
0.681 | -0.033 | 1 | 0.199 |
JAK2 |
0.681 | -0.092 | 1 | 0.235 |
CSF1R |
0.681 | -0.076 | 3 | 0.807 |
EPHB4 |
0.681 | -0.077 | -1 | 0.738 |
NEK10_TYR |
0.681 | -0.063 | 1 | 0.208 |
TNK2 |
0.680 | -0.057 | 3 | 0.772 |
LCK |
0.680 | 0.002 | -1 | 0.778 |
ROS1 |
0.680 | -0.110 | 3 | 0.796 |
JAK1 |
0.679 | -0.048 | 1 | 0.200 |
BLK |
0.677 | -0.002 | -1 | 0.783 |
TYRO3 |
0.677 | -0.158 | 3 | 0.810 |
TNK1 |
0.677 | -0.059 | 3 | 0.788 |
TYK2 |
0.676 | -0.188 | 1 | 0.212 |
TNNI3K_TYR |
0.676 | -0.049 | 1 | 0.235 |
FGFR2 |
0.675 | -0.048 | 3 | 0.788 |
STLK3 |
0.674 | -0.195 | 1 | 0.182 |
YES1 |
0.674 | -0.104 | -1 | 0.740 |
ABL2 |
0.674 | -0.101 | -1 | 0.686 |
DDR1 |
0.674 | -0.139 | 4 | 0.748 |
KDR |
0.673 | -0.061 | 3 | 0.766 |
INSRR |
0.673 | -0.108 | 3 | 0.764 |
FGFR1 |
0.673 | -0.049 | 3 | 0.764 |
HCK |
0.672 | -0.081 | -1 | 0.762 |
ITK |
0.672 | -0.101 | -1 | 0.718 |
TEK |
0.671 | -0.024 | 3 | 0.750 |
ABL1 |
0.671 | -0.116 | -1 | 0.671 |
FGR |
0.670 | -0.158 | 1 | 0.196 |
MET |
0.670 | -0.063 | 3 | 0.794 |
KIT |
0.669 | -0.116 | 3 | 0.799 |
EPHA4 |
0.668 | -0.083 | 2 | 0.597 |
EPHB1 |
0.668 | -0.134 | 1 | 0.196 |
BMX |
0.666 | -0.085 | -1 | 0.649 |
EPHB2 |
0.666 | -0.119 | -1 | 0.721 |
PDGFRB |
0.666 | -0.201 | 3 | 0.813 |
FYN |
0.666 | -0.026 | -1 | 0.783 |
EPHB3 |
0.665 | -0.131 | -1 | 0.721 |
DDR2 |
0.665 | -0.044 | 3 | 0.748 |
AXL |
0.663 | -0.169 | 3 | 0.782 |
FER |
0.663 | -0.201 | 1 | 0.211 |
FLT3 |
0.663 | -0.183 | 3 | 0.811 |
FGFR3 |
0.663 | -0.067 | 3 | 0.763 |
SRMS |
0.662 | -0.176 | 1 | 0.191 |
MERTK |
0.662 | -0.154 | 3 | 0.771 |
PDGFRA |
0.662 | -0.196 | 3 | 0.804 |
FLT1 |
0.662 | -0.094 | -1 | 0.762 |
WEE1_TYR |
0.661 | -0.096 | -1 | 0.638 |
FRK |
0.661 | -0.110 | -1 | 0.758 |
PTK2 |
0.659 | 0.014 | -1 | 0.812 |
EPHA7 |
0.659 | -0.106 | 2 | 0.599 |
EPHA1 |
0.658 | -0.132 | 3 | 0.783 |
ERBB2 |
0.658 | -0.140 | 1 | 0.202 |
ALK |
0.657 | -0.162 | 3 | 0.732 |
TEC |
0.657 | -0.158 | -1 | 0.624 |
FLT4 |
0.655 | -0.150 | 3 | 0.740 |
YANK2 |
0.655 | -0.095 | 2 | 0.312 |
EGFR |
0.655 | -0.101 | 1 | 0.178 |
EPHA8 |
0.654 | -0.077 | -1 | 0.746 |
INSR |
0.654 | -0.161 | 3 | 0.746 |
BTK |
0.654 | -0.217 | -1 | 0.655 |
SRC |
0.654 | -0.095 | -1 | 0.738 |
PTK2B |
0.653 | -0.126 | -1 | 0.648 |
LYN |
0.653 | -0.114 | 3 | 0.712 |
SYK |
0.653 | -0.021 | -1 | 0.766 |
EPHA3 |
0.652 | -0.144 | 2 | 0.573 |
NTRK2 |
0.651 | -0.212 | 3 | 0.753 |
NTRK3 |
0.651 | -0.152 | -1 | 0.638 |
LTK |
0.651 | -0.193 | 3 | 0.736 |
ERBB4 |
0.650 | -0.051 | 1 | 0.179 |
CK1G3 |
0.650 | -0.078 | -3 | 0.319 |
NTRK1 |
0.649 | -0.229 | -1 | 0.685 |
MUSK |
0.649 | -0.125 | 1 | 0.161 |
PTK6 |
0.649 | -0.217 | -1 | 0.605 |
ZAP70 |
0.648 | -0.013 | -1 | 0.686 |
FGFR4 |
0.648 | -0.115 | -1 | 0.657 |
MATK |
0.647 | -0.127 | -1 | 0.614 |
EPHA5 |
0.647 | -0.142 | 2 | 0.570 |
CK1G2 |
0.645 | -0.043 | -3 | 0.405 |
EPHA2 |
0.644 | -0.093 | -1 | 0.712 |
CSK |
0.643 | -0.167 | 2 | 0.607 |
IGF1R |
0.639 | -0.146 | 3 | 0.676 |
FES |
0.625 | -0.152 | -1 | 0.604 |